                               SEQUENCE LISTING

<110> SANGAMO THERAPEUTICS, INC.
 
<120> CHIMERIC ANTIGEN RECEPTOR MEDIATED CELL TARGETING

<130> 8325-0165.40

<140> PCT/US2018/045759
<141> 2018-08-08

<150> 62/652,672
<151> 2018-04-04

<150> 62/613,258
<151> 2018-01-03

<150> 62/581,290
<151> 2017-11-03

<150> 62/542,511
<151> 2017-08-08

<160> 70    

<170> PatentIn version 3.5

<210> 1
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
tcaagctggt cgagaaaagc tttgaaac                                          28


<210> 2
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
aacaggtaag acaggggtct agcctggg                                          28


<210> 3
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gccacggagc gagacatctc ggcccgaa                                          28


<210> 4
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
gagtagcgcg agcacagcta aggccacg                                          28


<210> 5
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
acccagatac aaacaatgga tagaaaac                                          28


<210> 6
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
tgcaaaaggt aggaaaagga ccaaccag                                          28


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gln Ser Ser Asp Leu Ser Arg 
1               5           


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gln Ser Gly Asn Arg Thr Thr 
1               5           


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Arg Ser Ala Asn Leu Ala Arg 
1               5           


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Asp Arg Ser Ala Leu Ala Arg 
1               5           


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Arg Ser Asp Val Leu Ser Glu 
1               5           


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Lys His Ser Thr Arg Arg Val 
1               5           


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Thr Met His Gln Arg Val Glu 
1               5           


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Thr Ser Gly His Leu Ser Arg 
1               5           


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Arg Ser Asp His Leu Thr Gln 
1               5           


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Asp Ser Ala Asn Leu Ser Arg 
1               5           


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gln Ser Gly Ser Leu Thr Arg 
1               5           


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ala Lys Trp Asn Leu Asp Ala 
1               5           


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Arg Ser Asp Val Leu Ser Ala 
1               5           


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gln Asn Ala Thr Arg Ile Asn 
1               5           


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gln Ser Gly Asp Leu Thr Arg 
1               5           


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Thr Ser Gly Asn Leu Thr Arg 
1               5           


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gln Ser Asn Asp Leu Asn Ser 
1               5           


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Arg Ser Asp Asp Leu Ser Lys 
1               5           


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Asp Ser Ser Ala Arg Lys Lys 
1               5           


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Asp Arg Ser Asn Leu Ser Arg 
1               5           


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gln Arg Thr His Leu Arg Asp 
1               5           


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gln Ser Gly His Leu Ala Arg 
1               5           


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Asp Ser Ser Asn Arg Glu Ala 
1               5           


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ala Gln Cys Cys Leu Phe His 
1               5           


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Asp Gln Ser Asn Leu Arg Ala 
1               5           


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Arg Ser Ala Asn Leu Thr Arg 
1               5           


<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Arg Ser Asp Asp Leu Thr Arg 
1               5           


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Arg Ser Asp Asn Leu Ser Val 
1               5           


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Arg Ser Asp Tyr Leu Ala Lys 
1               5           


<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gln Asn Ala Asn Arg Ile Thr 
1               5           


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ser Gly Thr Pro His Glu Val Gly Val Tyr Thr Leu 
1               5                   10          


<210> 38
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Ser Gly Ala Ile Arg Cys His Asp Glu Phe Trp Phe 
1               5                   10          


<210> 39
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
aggattcgga acccaatcac tgacaggt                                          28


<210> 40
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
ctcctgaaag tggccgggtt taatctgc                                          28


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Thr Ser Ser Asn Arg Lys Thr 
1               5           


<210> 42
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Leu Gln Gln Thr Leu Ala Asp 
1               5           


<210> 43
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gln Ser Gly Asn Leu Ala Arg 
1               5           


<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Arg Arg Glu Asp Leu Ile Thr 
1               5           


<210> 45
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Thr Ser Ser Asn Leu Ser Arg 
1               5           


<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Arg Ser Asp His Leu Ser Thr 
1               5           


<210> 47
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Asp Arg Ser His Leu Ala Arg 
1               5           


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Leu Lys Gln His Leu Asn Glu 
1               5           


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
His Asn Ser Ser Leu Lys Asp 
1               5           


<210> 50
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
ggaaggcccc agcaggcaag ggctgcat                                          28


<210> 51
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
gaggaggtgg cagagggtac cccagccc                                          28


<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Arg Ser Asp His Leu Ser Gln 
1               5           


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Gln Asn Ala Thr Arg Thr Lys 
1               5           


<210> 54
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Arg Ser Asp Asn Leu Ser Glu 
1               5           


<210> 55
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Lys Arg Cys Asn Leu Arg Cys 
1               5           


<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Asp Arg Ser Thr Arg Thr Lys 
1               5           


<210> 57
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Arg Arg Asp Asn Leu His Ser 
1               5           


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Gly His Thr Ser Leu Lys Arg 
1               5           


<210> 59
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Arg Ser Asp Asn Leu Ala Arg 
1               5           


<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Gln Asn Val Ser Arg Pro Arg 
1               5           


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Gln Ser Gly His Leu Ser Arg 
1               5           


<210> 62
<211> 100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 62
aagcccataa ccgctgtggc ctcttggttt tacagatacg aacctaaact ttcaaaacct       60

gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc                            100


<210> 63
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      'LAGLIDADG' family peptide motif sequence

<400> 63
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 64
<211> 592
<212> DNA
<213> Woodchuck hepatitis virus

<400> 64
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210> 65
<211> 424
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      T cell receptor enhancer sequence

<400> 65
gatatcattg gtcaattgca gcagacatgt ctcttgtggt gtaaagcctc atagcatctt       60

cctgctggag tccacctggc agcccaaagc ctcagcaagt gctggggaca gagagataga      120

aaggctttgc tgtggctcaa ctcagttgta ctttctcaag ctccttttgg ttatctgctc      180

tgtctatgta gttgcttcct ggaaaatggt taaagtcaaa cctcctctgt ttggggcagc      240

acaaaatgtt gctaaggcgt tagaagacaa cataggagca gttaaaccac agccagtttt      300

tgctcgcttt cgaaagacca cagctattag acagaaaacc tcctgtactg gaagtggccc      360

tgaaacagca tctgtgctga cagacactgg gcttgctatg gttgctgctc atcatgctca      420

gctg                                                                   424


<210> 66
<211> 83
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      T cell receptor alpha enhancer sequence

<400> 66
ctcccatttc catgacgtca tggttaaacc tcttttacct gctttaaccc tttgaagctc       60

tcccgcagaa gccacatcct ctg                                               83


<210> 67
<211> 50
<212> DNA
<213> Xenopus sp.

<400> 67
tgcttgttct ttttgcagaa gctcagaata aacgctcaac tttggcagat                  50


<210> 68
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Gly Gly Gly Gly Ser 
1               5   


<210> 69
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 70
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Gln Leu Val Lys Ser 
1               5   


