                         SEQUENCE LISTING

<110>  Apterna Limited
       City of Hope
 
<120>  Bispecific Antigen-Binding Molecule

<130>  RIC/LP7277742

<140>  PCT/US18/46342
<141>  2018-08-10

<150>  US 62/544220
<151>  2017-08-11

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tP19 (mortalin-binding)

<400>  1
cucaauggcg aaugcccgcc uaauaggg                                          28


<210>  2
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P19 (mortalin-binding)

<400>  2
gggagacaag aauaaacgcu caauggcgaa ugcccgccua auagggcguu augacuuguu       60

gaguucgaca ggaggcucac aacaggc                                           87


<210>  3
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P1 (mortalin-binding)

<400>  3
gggagacaag aauaaacgcu caaugcgcug aaugcccagc cgugaaagcg ucgauuucca       60

uccuucgaca ggaggcucac aacaggc                                           87


<210>  4
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P15 (vimentin-binding)

<400>  4
gggagacaag aauaaacgcu caaaguugcg gcccaaccgu uuaauucaga auagugugau       60

gccuucgaca ggaggcucac aacaggc                                           87


<210>  5
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P11 (HSP90-binding)

<400>  5
gggagacaag aauaaacgcu caaaugauug cccauucggu uaugcuugcg cuuccuaaag       60

agcuucgaca ggaggcucac aacaggc                                           87


<210>  6
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P7 (HSP90-binding)

<400>  6
gggagacaag aauaaacgcu caaggccaug uugaaugccc aacuaagcuu ugagcuuugg       60

agcuucgaca ggaggcucac aacaggc                                           87


<210>  7
<211>  71
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P6 (HSP90-binding)

<400>  7
gggagacaag aauaaacgcu caacaaugga gcguuaaacg ugagccauuc gacaggaggc       60

ucacaacagg c                                                            71


<210>  8
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  P19, P1, P7 consensus

<400>  8
gaaugccc                                                                 8


<210>  9
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TR14 (TfR-binding)

<400>  9
gggagacaag aauaaacgcu caaugcguuc acguuuauuc acauuuuuga auugagcaug       60

agcuucgaca ggaggcucac aacaggc                                           87


<210>  10
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TR18 (TfR-binding)

<400>  10
gggagacaag aauaaacgcu caaugcguuu acguuuauuc acauuuuuga auugagcaug       60

agcuucgaca ggaggcucac aacaggc                                           87


<210>  11
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Truncated TR14 (TfR-binding)

<400>  11
ggggcucaau gcguucacgu uuauucacau uuuugaauug agc                         43


<210>  12
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDR3 (PDGFR-a-binding)

<400>  12
gggagagcgg aagcgugcug ggccugcucu uuaauaaacc cacuuucgaa caucagcgua       60

uguccauaac ccagagguga uggauccccc                                        90


<210>  13
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PDR9 (PDGFR-a-binding)

<400>  13
gggagagcgg aagcgugcug ggccuauugc aucuuucugu uauuuccgaa uccgucccga       60

cugucauaac ccagagguga uggauccccc                                        90


<210>  14
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  G3 (CCR5-binding)

<400>  14
gggaggacga ugcgggccuu cguuuguuuc guccacagac gacucgcccg a                51


<210>  15
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  C3e2 (CD3E-binding)

<400>  15
ggagacaaga auaaacgcuc aaauagaagc agcaucuucc aaaucaguuu guguguccuc       60

uauucgacag gaggcucaca acaggc                                            86


<210>  16
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  C3e3 (CD3E-binding)

<400>  16
gggagacaag aauaaacgcu caaaugccug uaguucguag cgauuuaacu gcgucaguga       60

ggcuucgaca ggaggcucac aacaggc                                           87


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 VL

<400>  17

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 LC-CDR1

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 LC-CDR2

<400>  19

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 LC-CDR3

<400>  20

Trp Gln Gly Thr His Phe Pro Arg Thr 
1               5                   


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 VH

<400>  21

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 HC-CDR1

<400>  22

Ser Tyr Trp Met His 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 HC-CDR2

<400>  23

Glu Ile Asp Pro Ser Asp Ser Tyr Thr Lys Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  36-7 HC-CDR3

<400>  24

Gly Asp Tyr 
1           


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 VL

<400>  25

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 LC-CDR1

<400>  26

Arg Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 LC-CDR2

<400>  27

Asp Thr Ser Lys Val Ala Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 LC-CDR3

<400>  28

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  29
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 VH

<400>  29

Asp Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 HC-CDR1

<400>  30

Arg Tyr Thr Met His 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 HC-CDR2

<400>  31

Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MT-103 HC-CDR3

<400>  32

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  33
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  36-7 VL nucleotide

<400>  33
gacgtggtga tgacccagac cccgctgacc ctgagtgtaa cgatcggcca gcccgccagt       60

atcagctgta agagcagtca aagcctgctg gacagcgacg gcaagaccta cctgaactgg      120

ctgcttcaaa ggccgggaca gagccccaag aggctcatct acctggtgag caagctggac      180

tcaggcgtgc ccgacaggtt caccgggagc gggagtggca ccgacttcac cctgaagatc      240

agcagggtag aggccgagga cctgggtgtg tactactgct ggcagggaac ccattttccc      300

aggactttcg gaggcgggac caaactggaa atcaagcga                             339


<210>  34
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  36-7 VH nucleotide

<400>  34
caggtgcagc tccaacagcc aggtgccgag ctggtaaaac ctggcgcgtc agtgaagctg       60

agttgtaaag caagcggcta caccttcacc agctactgga tgcactgggt taagcagagg      120

ccaggccaag gcctggagtg gatcggcgag atcgacccca gcgacagtta caccaagtac      180

aaccagaagt tcaagggcaa ggcaaccctc acggtcgata agtcaagcag caccgcgtac      240

atgcaactta gtagcctgac cagcgaggat agcgcggtct actattgcgc cagaggcgac      300

tactggggcc agggcaccac tttgaccgtg tctagt                                336


<210>  35
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MT-103 VL nucleotide

<400>  35
gacatccagc tgacccagag ccctgccatc atgagcgcca gtcctggcga gaaggtgacc       60

atgacctgta gggcctctag ctcagtgagc tacatgaact ggtatcaaca gaaaagcggc      120

acgagcccca agaggtggat ctacgacacc agcaaagtgg cgtcaggcgt accttatagg      180

tttagcggct caggatcagg caccagctac agcctgacca tcagctctat ggaggccgaa      240

gacgccgcca cctattattg ccagcagtgg tctagcaacc ccctgacctt cggagccggc      300

accaaactgg aactgaag                                                    318


<210>  36
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MT-103 VH nucleotide

<400>  36
gacatcaaac ttcagcagag cggcgctgag ctggctcgac caggcgcgag cgtgaagatg       60

agctgcaaga ccagtggcta taccttcacc aggtacacca tgcactgggt gaagcaacga      120

cctggacagg gactggagtg gatcggctac atcaacccca gcaggggcta caccaactac      180

aaccagaagt tcaaggacaa ggcgaccctg acgaccgaca agagcagcag caccgcctac      240

atgcagctga gcagtctcac cagcgaggac agcgcggtgt actactgcgc aaggtactac      300

gacgaccact attgcctgga ctactggggc cagggcacca cgctgacggt gagctct         357


<210>  37
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ile Ser Ala Ser Arg Ala Ala Ala Ala Arg Leu Val Gly Ala Ala 
1               5                   10                  15      


Ala Ser Arg Gly Pro Thr Ala Ala Arg His Gln Asp Ser Trp Asn Gly 
            20                  25                  30          


Leu Ser His Glu Ala Phe Arg Leu Val Ser Arg Arg Asp Tyr Ala Ser 
        35                  40                  45              


Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr Thr Asn 
    50                  55                  60                  


Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu Glu Asn 
65                  70                  75                  80  


Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr Ala Asp 
                85                  90                  95      


Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val Thr Asn 
            100                 105                 110         


Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg Arg Tyr 
        115                 120                 125             


Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe Lys Ile 
    130                 135                 140                 


Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly Lys Leu 
145                 150                 155                 160 


Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met Lys Glu 
                165                 170                 175     


Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val Ile Thr 
            180                 185                 190         


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
        195                 200                 205             


Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu Pro Thr 
    210                 215                 220                 


Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys Val Ile 
225                 230                 235                 240 


Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile Leu Glu 
                245                 250                 255     


Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp Thr Phe 
            260                 265                 270         


Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile Val Lys 
        275                 280                 285             


Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn Met Ala 
    290                 295                 300                 


Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu Leu Ser 
305                 310                 315                 320 


Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met Asp Ser 
                325                 330                 335     


Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln Phe Glu 
            340                 345                 350         


Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys Gln Lys 
        355                 360                 365             


Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu Val Ile 
    370                 375                 380                 


Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr Val Gln 
385                 390                 395                 400 


Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp Glu Ala 
                405                 410                 415     


Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly Asp Val 
            420                 425                 430         


Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly Ile Glu 
        435                 440                 445             


Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr Thr Ile 
    450                 455                 460                 


Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly Gln Thr 
465                 470                 475                 480 


Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala Gly Asp 
                485                 490                 495     


Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro Ala Pro 
            500                 505                 510         


Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala Asn Gly 
        515                 520                 525             


Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu Gln Gln 
    530                 535                 540                 


Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile Glu Asn 
545                 550                 555                 560 


Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg Lys Lys 
                565                 570                 575     


Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His Asp Thr 
            580                 585                 590         


Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp Glu Cys 
        595                 600                 605             


Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu Ala Arg 
    610                 615                 620                 


Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser Ser Leu 
625                 630                 635                 640 


Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys Met Ala 
                645                 650                 655     


Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln Lys Glu 
            660                 665                 670         


Asp Gln Lys Glu Glu Lys Gln 
        675                 


<210>  38
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Ser Glu Ala Ile Lys Gly Ala Val Val Gly Ile Asp Leu Gly Thr 
1               5                   10                  15      


Thr Asn Ser Cys Val Ala Val Met Glu Gly Lys Gln Ala Lys Val Leu 
            20                  25                  30          


Glu Asn Ala Glu Gly Ala Arg Thr Thr Pro Ser Val Val Ala Phe Thr 
        35                  40                  45              


Ala Asp Gly Glu Arg Leu Val Gly Met Pro Ala Lys Arg Gln Ala Val 
    50                  55                  60                  


Thr Asn Pro Asn Asn Thr Phe Tyr Ala Thr Lys Arg Leu Ile Gly Arg 
65                  70                  75                  80  


Arg Tyr Asp Asp Pro Glu Val Gln Lys Asp Ile Lys Asn Val Pro Phe 
                85                  90                  95      


Lys Ile Val Arg Ala Ser Asn Gly Asp Ala Trp Val Glu Ala His Gly 
            100                 105                 110         


Lys Leu Tyr Ser Pro Ser Gln Ile Gly Ala Phe Val Leu Met Lys Met 
        115                 120                 125             


Lys Glu Thr Ala Glu Asn Tyr Leu Gly His Thr Ala Lys Asn Ala Val 
    130                 135                 140                 


Ile Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys 
145                 150                 155                 160 


Asp Ala Gly Gln Ile Ser Gly Leu Asn Val Leu Arg Val Ile Asn Glu 
                165                 170                 175     


Pro Thr Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Ser Glu Asp Lys 
            180                 185                 190         


Val Ile Ala Val Tyr Asp Leu Gly Gly Gly Thr Phe Asp Ile Ser Ile 
        195                 200                 205             


Leu Glu Ile Gln Lys Gly Val Phe Glu Val Lys Ser Thr Asn Gly Asp 
    210                 215                 220                 


Thr Phe Leu Gly Gly Glu Asp Phe Asp Gln Ala Leu Leu Arg His Ile 
225                 230                 235                 240 


Val Lys Glu Phe Lys Arg Glu Thr Gly Val Asp Leu Thr Lys Asp Asn 
                245                 250                 255     


Met Ala Leu Gln Arg Val Arg Glu Ala Ala Glu Lys Ala Lys Cys Glu 
            260                 265                 270         


Leu Ser Ser Ser Val Gln Thr Asp Ile Asn Leu Pro Tyr Leu Thr Met 
        275                 280                 285             


Asp Ser Ser Gly Pro Lys His Leu Asn Met Lys Leu Thr Arg Ala Gln 
    290                 295                 300                 


Phe Glu Gly Ile Val Thr Asp Leu Ile Arg Arg Thr Ile Ala Pro Cys 
305                 310                 315                 320 


Gln Lys Ala Met Gln Asp Ala Glu Val Ser Lys Ser Asp Ile Gly Glu 
                325                 330                 335     


Val Ile Leu Val Gly Gly Met Thr Arg Met Pro Lys Val Gln Gln Thr 
            340                 345                 350         


Val Gln Asp Leu Phe Gly Arg Ala Pro Ser Lys Ala Val Asn Pro Asp 
        355                 360                 365             


Glu Ala Val Ala Ile Gly Ala Ala Ile Gln Gly Gly Val Leu Ala Gly 
    370                 375                 380                 


Asp Val Thr Asp Val Leu Leu Leu Asp Val Thr Pro Leu Ser Leu Gly 
385                 390                 395                 400 


Ile Glu Thr Leu Gly Gly Val Phe Thr Lys Leu Ile Asn Arg Asn Thr 
                405                 410                 415     


Thr Ile Pro Thr Lys Lys Ser Gln Val Phe Ser Thr Ala Ala Asp Gly 
            420                 425                 430         


Gln Thr Gln Val Glu Ile Lys Val Cys Gln Gly Glu Arg Glu Met Ala 
        435                 440                 445             


Gly Asp Asn Lys Leu Leu Gly Gln Phe Thr Leu Ile Gly Ile Pro Pro 
    450                 455                 460                 


Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala 
465                 470                 475                 480 


Asn Gly Ile Val His Val Ser Ala Lys Asp Lys Gly Thr Gly Arg Glu 
                485                 490                 495     


Gln Gln Ile Val Ile Gln Ser Ser Gly Gly Leu Ser Lys Asp Asp Ile 
            500                 505                 510         


Glu Asn Met Val Lys Asn Ala Glu Lys Tyr Ala Glu Glu Asp Arg Arg 
        515                 520                 525             


Lys Lys Glu Arg Val Glu Ala Val Asn Met Ala Glu Gly Ile Ile His 
    530                 535                 540                 


Asp Thr Glu Thr Lys Met Glu Glu Phe Lys Asp Gln Leu Pro Ala Asp 
545                 550                 555                 560 


Glu Cys Asn Lys Leu Lys Glu Glu Ile Ser Lys Met Arg Glu Leu Leu 
                565                 570                 575     


Ala Arg Lys Asp Ser Glu Thr Gly Glu Asn Ile Arg Gln Ala Ala Ser 
            580                 585                 590         


Ser Leu Gln Gln Ala Ser Leu Lys Leu Phe Glu Met Ala Tyr Lys Lys 
        595                 600                 605             


Met Ala Ser Glu Arg Glu Gly Ser Gly Ser Ser Gly Thr Gly Glu Gln 
    610                 615                 620                 


Lys Glu Asp Gln Lys Glu Glu Lys Gln 
625                 630             


<210>  39
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  40
<211>  732
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      


Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          


Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              


Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
    50                  55                  60                  


Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  


Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      


Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
            100                 105                 110         


Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
        115                 120                 125             


Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
    130                 135                 140                 


Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
145                 150                 155                 160 


Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                165                 170                 175     


Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
            180                 185                 190         


Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
        195                 200                 205             


Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
    210                 215                 220                 


Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp 
225                 230                 235                 240 


Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro 
                245                 250                 255     


Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 
            260                 265                 270         


Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu 
        275                 280                 285             


Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile 
    290                 295                 300                 


Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp 
305                 310                 315                 320 


Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu 
                325                 330                 335     


Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe 
            340                 345                 350         


Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val 
        355                 360                 365             


Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe 
    370                 375                 380                 


Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg 
385                 390                 395                 400 


Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu 
                405                 410                 415     


Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu 
            420                 425                 430         


Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly 
        435                 440                 445             


Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg 
    450                 455                 460                 


Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr 
465                 470                 475                 480 


Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly 
                485                 490                 495     


Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg 
            500                 505                 510         


Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr 
        515                 520                 525             


Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val 
    530                 535                 540                 


Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys 
545                 550                 555                 560 


Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu 
            580                 585                 590         


Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala 
        595                 600                 605             


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr 
    610                 615                 620                 


Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His 
625                 630                 635                 640 


Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp 
                645                 650                 655     


Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu 
            660                 665                 670         


Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile 
        675                 680                 685             


Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr 
    690                 695                 700                 


Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu 
705                 710                 715                 720 


Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                725                 730         


<210>  41
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Pro Cys Ser Gly Gly Asp Gly Ser Thr Pro Pro Gly Pro Ser 
1               5                   10                  15      


Leu Arg Asp Arg Asp Cys Pro Ala Gln Ser Ala Glu Tyr Pro Arg Asp 
            20                  25                  30          


Arg Leu Asp Pro Arg Pro Gly Ser Pro Ser Glu Ala Ser Ser Pro Pro 
        35                  40                  45              


Phe Leu Arg Ser Arg Ala Pro Val Asn Trp Tyr Gln Glu Lys Ala Gln 
    50                  55                  60                  


Val Phe Leu Trp His Leu Met Val Ser Gly Ser Thr Thr Leu Leu Cys 
65                  70                  75                  80  


Leu Trp Lys Gln Pro Phe His Val Ser Ala Phe Pro Val Thr Ala Ser 
                85                  90                  95      


Leu Ala Phe Arg Gln Ser Gln Gly Ala Gly Gln His Leu Tyr Lys Asp 
            100                 105                 110         


Leu Gln Pro Phe Ile Leu Leu Arg Leu Leu Met Pro Glu Glu Thr Gln 
        115                 120                 125             


Thr Gln Asp Gln Pro Met Glu Glu Glu Glu Val Glu Thr Phe Ala Phe 
    130                 135                 140                 


Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe Tyr 
145                 150                 155                 160 


Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ser Ser Asp 
                165                 170                 175     


Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys Leu 
            180                 185                 190         


Asp Ser Gly Lys Glu Leu His Ile Asn Leu Ile Pro Asn Lys Gln Asp 
        195                 200                 205             


Arg Thr Leu Thr Ile Val Asp Thr Gly Ile Gly Met Thr Lys Ala Asp 
    210                 215                 220                 


Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala Phe 
225                 230                 235                 240 


Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln Phe 
                245                 250                 255     


Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Thr Val 
            260                 265                 270         


Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser Ala 
        275                 280                 285             


Gly Gly Ser Phe Thr Val Arg Thr Asp Thr Gly Glu Pro Met Gly Arg 
    290                 295                 300                 


Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr Leu 
305                 310                 315                 320 


Glu Glu Arg Arg Ile Lys Glu Ile Val Lys Lys His Ser Gln Phe Ile 
                325                 330                 335     


Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys Glu Arg Asp Lys Glu Val 
            340                 345                 350         


Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys Glu 
        355                 360                 365             


Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro Glu Ile Glu Asp Val Gly 
    370                 375                 380                 


Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys Lys 
385                 390                 395                 400 


Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys 
                405                 410                 415     


Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly 
            420                 425                 430         


Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val 
        435                 440                 445             


Lys His Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe 
    450                 455                 460                 


Val Pro Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Arg Lys Lys Lys 
465                 470                 475                 480 


Asn Asn Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Asn Cys 
                485                 490                 495     


Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp 
            500                 505                 510         


Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser 
        515                 520                 525             


Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val Lys Lys Cys Leu Glu 
    530                 535                 540                 


Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr 
545                 550                 555                 560 


Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly Ile His Glu Asp Ser Gln 
                565                 570                 575     


Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg Tyr Tyr Thr Ser Ala Ser 
            580                 585                 590         


Gly Asp Glu Met Val Ser Leu Lys Asp Tyr Cys Thr Arg Met Lys Glu 
        595                 600                 605             


Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly Glu Thr Lys Asp Gln Val 
    610                 615                 620                 


Ala Asn Ser Ala Phe Val Glu Arg Leu Arg Lys His Gly Leu Glu Val 
625                 630                 635                 640 


Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys 
                645                 650                 655     


Glu Phe Glu Gly Lys Thr Leu Val Ser Val Thr Lys Glu Gly Leu Glu 
            660                 665                 670         


Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys Gln Glu Glu Lys Lys Thr 
        675                 680                 685             


Lys Phe Glu Asn Leu Cys Lys Ile Met Lys Asp Ile Leu Glu Lys Lys 
    690                 695                 700                 


Val Glu Lys Val Val Val Ser Asn Arg Leu Val Thr Ser Pro Cys Cys 
705                 710                 715                 720 


Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met 
                725                 730                 735     


Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Ala Ala 
            740                 745                 750         


Lys Lys His Leu Glu Ile Asn Pro Asp His Ser Ile Ile Glu Thr Leu 
        755                 760                 765             


Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp Lys Ser Val Lys Asp Leu 
    770                 775                 780                 


Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu 
785                 790                 795                 800 


Glu Asp Pro Gln Thr His Ala Asn Arg Ile Tyr Arg Met Ile Lys Leu 
                805                 810                 815     


Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr Ala Asp Asp Thr Ser Ala 
            820                 825                 830         


Ala Val Thr Glu Glu Met Pro Pro Leu Glu Gly Asp Asp Asp Thr Ser 
        835                 840                 845             


Arg Met Glu Glu Val Asp 
    850                 


<210>  42
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210>  43
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  44
<211>  801
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Arg Leu Trp Gly Leu Phe Gln Arg Ala Gln Gln Leu Ser Pro 
1               5                   10                  15      


Arg Ser Ser Gln Thr Val Tyr Gln Arg Val Glu Gly Pro Arg Lys Gly 
            20                  25                  30          


His Leu Glu Glu Glu Glu Glu Asp Gly Glu Glu Gly Ala Glu Thr Leu 
        35                  40                  45              


Ala His Phe Cys Pro Met Glu Leu Arg Gly Pro Glu Pro Leu Gly Ser 
    50                  55                  60                  


Arg Pro Arg Gln Pro Asn Leu Ile Pro Trp Ala Ala Ala Gly Arg Arg 
65                  70                  75                  80  


Ala Ala Pro Tyr Leu Val Leu Thr Ala Leu Leu Ile Phe Thr Gly Ala 
                85                  90                  95      


Phe Leu Leu Gly Tyr Val Ala Phe Arg Gly Ser Cys Gln Ala Cys Gly 
            100                 105                 110         


Asp Ser Val Leu Val Val Ser Glu Asp Val Asn Tyr Glu Pro Asp Leu 
        115                 120                 125             


Asp Phe His Gln Gly Arg Leu Tyr Trp Ser Asp Leu Gln Ala Met Phe 
    130                 135                 140                 


Leu Gln Phe Leu Gly Glu Gly Arg Leu Glu Asp Thr Ile Arg Gln Thr 
145                 150                 155                 160 


Ser Leu Arg Glu Arg Val Ala Gly Ser Ala Gly Met Ala Ala Leu Thr 
                165                 170                 175     


Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys Leu Asp His Val Trp 
            180                 185                 190         


Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro Asp Pro Ala His Pro 
        195                 200                 205             


Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys Val Gly Glu Gln Leu 
    210                 215                 220                 


Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr Ser Ala Ile Gly Asn 
225                 230                 235                 240 


Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly Arg Pro Glu Asp Leu 
                245                 250                 255     


Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val Gly Arg Leu Leu Leu 
            260                 265                 270         


Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys Val Thr Asn Ala Gln 
        275                 280                 285             


Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro Glu Pro Ala Asp Phe 
    290                 295                 300                 


Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser Gln Gln Ala Val Tyr 
305                 310                 315                 320 


Gly His Val His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro 
                325                 330                 335     


Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Ala Ser Ser Gly Leu Pro 
            340                 345                 350         


Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile Ala Ser Arg Leu Leu 
        355                 360                 365             


Arg Lys Leu Lys Gly Pro Val Ala Pro Gln Glu Trp Gln Gly Ser Leu 
    370                 375                 380                 


Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro Arg Leu Arg Leu Val 
385                 390                 395                 400 


Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn Asn Ile Phe Gly Cys 
                405                 410                 415     


Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val Val Ile Gly Ala Gln 
            420                 425                 430         


Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser Ala Val Gly Thr Ala 
        435                 440                 445             


Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser Met Val Ser Asn Gly 
    450                 455                 460                 


Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser Trp Asp Gly Gly Asp 
465                 470                 475                 480 


Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu Gly Tyr Leu Ser Val 
                485                 490                 495     


Leu His Leu Lys Ala Val Val Tyr Val Ser Leu Asp Asn Ala Val Leu 
            500                 505                 510         


Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro Leu Leu Thr Ser Leu 
        515                 520                 525             


Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro Asn His Ser Gly Gln 
    530                 535                 540                 


Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro Ser Trp Asp Ala Glu 
545                 550                 555                 560 


Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala Tyr Ser Phe Thr Ala 
                565                 570                 575     


Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe Met Glu Asp Asp Gln 
            580                 585                 590         


Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr Tyr Glu Asn Leu His 
        595                 600                 605             


Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala Gln Ala Val Ala Gln 
    610                 615                 620                 


Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His Asp Arg Leu Leu Pro 
625                 630                 635                 640 


Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu Arg His Ile Gly Asn 
                645                 650                 655     


Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg Gly Leu Thr Leu Gln 
            660                 665                 670         


Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg Ala Ala Glu Lys Leu 
        675                 680                 685             


Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp Glu Arg Leu Thr Arg 
    690                 695                 700                 


Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe Tyr Phe Leu Ser Gln 
705                 710                 715                 720 


Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His Ile Phe Met Gly Arg 
                725                 730                 735     


Gly Asp His Thr Leu Gly Ala Leu Leu Asp His Leu Arg Leu Leu Arg 
            740                 745                 750         


Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser Ser Thr Gly Phe Gln 
        755                 760                 765             


Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu Thr Trp Thr Leu Gln 
    770                 775                 780                 


Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp Asn Ile Asp Asn Asn 
785                 790                 795                 800 


Phe 
    


<210>  45
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Ala Leu Thr Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys 
1               5                   10                  15      


Leu Asp His Val Trp Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro 
            20                  25                  30          


Asp Pro Ala His Pro Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys 
        35                  40                  45              


Val Gly Glu Gln Leu Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr 
    50                  55                  60                  


Ser Ala Ile Gly Asn Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly 
65                  70                  75                  80  


Arg Pro Glu Asp Leu Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val 
                85                  90                  95      


Gly Arg Leu Leu Leu Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys 
            100                 105                 110         


Val Thr Asn Ala Gln Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro 
        115                 120                 125             


Glu Pro Ala Asp Phe Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser 
    130                 135                 140                 


Gln Gln Ala Val Tyr Gly His Val His Leu Gly Thr Gly Asp Pro Tyr 
145                 150                 155                 160 


Thr Pro Gly Phe Pro Ser Phe Asn Gln Thr Gln Phe Pro Pro Val Ala 
                165                 170                 175     


Ser Ser Gly Leu Pro Ser Ile Pro Ala Gln Pro Ile Ser Ala Asp Ile 
            180                 185                 190         


Ala Ser Arg Leu Leu Arg Lys Leu Lys Gly Pro Val Ala Pro Gln Glu 
        195                 200                 205             


Trp Gln Gly Ser Leu Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro 
    210                 215                 220                 


Arg Leu Arg Leu Val Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn 
225                 230                 235                 240 


Asn Ile Phe Gly Cys Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val 
                245                 250                 255     


Val Ile Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser 
            260                 265                 270         


Ala Val Gly Thr Ala Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser 
        275                 280                 285             


Met Val Ser Asn Gly Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser 
    290                 295                 300                 


Trp Asp Gly Gly Asp Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu 
305                 310                 315                 320 


Gly Tyr Leu Ser Val Leu His Leu Lys Ala Val Val Tyr Val Ser Leu 
                325                 330                 335     


Asp Asn Ala Val Leu Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro 
            340                 345                 350         


Leu Leu Thr Ser Leu Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro 
        355                 360                 365             


Asn His Ser Gly Gln Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro 
    370                 375                 380                 


Ser Trp Asp Ala Glu Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala 
385                 390                 395                 400 


Tyr Ser Phe Thr Ala Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe 
                405                 410                 415     


Met Glu Asp Asp Gln Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr 
            420                 425                 430         


Tyr Glu Asn Leu His Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala 
        435                 440                 445             


Gln Ala Val Ala Gln Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His 
    450                 455                 460                 


Asp Arg Leu Leu Pro Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu 
465                 470                 475                 480 


Arg His Ile Gly Asn Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg 
                485                 490                 495     


Gly Leu Thr Leu Gln Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg 
            500                 505                 510         


Ala Ala Glu Lys Leu Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp 
        515                 520                 525             


Glu Arg Leu Thr Arg Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe 
    530                 535                 540                 


Tyr Phe Leu Ser Gln Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His 
545                 550                 555                 560 


Ile Phe Met Gly Arg Gly Asp His Thr Leu Gly Ala Leu Leu Asp His 
                565                 570                 575     


Leu Arg Leu Leu Arg Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser 
            580                 585                 590         


Ser Thr Gly Phe Gln Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu 
        595                 600                 605             


Thr Trp Thr Leu Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp 
    610                 615                 620                 


Asn Ile Asp Asn Asn Phe 
625                 630 


<210>  46
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Glu Arg Leu Trp Gly Leu Phe Gln Arg Ala Gln Gln Leu Ser Pro 
1               5                   10                  15      


Arg Ser Ser Gln Thr Val Tyr Gln Arg Val Glu Gly Pro Arg Lys Gly 
            20                  25                  30          


His Leu Glu Glu Glu Glu Glu Asp Gly Glu Glu Gly Ala Glu Thr Leu 
        35                  40                  45              


Ala His Phe Cys Pro Met Glu Leu Arg Gly Pro Glu Pro Leu Gly Ser 
    50                  55                  60                  


Arg Pro Arg Gln Pro Asn Leu Ile Pro Trp Ala Ala Ala Gly Arg Arg 
65                  70                  75                  80  


Ala Ala Pro Tyr Leu Val Leu Thr Ala Leu Leu Ile Phe Thr Gly Ala 
                85                  90                  95      


Phe Leu Leu Gly Tyr Val Ala Phe Arg Gly Ser Cys Gln Ala Cys Gly 
            100                 105                 110         


Asp Ser Val Leu Val Val Ser Glu Asp Val Asn Tyr Glu Pro Asp Leu 
        115                 120                 125             


Asp Phe His Gln Gly Arg Leu Tyr Trp Ser Asp Leu Gln Ala Met Phe 
    130                 135                 140                 


Leu Gln Phe Leu Gly Glu Gly Arg Leu Glu Asp Thr Ile Arg Gln Thr 
145                 150                 155                 160 


Ser Leu Arg Glu Arg Val Ala Gly Ser Ala Gly Met Ala Ala Leu Thr 
                165                 170                 175     


Gln Asp Ile Arg Ala Ala Leu Ser Arg Gln Lys Leu Asp His Val Trp 
            180                 185                 190         


Thr Asp Thr His Tyr Val Gly Leu Gln Phe Pro Asp Pro Ala His Pro 
        195                 200                 205             


Asn Thr Leu His Trp Val Asp Glu Ala Gly Lys Val Gly Glu Gln Leu 
    210                 215                 220                 


Pro Leu Glu Asp Pro Asp Val Tyr Cys Pro Tyr Ser Ala Ile Gly Asn 
225                 230                 235                 240 


Val Thr Gly Glu Leu Val Tyr Ala His Tyr Gly Arg Pro Glu Asp Leu 
                245                 250                 255     


Gln Asp Leu Arg Ala Arg Gly Val Asp Pro Val Gly Arg Leu Leu Leu 
            260                 265                 270         


Val Arg Val Gly Val Ile Ser Phe Ala Gln Lys Val Thr Asn Ala Gln 
        275                 280                 285             


Asp Phe Gly Ala Gln Gly Val Leu Ile Tyr Pro Glu Pro Ala Asp Phe 
    290                 295                 300                 


Ser Gln Asp Pro Pro Lys Pro Ser Leu Ser Ser Gln Gln Ala Val Tyr 
305                 310                 315                 320 


Gly His Val His Leu Gly Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro 
                325                 330                 335     


Ser Phe Asn Gln Thr Gln Lys Leu Lys Gly Pro Val Ala Pro Gln Glu 
            340                 345                 350         


Trp Gln Gly Ser Leu Leu Gly Ser Pro Tyr His Leu Gly Pro Gly Pro 
        355                 360                 365             


Arg Leu Arg Leu Val Val Asn Asn His Arg Thr Ser Thr Pro Ile Asn 
    370                 375                 380                 


Asn Ile Phe Gly Cys Ile Glu Gly Arg Ser Glu Pro Asp His Tyr Val 
385                 390                 395                 400 


Val Ile Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala Ala Lys Ser 
                405                 410                 415     


Ala Val Gly Thr Ala Ile Leu Leu Glu Leu Val Arg Thr Phe Ser Ser 
            420                 425                 430         


Met Val Ser Asn Gly Phe Arg Pro Arg Arg Ser Leu Leu Phe Ile Ser 
        435                 440                 445             


Trp Asp Gly Gly Asp Phe Gly Ser Val Gly Ser Thr Glu Trp Leu Glu 
    450                 455                 460                 


Gly Tyr Leu Ser Val Leu His Leu Lys Ala Val Val Tyr Val Ser Leu 
465                 470                 475                 480 


Asp Asn Ala Val Leu Gly Asp Asp Lys Phe His Ala Lys Thr Ser Pro 
                485                 490                 495     


Leu Leu Thr Ser Leu Ile Glu Ser Val Leu Lys Gln Val Asp Ser Pro 
            500                 505                 510         


Asn His Ser Gly Gln Thr Leu Tyr Glu Gln Val Val Phe Thr Asn Pro 
        515                 520                 525             


Ser Trp Asp Ala Glu Val Ile Arg Pro Leu Pro Met Asp Ser Ser Ala 
    530                 535                 540                 


Tyr Ser Phe Thr Ala Phe Val Gly Val Pro Ala Val Glu Phe Ser Phe 
545                 550                 555                 560 


Met Glu Asp Asp Gln Ala Tyr Pro Phe Leu His Thr Lys Glu Asp Thr 
                565                 570                 575     


Tyr Glu Asn Leu His Lys Val Leu Gln Gly Arg Leu Pro Ala Val Ala 
            580                 585                 590         


Gln Ala Val Ala Gln Leu Ala Gly Gln Leu Leu Ile Arg Leu Ser His 
        595                 600                 605             


Asp Arg Leu Leu Pro Leu Asp Phe Gly Arg Tyr Gly Asp Val Val Leu 
    610                 615                 620                 


Arg His Ile Gly Asn Leu Asn Glu Phe Ser Gly Asp Leu Lys Ala Arg 
625                 630                 635                 640 


Gly Leu Thr Leu Gln Trp Val Tyr Ser Ala Arg Gly Asp Tyr Ile Arg 
                645                 650                 655     


Ala Ala Glu Lys Leu Arg Gln Glu Ile Tyr Ser Ser Glu Glu Arg Asp 
            660                 665                 670         


Glu Arg Leu Thr Arg Met Tyr Asn Val Arg Ile Met Arg Val Glu Phe 
        675                 680                 685             


Tyr Phe Leu Ser Gln Tyr Val Ser Pro Ala Asp Ser Pro Phe Arg His 
    690                 695                 700                 


Ile Phe Met Gly Arg Gly Asp His Thr Leu Gly Ala Leu Leu Asp His 
705                 710                 715                 720 


Leu Arg Leu Leu Arg Ser Asn Ser Ser Gly Thr Pro Gly Ala Thr Ser 
                725                 730                 735     


Ser Thr Gly Phe Gln Glu Ser Arg Phe Arg Arg Gln Leu Ala Leu Leu 
            740                 745                 750         


Thr Trp Thr Leu Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp Val Trp 
        755                 760                 765             


Asn Ile Asp Asn Asn Phe 
    770                 


<210>  47
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  48
<211>  1066
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Arg 
        115                 120                 125             


Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn Ser Glu Gly Val 
    130                 135                 140                 


Val Pro Ala Ser Tyr Asp Ser Arg Gln Gly Phe Asn Gly Thr Phe Thr 
145                 150                 155                 160 


Val Gly Pro Tyr Ile Cys Glu Ala Thr Val Lys Gly Lys Lys Phe Gln 
                165                 170                 175     


Thr Ile Pro Phe Asn Val Tyr Ala Leu Lys Ala Thr Ser Glu Leu Asp 
            180                 185                 190         


Leu Glu Met Glu Ala Leu Lys Thr Val Tyr Lys Ser Gly Glu Thr Ile 
        195                 200                 205             


Val Val Thr Cys Ala Val Phe Asn Asn Glu Val Val Asp Leu Gln Trp 
    210                 215                 220                 


Thr Tyr Pro Gly Glu Val Lys Gly Lys Gly Ile Thr Met Leu Glu Glu 
225                 230                 235                 240 


Ile Lys Val Pro Ser Ile Lys Leu Val Tyr Thr Leu Thr Val Pro Glu 
                245                 250                 255     


Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu Cys Ala Ala Arg Gln Ala 
            260                 265                 270         


Thr Arg Glu Val Lys Glu Met Lys Lys Val Thr Ile Ser Val His Glu 
        275                 280                 285             


Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val 
    290                 295                 300                 


Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg Ala Tyr Pro 
305                 310                 315                 320 


Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn 
                325                 330                 335     


Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu Ile Arg Tyr 
            340                 345                 350         


Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His 
        355                 360                 365             


Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe 
    370                 375                 380                 


Glu Leu Leu Thr Gln Val Pro Ser Ser Ile Leu Asp Leu Val Asp Asp 
385                 390                 395                 400 


His His Gly Ser Thr Gly Gly Gln Thr Val Arg Cys Thr Ala Glu Gly 
                405                 410                 415     


Thr Pro Leu Pro Asp Ile Glu Trp Met Ile Cys Lys Asp Ile Lys Lys 
            420                 425                 430         


Cys Asn Asn Glu Thr Ser Trp Thr Ile Leu Ala Asn Asn Val Ser Asn 
        435                 440                 445             


Ile Ile Thr Glu Ile His Ser Arg Asp Arg Ser Thr Val Glu Gly Arg 
    450                 455                 460                 


Val Thr Phe Ala Lys Val Glu Glu Thr Ile Ala Val Arg Cys Leu Ala 
465                 470                 475                 480 


Lys Asn Leu Leu Gly Ala Glu Asn Arg Glu Leu Lys Leu Val Ala Pro 
                485                 490                 495     


Thr Leu Arg Ser Glu Leu Thr Val Ala Ala Ala Val Leu Val Leu Leu 
            500                 505                 510         


Val Ile Val Ile Ile Ser Leu Ile Val Leu Val Val Ile Trp Lys Gln 
        515                 520                 525             


Lys Pro Arg Tyr Glu Ile Arg Trp Arg Val Ile Glu Ser Ile Ser Pro 
    530                 535                 540                 


Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp 
545                 550                 555                 560 


Ser Arg Trp Glu Phe Pro Arg Asp Gly Leu Val Leu Gly Arg Val Leu 
                565                 570                 575     


Gly Ser Gly Ala Phe Gly Lys Val Val Glu Gly Thr Ala Tyr Gly Leu 
            580                 585                 590         


Ser Arg Ser Gln Pro Val Met Lys Val Ala Val Lys Met Leu Lys Pro 
        595                 600                 605             


Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile 
    610                 615                 620                 


Met Thr His Leu Gly Pro His Leu Asn Ile Val Asn Leu Leu Gly Ala 
625                 630                 635                 640 


Cys Thr Lys Ser Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Phe Tyr 
                645                 650                 655     


Gly Asp Leu Val Asn Tyr Leu His Lys Asn Arg Asp Ser Phe Leu Ser 
            660                 665                 670         


His His Pro Glu Lys Pro Lys Lys Glu Leu Asp Ile Phe Gly Leu Asn 
        675                 680                 685             


Pro Ala Asp Glu Ser Thr Arg Ser Tyr Val Ile Leu Ser Phe Glu Asn 
    690                 695                 700                 


Asn Gly Asp Tyr Met Asp Met Lys Gln Ala Asp Thr Thr Gln Tyr Val 
705                 710                 715                 720 


Pro Met Leu Glu Arg Lys Glu Val Ser Lys Tyr Ser Asp Ile Gln Arg 
                725                 730                 735     


Ser Leu Tyr Asp Arg Pro Ala Ser Tyr Lys Lys Lys Ser Met Leu Asp 
            740                 745                 750         


Ser Glu Val Lys Asn Leu Leu Ser Asp Asp Asn Ser Glu Gly Leu Thr 
        755                 760                 765             


Leu Leu Asp Leu Leu Ser Phe Thr Tyr Gln Val Ala Arg Gly Met Glu 
    770                 775                 780                 


Phe Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn 
785                 790                 795                 800 


Val Leu Leu Ala Gln Gly Lys Ile Val Lys Ile Cys Asp Phe Gly Leu 
                805                 810                 815     


Ala Arg Asp Ile Met His Asp Ser Asn Tyr Val Ser Lys Gly Ser Thr 
            820                 825                 830         


Phe Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Asn Leu 
        835                 840                 845             


Tyr Thr Thr Leu Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
    850                 855                 860                 


Ile Phe Ser Leu Gly Gly Thr Pro Tyr Pro Gly Met Met Val Asp Ser 
865                 870                 875                 880 


Thr Phe Tyr Asn Lys Ile Lys Ser Gly Tyr Arg Met Ala Lys Pro Asp 
                885                 890                 895     


His Ala Thr Ser Glu Val Tyr Glu Ile Met Val Lys Cys Trp Asn Ser 
            900                 905                 910         


Glu Pro Glu Lys Arg Pro Ser Phe Tyr His Leu Ser Glu Ile Val Glu 
        915                 920                 925             


Asn Leu Leu Pro Gly Gln Tyr Lys Lys Ser Tyr Glu Lys Ile His Leu 
    930                 935                 940                 


Asp Phe Leu Lys Ser Asp His Pro Ala Val Ala Arg Met Arg Val Asp 
945                 950                 955                 960 


Ser Asp Asn Ala Tyr Ile Gly Val Thr Tyr Lys Asn Glu Glu Asp Lys 
                965                 970                 975     


Leu Lys Asp Trp Glu Gly Gly Leu Asp Glu Gln Arg Leu Ser Ala Asp 
            980                 985                 990         


Ser Gly Tyr Ile Ile Pro Leu Pro  Asp Ile Asp Pro Val  Pro Glu Glu 
        995                 1000                 1005             


Glu Asp  Leu Gly Lys Arg Asn  Arg His Ser Ser Gln  Thr Ser Glu 
    1010                 1015                 1020             


Glu Ser  Ala Ile Glu Thr Gly  Ser Ser Ser Ser Thr  Phe Ile Lys 
    1025                 1030                 1035             


Arg Glu  Asp Glu Thr Ile Glu  Asp Ile Asp Met Met  Asp Asp Ile 
    1040                 1045                 1050             


Gly Ile  Asp Ser Ser Asp Leu  Val Glu Asp Ser Phe  Leu 
    1055                 1060                 1065     


<210>  49
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Arg 
        115                 120                 125             


Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn Ser Glu Gly Val 
    130                 135                 140                 


Val Pro Ala Ser Tyr Asp Ser Arg Gln Gly Phe Asn Gly Thr Phe Thr 
145                 150                 155                 160 


Val Gly Pro Tyr Ile Cys Glu Ala Thr Val Lys Gly Lys Lys Phe Gln 
                165                 170                 175     


Thr Ile Pro Phe Asn Val Tyr Ala Leu Lys Ala Thr Ser Glu Leu Asp 
            180                 185                 190         


Leu Glu Met Glu Ala Leu Lys Thr Val Tyr Lys Ser Gly Glu Thr Ile 
        195                 200                 205             


Val Val Thr Cys Ala Val Phe Asn Asn Glu Val Val Asp Leu Gln Trp 
    210                 215                 220                 


Thr Tyr Pro Gly Glu Val Lys Gly Lys Gly Ile Thr Met Leu Glu Glu 
225                 230                 235                 240 


Ile Lys Val Pro Ser Ile Lys Leu Val Tyr Thr Leu Thr Val Pro Glu 
                245                 250                 255     


Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu Cys Ala Ala Arg Gln Ala 
            260                 265                 270         


Thr Arg Glu Val Lys Glu Met Lys Lys Val Thr Ile Ser Val His Glu 
        275                 280                 285             


Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val 
    290                 295                 300                 


Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg Ala Tyr Pro 
305                 310                 315                 320 


Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn 
                325                 330                 335     


Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu Ile Arg Tyr 
            340                 345                 350         


Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His 
        355                 360                 365             


Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe 
    370                 375                 380                 


Glu Leu Leu Thr Gln Val Pro Ser Ser Ile Leu Asp Leu Val Asp Asp 
385                 390                 395                 400 


His His Gly Ser Thr Gly Gly Gln Thr Val Arg Cys Thr Ala Glu Gly 
                405                 410                 415     


Thr Pro Leu Pro Asp Ile Glu Trp Met Ile Cys Lys Asp Ile Lys Lys 
            420                 425                 430         


Cys Asn Asn Glu Thr Ser Trp Thr Ile Leu Ala Asn Asn Val Ser Asn 
        435                 440                 445             


Ile Ile Thr Glu Ile His Ser Arg Asp Arg Ser Thr Val Glu Gly Arg 
    450                 455                 460                 


Val Thr Phe Ala Lys Val Glu Glu Thr Ile Ala Val Arg Cys Leu Ala 
465                 470                 475                 480 


Lys Asn Leu Leu Gly Ala Glu Asn Arg Glu Leu Lys Leu Val Ala Pro 
                485                 490                 495     


Thr Leu Arg Ser Glu Leu Thr Val Ala 
            500                 505 


<210>  50
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Gly Thr Cys Ile Ile Ser Phe Leu Leu 
    210                 215             


<210>  51
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  51

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Arg 
        115                 120                 125             


Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn Ser Glu Gly Val 
    130                 135                 140                 


Val Pro Ala Ser Tyr Asp Ser Arg Gln Gly Phe Asn Gly Thr Phe Thr 
145                 150                 155                 160 


Val Gly Pro Tyr Ile Cys Glu Ala Thr Val Lys Gly Lys Lys Phe Gln 
                165                 170                 175     


Thr Ile Pro Phe Asn Val Tyr Ala Leu Lys Gly Thr Cys Ile Ile Ser 
            180                 185                 190         


Phe Leu Leu 
        195 


<210>  52
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Ser 
705                 710                 715                 720 


Gly Gln Gly Cys Leu Ser Ser Gly Thr Leu Gln Glu Leu Ser Val Asp 
                725                 730                 735     


Leu Gln Ala Arg Gly Pro Cys 
            740             


<210>  53
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Leu Ser Leu Pro Ser Ile Leu Pro Asn Glu Asn Glu Lys Val Val 
1               5                   10                  15      


Gln Leu Asn Ser Ser Phe Ser Leu Arg Cys Phe Gly Glu Ser Glu Val 
            20                  25                  30          


Ser Trp Gln Tyr Pro Met Ser Glu Glu Glu Ser Ser Asp Val Glu Ile 
        35                  40                  45              


Arg Asn Glu Glu Asn Asn Ser Gly Leu Phe Val Thr Val Leu Glu Val 
    50                  55                  60                  


Ser Ser Ala Ser Ala Ala His Thr Gly Leu Tyr Thr Cys Tyr Tyr Asn 
65                  70                  75                  80  


His Thr Gln Thr Glu Glu Asn Glu Leu Glu Gly Arg His Ile Tyr Ile 
                85                  90                  95      


Tyr Val Pro Asp Pro Asp Val Ala Phe Val Pro Leu Gly Met Thr Asp 
            100                 105                 110         


Tyr Leu Val Ile Val Glu Asp Asp Asp Ser Ala Ile Ile Pro Cys Arg 
        115                 120                 125             


Thr Thr Asp Pro Glu Thr Pro Val Thr Leu His Asn Ser Glu Gly Val 
    130                 135                 140                 


Val Pro Ala Ser Tyr Asp Ser Arg Gln Gly Phe Asn Gly Thr Phe Thr 
145                 150                 155                 160 


Val Gly Pro Tyr Ile Cys Glu Ala Thr Val Lys Gly Lys Lys Phe Gln 
                165                 170                 175     


Thr Ile Pro Phe Asn Val Tyr Ala Leu Lys Ala Thr Ser Glu Leu Asp 
            180                 185                 190         


Leu Glu Met Glu Ala Leu Lys Thr Val Tyr Lys Ser Gly Glu Thr Ile 
        195                 200                 205             


Val Val Thr Cys Ala Val Phe Asn Asn Glu Val Val Asp Leu Gln Trp 
    210                 215                 220                 


Thr Tyr Pro Gly Glu Val Lys Gly Lys Gly Ile Thr Met Leu Glu Glu 
225                 230                 235                 240 


Ile Lys Val Pro Ser Ile Lys Leu Val Tyr Thr Leu Thr Val Pro Glu 
                245                 250                 255     


Ala Thr Val Lys Asp Ser Gly Asp Tyr Glu Cys Ala Ala Arg Gln Ala 
            260                 265                 270         


Thr Arg Glu Val Lys Glu Met Lys Lys Val Thr Ile Ser Val His Glu 
        275                 280                 285             


Lys Gly Phe Ile Glu Ile Lys Pro Thr Phe Ser Gln Leu Glu Ala Val 
    290                 295                 300                 


Asn Leu His Glu Val Lys His Phe Val Val Glu Val Arg Ala Tyr Pro 
305                 310                 315                 320 


Pro Pro Arg Ile Ser Trp Leu Lys Asn Asn Leu Thr Leu Ile Glu Asn 
                325                 330                 335     


Leu Thr Glu Ile Thr Thr Asp Val Glu Lys Ile Gln Glu Ile Arg Tyr 
            340                 345                 350         


Arg Ser Lys Leu Lys Leu Ile Arg Ala Lys Glu Glu Asp Ser Gly His 
        355                 360                 365             


Tyr Thr Ile Val Ala Gln Asn Glu Asp Ala Val Lys Ser Tyr Thr Phe 
    370                 375                 380                 


Glu Leu Leu Thr Gln Val Pro Ser Ser Ile Leu Asp Leu Val Asp Asp 
385                 390                 395                 400 


His His Gly Ser Thr Gly Gly Gln Thr Val Arg Cys Thr Ala Glu Gly 
                405                 410                 415     


Thr Pro Leu Pro Asp Ile Glu Trp Met Ile Cys Lys Asp Ile Lys Lys 
            420                 425                 430         


Cys Asn Asn Glu Thr Ser Trp Thr Ile Leu Ala Asn Asn Val Ser Asn 
        435                 440                 445             


Ile Ile Thr Glu Ile His Ser Arg Asp Arg Ser Thr Val Glu Gly Arg 
    450                 455                 460                 


Val Thr Phe Ala Lys Val Glu Glu Thr Ile Ala Val Arg Cys Leu Ala 
465                 470                 475                 480 


Lys Asn Leu Leu Gly Ala Glu Asn Arg Glu Leu Lys Leu Val Ala Pro 
                485                 490                 495     


Thr Leu Arg Ser Glu Leu Thr Val Ala Ala Ala Val Leu Val Leu Leu 
            500                 505                 510         


Val Ile Val Ile Ile Ser Leu Ile Val Leu Val Val Ile Trp Lys Gln 
        515                 520                 525             


Lys Pro Arg Tyr Glu Ile Arg Trp Arg Val Ile Glu Ser Ile Ser Pro 
    530                 535                 540                 


Asp Gly His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp 
545                 550                 555                 560 


Ser Arg Trp Glu Phe Pro Arg Asp Gly Leu Val Leu Gly Arg Val Leu 
                565                 570                 575     


Gly Ser Gly Ala Phe Gly Lys Val Val Glu Gly Thr Ala Tyr Gly Leu 
            580                 585                 590         


Ser Arg Ser Gln Pro Val Met Lys Val Ala Val Lys Met Leu Lys Pro 
        595                 600                 605             


Thr Ala Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile 
    610                 615                 620                 


Met Thr His Leu Gly Pro His Leu Asn Ile Val Asn Leu Leu Gly Ala 
625                 630                 635                 640 


Cys Thr Lys Ser Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Phe Tyr 
                645                 650                 655     


Gly Asp Leu Val Asn Tyr Leu His Lys Asn Arg Asp Ser Phe Leu Ser 
            660                 665                 670         


His His Pro Glu Lys Pro Lys Lys Glu Leu Asp Ile Phe Gly Leu Asn 
        675                 680                 685             


Pro Ala Asp Glu Ser Thr Arg Ser Ser Gly Gln Gly Cys Leu Ser Ser 
    690                 695                 700                 


Gly Thr Leu Gln Glu Leu Ser Val Asp Leu Gln Ala Arg Gly Pro Cys 
705                 710                 715                 720 


<210>  54
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  55
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  55

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Val Met Ser Val Ala Thr Ile Val 
            100                 105                 110         


Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu Leu Leu Val Tyr Tyr 
        115                 120                 125             


Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala 
    130                 135                 140                 


Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro 
145                 150                 155                 160 


Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu 
                165                 170                 175     


Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
            180                 185 


<210>  56
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  56

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp 
            100                 


<210>  57
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  58
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  58
agacaagaau aaacgcucaa aguug                                             25


<210>  59
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  59
uuuauucaca uuuuugaauu ga                                                22


<210>  60
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Leu His Asn His His Pro Ile Lys Pro Phe Ile Thr Ser Asn Asn 
1               5                   10                  15      


Ser Asn Pro Val Glu Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro 
            20                  25                  30          


Glu Ile Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu 
        35                  40                  45              


Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr 
    50                  55                  60                  


Leu Leu Ser Val Thr Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile 
65                  70                  75                  80  


Gln Asn Glu Leu Ser Val Asp His Ser Asp Pro Val Ile Leu Asn Val 
                85                  90                  95      


Leu Tyr Gly Pro Asp Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr 
            100                 105                 110         


Arg Pro Gly Val Asn Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro 
        115                 120                 125             


Pro Ala Gln Tyr Ser Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr 
    130                 135                 140                 


Gln Glu Leu Phe Ile Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr 
145                 150                 155                 160 


Thr Cys Gln Ala Asn Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val 
                165                 170                 175     


Lys Thr Ile Thr Val Ser Ala Asp Val Pro Lys Pro Ser Ile Ser Ser 
            180                 185                 190         


Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala Val Ala Phe His Cys 
        195                 200                 205             


Glu Pro Glu Ala Gln Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln 
    210                 215                 220                 


Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr 
225                 230                 235                 240 


Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys 
                245                 250                 255     


Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu 
            260                 265                 270         


Asp Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile Ser Pro Pro Pro 
        275                 280                 285         


<210>  61
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Truncated CD3e3

<400>  61
guucguagcg auuuaacugc gucagc                                            26


