                         SEQUENCE LISTING

<110>  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF 
       ARIZONA
       Polt, Robin
       Apostol, Christopher
       Heien, Michael
       Liu, Chenxi
 
<120>  GLYCOPEPTIDE ANALOGS OF SECRETIN FAMILY PEPTIDES

<130>  UNIA 17.35 PCT

<140>  PCT/US 18/046136
<141>  2018-08-09

<150>  62/543,152
<151>  2017-08-09

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  2
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  2

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Ser may be glycosylated

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Ser may be glycosylated

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  M or Nle

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  L or S

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa may be glycosylated Ser

<400>  3

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  4
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VIP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  M or Nle

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Ser may be glycosylated

<400>  4

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  5
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Glycosylated Ser

<400>  5

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  6
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Glycosylated Ser

<400>  6

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<400>  7

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  8
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Glycosylated Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<400>  8

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  9
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Glycosylated Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<400>  9

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  10
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<400>  10

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Ser 
            20                  25          


<210>  11
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Glycosylated Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<400>  11

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Ser 
            20                  25          


<210>  12
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Glycosylated Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<400>  12

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Ser 
            20                  25          


<210>  13
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Glycosylated Ser

<400>  13

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Ser 
            20                  25          


<210>  14
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VIP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Glycosylated Ser

<400>  14

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  15
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VIP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<400>  15

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  16
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VIP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser or L-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Nle

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Glycosylated Ser

<400>  16

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  17
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ser(Lactose)

<400>  17

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Leu Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Ser 
            20                  25              


<210>  18
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ser(Melibiose)

<400>  18

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Leu Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Ser 
            20                  25              


<210>  19
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Ser(Cellobiose)

<400>  19

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Leu Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Ser 
            20                  25              


<210>  20
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Norvaline

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  L-Serine-beta-D-Glucoside

<400>  20

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Ser 
            20                  25              


<210>  21
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Norvaline

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  L-Serine-beta-D-Glucoside

<400>  21

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Ser 
            20                  25          


<210>  22
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Norvaline

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  L-Serine-beta-D-Glucoside

<400>  22

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Ser Leu 
            20                  25          


<210>  23
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Norvaline

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  L-Serine-beta-D-Lactoside

<400>  23

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Ser 
            20                  25              


<210>  24
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Norvaline

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  L-Serine-beta-D-Lactoside

<400>  24

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Ser 
            20                  25          


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP glycopeptide analog


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  D-Ser

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Norvaline

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  L-Serine-beta-D-Lactoside

<400>  25

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Ser Leu 
            20                  25          


