                         SEQUENCE LISTING

<110>  DNAScript
 
<120>  Variants of Family A DNA Polymerase and uses thereof

<130>  B2560PC00

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  2590
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human Pol theta

<400>  1

Met Asn Leu Leu Arg Arg Ser Gly Lys Arg Arg Arg Ser Glu Ser Gly 
1               5                   10                  15      


Ser Asp Ser Phe Ser Gly Ser Gly Gly Asp Ser Ser Ala Ser Pro Gln 
            20                  25                  30          


Phe Leu Ser Gly Ser Val Leu Ser Pro Pro Pro Gly Leu Gly Arg Cys 
        35                  40                  45              


Leu Lys Ala Ala Ala Ala Gly Glu Cys Lys Pro Thr Val Pro Asp Tyr 
    50                  55                  60                  


Glu Arg Asp Lys Leu Leu Leu Ala Asn Trp Gly Leu Pro Lys Ala Val 
65                  70                  75                  80  


Leu Glu Lys Tyr His Ser Phe Gly Val Lys Lys Met Phe Glu Trp Gln 
                85                  90                  95      


Ala Glu Cys Leu Leu Leu Gly Gln Val Leu Glu Gly Lys Asn Leu Val 
            100                 105                 110         


Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu Leu 
        115                 120                 125             


Ile Leu Lys Arg Val Leu Glu Met Arg Lys Lys Ala Leu Phe Ile Leu 
    130                 135                 140                 


Pro Phe Val Ser Val Ala Lys Glu Lys Lys Tyr Tyr Leu Gln Ser Leu 
145                 150                 155                 160 


Phe Gln Glu Val Gly Ile Lys Val Asp Gly Tyr Met Gly Ser Thr Ser 
                165                 170                 175     


Pro Ser Arg His Phe Ser Ser Leu Asp Ile Ala Val Cys Thr Ile Glu 
            180                 185                 190         


Arg Ala Asn Gly Leu Ile Asn Arg Leu Ile Glu Glu Asn Lys Met Asp 
        195                 200                 205             


Leu Leu Gly Met Val Val Val Asp Glu Leu His Met Leu Gly Asp Ser 
    210                 215                 220                 


His Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Ile Cys Tyr Ile 
225                 230                 235                 240 


Thr Arg Lys Ser Ala Ser Cys Gln Ala Asp Leu Ala Ser Ser Leu Ser 
                245                 250                 255     


Asn Ala Val Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu Glu 
            260                 265                 270         


Leu Val Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe Arg 
        275                 280                 285             


Pro Val Pro Leu Leu Glu Ser Val Lys Val Gly Asn Ser Ile Tyr Asp 
    290                 295                 300                 


Ser Ser Met Lys Leu Val Arg Glu Phe Glu Pro Met Leu Gln Val Lys 
305                 310                 315                 320 


Gly Asp Glu Asp His Val Val Ser Leu Cys Tyr Glu Thr Ile Cys Asp 
                325                 330                 335     


Asn His Ser Val Leu Leu Phe Cys Pro Ser Lys Lys Trp Cys Glu Lys 
            340                 345                 350         


Leu Ala Asp Ile Ile Ala Arg Glu Phe Tyr Asn Leu His His Gln Ala 
        355                 360                 365             


Glu Gly Leu Val Lys Pro Ser Glu Cys Pro Pro Val Ile Leu Glu Gln 
    370                 375                 380                 


Lys Glu Leu Leu Glu Val Met Asp Gln Leu Arg Arg Leu Pro Ser Gly 
385                 390                 395                 400 


Leu Asp Ser Val Leu Gln Lys Thr Val Pro Trp Gly Val Ala Phe His 
                405                 410                 415     


His Ala Gly Leu Thr Phe Glu Glu Arg Asp Ile Ile Glu Gly Ala Phe 
            420                 425                 430         


Arg Gln Gly Leu Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser 
        435                 440                 445             


Gly Val Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Ile Phe 
    450                 455                 460                 


Gly Gly Arg Pro Leu Asp Ile Leu Thr Tyr Lys Gln Met Val Gly Arg 
465                 470                 475                 480 


Ala Gly Arg Lys Gly Val Asp Thr Val Gly Glu Ser Ile Leu Ile Cys 
                485                 490                 495     


Lys Asn Ser Glu Lys Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser Leu 
            500                 505                 510         


Lys Pro Val Arg Ser Cys Leu Gln Arg Arg Glu Gly Glu Glu Val Thr 
        515                 520                 525             


Gly Ser Met Ile Arg Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala 
    530                 535                 540                 


Ser Thr Ser Gln Asp Met His Thr Tyr Ala Ala Cys Thr Phe Leu Ala 
545                 550                 555                 560 


Ala Ser Met Lys Glu Gly Lys Gln Gly Ile Gln Arg Asn Gln Glu Ser 
                565                 570                 575     


Val Gln Leu Gly Ala Ile Glu Ala Cys Val Met Trp Leu Leu Glu Asn 
            580                 585                 590         


Glu Phe Ile Gln Ser Thr Glu Ala Ser Asp Gly Thr Glu Gly Lys Val 
        595                 600                 605             


Tyr His Pro Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser 
    610                 615                 620                 


Pro Ala Asp Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met Lys 
625                 630                 635                 640 


Gly Phe Val Leu Glu Asn Asp Leu His Ile Leu Tyr Leu Val Thr Pro 
                645                 650                 655     


Met Phe Glu Asp Trp Thr Thr Ile Asp Trp Tyr Arg Phe Phe Cys Leu 
            660                 665                 670         


Trp Glu Lys Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val Gly 
        675                 680                 685             


Val Glu Glu Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val Ala 
    690                 695                 700                 


Arg Thr Glu Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe 
705                 710                 715                 720 


Thr Ser Leu Val Leu Leu Asp Leu Ile Ser Glu Val Pro Leu Arg Glu 
                725                 730                 735     


Ile Asn Gln Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln 
            740                 745                 750         


Gln Ser Ala Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn Arg 
        755                 760                 765             


Leu Gly Trp His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg 
    770                 775                 780                 


Leu Thr Phe Gly Ile Gln Arg Glu Leu Cys Asp Leu Val Arg Val Ser 
785                 790                 795                 800 


Leu Leu Asn Ala Gln Arg Ala Arg Val Leu Tyr Ala Ser Gly Phe His 
                805                 810                 815     


Thr Val Ala Asp Leu Ala Arg Ala Asn Ile Val Glu Val Glu Val Ile 
            820                 825                 830         


Leu Lys Asn Ala Val Pro Phe Lys Ser Ala Arg Lys Ala Val Asp Glu 
        835                 840                 845             


Glu Glu Glu Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val 
    850                 855                 860                 


Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu Ala Ala Ala Leu Ile Val 
865                 870                 875                 880 


Glu Glu Ala Arg Met Ile Leu Gln Gln Asp Leu Val Glu Met Gly Val 
                885                 890                 895     


Gln Trp Asn Pro Cys Ala Leu Leu His Ser Ser Thr Cys Ser Leu Thr 
            900                 905                 910         


His Ser Glu Ser Glu Val Lys Glu His Thr Phe Ile Ser Gln Thr Lys 
        915                 920                 925             


Ser Ser Tyr Lys Lys Leu Thr Ser Lys Asn Lys Ser Asn Thr Ile Phe 
    930                 935                 940                 


Ser Asp Ser Tyr Ile Lys His Ser Pro Asn Ile Val Gln Asp Leu Asn 
945                 950                 955                 960 


Lys Ser Arg Glu His Thr Ser Ser Phe Asn Cys Asn Phe Gln Asn Gly 
                965                 970                 975     


Asn Gln Glu His Gln Thr Cys Ser Ile Phe Arg Ala Arg Lys Arg Ala 
            980                 985                 990         


Ser Leu Asp Ile Asn Lys Glu Lys  Pro Gly Ala Ser Gln  Asn Glu Gly 
        995                 1000                 1005             


Lys Thr  Ser Asp Lys Lys Val  Val Gln Thr Phe Ser  Gln Lys Thr 
    1010                 1015                 1020             


Lys Lys  Ala Pro Leu Asn Phe  Asn Ser Glu Lys Met  Ser Arg Ser 
    1025                 1030                 1035             


Phe Arg  Ser Trp Lys Arg Arg  Lys His Leu Lys Arg  Ser Arg Asp 
    1040                 1045                 1050             


Ser Ser  Pro Leu Lys Asp Ser  Gly Ala Cys Arg Ile  His Leu Gln 
    1055                 1060                 1065             


Gly Gln  Thr Leu Ser Asn Pro  Ser Leu Cys Glu Asp  Pro Phe Thr 
    1070                 1075                 1080             


Leu Asp  Glu Lys Lys Thr Glu  Phe Arg Asn Ser Gly  Pro Phe Ala 
    1085                 1090                 1095             


Lys Asn  Val Ser Leu Ser Gly  Lys Glu Lys Asp Asn  Lys Thr Ser 
    1100                 1105                 1110             


Phe Pro  Leu Gln Ile Lys Gln  Asn Cys Ser Trp Asn  Ile Thr Leu 
    1115                 1120                 1125             


Thr Asn  Asp Asn Phe Val Glu  His Ile Val Thr Gly  Ser Gln Ser 
    1130                 1135                 1140             


Lys Asn  Val Thr Cys Gln Ala  Thr Ser Val Val Ser  Glu Lys Gly 
    1145                 1150                 1155             


Arg Gly  Val Ala Val Glu Ala  Glu Lys Ile Asn Glu  Val Leu Ile 
    1160                 1165                 1170             


Gln Asn  Gly Ser Lys Asn Gln  Asn Val Tyr Met Lys  His His Asp 
    1175                 1180                 1185             


Ile His  Pro Ile Asn Gln Tyr  Leu Arg Lys Gln Ser  His Glu Gln 
    1190                 1195                 1200             


Thr Ser  Thr Ile Thr Lys Gln  Lys Asn Ile Ile Glu  Arg Gln Met 
    1205                 1210                 1215             


Pro Cys  Glu Ala Val Ser Ser  Tyr Ile Asn Arg Asp  Ser Asn Val 
    1220                 1225                 1230             


Thr Ile  Asn Cys Glu Arg Ile  Lys Leu Asn Thr Glu  Glu Asn Lys 
    1235                 1240                 1245             


Pro Ser  His Phe Gln Ala Leu  Gly Asp Asp Ile Ser  Arg Thr Val 
    1250                 1255                 1260             


Ile Pro  Ser Glu Val Leu Pro  Ser Ala Gly Ala Phe  Ser Lys Ser 
    1265                 1270                 1275             


Glu Gly  Gln His Glu Asn Phe  Leu Asn Ile Ser Arg  Leu Gln Glu 
    1280                 1285                 1290             


Lys Thr  Gly Thr Tyr Thr Thr  Asn Lys Thr Lys Asn  Asn His Val 
    1295                 1300                 1305             


Ser Asp  Leu Gly Leu Val Leu  Cys Asp Phe Glu Asp  Ser Phe Tyr 
    1310                 1315                 1320             


Leu Asp  Thr Gln Ser Glu Lys  Ile Ile Gln Gln Met  Ala Thr Glu 
    1325                 1330                 1335             


Asn Ala  Lys Leu Gly Ala Lys  Asp Thr Asn Leu Ala  Ala Gly Ile 
    1340                 1345                 1350             


Met Gln  Lys Ser Leu Val Gln  Gln Asn Ser Met Asn  Ser Phe Gln 
    1355                 1360                 1365             


Lys Glu  Cys His Ile Pro Phe  Pro Ala Glu Gln His  Pro Leu Gly 
    1370                 1375                 1380             


Ala Thr  Lys Ile Asp His Leu  Asp Leu Lys Thr Val  Gly Thr Met 
    1385                 1390                 1395             


Lys Gln  Ser Ser Asp Ser His  Gly Val Asp Ile Leu  Thr Pro Glu 
    1400                 1405                 1410             


Ser Pro  Ile Phe His Ser Pro  Ile Leu Leu Glu Glu  Asn Gly Leu 
    1415                 1420                 1425             


Phe Leu  Lys Lys Asn Glu Val  Ser Val Thr Asp Ser  Gln Leu Asn 
    1430                 1435                 1440             


Ser Phe  Leu Gln Gly Tyr Gln  Thr Gln Glu Thr Val  Lys Pro Val 
    1445                 1450                 1455             


Ile Leu  Leu Ile Pro Gln Lys  Arg Thr Pro Thr Gly  Val Glu Gly 
    1460                 1465                 1470             


Glu Cys  Leu Pro Val Pro Glu  Thr Ser Leu Asn Met  Ser Asp Ser 
    1475                 1480                 1485             


Leu Leu  Phe Asp Ser Phe Ser  Asp Asp Tyr Leu Val  Lys Glu Gln 
    1490                 1495                 1500             


Leu Pro  Asp Met Gln Met Lys  Glu Pro Leu Pro Ser  Glu Val Thr 
    1505                 1510                 1515             


Ser Asn  His Phe Ser Asp Ser  Leu Cys Leu Gln Glu  Asp Leu Ile 
    1520                 1525                 1530             


Lys Lys  Ser Asn Val Asn Glu  Asn Gln Asp Thr His  Gln Gln Leu 
    1535                 1540                 1545             


Thr Cys  Ser Asn Asp Glu Ser  Ile Ile Phe Ser Glu  Met Asp Ser 
    1550                 1555                 1560             


Val Gln  Met Val Glu Ala Leu  Asp Asn Val Asp Ile  Phe Pro Val 
    1565                 1570                 1575             


Gln Glu  Lys Asn His Thr Val  Val Ser Pro Arg Ala  Leu Glu Leu 
    1580                 1585                 1590             


Ser Asp  Pro Val Leu Asp Glu  His His Gln Gly Asp  Gln Asp Gly 
    1595                 1600                 1605             


Gly Asp  Gln Asp Glu Arg Ala  Glu Lys Ser Lys Leu  Thr Gly Thr 
    1610                 1615                 1620             


Arg Gln  Asn His Ser Phe Ile  Trp Ser Gly Ala Ser  Phe Asp Leu 
    1625                 1630                 1635             


Ser Pro  Gly Leu Gln Arg Ile  Leu Asp Lys Val Ser  Ser Pro Leu 
    1640                 1645                 1650             


Glu Asn  Glu Lys Leu Lys Ser  Met Thr Ile Asn Phe  Ser Ser Leu 
    1655                 1660                 1665             


Asn Arg  Lys Asn Thr Glu Leu  Asn Glu Glu Gln Glu  Val Ile Ser 
    1670                 1675                 1680             


Asn Leu  Glu Thr Lys Gln Val  Gln Gly Ile Ser Phe  Ser Ser Asn 
    1685                 1690                 1695             


Asn Glu  Val Lys Ser Lys Ile  Glu Met Leu Glu Asn  Asn Ala Asn 
    1700                 1705                 1710             


His Asp  Glu Thr Ser Ser Leu  Leu Pro Arg Lys Glu  Ser Asn Ile 
    1715                 1720                 1725             


Val Asp  Asp Asn Gly Leu Ile  Pro Pro Thr Pro Ile  Pro Thr Ser 
    1730                 1735                 1740             


Ala Ser  Lys Leu Thr Phe Pro  Gly Ile Leu Glu Thr  Pro Val Asn 
    1745                 1750                 1755             


Pro Trp  Lys Thr Asn Asn Val  Leu Gln Pro Gly Glu  Ser Tyr Leu 
    1760                 1765                 1770             


Phe Gly  Ser Pro Ser Asp Ile  Lys Asn His Asp Leu  Ser Pro Gly 
    1775                 1780                 1785             


Ser Arg  Asn Gly Phe Lys Asp  Asn Ser Pro Ile Ser  Asp Thr Ser 
    1790                 1795                 1800             


Phe Ser  Leu Gln Leu Ser Gln  Asp Gly Leu Gln Leu  Thr Pro Ala 
    1805                 1810                 1815             


Ser Ser  Ser Ser Glu Ser Leu  Ser Ile Ile Asp Val  Ala Ser Asp 
    1820                 1825                 1830             


Gln Asn  Leu Phe Gln Thr Phe  Ile Lys Glu Trp Arg  Cys Lys Lys 
    1835                 1840                 1845             


Arg Phe  Ser Ile Ser Leu Ala  Cys Glu Lys Ile Arg  Ser Leu Thr 
    1850                 1855                 1860             


Ser Ser  Lys Thr Ala Thr Ile  Gly Ser Arg Phe Lys  Gln Ala Ser 
    1865                 1870                 1875             


Ser Pro  Gln Glu Ile Pro Ile  Arg Asp Asp Gly Phe  Pro Ile Lys 
    1880                 1885                 1890             


Gly Cys  Asp Asp Thr Leu Val  Val Gly Leu Ala Val  Cys Trp Gly 
    1895                 1900                 1905             


Gly Arg  Asp Ala Tyr Tyr Phe  Ser Leu Gln Lys Glu  Gln Lys His 
    1910                 1915                 1920             


Ser Glu  Ile Ser Ala Ser Leu  Val Pro Pro Ser Leu  Asp Pro Ser 
    1925                 1930                 1935             


Leu Thr  Leu Lys Asp Arg Met  Trp Tyr Leu Gln Ser  Cys Leu Arg 
    1940                 1945                 1950             


Lys Glu  Ser Asp Lys Glu Cys  Ser Val Val Ile Tyr  Asp Phe Ile 
    1955                 1960                 1965             


Gln Ser  Tyr Lys Ile Leu Leu  Leu Ser Cys Gly Ile  Ser Leu Glu 
    1970                 1975                 1980             


Gln Ser  Tyr Glu Asp Pro Lys  Val Ala Cys Trp Leu  Leu Asp Pro 
    1985                 1990                 1995             


Asp Ser  Gln Glu Pro Thr Leu  His Ser Ile Val Thr  Ser Phe Leu 
    2000                 2005                 2010             


Pro His  Glu Leu Pro Leu Leu  Glu Gly Met Glu Thr  Ser Gln Gly 
    2015                 2020                 2025             


Ile Gln  Ser Leu Gly Leu Asn  Ala Gly Ser Glu His  Ser Gly Arg 
    2030                 2035                 2040             


Tyr Arg  Ala Ser Val Glu Ser  Ile Leu Ile Phe Asn  Ser Met Asn 
    2045                 2050                 2055             


Gln Leu  Asn Ser Leu Leu Gln  Lys Glu Asn Leu Gln  Asp Val Phe 
    2060                 2065                 2070             


Arg Lys  Val Glu Met Pro Ser  Gln Tyr Cys Leu Ala  Leu Leu Glu 
    2075                 2080                 2085             


Leu Asn  Gly Ile Gly Phe Ser  Thr Ala Glu Cys Glu  Ser Gln Lys 
    2090                 2095                 2100             


His Ile  Met Gln Ala Lys Leu  Asp Ala Ile Glu Thr  Gln Ala Tyr 
    2105                 2110                 2115             


Gln Leu  Ala Gly His Ser Phe  Ser Phe Thr Ser Ser  Asp Asp Ile 
    2120                 2125                 2130             


Ala Glu  Val Leu Phe Leu Glu  Leu Lys Leu Pro Pro  Asn Arg Glu 
    2135                 2140                 2145             


Met Lys  Asn Gln Gly Ser Lys  Lys Thr Leu Gly Ser  Thr Arg Arg 
    2150                 2155                 2160             


Gly Ile  Asp Asn Gly Arg Lys  Leu Arg Leu Gly Arg  Gln Phe Ser 
    2165                 2170                 2175             


Thr Ser  Lys Asp Val Leu Asn  Lys Leu Lys Ala Leu  His Pro Leu 
    2180                 2185                 2190             


Pro Gly  Leu Ile Leu Glu Trp  Arg Arg Ile Thr Asn  Ala Ile Thr 
    2195                 2200                 2205             


Lys Val  Val Phe Pro Leu Gln  Arg Glu Lys Cys Leu  Asn Pro Phe 
    2210                 2215                 2220             


Leu Gly  Met Glu Arg Ile Tyr  Pro Val Ser Gln Ser  His Thr Ala 
    2225                 2230                 2235             


Thr Gly  Arg Ile Thr Phe Thr  Glu Pro Asn Ile Gln  Asn Val Pro 
    2240                 2245                 2250             


Arg Asp  Phe Glu Ile Lys Met  Pro Thr Leu Val Gly  Glu Ser Pro 
    2255                 2260                 2265             


Pro Ser  Gln Ala Val Gly Lys  Gly Leu Leu Pro Met  Gly Arg Gly 
    2270                 2275                 2280             


Lys Tyr  Lys Lys Gly Phe Ser  Val Asn Pro Arg Cys  Gln Ala Gln 
    2285                 2290                 2295             


Met Glu  Glu Arg Ala Ala Asp  Arg Gly Met Pro Phe  Ser Ile Ser 
    2300                 2305                 2310             


Met Arg  His Ala Phe Val Pro  Phe Pro Gly Gly Ser  Ile Leu Ala 
    2315                 2320                 2325             


Ala Asp  Tyr Ser Gln Leu Glu  Leu Arg Ile Leu Ala  His Leu Ser 
    2330                 2335                 2340             


His Asp  Arg Arg Leu Ile Gln  Val Leu Asn Thr Gly  Ala Asp Val 
    2345                 2350                 2355             


Phe Arg  Ser Ile Ala Ala Glu  Trp Lys Met Ile Glu  Pro Glu Ser 
    2360                 2365                 2370             


Val Gly  Asp Asp Leu Arg Gln  Gln Ala Lys Gln Ile  Cys Tyr Gly 
    2375                 2380                 2385             


Ile Ile  Tyr Gly Met Gly Ala  Lys Ser Leu Gly Glu  Gln Met Gly 
    2390                 2395                 2400             


Ile Lys  Glu Asn Asp Ala Ala  Cys Tyr Ile Asp Ser  Phe Lys Ser 
    2405                 2410                 2415             


Arg Tyr  Thr Gly Ile Asn Gln  Phe Met Thr Glu Thr  Val Lys Asn 
    2420                 2425                 2430             


Cys Lys  Arg Asp Gly Phe Val  Gln Thr Ile Leu Gly  Arg Arg Arg 
    2435                 2440                 2445             


Tyr Leu  Pro Gly Ile Lys Asp  Asn Asn Pro Tyr Arg  Lys Ala His 
    2450                 2455                 2460             


Ala Glu  Arg Gln Ala Ile Asn  Thr Ile Val Gln Gly  Ser Ala Ala 
    2465                 2470                 2475             


Asp Ile  Val Lys Ile Ala Thr  Val Asn Ile Gln Lys  Gln Leu Glu 
    2480                 2485                 2490             


Thr Phe  His Ser Thr Phe Lys  Ser His Gly His Arg  Glu Gly Met 
    2495                 2500                 2505             


Leu Gln  Ser Asp Gln Thr Gly  Leu Ser Arg Lys Arg  Lys Leu Gln 
    2510                 2515                 2520             


Gly Met  Phe Cys Pro Ile Arg  Gly Gly Phe Phe Ile  Leu Gln Leu 
    2525                 2530                 2535             


His Asp  Glu Leu Leu Tyr Glu  Val Ala Glu Glu Asp  Val Val Gln 
    2540                 2545                 2550             


Val Ala  Gln Ile Val Lys Asn  Glu Met Glu Ser Ala  Val Lys Leu 
    2555                 2560                 2565             


Ser Val  Lys Leu Lys Val Lys  Val Lys Ile Gly Ala  Ser Trp Gly 
    2570                 2575                 2580             


Glu Leu  Lys Asp Phe Asp Val  
    2585                 2590 


<210>  2
<211>  799
<212>  PRT
<213>  artificial sequence

<220>
<223>  pol Theta polymerase domain

<400>  2

Gly Phe Lys Asp Asn Ser Pro Ile Ser Asp Thr Ser Phe Ser Leu Gln 
1               5                   10                  15      


Leu Ser Gln Asp Gly Leu Gln Leu Thr Pro Ala Ser Ser Ser Ser Glu 
            20                  25                  30          


Ser Leu Ser Ile Ile Asp Val Ala Ser Asp Gln Asn Leu Phe Gln Thr 
        35                  40                  45              


Phe Ile Lys Glu Trp Arg Cys Lys Lys Arg Phe Ser Ile Ser Leu Ala 
    50                  55                  60                  


Cys Glu Lys Ile Arg Ser Leu Thr Ser Ser Lys Thr Ala Thr Ile Gly 
65                  70                  75                  80  


Ser Arg Phe Lys Gln Ala Ser Ser Pro Gln Glu Ile Pro Ile Arg Asp 
                85                  90                  95      


Asp Gly Phe Pro Ile Lys Gly Cys Asp Asp Thr Leu Val Val Gly Leu 
            100                 105                 110         


Ala Val Cys Trp Gly Gly Arg Asp Ala Tyr Tyr Phe Ser Leu Gln Lys 
        115                 120                 125             


Glu Gln Lys His Ser Glu Ile Ser Ala Ser Leu Val Pro Pro Ser Leu 
    130                 135                 140                 


Asp Pro Ser Leu Thr Leu Lys Asp Arg Met Trp Tyr Leu Gln Ser Cys 
145                 150                 155                 160 


Leu Arg Lys Glu Ser Asp Lys Glu Cys Ser Val Val Ile Tyr Asp Phe 
                165                 170                 175     


Ile Gln Ser Tyr Lys Ile Leu Leu Leu Ser Cys Gly Ile Ser Leu Glu 
            180                 185                 190         


Gln Ser Tyr Glu Asp Pro Lys Val Ala Cys Trp Leu Leu Asp Pro Asp 
        195                 200                 205             


Ser Gln Glu Pro Thr Leu His Ser Ile Val Thr Ser Phe Leu Pro His 
    210                 215                 220                 


Glu Leu Pro Leu Leu Glu Gly Met Glu Thr Ser Gln Gly Ile Gln Ser 
225                 230                 235                 240 


Leu Gly Leu Asn Ala Gly Ser Glu His Ser Gly Arg Tyr Arg Ala Ser 
                245                 250                 255     


Val Glu Ser Ile Leu Ile Phe Asn Ser Met Asn Gln Leu Asn Ser Leu 
            260                 265                 270         


Leu Gln Lys Glu Asn Leu Gln Asp Val Phe Arg Lys Val Glu Met Pro 
        275                 280                 285             


Ser Gln Tyr Cys Leu Ala Leu Leu Glu Leu Asn Gly Ile Gly Phe Ser 
    290                 295                 300                 


Thr Ala Glu Cys Glu Ser Gln Lys His Ile Met Gln Ala Lys Leu Asp 
305                 310                 315                 320 


Ala Ile Glu Thr Gln Ala Tyr Gln Leu Ala Gly His Ser Phe Ser Phe 
                325                 330                 335     


Thr Ser Ser Asp Asp Ile Ala Glu Val Leu Phe Leu Glu Leu Lys Leu 
            340                 345                 350         


Pro Pro Asn Arg Glu Met Lys Asn Gln Gly Ser Lys Lys Thr Leu Gly 
        355                 360                 365             


Ser Thr Arg Arg Gly Ile Asp Asn Gly Arg Lys Leu Arg Leu Gly Arg 
    370                 375                 380                 


Gln Phe Ser Thr Ser Lys Asp Val Leu Asn Lys Leu Lys Ala Leu His 
385                 390                 395                 400 


Pro Leu Pro Gly Leu Ile Leu Glu Trp Arg Arg Ile Thr Asn Ala Ile 
                405                 410                 415     


Thr Lys Val Val Phe Pro Leu Gln Arg Glu Lys Cys Leu Asn Pro Phe 
            420                 425                 430         


Leu Gly Met Glu Arg Ile Tyr Pro Val Ser Gln Ser His Thr Ala Thr 
        435                 440                 445             


Gly Arg Ile Thr Phe Thr Glu Pro Asn Ile Gln Asn Val Pro Arg Asp 
    450                 455                 460                 


Phe Glu Ile Lys Met Pro Thr Leu Val Gly Glu Ser Pro Pro Ser Gln 
465                 470                 475                 480 


Ala Val Gly Lys Gly Leu Leu Pro Met Gly Arg Gly Lys Tyr Lys Lys 
                485                 490                 495     


Gly Phe Ser Val Asn Pro Arg Cys Gln Ala Gln Met Glu Glu Arg Ala 
            500                 505                 510         


Ala Asp Arg Gly Met Pro Phe Ser Ile Ser Met Arg His Ala Phe Val 
        515                 520                 525             


Pro Phe Pro Gly Gly Ser Ile Leu Ala Ala Asp Tyr Ser Gln Leu Glu 
    530                 535                 540                 


Leu Arg Ile Leu Ala His Leu Ser His Asp Arg Arg Leu Ile Gln Val 
545                 550                 555                 560 


Leu Asn Thr Gly Ala Asp Val Phe Arg Ser Ile Ala Ala Glu Trp Lys 
                565                 570                 575     


Met Ile Glu Pro Glu Ser Val Gly Asp Asp Leu Arg Gln Gln Ala Lys 
            580                 585                 590         


Gln Ile Cys Tyr Gly Ile Ile Tyr Gly Met Gly Ala Lys Ser Leu Gly 
        595                 600                 605             


Glu Gln Met Gly Ile Lys Glu Asn Asp Ala Ala Cys Tyr Ile Asp Ser 
    610                 615                 620                 


Phe Lys Ser Arg Tyr Thr Gly Ile Asn Gln Phe Met Thr Glu Thr Val 
625                 630                 635                 640 


Lys Asn Cys Lys Arg Asp Gly Phe Val Gln Thr Ile Leu Gly Arg Arg 
                645                 650                 655     


Arg Tyr Leu Pro Gly Ile Lys Asp Asn Asn Pro Tyr Arg Lys Ala His 
            660                 665                 670         


Ala Glu Arg Gln Ala Ile Asn Thr Ile Val Gln Gly Ser Ala Ala Asp 
        675                 680                 685             


Ile Val Lys Ile Ala Thr Val Asn Ile Gln Lys Gln Leu Glu Thr Phe 
    690                 695                 700                 


His Ser Thr Phe Lys Ser His Gly His Arg Glu Gly Met Leu Gln Ser 
705                 710                 715                 720 


Asp Gln Thr Gly Leu Ser Arg Lys Arg Lys Leu Gln Gly Met Phe Cys 
                725                 730                 735     


Pro Ile Arg Gly Gly Phe Phe Ile Leu Gln Leu His Asp Glu Leu Leu 
            740                 745                 750         


Tyr Glu Val Ala Glu Glu Asp Val Val Gln Val Ala Gln Ile Val Lys 
        755                 760                 765             


Asn Glu Met Glu Ser Ala Val Lys Leu Ser Val Lys Leu Lys Val Lys 
    770                 775                 780                 


Val Lys Ile Gly Ala Ser Trp Gly Glu Leu Lys Asp Phe Asp Val 
785                 790                 795                 


<210>  3
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  fragment of Pol theta

<400>  3

Asp Tyr Ser Gln Leu Glu Leu Arg Ile Leu 
1               5                   10  


<210>  4
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  fragment of Pol Theta

<400>  4

Pro Gly Gly Ser Ile Leu Ala Ala 
1               5               


<210>  5
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  fragment of Pol Theta

<400>  5

Asp Asp Leu Arg Gln Gln Ala Lys Gln Ile Cys Tyr Gly Ile Ile Tyr 
1               5                   10                  15      


<210>  6
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  fragment of Pol Theta

<400>  6

Glu Trp Arg Arg Ile Thr 
1               5       


<210>  7
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  7
taatacgact cactataggg                                                   20


<210>  8
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  8
gctagttatt gctcagcgg                                                    19


<210>  9
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  9
aaaaaaaaaa aaaagggg                                                     18


<210>  10
<211>  2590
<212>  PRT
<213>  human

<400>  10

Met Asn Leu Leu Arg Arg Ser Gly Lys Arg Arg Arg Ser Glu Ser Gly 
1               5                   10                  15      


Ser Asp Ser Phe Ser Gly Ser Gly Gly Asp Ser Ser Ala Ser Pro Gln 
            20                  25                  30          


Phe Leu Ser Gly Ser Val Leu Ser Pro Pro Pro Gly Leu Gly Arg Cys 
        35                  40                  45              


Leu Lys Ala Ala Ala Ala Gly Glu Cys Lys Pro Thr Val Pro Asp Tyr 
    50                  55                  60                  


Glu Arg Asp Lys Leu Leu Leu Ala Asn Trp Gly Leu Pro Lys Ala Val 
65                  70                  75                  80  


Leu Glu Lys Tyr His Ser Phe Gly Val Lys Lys Met Phe Glu Trp Gln 
                85                  90                  95      


Ala Glu Cys Leu Leu Leu Gly Gln Val Leu Glu Gly Lys Asn Leu Val 
            100                 105                 110         


Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu Leu 
        115                 120                 125             


Ile Leu Lys Arg Val Leu Glu Met Arg Lys Lys Ala Leu Phe Ile Leu 
    130                 135                 140                 


Pro Phe Val Ser Val Ala Lys Glu Lys Lys Tyr Tyr Leu Gln Ser Leu 
145                 150                 155                 160 


Phe Gln Glu Val Gly Ile Lys Val Asp Gly Tyr Met Gly Ser Thr Ser 
                165                 170                 175     


Pro Ser Arg His Phe Ser Ser Leu Asp Ile Ala Val Cys Thr Ile Glu 
            180                 185                 190         


Arg Ala Asn Gly Leu Ile Asn Arg Leu Ile Glu Glu Asn Lys Met Asp 
        195                 200                 205             


Leu Leu Gly Met Val Val Val Asp Glu Leu His Met Leu Gly Asp Ser 
    210                 215                 220                 


His Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Ile Cys Tyr Ile 
225                 230                 235                 240 


Thr Arg Lys Ser Ala Ser Cys Gln Ala Asp Leu Ala Ser Ser Leu Ser 
                245                 250                 255     


Asn Ala Val Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu Glu 
            260                 265                 270         


Leu Val Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe Arg 
        275                 280                 285             


Pro Val Pro Leu Leu Glu Ser Val Lys Val Gly Asn Ser Ile Tyr Asp 
    290                 295                 300                 


Ser Ser Met Lys Leu Val Arg Glu Phe Glu Pro Met Leu Gln Val Lys 
305                 310                 315                 320 


Gly Asp Glu Asp His Val Val Ser Leu Cys Tyr Glu Thr Ile Cys Asp 
                325                 330                 335     


Asn His Ser Val Leu Leu Phe Cys Pro Ser Lys Lys Trp Cys Glu Lys 
            340                 345                 350         


Leu Ala Asp Ile Ile Ala Arg Glu Phe Tyr Asn Leu His His Gln Ala 
        355                 360                 365             


Glu Gly Leu Val Lys Pro Ser Glu Cys Pro Pro Val Ile Leu Glu Gln 
    370                 375                 380                 


Lys Glu Leu Leu Glu Val Met Asp Gln Leu Arg Arg Leu Pro Ser Gly 
385                 390                 395                 400 


Leu Asp Ser Val Leu Gln Lys Thr Val Pro Trp Gly Val Ala Phe His 
                405                 410                 415     


His Ala Gly Leu Thr Phe Glu Glu Arg Asp Ile Ile Glu Gly Ala Phe 
            420                 425                 430         


Arg Gln Gly Leu Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser 
        435                 440                 445             


Gly Val Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Ile Phe 
    450                 455                 460                 


Gly Gly Arg Pro Leu Asp Ile Leu Thr Tyr Lys Gln Met Val Gly Arg 
465                 470                 475                 480 


Ala Gly Arg Lys Gly Val Asp Thr Val Gly Glu Ser Ile Leu Ile Cys 
                485                 490                 495     


Lys Asn Ser Glu Lys Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser Leu 
            500                 505                 510         


Lys Pro Val Arg Ser Cys Leu Gln Arg Arg Glu Gly Glu Glu Val Thr 
        515                 520                 525             


Gly Ser Met Ile Arg Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala 
    530                 535                 540                 


Ser Thr Ser Gln Asp Met His Thr Tyr Ala Ala Cys Thr Phe Leu Ala 
545                 550                 555                 560 


Ala Ser Met Lys Glu Gly Lys Gln Gly Ile Gln Arg Asn Gln Glu Ser 
                565                 570                 575     


Val Gln Leu Gly Ala Ile Glu Ala Cys Val Met Trp Leu Leu Glu Asn 
            580                 585                 590         


Glu Phe Ile Gln Ser Thr Glu Ala Ser Asp Gly Thr Glu Gly Lys Val 
        595                 600                 605             


Tyr His Pro Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser 
    610                 615                 620                 


Pro Ala Asp Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met Lys 
625                 630                 635                 640 


Gly Phe Val Leu Glu Asn Asp Leu His Ile Leu Tyr Leu Val Thr Pro 
                645                 650                 655     


Met Phe Glu Asp Trp Thr Thr Ile Asp Trp Tyr Arg Phe Phe Cys Leu 
            660                 665                 670         


Trp Glu Lys Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val Gly 
        675                 680                 685             


Val Glu Glu Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val Ala 
    690                 695                 700                 


Arg Thr Glu Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe 
705                 710                 715                 720 


Thr Ser Leu Val Leu Leu Asp Leu Ile Ser Glu Val Pro Leu Arg Glu 
                725                 730                 735     


Ile Asn Gln Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln 
            740                 745                 750         


Gln Ser Ala Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn Arg 
        755                 760                 765             


Leu Gly Trp His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg 
    770                 775                 780                 


Leu Thr Phe Gly Ile Gln Arg Glu Leu Cys Asp Leu Val Arg Val Ser 
785                 790                 795                 800 


Leu Leu Asn Ala Gln Arg Ala Arg Val Leu Tyr Ala Ser Gly Phe His 
                805                 810                 815     


Thr Val Ala Asp Leu Ala Arg Ala Asn Ile Val Glu Val Glu Val Ile 
            820                 825                 830         


Leu Lys Asn Ala Val Pro Phe Lys Ser Ala Arg Lys Ala Val Asp Glu 
        835                 840                 845             


Glu Glu Glu Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val 
    850                 855                 860                 


Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu Ala Ala Ala Leu Ile Val 
865                 870                 875                 880 


Glu Glu Ala Arg Met Ile Leu Gln Gln Asp Leu Val Glu Met Gly Val 
                885                 890                 895     


Gln Trp Asn Pro Cys Ala Leu Leu His Ser Ser Thr Cys Ser Leu Thr 
            900                 905                 910         


His Ser Glu Ser Glu Val Lys Glu His Thr Phe Ile Ser Gln Thr Lys 
        915                 920                 925             


Ser Ser Tyr Lys Lys Leu Thr Ser Lys Asn Lys Ser Asn Thr Ile Phe 
    930                 935                 940                 


Ser Asp Ser Tyr Ile Lys His Ser Pro Asn Ile Val Gln Asp Leu Asn 
945                 950                 955                 960 


Lys Ser Arg Glu His Thr Ser Ser Phe Asn Cys Asn Phe Gln Asn Gly 
                965                 970                 975     


Asn Gln Glu His Gln Thr Cys Ser Ile Phe Arg Ala Arg Lys Arg Ala 
            980                 985                 990         


Ser Leu Asp Ile Asn Lys Glu Lys  Pro Gly Ala Ser Gln  Asn Glu Gly 
        995                 1000                 1005             


Lys Thr  Ser Asp Lys Lys Val  Val Gln Thr Phe Ser  Gln Lys Thr 
    1010                 1015                 1020             


Lys Lys  Ala Pro Leu Asn Phe  Asn Ser Glu Lys Met  Ser Arg Ser 
    1025                 1030                 1035             


Phe Arg  Ser Trp Lys Arg Arg  Lys His Leu Lys Arg  Ser Arg Asp 
    1040                 1045                 1050             


Ser Ser  Pro Leu Lys Asp Ser  Gly Ala Cys Arg Ile  His Leu Gln 
    1055                 1060                 1065             


Gly Gln  Thr Leu Ser Asn Pro  Ser Leu Cys Glu Asp  Pro Phe Thr 
    1070                 1075                 1080             


Leu Asp  Glu Lys Lys Thr Glu  Phe Arg Asn Ser Gly  Pro Phe Ala 
    1085                 1090                 1095             


Lys Asn  Val Ser Leu Ser Gly  Lys Glu Lys Asp Asn  Lys Thr Ser 
    1100                 1105                 1110             


Phe Pro  Leu Gln Ile Lys Gln  Asn Cys Ser Trp Asn  Ile Thr Leu 
    1115                 1120                 1125             


Thr Asn  Asp Asn Phe Val Glu  His Ile Val Thr Gly  Ser Gln Ser 
    1130                 1135                 1140             


Lys Asn  Val Thr Cys Gln Ala  Thr Ser Val Val Ser  Glu Lys Gly 
    1145                 1150                 1155             


Arg Gly  Val Ala Val Glu Ala  Glu Lys Ile Asn Glu  Val Leu Ile 
    1160                 1165                 1170             


Gln Asn  Gly Ser Lys Asn Gln  Asn Val Tyr Met Lys  His His Asp 
    1175                 1180                 1185             


Ile His  Pro Ile Asn Gln Tyr  Leu Arg Lys Gln Ser  His Glu Gln 
    1190                 1195                 1200             


Thr Ser  Thr Ile Thr Lys Gln  Lys Asn Ile Ile Glu  Arg Gln Met 
    1205                 1210                 1215             


Pro Cys  Glu Ala Val Ser Ser  Tyr Ile Asn Arg Asp  Ser Asn Val 
    1220                 1225                 1230             


Thr Ile  Asn Cys Glu Arg Ile  Lys Leu Asn Thr Glu  Glu Asn Lys 
    1235                 1240                 1245             


Pro Ser  His Phe Gln Ala Leu  Gly Asp Asp Ile Ser  Arg Thr Val 
    1250                 1255                 1260             


Ile Pro  Ser Glu Val Leu Pro  Ser Ala Gly Ala Phe  Ser Lys Ser 
    1265                 1270                 1275             


Glu Gly  Gln His Glu Asn Phe  Leu Asn Ile Ser Arg  Leu Gln Glu 
    1280                 1285                 1290             


Lys Thr  Gly Thr Tyr Thr Thr  Asn Lys Thr Lys Asn  Asn His Val 
    1295                 1300                 1305             


Ser Asp  Leu Gly Leu Val Leu  Cys Asp Phe Glu Asp  Ser Phe Tyr 
    1310                 1315                 1320             


Leu Asp  Thr Gln Ser Glu Lys  Ile Ile Gln Gln Met  Ala Thr Glu 
    1325                 1330                 1335             


Asn Ala  Lys Leu Gly Ala Lys  Asp Thr Asn Leu Ala  Ala Gly Ile 
    1340                 1345                 1350             


Met Gln  Lys Ser Leu Val Gln  Gln Asn Ser Met Asn  Ser Phe Gln 
    1355                 1360                 1365             


Lys Glu  Cys His Ile Pro Phe  Pro Ala Glu Gln His  Pro Leu Gly 
    1370                 1375                 1380             


Ala Thr  Lys Ile Asp His Leu  Asp Leu Lys Thr Val  Gly Thr Met 
    1385                 1390                 1395             


Lys Gln  Ser Ser Asp Ser His  Gly Val Asp Ile Leu  Thr Pro Glu 
    1400                 1405                 1410             


Ser Pro  Ile Phe His Ser Pro  Ile Leu Leu Glu Glu  Asn Gly Leu 
    1415                 1420                 1425             


Phe Leu  Lys Lys Asn Glu Val  Ser Val Thr Asp Ser  Gln Leu Asn 
    1430                 1435                 1440             


Ser Phe  Leu Gln Gly Tyr Gln  Thr Gln Glu Thr Val  Lys Pro Val 
    1445                 1450                 1455             


Ile Leu  Leu Ile Pro Gln Lys  Arg Thr Pro Thr Gly  Val Glu Gly 
    1460                 1465                 1470             


Glu Cys  Leu Pro Val Pro Glu  Thr Ser Leu Asn Met  Ser Asp Ser 
    1475                 1480                 1485             


Leu Leu  Phe Asp Ser Phe Ser  Asp Asp Tyr Leu Val  Lys Glu Gln 
    1490                 1495                 1500             


Leu Pro  Asp Met Gln Met Lys  Glu Pro Leu Pro Ser  Glu Val Thr 
    1505                 1510                 1515             


Ser Asn  His Phe Ser Asp Ser  Leu Cys Leu Gln Glu  Asp Leu Ile 
    1520                 1525                 1530             


Lys Lys  Ser Asn Val Asn Glu  Asn Gln Asp Thr His  Gln Gln Leu 
    1535                 1540                 1545             


Thr Cys  Ser Asn Asp Glu Ser  Ile Ile Phe Ser Glu  Met Asp Ser 
    1550                 1555                 1560             


Val Gln  Met Val Glu Ala Leu  Asp Asn Val Asp Ile  Phe Pro Val 
    1565                 1570                 1575             


Gln Glu  Lys Asn His Thr Val  Val Ser Pro Arg Ala  Leu Glu Leu 
    1580                 1585                 1590             


Ser Asp  Pro Val Leu Asp Glu  His His Gln Gly Asp  Gln Asp Gly 
    1595                 1600                 1605             


Gly Asp  Gln Asp Glu Arg Ala  Glu Lys Ser Lys Leu  Thr Gly Thr 
    1610                 1615                 1620             


Arg Gln  Asn His Ser Phe Ile  Trp Ser Gly Ala Ser  Phe Asp Leu 
    1625                 1630                 1635             


Ser Pro  Gly Leu Gln Arg Ile  Leu Asp Lys Val Ser  Ser Pro Leu 
    1640                 1645                 1650             


Glu Asn  Glu Lys Leu Lys Ser  Met Thr Ile Asn Phe  Ser Ser Leu 
    1655                 1660                 1665             


Asn Arg  Lys Asn Thr Glu Leu  Asn Glu Glu Gln Glu  Val Ile Ser 
    1670                 1675                 1680             


Asn Leu  Glu Thr Lys Gln Val  Gln Gly Ile Ser Phe  Ser Ser Asn 
    1685                 1690                 1695             


Asn Glu  Val Lys Ser Lys Ile  Glu Met Leu Glu Asn  Asn Ala Asn 
    1700                 1705                 1710             


His Asp  Glu Thr Ser Ser Leu  Leu Pro Arg Lys Glu  Ser Asn Ile 
    1715                 1720                 1725             


Val Asp  Asp Asn Gly Leu Ile  Pro Pro Thr Pro Ile  Pro Thr Ser 
    1730                 1735                 1740             


Ala Ser  Lys Leu Thr Phe Pro  Gly Ile Leu Glu Thr  Pro Val Asn 
    1745                 1750                 1755             


Pro Trp  Lys Thr Asn Asn Val  Leu Gln Pro Gly Glu  Ser Tyr Leu 
    1760                 1765                 1770             


Phe Gly  Ser Pro Ser Asp Ile  Lys Asn His Asp Leu  Ser Pro Gly 
    1775                 1780                 1785             


Ser Arg  Asn Gly Phe Lys Asp  Asn Ser Pro Ile Ser  Asp Thr Ser 
    1790                 1795                 1800             


Phe Ser  Leu Gln Leu Ser Gln  Asp Gly Leu Gln Leu  Thr Pro Ala 
    1805                 1810                 1815             


Ser Ser  Ser Ser Glu Ser Leu  Ser Ile Ile Asp Val  Ala Ser Asp 
    1820                 1825                 1830             


Gln Asn  Leu Phe Gln Thr Phe  Ile Lys Glu Trp Arg  Cys Lys Lys 
    1835                 1840                 1845             


Arg Phe  Ser Ile Ser Leu Ala  Cys Glu Lys Ile Arg  Ser Leu Thr 
    1850                 1855                 1860             


Ser Ser  Lys Thr Ala Thr Ile  Gly Ser Arg Phe Lys  Gln Ala Ser 
    1865                 1870                 1875             


Ser Pro  Gln Glu Ile Pro Ile  Arg Asp Asp Gly Phe  Pro Ile Lys 
    1880                 1885                 1890             


Gly Cys  Asp Asp Thr Leu Val  Val Gly Leu Ala Val  Cys Trp Gly 
    1895                 1900                 1905             


Gly Arg  Asp Ala Tyr Tyr Phe  Ser Leu Gln Lys Glu  Gln Lys His 
    1910                 1915                 1920             


Ser Glu  Ile Ser Ala Ser Leu  Val Pro Pro Ser Leu  Asp Pro Ser 
    1925                 1930                 1935             


Leu Thr  Leu Lys Asp Arg Met  Trp Tyr Leu Gln Ser  Cys Leu Arg 
    1940                 1945                 1950             


Lys Glu  Ser Asp Lys Glu Cys  Ser Val Val Ile Tyr  Asp Phe Ile 
    1955                 1960                 1965             


Gln Ser  Tyr Lys Ile Leu Leu  Leu Ser Cys Gly Ile  Ser Leu Glu 
    1970                 1975                 1980             


Gln Ser  Tyr Glu Asp Pro Lys  Val Ala Cys Trp Leu  Leu Asp Pro 
    1985                 1990                 1995             


Asp Ser  Gln Glu Pro Thr Leu  His Ser Ile Val Thr  Ser Phe Leu 
    2000                 2005                 2010             


Pro His  Glu Leu Pro Leu Leu  Glu Gly Met Glu Thr  Ser Gln Gly 
    2015                 2020                 2025             


Ile Gln  Ser Leu Gly Leu Asn  Ala Gly Ser Glu His  Ser Gly Arg 
    2030                 2035                 2040             


Tyr Arg  Ala Ser Val Glu Ser  Ile Leu Ile Phe Asn  Ser Met Asn 
    2045                 2050                 2055             


Gln Leu  Asn Ser Leu Leu Gln  Lys Glu Asn Leu Gln  Asp Val Phe 
    2060                 2065                 2070             


Arg Lys  Val Glu Met Pro Ser  Gln Tyr Cys Leu Ala  Leu Leu Glu 
    2075                 2080                 2085             


Leu Asn  Gly Ile Gly Phe Ser  Thr Ala Glu Cys Glu  Ser Gln Lys 
    2090                 2095                 2100             


His Ile  Met Gln Ala Lys Leu  Asp Ala Ile Glu Thr  Gln Ala Tyr 
    2105                 2110                 2115             


Gln Leu  Ala Gly His Ser Phe  Ser Phe Thr Ser Ser  Asp Asp Ile 
    2120                 2125                 2130             


Ala Glu  Val Leu Phe Leu Glu  Leu Lys Leu Pro Pro  Asn Arg Glu 
    2135                 2140                 2145             


Met Lys  Asn Gln Gly Ser Lys  Lys Thr Leu Gly Ser  Thr Arg Arg 
    2150                 2155                 2160             


Gly Ile  Asp Asn Gly Arg Lys  Leu Arg Leu Gly Arg  Gln Phe Ser 
    2165                 2170                 2175             


Thr Ser  Lys Asp Val Leu Asn  Lys Leu Lys Ala Leu  His Pro Leu 
    2180                 2185                 2190             


Pro Gly  Leu Ile Leu Glu Trp  Arg Arg Ile Thr Asn  Ala Ile Thr 
    2195                 2200                 2205             


Lys Val  Val Phe Pro Leu Gln  Arg Glu Lys Cys Leu  Asn Pro Phe 
    2210                 2215                 2220             


Leu Gly  Met Glu Arg Ile Tyr  Pro Val Ser Gln Ser  His Thr Ala 
    2225                 2230                 2235             


Thr Gly  Arg Ile Thr Phe Thr  Glu Pro Asn Ile Gln  Asn Val Pro 
    2240                 2245                 2250             


Arg Asp  Phe Glu Ile Lys Met  Pro Thr Leu Val Gly  Glu Ser Pro 
    2255                 2260                 2265             


Pro Ser  Gln Ala Val Gly Lys  Gly Leu Leu Pro Met  Gly Arg Gly 
    2270                 2275                 2280             


Lys Tyr  Lys Lys Gly Phe Ser  Val Asn Pro Arg Cys  Gln Ala Gln 
    2285                 2290                 2295             


Met Glu  Glu Arg Ala Ala Asp  Arg Gly Met Pro Phe  Ser Ile Ser 
    2300                 2305                 2310             


Met Arg  His Ala Phe Val Pro  Phe Pro Gly Gly Ser  Ile Leu Ala 
    2315                 2320                 2325             


Ala Asp  Tyr Ser Gln Leu Glu  Leu Arg Ile Leu Ala  His Leu Ser 
    2330                 2335                 2340             


His Asp  Arg Arg Leu Ile Gln  Val Leu Asn Thr Gly  Ala Asp Val 
    2345                 2350                 2355             


Phe Arg  Ser Ile Ala Ala Glu  Trp Lys Met Ile Glu  Pro Glu Ser 
    2360                 2365                 2370             


Val Gly  Asp Asp Leu Arg Gln  Gln Ala Lys Gln Ile  Cys Tyr Gly 
    2375                 2380                 2385             


Ile Ile  Tyr Gly Met Gly Ala  Lys Ser Leu Gly Glu  Gln Met Gly 
    2390                 2395                 2400             


Ile Lys  Glu Asn Asp Ala Ala  Cys Tyr Ile Asp Ser  Phe Lys Ser 
    2405                 2410                 2415             


Arg Tyr  Thr Gly Ile Asn Gln  Phe Met Thr Glu Thr  Val Lys Asn 
    2420                 2425                 2430             


Cys Lys  Arg Asp Gly Phe Val  Gln Thr Ile Leu Gly  Arg Arg Arg 
    2435                 2440                 2445             


Tyr Leu  Pro Gly Ile Lys Asp  Asn Asn Pro Tyr Arg  Lys Ala His 
    2450                 2455                 2460             


Ala Glu  Arg Gln Ala Ile Asn  Thr Ile Val Gln Gly  Ser Ala Ala 
    2465                 2470                 2475             


Asp Ile  Val Lys Ile Ala Thr  Val Asn Ile Gln Lys  Gln Leu Glu 
    2480                 2485                 2490             


Thr Phe  His Ser Thr Phe Lys  Ser His Gly His Arg  Glu Gly Met 
    2495                 2500                 2505             


Leu Gln  Ser Asp Gln Thr Gly  Leu Ser Arg Lys Arg  Lys Leu Gln 
    2510                 2515                 2520             


Gly Met  Phe Cys Pro Ile Arg  Gly Gly Phe Phe Ile  Leu Gln Leu 
    2525                 2530                 2535             


His Asp  Glu Leu Leu Tyr Glu  Val Ala Glu Glu Asp  Val Val Gln 
    2540                 2545                 2550             


Val Ala  Gln Ile Val Lys Asn  Glu Met Glu Ser Ala  Val Lys Leu 
    2555                 2560                 2565             


Ser Val  Lys Leu Lys Val Lys  Val Lys Ile Gly Ala  Ser Trp Gly 
    2570                 2575                 2580             


Glu Leu  Lys Asp Phe Asp Val  
    2585                 2590 


<210>  11
<211>  2536
<212>  PRT
<213>  T. chinensis

<400>  11

Met Asn Leu Leu Arg Arg Ser Gly Lys Arg Arg Arg Thr Asp Ser Gly 
1               5                   10                  15      


Ser Asp Ser Phe Ser Gly Ser Gly Gly Asp Ser Cys Ala Ser Thr Val 
            20                  25                  30          


Leu Leu Ser Lys Gln Leu Gly Cys Gly Gln Ile Pro Leu Pro Gly Glu 
        35                  40                  45              


Gly Arg Ala Pro Thr Arg Val Gln Tyr Ser Leu Gln Ile Leu Asn Pro 
    50                  55                  60                  


Gly Glu Cys Lys Gln Thr Asp Pro Asp Asp Pro Ile Asp Lys Leu Leu 
65                  70                  75                  80  


Leu Ala Asn Trp Gly Leu Pro Lys Ala Val Leu Glu Lys Tyr His Ser 
                85                  90                  95      


Phe Gly Val Lys Lys Met Phe Glu Trp Gln Ala Glu Cys Leu Leu Leu 
            100                 105                 110         


Gly Gln Val Leu Glu Gly Lys Asn Leu Val Tyr Ser Ala Pro Thr Ser 
        115                 120                 125             


Ala Gly Lys Thr Leu Val Ala Glu Leu Leu Ile Leu Lys Arg Val Leu 
    130                 135                 140                 


Glu Met Arg Lys Lys Ala Leu Phe Ile Leu Pro Phe Val Ser Val Ala 
145                 150                 155                 160 


Lys Glu Lys Lys Tyr Tyr Leu Gln Ser Leu Phe Gln Glu Val Gly Ile 
                165                 170                 175     


Lys Val Asp Gly Tyr Val Gly Ser Thr Ser Pro Thr Gly His Phe Ser 
            180                 185                 190         


Ser Leu Asp Ile Ala Val Cys Thr Ile Glu Arg Ala Asn Gly Leu Ile 
        195                 200                 205             


Asn Arg Leu Ile Glu Glu Asn Lys Met Asp Leu Leu Gly Met Val Val 
    210                 215                 220                 


Val Asp Glu Leu His Met Leu Gly Asp Ser His Arg Gly Tyr Leu Leu 
225                 230                 235                 240 


Glu Leu Leu Leu Thr Lys Ile Cys Tyr Ile Thr Gln Lys Ser Ala Ser 
                245                 250                 255     


Cys Gln Ala Asp Leu Val Ser Pro Leu Phe Asn Gly Val Gln Ile Val 
            260                 265                 270         


Gly Met Ser Ala Thr Leu Pro Asn Leu Asp Leu Ile Ala Ser Trp Leu 
        275                 280                 285             


Asn Ala Glu Leu Tyr His Thr Asp Phe Arg Pro Val Pro Leu Leu Glu 
    290                 295                 300                 


Thr Val Lys Ile Gly Asn Ser Ile Tyr Asp Ser Ser Met Lys Leu Val 
305                 310                 315                 320 


Arg Glu Phe Gln Pro Met Leu Gln Val Lys Gly Asp Glu Asp His Ile 
                325                 330                 335     


Val Ser Leu Cys Tyr Glu Thr Ile Cys Asp Asn His Ser Val Leu Leu 
            340                 345                 350         


Phe Cys Pro Ser Lys Lys Trp Cys Glu Lys Leu Ala Asp Thr Ile Ala 
        355                 360                 365             


Arg Glu Phe Tyr Asn Leu His His Gln Ala Glu Gly Leu Val Lys Pro 
    370                 375                 380                 


Pro Glu Phe Pro Pro Val Thr Leu Glu Pro Lys Gly Leu Gln Glu Val 
385                 390                 395                 400 


Met Asp Gln Leu Lys His Leu Pro Ser Gly Leu Asp Ser Val Leu Gln 
                405                 410                 415     


Lys Thr Val Pro Trp Gly Val Ala Phe His His Ala Gly Leu Thr Phe 
            420                 425                 430         


Glu Glu Arg Asp Ile Ile Glu Gly Ala Phe Arg Gln Gly Leu Ile Arg 
        435                 440                 445             


Val Leu Ala Ala Thr Ser Thr Leu Ser Ser Gly Val Asn Leu Pro Ala 
    450                 455                 460                 


Arg Arg Val Ile Ile Arg Thr Pro Ile Phe Ser Gly Arg Pro Leu Asp 
465                 470                 475                 480 


Val Leu Thr Tyr Lys Gln Met Val Gly Arg Ala Gly Arg Lys Gly Val 
                485                 490                 495     


Asp Thr Val Gly Glu Ser Ile Leu Val Cys Lys Ile Ser Glu Lys Ser 
            500                 505                 510         


Lys Gly Thr Ala Leu Leu Gln Gly Ser Leu Lys Pro Val Cys Ser Cys 
        515                 520                 525             


Leu Arg Arg His Glu Gly Glu Glu Val Thr Ala Cys Met Ile Arg Ala 
    530                 535                 540                 


Ile Leu Glu Ile Ile Val Gly Gly Val Ala Ser Thr Pro Gln Asp Met 
545                 550                 555                 560 


Gln Asn Tyr Ala Ser Cys Thr Phe Leu Ala Ala Ser Met Lys Glu Gly 
                565                 570                 575     


Gln Gln Glu Ile Glu Arg Asn Gln Asn Ser Val Gln Leu Gly Ala Ile 
            580                 585                 590         


Glu Ala Cys Val Met Trp Leu Leu Glu Asn Glu Phe Ile Gln Val Ala 
        595                 600                 605             


Glu Val Gly Asp Gly Thr Glu Gly Lys Val Tyr His Pro Thr His Leu 
    610                 615                 620                 


Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser Pro Thr Asp Thr Leu Asp 
625                 630                 635                 640 


Ile Phe Ala Asp Leu Gln Arg Ala Met Lys Gly Phe Val Leu Glu Asn 
                645                 650                 655     


Asp Leu His Ile Val Tyr Leu Ile Thr Pro Met Phe Glu Asp Trp Thr 
            660                 665                 670         


Thr Ile Asp Trp Tyr Arg Phe Phe Cys Leu Trp Glu Lys Leu Pro Ile 
        675                 680                 685             


Ser Met Lys Arg Val Ala Glu Leu Val Gly Val Glu Glu Gly Phe Leu 
    690                 695                 700                 


Ala Arg Cys Val Lys Gly Lys Val Val Ala Arg Thr Glu Arg Gln His 
705                 710                 715                 720 


Arg Gln Met Ala Ile His Lys Arg Phe Phe Thr Ser Leu Val Leu Leu 
                725                 730                 735     


Asp Leu Ile Ser Glu Val Pro Leu Lys Glu Ile Asn Gln Lys Tyr Gly 
            740                 745                 750         


Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln Gln Ser Ala Ala Val Tyr 
        755                 760                 765             


Ala Gly Met Ile Thr Val Phe Ser Asn Arg Leu Gly Trp His Asn Met 
    770                 775                 780                 


Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg Leu Thr Phe Gly Ile Gln 
785                 790                 795                 800 


Arg Glu Leu Cys Asp Leu Val Arg Val Ser Leu Leu Asn Ala Gln Arg 
                805                 810                 815     


Ala Arg Ala Leu Tyr Ala Ser Gly Phe Leu Thr Val Ala Asp Leu Ala 
            820                 825                 830         


Arg Ala Asn Ile Ala Asp Val Glu Met Val Leu Lys Asn Ala Val Pro 
        835                 840                 845             


Phe Lys Ser Ala Arg Lys Ala Val Asp Glu Glu Glu Asp Ala Ala Glu 
    850                 855                 860                 


Glu Arg Arg Asn Met Gln Thr Ile Trp Val Thr Gly Arg Lys Gly Leu 
865                 870                 875                 880 


Thr Glu Arg Glu Ala Ala Ala Leu Ile Val Glu Glu Ala Lys Met Ile 
                885                 890                 895     


Leu Gln Glu Asp Leu Val Glu Met Gly Val Gln Trp Asn Pro His Ser 
            900                 905                 910         


Pro Leu Asn Ser Ser Lys Leu Ser Leu Thr Ser Ser Asp Ser Glu Val 
        915                 920                 925             


Lys Glu Leu Ile Phe Ile Pro Gln Thr Gln Ser Ser Cys Lys Arg Leu 
    930                 935                 940                 


Ile Ser Lys Asn Lys Ser Asn Ser Ile Phe Ser Asp Ser Tyr Val Lys 
945                 950                 955                 960 


Arg Ser Leu Asn Thr Val Gln Asp Leu Asp Lys Ser Arg Glu Arg His 
                965                 970                 975     


Thr Ser Pro Ile Tyr Lys Phe Gln Asp Lys Asn Gln Glu Tyr Gln Arg 
            980                 985                 990         


His Ser Ile Ser Lys Arg Ala Cys  Leu Asp Ile Ser Lys  Glu Lys Pro 
        995                 1000                 1005             


Gly Thr  Ser Leu Asn Glu Gly  Arg Lys Ser Thr Gln  Lys Ala Val 
    1010                 1015                 1020             


Gln Thr  Phe Ser Phe Glu Lys  Thr Lys Ile Ala Ser  Asn Phe Ser 
    1025                 1030                 1035             


Ser Asp  Lys Met Ser Thr Ser  Phe Arg Ser Trp Lys  His Arg Lys 
    1040                 1045                 1050             


His Leu  Lys Gln Ser Arg Ser  Ser Ser Ser Val Lys  Asp Ser Ser 
    1055                 1060                 1065             


Ile Ser  Arg Thr Asp Leu Gln  Arg Trp Arg Lys Ser  Ser Pro Ile 
    1070                 1075                 1080             


Leu Cys  Glu Asp Pro Ser Ala  Leu Gly Glu Arg Asn  Val Glu Phe 
    1085                 1090                 1095             


Arg Ser  Pro Gly Pro Phe Ala  Lys Asn Val Ser Phe  Cys Val Glu 
    1100                 1105                 1110             


Arg Lys  Tyr Asp Gln Thr Glu  Gln Ser Cys Thr Arg  Ser Gly Ala 
    1115                 1120                 1125             


Ile Ser  Asn Asp Ile Phe Val  Glu His Phe Asp Thr  Gly Ser Gln 
    1130                 1135                 1140             


Ser Lys  Thr Met Ala Cys Gln  Thr Phe Gly Val Val  Ser Glu Asn 
    1145                 1150                 1155             


Gly Arg  Gly Leu Ala Ile Val  Glu Thr Glu Lys Ile  Asn Lys Val 
    1160                 1165                 1170             


Leu Ile  Gln Asn Asp Ser Lys  Asn Gln Asn Val Asn  Leu Lys Tyr 
    1175                 1180                 1185             


Cys Val  Thr His Pro Val Asn  Gln Asp Leu Gly Lys  Gln Cys Asp 
    1190                 1195                 1200             


Gln Gln  Thr Asp Thr Cys Thr  Lys Gln Lys Glu Ile  Thr Glu Arg 
    1205                 1210                 1215             


Gln Met  Pro Phe Glu Ala Val  Ser Ser Asn Thr Asn  Gly Asp Ser 
    1220                 1225                 1230             


Asp Val  Thr Ser Val Lys Cys  Lys Ser Val Lys Phe  Asn Ser Glu 
    1235                 1240                 1245             


Glu Asn  Lys Pro Ser His Phe  Gln Ala Phe Gly Asn  Asn Ile Ser 
    1250                 1255                 1260             


Arg Thr  Gln Ile Pro Ser Glu  Ile Gln Val Leu Thr  Gly Thr Phe 
    1265                 1270                 1275             


Arg Glu  Ser Gly Gly Gln His  Asp Ser Phe Gln Asn  Thr Ser Lys 
    1280                 1285                 1290             


Ile Gln  Glu Lys Ala Cys Ala  Tyr Leu Thr Asn Lys  Thr Glu Asn 
    1295                 1300                 1305             


Asn Asn  Val Ser Asp Leu Gly  Leu Val Leu Cys Asp  Phe Glu Asp 
    1310                 1315                 1320             


Ser Phe  Tyr Leu Asp Thr Gln  Ser Glu Lys Ile Ile  Gln Glu Ile 
    1325                 1330                 1335             


Ala Thr  Glu Asn Ala Lys Gln  Ala Ala Glu Asp Pro  Asn Leu Ala 
    1340                 1345                 1350             


Ala Glu  Lys Met Gln Thr Asn  Val Gln Lys Gln Asn  Leu Ile Ser 
    1355                 1360                 1365             


Ser Phe  Gln Asn Ala Leu Cys  Val Thr Leu Pro Gly  Glu Gln His 
    1370                 1375                 1380             


Ser Pro  Gly Val Thr Asn Thr  Glu Pro Leu Asp His  Lys Thr Gly 
    1385                 1390                 1395             


Asp Thr  Arg His Lys Pro Ser  Thr Asp Ser Cys Arg  Val Asp Ile 
    1400                 1405                 1410             


Leu Thr  Arg Glu Asn Ser Val  Phe His Ser Pro Ile  Leu Leu Glu 
    1415                 1420                 1425             


Glu Asn  Ser Pro Cys Phe Lys  Gly Asn Glu Leu Ser  Val Thr Asp 
    1430                 1435                 1440             


Ser Gln  Leu Asn Asn Phe Leu  Gln Gly Tyr Gln Thr  Gln Glu Thr 
    1445                 1450                 1455             


Val Lys  Pro Gly Ile Pro Val  Val Pro Gln Lys Glu  Thr Pro Thr 
    1460                 1465                 1470             


Ala Met  Glu Gly Glu Cys Leu  Pro Val Pro Glu Thr  Ser Leu Asn 
    1475                 1480                 1485             


Met Ser  Asp Ser Leu Leu Phe  Asp Ser Phe Asn Glu  Asp Tyr Leu 
    1490                 1495                 1500             


Val Lys  Glu Gln Pro Ala Lys  Val Gln Ala Lys Glu  Thr Phe Leu 
    1505                 1510                 1515             


Thr Thr  Glu Ile Thr Ser Asp  His Phe Ser Asp Ser  Leu Asn Ile 
    1520                 1525                 1530             


Arg Glu  Gly Pro Ala Lys Thr  Ser Asp Ile Asn Gly  Asn Gln Asp 
    1535                 1540                 1545             


Ile His  Gln Gln Leu Thr Cys  Phe Asn Asp Glu Ser  Leu Met Phe 
    1550                 1555                 1560             


Ser Glu  Met Asp Ser Ala Gln  Val Val Glu Val Leu  Asp Lys Leu 
    1565                 1570                 1575             


Asp Ile  Phe Pro Ile Gln Glu  Lys His Asn Thr Ala  Val Ser Leu 
    1580                 1585                 1590             


Ser Thr  Leu Lys Leu Ser Asp  Pro Val Ile Val Val  Asn Asn His 
    1595                 1600                 1605             


Arg Gln  Gly Glu Val Ile Gly  Gly Glu Gln Asp Glu  Lys Ala Gln 
    1610                 1615                 1620             


Gln Ser  Lys Ile Thr Glu Thr  Gly Gln Asn Asn Ser  Phe Met Trp 
    1625                 1630                 1635             


Ser Gly  Ala Ser Phe Asp Leu  Ser Pro Gly Leu Gln  Arg Ile Leu 
    1640                 1645                 1650             


Asp Lys  Val Ser Ser Pro Leu  Glu Asn Glu Met Leu  Lys Ser Met 
    1655                 1660                 1665             


Pro Ile  Asn Leu Ser Ser Leu  Lys Gly Lys Asn Arg  Glu Leu Asn 
    1670                 1675                 1680             


Glu Lys  Gln Glu Val Ile Ser  Asn Leu Asp Thr Ser  Gln Met Gln 
    1685                 1690                 1695             


Arg Ile  Ser Cys Phe His Thr  Asn Glu Val Lys Asn  Asn Ile Ala 
    1700                 1705                 1710             


Pro Glu  Asn Ser Val Asn His  Gly Ala His Leu Ser  Pro Leu Ser 
    1715                 1720                 1725             


Phe Lys  Glu Ser Cys Ile Val  Asp Asp Asn Gly Leu  Ile Pro Pro 
    1730                 1735                 1740             


Thr Pro  Val Pro Ala Ser Ala  Ser Lys Phe Ser Phe  Pro Gly Ile 
    1745                 1750                 1755             


Leu Gly  Thr Ser Ala Val Leu  Gln Asn Thr Gly Ser  Val Leu Gln 
    1760                 1765                 1770             


Ser Gly  Gly Ser Tyr Leu Phe  Gly Ser Pro Ser Asp  Thr Lys Asn 
    1775                 1780                 1785             


His Glu  Leu Ser Pro Asp Ser  Arg Asn Gly Phe Lys  Asp Glu Ser 
    1790                 1795                 1800             


Pro Arg  Lys Glu Lys Ser Phe  Ser Leu Gln Phe Ser  Gln Asp Gly 
    1805                 1810                 1815             


Leu Gln  Leu Thr Pro Ala Ser  Ser Asn Ser Gln Ser  Leu Ala Ile 
    1820                 1825                 1830             


Ile Asp  Val Ala Ser Asn Gln  Thr Leu Phe Gln Thr  Phe Ile Lys 
    1835                 1840                 1845             


Glu Trp  Gln Cys Lys Lys Arg  Phe Ser Ile Ser Leu  Ala Cys Glu 
    1850                 1855                 1860             


Lys Ile  Gly Ser Ser Ala Ser  Ser Lys Thr Ala Thr  Ile Gly Gly 
    1865                 1870                 1875             


Arg Phe  Lys Gln Gly Ser Ser  Ser Gln Glu Thr Pro  Ile Arg Asp 
    1880                 1885                 1890             


Gly Gly  Phe Pro Val Lys Gly  His Glu Asp Ile Leu  Val Val Gly 
    1895                 1900                 1905             


Leu Ala  Val Cys Trp Gly Gly  Arg Asp Ala Tyr Tyr  Phe Ser Leu 
    1910                 1915                 1920             


Gln Gln  Glu Gln Lys His Ser  Glu Ile Ser Ala Ser  Leu Asn Pro 
    1925                 1930                 1935             


Pro Pro  Leu Asp Pro Gly Leu  Thr Val Lys Asp Arg  Leu Trp His 
    1940                 1945                 1950             


Leu Gln  Ser Cys Leu Gln Lys  Lys Ser Gly Lys Glu  Cys Ser Val 
    1955                 1960                 1965             


Ile Ile  Tyr Asp Phe Ile Gln  Ser Tyr Lys Ile Leu  Leu Leu Ser 
    1970                 1975                 1980             


Cys Gly  Ile Ser Leu Glu Gln  Asp Phe Glu Asp Pro  Lys Val Ala 
    1985                 1990                 1995             


Cys Trp  Leu Leu Asp Pro Asp  Ser Lys Glu Pro Thr  Leu His Ser 
    2000                 2005                 2010             


Ile Val  Thr Ser Phe Leu Pro  His Glu Leu Pro Leu  Leu Glu Gly 
    2015                 2020                 2025             


Met Glu  Thr Gly Glu Gly Ile  Gln Ser Leu Gly Leu  Asn Val Asn 
    2030                 2035                 2040             


Thr Glu  His Ser Gly Arg Tyr  Arg Ala Ser Val Glu  Ser Val Leu 
    2045                 2050                 2055             


Ile Phe  Ser Cys Met Thr Gln  Leu Asn Ser Leu Leu  Gln Lys Glu 
    2060                 2065                 2070             


Asn Leu  Gln Asp Val Phe Cys  Lys Val Glu Met Pro  Ser Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Ala Leu Leu Glu Leu  Asn Gly Ile Gly Phe  Ser Thr Ala 
    2090                 2095                 2100             


Glu Cys  Glu Ser Gln Lys Gln  Ile Met Gln Ala Lys  Leu Asp Ala 
    2105                 2110                 2115             


Ile Glu  Thr Glu Ala Tyr Gln  Leu Ala Gly His Ser  Phe Ser Phe 
    2120                 2125                 2130             


Thr Ser  Ser Asp Asp Ile Ala  Glu Val Leu Phe Leu  Glu Leu Lys 
    2135                 2140                 2145             


Leu Pro  Pro Asn Gly Glu Met  Lys Asn Gln Gly Ile  Lys Lys Thr 
    2150                 2155                 2160             


Leu Gly  Ser Thr Arg Arg Gly  Ile Asp Ser Gly Arg  Lys Leu Arg 
    2165                 2170                 2175             


Leu Gly  Arg Gln Phe Ser Thr  Arg Arg Ile Thr Phe  Thr Glu Pro 
    2180                 2185                 2190             


Asn Ile  Gln Asn Val Pro Arg  Asp Phe Glu Ile Lys  Met Pro Thr 
    2195                 2200                 2205             


Leu Val  Glu Glu Ser Pro Pro  Ser Gln Ala Leu Gly  Lys Gly Leu 
    2210                 2215                 2220             


Leu Pro  Met Gly Arg Gly Lys  Ile Lys Lys Gly Arg  Arg Leu Asn 
    2225                 2230                 2235             


Pro Glu  His Gln Ala His Leu  Glu Glu Arg Ala Ser  Asp Lys Gly 
    2240                 2245                 2250             


Met Pro  Phe Ser Val Ser Met  Arg His Ala Phe Val  Pro Phe Pro 
    2255                 2260                 2265             


Gly Gly  Leu Ile Leu Ala Ala  Asp Tyr Ser Gln Leu  Glu Leu Arg 
    2270                 2275                 2280             


Ile Leu  Ala His Leu Ser His  Asp His Arg Leu Ile  Gln Val Leu 
    2285                 2290                 2295             


Asn Thr  Gly Ala Asp Val Phe  Arg Ser Ile Ala Ala  Glu Trp Lys 
    2300                 2305                 2310             


Met Ile  Glu Pro Glu Thr Val  Gly Asn Glu Leu Arg  Gln Gln Ala 
    2315                 2320                 2325             


Lys Gln  Ile Cys Tyr Gly Ile  Ile Tyr Gly Met Gly  Ala Lys Ser 
    2330                 2335                 2340             


Leu Gly  Glu Gln Met Gly Ile  Lys Glu Asn Asp Ala  Ala Cys Tyr 
    2345                 2350                 2355             


Ile Asp  Ser Phe Lys Ser Arg  Tyr Thr Gly Ile Asn  His Phe Met 
    2360                 2365                 2370             


Arg Glu  Thr Val Lys Asn Cys  Lys Arg Asp Gly Phe  Val Gln Thr 
    2375                 2380                 2385             


Ile Leu  Gly Arg Arg Arg Tyr  Leu Pro Gly Ile Lys  Asp Asn Asn 
    2390                 2395                 2400             


Pro Tyr  His Lys Ala His Ala  Glu Arg Gln Ala Ile  Asn Thr Thr 
    2405                 2410                 2415             


Val Gln  Gly Ser Ala Ala Asp  Ile Val Lys Val Ala  Thr Val Asn 
    2420                 2425                 2430             


Ile Gln  Lys Gln Leu Glu Thr  Leu Arg Ser Thr Phe  Lys Ser His 
    2435                 2440                 2445             


Gly His  Arg Glu Ser Met Leu  Arg Arg Asp Lys Thr  Gly Leu Leu 
    2450                 2455                 2460             


Pro Lys  Arg Lys Leu Gln Gly  Met Phe Cys Pro Ile  Arg Gly Gly 
    2465                 2470                 2475             


Phe Phe  Ile Leu Gln Leu His  Asp Glu Leu Leu Tyr  Glu Val Ala 
    2480                 2485                 2490             


Glu Glu  Asp Ala Val Gln Val  Ala Gln Ile Val Lys  Asn Glu Met 
    2495                 2500                 2505             


Glu Asn  Ala Ile Lys Leu Ser  Val Lys Leu Lys Val  Lys Val Lys 
    2510                 2515                 2520             


Ile Gly  Ala Ser Trp Ala Glu  Leu Arg Asp Phe Asp  Val 
    2525                 2530                 2535     


<210>  12
<211>  2383
<212>  PRT
<213>  C. griseus

<400>  12

Met Arg Lys Lys Ala Leu Phe Ile Leu Pro Phe Val Ser Val Ala Lys 
1               5                   10                  15      


Glu Lys Lys Tyr Tyr Leu Gln Ser Leu Phe Gln Glu Val Gly Ile Lys 
            20                  25                  30          


Val Asp Gly Tyr Met Gly Ser Ser Ser Pro Thr Gly Arg Phe Ser Ser 
        35                  40                  45              


Leu Asp Ile Ala Val Cys Thr Ile Glu Arg Ala Asn Gly Leu Ile Asn 
    50                  55                  60                  


Arg Leu Ile Glu Glu Asn Lys Met Asp Leu Leu Gly Met Val Val Val 
65                  70                  75                  80  


Asp Glu Leu His Met Leu Gly Asp Ser His Arg Gly Tyr Leu Leu Glu 
                85                  90                  95      


Leu Leu Leu Thr Lys Ile Cys Tyr Val Thr Arg Lys Ser Thr Leu Cys 
            100                 105                 110         


Gln Ala Asp Ser Ala Arg Ala Leu Cys Asn Ala Val Gln Ile Val Gly 
        115                 120                 125             


Met Ser Ala Thr Leu Pro Asn Leu Gln Leu Val Ala Ser Trp Leu Asp 
    130                 135                 140                 


Ala Glu Leu Tyr His Thr Asp Phe Arg Pro Val Pro Leu Leu Glu Ser 
145                 150                 155                 160 


Ile Lys Ile Gly Asn Ser Ile Tyr Asp Ser Ser Met Lys Leu Val Arg 
                165                 170                 175     


Glu Leu Gln Pro Val Leu Gln Val Lys Gly Asp Glu Asp His Ile Val 
            180                 185                 190         


Ser Leu Cys Tyr Glu Thr Val Cys Asp Asn His Ser Val Leu Leu Phe 
        195                 200                 205             


Cys Pro Ser Lys Lys Trp Cys Glu Lys Val Ala Asp Ile Ile Ala Arg 
    210                 215                 220                 


Glu Phe Tyr Asn Leu His His Gln Pro Glu Arg Leu Val Lys Pro Ser 
225                 230                 235                 240 


Glu Phe Pro Pro Val Asn Leu Asp Gln Lys Ser Leu Leu Glu Val Met 
                245                 250                 255     


Asp Gln Leu Lys Arg Ser Pro Ser Gly Leu Asp Ser Val Leu Lys Asn 
            260                 265                 270         


Thr Val Pro Trp Gly Val Ala Phe His His Ala Gly Leu Thr Phe Glu 
        275                 280                 285             


Glu Arg Asp Ile Ile Glu Gly Ala Phe Arg Gln Gly Leu Ile Arg Val 
    290                 295                 300                 


Leu Ala Ala Thr Ser Thr Leu Ser Ser Gly Val Asn Leu Pro Ala Arg 
305                 310                 315                 320 


Arg Val Ile Ile Arg Thr Pro Val Phe Gly Gly Gln Thr Leu Asp Ile 
                325                 330                 335     


Leu Thr Tyr Lys Gln Met Val Gly Arg Ala Gly Arg Lys Gly Val Asp 
            340                 345                 350         


Thr Met Ala Ala Val Tyr Asp Asp Phe Gln Ile Ile Val Gly Gly Val 
        355                 360                 365             


Ala Ser Thr Ser Gln Asp Met Gln Thr Tyr Ala Ser Cys Thr Phe Leu 
    370                 375                 380                 


Ala Ala Ala Val Lys Glu Gly Lys Gln Gly Ile Gln Arg Asn Gln Asp 
385                 390                 395                 400 


Asp Val His Phe Gly Ala Ile Asp Ala Cys Val Thr Trp Leu Leu Glu 
                405                 410                 415     


Asn Glu Phe Ile Gln Glu Ala Glu Pro Ser Asp Gly Ser Gly Gly Lys 
            420                 425                 430         


Val Tyr His Pro Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu 
        435                 440                 445             


Ser Pro Thr Asp Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met 
    450                 455                 460                 


Lys Gly Phe Val Leu Glu Asn Asp Leu His Ile Val Tyr Leu Val Thr 
465                 470                 475                 480 


Pro Val Phe Glu Asp Trp Thr Gly Ile Asp Trp Tyr Arg Phe Phe Cys 
                485                 490                 495     


Leu Trp Glu Lys Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val 
            500                 505                 510         


Gly Val Glu Glu Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val 
        515                 520                 525             


Ala Arg Thr Asp Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe 
    530                 535                 540                 


Phe Thr Ser Leu Val Leu Leu Asp Leu Ile Ser Glu Ile Pro Leu Lys 
545                 550                 555                 560 


Glu Ile Asn Gln Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu 
                565                 570                 575     


Gln Gln Ser Ala Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn 
            580                 585                 590         


Arg Leu Gly Trp His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys 
        595                 600                 605             


Arg Leu Thr Phe Gly Ile Gln Arg Glu Leu Cys Asp Leu Ile Arg Val 
    610                 615                 620                 


Ser Leu Leu Asn Ala Gln Arg Ala Arg Phe Leu Tyr Ala Ser Gly Phe 
625                 630                 635                 640 


Leu Thr Val Ala Asp Leu Ala Arg Ala Asn Val Ala Glu Val Glu Val 
                645                 650                 655     


Val Leu Lys Asn Ala Val Pro Phe Lys Ser Thr Arg Lys Ala Val Asp 
            660                 665                 670         


Glu Glu Glu Glu Ala Ala Glu Glu Arg Arg Asn Met Gln Thr Ile Trp 
        675                 680                 685             


Val Ser Gly Arg Lys Gly Leu Ser Ala Arg Glu Ala Ala Thr Leu Ile 
    690                 695                 700                 


Val Glu Glu Ala Lys Thr Ile Leu Gln Gln Asp Leu Leu Glu Met Gly 
705                 710                 715                 720 


Val Gln Trp Asp Pro Asn Ser Ser Leu Ser Ser Ser Thr Ser Ser Leu 
                725                 730                 735     


Thr Ser Ser Glu Ser Glu Val Asn Glu Arg Thr Leu Gln Ser Gln Thr 
            740                 745                 750         


Lys Asn Ser His Lys Arg Leu Thr Ser Lys Asn Arg Asn Ser Met Arg 
        755                 760                 765             


Ala Ser Val Ser Asn Asp Lys Pro Ser Pro Asp Thr Ala Gln Gly Leu 
    770                 775                 780                 


Gly Glu His Ser Glu His Thr Asp Ser Leu Cys Leu Leu Gln Gly Asn 
785                 790                 795                 800 


Lys His Gln His Gln Pro His Ser Val Cys Arg Ala Arg Lys Arg Thr 
                805                 810                 815     


Ser Leu Gly Ile Asn Lys Glu Lys Leu Arg Met Ser Leu Asn Gly Gly 
            820                 825                 830         


Glu Pro Ser Thr Lys Glu Val Leu Gln Thr Phe Ser Met Glu Lys Thr 
        835                 840                 845             


Arg Lys Ala Ala Leu Thr Ala Asn Ser Glu Gln Thr Asn Thr Ser Phe 
    850                 855                 860                 


Pro Ser Trp Arg Asp Arg Lys His Arg Lys Lys Ser Trp Gly Ser Ser 
865                 870                 875                 880 


Pro Val Arg Asp Ser Arg Ala Asn His His Arg Asp Asp Phe Gln Glu 
                885                 890                 895     


His Thr Val Ser Arg Ser Thr Leu Cys Glu Glu Pro Leu Ser Leu Asp 
            900                 905                 910         


Lys Gln Asn Ile Glu Phe Arg Ser Ser Gly Leu Leu Ile Lys Asn Ala 
        915                 920                 925             


Ser Phe Cys Ala Asn Glu Lys Tyr Asn Lys Thr Ser Phe Ser Leu Gln 
    930                 935                 940                 


Met Gln Gln Pro Cys Leu Arg Lys Lys Thr Glu Ser Thr Gly Ala Val 
945                 950                 955                 960 


Glu His Ser Phe Ala Glu Ser Gln Ser Lys Asn Val Thr Gly Gln Ser 
                965                 970                 975     


Pro Gly Val Ala Ser Asn Gly Arg Glu Leu Ala Asp Thr Glu Thr Gly 
            980                 985                 990         


Lys Ile Asn Glu Val Leu Ile Glu  Asn Gly Ala Glu Ser  Gln Asn Val 
        995                 1000                 1005             


Ser Val  Lys His His Asp Thr  His Pro Ile Ser Gln  Cys Leu Glu 
    1010                 1015                 1020             


Asn Gln  Cys Asp Lys Gln Thr  Asn Thr Cys Thr Lys  Arg Lys Ala 
    1025                 1030                 1035             


Leu Ile  Glu Arg Gln Val Ser  Cys Glu Ala Val Ser  Tyr Met Ala 
    1040                 1045                 1050             


Arg Asp  Ser Asn Asp Val Ser  Thr Ile Asn Ser Glu  Ser Ile Lys 
    1055                 1060                 1065             


Leu His  Ser Lys Asp Asp Glu  Ser Asn His Cys Gln  Val Leu Gly 
    1070                 1075                 1080             


Asn Asn  Thr Gly Arg Ser Glu  Ala Pro Arg Gly Leu  Leu Gln Ser 
    1085                 1090                 1095             


Ala Ala  Glu Phe Ser Gln Ala  Asp Gly Gln His Glu  His Leu Leu 
    1100                 1105                 1110             


Asn Ser  Ser Gly Ile Gln Glu  Lys Thr Asp Ala Tyr  Ala Thr Asn 
    1115                 1120                 1125             


Lys Thr  Glu His Asn His Val  Ser Asn Leu Ala Pro  Cys Asp Phe 
    1130                 1135                 1140             


Gly Asp  Ser Phe Tyr Leu Asp  Thr Gln Ser Glu Lys  Ile Ile Glu 
    1145                 1150                 1155             


Gln Leu  Ala Thr Glu His Ala  Lys Gln Arg Thr Lys  Ala Val Thr 
    1160                 1165                 1170             


Ala Lys  Gly Ser Asp Thr Arg  Asn Ser Gly Ser Ser  Phe Gln Asn 
    1175                 1180                 1185             


Lys Cys  His Ser Thr Arg Gly  Glu Gln His Phe Gln  Arg Ala Ala 
    1190                 1195                 1200             


Asn Thr  Asp His Leu Asp Ser  Lys Ser Val Glu Thr  Thr Lys Gln 
    1205                 1210                 1215             


Asn Pro  Glu Lys Ser Ile Gly  Arg Leu Thr Ala Glu  Ser Ile Ile 
    1220                 1225                 1230             


Phe His  Ser Pro Thr Pro Gln  Gly Glu Asn Gly Pro  Cys Phe Arg 
    1235                 1240                 1245             


Val Asn  Glu Gln Ser Val Thr  Asp Ser Gln Leu Asn  Ser Phe Leu 
    1250                 1255                 1260             


Gln Gly  Phe Glu Thr Gln Glu  Met Val Lys Pro Val  Leu Ser Leu 
    1265                 1270                 1275             


Ala Pro  Leu Ala Gly Thr Pro  Thr Gly Leu Glu Glu  Glu Asn Leu 
    1280                 1285                 1290             


Pro Glu  Thr Ser Leu Asn Met  Ser Asp Ser Ile Leu  Phe Asp Ser 
    1295                 1300                 1305             


Phe Gly  Glu Asp Asp Leu Val  Lys Gly Gln Ser Pro  Asp Val Gln 
    1310                 1315                 1320             


Ala Lys  Gln Pro Leu Leu Ser  Val Met Thr Pro Asn  His Leu Ser 
    1325                 1330                 1335             


Ser Ser  Leu Cys Pro Arg Glu  Asp Pro Val Met Lys  Ala Asn Val 
    1340                 1345                 1350             


Asn Asp  His Gln Gly Ile Gln  Gln Pro Glu Thr Cys  Ser Ser Gly 
    1355                 1360                 1365             


Glu Ser  Val Ile Phe Ser Glu  Val Asp Ser Ala Gln  Met Ile Glu 
    1370                 1375                 1380             


Ala Leu  Asp Ser Val Ala Ala  Leu His Val Gln Gln  Asn Cys Asn 
    1385                 1390                 1395             


Ser Val  Thr Leu Lys Thr Leu  Glu Leu Ser Asp Ser  Ala Met Leu 
    1400                 1405                 1410             


Asp Asn  Glu Cys Pro Gln Gly  Lys Val Ala Arg Gly  Asp Lys Ser 
    1415                 1420                 1425             


Glu Arg  Ala Gln Met Ser Lys  Leu Thr Glu Thr Asn  Gln Asp Asn 
    1430                 1435                 1440             


Ser Ile  Thr Trp Ser Gly Ala  Ser Phe Asp Leu Ser  Pro Glu Leu 
    1445                 1450                 1455             


Gln Arg  Ile Leu Asp Lys Gly  Ser Ser Pro Leu Glu  Asn Glu Arg 
    1460                 1465                 1470             


Pro Lys  Leu Thr Gln Thr Asn  Leu Ser Cys Phe Glu  Arg Asn Gly 
    1475                 1480                 1485             


Thr Glu  Leu Asn Glu Arg Gln  Glu Met Asn Pro Asn  Leu Glu Ala 
    1490                 1495                 1500             


Val Gln  Ile Gln Arg Thr Ser  Leu Phe Pro Asn Asn  Gly Val Gln 
    1505                 1510                 1515             


Asn Lys  Ile Glu Gly Ile Gly  Asn Asp Thr Arg Arg  Gly Glu Ala 
    1520                 1525                 1530             


Leu Tyr  Pro Ser Ala Arg Lys  Glu Ser Asp Thr Ala  Asp Asp Asn 
    1535                 1540                 1545             


Gly Leu  Ile Pro Pro Thr Pro  Ile Leu Ala Ser Thr  Ser Lys Leu 
    1550                 1555                 1560             


Ser Phe  Pro Glu Ile Leu Gly  Thr Ser Val Asn His  Leu Lys Ala 
    1565                 1570                 1575             


Asp Ser  Val Phe Leu Pro Gly  Glu Ser Cys Leu Phe  Gly Ser Pro 
    1580                 1585                 1590             


Ser Asp  Ser Gln Glu Arg Arg  Asp Ser Phe Lys Asp  Asp Arg Ser 
    1595                 1600                 1605             


Val Gly  Asp Thr Ser Phe Ser  Leu Gln Phe Ser Gln  Asp Glu Leu 
    1610                 1615                 1620             


Gln Leu  Thr Pro Ala Ser Cys  Ser Ser Glu Ser Leu  Ala Ile Ile 
    1625                 1630                 1635             


Asp Val  Ala Ser Asp His Thr  Leu Phe Glu Thr Phe  Val Lys Glu 
    1640                 1645                 1650             


Trp Arg  Cys Gln Lys Arg Phe  Ser Ile Ser Leu Ala  Cys Glu Lys 
    1655                 1660                 1665             


Ile Arg  Ser Pro Thr Ser Ser  Lys Thr Ala Thr Ile  Gly Gly Arg 
    1670                 1675                 1680             


Leu Lys  Gln Val Ser Ser Pro  Gln Lys Thr Ser Ala  Glu Asp Asp 
    1685                 1690                 1695             


Gly Phe  Pro Val His Gly Ser  Asp Gly Val Ile Val  Val Gly Leu 
    1700                 1705                 1710             


Ala Val  Cys Trp Gly Gly Arg  Asp Ala Tyr Tyr Leu  Ser Leu Gln 
    1715                 1720                 1725             


Lys Glu  Gln Lys His Ser Val  Phe Pro Leu Arg Leu  Leu Leu Gln 
    1730                 1735                 1740             


Leu Asn  Glu Phe Asn Phe Tyr  Ile Lys Thr Val Leu  Phe Gln Glu 
    1745                 1750                 1755             


Ile Ser  Pro Ser Leu Ala Pro  Pro Pro Leu Asp Thr  Thr Leu Thr 
    1760                 1765                 1770             


Val Glu  Glu Arg Met Glu His  Leu Gln Ser Cys Leu  Gln Lys Lys 
    1775                 1780                 1785             


Ser Asp  Lys Glu Gln Thr Val  Val Thr Tyr Asp Phe  Ile Gln Ser 
    1790                 1795                 1800             


Tyr Lys  Ile Leu Leu Leu Ser  Cys Gly Val Ser Leu  Glu Pro Ser 
    1805                 1810                 1815             


Tyr Glu  Asp Pro Lys Val Ala  Cys Trp Leu Leu Asp  Pro Asp Ser 
    1820                 1825                 1830             


Lys Glu  Pro Thr Leu His Ser  Ile Val Thr Ser Phe  Leu Pro Glu 
    1835                 1840                 1845             


Glu Leu  Pro Leu Leu Glu Gly  Ile Glu Thr Gly Gln  Gly Ile Gln 
    1850                 1855                 1860             


Ser Leu  Gly Leu Asn Val Asp  Thr Glu His Ser Gly  Arg Tyr Arg 
    1865                 1870                 1875             


Ala Ser  Val Glu Ser Ile Leu  Ile Phe Asn Ser Met  Asn Gln Leu 
    1880                 1885                 1890             


Asn Ser  Leu Leu Gln Lys Glu  Asn Leu His Asp Ile  Phe Cys Lys 
    1895                 1900                 1905             


Val Glu  Met Pro Ser Gln Tyr  Cys Leu Ala Leu Leu  Glu Leu Asn 
    1910                 1915                 1920             


Gly Ile  Gly Phe Ser Thr Ala  Glu Cys Glu Ser Gln  Lys His Ile 
    1925                 1930                 1935             


Met Gln  Ala Lys Leu Asp Ala  Ile Glu Thr Gln Ala  Tyr Gln Leu 
    1940                 1945                 1950             


Ala Gly  His Ser Phe Ser Phe  Thr Ser Ala Asp Asp  Ile Ala Gln 
    1955                 1960                 1965             


Asp Val  Leu Asn Lys Leu Lys  Ala Leu His Pro Leu  Pro Gly Leu 
    1970                 1975                 1980             


Ile Leu  Glu Trp Arg Arg Ile  Ser Asn Ala Ile Thr  Lys Val Val 
    1985                 1990                 1995             


Phe Pro  Leu Gln Arg Glu Lys  Arg Leu Asn Pro Phe  Leu Arg Met 
    2000                 2005                 2010             


Glu Arg  Leu Tyr Pro Val Ser  Gln Ser His Thr Ala  Thr Gly Arg 
    2015                 2020                 2025             


Ile Thr  Phe Ile Glu Pro Asn  Ile Gln Asn Val Pro  Arg Asp Phe 
    2030                 2035                 2040             


Glu Ile  Lys Met Pro Thr Val  Val Arg Glu Ser Pro  Pro Ser Gln 
    2045                 2050                 2055             


Ala Pro  Gly Lys Arg Leu Leu  Pro Met Thr Arg Gly  Gln Asn Lys 
    2060                 2065                 2070             


Lys Phe  Tyr Gly Leu His Pro  Gly Asn Gly Thr Leu  Met Glu Glu 
    2075                 2080                 2085             


Lys Ala  Ser Asp Arg Gly Val  Pro Phe Ser Val Ser  Met Arg His 
    2090                 2095                 2100             


Ala Phe  Val Pro Phe Pro Val  Asp Asn Leu Leu Glu  Leu Arg Ile 
    2105                 2110                 2115             


Leu Ala  His Leu Ser Arg Asp  Cys Arg Leu Ile Gln  Val Leu Asn 
    2120                 2125                 2130             


Thr Gly  Ala Asp Val Phe Arg  Ser Ile Ala Ala Glu  Trp Lys Met 
    2135                 2140                 2145             


Ile Glu  Pro Asp Ser Val Gly  Glu Asp Leu Arg Gln  Gln Ala Lys 
    2150                 2155                 2160             


Gln Ile  Cys Tyr Gly Ile Ile  Tyr Gly Met Gly Ala  Lys Ser Leu 
    2165                 2170                 2175             


Gly Glu  Gln Met Gly Ile Lys  Glu Asn Asp Ala Ala  Cys Tyr Ile 
    2180                 2185                 2190             


Asp Ser  Phe Lys Ser Arg Tyr  Thr Gly Ile Asn His  Phe Leu Arg 
    2195                 2200                 2205             


Asp Thr  Val Lys Lys Cys Arg  Arg Asp Gly Phe Val  Gln Thr Ile 
    2210                 2215                 2220             


Leu Gly  Arg Arg Arg Tyr Leu  Pro Gly Ile Lys Asp  Asn Asn Pro 
    2225                 2230                 2235             


Tyr His  Lys Ala His Ala Glu  Arg Gln Ala Ile Asn  Thr Thr Val 
    2240                 2245                 2250             


Gln Gly  Ser Ala Ala Asp Ile  Val Lys Thr Ala Thr  Val Asn Ile 
    2255                 2260                 2265             


Gln Lys  Gln Leu Glu Thr Phe  His Ser Ala Phe Lys  Ser His Gly 
    2270                 2275                 2280             


His Arg  Glu Ser Met Leu Gln  His Gly Gln Thr Gly  Cys Gly Asp 
    2285                 2290                 2295             


Leu Ser  Pro Ser Pro Gly Gln  Leu Val Gly Leu Leu  Pro Lys Lys 
    2300                 2305                 2310             


Lys Leu  Lys Gly Met Phe Cys  Pro Met Arg Gly Gly  Phe Phe Ile 
    2315                 2320                 2325             


Leu Gln  Leu His Asp Glu Leu  Leu Tyr Glu Val Ala  Glu Glu Asp 
    2330                 2335                 2340             


Val Val  Gln Val Ala Gln Ile  Val Lys Lys Glu Met  Glu Cys Ala 
    2345                 2350                 2355             


Val Lys  Leu Ser Val Lys Leu  Lys Val Lys Val Arg  Met Gly Ala 
    2360                 2365                 2370             


Ser Trp  Gly Gln Leu Glu Asp  Phe Asp Val 
    2375                 2380             


<210>  13
<211>  2530
<212>  PRT
<213>  R. norvegicus

<400>  13

Met Ser Leu Pro Arg Arg Ser Gly Lys Arg Arg Arg Ser Ser Ser Gly 
1               5                   10                  15      


Ser Asp Ser Phe Ser Phe Ser Gly Asp Gly Asp Ser Cys Val Ser Pro 
            20                  25                  30          


Gln Leu Leu Cys Arg Pro Val Leu Ser Pro Pro Pro Gly Leu Gly Arg 
        35                  40                  45              


Gly Arg Arg Leu Ala Gly Thr Gly Thr Cys Lys Gln Arg Val Ser Asp 
    50                  55                  60                  


Asp Gln Ile Asp Gln Leu Leu Leu Ala Asn Trp Gly Leu Pro Lys Ala 
65                  70                  75                  80  


Val Leu Glu Lys Tyr His Asn Phe Gly Val Lys Lys Met Phe Glu Trp 
                85                  90                  95      


Gln Ala Glu Cys Leu Leu Leu Gly Gln Val Leu Glu Gly Lys Asn Leu 
            100                 105                 110         


Val Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu 
        115                 120                 125             


Leu Ile Leu Lys Arg Val Leu Glu Thr Arg Lys Lys Ala Leu Phe Ile 
    130                 135                 140                 


Leu Pro Phe Val Ser Val Ala Lys Glu Lys Lys Tyr Tyr Leu Gln Ser 
145                 150                 155                 160 


Leu Phe Gln Glu Val Gly Ile Lys Val Asp Gly Tyr Met Gly Ser Thr 
                165                 170                 175     


Ser Pro Thr Gly Arg Phe Ser Ser Leu Asp Val Ala Val Cys Thr Ile 
            180                 185                 190         


Glu Arg Ala Asn Gly Leu Ile Asn Arg Leu Ile Glu Glu Asn Lys Met 
        195                 200                 205             


Asp Leu Leu Gly Thr Val Val Val Asp Glu Leu His Met Leu Gly Asp 
    210                 215                 220                 


Ser His Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Val Cys Phe 
225                 230                 235                 240 


Val Thr Arg Lys Ser Ala Ser Cys Gln Ala Asp Ser Ala Ser Ala Leu 
                245                 250                 255     


Ala Cys Ala Val Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu 
            260                 265                 270         


Gln Leu Val Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe 
        275                 280                 285             


Arg Pro Val Pro Leu Leu Glu Ser Ile Lys Val Gly Asn Ser Ile Tyr 
    290                 295                 300                 


Asp Ser Ser Met Lys Leu Val Arg Glu Phe Gln Pro Leu Leu Gln Val 
305                 310                 315                 320 


Lys Gly Asp Glu Asp His Ile Val Ser Leu Cys Tyr Glu Thr Val Arg 
                325                 330                 335     


Asp Asn His Ser Val Leu Val Phe Cys Pro Ser Lys Lys Trp Cys Glu 
            340                 345                 350         


Lys Val Ala Asp Ile Ile Ala Arg Glu Phe Tyr Asn Leu His His Gln 
        355                 360                 365             


Pro Glu Gly Leu Val Lys Ser Ser Glu Phe Pro Pro Val Ile Leu Asp 
    370                 375                 380                 


Gln Lys Ser Leu Leu Glu Val Ile Asp Gln Leu Lys Arg Ser Pro Ser 
385                 390                 395                 400 


Gly Leu Asp Ser Val Leu Lys Asn Thr Val Pro Trp Gly Val Ala Phe 
                405                 410                 415     


His His Ala Gly Leu Thr Phe Glu Glu Arg Asp Ile Ile Glu Gly Ala 
            420                 425                 430         


Phe Arg Gln Gly Leu Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser 
        435                 440                 445             


Ser Gly Val Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Val 
    450                 455                 460                 


Phe Gly Gly Gln Pro Leu Asp Ile Leu Thr Tyr Lys Gln Met Val Gly 
465                 470                 475                 480 


Arg Ala Gly Arg Lys Gly Val Asp Thr Met Gly Glu Ser Ile Leu Val 
                485                 490                 495     


Cys Lys Asn Ser Glu Lys Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser 
            500                 505                 510         


Leu Glu Pro Val His Ser Cys Leu Gln Ser Gln Gly Glu Val Thr Ser 
        515                 520                 525             


Thr Met Ile Arg Ala Ile Leu Glu Ile Ile Val Ser Gly Val Ala Ser 
    530                 535                 540                 


Thr Ser Gln Asp Met Gln Thr Tyr Ala Ala Cys Thr Phe Leu Ala Ala 
545                 550                 555                 560 


Asp Val Lys Glu Gly Lys Gln Gly Ile Gln Arg Asn Arg Asp Asp Val 
                565                 570                 575     


Gln Arg Gly Ala Val Asp Ala Cys Val Thr Trp Leu Leu Glu Asn Glu 
            580                 585                 590         


Phe Ile Gln Ala Ala Glu Pro Ser Asp Gly Thr Gly Gly Lys Val Tyr 
        595                 600                 605             


His Pro Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser Pro 
    610                 615                 620                 


Thr Asp Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met Lys Gly 
625                 630                 635                 640 


Phe Val Leu Glu Asn Asp Leu His Ile Val Tyr Leu Val Thr Pro Val 
                645                 650                 655     


Phe Glu Asp Trp Thr Ser Ile Asp Trp Tyr Arg Phe Phe Cys Leu Trp 
            660                 665                 670         


Glu Lys Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val Gly Val 
        675                 680                 685             


Glu Glu Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val Ala Arg 
    690                 695                 700                 


Thr Glu Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe Thr 
705                 710                 715                 720 


Ser Leu Val Leu Leu Asp Leu Ile Ser Glu Ile Pro Leu Lys Glu Ile 
                725                 730                 735     


Asn Gln Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln Gln 
            740                 745                 750         


Ser Ala Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn Arg Leu 
        755                 760                 765             


Gly Trp His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg Leu 
    770                 775                 780                 


Thr Phe Gly Ile Gln Arg Glu Leu Cys Asp Leu Ile Arg Val Ser Ser 
785                 790                 795                 800 


Leu Asn Ala Gln Arg Ala Arg Phe Leu Tyr Ala Ser Gly Phe Leu Thr 
                805                 810                 815     


Val Ala Asp Leu Ala Arg Ala Asp Thr Val Glu Val Glu Ala Ala Leu 
            820                 825                 830         


Lys Asp Ala Leu Pro Phe Lys Ser Ala Arg Lys Ala Val Asp Glu Glu 
        835                 840                 845             


Glu Glu Ala Ala Glu Glu Arg Arg Ser Met Arg Thr Ile Trp Val Ala 
    850                 855                 860                 


Gly Lys Ser Leu Ser Ala Arg Glu Ala Ala Ala Leu Ile Val Glu Glu 
865                 870                 875                 880 


Ala Lys Val Ile Leu Gln Gln Asp Leu Ile Glu Met Gly Val Gln Trp 
                885                 890                 895     


Gly Pro His Ser Pro Leu Ser Ser Ser Thr His Ser Leu Thr Ser Gly 
            900                 905                 910         


Ser Glu Val Lys Glu His Thr Phe Lys Ser Gln Thr Lys Ser Ser His 
        915                 920                 925             


Lys Arg Leu Ala Ser Lys Ser Arg Asn Ser Met Arg Val Ser Gly Ser 
    930                 935                 940                 


Asn Gly Lys Gln Ser Pro Glu Ala Gly Gln Gly Leu Asp Glu Cys Arg 
945                 950                 955                 960 


Glu Arg Pro Asp Ser Leu Cys Lys Phe Gln Gly Asn His Glu Ile Gln 
                965                 970                 975     


Thr Pro Ser Val Tyr Arg Ala Arg Lys Arg Thr Ser Leu Gly Val Asn 
            980                 985                 990         


Lys Glu Met Leu Arg Thr Ser Leu  Lys Glu Gly Lys Pro  Ser Thr Lys 
        995                 1000                 1005             


Glu Val  Leu Gln Thr Leu Ser  Phe Glu Lys Thr Arg  Lys Ala Ala 
    1010                 1015                 1020             


Leu Ser  Phe Ser Ser Glu Gln  Ala Asn Asn Ser Phe  Pro Ser Gly 
    1025                 1030                 1035             


Arg Asp  Arg Lys Tyr Arg Lys  Lys Ser Trp Gly Ser  Ser Pro Met 
    1040                 1045                 1050             


Ser Asp  Ser Val Met His Arg  Asp Asp Leu Gln Gly  Gln Thr Met 
    1055                 1060                 1065             


Cys Lys  Ser Thr Leu Cys Glu  Asp Pro Gln Lys Ser  Leu Glu Glu 
    1070                 1075                 1080             


Gln Asn  Thr Glu Tyr Arg Ser  Pro Gly Leu Phe Ala  Lys Asn Val 
    1085                 1090                 1095             


Ser Phe  Cys Ala Lys Glu Lys  Cys Asn Lys Thr Ser  Phe Pro Leu 
    1100                 1105                 1110             


Gln Met  Gln Gln Pro Cys Leu  Arg Arg Lys Pro Glu  Ser Gly Ala 
    1115                 1120                 1125             


Ala Val  Asp His Ser Val Ala  Val Ser Gln Asn Lys  Asn Val Val 
    1130                 1135                 1140             


Glu Gln  Pro Pro Gly Ala Pro  Arg Asp Arg Arg Gly  Leu Ala Ala 
    1145                 1150                 1155             


His Gly  Arg Ala Glu Val Asn  Glu Val Leu Thr Glu  Asn Gly Thr 
    1160                 1165                 1170             


Glu Ser  Gln Leu His Asp Thr  His Pro Val Ser Gln  Cys Leu Glu 
    1175                 1180                 1185             


Asn His  Ser Glu Lys Gln Thr  Asn Thr Cys Thr Arg  Gln Lys Thr 
    1190                 1195                 1200             


Leu Thr  Glu Gly Gln Ala Gly  Ile Ser His Val Thr  Arg Gly Ser 
    1205                 1210                 1215             


Asn Asp  Leu Thr Pro Ile Arg  Cys Glu Arg Leu Lys  Leu Asn Ser 
    1220                 1225                 1230             


Lys Glu  His Asp Ser Asn Pro  Cys Pro Gln Ala Leu  Gly Thr Asn 
    1235                 1240                 1245             


Ala Gly  Arg Thr Glu Ala Pro  Gln Ser Ser Glu Ala  Leu Gly Gln 
    1250                 1255                 1260             


Ala Gly  Gly Gln Cys Glu Asn  Leu Leu Asn Ser Pro  Gly Ile Gln 
    1265                 1270                 1275             


Glu Lys  Thr Ser Ala His Ala  Thr Asn Lys Thr Glu  His Ser His 
    1280                 1285                 1290             


Val Ala  Asn Gln Ala Phe Cys  Asp Phe Gly Asp Ser  Leu Tyr Leu 
    1295                 1300                 1305             


Asp Thr  Gln Ser Glu Glu Ile  Ile Glu Gln Met Ala  Thr Lys Asn 
    1310                 1315                 1320             


Ala Thr  Gln Gly Ala Glu Ala  Ala Gly Ile Thr Glu  Glu Gly Ser 
    1325                 1330                 1335             


Ala Thr  Gln Asn Glu Pro His  Ser Thr Thr Gly Gly  Gln His Ile 
    1340                 1345                 1350             


Pro Gly  Ala Ala Asn Thr Asp  His Val Asp Arg Lys  Asn Thr Glu 
    1355                 1360                 1365             


Ser Val  Lys Glu Asn Pro Glu  Lys Asn Ile Asp Arg  Arg Thr Pro 
    1370                 1375                 1380             


His Ser  Leu Ile Phe His Ser  Pro Thr Pro Gln Gly  Gly Asn Ser 
    1385                 1390                 1395             


Ala Cys  Phe Lys Glu Asn Glu  His Ser Val Thr Asp  Ser Gln Leu 
    1400                 1405                 1410             


Asn Ser  Phe Leu Gln Gly Leu  Glu Thr Gln Asp Lys  Pro Ile Ile 
    1415                 1420                 1425             


Pro Leu  Ala Pro Gln Met Arg  Thr Ser Thr Gly Val  Glu Glu Glu 
    1430                 1435                 1440             


Ser Leu  Pro Glu Thr Ser Leu  Asn Met Ser Asp Ser  Ile Leu Phe 
    1445                 1450                 1455             


Asp Ser  Phe Gly Glu Asp Ser  Phe Gly Gln Arg Gln  Ser Leu Asp 
    1460                 1465                 1470             


Val Lys  Ala Lys Gln Pro Leu  Leu Ser Glu Met Thr  Pro Asn His 
    1475                 1480                 1485             


Phe His  Asn Pro Pro Tyr Pro  Gln Glu Asp Pro Val  Met Thr Pro 
    1490                 1495                 1500             


His Met  Ser Glu Pro Gln Gly  Thr Leu Glu Arg Met  Ala Cys Leu 
    1505                 1510                 1515             


Ser Gly  Glu Ser Ile Ile Phe  Ser Glu Ile Asp Ser  Ala Gln Val 
    1520                 1525                 1530             


Ile Glu  Ala Leu Asp Asn Met  Ala Ala Phe Tyr Met  Gln Glu Asn 
    1535                 1540                 1545             


Cys Asn  Pro Ile Thr Leu Lys  Thr Glu Pro Arg Asp  Leu Ala Ala 
    1550                 1555                 1560             


Leu Gly  Asn Glu Cys Pro Gln  Gly Glu Val Val Arg  Gly Glu Gln 
    1565                 1570                 1575             


His Glu  Gly Ser Ser Lys Pro  Lys Phe Met Glu Ile  Asn Gln Asp 
    1580                 1585                 1590             


Asn Ser  Phe Thr Trp Ser Ala  Ala Ser Phe Asn Leu  Ser Pro Glu 
    1595                 1600                 1605             


Leu Gln  Arg Ile Leu Asp Lys  Val Ser Thr Pro Arg  Glu Asn Glu 
    1610                 1615                 1620             


Glu Pro  Glu Leu Met His Ala  Asp Leu Ser Cys Phe  Glu Glu Asn 
    1625                 1630                 1635             


Ser Thr  Glu Ser His Glu Arg  Gln Asp Met Asn Ser  Asp Leu Gly 
    1640                 1645                 1650             


Thr Val  Gln Arg Thr Ser Phe  Leu Pro Ser Asn Gly  Val Lys Ser 
    1655                 1660                 1665             


Arg Thr  Glu Gly Leu Glu Ser  Lys Ala Lys His Gly  Gly Ala Ser 
    1670                 1675                 1680             


Ser Ala  Leu Pro His Lys Ala  Ala Ala Asp Asp Asn  Gly Leu Ile 
    1685                 1690                 1695             


Pro Pro  Thr Pro Leu Pro Ala  Ser Ala Ser Ala Ser  Ala Ser Lys 
    1700                 1705                 1710             


Leu Ala  Leu Pro Glu Ile Leu  Gly Thr Ser Val Lys  His Gln Lys 
    1715                 1720                 1725             


Ala Ser  Cys Leu Phe Asp Ser  Pro Ser Asp Asn Gln  Asn Gln Asp 
    1730                 1735                 1740             


Leu Ser  Gln Glu Leu Arg Asp  Ser Leu Lys Asp Ser  Asp Gly Ser 
    1745                 1750                 1755             


Val Val  Asp Thr Ser Phe Phe  Leu Gln Ser Gln Asp  Gly Leu Leu 
    1760                 1765                 1770             


Leu Thr  Gln Ala Ser Cys Ser  Ser Glu Ser Leu Ala  Ile Ile Asp 
    1775                 1780                 1785             


Val Ala  Ser Asp Gln Ile Leu  Phe Gln Thr Phe Val  Lys Glu Trp 
    1790                 1795                 1800             


Gln Cys  Gln Lys Arg Phe Ser  Ile Ser Leu Ala Cys  Glu Lys Met 
    1805                 1810                 1815             


Thr Ser  Ser Thr Ser Ser Lys  Thr Ala Thr Ile Gly  Gly Arg Leu 
    1820                 1825                 1830             


Lys Gln  Val Asn Ser Pro Gln  Glu Ala Ser Val Glu  Asp Asp Gly 
    1835                 1840                 1845             


Phe Pro  Val His Gly Ser Asp  Cys Ala Val Val Val  Gly Leu Ala 
    1850                 1855                 1860             


Val Cys  Trp Gly Gly Lys Asp  Ala Tyr Tyr Leu Ser  Leu Gln Lys 
    1865                 1870                 1875             


Glu Gln  Lys Gln Ser Glu Met  Ser Pro Ser Leu Ala  Pro Pro Pro 
    1880                 1885                 1890             


Leu Asp  Ala Thr Leu Thr Val  Lys Glu Arg Met Glu  Tyr Leu Gln 
    1895                 1900                 1905             


Ser Cys  Leu Gln Lys Lys Ser  Asp Gln Glu Arg Ser  Val Val Thr 
    1910                 1915                 1920             


Tyr Asp  Phe Ile Gln Thr Tyr  Lys Val Leu Leu Leu  Ser Cys Gly 
    1925                 1930                 1935             


Ile Ser  Leu Glu Pro Ser Tyr  Glu Asp Pro Lys Val  Ala Cys Trp 
    1940                 1945                 1950             


Leu Leu  Asp Pro Asp Ser Lys  Glu Pro Thr Leu His  Ser Ile Val 
    1955                 1960                 1965             


Thr Ser  Phe Leu Pro His Glu  Leu Ala Leu Leu Glu  Gly Ile Glu 
    1970                 1975                 1980             


Thr Gly  Pro Gly Ile Gln Ser  Leu Gly Leu Asn Val  Asn Thr Asp 
    1985                 1990                 1995             


His Ser  Gly Arg Tyr Arg Ala  Ser Val Glu Ser Val  Leu Ile Phe 
    2000                 2005                 2010             


Asn Ser  Met Asn Gln Leu Asn  Ser Met Leu Gln Lys  Glu Asn Leu 
    2015                 2020                 2025             


His Asp  Ile Phe Cys Lys Val  Glu Met Pro Ser Gln  Tyr Cys Leu 
    2030                 2035                 2040             


Ala Leu  Leu Glu Leu Asn Gly  Ile Gly Phe Ser Thr  Ala Glu Cys 
    2045                 2050                 2055             


Glu Thr  Gln Lys His Ile Met  Gln Ala Lys Leu Asp  Ala Ile Glu 
    2060                 2065                 2070             


Thr Gln  Ala Tyr Gln Leu Ala  Gly His Ser Phe Ser  Phe Thr Ser 
    2075                 2080                 2085             


Ala Asp  Asp Ile Ala Gln Val  Leu Phe Leu Glu Leu  Lys Leu Pro 
    2090                 2095                 2100             


Pro Asn  Gly Glu Met Lys Thr  Gln Gly Gly Arg Lys  Thr Leu Gly 
    2105                 2110                 2115             


Ser Thr  Arg Arg Gly Thr Glu  Ser Asp Arg Lys Leu  Arg Leu Gly 
    2120                 2125                 2130             


Arg Arg  Phe Ser Thr Ser Lys  Asp Ile Leu Asn Lys  Leu Lys Asp 
    2135                 2140                 2145             


Leu His  Pro Leu Pro Gly Leu  Ile Leu Glu Trp Arg  Arg Ile Ser 
    2150                 2155                 2160             


Asn Ala  Ile Thr Lys Val Val  Phe Pro Leu Gln Arg  Glu Lys His 
    2165                 2170                 2175             


Leu Asn  Pro Phe Leu Arg Met  Glu Arg Ile Tyr Pro  Val Ser Gln 
    2180                 2185                 2190             


Ser His  Thr Ala Thr Gly Arg  Ile Thr Phe Thr Glu  Pro Asn Ile 
    2195                 2200                 2205             


Gln Asn  Val Pro Arg Asp Phe  Glu Ile Lys Met Pro  Thr Leu Val 
    2210                 2215                 2220             


Arg Glu  Ser Pro Pro Ser Gln  Ala Ser Gly Lys Gly  Gln Leu Ala 
    2225                 2230                 2235             


Met Ala  Arg Gln Asn Gln Lys  Val Tyr Gly Leu His  Pro Gly Gln 
    2240                 2245                 2250             


Arg Thr  Val Leu Glu Lys Thr  Ser Asp Arg Gly Val  Pro Phe Ser 
    2255                 2260                 2265             


Val Ser  Met Arg His Ala Phe  Val Pro Phe Pro Gly  Gly Leu Ile 
    2270                 2275                 2280             


Leu Ala  Ala Asp Tyr Ser Gln  Leu Glu Leu Arg Ile  Leu Ala His 
    2285                 2290                 2295             


Leu Ser  Arg Asp Cys Arg Leu  Ile Gln Val Leu Asn  Ser Gly Ala 
    2300                 2305                 2310             


Asp Val  Phe Arg Ser Ile Ala  Ala Glu Trp Lys Met  Ile Glu Pro 
    2315                 2320                 2325             


Asp Ala  Val Gly Asp Asn Leu  Arg Gln Gln Ala Lys  Gln Ile Cys 
    2330                 2335                 2340             


Tyr Gly  Ile Ile Tyr Gly Met  Gly Ala Lys Ser Leu  Gly Glu Gln 
    2345                 2350                 2355             


Met Gly  Ile Lys Glu Asn Asp  Ala Ala Cys Tyr Ile  Asp Ser Phe 
    2360                 2365                 2370             


Lys Ser  Arg Tyr Lys Gly Ile  Asn His Phe Met Arg  Asp Thr Val 
    2375                 2380                 2385             


Lys Asn  Cys Arg Arg Asp Gly  Phe Val Glu Thr Ile  Leu Gly Arg 
    2390                 2395                 2400             


Arg Arg  Tyr Leu Pro Gly Ile  Lys Asp Asn Asn Pro  Tyr His Lys 
    2405                 2410                 2415             


Ala His  Ala Glu Arg Gln Ala  Ile Asn Thr Thr Val  Gln Gly Ser 
    2420                 2425                 2430             


Ala Ala  Asp Ile Val Lys Val  Ala Thr Val Asn Ile  Gln Lys Gln 
    2435                 2440                 2445             


Leu Glu  Thr Phe His Pro Thr  Phe Lys Ser His Gly  His Arg Glu 
    2450                 2455                 2460             


Ser Met  Leu Gln Ser Asp Arg  Ala Gly Leu Leu Pro  Lys Arg Lys 
    2465                 2470                 2475             


Val Lys  Gly Met Phe Cys Pro  Met Arg Gly Gly Phe  Phe Ile Leu 
    2480                 2485                 2490             


Gln Leu  His Asp Glu Leu Leu  Tyr Glu Val Ala Glu  Glu Asp Val 
    2495                 2500                 2505             


Val Gln  Val Ala Gln Ile Val  Lys Asn Glu Met Glu  Cys Ala Ile 
    2510                 2515                 2520             


Lys Leu  Ser Val Lys Leu Lys  
    2525                 2530 


<210>  14
<211>  2577
<212>  PRT
<213>  A. sinensis

<400>  14

Met Ala Phe Phe Ser Lys Gly Gln Cys Gln Arg Met Asn Ile Pro Glu 
1               5                   10                  15      


Asp Gln Ala Asp Lys Leu Leu Leu Ala Ser Trp Gly Leu Pro Lys Ala 
            20                  25                  30          


Val Leu Glu Lys Tyr His Ser Leu Gly Val Val His Met Phe Lys Trp 
        35                  40                  45              


Gln Ala Glu Cys Leu Met Leu Gly Gln Val Leu Glu Gly Lys Asn Leu 
    50                  55                  60                  


Val Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu 
65                  70                  75                  80  


Leu Ile Leu Lys Arg Val Leu Glu Thr His Lys Lys Ala Leu Phe Ile 
                85                  90                  95      


Leu Pro Phe Val Ser Val Ala Lys Glu Lys Lys Tyr Tyr Leu Gln Ala 
            100                 105                 110         


Leu Phe Gln Glu Val Gly Val Arg Val Glu Gly Tyr Met Gly Ser Thr 
        115                 120                 125             


Ser Pro Ala Gly Arg Phe Ser Thr Leu Asp Val Ala Val Cys Thr Ile 
    130                 135                 140                 


Glu Arg Ala Asn Gly Leu Ile Asn Arg Leu Ile Glu Glu Asn Gln Met 
145                 150                 155                 160 


Asp Leu Leu Gly Met Val Val Val Asp Glu Leu His Met Leu Gly Asp 
                165                 170                 175     


Ser His Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Val Arg Phe 
            180                 185                 190         


Ile Thr Glu Lys Val Thr Lys Arg Gln Ala Lys Ala Ser Ser Pro Ala 
        195                 200                 205             


Phe Gly Gly Ile Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu 
    210                 215                 220                 


His Leu Leu Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe 
225                 230                 235                 240 


Arg Pro Val Pro Leu Met Glu Trp Val Lys Ile Gly Ser Asn Ile Tyr 
                245                 250                 255     


Asp Ser Ser Met Asn Leu Val Arg Glu Phe Gln Pro Met Leu Gln Leu 
            260                 265                 270         


Lys Gly Asp Glu Asp His Val Val Ser Leu Cys Tyr Glu Thr Val Arg 
        275                 280                 285             


Asp Gly His Ser Val Leu Leu Phe Cys Pro Ser Lys Asn Trp Cys Glu 
    290                 295                 300                 


Lys Leu Ala Asn Ile Ile Ala Arg Glu Phe Cys Asn Leu Gln Leu Ser 
305                 310                 315                 320 


Asp Arg Lys Thr Ser Asn Leu Pro Pro Ile Pro Leu Tyr Lys Glu Ala 
                325                 330                 335     


Ile Glu Glu Val Met Asp Gln Leu Arg Arg Ser Leu Ser Gly Leu Asp 
            340                 345                 350         


Ser Val Leu Gln Arg Thr Leu Pro Trp Gly Val Ala Phe His His Ala 
        355                 360                 365             


Gly Leu Thr Phe Asp Glu Arg Asp Val Ile Glu Gly Ala Phe Arg Gln 
    370                 375                 380                 


Gly Leu Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser Gly Val 
385                 390                 395                 400 


Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Val Phe Gly Gly 
                405                 410                 415     


Lys Leu Leu Asp Ile Leu Ala Tyr Lys Gln Met Ala Gly Arg Ala Gly 
            420                 425                 430         


Arg Lys Gly Ala Asp Thr Val Gly Glu Ser Ile Leu Val Cys Lys Pro 
        435                 440                 445             


Ser Glu Arg Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser Leu Lys Pro 
    450                 455                 460                 


Val Arg Ser Cys Leu Leu Arg Arg Glu Gly Glu Gly Ile Thr Ser Ser 
465                 470                 475                 480 


Met Ile Arg Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala Ser Thr 
                485                 490                 495     


Pro Asp Asp Val Arg Thr Tyr Ala Ser Cys Thr Leu Leu Val Ala Ser 
            500                 505                 510         


Leu Lys Asp Asn Glu Gln Gly Ser Glu Lys Asn Glu Asp Gly Val Gln 
        515                 520                 525             


Asn Gly Ala Ile Glu Ala Cys Val Ala Trp Leu Leu Gln Asn Glu Phe 
    530                 535                 540                 


Ile Gln Val Ser Gly Pro Ser Asp Gly Val Lys Ala Glu Val Tyr Cys 
545                 550                 555                 560 


Pro Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser Pro Met 
                565                 570                 575     


Glu Ala Leu Glu Ile Phe Ala Asp Leu Gln Arg Ala Met Lys Gly Phe 
            580                 585                 590         


Val Leu Glu Asn Asp Leu His Ile Val Tyr Leu Val Thr Pro Val Tyr 
        595                 600                 605             


Glu Glu Trp Thr Thr Ile Asp Trp Tyr Gln Phe Phe Cys Leu Trp Glu 
    610                 615                 620                 


Lys Leu Pro Ala Ser Met Lys Arg Val Ala Glu Leu Val Gly Ile Glu 
625                 630                 635                 640 


Glu Gly Phe Leu Ala Arg Ser Val Lys Gly Lys Ile Ile Ala Lys Thr 
                645                 650                 655     


Glu Lys Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe Thr Ser 
            660                 665                 670         


Leu Ala Leu Leu Asp Leu Ile Ser Glu Val Pro Leu Lys Asp Ile Thr 
        675                 680                 685             


Lys Arg Tyr Gly Cys Ser Arg Gly Gln Leu Gln Ser Leu Gln Gln Ser 
    690                 695                 700                 


Ala Ala Thr Tyr Ala Gly Met Val Thr Val Phe Ser Asn Arg Leu Gly 
705                 710                 715                 720 


Trp His Asn Met Glu Gln Leu Leu Ser Gln Phe Gln Ser Arg Leu Thr 
                725                 730                 735     


Phe Gly Val His Arg Glu Leu Cys Asp Leu Val Arg Val Ser Leu Leu 
            740                 745                 750         


Asn Ala Gln Arg Ala Arg Ala Leu Tyr Asn Thr Gly Phe Ile Thr Val 
        755                 760                 765             


Ala Asp Leu Ala Lys Ala Asn Pro Ala Asp Val Glu Thr Ala Leu Lys 
    770                 775                 780                 


Thr Thr Val Pro Phe Lys Ser Leu Arg Arg Ala Val Asp Glu Asp Glu 
785                 790                 795                 800 


Glu Ala Ala Glu Glu Arg Arg Asn Ala Arg Cys Ile Trp Met Ala Gly 
                805                 810                 815     


Met Lys His Val Thr Glu Asn Glu Ala Ala Ser Leu Val Val Glu Glu 
            820                 825                 830         


Ala Arg Met Leu Leu Gln Gln Asp Leu Ala Val Met Gly Val Gln Trp 
        835                 840                 845             


Asn Pro Asp Ser Tyr Leu Asp Ser Glu Ser Ser Ser Ser Met Ile Ser 
    850                 855                 860                 


Ser Glu Ser Glu Leu Glu Asp Arg Lys Tyr Arg Leu Ser Arg Glu Gly 
865                 870                 875                 880 


Ser Phe Glu Thr Leu Lys Ala Phe Asn Lys Glu Arg Tyr Gly Leu His 
                885                 890                 895     


Pro Asn Ser Gln Ser Gly Thr Ser Ala Lys Ile Glu Lys Gly Asn Lys 
            900                 905                 910         


Arg Leu Leu Gly Ala Ser Thr Pro Lys Gly Arg Leu Gln Ser Glu Ala 
        915                 920                 925             


Gln Ile Asp Gln Ile Gln Thr Glu Glu Gly Asn Ile Asp Val Ile Val 
    930                 935                 940                 


Gln Ser Ala Arg Lys Arg Pro His Leu Ser Lys Asp Lys Glu Asn Met 
945                 950                 955                 960 


Glu Phe Thr Ser Lys Arg Lys Ser Lys Ala Gly Phe Arg Glu Thr Ser 
                965                 970                 975     


Gln Glu Ser Pro Thr Glu Glu Gly Lys Arg Pro Thr Leu Ser Phe Val 
            980                 985                 990         


Pro Thr Lys Thr Ser Ala Val Cys  Arg Pro Arg Arg Ile  Met Gly Gly 
        995                 1000                 1005             


Ser Leu  Asn Gln Ser Arg Asn  Cys Ser Arg Ala Leu  Lys Gln His 
    1010                 1015                 1020             


Arg Ser  Leu Leu Glu Glu Ser  Arg Arg Gln Ile Thr  Gly Ile Lys 
    1025                 1030                 1035             


Gly Pro  Pro Leu Ser Arg His  Ser Ser Ser Glu Ser  Lys Ser Phe 
    1040                 1045                 1050             


Pro Asp  Gly Ser Asn Lys Glu  Leu Thr Glu Lys Gly  Ser Leu Val 
    1055                 1060                 1065             


His Lys  Asp Lys Ile Ser Gly  Ser Phe His Glu His  Tyr Pro Leu 
    1070                 1075                 1080             


Ile Gly  Ser Lys Glu Lys Met  Glu Gly Leu Leu Met  Glu Pro Ser 
    1085                 1090                 1095             


Val Thr  Asn Glu Cys Lys Pro  Lys Glu Lys Thr Ile  Cys Gln Ala 
    1100                 1105                 1110             


Ser Arg  Asp Val Ile Met Arg  Asp Ala Ala Thr Val  Arg Met Glu 
    1115                 1120                 1125             


Thr Ser  Asp Thr Val Gly Gly  Leu Met Ile Pro Ser  Arg Glu Leu 
    1130                 1135                 1140             


Lys Asn  Glu Asn Ile Gly Ala  Lys Asp Ser Lys Val  His Ala Gly 
    1145                 1150                 1155             


Lys Lys  Tyr Ala Lys Arg Ile  Ser Gly Lys Gln Gln  Met Ile Leu 
    1160                 1165                 1170             


Asp Thr  Asp Leu Cys Asn Glu  Ile Val Ser Ser Ser  Ala Lys Thr 
    1175                 1180                 1185             


His Val  Ser Asp Gly Ala Tyr  Lys Gln Lys Thr Val  Cys Tyr Glu 
    1190                 1195                 1200             


Pro Lys  Ser Cys Leu Phe Pro  Ile Gln Ser Lys Ser  Lys His Ser 
    1205                 1210                 1215             


Ser Glu  Ser Pro Asn Gly Val  Leu Phe Lys Ser Gly  Gly Val Gly 
    1220                 1225                 1230             


Lys Ala  Ala Asp Asn Gln Pro  Glu Asp Phe Leu Arg  Asp Ser Ile 
    1235                 1240                 1245             


Ile Lys  Ser Arg Ala Val Cys  Ile Ala Lys Ser Ser  Lys Asn Gly 
    1250                 1255                 1260             


Tyr Ala  His Asp Leu Ser Leu  Gly Tyr Gly Tyr Phe  Glu Asp Ser 
    1265                 1270                 1275             


Phe Gln  Leu Asp Thr Gln Thr  Asp Arg Ile Ile Gln  Gln Gln Val 
    1280                 1285                 1290             


Ala Ser  Glu Ile Ala Gly His  Gln Gly Ala Lys Gly  Thr Glu Leu 
    1295                 1300                 1305             


Ala Ala  Ile Ala Val Gln Lys  Thr Phe Thr Lys Leu  Pro Cys Asp 
    1310                 1315                 1320             


Asn Ala  Phe Gln Thr Glu Ser  Val Ala Asp Lys Asn  Leu Val Ala 
    1325                 1330                 1335             


Ala Phe  Arg Glu Met Asp Ser  Ser Gly Leu Val Thr  Thr Leu Gly 
    1340                 1345                 1350             


Met Lys  Gln Pro Thr Asp Leu  Cys Cys Ser Asp Lys  Thr Leu Gly 
    1355                 1360                 1365             


Ser Val  Ser Ser Cys Leu Gln  Ser Ala Val Lys Phe  Pro Asp Ala 
    1370                 1375                 1380             


Ala Leu  Cys Leu Arg Gly Asn  Asp Phe Ser Val Thr  Asp Ser Gln 
    1385                 1390                 1395             


Leu His  Ser Phe Leu Gln Gly  Tyr Leu Thr Gln Pro  Ser Val Lys 
    1400                 1405                 1410             


Glu Ser  Val Cys Leu Gly Leu  Gln Asn Gly Ala Pro  Val Ser Asn 
    1415                 1420                 1425             


Gly Gln  Asn Pro His Ile Ile  His Val Gln Val Glu  Cys His Pro 
    1430                 1435                 1440             


Ile Pro  Glu Thr Ser Leu Asn  Thr Ser Asn Ser Leu  Leu Phe Glu 
    1445                 1450                 1455             


Asp Ser  Phe Ser Asp Leu Asn  Asp Pro Ser Gly Ile  Arg Ala Gly 
    1460                 1465                 1470             


Glu Ala  Glu Gly Val Glu Thr  Arg Glu Gln Glu Ile  Leu Pro Phe 
    1475                 1480                 1485             


Pro Pro  Asn Thr Ile Ser Ser  Ser Leu Val Gly Cys  Leu His Gln 
    1490                 1495                 1500             


Gln Ser  Trp Gly Pro Ile Gln  Asp Val Trp Ser Ile  Asn Gln Val 
    1505                 1510                 1515             


Glu Glu  Gln Gln Pro Pro Gln  Cys Asn Asp Ala Ser  Leu Thr Phe 
    1520                 1525                 1530             


Ser Glu  Ile Asp Ser Phe Gln  Leu Ala Glu Ala Phe  Asp Asn Val 
    1535                 1540                 1545             


Ser Ser  Pro Pro Phe Gln Gly  Asp Leu Pro Ser Ala  Ala Leu Val 
    1550                 1555                 1560             


Glu Pro  Glu Leu Arg Lys Ser  Val Ala Gln Glu Asp  Ser Gly Pro 
    1565                 1570                 1575             


Met Asp  Ile Lys Gly Asp Lys  Ser Val Arg Pro Gln  Lys Ala Gln 
    1580                 1585                 1590             


Gln Asn  Val Lys Lys Asn Pro  Asn Ser Ile Val Trp  Ser Glu His 
    1595                 1600                 1605             


Ser Phe  Glu Leu Ser Pro Gly  Leu Gln Glu Ile Leu  Asp Lys Trp 
    1610                 1615                 1620             


Pro Ser  Pro Ser Gly Asn Lys  Pro Ala Ser Ser Ser  Pro Ser Ile 
    1625                 1630                 1635             


Pro Gly  Ser Lys Glu Lys Leu  Val Leu Ser Asn Cys  Ser Gln Glu 
    1640                 1645                 1650             


Gln Gly  Ala Val Phe Glu Phe  Gly Cys Gly Gln Lys  Lys Pro Leu 
    1655                 1660                 1665             


Pro Leu  Cys Gln Gly Leu Glu  Asn Tyr Phe Thr Gly  Arg Glu Ser 
    1670                 1675                 1680             


Asn Arg  Gly Ala Leu Glu Gln  Lys Pro Asn Cys Ser  Pro Lys Phe 
    1685                 1690                 1695             


Leu Lys  Gly Ser Ser Arg Lys  Arg Asp Pro Gln Pro  Asp Ile Ser 
    1700                 1705                 1710             


Asn Gly  Leu Ile Pro Pro Thr  Pro Pro Met Glu Pro  Ala Pro Lys 
    1715                 1720                 1725             


Ser Phe  Gly Met Ser Ser Leu  Lys Ser Gly Lys Lys  Lys Asp Val 
    1730                 1735                 1740             


Ile Leu  Met Asn Glu Gly Pro  Leu Cys Gln Val Leu  Gln Asn Gly 
    1745                 1750                 1755             


Ile Pro  Val Ser Asp Gln Gln  Ile Glu Thr Leu Gln  Phe Asn Pro 
    1760                 1765                 1770             


Glu Asn  Gly Asp Pro Leu Glu  Ile Asp Pro Val Lys  Glu Asp Ser 
    1775                 1780                 1785             


Val Ile  Asp Gln Asp Phe Ser  Leu Gln Leu Ser Gln  Asp Ile Leu 
    1790                 1795                 1800             


Pro Leu  Ile Ser Cys Ser Ala  Glu Ser Phe Thr Ile  Ile Asp Val 
    1805                 1810                 1815             


Ala Ser  Asp Met Ala Leu Phe  Gln Thr Phe Ile Gln  Glu Trp Arg 
    1820                 1825                 1830             


Asn Lys  Asn Arg Phe Ala Ile  Ser Val Ala Cys Glu  Arg Thr Lys 
    1835                 1840                 1845             


Arg Leu  Leu Ser Ser Arg Ser  Thr Ile Gly Gly Arg  Phe Lys Gln 
    1850                 1855                 1860             


Val Arg  Ser Pro Gln Gln Ile  Gln Val Lys Asp Asp  Gly Phe Pro 
    1865                 1870                 1875             


Ile Lys  Gly Cys Glu Asp Thr  Leu Ile Val Gly Leu  Ala Val Cys 
    1880                 1885                 1890             


Trp Gly  Gly Lys Asp Ala Tyr  Tyr Val Ser Leu Gln  Gln Lys Ala 
    1895                 1900                 1905             


Asp Asp  Gln Ala Glu Val Ser  Ala Ser Leu Ala Pro  Pro Ala Leu 
    1910                 1915                 1920             


Asp Gln  Asn Leu Ser Val Thr  Glu Arg Leu Cys His  Leu Gln Ser 
    1925                 1930                 1935             


Cys Leu  Gln Lys Glu Pro Glu  Gly Lys His Cys Leu  Val Met Tyr 
    1940                 1945                 1950             


Asp Phe  Ile Gln His Tyr Lys  Thr Leu Leu Met Ala  Cys Gly Ile 
    1955                 1960                 1965             


Ser Leu  Glu Gly Ser Phe Glu  Asp Pro Lys Val Ala  Cys Trp Leu 
    1970                 1975                 1980             


Leu Asp  Pro Gly Ser Lys Glu  Arg Thr Leu His Asn  Met Val Thr 
    1985                 1990                 1995             


Ser Phe  Leu Pro His Glu Leu  Pro Leu Leu Glu Gly  Ile Gly Thr 
    2000                 2005                 2010             


Gly Gln  Gly Val Gln Ser Leu  Gly Leu Ser Ala Ser  Ala Asp His 
    2015                 2020                 2025             


Ser Gly  Arg Tyr Arg Ala Ala  Val Glu Ser Val Leu  Ile Phe Gly 
    2030                 2035                 2040             


Ile Met  Asn Gln Leu Asn Thr  Leu Leu Gln Lys Glu  Asn Leu Thr 
    2045                 2050                 2055             


Asp Ala  Phe Cys Lys Val Glu  Met Pro Thr Gln Tyr  Cys Leu Ala 
    2060                 2065                 2070             


Leu Leu  Glu Leu Asn Gly Ile  Gly Phe Ser Thr Val  Ala Cys Glu 
    2075                 2080                 2085             


Thr Gln  Lys His Ile Met Gln  Ala Lys Leu Asn Glu  Ile Glu Thr 
    2090                 2095                 2100             


Gln Ala  Tyr Gln Leu Ala Gly  His Ser Phe Ser Leu  Thr Ser Pro 
    2105                 2110                 2115             


Asp Asp  Ile Ala Glu Val Leu  Phe Leu Glu Leu Lys  Leu Pro Asn 
    2120                 2125                 2130             


Gly Asp  Val Lys Ala Gln Gly  Asn Lys Lys Thr Leu  Gly Tyr Thr 
    2135                 2140                 2145             


Arg Arg  Cys Thr Thr Lys Gly  His Arg Ile Arg Leu  Gly Lys Gln 
    2150                 2155                 2160             


Phe Ser  Thr Thr Lys Asp Ala  Leu Glu Lys Leu Lys  Thr Leu His 
    2165                 2170                 2175             


Pro Leu  Pro Gly Leu Ile Leu  Glu Trp Arg Arg Ile  Thr Asn Ala 
    2180                 2185                 2190             


Val Thr  Lys Val Val Phe Pro  Leu Gln Arg Glu Lys  Arg Leu Asn 
    2195                 2200                 2205             


Ser Leu  Leu Gly Met Glu Arg  Ile Tyr Pro Ile Ser  Gln Thr His 
    2210                 2215                 2220             


Thr Ala  Thr Gly Arg Ile Ser  Phe Ala Glu Pro Asn  Ile Gln Asn 
    2225                 2230                 2235             


Val Pro  Lys Asp Phe Glu Ile  Glu Met Pro Thr Leu  Val Glu Glu 
    2240                 2245                 2250             


Ser Pro  Pro Ser Gln Ala Arg  Arg Asn Val Ser Ala  Leu Pro Gly 
    2255                 2260                 2265             


Ala Arg  Ser Arg Lys His His  Ser Ile Leu Pro Gln  Gly Ser Asn 
    2270                 2275                 2280             


Ser Val  Ala Glu Glu Gly Pro  Lys Gly Arg Gly Met  Pro Phe Ser 
    2285                 2290                 2295             


Val Ser  Met Arg His Ala Phe  Val Pro Phe Pro Gly  Gly Leu Ile 
    2300                 2305                 2310             


Leu Ala  Ala Asp Tyr Ser Gln  Ile Glu Leu Arg Ile  Leu Ala His 
    2315                 2320                 2325             


Leu Ser  Gly Asp Arg Arg Leu  Ile Gln Ala Leu Asn  Ser Gly Ala 
    2330                 2335                 2340             


Asp Val  Phe Lys Ser Ile Ala  Ala Glu Trp Lys Met  Ile Asp Pro 
    2345                 2350                 2355             


Glu Ala  Val Arg Asp Asp Thr  Arg Gln Gln Ala Lys  Gln Ile Cys 
    2360                 2365                 2370             


Tyr Gly  Ile Ile Tyr Gly Ile  Gly Ala Lys Ser Leu  Gly Glu Gln 
    2375                 2380                 2385             


Met Gly  Val Glu Glu Asn Asp  Ala Ala Ser Tyr Ile  Asp Ser Phe 
    2390                 2395                 2400             


Lys Ser  Arg Tyr Lys Gly Ile  Gln Lys Phe Leu Arg  Glu Thr Val 
    2405                 2410                 2415             


Asn Asn  Cys Ser Arg Asp Gly  Phe Val Lys Thr Ile  Leu Gly Arg 
    2420                 2425                 2430             


Arg Arg  Tyr Leu Pro Ala Ile  Arg Asp Pro Asn Pro  Tyr Ser Lys 
    2435                 2440                 2445             


Ala His  Ala Glu Arg Gln Ala  Val Asn Thr Thr Val  Gln Gly Ser 
    2450                 2455                 2460             


Ala Ala  Asp Leu Val Lys Thr  Ala Thr Val Asn Ile  Gln Arg Arg 
    2465                 2470                 2475             


Leu Glu  Ala Phe Pro Ser Thr  Ile Lys Ser His Gly  His Leu Glu 
    2480                 2485                 2490             


Ser Ser  Phe Gln Met Asp Arg  Ala Gly Arg Leu Glu  Arg Arg Arg 
    2495                 2500                 2505             


Asn Arg  Arg Met Leu His Pro  Ile Thr Gly Gly Phe  Phe Ile Leu 
    2510                 2515                 2520             


Gln Leu  His Asp Glu Leu Leu  Tyr Glu Val Ala Glu  Asp Asp Val 
    2525                 2530                 2535             


Ile Gln  Val Ala Gln Ile Val  Lys His Glu Met Glu  Asn Ala Met 
    2540                 2545                 2550             


Lys Leu  Ser Val Lys Leu Asn  Val Lys Val Arg Ile  Gly Pro Ser 
    2555                 2560                 2565             


Trp Gly  Asp Leu Gln Asp Leu  Glu Leu 
    2570                 2575         


<210>  15
<211>  2596
<212>  PRT
<213>  P. troglodytes

<400>  15

Met Asn Leu Leu Arg Arg Ser Gly Lys Arg Arg Arg Ser Glu Ser Gly 
1               5                   10                  15      


Ser Asp Ser Phe Ser Gly Ser Gly Gly Asp Ser Ser Asp Ser Pro Gln 
            20                  25                  30          


Leu Leu Ser Gly Ser Val Leu Ser Pro Pro Pro Gly Leu Gly Arg Cys 
        35                  40                  45              


Leu Lys Asp Arg Gly Arg Gln Ser Ala Ala Ala Ala Gly Glu Cys Lys 
    50                  55                  60                  


Pro Thr Val Pro Asp Tyr Glu Ile Asp Lys Leu Leu Leu Ala Asn Trp 
65                  70                  75                  80  


Gly Leu Pro Lys Ala Val Leu Glu Lys Tyr His Ser Phe Gly Val Lys 
                85                  90                  95      


Lys Met Phe Glu Trp Gln Ala Glu Cys Leu Leu Leu Gly Gln Val Leu 
            100                 105                 110         


Glu Gly Lys Asn Leu Val Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr 
        115                 120                 125             


Leu Val Ala Glu Leu Leu Ile Leu Lys Arg Val Leu Glu Met Arg Lys 
    130                 135                 140                 


Lys Ala Leu Phe Ile Leu Pro Phe Val Ser Val Ala Lys Glu Lys Lys 
145                 150                 155                 160 


Tyr Tyr Leu Gln Ser Leu Phe Gln Glu Val Gly Ile Lys Val Asp Gly 
                165                 170                 175     


Tyr Met Gly Ser Thr Ser Pro Ser Arg His Phe Ser Ser Leu Asp Ile 
            180                 185                 190         


Ala Val Cys Thr Ile Glu Arg Ala Asn Gly Leu Ile Asn Arg Leu Ile 
        195                 200                 205             


Glu Glu Asn Lys Met Asp Leu Leu Gly Met Val Val Val Asp Glu Leu 
    210                 215                 220                 


His Met Leu Gly Asp Ser His Arg Gly Tyr Leu Leu Glu Leu Leu Leu 
225                 230                 235                 240 


Thr Lys Ile Cys Tyr Ile Thr Arg Lys Ser Ala Ser Cys Gln Ala Asp 
                245                 250                 255     


Leu Ala Ser Ser Leu Ser Asn Ala Val Gln Ile Val Gly Met Ser Ala 
            260                 265                 270         


Thr Leu Pro Asn Leu Glu Leu Val Ala Ser Trp Leu Asn Ala Glu Leu 
        275                 280                 285             


Tyr His Thr Asp Phe Arg Pro Val Pro Leu Leu Glu Ser Val Lys Val 
    290                 295                 300                 


Gly Asn Ser Ile Tyr Asp Ser Ser Met Lys Leu Val Arg Glu Phe Glu 
305                 310                 315                 320 


Pro Met Leu Gln Val Lys Gly Asp Glu Asp His Val Val Ser Leu Cys 
                325                 330                 335     


Tyr Glu Thr Ile Arg Asp Asn His Ser Val Leu Leu Phe Cys Pro Ser 
            340                 345                 350         


Lys Lys Trp Cys Glu Lys Leu Ala Asp Ile Ile Ala Arg Glu Phe Tyr 
        355                 360                 365             


Asn Leu His His Gln Ala Glu Gly Leu Val Lys Pro Ser Glu Cys Pro 
    370                 375                 380                 


Pro Val Ile Leu Glu Gln Lys Glu Leu Leu Glu Val Met Asp Gln Leu 
385                 390                 395                 400 


Arg Arg Leu Pro Ser Gly Leu Asp Ser Val Leu Gln Lys Thr Val Pro 
                405                 410                 415     


Trp Gly Val Ala Phe His His Ala Gly Leu Thr Phe Glu Glu Arg Asp 
            420                 425                 430         


Ile Ile Glu Gly Ala Phe Arg Gln Gly Leu Ile Arg Val Leu Ala Ala 
        435                 440                 445             


Thr Ser Thr Leu Ser Ser Gly Val Asn Leu Pro Ala Arg Arg Val Ile 
    450                 455                 460                 


Ile Arg Thr Pro Ile Phe Gly Gly Arg Pro Leu Asp Ile Leu Thr Tyr 
465                 470                 475                 480 


Lys Gln Met Val Gly Arg Ala Gly Arg Lys Gly Val Asp Thr Val Gly 
                485                 490                 495     


Glu Ser Ile Leu Ile Cys Lys Asn Ser Glu Lys Ser Lys Gly Ile Ala 
            500                 505                 510         


Leu Leu Gln Gly Ser Leu Lys Pro Val Arg Ser Cys Leu Gln Arg Arg 
        515                 520                 525             


Glu Gly Glu Glu Val Thr Ala Ser Met Ile Arg Ala Ile Leu Glu Ile 
    530                 535                 540                 


Ile Val Gly Gly Val Ala Ser Thr Ser Gln Asp Met His Thr Tyr Ala 
545                 550                 555                 560 


Ala Cys Thr Phe Leu Ala Ala Ser Met Lys Glu Gly Lys Gln Gly Ile 
                565                 570                 575     


Gln Arg Asn Gln Glu Ser Val Gln Leu Gly Ala Ile Glu Ala Cys Val 
            580                 585                 590         


Met Trp Leu Leu Glu Asn Glu Phe Ile Gln Ser Thr Glu Ala Ser Asp 
        595                 600                 605             


Gly Thr Glu Gly Lys Val Tyr His Pro Thr His Leu Gly Ser Ala Thr 
    610                 615                 620                 


Leu Ser Ser Ser Leu Ser Pro Ala Asp Thr Leu Asp Ile Phe Ala Asp 
625                 630                 635                 640 


Leu Gln Arg Ala Met Lys Gly Phe Val Leu Glu Asn Asp Leu His Ile 
                645                 650                 655     


Leu Tyr Leu Val Thr Pro Met Phe Glu Asp Trp Thr Thr Ile Asp Trp 
            660                 665                 670         


Tyr Arg Phe Phe Cys Leu Trp Glu Lys Leu Pro Thr Ser Met Lys Arg 
        675                 680                 685             


Val Ala Glu Leu Val Gly Val Glu Glu Gly Phe Leu Ala Arg Cys Val 
    690                 695                 700                 


Lys Gly Lys Val Val Ala Arg Thr Glu Arg Gln His Arg Gln Met Ala 
705                 710                 715                 720 


Ile His Lys Arg Phe Phe Thr Ser Leu Val Leu Leu Asp Leu Ile Ser 
                725                 730                 735     


Glu Val Pro Leu Arg Glu Ile Asn Gln Lys Tyr Gly Cys Asn Arg Gly 
            740                 745                 750         


Gln Ile Gln Ser Leu Gln Gln Ser Ala Ala Val Tyr Ala Gly Met Ile 
        755                 760                 765             


Thr Val Phe Ser Asn Arg Leu Gly Trp His Asn Met Glu Leu Leu Leu 
    770                 775                 780                 


Ser Gln Phe Gln Lys Arg Leu Thr Phe Gly Ile Gln Arg Glu Leu Cys 
785                 790                 795                 800 


Asp Leu Val Arg Val Ser Leu Leu Asn Ala Gln Arg Ala Arg Val Leu 
                805                 810                 815     


Tyr Ala Ser Gly Phe His Thr Val Ala Asp Leu Ala Arg Ala Asn Ile 
            820                 825                 830         


Val Glu Val Glu Val Ile Leu Lys Asn Ala Val Pro Phe Lys Ser Ala 
        835                 840                 845             


Arg Lys Ala Val Asp Glu Glu Glu Glu Ala Val Glu Glu Arg Arg Asn 
    850                 855                 860                 


Met Arg Thr Ile Trp Val Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu 
865                 870                 875                 880 


Ala Ala Ala Leu Ile Val Glu Glu Ala Arg Met Ile Leu Gln Gln Asp 
                885                 890                 895     


Leu Val Glu Met Gly Val Gln Trp Asn Pro Cys Ala Leu Leu His Ser 
            900                 905                 910         


Ser Thr Cys Ser Leu Thr His Ser Glu Ser Glu Val Lys Glu His Thr 
        915                 920                 925             


Phe Ile Ser Gln Thr Lys Ser Ser Tyr Lys Lys Leu Thr Ser Lys Asn 
    930                 935                 940                 


Lys Ser Asn Thr Ile Phe Ser Asp Ser Tyr Ile Lys His Ser Pro Asn 
945                 950                 955                 960 


Ile Val Gln Asp Leu Asn Lys Ser Arg Glu His Thr Ser Ser Phe Asn 
                965                 970                 975     


Cys Asn Phe Gln Asn Gly Asn Gln Glu His Gln Arg Cys Ser Ile Phe 
            980                 985                 990         


Arg Ala Arg Lys Arg Ala Ser Leu  Asp Ile Asn Lys Glu  Lys Pro Gly 
        995                 1000                 1005             


Ala Ser  Gln Asn Glu Gly Glu  Thr Ser Asp Lys Lys  Val Val Gln 
    1010                 1015                 1020             


Thr Phe  Ser Arg Lys Thr Lys  Lys Ala Pro Leu Asn  Phe Asn Ser 
    1025                 1030                 1035             


Glu Lys  Met Ser Arg Ser Phe  Arg Ser Trp Lys His  Arg Lys His 
    1040                 1045                 1050             


Leu Lys  Arg Ser Arg Asp Ser  Ser Pro Leu Lys Asp  Ser Gly Ala 
    1055                 1060                 1065             


Cys Arg  Ile His Leu Gln Gly  Gln Thr Leu Ser Asn  Pro Ser Leu 
    1070                 1075                 1080             


Cys Glu  Asp Pro Phe Thr Leu  Asp Glu Lys Lys Thr  Glu Phe Arg 
    1085                 1090                 1095             


Asn Ser  Gly Pro Phe Ala Lys  Asn Val Ser Leu Ser  Gly Lys Glu 
    1100                 1105                 1110             


Lys Asp  Asn Lys Thr Ser Phe  Pro Leu Gln Ile Lys  Gln Asn Cys 
    1115                 1120                 1125             


Ser Trp  Asn Ile Thr Leu Thr  Asn Asp Asn Phe Val  Glu His Ile 
    1130                 1135                 1140             


Val Thr  Gly Ser Gln Ser Lys  Asn Val Thr Cys Gln  Ala Thr Ser 
    1145                 1150                 1155             


Val Val  Ser Glu Lys Gly Arg  Gly Val Ala Val Glu  Ala Glu Lys 
    1160                 1165                 1170             


Ile Asn  Glu Val Leu Ile Gln  Asn Gly Ser Lys Asn  Gln Asn Val 
    1175                 1180                 1185             


Tyr Ile  Lys His His Asp Ile  His Pro Ile Asn Gln  Tyr Leu Arg 
    1190                 1195                 1200             


Lys Gln  Ser His Glu Gln Thr  Ser Thr Ile Thr Lys  Gln Lys Asn 
    1205                 1210                 1215             


Ile Ile  Glu Arg Gln Met Pro  Cys Glu Ala Val Ser  Ser Tyr Ile 
    1220                 1225                 1230             


Asn Arg  Asp Ser Asn Val Thr  Ile Asn Cys Glu Arg  Ile Lys Leu 
    1235                 1240                 1245             


Asn Thr  Glu Glu Asn Lys Pro  Ser His Phe Gln Ala  Leu Gly Asp 
    1250                 1255                 1260             


Asp Ile  Ser Arg Thr Val Ile  Pro Ser Glu Val Leu  Pro Ser Ala 
    1265                 1270                 1275             


Gly Ala  Phe Ser Lys Ser Glu  Gly Gln His Glu Asn  Phe Leu Asn 
    1280                 1285                 1290             


Ile Ser  Arg Leu Gln Glu Lys  Thr Gly Thr Tyr Thr  Thr Asn Lys 
    1295                 1300                 1305             


Thr Lys  Asn Asn His Val Ser  Asp Leu Gly Leu Val  Leu Cys Asp 
    1310                 1315                 1320             


Phe Glu  Asp Ser Phe Tyr Leu  Asp Thr Gln Ser Glu  Lys Ile Ile 
    1325                 1330                 1335             


Gln Gln  Met Ala Thr Glu Asn  Ala Lys Leu Gly Ala  Lys Asp Thr 
    1340                 1345                 1350             


Asn Leu  Ala Ala Gly Ile Met  Gln Lys Ser Leu Val  Gln Gln Asn 
    1355                 1360                 1365             


Ser Met  Asn Ser Phe Gln Lys  Glu Cys His Ile Pro  Phe Pro Ala 
    1370                 1375                 1380             


Glu Gln  His Pro Leu Gly Ala  Thr Lys Ile Asp His  Leu Asp Leu 
    1385                 1390                 1395             


Lys Thr  Val Gly Thr Met Lys  Gln Ser Thr Asp Ser  His Gly Val 
    1400                 1405                 1410             


Asp Ile  Leu Thr Pro Glu Ser  Pro Ile Phe His Ser  Pro Ile Leu 
    1415                 1420                 1425             


Leu Glu  Glu Asn Gly Leu Phe  Leu Lys Lys Asn Glu  Val Ser Val 
    1430                 1435                 1440             


Thr Asp  Ser Gln Leu Asn Ser  Phe Leu Gln Gly Tyr  Gln Thr Gln 
    1445                 1450                 1455             


Glu Thr  Val Lys Pro Val Ile  Pro Leu Ile Pro Gln  Lys Arg Thr 
    1460                 1465                 1470             


Pro Thr  Gly Val Glu Gly Glu  Cys Leu Pro Val Pro  Glu Thr Ser 
    1475                 1480                 1485             


Leu Asn  Met Ser Asp Ser Leu  Leu Phe Asp Ser Phe  Ser Asp Asp 
    1490                 1495                 1500             


Tyr Leu  Val Lys Glu Gln Leu  Pro Asp Met Gln Met  Lys Glu Pro 
    1505                 1510                 1515             


Leu Pro  Ser Glu Val Thr Ser  Asn His Phe Ser Asp  Ser Leu Cys 
    1520                 1525                 1530             


Leu Gln  Glu Asp Leu Ile Arg  Lys Ser Asn Val Asn  Glu Asn Gln 
    1535                 1540                 1545             


Asp Thr  His Gln Gln Leu Thr  Cys Ser Asn Asp Glu  Ser Ile Ile 
    1550                 1555                 1560             


Phe Ser  Glu Met Asp Ser Val  Gln Met Val Glu Ala  Leu Asp Asn 
    1565                 1570                 1575             


Ala Asp  Ile Phe Pro Val Gln  Glu Lys Asn His Thr  Val Val Ser 
    1580                 1585                 1590             


Pro Arg  Ala Leu Glu Leu Ser  Asp Pro Val Leu Asp  Glu His His 
    1595                 1600                 1605             


Gln Gly  Asp Gln Asp Gly Gly  Asp Gln Asp Glu Arg  Ala Glu Lys 
    1610                 1615                 1620             


Ser Lys  Leu Thr Gly Thr Arg  Gln Asn His Ser Phe  Ile Trp Ser 
    1625                 1630                 1635             


Gly Ala  Ser Phe Asp Leu Ser  Pro Gly Leu Gln Arg  Ile Leu Asp 
    1640                 1645                 1650             


Lys Val  Ser Ser Pro Leu Glu  Asn Glu Lys Leu Lys  Ser Met Thr 
    1655                 1660                 1665             


Ile Asn  Phe Ser Ser Leu Asn  Arg Lys Asn Thr Glu  Leu Asn Glu 
    1670                 1675                 1680             


Glu Gln  Glu Val Ile Ser Asn  Leu Glu Thr Lys Gln  Val Gln Gly 
    1685                 1690                 1695             


Ile Ser  Phe Ser Ser Asn Asn  Glu Val Lys Ser Lys  Ile Glu Met 
    1700                 1705                 1710             


Leu Glu  Asn Asn Ala Asn His  Asp Glu Thr Ser Ser  Leu Leu Pro 
    1715                 1720                 1725             


Arg Lys  Glu Ser Asn Ile Val  Asp Asp Asn Gly Leu  Ile Pro Pro 
    1730                 1735                 1740             


Thr Pro  Ile Pro Thr Ser Ala  Ser Lys Leu Thr Phe  Pro Gly Ile 
    1745                 1750                 1755             


Leu Glu  Thr Pro Val Asn Pro  Trp Lys Thr Asn Asn  Val Leu Gln 
    1760                 1765                 1770             


Pro Gly  Glu Ser Tyr Leu Phe  Gly Ser Pro Ser Asp  Ile Lys Asn 
    1775                 1780                 1785             


His Asp  Leu Ser Pro Gly Ser  Arg Asn Gly Phe Lys  Asp Asn Ser 
    1790                 1795                 1800             


Pro Ile  Ser Asp Thr Ser Phe  Ser Leu Gln Leu Ser  Gln Asp Gly 
    1805                 1810                 1815             


Leu Gln  Leu Thr Pro Ala Ser  Ser Ser Ser Glu Ser  Leu Ala Ile 
    1820                 1825                 1830             


Ile Asp  Val Ala Ser Asp Gln  Asn Leu Phe Gln Thr  Phe Ile Lys 
    1835                 1840                 1845             


Glu Trp  Arg Cys Lys Lys Arg  Phe Ser Ile Ser Leu  Ala Cys Glu 
    1850                 1855                 1860             


Lys Ile  Arg Ser Leu Thr Ser  Ser Lys Thr Ala Thr  Ile Gly Ser 
    1865                 1870                 1875             


Arg Phe  Lys Gln Ala Ser Ser  Pro Gln Glu Ile Pro  Ile Arg Asp 
    1880                 1885                 1890             


Asp Gly  Phe Pro Ile Lys Gly  Cys Asp Asp Ile Leu  Val Val Gly 
    1895                 1900                 1905             


Leu Ala  Val Cys Trp Gly Gly  Arg Asp Ala Tyr Tyr  Phe Ser Leu 
    1910                 1915                 1920             


Gln Lys  Glu Gln Lys His Ser  Glu Ile Ser Ala Ser  Leu Val Pro 
    1925                 1930                 1935             


Pro Ser  Leu Asp Pro Ser Leu  Thr Leu Lys Asp Arg  Met Trp Tyr 
    1940                 1945                 1950             


Leu Gln  Ser Cys Leu Arg Lys  Glu Ser Asp Lys Glu  Cys Ser Val 
    1955                 1960                 1965             


Val Ile  Tyr Asp Phe Ile Gln  Ser Tyr Lys Ile Leu  Leu Leu Ser 
    1970                 1975                 1980             


Cys Gly  Ile Ser Leu Glu Gln  Ser Tyr Glu Asp Pro  Lys Val Ala 
    1985                 1990                 1995             


Cys Trp  Leu Leu Asp Pro Asp  Ser Gln Glu Pro Thr  Leu His Ser 
    2000                 2005                 2010             


Ile Val  Thr Ser Phe Leu Pro  His Glu Leu Pro Leu  Leu Glu Gly 
    2015                 2020                 2025             


Met Glu  Thr Ser Gln Gly Ile  Gln Ser Leu Gly Leu  Asn Ala Gly 
    2030                 2035                 2040             


Ser Glu  His Ser Gly Arg Tyr  Arg Ala Ser Val Glu  Ser Ile Leu 
    2045                 2050                 2055             


Ile Phe  Asn Ser Met Asn Gln  Leu Asn Ser Leu Leu  Gln Lys Glu 
    2060                 2065                 2070             


Asn Leu  Gln Asp Val Phe Arg  Lys Val Glu Met Pro  Ser Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Ala Leu Leu Glu Leu  Asn Gly Ile Gly Phe  Ser Thr Ala 
    2090                 2095                 2100             


Glu Cys  Glu Ser Gln Lys His  Ile Met Gln Ala Lys  Leu Asp Ala 
    2105                 2110                 2115             


Ile Glu  Thr Gln Ala Tyr Gln  Leu Ala Gly His Ser  Phe Ser Phe 
    2120                 2125                 2130             


Thr Ser  Ser Asp Asp Ile Ala  Glu Val Leu Phe Leu  Glu Leu Lys 
    2135                 2140                 2145             


Leu Pro  Pro Asn Arg Glu Met  Lys Asn Gln Gly Ser  Lys Lys Thr 
    2150                 2155                 2160             


Leu Gly  Ser Thr Arg Arg Gly  Ile Asp Asn Gly Arg  Lys Leu Arg 
    2165                 2170                 2175             


Leu Gly  Arg Gln Phe Ser Thr  Ser Lys Asp Val Leu  Asn Lys Leu 
    2180                 2185                 2190             


Lys Ala  Leu His Pro Leu Pro  Gly Leu Ile Leu Glu  Trp Arg Arg 
    2195                 2200                 2205             


Ile Thr  Asn Ala Ile Thr Lys  Val Val Phe Pro Leu  Gln Arg Glu 
    2210                 2215                 2220             


Lys Arg  Leu Asn Pro Phe Leu  Gly Met Glu Arg Ile  Tyr Pro Val 
    2225                 2230                 2235             


Ser Gln  Ser His Thr Ala Thr  Gly Arg Ile Thr Phe  Ile Glu Pro 
    2240                 2245                 2250             


Asn Ile  Gln Asn Val Pro Arg  Asp Phe Glu Ile Lys  Met Pro Thr 
    2255                 2260                 2265             


Leu Val  Gly Glu Ser Pro Pro  Ser Gln Ala Val Gly  Lys Gly Leu 
    2270                 2275                 2280             


Leu Pro  Met Gly Arg Gly Lys  Tyr Lys Lys Gly Phe  Ser Val Asn 
    2285                 2290                 2295             


Pro Arg  Cys Gln Ala Gln Met  Glu Glu Arg Ala Ala  Asp Arg Gly 
    2300                 2305                 2310             


Met Pro  Phe Ser Ile Ser Met  Arg His Ala Phe Val  Pro Phe Pro 
    2315                 2320                 2325             


Gly Gly  Ser Ile Leu Ala Ala  Asp Tyr Ser Gln Leu  Glu Leu Arg 
    2330                 2335                 2340             


Ile Leu  Ala His Leu Ser His  Asp Arg Arg Leu Ile  Gln Val Leu 
    2345                 2350                 2355             


Asn Thr  Gly Ala Asp Val Phe  Arg Ser Ile Ala Ala  Glu Trp Lys 
    2360                 2365                 2370             


Met Ile  Glu Pro Glu Ser Val  Gly Asp Asp Leu Arg  Gln Gln Ala 
    2375                 2380                 2385             


Lys Gln  Ile Cys Tyr Gly Ile  Ile Tyr Gly Met Gly  Ala Lys Ser 
    2390                 2395                 2400             


Leu Gly  Glu Gln Met Gly Ile  Lys Glu Asn Asp Ala  Ala Cys Tyr 
    2405                 2410                 2415             


Ile Asp  Ser Phe Lys Ser Arg  Tyr Thr Gly Ile Asn  Gln Phe Met 
    2420                 2425                 2430             


Thr Glu  Thr Val Lys Asn Cys  Lys Arg Asp Gly Phe  Val Gln Thr 
    2435                 2440                 2445             


Ile Leu  Gly Arg Arg Arg Tyr  Leu Pro Gly Ile Lys  Asp Asn Asn 
    2450                 2455                 2460             


Pro Tyr  Arg Lys Ala His Ala  Glu Arg Gln Ala Ile  Asn Thr Ile 
    2465                 2470                 2475             


Val Gln  Gly Ser Ala Ala Asp  Ile Val Lys Ile Ala  Thr Val Asn 
    2480                 2485                 2490             


Ile Gln  Lys Gln Leu Glu Thr  Phe His Ser Thr Phe  Lys Ser His 
    2495                 2500                 2505             


Gly His  Arg Glu Gly Met Leu  Gln Ser Asp Arg Thr  Gly Leu Ser 
    2510                 2515                 2520             


Arg Lys  Arg Lys Leu Gln Gly  Met Phe Cys Pro Ile  Arg Gly Gly 
    2525                 2530                 2535             


Phe Phe  Ile Leu Gln Leu His  Asp Glu Leu Leu Tyr  Glu Val Ala 
    2540                 2545                 2550             


Glu Glu  Asp Val Val Gln Val  Ala Gln Ile Val Lys  Asn Glu Met 
    2555                 2560                 2565             


Glu Ser  Ala Val Lys Leu Ser  Val Lys Leu Lys Val  Lys Val Lys 
    2570                 2575                 2580             


Ile Gly  Ala Ser Trp Gly Glu  Leu Lys Asp Phe Asp  Val 
    2585                 2590                 2595     


<210>  16
<211>  2665
<212>  PRT
<213>  F. heteroclitus

<400>  16

Met Arg Pro Trp Gln Gln Pro Arg Asp Pro Gly Val Cys His Val Gly 
1               5                   10                  15      


Glu Glu Asn Ala Arg Met Ala Ser Gly Pro Leu Lys Lys Lys Ser Tyr 
            20                  25                  30          


Leu Gly Gln His Gln Ile Lys Lys Lys Thr Ser Ile Pro Ala Gly Asp 
        35                  40                  45              


His Glu Pro Thr Asp Gly Asp Gly Leu Leu Gln Lys Pro Ser Asp Lys 
    50                  55                  60                  


Thr Asn Arg Ala Gln Ser Ser Gly Arg Asp Gly Leu Met Gly Gly Arg 
65                  70                  75                  80  


Gly Ala Leu Leu Pro Leu Gly Glu Ser Thr Leu Ala Leu Asp Glu Glu 
                85                  90                  95      


Met Leu Gln Thr Leu Asp Ala Ala Asp Leu Ser Lys Gly Asp Val Lys 
            100                 105                 110         


Arg Asp Gly Lys Gly Ala Phe Pro Pro Pro Arg Pro Ala Pro Gln Thr 
        115                 120                 125             


Ala Arg Leu Lys Leu Asp Gly Lys Pro Ala Lys Val Asp Gly Glu Ser 
    130                 135                 140                 


Leu Pro Phe Thr Asn Gly Ala Glu Asp Pro Gln Gln Gly Gly Cys Lys 
145                 150                 155                 160 


Pro Arg Trp Asp Ser Asn Lys Pro Gly Trp Arg Ala Asp Cys Lys Asp 
                165                 170                 175     


Leu Ala Gln Lys Leu Leu Phe Ser Glu Asp Ser Gly Glu Ala Asp Arg 
            180                 185                 190         


Cys Thr Arg Asn Gln Glu Asn Asn Arg Ser Asp Asp Ala Pro Ala Ser 
        195                 200                 205             


Ala Ser Ala Leu Pro Cys Lys Glu Thr Arg Ser Arg Gln Lys Ala Gly 
    210                 215                 220                 


Gly Ser Arg Lys Gln Glu Leu Arg Gly Arg Gly Ser Pro Pro Ser Asp 
225                 230                 235                 240 


Gly Lys Asp Lys Ser Met Lys Asn Thr Asp Pro Pro Leu Asp Val Ser 
                245                 250                 255     


Thr Asp Tyr Ile Leu Phe Ser Pro Thr Arg Leu Ala Glu Ala Arg Arg 
            260                 265                 270         


Arg Ala Lys Leu Gln Gln Ser Leu His Asn Gln Ser Val Ser Val Leu 
        275                 280                 285             


Thr Val Pro Ser Gly Leu Glu Leu Ser Thr Leu Ser Asp Thr Leu Pro 
    290                 295                 300                 


Pro Pro Gly Val Ala Val Arg Ala Pro Glu Arg Gln Ala Glu Lys Leu 
305                 310                 315                 320 


Leu Leu Ser Ser Trp Gly Leu Pro Lys Pro Val Leu Glu Arg Tyr Gln 
                325                 330                 335     


Asn His Gly Val Thr Arg Met Phe Glu Trp Gln Ala Gln Cys Leu Ala 
            340                 345                 350         


Val Gly Gln Ala Leu Arg Gly Gly Asn Leu Val Tyr Ser Ala Pro Thr 
        355                 360                 365             


Ser Ala Gly Lys Thr Leu Val Ser Glu Leu Leu Ile Leu Lys Arg Val 
    370                 375                 380                 


Leu Glu Thr Arg Arg Lys Ala Leu Phe Ile Leu Pro Phe Val Ser Val 
385                 390                 395                 400 


Ala Lys Glu Lys Met His Tyr Leu Gln Ser Val Phe Glu Glu Ala Gly 
                405                 410                 415     


Ile Arg Val Glu Gly Tyr Met Gly Ser Thr Ser Ala Ala Gly Gly Phe 
            420                 425                 430         


Thr Thr Leu Asp Val Ala Val Cys Thr Ile Glu Lys Ala Asn Ser Leu 
        435                 440                 445             


Ile Asn Arg Leu Ile Glu Glu Asn Ser Met Asp Leu Leu Gly Val Val 
    450                 455                 460                 


Val Val Asp Glu Leu His Met Val Gly Asp Ser Gly Arg Gly Tyr Leu 
465                 470                 475                 480 


Leu Glu Leu Leu Leu Thr Lys Ile Arg Tyr Ile Ala Gln Lys Gln Asn 
                485                 490                 495     


Thr Ser Gly Ser Leu Ala Glu Gly Val Gln Ile Ile Gly Met Ser Ala 
            500                 505                 510         


Thr Leu Pro Asn Leu Ser Leu Leu Ala Gly Trp Leu Gly Ala Asp Leu 
        515                 520                 525             


Tyr Gln Thr Asp Tyr Arg Pro Val Pro Leu Gln Glu His Leu Lys Val 
    530                 535                 540                 


Gly Gly Asn Ile Tyr Asp Arg Ser Leu Ser Val Val Arg Gln Phe Thr 
545                 550                 555                 560 


Pro Ala Leu Asn Val Lys Gly Asp Asp Asp His Ile Val Ser Leu Cys 
                565                 570                 575     


Tyr Glu Thr Val Arg Glu Gly His Ser Val Leu Leu Phe Cys Pro Ser 
            580                 585                 590         


Lys Asn Trp Cys Glu Lys Leu Ala Asp Thr Ile Ala Arg Ala Phe Phe 
        595                 600                 605             


Asn Leu Arg Asn Thr Asp Pro Gln Ser Glu Gly Val Pro Pro Pro Val 
    610                 615                 620                 


Cys Leu Asp Thr Ala Gly Leu Val Asp Val Ile Ala Gln Leu Arg Arg 
625                 630                 635                 640 


Thr Pro Ala Gly Leu Asp Pro Ile Leu Gln Arg Thr Val Pro Trp Gly 
                645                 650                 655     


Val Gly Phe His His Ala Gly Leu Thr Phe Asp Glu Arg Asp Val Leu 
            660                 665                 670         


Glu Gly Ala Phe Arg Gln Gly Leu Val Arg Val Leu Ala Ala Thr Ser 
        675                 680                 685             


Thr Leu Ser Ser Gly Val Asn Leu Pro Ala Arg Arg Val Val Ile Arg 
    690                 695                 700                 


Thr Pro Val Phe Asn Gly Arg Leu Leu Asp Pro Leu Thr Tyr Lys Gln 
705                 710                 715                 720 


Met Ala Gly Arg Ala Gly Arg Lys Gly Val Asp Thr Thr Gly Glu Ser 
                725                 730                 735     


Val Leu Val Cys Lys Gln Ser Glu His Gln Lys Gly Ile Ser Leu Leu 
            740                 745                 750         


Gln Gly Ala Leu Gln Pro Ile Ser Ser Cys Leu Val Arg Arg Glu Gly 
        755                 760                 765             


Glu Gly Val Thr Thr Ser Met Leu Arg Ala Ile Leu Glu Val Ile Val 
    770                 775                 780                 


Gly Gly Val Ala Ser Ser Pro Arg Asp Val Arg Leu Tyr Ala Ser Cys 
785                 790                 795                 800 


Ser Leu Leu Ala Ala Ser Thr Lys Gly Asp Gly Gly Lys Glu Ser Thr 
                805                 810                 815     


Glu Glu Thr Ser Ser Gly Ala Ile Glu Ala Cys Val Asp Trp Leu Met 
            820                 825                 830         


Gly Asn Glu Phe Ile Ser Ile Gln Arg Asp Gly Gln Asp Glu Gln Tyr 
        835                 840                 845             


Cys Pro Thr Gln Leu Gly Ala Ala Thr Leu Ser Ser Ser Leu Ser Pro 
    850                 855                 860                 


Pro Glu Ala Leu Gly Ile Phe Ala Asp Leu Gln Arg Ala Met Lys Gly 
865                 870                 875                 880 


Phe Val Leu Glu Ser Asp Leu His Ile Leu Tyr Leu Ile Thr Pro Leu 
                885                 890                 895     


Tyr Ala Glu Trp Thr Thr Ile Asp Trp Tyr Gln Phe Phe Cys Leu Trp 
            900                 905                 910         


Glu Gln Leu Pro Ser Ser Met Lys Arg Val Ala Glu Leu Val Gly Val 
        915                 920                 925             


Gln Glu Gly Phe Leu Ala Arg Ser Val Ser Gly Lys Ile Val Ala Lys 
    930                 935                 940                 


Thr Glu Lys Gln Leu Arg Gln Met Ala Val His Lys Arg Phe Phe Thr 
945                 950                 955                 960 


Thr Leu Val Leu Gln Asp Leu Val Ser Glu Val Pro Leu Gly Ala Val 
                965                 970                 975     


Ala Ser Lys Tyr Asn Cys Asn Arg Gly Gln Leu Gln Ser Leu Gln Gln 
            980                 985                 990         


Ser Ala Ser Thr Tyr Ala Gly Met  Val Thr Val Phe Cys  Lys Arg Leu 
        995                 1000                 1005             


Gly Trp  His Asn Met Glu Leu  Leu Leu Ser Gln Tyr  Gln Thr Arg 
    1010                 1015                 1020             


Leu Ser  Phe Gly Val Gln Arg  Glu Leu Val Asp Leu  Val Arg Leu 
    1025                 1030                 1035             


Ser Leu  Leu Asn Ala Thr Arg  Ala Arg Ala Leu Tyr  Ala Gln Gly 
    1040                 1045                 1050             


Leu Cys  Thr Val Ala Gln Val  Ala Arg Ala Pro Val  Ala Asp Val 
    1055                 1060                 1065             


Glu Lys  Ala Leu Arg Asn Ala  Val Pro Phe Lys Ser  Ser Lys Arg 
    1070                 1075                 1080             


Ala Val  Asp Glu Ser Glu Met  Glu Ala Ala Glu Arg  Arg Asn Leu 
    1085                 1090                 1095             


Arg Cys  Val Trp Val Thr Gly  Gly Arg Ala Leu Thr  Glu Gln Glu 
    1100                 1105                 1110             


Ala Ala  Ala Glu Ile Val Ser  Glu Ala Arg Leu Leu  Leu Gln Glu 
    1115                 1120                 1125             


Asp Leu  Ala Gln Leu Gly Val  His Trp Asp Pro Ser  Thr Leu Pro 
    1130                 1135                 1140             


Pro Gln  Ala Pro Ser Gly Ser  Ser Ser Asp Asp Ser  His Ser Gly 
    1145                 1150                 1155             


Asp Ser  Asp Ala Ala Ser Ala  Pro Arg Val Ala Pro  Arg Arg Ser 
    1160                 1165                 1170             


Pro Met  Arg Arg Thr Glu Gly  His Pro Ser Gly Thr  His Thr Gly 
    1175                 1180                 1185             


Arg Arg  Asn Val Ser Lys Ser  Arg Gly Glu Glu Ile  Gly Arg Asp 
    1190                 1195                 1200             


Ala Glu  Ile Gln Glu Lys Val  Ala Tyr Gly Lys Gly  Ala Leu Glu 
    1205                 1210                 1215             


Gly Glu  Ala Arg Lys Pro Asp  Val Thr Asp Pro Glu  Ile Ser Asp 
    1220                 1225                 1230             


Val Leu  Val Glu Arg Ala Glu  Gly Arg Asn Glu Ala  Lys Pro Ser 
    1235                 1240                 1245             


Thr Ser  Arg Gln Asp Glu Ala  Glu His Val Glu Asp  Lys Gln Glu 
    1250                 1255                 1260             


Thr Ala  Gly Ala Val Gln His  Gly Gly Arg Leu Glu  Ser Ile Ser 
    1265                 1270                 1275             


Leu Val  Glu Glu Asp Arg Arg  Lys Arg Asn Lys Ser  Val Glu Glu 
    1280                 1285                 1290             


Gln Thr  His His Tyr Leu Asn  Gln Pro Ala Val Glu  Met Ser Leu 
    1295                 1300                 1305             


Thr Gln  Glu Leu Ala Glu Ile  Val Ser Ser Pro Leu  Pro Pro Pro 
    1310                 1315                 1320             


Pro Pro  Gln Pro Gln Pro Pro  Pro Ser Pro Ala Pro  Pro Pro Arg 
    1325                 1330                 1335             


Phe Arg  Ala Pro Val Ser Arg  Leu Ala His Arg Pro  Ser Ala Pro 
    1340                 1345                 1350             


Thr Ser  Thr Gly Lys Gly Gly  Cys Ser Thr Ser Pro  Leu Leu Pro 
    1355                 1360                 1365             


Arg Thr  Pro Lys His Ser Ala  Ala Leu Arg Lys Val  Leu Gln Ser 
    1370                 1375                 1380             


Ile Gln  Thr Gly Arg Gly Val  Gln Asp Arg Leu Gln  Pro Ala Asp 
    1385                 1390                 1395             


Leu Ser  Pro Ser Lys Val Pro  Asn Ala Ala Pro Val  Thr Leu Gln 
    1400                 1405                 1410             


Glu Asn  Pro Asp Val Ala Ser  Thr Pro Pro Gly Ala  Asp Ser Ala 
    1415                 1420                 1425             


Pro Leu  Phe Thr Pro Glu Ala  Lys Arg Arg Arg Thr  Glu Ala Gly 
    1430                 1435                 1440             


Gly Val  Asp Arg Phe Ser Ser  Pro Glu Leu Tyr Ala  Gly Ser Lys 
    1445                 1450                 1455             


Thr Asp  Glu Glu Glu Gln Gly  Asp Ala Glu Glu Glu  Glu Glu Glu 
    1460                 1465                 1470             


Glu Ser  Phe Gly Arg Ser Leu  Asp Leu Asp Thr Gln  Thr Glu Arg 
    1475                 1480                 1485             


Met Ile  Ala Gln Arg Pro Leu  Thr Gly Thr Ala Gly  Gly Arg Asp 
    1490                 1495                 1500             


Glu Ala  Gly Glu Gln Gln Gly  Glu Arg Arg Gly Asp  Arg Val Lys 
    1505                 1510                 1515             


Gly Pro  Asp Asp Asp Arg Arg  Asp Glu Ala Glu Gly  Pro Glu Thr 
    1520                 1525                 1530             


Ala Ala  Ala Arg Phe Gln Ile  Ser Val Thr Glu Ser  Gln Met Glu 
    1535                 1540                 1545             


Leu Ile  Leu Asn Ser Asn Pro  Arg Ala Ser Pro Ser  Pro Ala Arg 
    1550                 1555                 1560             


Gly Asp  Thr Asp Gln Ala Gly  Asp Asp Arg Gln Leu  Ser Asp Asn 
    1565                 1570                 1575             


Asn Glu  Ala Ala Ala Glu Ser  Pro Asp Gly Ser Ser  Gly Phe Leu 
    1580                 1585                 1590             


Phe Asp  Ser Met His Asp Ser  Ala Leu Leu Asp Thr  Leu Leu Leu 
    1595                 1600                 1605             


Asn Pro  Ser Pro Glu Pro Ala  Gly Glu Glu Glu Glu  Pro Ala Gly 
    1610                 1615                 1620             


Pro Ala  Pro Ala Pro Ser Ala  Gln Gln Lys Arg Arg  Ser Glu Leu 
    1625                 1630                 1635             


Leu Ala  Asn Gln Glu Ala Glu  Glu Gln Glu Ala Val  Arg Trp Gly 
    1640                 1645                 1650             


Glu Ser  Phe Phe Cys Leu Ser  Glu Trp Gly Glu Ser  Phe Leu Val 
    1655                 1660                 1665             


Gly Glu  Ala Phe Leu Gly Arg  Gln Ala Leu Ser Arg  His Ala Glu 
    1670                 1675                 1680             


Gly Gly  Glu Gly Asn Gln Gly  Leu Gln Gln Pro Ser  Lys Glu Glu 
    1685                 1690                 1695             


Glu Ser  Glu Glu Glu Lys Ala  Gly Gly Arg Gln Arg  Asp Glu Glu 
    1700                 1705                 1710             


Lys Asp  Ala Lys His Val Glu  Lys Leu Thr Gly Glu  Glu Arg Glu 
    1715                 1720                 1725             


Asn Leu  Ile Glu Asn Asp Val  Leu Lys Thr Pro Gly  Val Gln Asn 
    1730                 1735                 1740             


Ser Pro  Glu Ser Ala Phe Tyr  Cys Ser Pro Gly Leu  Gln Glu Ile 
    1745                 1750                 1755             


Phe Asp  Arg Trp Pro Ser Met  Ser Asp Gln Pro Gly  Pro Thr Ala 
    1760                 1765                 1770             


Asp Thr  Ala Asp Ala Thr Glu  Leu Pro Arg Pro Ala  Thr Gln Pro 
    1775                 1780                 1785             


Gly Arg  Lys Arg Lys Gln Pro  Gln Arg Pro Asp Ala  Thr Gln Lys 
    1790                 1795                 1800             


Ala Gln  Pro Pro Glu Arg Pro  Gly Ser Ala Gly Asp  Leu Ile Pro 
    1805                 1810                 1815             


Pro Thr  Gln Glu Thr Ala Pro  Val Thr Pro Arg Val  Lys Leu Thr 
    1820                 1825                 1830             


Thr Ser  Ser Val Leu Ser Pro  Ala Val Thr Gln Pro  Leu Lys Gln 
    1835                 1840                 1845             


Ser Thr  Pro Ser His Arg Leu  Gln Glu Gly Pro Thr  Asp Gly Glu 
    1850                 1855                 1860             


Arg Ala  Thr Ala His Ala Ala  Val Ser Val Ser Asp  Arg Arg Pro 
    1865                 1870                 1875             


Gln Arg  Ser Pro Pro Thr Gly  Arg Ser Leu Phe Phe  Pro Pro Gln 
    1880                 1885                 1890             


Thr Ala  Ala Ser Pro Pro Ser  Pro Arg Pro Glu Pro  Pro Ser Asp 
    1895                 1900                 1905             


Ala Glu  Ser Pro Val Ser Pro  Gly Gly Phe Ala Leu  Gln Leu Ser 
    1910                 1915                 1920             


Gln Asp  Ala Ser Leu Leu Cys  Ser Asp Ser Gly Ser  Phe Ser Ile 
    1925                 1930                 1935             


Ile Asp  Val Ala Ser Asp Arg  Arg Leu Phe Asp Thr  Phe Ile Lys 
    1940                 1945                 1950             


Glu Trp  Glu Thr Lys Glu Arg  Phe Ser Val Ala Leu  Ala Cys Glu 
    1955                 1960                 1965             


Arg Arg  Ala His Arg Arg Arg  Pro Glu Asp Asp Thr  Gly Gly Arg 
    1970                 1975                 1980             


Arg Lys  Arg Ala Ser Ala Ala  His Pro Thr Pro Asp  Gly Phe Pro 
    1985                 1990                 1995             


Val Gly  Asp Asp Glu Gly Arg  Thr Leu Ile Gly Leu  Ser Val Cys 
    2000                 2005                 2010             


Trp Gly  Ala Arg Asp Ala Tyr  Tyr Val Ser Leu Gln  Gln Glu Gln 
    2015                 2020                 2025             


Ser Glu  Gly Leu Ser Ser Ser  Leu Ala Pro Pro Pro  Leu Asp Lys 
    2030                 2035                 2040             


Ala Leu  Pro Val Thr Gln Arg  Leu Gln Arg Val Lys  Ala Cys Leu 
    2045                 2050                 2055             


Ser Ala  Ala Pro Ser Gly Arg  Arg Gly Arg Ala Val  Val Val Tyr 
    2060                 2065                 2070             


Asp Ile  Ile Lys Val Tyr Lys  Arg Leu Val Arg Ser  Cys Gly Ile 
    2075                 2080                 2085             


Ser Leu  Glu Gly Asn Tyr Glu  Asp Pro Lys Val Ala  Cys Trp Leu 
    2090                 2095                 2100             


Leu Asp  Pro Gly Arg Glu Glu  Arg Thr Leu Pro Asn  Met Val Thr 
    2105                 2110                 2115             


Val Tyr  Cys Pro Glu Glu Leu  Pro Leu Val Asp Gly  Leu Gly Asn 
    2120                 2125                 2130             


Ala His  Ser His Cys Pro Arg  Val Arg Ala Ala Thr  Glu Ser Val 
    2135                 2140                 2145             


Leu Val  His Ala Val Met Gln  His Leu Ser Gly Leu  Leu Glu Arg 
    2150                 2155                 2160             


Asp Gly  Ala Leu Asp Val Phe  Arg Arg Thr Glu Met  Pro Ser Gln 
    2165                 2170                 2175             


Val Cys  Leu Ala Leu Leu Glu  Leu Asn Gly Val Gly  Phe Ser Ala 
    2180                 2185                 2190             


Glu Glu  Cys Glu Arg Gln Lys  His Val Met Gln Ala  Lys Leu Ser 
    2195                 2200                 2205             


Ala Leu  Glu Ala Glu Ala Tyr  Ser Leu Ala Gly His  Ser Phe Ser 
    2210                 2215                 2220             


Leu Thr  Ser Val Asp Asp Val  Ala Gln Val Leu Phe  Leu Glu Leu 
    2225                 2230                 2235             


His Leu  Pro Pro Asn Gly Asp  Val Asp Gly Pro Arg  Ser Lys Lys 
    2240                 2245                 2250             


Thr Leu  Gly Tyr Thr Arg Arg  Gly Gly Gly Arg Ala  Arg Leu Gly 
    2255                 2260                 2265             


Lys Gln  Phe Ser Thr Thr Lys  Asp Val Leu Glu Lys  Leu Arg Pro 
    2270                 2275                 2280             


Leu His  Pro Leu Pro Gly Val  Ile Leu Glu Trp Arg  Arg Ile Thr 
    2285                 2290                 2295             


Asn Ala  Leu Thr Lys Val Val  Phe Pro Leu Gln Arg  Glu Lys Arg 
    2300                 2305                 2310             


Tyr Glu  Pro Thr Leu Asp Met  Asp Arg Ile Tyr Pro  Val Ala Gln 
    2315                 2320                 2325             


Thr His  Thr Ala Thr Gly Arg  Val Ser Phe Thr Glu  Pro Asn Ile 
    2330                 2335                 2340             


Gln Asn  Val Pro Lys Asp Phe  Glu Ile Ser Leu Pro  Thr Val Val 
    2345                 2350                 2355             


Gly Glu  Ser Pro Pro Ser Gln  Gly Gly Phe Gln Met  Pro Asn Arg 
    2360                 2365                 2370             


Pro Gly  Arg Arg Arg Ser Val  Ala Pro Leu Pro Ala  Ala Ala Asp 
    2375                 2380                 2385             


Gln Gly  Pro Ala Phe Ser Val  Ser Met Arg His Ala  Phe Val Pro 
    2390                 2395                 2400             


Phe Ser  Gly Gly Met Ile Leu  Ala Ala Asp Tyr Ser  Gln Leu Glu 
    2405                 2410                 2415             


Leu Arg  Val Leu Ala His Leu  Ser Lys Asp Gln Arg  Leu Leu Gln 
    2420                 2425                 2430             


Val Leu  Asn Gly Gly Ala Asp  Val Phe Arg Cys Ile  Ala Ala Glu 
    2435                 2440                 2445             


Trp Lys  Ser Val Glu Pro Ala  Ser Val Gln Asp Asp  Leu Arg Gln 
    2450                 2455                 2460             


Gln Ala  Lys Gln Ile Cys Tyr  Gly Ile Ile Tyr Gly  Met Gly Ala 
    2465                 2470                 2475             


Lys Ser  Leu Gly Glu Gln Met  Gly Val Glu Glu Asn  Asp Ala Ala 
    2480                 2485                 2490             


Cys Tyr  Ile Glu Ser Phe Lys  Ala Arg Tyr Lys Gly  Ile Asn Ala 
    2495                 2500                 2505             


Phe Leu  Lys Gln Thr Val Lys  Lys Cys Leu Lys Asp  Gly Tyr Val 
    2510                 2515                 2520             


Gln Thr  Leu Met Gly Arg Arg  Arg Tyr Leu Ala Gly  Ile Ala Asn 
    2525                 2530                 2535             


Ala Asn  Pro His Val Lys Ala  His Ala Glu Arg Gln  Ala Val Asn 
    2540                 2545                 2550             


Thr Thr  Val Gln Gly Ser Ala  Ala Asp Ile Val Lys  Leu Ala Thr 
    2555                 2560                 2565             


Val Asn  Ile Gln Lys Arg Leu  Arg Glu Thr Tyr Pro  Ser Ala Pro 
    2570                 2575                 2580             


Leu Ser  His Gln His Ala His  Ser Ala His Asn Asn  Gln Arg Arg 
    2585                 2590                 2595             


Phe Gly  Thr Ser Arg Leu Arg  Gly Ala Tyr Phe Ile  Leu Gln Leu 
    2600                 2605                 2610             


His Asp  Glu Leu Ile Tyr Glu  Thr Thr Glu Arg Asp  Leu Ile Gln 
    2615                 2620                 2625             


Val Ala  Gln Ile Val Lys Arg  Glu Met Glu Ser Ala  Val Lys Leu 
    2630                 2635                 2640             


Tyr Val  Lys Leu Lys Ala Lys  Val Lys Val Gly Pro  Ser Trp Gly 
    2645                 2650                 2655             


Asn Leu  Gln Asp Leu Asp Ile  
    2660                 2665 


<210>  17
<211>  2674
<212>  PRT
<213>  C. gigas

<400>  17

Met Thr Ser Lys Ser Lys Asn Gly Gly Met Glu Leu Asp Ala Ser Phe 
1               5                   10                  15      


Ser Ser Ser Phe Cys Thr Glu Leu Asp Ala Gln Met Leu Val Ala Met 
            20                  25                  30          


Glu Thr Met Glu Lys Gln Pro Arg Ser Gln Lys Ser Leu Pro Lys Gly 
        35                  40                  45              


Thr Lys Lys Asn Ser Pro Val Leu Thr Ser Thr Pro Gln Ser Val Thr 
    50                  55                  60                  


Pro Leu Pro Arg Arg Gln Ala Gln Leu Met Lys Ser Leu Phe Thr Leu 
65                  70                  75                  80  


Gln Ser Pro Leu Asn Asp Ser Leu Phe Ser Pro Phe Ser Ser Gln Thr 
                85                  90                  95      


Thr Asp Asn Val Lys Asp Gly Glu Gln Leu Thr Pro Ser Ser Ala Met 
            100                 105                 110         


Asn Gly Lys Pro Cys Arg Lys Arg Thr Arg Lys Val Leu Asn Glu Ile 
        115                 120                 125             


Ile Asn Glu Lys Glu Arg Ile Asp Glu Asp Asn Gly Asp Lys Leu Leu 
    130                 135                 140                 


Leu Lys Asn Trp Gly Leu Pro Glu Pro Val Met Lys Gln Tyr Ser Asp 
145                 150                 155                 160 


Lys Gly Ile Thr Ser Met Phe Glu Trp Gln Ala Glu Cys Leu Cys Leu 
                165                 170                 175     


Pro Gly Val Leu Asp Gly Gly Asn Leu Val Tyr Ser Ala Pro Thr Ser 
            180                 185                 190         


Ala Gly Lys Thr Met Val Ala Glu Leu Leu Val Leu Lys Arg Val Leu 
        195                 200                 205             


Glu Thr Lys Lys Lys Ala Ile Ile Ile Leu Pro Phe Val Ser Val Ala 
    210                 215                 220                 


Arg Glu Lys Met Phe Tyr Leu Gln Gln Leu Tyr Gln Glu Val Gly Val 
225                 230                 235                 240 


Ser Val Ser Gly Phe Met Gly Ser Tyr Ser Pro Pro Gly Gly Leu Ser 
                245                 250                 255     


Gln Val Asp Val Ala Val Cys Thr Ile Glu Lys Gly Asn Gly Leu Ile 
            260                 265                 270         


Asn Arg Leu Met Glu Glu Asn Arg Leu Asp Gln Leu Gly Ile Val Val 
        275                 280                 285             


Ile Asp Glu Leu His Leu Val Gly Asp Gln His Arg Gly Tyr Leu Leu 
    290                 295                 300                 


Glu Leu Met Leu Thr Lys Ile Arg Phe Leu Ser Gln Arg Met Lys Lys 
305                 310                 315                 320 


Pro Asp Pro Gln Asn Met Glu Ser Ser Ser Thr Glu Gly Ile Gln Ile 
                325                 330                 335     


Ile Gly Met Ser Ala Thr Leu Pro Asn Leu Asp Leu Leu Ala Arg Trp 
            340                 345                 350         


Leu Asp Ala Thr Leu Tyr Arg Thr Asp Tyr Arg Pro Val Pro Leu Thr 
        355                 360                 365             


Glu Cys Val Lys Leu Gly Ala Asp Ile Phe Asp Ser Arg Leu Gln Lys 
    370                 375                 380                 


Ile Arg Glu Val Asp Leu Ser Val Thr Phe Lys Gly Asp Thr Asp His 
385                 390                 395                 400 


Val Val Pro Leu Cys Leu Glu Thr Leu Arg Asp Gly His Ser Val Leu 
                405                 410                 415     


Ile Phe Cys Pro Thr Lys Asn Trp Cys Glu Lys Leu Ala Glu Thr Ile 
            420                 425                 430         


Ala Arg Glu Phe Tyr Gly Ile Leu Lys Lys Ala Pro Val Asp Met Gln 
        435                 440                 445             


Ala Asn Gln Gly Ser Gly Gly Asn Pro Pro Ser Pro Cys Leu Pro Leu 
    450                 455                 460                 


Ser Arg Ala Ser Leu Gln Glu Val Val Glu Gln Leu Arg Arg Thr Pro 
465                 470                 475                 480 


Val Gly Leu Asp Ser Thr Leu Gly Lys Thr Val Pro Tyr Gly Val Ala 
                485                 490                 495     


Tyr His His Ala Gly Lys Tyr Gln His Lys Phe Ile Val Arg Val Lys 
            500                 505                 510         


Glu Asp Pro Gly Gly Ala Arg Leu Tyr Pro Glu Glu Asp Cys Pro Tyr 
        515                 520                 525             


Val Val Ala His His His Thr Gly Leu Thr Phe Asp Glu Arg Asp Ile 
    530                 535                 540                 


Leu Glu Gly Ala Phe Arg Gln Gly Ala Val Lys Val Leu Ile Ala Thr 
545                 550                 555                 560 


Ser Thr Leu Ser Ser Gly Val Asn Leu Pro Ala Arg Arg Val Ile Ile 
                565                 570                 575     


Arg Thr Pro Leu Phe His Gly Lys Thr Ile Asp Phe Leu Thr Tyr Lys 
            580                 585                 590         


Gln Met Ile Gly Arg Ala Gly Arg Lys Gly Val Asp Thr Gln Gly Glu 
        595                 600                 605             


Ser Ile Leu Ile Cys Lys Pro Gly Glu Arg Ser Lys Ala Val Thr Leu 
    610                 615                 620                 


Val Gln Ser Ala Leu Pro Pro Val Ser Ser Cys Leu Ile Lys Asn Gln 
625                 630                 635                 640 


Gly Glu Gln Leu Ser Ser Ser Met Lys Arg Ala Ile Leu Glu Ile Val 
                645                 650                 655     


Val Ser Gly Val Ala Asp Ser Val Thr Asp Val Thr Ala Tyr Ala Ser 
            660                 665                 670         


Cys Thr Met Leu Ala Ala Ser Leu Asp Thr Ser Ser Asp Gln Thr Gln 
        675                 680                 685             


Gly Met Ile Ser Ala Cys Ile Gln Phe Leu Gln Glu Asn Glu Phe Val 
    690                 695                 700                 


Ser Leu Gln Arg Val Gln Ser Ser Asp Gly Val Tyr Glu Asp Arg Phe 
705                 710                 715                 720 


Val Pro Thr Gln Leu Gly Ala Ala Val Leu Ala Ser Ser Leu Ser Pro 
                725                 730                 735     


Asp Glu Gly Leu Ser Val Phe Ala Glu Leu Gln Lys Ala Arg Gln Cys 
            740                 745                 750         


Phe Val Leu Glu Asn Glu Leu His Ile Val Tyr Leu Val Thr Pro Ile 
        755                 760                 765             


Tyr Ser Leu Asp Leu Gly Ala Gly Met Asn Trp Tyr Lys Phe Tyr Cys 
    770                 775                 780                 


Leu Trp Asp Lys Leu Ser Pro Asp Lys Lys Arg Val Ala Gln Leu Val 
785                 790                 795                 800 


Gly Val Ser Glu Ala Phe Leu Thr Arg Ala Ile Gln Gly Arg Ile Pro 
                805                 810                 815     


Thr Lys Thr Glu Asn Gln Ile Arg Ser Leu Ala Ile His Lys Arg Phe 
            820                 825                 830         


Tyr Thr Ser Leu Ile Leu Ser Asp Leu Val Gln Glu Val Pro Leu Gly 
        835                 840                 845             


Glu Val Cys His Arg Tyr Gly Ala Asn Lys Gly Gln Leu Gln Ser Leu 
    850                 855                 860                 


Gln Gln Thr Ala Ala Thr Phe Ala Gly Met Val Thr Val Phe Cys Ala 
865                 870                 875                 880 


Arg Leu Gly Trp Tyr Asn Leu Glu Leu Ile Leu Gly Gln Phe Gln His 
                885                 890                 895     


Arg Leu Thr Phe Gly Ile Gln Arg Glu Leu Cys Asp Leu Val Arg Leu 
            900                 905                 910         


Thr Leu Leu Asn Gly Gln Arg Ala Arg Val Leu Tyr Asp Gly Gly Phe 
        915                 920                 925             


His Thr Val Ala Ala Leu Ala Asn Ala Ser Val Ser Asp Val Glu Lys 
    930                 935                 940                 


Ile Phe Lys Lys Ser Ser Pro Phe Gln Ser Ser Lys Lys Leu Glu Asn 
945                 950                 955                 960 


Glu Thr Glu Trp Glu Ala Ala Arg Arg Gln Glu Ser Arg Cys Ile Trp 
                965                 970                 975     


Leu Thr Gly Arg Lys Gly Ala Thr Glu Arg Glu Ala Ala Gln Ala Ile 
            980                 985                 990         


Ile Gln Glu Ala Lys Ser Leu Ile  Gln Gln Glu Leu Gly  Gly Leu Gly 
        995                 1000                 1005             


Ile Gln  Trp Lys Thr Pro Asp  Thr Arg Lys Ser Leu  Glu Glu Gly 
    1010                 1015                 1020             


Ser Asn  Pro Asp Gln Asn Gly  Met Asp Cys Ser Arg  Asp Leu Glu 
    1025                 1030                 1035             


Lys Ser  Ser Asn Asn His Gln  Ile Gly Leu Met Lys  Met Lys Ser 
    1040                 1045                 1050             


Lys Gly  Ser Val Arg Lys Arg  Arg Ser Leu Ser Arg  Lys Ser Pro 
    1055                 1060                 1065             


Ala Leu  Ser Gln Ala Arg Ser  Ser Arg Gly Lys Gly  Phe Asn Arg 
    1070                 1075                 1080             


Gln Glu  Lys Ser Val Val Ile  Ser Pro Pro Ser Phe  Asn Ser Gln 
    1085                 1090                 1095             


Ser Arg  Arg Asn Lys Ser Asn  Ile Gly Thr Asp Ser  Gly Ser Gly 
    1100                 1105                 1110             


Lys Pro  Cys Asp Asn Asp Cys  Ile Val Ile Val Asp  Asp Ser Ser 
    1115                 1120                 1125             


Gly Asp  Pro Asn Glu Arg Gln  Gly Asn Lys Glu Ile  Pro Ser Ile 
    1130                 1135                 1140             


Lys Asp  Phe Val Val Arg Gln  Ile Glu Glu Gln Ser  Cys Gln Gln 
    1145                 1150                 1155             


Arg Asn  Arg Asn Asn Pro Glu  Lys Arg Asp Cys Glu  Lys Asn Cys 
    1160                 1165                 1170             


Thr Ser  Glu Val Arg Val Gln  Pro Asn His Met Tyr  His Lys Asp 
    1175                 1180                 1185             


Gln Leu  Gln Ile Asp Leu Val  Lys Thr Asn Ala Asn  Cys Asn Glu 
    1190                 1195                 1200             


Glu Ala  Gly Lys Gln Leu Thr  Gly Leu His Glu Ala  Arg Glu Lys 
    1205                 1210                 1215             


Pro Arg  Val Glu Ala Ile Lys  Ala Asn Pro Ser Arg  Cys Thr Glu 
    1220                 1225                 1230             


Arg Glu  Asn Val Ser Ala Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    1235                 1240                 1245             


Thr Ser  Ser Ser Val Ile Asn  Ser Ser Ser Arg Pro  Ala Glu Asp 
    1250                 1255                 1260             


Ser His  Val Phe Lys Ser Pro  Ile Phe Ser Ser Val  Ser Thr Gly 
    1265                 1270                 1275             


Ile Lys  Lys Ser Gly Pro Lys  Thr Arg Ser Ser Ser  Phe Pro Leu 
    1280                 1285                 1290             


Ser Thr  Leu Ser Thr Ser Ser  Thr Ser Leu Gly Ser  Ser Thr Ala 
    1295                 1300                 1305             


Ser Val  Val Met Ser Pro Gln  Leu Ala Lys Asn Lys  Asn Asp Leu 
    1310                 1315                 1320             


Ile Lys  Ile Pro Ser Asn Lys  Arg Asn Ala Met Pro  Asn Gln Ser 
    1325                 1330                 1335             


Ile Gln  Arg Gly Ile Leu Ser  Gly Val Gln Gln Ile  Ile Thr Asn 
    1340                 1345                 1350             


Ser Thr  Asp Leu Glu Thr Val  Asn Gly Lys Leu Asn  Glu His Glu 
    1355                 1360                 1365             


Ser Asp  Val Arg Thr Ile Asn  Glu Arg Arg Gln Lys  Ala Asp Leu 
    1370                 1375                 1380             


Thr Pro  Glu Ala Asn Phe Arg  Glu Leu Arg Asp Arg  Gly Asp Ser 
    1385                 1390                 1395             


Glu Glu  Arg Lys Lys Leu Gln  Glu Ile Lys Val Asn  Lys Thr Ile 
    1400                 1405                 1410             


Glu Pro  Met Ile Cys Ser Glu  Asp Phe Ala Asp Ser  Phe Val Phe 
    1415                 1420                 1425             


Glu Ser  Gln Met Asp Gly Asn  Met Glu Ala Phe Pro  Gly Leu Cys 
    1430                 1435                 1440             


Asn Glu  Val Ser Gln Ser Leu  Gln Ser Lys Lys Thr  Leu Gly Asp 
    1445                 1450                 1455             


Ser Glu  Lys Ile Asn Ser Lys  Ile Val Val Asp Lys  Ile Ile Glu 
    1460                 1465                 1470             


Lys Gln  Ile Asn Ser Asn Gly  Phe Phe Gln Pro Asn  Gly Ser Ser 
    1475                 1480                 1485             


Ser Ser  Lys Lys His Leu Val  Arg Asn Ala His Ile  Val Val Glu 
    1490                 1495                 1500             


Lys His  Arg Thr Asn Thr Ala  Leu Ser Thr Ala Asp  Ala Ala Thr 
    1505                 1510                 1515             


Val Asn  Lys Glu Gln Val Asp  Asp Glu His Ser Thr  Asp Gly Asn 
    1520                 1525                 1530             


Asp Met  Asn Leu Ser Cys Ser  Leu Leu Ser Ser His  Asp Val Ser 
    1535                 1540                 1545             


Cys Asp  Leu Leu Pro Ala Ser  Asn Phe Glu Lys Cys  Met Val Ser 
    1550                 1555                 1560             


Asp Asp  Glu Ser Asp Val Cys  Arg Asp Glu Ser Tyr  Arg Asp Leu 
    1565                 1570                 1575             


Arg Ile  Pro Tyr Leu Ser Gly  Gln Glu Ala Ala Cys  Phe Asp Gly 
    1580                 1585                 1590             


Asn Glu  Arg Lys Ala Asp Leu  Ala Leu Gly Gly Tyr  Gln Ile Ser 
    1595                 1600                 1605             


Gln Gly  Leu Leu Gln Glu Leu  Asp Glu Thr Phe Ser  Glu Glu Cys 
    1610                 1615                 1620             


Ser Gln  Gly Ser Lys Gly Gln  Ser Gln Arg Ser Ala  Gly Gln Gly 
    1625                 1630                 1635             


Gly Ser  Phe Lys Asn Gly Lys  Lys Gln Asn Asn Asn  Ser Ile Asp 
    1640                 1645                 1650             


Gly Met  Glu Ala Ser Lys Val  Glu Gln Gly Lys Ala  Thr Glu Gln 
    1655                 1660                 1665             


Asn Leu  Lys Thr Phe Glu Lys  Lys Lys Asn Gly Gln  Ile Ile Glu 
    1670                 1675                 1680             


Arg Lys  Met Glu Glu Ala Glu  Val Gly Val Thr Glu  Glu Met Asp 
    1685                 1690                 1695             


Asp Ser  Leu Thr Leu Ser Met  Val Tyr Glu Val Ile  Glu Asn Cys 
    1700                 1705                 1710             


Asp Lys  Gly Gln Cys Asn Lys  Asn Leu Asn Ser Lys  Thr Asp Lys 
    1715                 1720                 1725             


Ser Asn  Thr Asn Gln Leu Thr  Ser Arg Arg Ser Ser  Gln Arg Asn 
    1730                 1735                 1740             


Ala Lys  Ser Asn Ser Lys Lys  Thr Asn Glu Ile Ile  Cys Glu Glu 
    1745                 1750                 1755             


Leu Ile  Ser Lys Lys Ser Ser  Glu Cys Asn Lys Arg  Ser Thr Leu 
    1760                 1765                 1770             


Lys Ser  Lys Glu Ser Ser Phe  Thr Lys Val Lys Cys  Ser Arg Ser 
    1775                 1780                 1785             


Ser Gln  Asp Lys Asp Lys Arg  Leu Ser Pro Gly Thr  Leu Ala Phe 
    1790                 1795                 1800             


Leu Asp  Asp Leu His Thr Ser  Leu Asp Thr Asp Ser  Asp Thr Ile 
    1805                 1810                 1815             


Val Met  Lys Thr Pro Leu Cys  Gln Arg Arg Arg Gly  Asn Asn Asn 
    1820                 1825                 1830             


Lys Glu  Gly Ser Thr Arg Asp  Ser Val Val Met Asp  Glu Val Met 
    1835                 1840                 1845             


Asp Glu  Asp Leu Gln Asn Glu  Tyr Ser Gly Glu Asp  Asn Val Arg 
    1850                 1855                 1860             


Thr Asn  Glu Cys Leu Ser Pro  Thr Pro Pro Arg Leu  Ser Leu Val 
    1865                 1870                 1875             


Asn Ser  Pro Lys Thr Ile Arg  Lys Ala Thr Pro Asn  Arg His Arg 
    1880                 1885                 1890             


Pro Gln  Lys Gln Asp Asp Arg  Arg Ser Ala Arg Lys  Asn Ile Glu 
    1895                 1900                 1905             


Ser Leu  Gly Val Ser Met Lys  Asn Ser Lys Val Pro  Phe Val Glu 
    1910                 1915                 1920             


Ser Ala  Lys Ser Ala Glu Glu  Glu Val Arg Glu Trp  Asn Ser Gly 
    1925                 1930                 1935             


Lys Leu  Glu Ser Pro Thr Gly  Glu Asp Pro Pro Tyr  Val Glu Arg 
    1940                 1945                 1950             


Gly Pro  Val Val Asp Pro Asn  Glu Thr Gly Ile Pro  Pro Ser Gln 
    1955                 1960                 1965             


Gly Ala  Phe Thr Ile Ile Asp  Val Cys Ala Asp Lys  Val Leu Phe 
    1970                 1975                 1980             


Asp Thr  Phe Ile Lys Glu Trp  Asn Cys Gln Pro Ser  Phe Ala Ile 
    1985                 1990                 1995             


Ser Leu  Ala Cys Ile Asn Lys  Pro Arg Asp Pro Val  Thr Thr Thr 
    2000                 2005                 2010             


Gly Gly  Ile Gly Ala Lys Phe  Thr Glu Ala Gly Asp  Thr Gly His 
    2015                 2020                 2025             


Lys Ser  Ser Lys Val Lys Thr  Thr Glu Pro Gly Val  Ala Ser Arg 
    2030                 2035                 2040             


Gly Ile  Pro Val Trp Gly Val  Asn Leu Val Ile Thr  Gly Val Ala 
    2045                 2050                 2055             


Val Ser  Trp Gly Asp Arg Asp  Ala Tyr Phe Ile Thr  Leu Thr Ser 
    2060                 2065                 2070             


Glu Asn  Ile Glu Asp Glu Glu  Asp Thr Asp Leu Ser  Pro Pro Asp 
    2075                 2080                 2085             


Leu Asp  Lys Ser Leu Ser Val  Thr Ala Arg Leu Ala  Ala Ile Arg 
    2090                 2095                 2100             


Gln Val  Leu Glu Arg Lys Asp  Ser Phe Thr Val Ile  Ala Met Asp 
    2105                 2110                 2115             


Ala Lys  Ala Cys Tyr Gly Ala  Leu Glu Arg Ser Cys  Gly Ile Cys 
    2120                 2125                 2130             


Cys Gln  Gly Glu Phe Gln Asp  Pro Lys Val Ala Thr  Trp Leu Leu 
    2135                 2140                 2145             


Asp Pro  Gly Ala Lys Glu Lys  Asn Leu His Arg Met  Val His Asp 
    2150                 2155                 2160             


Tyr Leu  Pro Leu Glu Ala Phe  Leu Leu Glu Asp Ile  Gly Gly Gly 
    2165                 2170                 2175             


Val Gly  Tyr Gly Ser Ile Gly  Met Ser Pro Glu Asn  Pro Gly Ser 
    2180                 2185                 2190             


Ser Arg  Val Arg Ser Cys Thr  Glu Ala Val Leu Leu  Thr His Leu 
    2195                 2200                 2205             


Met Gln  Phe Tyr Thr Leu Cys  Phe Asn Asp Glu Glu  Cys Glu Arg 
    2210                 2215                 2220             


Gln Lys  Asn Ile Met Val Ala  Arg Leu Gly Asp Leu  Glu Glu Gln 
    2225                 2230                 2235             


Ala Tyr  Arg Cys Val Gly His  Gln Phe Ser Leu Thr  Ser Thr Glu 
    2240                 2245                 2250             


Asp Leu  Ser Gln Ile Leu Phe  Ile Glu Leu Gln Leu  Pro Val Asn 
    2255                 2260                 2265             


Gly Asp  Pro Ser Ser Leu Gly  Gln Pro Met Arg Pro  Asn Arg Arg 
    2270                 2275                 2280             


Ala Pro  Asn Ser His Arg Gly  Arg Gln Lys Ser Gln  Phe Ser Thr 
    2285                 2290                 2295             


Thr Lys  Glu Val Leu Glu Lys  Leu Arg Pro Leu His  Pro Phe Pro 
    2300                 2305                 2310             


Gly Ile  Leu Leu Glu Trp Arg  Arg Ile Ser Gly Ser  Leu Thr Lys 
    2315                 2320                 2325             


Val Val  Phe Ala Leu Gln Lys  Glu Lys Val Tyr Cys  Glu Asn Leu 
    2330                 2335                 2340             


Gly Met  His Arg Ile Phe Thr  Asp Val Gln Tyr Phe  Thr Ala Thr 
    2345                 2350                 2355             


Gly Arg  Val Ser Leu Ser Glu  Pro Asn Leu Gln Asn  Val Pro Lys 
    2360                 2365                 2370             


Asp Phe  Leu Ile Ser Val Ser  Ala Pro Val Glu Asn  Phe Asn Gln 
    2375                 2380                 2385             


Trp Asp  Ala Ala Gly His Arg  Asn Lys Asn Arg Asn  Ser Gly Gln 
    2390                 2395                 2400             


Thr Ser  Phe Asn Val Ser Met  Arg His Ala Phe Ile  Pro Phe Pro 
    2405                 2410                 2415             


Gly Gly  Val Leu Leu Ala Ala  Asp Tyr Ser Gln Leu  Glu Leu Arg 
    2420                 2425                 2430             


Met Ile  Ala His Leu Ser Gln  Asp Ser Lys Leu Ile  Lys Ile Leu 
    2435                 2440                 2445             


Asn Gly  Asp Gly Asp Val Phe  Lys Leu Ile Thr Ala  Gln Trp Lys 
    2450                 2455                 2460             


Ser Ile  Ser Val Glu Glu Val  Thr Pro Glu Gln Arg  Gln Gln Ala 
    2465                 2470                 2475             


Lys Gln  Ile Cys Tyr Gly Met  Ile Tyr Gly Ile Gly  Ala Lys Ala 
    2480                 2485                 2490             


Leu Gly  Asp Thr Leu Gly Val  Glu Glu Asn Asp Ala  Ala Ala Phe 
    2495                 2500                 2505             


Ile Gln  Thr Phe Lys Ser Lys  Tyr Pro Gly Met Arg  Arg Tyr Leu 
    2510                 2515                 2520             


Lys Asp  Thr Val Asp Lys Cys  Cys Lys Asn Gly Tyr  Val Glu Thr 
    2525                 2530                 2535             


Ile Ser  Gly Arg Arg Arg Tyr  Leu Pro Ser Ile Ser  Asn Lys Lys 
    2540                 2545                 2550             


Pro Tyr  Val Arg Ala His Ala  Glu Arg Gln Ala Val  Asn Thr Thr 
    2555                 2560                 2565             


Val Gln  Gly Ser Ala Ala Asp  Leu Val Lys Val Ala  Met Asn Arg 
    2570                 2575                 2580             


Ile Asp  Asp Arg Leu Ser Ala  Met Phe Pro Leu Ser  Lys Lys Thr 
    2585                 2590                 2595             


Phe Ser  Tyr Lys Glu Asp Glu  Val Gln Gly Ile Glu  Leu Ser Ser 
    2600                 2605                 2610             


Asp Arg  Cys Cys Leu Val Leu  Gln Leu His Asp Glu  Leu Ile Tyr 
    2615                 2620                 2625             


Glu Val  Thr Glu Arg Cys Leu  Gly Gln Ala Ala Lys  Val Ile Lys 
    2630                 2635                 2640             


Glu Glu  Met Glu Thr Ala Met  Thr Leu Ser Val Lys  Met Pro Val 
    2645                 2650                 2655             


Lys Val  Lys Ser Gly Leu Ser  Trp Ala Thr Met Gln  Asp Leu Ala 
    2660                 2665                 2670             


Val 
    


<210>  18
<211>  2544
<212>  PRT
<213>  M. musculus

<400>  18

Met Ser Leu Pro Arg Arg Ser Arg Lys Arg Arg Arg Ser Ser Ser Gly 
1               5                   10                  15      


Ser Asp Thr Phe Ser Gly Asp Gly Asp Ser Phe Val Ser Pro Gln Leu 
            20                  25                  30          


Arg Cys Gly Pro Val Leu Ser Pro Pro Pro Gly Leu Gly Arg Gly Arg 
        35                  40                  45              


Arg Leu Thr Gly Thr Gly Thr Asn Lys Arg Arg Val Ser Asp Asp Gln 
    50                  55                  60                  


Ile Asp Gln Leu Leu Leu Ala Asn Trp Gly Leu Pro Lys Ala Val Leu 
65                  70                  75                  80  


Glu Lys Tyr His Ser Phe Gly Val Arg Lys Met Phe Glu Trp Gln Ala 
                85                  90                  95      


Glu Cys Leu Leu Leu Gly His Val Leu Glu Gly Lys Asn Leu Val Tyr 
            100                 105                 110         


Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu Leu Ile 
        115                 120                 125             


Leu Lys Arg Val Leu Glu Thr Arg Lys Lys Ala Leu Phe Ile Leu Pro 
    130                 135                 140                 


Phe Val Ser Val Ala Lys Glu Lys Lys Cys Tyr Leu Gln Ser Leu Phe 
145                 150                 155                 160 


Gln Glu Val Gly Leu Lys Val Asp Gly Tyr Met Gly Ser Thr Ser Pro 
                165                 170                 175     


Thr Gly Gln Phe Ser Ser Leu Asp Ile Ala Val Cys Thr Ile Glu Arg 
            180                 185                 190         


Ala Asn Gly Leu Val Asn Arg Leu Ile Glu Glu Asn Lys Met Asp Leu 
        195                 200                 205             


Leu Gly Met Val Val Val Asp Glu Leu His Met Leu Gly Asp Ser His 
    210                 215                 220                 


Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Ile Cys Tyr Val Thr 
225                 230                 235                 240 


Arg Lys Ser Ala Ser His Gln Ala Glu Ser Ala Ser Thr Leu Ser Asn 
                245                 250                 255     


Ala Val Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu Gln Leu 
            260                 265                 270         


Val Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe Arg Pro 
        275                 280                 285             


Val Pro Leu Leu Glu Ser Ile Lys Ile Gly Asn Ser Ile Tyr Asp Ser 
    290                 295                 300                 


Ser Met Lys Leu Val Arg Glu Phe Gln Pro Leu Leu Gln Val Lys Gly 
305                 310                 315                 320 


Asp Glu Asp His Ile Val Ser Leu Cys Tyr Glu Thr Ile Gln Asp Asn 
                325                 330                 335     


His Ser Val Leu Ile Phe Cys Pro Ser Lys Lys Trp Cys Glu Lys Val 
            340                 345                 350         


Ala Asp Ile Ile Ala Arg Glu Phe Tyr Asn Leu His His Gln Pro Glu 
        355                 360                 365             


Gly Leu Val Lys Ser Ser Glu Phe Pro Pro Val Ile Leu Asp Gln Lys 
    370                 375                 380                 


Ser Leu Leu Glu Val Met Asp Gln Leu Lys Arg Ser Pro Ser Gly Leu 
385                 390                 395                 400 


Asp Ser Val Leu Lys Asn Thr Val Pro Trp Gly Val Ala Phe His His 
                405                 410                 415     


Ala Gly Leu Thr Phe Glu Glu Arg Asp Ile Ile Glu Gly Ala Phe Arg 
            420                 425                 430         


Gln Gly Phe Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser Gly 
        435                 440                 445             


Val Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Ile Phe Ser 
    450                 455                 460                 


Gly Gln Pro Leu Asp Ile Leu Thr Tyr Lys Gln Met Val Gly Arg Ala 
465                 470                 475                 480 


Gly Arg Lys Gly Val Asp Thr Met Gly Glu Ser Ile Leu Val Cys Lys 
                485                 490                 495     


Asn Ser Glu Lys Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser Leu Glu 
            500                 505                 510         


Pro Val His Ser Cys Leu Gln Arg Gln Gly Glu Val Thr Ala Ser Met 
        515                 520                 525             


Ile Arg Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala Ser Thr Ser 
    530                 535                 540                 


Gln Asp Met Gln Thr Tyr Ala Ala Cys Thr Phe Leu Ala Ala Ala Ile 
545                 550                 555                 560 


Gln Glu Gly Lys Gln Gly Met Gln Arg Asn Gln Asp Asp Ala Gln Leu 
                565                 570                 575     


Gly Ala Ile Asp Ala Cys Val Thr Trp Leu Leu Glu Asn Glu Phe Ile 
            580                 585                 590         


Gln Val Ala Glu Pro Gly Asp Gly Thr Gly Gly Lys Val Tyr His Pro 
        595                 600                 605             


Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser Pro Thr Asp 
    610                 615                 620                 


Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met Lys Gly Phe Val 
625                 630                 635                 640 


Leu Glu Asn Asp Leu His Ile Val Tyr Leu Val Thr Pro Val Phe Glu 
                645                 650                 655     


Asp Trp Ile Ser Ile Asp Trp Tyr Arg Phe Phe Cys Leu Trp Glu Lys 
            660                 665                 670         


Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val Gly Val Glu Glu 
        675                 680                 685             


Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val Ala Arg Thr Glu 
    690                 695                 700                 


Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe Thr Ser Leu 
705                 710                 715                 720 


Val Leu Leu Asp Leu Ile Ser Glu Ile Pro Leu Lys Asp Ile Asn Gln 
                725                 730                 735     


Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln Gln Ser Ala 
            740                 745                 750         


Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn Arg Leu Gly Trp 
        755                 760                 765             


His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg Leu Thr Phe 
    770                 775                 780                 


Gly Ile Gln Arg Glu Leu Cys Asp Leu Ile Arg Val Ser Leu Leu Asn 
785                 790                 795                 800 


Ala Gln Arg Ala Arg Phe Leu Tyr Ala Ser Gly Phe Leu Thr Val Ala 
                805                 810                 815     


Asp Leu Ala Arg Ala Asp Ser Ala Glu Val Glu Val Ala Leu Lys Asn 
            820                 825                 830         


Ser Leu Pro Phe Lys Ser Ala Arg Lys Ala Val Asp Glu Glu Glu Glu 
        835                 840                 845             


Ala Ala Glu Glu Arg Arg Ser Met Arg Thr Ile Trp Val Thr Gly Lys 
    850                 855                 860                 


Gly Leu Ser Ala Arg Glu Ala Ala Ala Leu Ile Val Glu Glu Ala Lys 
865                 870                 875                 880 


Met Ile Leu Gln Gln Asp Leu Ile Glu Met Gly Val Arg Trp Asp Pro 
                885                 890                 895     


Lys Ser Pro Leu Ser Ser Ser Thr His Ser Arg Thr Ser Thr Ser Glu 
            900                 905                 910         


Val Lys Glu His Thr Phe Lys Ser Gln Thr Lys Ser Ser His Lys Arg 
        915                 920                 925             


Leu Ala Ser Met Gly Arg Asn Ser Ile Arg Ala Ser Gly Ser Asn Asp 
    930                 935                 940                 


Lys Pro Ser Pro Asp Ala Glu Arg Gly Ile Asp Asp Cys Ser Glu His 
945                 950                 955                 960 


Ala Asp Ser Leu Cys Lys Phe Gln Gly Asn Phe Glu Pro Gln Thr Pro 
                965                 970                 975     


Ser Ile Cys Thr Ala Arg Lys Arg Thr Ser Leu Gly Ile Asn Lys Glu 
            980                 985                 990         


Met Leu Arg Lys Ser Leu Lys Glu  Gly Lys Pro Ser Thr  Lys Glu Val 
        995                 1000                 1005             


Leu Gln  Thr Phe Ser Ser Glu  Lys Thr Arg Lys Thr  Ala Leu Ser 
    1010                 1015                 1020             


Phe Ser  Ser Glu Gln Val Asn  Asn Thr Leu Pro Ser  Gly Arg Asp 
    1025                 1030                 1035             


Arg Lys  Tyr Gln Lys Lys Ser  Trp Gly Ser Ser Pro  Val Arg Asp 
    1040                 1045                 1050             


Ser Gly  Met His Arg Gly Asp  Leu Gln Gly Gln Thr  Met Cys Thr 
    1055                 1060                 1065             


Ser Ala  Leu Cys Glu Asp Ser  Gln Lys Ser Leu Glu  Glu Gln Asn 
    1070                 1075                 1080             


Ala Glu  Phe Arg Ser Pro Gly  Leu Phe Ala Lys His  Leu Pro Ser 
    1085                 1090                 1095             


Cys Ala  Lys Glu Lys Cys Lys  Lys Pro Ser Leu Pro  Leu Gln Arg 
    1100                 1105                 1110             


Gln Gln  Ala Cys Ser Arg Arg  Ser Thr Glu Ser Cys  Ala Ala Val 
    1115                 1120                 1125             


Gly His  Pro Ala Ala Gly Ser  Ser Pro Ala Ala Ala  Arg Asp Arg 
    1130                 1135                 1140             


Arg Gly  Leu Ala Ala Arg Glu  Thr Glu Lys Gly Asn  Glu Ala Leu 
    1145                 1150                 1155             


Thr Glu  Asn Gly Gly Glu Ser  Gln Leu Gln Asp Thr  Tyr Pro Val 
    1160                 1165                 1170             


Ser Gln  Tyr Leu Glu Tyr His  Ser Glu Lys His Thr  Asn Thr Cys 
    1175                 1180                 1185             


Thr Arg  Gln Lys Thr Leu Thr  Glu Gly Gln Ala Gly  Ser Ser Tyr 
    1190                 1195                 1200             


Val Ala  Arg Asp Ser Asn Asp  Ala Ala Pro Ile Lys  Cys Glu Arg 
    1205                 1210                 1215             


Met Lys  Leu Asn Ser Lys Asp  Arg Asp Ser Asn Pro  Cys Arg Gln 
    1220                 1225                 1230             


Ala Leu  Gly Ser Tyr Thr Gly  Arg Thr Glu Ala Leu  Gln Ser Thr 
    1235                 1240                 1245             


Ala Lys  Leu Gly Gln Ala Gly  Gly Gln Cys Glu Asn  Leu Leu Asn 
    1250                 1255                 1260             


Ser Ser  Gly Val Gln Gly Lys  Thr Gly Ala His Ala  Thr Asn Arg 
    1265                 1270                 1275             


Thr Glu  His Ser His Ala Ser  Asn Pro Ala Phe Cys  Asp Phe Gly 
    1280                 1285                 1290             


Asp Ser  Leu Asp Leu Asp Thr  Gln Ser Glu Glu Ile  Ile Glu Gln 
    1295                 1300                 1305             


Met Ala  Thr Glu Asn Thr Met  Gln Gly Ala Lys Ala  Val Val Ile 
    1310                 1315                 1320             


Met Glu  Glu Gly Ser Ala Met  Gln Asn Lys Cys His  Ser Thr Pro 
    1325                 1330                 1335             


Gly Asp  Gln His Val Pro Gly  Ala Ala Asn Thr Asp  His Val Asp 
    1340                 1345                 1350             


Ser Lys  Lys Val Glu Ser Val  Lys Ala Asn Thr Glu  Lys Asn Ile 
    1355                 1360                 1365             


Asn Arg  Gly Ala Pro Val Ser  Leu Ile Phe His Thr  Gln Gly Glu 
    1370                 1375                 1380             


Asn Gly  Ala Cys Phe Lys Gly  Asn Glu His Ser Val  Thr Asp Ser 
    1385                 1390                 1395             


Gln Leu  Asn Ser Phe Leu Gln  Gly Phe Glu Thr Gln  Glu Ile Val 
    1400                 1405                 1410             


Lys Pro  Ile Ile Pro Leu Ala  Pro Gln Met Arg Thr  Pro Thr Gly 
    1415                 1420                 1425             


Val Glu  Glu Glu Ser Leu Pro  Glu Thr Ser Leu Asn  Met Ser Asp 
    1430                 1435                 1440             


Ser Ile  Leu Phe Asp Ser Phe  Gly Glu Asp Gly Phe  Gly Gln Gly 
    1445                 1450                 1455             


Gln Ser  Pro Asp Ile Lys Ala  Asn Gln Pro Leu Leu  Ser Glu Met 
    1460                 1465                 1470             


Thr Pro  Asn His Phe Ser Asn  Pro Pro His Pro Gln  Glu Asp Pro 
    1475                 1480                 1485             


Val Met  Thr Pro Thr Val Ser  Glu Pro Gln Gly Thr  Gln Gln Gln 
    1490                 1495                 1500             


Gly Val  Cys Leu Ser Gly Glu  Ser Ile Ile Phe Ser  Asp Ile Asp 
    1505                 1510                 1515             


Ser Ala  Gln Val Ile Glu Ala  Leu Asp Asn Met Ala  Ala Phe His 
    1520                 1525                 1530             


Val Gln  Glu Asn Cys Asn Ser  Val Ala Leu Lys Thr  Leu Glu Pro 
    1535                 1540                 1545             


Ser Asp  Ser Ala Val Leu Gly  Asn Glu Cys Pro Gln  Gly Lys Leu 
    1550                 1555                 1560             


Val Arg  Gly Asp Gln Asn Glu  Gly Ser Pro Lys Pro  Lys Leu Thr 
    1565                 1570                 1575             


Glu Thr  Asn Gln Asp Asn Ser  Phe Thr Trp Ser Gly  Ala Ser Phe 
    1580                 1585                 1590             


Asn Leu  Ser Pro Glu Leu Gln  Arg Ile Leu Asp Lys  Val Ser Ser 
    1595                 1600                 1605             


Pro Arg  Glu Asn Glu Lys Pro  Lys Met Ile His Val  Asn Leu Ser 
    1610                 1615                 1620             


Ser Phe  Glu Gly Asn Ser Lys  Glu Ser His Glu Arg  Glu Glu Ile 
    1625                 1630                 1635             


Asn Ser  Asp Leu Gly Thr Val  Gln Arg Thr Ser Val  Phe Pro Ser 
    1640                 1645                 1650             


Asn Glu  Val Lys Asn Arg Thr  Glu Gly Leu Glu Ser  Lys Ala Arg 
    1655                 1660                 1665             


His Gly  Gly Ala Ser Ser Pro  Leu Pro Arg Lys Glu  Ser Ala Ala 
    1670                 1675                 1680             


Ala Asp  Asp Asn Gly Leu Ile  Pro Pro Thr Pro Val  Pro Ala Ser 
    1685                 1690                 1695             


Ala Ser  Lys Val Ala Phe Pro  Glu Ile Leu Gly Thr  Ser Val Lys 
    1700                 1705                 1710             


Arg Gln  Lys Ala Ser Ser Ala  Leu Gln Pro Gly Glu  Ser Cys Leu 
    1715                 1720                 1725             


Phe Gly  Ser Pro Ser Asp Asn  Gln Asn Gln Asp Leu  Ser Gln Glu 
    1730                 1735                 1740             


Leu Arg  Asp Ser Leu Lys Asp  Tyr Asp Gly Ser Val  Ala Asp Thr 
    1745                 1750                 1755             


Ser Phe  Phe Leu Gln Ser Gln  Asp Gly Leu Leu Leu  Thr Gln Ala 
    1760                 1765                 1770             


Ser Cys  Ser Ser Glu Ser Leu  Ala Ile Ile Asp Val  Ala Ser Asp 
    1775                 1780                 1785             


Gln Ile  Leu Phe Gln Thr Phe  Val Lys Glu Trp Gln  Cys Gln Lys 
    1790                 1795                 1800             


Arg Phe  Ser Ile Ser Leu Ala  Cys Glu Lys Met Thr  Ser Ser Met 
    1805                 1810                 1815             


Ser Ser  Lys Thr Ala Thr Ile  Gly Gly Lys Leu Lys  Gln Val Ser 
    1820                 1825                 1830             


Leu Pro  Gln Glu Ala Thr Val  Glu Asp Ala Gly Phe  Pro Val Arg 
    1835                 1840                 1845             


Gly Cys  Asp Gly Ala Val Val  Val Gly Leu Ala Val  Cys Trp Gly 
    1850                 1855                 1860             


Ala Lys  Asp Ala Tyr Tyr Leu  Ser Leu Gln Lys Glu  Gln Lys Gln 
    1865                 1870                 1875             


Ser Glu  Ile Ser Pro Ser Leu  Ala Pro Pro Pro Leu  Asp Ala Thr 
    1880                 1885                 1890             


Leu Thr  Val Lys Glu Arg Met  Glu Cys Leu Gln Ser  Cys Leu Gln 
    1895                 1900                 1905             


Lys Lys  Ser Asp Arg Glu Arg  Ser Val Val Thr Tyr  Asp Phe Ile 
    1910                 1915                 1920             


Gln Thr  Tyr Lys Val Leu Leu  Leu Ser Cys Gly Ile  Ser Leu Glu 
    1925                 1930                 1935             


Pro Ser  Tyr Glu Asp Pro Lys  Val Ala Cys Trp Leu  Leu Asp Pro 
    1940                 1945                 1950             


Asp Ser  Lys Glu Pro Thr Leu  His Ser Ile Val Thr  Ser Phe Leu 
    1955                 1960                 1965             


Pro His  Glu Leu Ala Leu Leu  Glu Gly Met Glu Thr  Gly Pro Gly 
    1970                 1975                 1980             


Ile Gln  Ser Leu Gly Leu Asn  Val Asn Thr Glu His  Ser Gly Arg 
    1985                 1990                 1995             


Tyr Arg  Ala Ser Val Glu Ser  Val Leu Ile Phe Asn  Ser Met Asn 
    2000                 2005                 2010             


Gln Leu  Asn Ser Leu Leu Gln  Lys Glu Asn Leu His  Asp Ile Phe 
    2015                 2020                 2025             


Cys Lys  Val Glu Met Pro Ser  Gln Tyr Cys Leu Ala  Leu Leu Glu 
    2030                 2035                 2040             


Leu Asn  Gly Ile Gly Phe Ser  Thr Ala Glu Cys Glu  Ser Gln Lys 
    2045                 2050                 2055             


His Val  Met Gln Ala Lys Leu  Asp Ala Ile Glu Thr  Gln Ala Tyr 
    2060                 2065                 2070             


Gln Leu  Ala Gly His Ser Phe  Ser Phe Thr Ser Ala  Asp Asp Ile 
    2075                 2080                 2085             


Ala Gln  Val Leu Phe Leu Glu  Leu Lys Leu Pro Pro  Asn Gly Glu 
    2090                 2095                 2100             


Met Lys  Thr Gln Gly Ser Lys  Lys Thr Leu Gly Ser  Thr Arg Arg 
    2105                 2110                 2115             


Gly Asn  Glu Ser Gly Arg Arg  Met Arg Leu Gly Arg  Gln Phe Ser 
    2120                 2125                 2130             


Thr Ser  Lys Asp Ile Leu Asn  Lys Leu Lys Gly Leu  His Pro Leu 
    2135                 2140                 2145             


Pro Gly  Leu Ile Leu Glu Trp  Arg Arg Ile Ser Asn  Ala Ile Thr 
    2150                 2155                 2160             


Lys Val  Val Phe Pro Leu Gln  Arg Glu Lys His Leu  Asn Pro Leu 
    2165                 2170                 2175             


Leu Arg  Met Glu Arg Ile Tyr  Pro Val Ser Gln Ser  His Thr Ala 
    2180                 2185                 2190             


Thr Gly  Arg Ile Thr Phe Thr  Glu Pro Asn Ile Gln  Asn Val Pro 
    2195                 2200                 2205             


Arg Asp  Phe Glu Ile Lys Met  Pro Thr Leu Val Arg  Glu Ser Pro 
    2210                 2215                 2220             


Pro Ser  Gln Ala Pro Lys Gly  Arg Phe Pro Met Ala  Ile Gly Gln 
    2225                 2230                 2235             


Asp Lys  Lys Val Tyr Gly Leu  His Pro Gly His Arg  Thr Gln Met 
    2240                 2245                 2250             


Glu Glu  Lys Ala Ser Asp Arg  Gly Val Pro Phe Ser  Val Ser Met 
    2255                 2260                 2265             


Arg His  Ala Phe Val Pro Phe  Pro Gly Gly Leu Ile  Leu Ala Ala 
    2270                 2275                 2280             


Asp Tyr  Ser Gln Leu Glu Leu  Arg Ile Leu Ala His  Leu Ser Arg 
    2285                 2290                 2295             


Asp Cys  Arg Leu Ile Gln Val  Leu Asn Thr Gly Ala  Asp Val Phe 
    2300                 2305                 2310             


Arg Ser  Ile Ala Ala Glu Trp  Lys Met Ile Glu Pro  Asp Ala Val 
    2315                 2320                 2325             


Gly Asp  Asp Leu Arg Gln His  Ala Lys Gln Ile Cys  Tyr Gly Ile 
    2330                 2335                 2340             


Ile Tyr  Gly Met Gly Ala Lys  Ser Leu Gly Glu Gln  Met Gly Ile 
    2345                 2350                 2355             


Lys Glu  Asn Asp Ala Ala Ser  Tyr Ile Asp Ser Phe  Lys Ser Arg 
    2360                 2365                 2370             


Tyr Lys  Gly Ile Asn His Phe  Met Arg Asp Thr Val  Lys Asn Cys 
    2375                 2380                 2385             


Arg Lys  Asn Gly Phe Val Glu  Thr Ile Leu Gly Arg  Arg Arg Tyr 
    2390                 2395                 2400             


Leu Pro  Gly Ile Lys Asp Asp  Asn Pro Tyr His Lys  Ala His Ala 
    2405                 2410                 2415             


Glu Arg  Gln Ala Ile Asn Thr  Thr Val Gln Gly Ser  Ala Ala Asp 
    2420                 2425                 2430             


Ile Val  Lys Ile Ala Thr Val  Asn Ile Gln Lys Gln  Leu Glu Thr 
    2435                 2440                 2445             


Phe Arg  Ser Thr Phe Lys Ser  His Gly His Arg Glu  Ser Met Leu 
    2450                 2455                 2460             


Gln Asn  Asp Arg Thr Gly Leu  Leu Pro Lys Arg Lys  Leu Lys Gly 
    2465                 2470                 2475             


Met Phe  Cys Pro Met Arg Gly  Gly Phe Phe Ile Leu  Gln Leu His 
    2480                 2485                 2490             


Asp Glu  Leu Leu Tyr Glu Val  Ala Glu Glu Asp Val  Val Gln Val 
    2495                 2500                 2505             


Ala Gln  Ile Val Lys Asn Glu  Met Glu Cys Ala Ile  Lys Leu Ser 
    2510                 2515                 2520             


Val Lys  Leu Lys Val Lys Val  Lys Ile Gly Ala Ser  Trp Gly Glu 
    2525                 2530                 2535             


Leu Lys  Asp Phe Asp Val 
    2540                 


<210>  19
<211>  2397
<212>  DNA
<213>  artificial sequence

<220>
<223>  sequence of example 1

<400>  19
ggcttcaagg acaatagtcc gatcagtgac acttctttca gtttacagct gtcacaagac       60

ggccttcaat taacacctgc ctccagctca tccgaaagcc tttcgatcat tgacgtcgcc      120

tcggatcaaa atttgttcca gacctttatt aaagaatggc gttgcaaaaa acgcttcagt      180

atttcgttgg cgtgtgaaaa gatccgctct cttacgtcca gtaagacagc gacaatcggt      240

tcgcgcttca agcaggccag ctcaccccaa gagattccca tccgcgacga cggttttcct      300

atcaaagggt gtgatgacac tttggtggtg ggtctggcag tttgctgggg aggacgtgat      360

gcgtattact tcagcttgca gaaagaacaa aaacactccg aaatctctgc gtccttggtc      420

cccccttcat tggacccatc attaacgctt aaagatcgta tgtggtactt gcagagttgt      480

ttacgcaaag aaagcgacaa agaatgtagt gtggtcatct atgatttcat ccagagctac      540

aaaatcttgt tgttatcctg tggcatctct ctggagcaga gctatgaaga tccgaaggta      600

gcctgttggc ttttggaccc ggattcgcaa gagccaaccc tgcattcaat cgtcaccagc      660

ttccttccac atgaactgcc tcttttagag ggaatggaga cctcgcaggg aatccaatct      720

cttggactta atgctggatc tgaacacagt ggacgctatc gcgcgtcagt tgaatcaatc      780

ctgattttta actcgatgaa tcaacttaat tccctgcttc agaaagaaaa ccttcaggac      840

gtctttcgta aggtggaaat gccttcgcaa tattgcttag ccttattaga gttgaatgga      900

atcggatttt ccactgcaga gtgtgagtcc cagaaacata tcatgcaggc caaactggat      960

gcaatcgaga cacaagctta ccagcttgcg ggtcatagct tcagcttcac atcctccgac     1020

gatatcgccg aagtcttgtt tttggaatta aagctgcctc ctaatcgcga gatgaagaat     1080

caaggctcca agaagacatt aggttcaacc cgccgtggaa tcgacaatgg tcgtaaatta     1140

cgtctgggcc gccagtttag cacatctaaa gacgtcctta ataagctgaa agccttgcac     1200

cctcttccgg gcctgatttt ggagtggcgc cgtattacaa atgccatcac caaagtagtt     1260

ttcccattgc agcgcgagaa gtgtcttaat ccattccttg ggatggagcg tatctatccc     1320

gtcagccagt cacatactgc aacgggacgc attactttca cggagccaaa catccaaaat     1380

gtcccccgcg acttcgagat taaaatgcct actctggttg gggagtctcc tcctagccaa     1440

gctgtgggca agggactgct gcctatgggt cgtggcaaat acaaaaaggg ctttagtgtt     1500

aacccacgct gccaggctca gatggaggag cgcgctgcag atcgtggaat gcctttttct     1560

atcagcatgc gtcacgcatt cgtccccttc ccagggggaa gtatcttagc ggctgattac     1620

tctcaattgg aacttcgtat tctggcgcac cttagtcatg accgtcgctt gattcaggta     1680

ctgaatactg gagcggacgt gtttcgttcg attgctgcgg agtggaaaat gatcgagccc     1740

gaatccgtcg gtgatgatct tcgtcaacag gcaaaacaga tctgttacgg gatcatctat     1800

ggaatgggtg ctaaatcctt gggtgagcaa atggggatta aggagaacga tgccgcatgc     1860

tacattgata gcttcaaatc acgttacacc ggtattaatc aatttatgac tgagaccgtg     1920

aaaaactgta aacgtgacgg cttcgtccaa acaattttag ggcgtcgccg ctatttaccg     1980

ggaattaagg acaacaatcc ctaccgcaaa gcacatgccg aacgtcaagc aatcaacact     2040

attgtccaag gttcggctgc tgatatcgtg aaaattgcca cagtcaacat ccagaaacag     2100

ctggagacgt ttcattcaac atttaaaagc cacggacacc gtgaaggcat gctgcaatcg     2160

gaccaaactg gtctgtcacg taagcgtaaa ttgcagggta tgttctgtcc gattcgcgga     2220

ggcttcttta tcttacaatt acacgacgag ctgttgtatg aagttgccga ggaagatgtc     2280

gtccaggtgg ctcagattgt taagaacgaa atggaatctg ctgtgaagtt gtctgtgaag     2340

cttaaagtca aagttaaaat tggtgcttcg tggggggagt tgaaagactt cgatgtt        2397


