                         SEQUENCE LISTING

<110>  Friedman, Harvey
       Weismann, Drew
       Awasthi, Sita
 
<120>  MODIFIED MRNA VACCINES ENCODING HERPES SIMPLEX VIRUS 
       GLYCOPROTEINS AND USES THEREOF

<130>  P-572137-PC

<150>  62/546,648
<151>  2017-08-17

<150>  62/701,019
<151>  2017-07-20

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein D from Herpes Simplex Virus-1

<400>  1
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaugcgcau gcagcugcug cugcugaucg cccugucccu      180

ggcccuggug accaacucca aguacgcccu ggccgacgcc ucccugaaga uggccgaccc      240

caaccgcuuc cgcggcaagg accugcccgu gcuggaccag cugaccgacc cccccggcgu      300

gcgccgcgug uaccacaucc aggccggccu gcccgacccc uuccagcccc ccucccugcc      360

caucaccgug uacuacgccg ugcuggagcg cgccugccgc uccgugcugc ugaacgcccc      420

cuccgaggcc ccccagaucg ugcgcggcgc cuccgaggac gugcgcaagc agcccuacaa      480

ccugaccauc gccugguucc gcaugggcgg caacugcgcc auccccauca ccgugaugga      540

guacaccgag ugcuccuaca acaagucccu gggcgccugc cccauccgca cccagccccg      600

cuggaacuac uacgacuccu ucuccgccgu guccgaggac aaccugggcu uccugaugca      660

cgcccccgcc uucgagaccg ccggcaccua ccugcgccug gugaagauca acgacuggac      720

cgagaucacc caguucaucc uggagcaccg cgccaagggc uccugcaagu acgcccugcc      780

ccugcgcauc ccccccuccg ccugccuguc cccccaggcc uaccagcagg gcgugaccgu      840

ggacuccauc ggcaugcugc cccgcuucau ccccgagaac cagcgcaccg uggccgugua      900

cucccugaag aucgccggcu ggcacggccc caaggccccc uacaccucca cccugcugcc      960

ccccgagcug uccgagaccc ccaacgccac ccagcccgag cuggcccccg aggaccccga     1020

ggacuccgcc cugcuggagg accccguggg caccguggcc ccccagaucc cccccaacug     1080

gcacaucccc uccauccagg acgccgccac ccccuacuaa cuaguaguga cugacuagga     1140

ucugguuacc acuaaaccag ccucaagaac acccgaaugg agucucuaag cuacauaaua     1200

ccaacuuaca cuuacaaaau guuguccccc aaaauguagc cauucguauc ugcuccuaau     1260

aaaaagaaag uuucuucaca uucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaac                                                                1386


<210>  2
<211>  306
<212>  PRT
<213>  Human alphaherpesvirus 1

<400>  2

Lys Tyr Ala Leu Ala Asp Ala Ser Leu Lys Met Ala Asp Pro Asn Arg 
1               5                   10                  15      


Phe Arg Gly Lys Asp Leu Pro Val Leu Asp Gln Leu Thr Asp Pro Pro 
            20                  25                  30          


Gly Val Arg Arg Val Tyr His Ile Gln Ala Gly Leu Pro Asp Pro Phe 
        35                  40                  45              


Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg 
    50                  55                  60                  


Ala Cys Arg Ser Val Leu Leu Asn Ala Pro Ser Glu Ala Pro Gln Ile 
65                  70                  75                  80  


Val Arg Gly Ala Ser Glu Asp Val Arg Lys Gln Pro Tyr Asn Leu Thr 
                85                  90                  95      


Ile Ala Trp Phe Arg Met Gly Gly Asn Cys Ala Ile Pro Ile Thr Val 
            100                 105                 110         


Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys Ser Leu Gly Ala Cys Pro 
        115                 120                 125             


Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr Asp Ser Phe Ser Ala Val 
    130                 135                 140                 


Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr 
145                 150                 155                 160 


Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile 
                165                 170                 175     


Thr Gln Phe Ile Leu Glu His Arg Ala Lys Gly Ser Cys Lys Tyr Ala 
            180                 185                 190         


Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys Leu Ser Pro Gln Ala Tyr 
        195                 200                 205             


Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile 
    210                 215                 220                 


Pro Glu Asn Gln Arg Thr Val Ala Val Tyr Ser Leu Lys Ile Ala Gly 
225                 230                 235                 240 


Trp His Gly Pro Lys Ala Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu 
                245                 250                 255     


Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro Glu Leu Ala Pro Glu Asp 
            260                 265                 270         


Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Val Gly Thr Val Ala Pro 
        275                 280                 285             


Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Ala Ala Thr 
    290                 295                 300                 


Pro Tyr 
305     


<210>  3
<211>  394
<212>  PRT
<213>  Human alphaherpesvirus 1

<400>  3

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Leu Ala Asp Pro Asn Arg Phe Arg Arg Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp 
            100                 105                 110         


Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly 
        115                 120                 125             


Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Ala Pro Glu Ala Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr 
                325                 330                 335     


Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu 
            340                 345                 350         


Ala Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr 
        355                 360                 365             


Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp 
    370                 375                 380                 


Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
385                 390                 


<210>  4
<211>  1386
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein D from Herpes Simplex Virus-2

<400>  4
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaugacccg ccugaccgug cuggcccugc uggccggccu      180

gcuggccucc ucccgcgcca aguacgcccu ggccgacccc ucccugaaga uggccgaccc      240

caaccgcuuc cgcggcaaga accugcccgu gcuggaccag cugaccgacc cccccggcgu      300

gaagcgcgug uaccacaucc agcccucccu ggaggacccc uuccagcccc ccuccauccc      360

caucaccgug uacuacgccg ugcuggagcg cgccugccgc uccgugcugc ugcacgcccc      420

cuccgaggcc ccccagaucg ugcgcggcgc cuccgacgag gcccgcaagc acaccuacaa      480

ccugaccauc gccugguacc gcaugggcga caacugcgcc auccccauca ccgugaugga      540

guacaccgag ugccccuaca acaagucccu gggcgugugc cccauccgca cccagccccg      600

cugguccuac uacgacuccu ucuccgccgu guccgaggac aaccugggcu uccugaugca      660

cgcccccgcc uucgagaccg ccggcaccua ccugcgccug gugaagauca acgacuggac      720

cgagaucacc caguucaucc uggagcaccg cgcccgcgcc uccugcaagu acgcccugcc      780

ccugcgcauc ccccccgccg ccugccugac cuccaaggcc uaccagcagg gcgugaccgu      840

ggacuccauc ggcaugcugc cccgcuucau ccccgagaac cagcgcaccg uggcccugua      900

cucccugaag aucgccggcu ggcacggccc caagcccccc uacaccucca cccugcugcc      960

ccccgagcug uccgacacca ccaacgccac ccagcccgag cuggugcccg aggaccccga     1020

ggacuccgcc cugcuggagg accccgccgg caccgugucc ucccagaucc cccccaacug     1080

gcacaucccc uccauccagg acguggcccc ccaccacuaa cuaguaguga cugacuagga     1140

ucugguuacc acuaaaccag ccucaagaac acccgaaugg agucucuaag cuacauaaua     1200

ccaacuuaca cuuacaaaau guuguccccc aaaauguagc cauucguauc ugcuccuaau     1260

aaaaagaaag uuucuucaca uucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1380

aaaaac                                                                1386


<210>  5
<211>  306
<212>  PRT
<213>  Human alphaherpesvirus 2

<400>  5

Lys Tyr Ala Leu Ala Asp Pro Ser Leu Lys Met Ala Asp Pro Asn Arg 
1               5                   10                  15      


Phe Arg Gly Lys Asn Leu Pro Val Leu Asp Gln Leu Thr Asp Pro Pro 
            20                  25                  30          


Gly Val Lys Arg Val Tyr His Ile Gln Pro Ser Leu Glu Asp Pro Phe 
        35                  40                  45              


Gln Pro Pro Ser Ile Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg 
    50                  55                  60                  


Ala Cys Arg Ser Val Leu Leu His Ala Pro Ser Glu Ala Pro Gln Ile 
65                  70                  75                  80  


Val Arg Gly Ala Ser Asp Glu Ala Arg Lys His Thr Tyr Asn Leu Thr 
                85                  90                  95      


Ile Ala Trp Tyr Arg Met Gly Asp Asn Cys Ala Ile Pro Ile Thr Val 
            100                 105                 110         


Met Glu Tyr Thr Glu Cys Pro Tyr Asn Lys Ser Leu Gly Val Cys Pro 
        115                 120                 125             


Ile Arg Thr Gln Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser Ala Val 
    130                 135                 140                 


Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr 
145                 150                 155                 160 


Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile 
                165                 170                 175     


Thr Gln Phe Ile Leu Glu His Arg Ala Arg Ala Ser Cys Lys Tyr Ala 
            180                 185                 190         


Leu Pro Leu Arg Ile Pro Pro Ala Ala Cys Leu Thr Ser Lys Ala Tyr 
        195                 200                 205             


Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile 
    210                 215                 220                 


Pro Glu Asn Gln Arg Thr Val Ala Leu Tyr Ser Leu Lys Ile Ala Gly 
225                 230                 235                 240 


Trp His Gly Pro Lys Pro Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu 
                245                 250                 255     


Leu Ser Asp Thr Thr Asn Ala Thr Gln Pro Glu Leu Val Pro Glu Asp 
            260                 265                 270         


Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Ala Gly Thr Val Ser Ser 
        275                 280                 285             


Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Val Ala Pro 
    290                 295                 300                 


His His 
305     


<210>  6
<211>  393
<212>  PRT
<213>  Human alphaherpesvirus 2

<400>  6

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 
1               5                   10                  15      


Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 
            100                 105                 110         


Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 
        115                 120                 125             


Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 
                325                 330                 335     


Ser Asn Pro Gly Leu Ile Ile Gly Ala Leu Ala Gly Ser Thr Leu Ala 
            340                 345                 350         


Val Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gln 
        355                 360                 365             


Met Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala 
    370                 375                 380                 


Pro Pro Ser His Gln Pro Leu Phe Tyr 
385                 390             


<210>  7
<211>  1779
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein C from Herpes Simplex Virus-1

<400>  7
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcauggccau cuccggcgug cccgugcugg gcuucuucau      180

caucgccgug cugauguccg cccaggaguc cugggccgag accgccucca ccggccccac      240

caucaccgcc ggcgccguga ccaacgccuc cgaggccccc accuccggcu cccccggcuc      300

cgccgccucc cccgagguga cccccaccuc cacccccaac cccaacaacg ugacccagaa      360

caagaccacc cccaccgagc ccgccucccc ccccaccacc cccaagccca ccuccacccc      420

caaguccccc cccaccucca cccccgaccc caagcccaag aacaacacca cccccgccaa      480

guccggccgc cccaccaagc cccccggccc cguguggugc gaccgccgcg acccccuggc      540

ccgcuacggc ucccgcgugc agauccgcug ccgcuuccgc aacuccaccc gcauggaguu      600

ccgccugcag aucuggcgcu acuccauggg ccccuccccc cccaucgccc ccgcccccga      660

ccuggaggag gugcugacca acaucaccgc cccccccggc ggccugcugg uguacgacuc      720

cgcccccaac cugaccgacc cccacgugcu gugggccgag ggcgccggcc ccggcgccga      780

ccccccccug uacuccguga ccggcccccu gcccacccag cgccugauca ucggcgaggu      840

gacccccgcc acccagggca uguacuaccu ggccuggggc cgcauggacu ccccccacga      900

guacggcacc ugggugcgcg ugcgcauguu ccgccccccc ucccugaccc ugcagcccca      960

cgccgugaug gagggccagc ccuucaaggc caccugcacc gccgccgccu acuacccccg     1020

caaccccgug gaguucgacu gguucgagga cgaccgccag guguucaacc ccggccagau     1080

cgacacccag acccacgagc accccgacgg cuucaccacc guguccaccg ugaccuccga     1140

ggccgugggc ggccaggugc ccccccgcac cuucaccugc cagaugaccu ggcaccgcga     1200

cuccgugacc uucucccgcc gcaacgccac cggccuggcc cuggugcugc cccgccccac     1260

caucaccaug gaguucggcg ugcgccacgu ggugugcacc gccggcugcg ugcccgaggg     1320

cgugaccuuc gccugguucc ugggcgacga ccccuccccc gccgccaagu ccgccgugac     1380

cgcccaggag uccugcgacc accccggccu ggccaccgug cgcuccaccc ugcccaucuc     1440

cuacgacuac uccgaguaca ucugccgccu gaccggcuac cccgccggca uccccgugcu     1500

ggagcaccac uaacuaguag ugacugacua ggaucugguu accacuaaac cagccucaag     1560

aacacccgaa uggagucucu aagcuacaua auaccaacuu acacuuacaa aauguugucc     1620

cccaaaaugu agccauucgu aucugcuccu aauaaaaaga aaguuucuuc acauucuaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaac                            1779


<210>  8
<211>  431
<212>  PRT
<213>  Human alphaherpesvirus 1

<400>  8

Glu Thr Ala Ser Thr Gly Pro Thr Ile Thr Ala Gly Ala Val Thr Asn 
1               5                   10                  15      


Ala Ser Glu Ala Pro Thr Ser Gly Ser Pro Gly Ser Ala Ala Ser Pro 
            20                  25                  30          


Glu Val Thr Pro Thr Ser Thr Pro Asn Pro Asn Asn Val Thr Gln Asn 
        35                  40                  45              


Lys Thr Thr Pro Thr Glu Pro Ala Ser Pro Pro Thr Thr Pro Lys Pro 
    50                  55                  60                  


Thr Ser Thr Pro Lys Ser Pro Pro Thr Ser Thr Pro Asp Pro Lys Pro 
65                  70                  75                  80  


Lys Asn Asn Thr Thr Pro Ala Lys Ser Gly Arg Pro Thr Lys Pro Pro 
                85                  90                  95      


Gly Pro Val Trp Cys Asp Arg Arg Asp Pro Leu Ala Arg Tyr Gly Ser 
            100                 105                 110         


Arg Val Gln Ile Arg Cys Arg Phe Arg Asn Ser Thr Arg Met Glu Phe 
        115                 120                 125             


Arg Leu Gln Ile Trp Arg Tyr Ser Met Gly Pro Ser Pro Pro Ile Ala 
    130                 135                 140                 


Pro Ala Pro Asp Leu Glu Glu Val Leu Thr Asn Ile Thr Ala Pro Pro 
145                 150                 155                 160 


Gly Gly Leu Leu Val Tyr Asp Ser Ala Pro Asn Leu Thr Asp Pro His 
                165                 170                 175     


Val Leu Trp Ala Glu Gly Ala Gly Pro Gly Ala Asp Pro Pro Leu Tyr 
            180                 185                 190         


Ser Val Thr Gly Pro Leu Pro Thr Gln Arg Leu Ile Ile Gly Glu Val 
        195                 200                 205             


Thr Pro Ala Thr Gln Gly Met Tyr Tyr Leu Ala Trp Gly Arg Met Asp 
    210                 215                 220                 


Ser Pro His Glu Tyr Gly Thr Trp Val Arg Val Arg Met Phe Arg Pro 
225                 230                 235                 240 


Pro Ser Leu Thr Leu Gln Pro His Ala Val Met Glu Gly Gln Pro Phe 
                245                 250                 255     


Lys Ala Thr Cys Thr Ala Ala Ala Tyr Tyr Pro Arg Asn Pro Val Glu 
            260                 265                 270         


Phe Asp Trp Phe Glu Asp Asp Arg Gln Val Phe Asn Pro Gly Gln Ile 
        275                 280                 285             


Asp Thr Gln Thr His Glu His Pro Asp Gly Phe Thr Thr Val Ser Thr 
    290                 295                 300                 


Val Thr Ser Glu Ala Val Gly Gly Gln Val Pro Pro Arg Thr Phe Thr 
305                 310                 315                 320 


Cys Gln Met Thr Trp His Arg Asp Ser Val Thr Phe Ser Arg Arg Asn 
                325                 330                 335     


Ala Thr Gly Leu Ala Leu Val Leu Pro Arg Pro Thr Ile Thr Met Glu 
            340                 345                 350         


Phe Gly Val Arg His Val Val Cys Thr Ala Gly Cys Val Pro Glu Gly 
        355                 360                 365             


Val Thr Phe Ala Trp Phe Leu Gly Asp Asp Pro Ser Pro Ala Ala Lys 
    370                 375                 380                 


Ser Ala Val Thr Ala Gln Glu Ser Cys Asp His Pro Gly Leu Ala Thr 
385                 390                 395                 400 


Val Arg Ser Thr Leu Pro Ile Ser Tyr Asp Tyr Ser Glu Tyr Ile Cys 
                405                 410                 415     


Arg Leu Thr Gly Tyr Pro Ala Gly Ile Pro Val Leu Glu His His 
            420                 425                 430     


<210>  9
<211>  511
<212>  PRT
<213>  Human alphaherpesvirus 1

<400>  9

Met Ala Pro Gly Arg Val Gly Leu Ala Val Val Leu Trp Gly Leu Leu 
1               5                   10                  15      


Trp Leu Gly Ala Gly Val Ala Gly Gly Ser Glu Thr Ala Ser Thr Gly 
            20                  25                  30          


Pro Thr Ile Thr Ala Gly Ala Val Thr Asn Ala Ser Glu Ala Pro Thr 
        35                  40                  45              


Ser Gly Ser Pro Gly Ser Ala Ala Ser Pro Glu Val Thr Pro Thr Ser 
    50                  55                  60                  


Thr Pro Asn Pro Asn Asn Val Thr Gln Asn Lys Thr Thr Pro Thr Glu 
65                  70                  75                  80  


Pro Ala Ser Pro Pro Thr Thr Pro Lys Pro Thr Ser Thr Pro Lys Ser 
                85                  90                  95      


Pro Pro Thr Ser Thr Pro Asp Pro Lys Pro Lys Asn Asn Thr Thr Pro 
            100                 105                 110         


Ala Lys Ser Gly Arg Pro Thr Lys Pro Pro Gly Pro Val Trp Cys Asp 
        115                 120                 125             


Arg Arg Asp Pro Leu Ala Arg Tyr Gly Ser Arg Val Gln Ile Arg Cys 
    130                 135                 140                 


Arg Phe Arg Asn Ser Thr Arg Met Glu Phe Arg Leu Gln Ile Trp Arg 
145                 150                 155                 160 


Tyr Ser Met Gly Pro Ser Pro Pro Ile Ala Pro Ala Pro Asp Leu Glu 
                165                 170                 175     


Glu Val Leu Thr Asn Ile Thr Ala Pro Pro Gly Gly Leu Leu Val Tyr 
            180                 185                 190         


Asp Ser Ala Pro Asn Leu Thr Asp Pro His Val Leu Trp Ala Glu Gly 
        195                 200                 205             


Ala Gly Pro Gly Ala Asp Pro Pro Leu Tyr Ser Val Thr Gly Pro Leu 
    210                 215                 220                 


Pro Thr Gln Arg Leu Ile Ile Gly Glu Val Thr Pro Ala Thr Gln Gly 
225                 230                 235                 240 


Met Tyr Tyr Leu Ala Trp Gly Arg Met Asp Ser Pro His Glu Tyr Gly 
                245                 250                 255     


Thr Trp Val Arg Val Arg Met Phe Arg Pro Pro Ser Leu Thr Leu Gln 
            260                 265                 270         


Pro His Ala Val Met Glu Gly Gln Pro Phe Lys Ala Thr Cys Thr Ala 
        275                 280                 285             


Ala Ala Tyr Tyr Pro Arg Asn Pro Val Glu Phe Asp Trp Phe Glu Asp 
    290                 295                 300                 


Asp Arg Gln Val Phe Asn Pro Gly Gln Ile Asp Thr Gln Thr His Glu 
305                 310                 315                 320 


His Pro Asp Gly Phe Thr Thr Val Ser Thr Val Thr Ser Glu Ala Val 
                325                 330                 335     


Gly Gly Gln Val Pro Pro Arg Thr Phe Thr Cys Gln Met Thr Trp His 
            340                 345                 350         


Arg Asp Ser Val Thr Phe Ser Arg Arg Asn Ala Thr Gly Leu Ala Leu 
        355                 360                 365             


Val Leu Pro Arg Pro Thr Ile Thr Met Glu Phe Gly Val Arg His Val 
    370                 375                 380                 


Val Cys Thr Ala Gly Cys Val Pro Glu Gly Val Thr Phe Ala Trp Phe 
385                 390                 395                 400 


Leu Gly Asp Asp Pro Ser Pro Ala Ala Lys Ser Ala Val Thr Ala Gln 
                405                 410                 415     


Glu Ser Cys Asp His Pro Gly Leu Ala Thr Val Arg Ser Thr Leu Pro 
            420                 425                 430         


Ile Ser Tyr Asp Tyr Ser Glu Tyr Ile Cys Arg Leu Thr Gly Tyr Pro 
        435                 440                 445             


Ala Gly Ile Pro Val Leu Glu His His Gly Ser His Gln Pro Pro Pro 
    450                 455                 460                 


Arg Asp Pro Thr Glu Arg Gln Val Ile Glu Ala Ile Glu Trp Val Gly 
465                 470                 475                 480 


Ile Gly Ile Gly Val Leu Ala Ala Gly Val Leu Val Val Thr Ala Ile 
                485                 490                 495     


Val Tyr Val Val Arg Thr Ser Gln Ser Arg Gln Arg His Arg Arg 
            500                 505                 510     


<210>  10
<211>  1668
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein C from Herpes Simplex Virus-2

<400>  10
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaugcgcau gcagcugcug cugcugaucg cccugucccu      180

ggcccuggug accaacuccg ccucccccgg ccgcaccauc accgugggcc cccgcggcaa      240

cgccuccaac gccgcccccu ccgccucccc ccgcaacgcc uccgcccccc gcaccacccc      300

cacccccccc cagccccgca aggccaccaa guccaaggcc uccaccgcca agcccgcccc      360

cccccccaag accggccccc ccaagaccuc cuccgagccc gugcgcugca accgccacga      420

cccccuggcc cgcuacggcu cccgcgugca gauccgcugc cgcuucccca acuccacccg      480

caccgaguuc cgccugcaga ucuggcgcua cgccaccgcc accgacgccg agaucggcac      540

cgcccccucc cuggaggagg ugauggugaa cguguccgcc ccccccggcg gccagcuggu      600

guacgacucc gcccccaacc gcaccgaccc ccacgugauc ugggccgagg gcgccggccc      660

cggcgccucc ccccgccugu acuccguggu gggcccccug ggccgccagc gccugaucau      720

cgaggagcug acccuggaga cccagggcau guacuacugg guguggggcc gcaccgaccg      780

ccccuccgcc uacggcaccu gggugcgcgu gcgcguguuc cgcccccccu cccugaccau      840

ccacccccac gccgugcugg agggccagcc cuucaaggcc accugcaccg ccgccaccua      900

cuaccccggc aaccgcgccg aguucgugug guucgaggac ggccgccgcg uguucgaccc      960

cgcccagauc cacacccaga cccaggagaa ccccgacggc uucuccaccg uguccaccgu     1020

gaccuccgcc gccgugggcg gccagggccc cccccgcacc uucaccugcc agcugaccug     1080

gcaccgcgac uccguguccu ucucccgccg caacgccucc ggcaccgccu ccgugcugcc     1140

ccgccccacc aucaccaugg aguucaccgg cgaccacgcc gugugcaccg ccggcugcgu     1200

gcccgagggc gugaccuucg ccugguuccu gggcgacgac uccucccccg ccgagaaggu     1260

ggccguggcc ucccagaccu ccugcggccg ccccggcacc gccaccaucc gcuccacccu     1320

gcccgugucc uacgagcaga ccgaguacau cugccgccug gccggcuacc ccgacggcau     1380

ccccgugcug gagcaccacu aacuaguagu gacugacuag gaucugguua ccacuaaacc     1440

agccucaaga acacccgaau ggagucucua agcuacauaa uaccaacuua cacuuacaaa     1500

auguuguccc ccaaaaugua gccauucgua ucugcuccua auaaaaagaa aguuucuuca     1560

cauucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaac                  1668


<210>  11
<211>  400
<212>  PRT
<213>  Human alphaherpesvirus 2

<400>  11

Ala Ser Pro Gly Arg Thr Ile Thr Val Gly Pro Arg Gly Asn Ala Ser 
1               5                   10                  15      


Asn Ala Ala Pro Ser Ala Ser Pro Arg Asn Ala Ser Ala Pro Arg Thr 
            20                  25                  30          


Thr Pro Thr Pro Pro Gln Pro Arg Lys Ala Thr Lys Ser Lys Ala Ser 
        35                  40                  45              


Thr Ala Lys Pro Ala Pro Pro Pro Lys Thr Gly Pro Pro Lys Thr Ser 
    50                  55                  60                  


Ser Glu Pro Val Arg Cys Asn Arg His Asp Pro Leu Ala Arg Tyr Gly 
65                  70                  75                  80  


Ser Arg Val Gln Ile Arg Cys Arg Phe Pro Asn Ser Thr Arg Thr Glu 
                85                  90                  95      


Ser Arg Leu Gln Ile Trp Arg Tyr Ala Thr Ala Thr Asp Ala Glu Ile 
            100                 105                 110         


Gly Thr Ala Pro Ser Leu Glu Glu Val Met Val Asn Val Ser Ala Pro 
        115                 120                 125             


Pro Gly Gly Gln Leu Val Tyr Asp Ser Ala Pro Asn Arg Thr Asp Pro 
    130                 135                 140                 


His Val Ile Trp Ala Glu Gly Ala Gly Pro Gly Ala Ser Pro Arg Leu 
145                 150                 155                 160 


Tyr Ser Val Val Gly Pro Leu Gly Arg Gln Arg Leu Ile Ile Glu Glu 
                165                 170                 175     


Leu Thr Leu Glu Thr Gln Gly Met Tyr Tyr Trp Val Trp Gly Arg Thr 
            180                 185                 190         


Asp Arg Pro Ser Ala Tyr Gly Thr Trp Val Arg Val Arg Val Phe Arg 
        195                 200                 205             


Pro Pro Ser Leu Thr Ile His Pro His Ala Val Leu Glu Gly Gln Pro 
    210                 215                 220                 


Phe Lys Ala Thr Cys Thr Ala Ala Thr Tyr Tyr Pro Gly Asn Arg Ala 
225                 230                 235                 240 


Glu Phe Val Trp Phe Glu Asp Gly Arg Arg Val Phe Asp Pro Ala Gln 
                245                 250                 255     


Ile His Thr Gln Thr Gln Glu Asn Pro Asp Gly Phe Ser Thr Val Ser 
            260                 265                 270         


Thr Val Thr Ser Ala Ala Val Gly Gly Gln Gly Pro Pro Arg Thr Phe 
        275                 280                 285             


Thr Cys Gln Leu Thr Trp His Arg Asp Ser Val Ser Phe Ser Arg Arg 
    290                 295                 300                 


Asn Ala Ser Gly Thr Ala Ser Val Leu Pro Arg Pro Thr Ile Thr Met 
305                 310                 315                 320 


Glu Phe Thr Gly Asp His Ala Val Cys Thr Ala Gly Cys Val Pro Glu 
                325                 330                 335     


Gly Val Thr Phe Ala Trp Phe Leu Gly Asp Asp Ser Ser Pro Ala Glu 
            340                 345                 350         


Lys Val Ala Val Ala Ser Gln Thr Ser Cys Gly Arg Pro Gly Thr Ala 
        355                 360                 365             


Thr Ile Arg Ser Thr Leu Pro Val Ser Tyr Glu Gln Thr Glu Tyr Ile 
    370                 375                 380                 


Cys Arg Leu Ala Gly Tyr Pro Asp Gly Ile Pro Val Leu Glu His His 
385                 390                 395                 400 


<210>  12
<211>  480
<212>  PRT
<213>  Human alphaherpesvirus 2

<400>  12

Met Ala Leu Gly Arg Val Gly Leu Ala Val Gly Leu Trp Gly Leu Leu 
1               5                   10                  15      


Trp Val Gly Val Val Val Val Leu Ala Asn Ala Ser Pro Gly Arg Thr 
            20                  25                  30          


Ile Thr Val Gly Pro Arg Gly Asn Ala Ser Asn Ala Ala Pro Ser Ala 
        35                  40                  45              


Ser Pro Arg Asn Ala Ser Ala Pro Arg Thr Thr Pro Thr Pro Pro Gln 
    50                  55                  60                  


Pro Arg Lys Ala Thr Lys Ser Lys Ala Ser Thr Ala Lys Pro Ala Pro 
65                  70                  75                  80  


Pro Pro Lys Thr Gly Pro Pro Lys Thr Ser Ser Glu Pro Val Arg Cys 
                85                  90                  95      


Asn Arg His Asp Pro Leu Ala Arg Tyr Gly Ser Arg Val Gln Ile Arg 
            100                 105                 110         


Cys Arg Phe Pro Asn Ser Thr Arg Thr Glu Phe Arg Leu Gln Ile Trp 
        115                 120                 125             


Arg Tyr Ala Thr Ala Thr Asp Ala Glu Ile Gly Thr Ala Pro Ser Leu 
    130                 135                 140                 


Glu Glu Val Met Val Asn Val Ser Ala Pro Pro Gly Gly Gln Leu Val 
145                 150                 155                 160 


Tyr Asp Ser Ala Pro Asn Arg Thr Asp Pro His Val Ile Trp Ala Glu 
                165                 170                 175     


Gly Ala Gly Pro Gly Ala Ser Pro Arg Leu Tyr Ser Val Val Gly Pro 
            180                 185                 190         


Leu Gly Arg Gln Arg Leu Ile Ile Glu Glu Leu Thr Leu Glu Thr Gln 
        195                 200                 205             


Gly Met Tyr Tyr Trp Val Trp Gly Arg Thr Asp Arg Pro Ser Ala Tyr 
    210                 215                 220                 


Gly Thr Trp Val Arg Val Arg Val Phe Arg Pro Pro Ser Leu Thr Ile 
225                 230                 235                 240 


His Pro His Ala Val Leu Glu Gly Gln Pro Phe Lys Ala Thr Cys Thr 
                245                 250                 255     


Ala Ala Thr Tyr Tyr Pro Gly Asn Arg Ala Glu Phe Val Trp Phe Glu 
            260                 265                 270         


Asp Gly Arg Arg Val Phe Asp Pro Ala Gln Ile His Thr Gln Thr Gln 
        275                 280                 285             


Glu Asn Pro Asp Gly Phe Ser Thr Val Ser Thr Val Thr Ser Ala Ala 
    290                 295                 300                 


Val Gly Gly Gln Gly Pro Pro Arg Thr Phe Thr Cys Gln Leu Thr Trp 
305                 310                 315                 320 


His Arg Asp Ser Val Ser Phe Ser Arg Arg Asn Ala Ser Gly Thr Ala 
                325                 330                 335     


Ser Val Leu Pro Arg Pro Thr Ile Thr Met Glu Phe Thr Gly Asp His 
            340                 345                 350         


Ala Val Cys Thr Ala Gly Cys Val Pro Glu Gly Val Thr Phe Ala Trp 
        355                 360                 365             


Phe Leu Gly Asp Asp Ser Ser Pro Ala Glu Lys Val Ala Val Ala Ser 
    370                 375                 380                 


Gln Thr Ser Cys Gly Arg Pro Gly Thr Ala Thr Ile Arg Ser Thr Leu 
385                 390                 395                 400 


Pro Val Ser Tyr Glu Gln Thr Glu Tyr Ile Cys Arg Leu Ala Gly Tyr 
                405                 410                 415     


Pro Asp Gly Ile Pro Val Leu Glu His His Gly Ser His Gln Pro Pro 
            420                 425                 430         


Pro Arg Asp Pro Thr Glu Arg Gln Val Ile Arg Ala Val Glu Gly Ala 
        435                 440                 445             


Gly Ile Gly Val Ala Val Leu Val Ala Val Val Leu Ala Gly Thr Ala 
    450                 455                 460                 


Val Val Tyr Leu Thr His Ala Ser Ser Val Arg Tyr Arg Arg Leu Arg 
465                 470                 475                 480 


<210>  13
<211>  1626
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein E from Herpes Simplex Virus-1

<400>  13
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaugcgcau gcagcugcug cugcugaucg cccugucccu      180

ggcccuggug accaacucca agaccuccug gcgccgcgug uccgugggcg aggacguguc      240

ccugcugccc gcccccggcc ccaccggccg cggccccacc cagaagcugc ugugggccgu      300

ggagccccug gacggcugcg gcccccugca ccccuccugg gugucccuga ugccccccaa      360

gcaggugccc gagaccgugg uggacgccgc cugcaugcgc gcccccgugc cccuggccau      420

ggccuacgcc ccccccgccc ccuccgccac cggcggccug cgcaccgacu ucguguggca      480

ggagcgcgcc gccgugguga accgcucccu ggugaucuac ggcgugcgcg agaccgacuc      540

cggccuguac acccuguccg ugggcgacau caaggacccc gcccgccagg uggccuccgu      600

ggugcuggug gugcagcccg cccccgugcc cacccccccc cccacccccg ccgacuacga      660

cgaggacgac aacgacgagg gcgagggcga ggacgagucc cuggccggca cccccgccuc      720

cggcaccccc cgccugcccc ccucccccgc ccccccccgc uccuggcccu ccgcccccga      780

ggugucccac gugcgcggcg ugaccgugcg cauggagacc cccgaggcca uccuguucuc      840

ccccggcgag gccuucucca ccaacguguc cauccacgcc aucgcccacg acgaccagac      900

cuacaccaug gacguggugu ggcugcgcuu cgacgugccc accuccugcg ccgagaugcg      960

caucuacgag uccugccugu accaccccca gcugcccgag ugccuguccc ccgccgacgc     1020

ccccugcgcc gccuccaccu ggaccucccg ccuggccgug cgcuccuacg ccggcugcuc     1080

ccgcaccaac cccccccccc gcugcuccgc cgaggcccac auggagcccu uccccggccu     1140

ggccuggcag gccgccuccg ugaaccugga guuccgcgac gccucccccc agcacuccgg     1200

ccuguaccug ugcguggugu acgugaacga ccacauccac gccuggggcc acaucaccau     1260

caacaccgcc gcccaguacc gcaacgccgu gguggagcag ccccugcccc agcgcggcgc     1320

cgaccuggcc gagcccaccc acccccacgu gggcgccuaa cuaguaguga cugacuagga     1380

ucugguuacc acuaaaccag ccucaagaac acccgaaugg agucucuaag cuacauaaua     1440

ccaacuuaca cuuacaaaau guuguccccc aaaauguagc cauucguauc ugcuccuaau     1500

aaaaagaaag uuucuucaca uucuaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaac                                                                1626


<210>  14
<211>  386
<212>  PRT
<213>  Human alphaherpesvirus 1

<400>  14

Lys Thr Ser Trp Arg Arg Val Ser Val Gly Glu Asp Val Ser Leu Leu 
1               5                   10                  15      


Pro Ala Pro Gly Pro Thr Gly Arg Gly Pro Thr Gln Lys Leu Leu Trp 
            20                  25                  30          


Ala Val Glu Pro Leu Asp Gly Cys Gly Pro Leu His Pro Ser Trp Val 
        35                  40                  45              


Ser Leu Met Pro Pro Lys Gln Val Pro Glu Thr Val Val Asp Ala Ala 
    50                  55                  60                  


Cys Met Arg Ala Pro Val Pro Leu Ala Met Ala Tyr Ala Pro Pro Ala 
65                  70                  75                  80  


Pro Ser Ala Thr Gly Gly Leu Arg Thr Asp Phe Val Trp Gln Glu Arg 
                85                  90                  95      


Ala Ala Val Val Asn Arg Ser Leu Val Ile Tyr Gly Val Arg Glu Thr 
            100                 105                 110         


Asp Ser Gly Leu Tyr Thr Leu Ser Val Gly Asp Ile Lys Asp Pro Ala 
        115                 120                 125             


Arg Gln Val Ala Ser Val Val Leu Val Val Gln Pro Ala Pro Val Pro 
    130                 135                 140                 


Thr Pro Pro Pro Thr Pro Ala Asp Tyr Asp Glu Asp Asp Asn Asp Glu 
145                 150                 155                 160 


Gly Glu Gly Glu Asp Glu Ser Leu Ala Gly Thr Pro Ala Ser Gly Thr 
                165                 170                 175     


Pro Arg Leu Pro Pro Ser Pro Ala Pro Pro Arg Ser Trp Pro Ser Ala 
            180                 185                 190         


Pro Glu Val Ser His Val Arg Gly Val Thr Val Arg Met Glu Thr Pro 
        195                 200                 205             


Glu Ala Ile Leu Phe Ser Pro Gly Glu Ala Phe Ser Thr Asn Val Ser 
    210                 215                 220                 


Ile His Ala Ile Ala His Asp Asp Gln Thr Tyr Thr Met Asp Val Val 
225                 230                 235                 240 


Trp Leu Arg Phe Asp Val Pro Thr Ser Cys Ala Glu Met Arg Ile Tyr 
                245                 250                 255     


Glu Ser Cys Leu Tyr His Pro Gln Leu Pro Glu Cys Leu Ser Pro Ala 
            260                 265                 270         


Asp Ala Pro Cys Ala Ala Ser Thr Trp Thr Ser Arg Leu Ala Val Arg 
        275                 280                 285             


Ser Tyr Ala Gly Cys Ser Arg Thr Asn Pro Pro Pro Arg Cys Ser Ala 
    290                 295                 300                 


Glu Ala His Met Glu Pro Phe Pro Gly Leu Ala Trp Gln Ala Ala Ser 
305                 310                 315                 320 


Val Asn Leu Glu Phe Arg Asp Ala Ser Pro Gln His Ser Gly Leu Tyr 
                325                 330                 335     


Leu Cys Val Val Tyr Val Asn Asp His Ile His Ala Trp Gly His Ile 
            340                 345                 350         


Thr Ile Asn Thr Ala Ala Gln Tyr Arg Asn Ala Val Val Glu Gln Pro 
        355                 360                 365             


Leu Pro Gln Arg Gly Ala Asp Leu Ala Glu Pro Thr His Pro His Val 
    370                 375                 380                 


Gly Ala 
385     


<210>  15
<211>  552
<212>  PRT
<213>  Human alphaherpesvirus 1

<400>  15

Met Asp Arg Gly Ala Val Val Gly Phe Leu Leu Gly Val Cys Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Gly Thr Pro Lys Thr Ser Trp Arg Arg Val Ser Val 
            20                  25                  30          


Gly Glu Asp Val Ser Leu Leu Pro Ala Pro Gly Pro Thr Gly Arg Gly 
        35                  40                  45              


Pro Thr Gln Lys Leu Leu Trp Ala Val Glu Pro Leu Asp Gly Cys Gly 
    50                  55                  60                  


Pro Leu His Pro Ser Trp Val Ser Leu Met Pro Pro Lys Gln Val Pro 
65                  70                  75                  80  


Glu Thr Val Val Asp Ala Ala Cys Met Arg Ala Pro Val Pro Leu Ala 
                85                  90                  95      


Met Ala Tyr Ala Pro Pro Ala Pro Ser Ala Thr Gly Gly Leu Arg Thr 
            100                 105                 110         


Asp Phe Val Trp Gln Glu Arg Ala Ala Val Val Asn Arg Ser Leu Val 
        115                 120                 125             


Ile Tyr Gly Val Arg Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val 
    130                 135                 140                 


Gly Asp Ile Lys Asp Pro Ala Arg Gln Val Ala Ser Val Val Leu Val 
145                 150                 155                 160 


Val Gln Pro Ala Pro Val Pro Thr Pro Pro Pro Thr Pro Ala Asp Tyr 
                165                 170                 175     


Asp Glu Asp Asp Asn Asp Glu Gly Glu Gly Glu Asp Glu Ser Leu Ala 
            180                 185                 190         


Gly Thr Pro Ala Ser Gly Thr Pro Arg Leu Pro Pro Ser Pro Ala Pro 
        195                 200                 205             


Pro Arg Ser Trp Pro Ser Ala Pro Glu Val Ser His Val Arg Gly Val 
    210                 215                 220                 


Thr Val Arg Met Glu Thr Pro Glu Ala Ile Leu Phe Ser Pro Gly Glu 
225                 230                 235                 240 


Ala Phe Ser Thr Asn Val Ser Ile His Ala Ile Ala His Asp Asp Gln 
                245                 250                 255     


Thr Tyr Thr Met Asp Val Val Trp Leu Arg Phe Asp Val Pro Thr Ser 
            260                 265                 270         


Cys Ala Glu Met Arg Ile Tyr Glu Ser Cys Leu Tyr His Pro Gln Leu 
        275                 280                 285             


Pro Glu Cys Leu Ser Pro Ala Asp Ala Pro Cys Ala Ala Ser Thr Trp 
    290                 295                 300                 


Thr Ser Arg Leu Ala Val Arg Ser Tyr Ala Gly Cys Ser Arg Thr Asn 
305                 310                 315                 320 


Pro Pro Pro Arg Cys Ser Ala Glu Ala His Met Glu Pro Phe Pro Gly 
                325                 330                 335     


Leu Ala Trp Gln Ala Ala Ser Val Asn Leu Glu Phe Arg Asp Ala Ser 
            340                 345                 350         


Pro Gln His Ser Gly Leu Tyr Leu Cys Val Val Tyr Val Asn Asp His 
        355                 360                 365             


Ile His Ala Trp Gly His Ile Thr Ile Asn Thr Ala Ala Gln Tyr Arg 
    370                 375                 380                 


Asn Ala Val Val Glu Gln Pro Leu Pro Gln Arg Gly Ala Asp Leu Ala 
385                 390                 395                 400 


Glu Pro Thr His Pro His Val Gly Ala Pro Pro His Ala Pro Pro Thr 
                405                 410                 415     


His Gly Ala Leu Arg Leu Gly Ala Val Met Gly Ala Ala Leu Leu Leu 
            420                 425                 430         


Ser Ala Leu Gly Leu Ser Val Trp Ala Cys Met Thr Cys Trp Arg Arg 
        435                 440                 445             


Arg Ala Trp Arg Ala Val Lys Ser Arg Ala Ser Gly Lys Gly Pro Thr 
    450                 455                 460                 


Tyr Ile Arg Val Ala Asp Ser Glu Leu Tyr Ala Asp Trp Ser Ser Asp 
465                 470                 475                 480 


Ser Glu Gly Glu Arg Asp Gln Val Pro Trp Leu Ala Pro Pro Glu Arg 
                485                 490                 495     


Pro Asp Ser Pro Ser Thr Asn Gly Ser Gly Phe Glu Ile Leu Ser Pro 
            500                 505                 510         


Thr Ala Pro Ser Val Tyr Pro Arg Ser Asp Gly His Gln Ser Arg Arg 
        515                 520                 525             


Gln Leu Thr Thr Phe Gly Ser Gly Arg Pro Asp Arg Arg Tyr Ser Gln 
    530                 535                 540                 


Ala Ser Asp Ser Ser Val Phe Trp 
545                 550         


<210>  16
<211>  1614
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  All uridine residues are 1-methyl-pseudouridine - encodes 
       glycoprotein E from Herpes Simplex Virus-2

<400>  16
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaugcgcau gcagcugcug cugcugaucg cccugucccu      180

ggcccuggug accaacuccc gcaccuccug gaagcgcgug accuccggcg aggacguggu      240

gcugcugccc gcccccgccg gccccgagga gcgcacccgc gcccacaagc ugcugugggc      300

cgccgagccc cuggacgccu gcggcccccu gcgccccucc uggguggccc uguggccccc      360

ccgccgcgug cuggagaccg ugguggacgc cgccugcaug cgcgcccccg agccccuggc      420

caucgccuac uccccccccu uccccgccgg cgacgagggc cuguacuccg agcuggccug      480

gcgcgaccgc guggccgugg ugaacgaguc ccuggugauc uacggcgccc uggagaccga      540

cuccggccug uacacccugu ccgugguggg ccuguccgac gaggcccgcc agguggccuc      600

cguggugcug gugguggagc ccgcccccgu gcccaccccc acccccgacg acuacgacga      660

ggaggacgac gccggcgugu ccgagcgcac ccccgugucc gugccccccc ccaccccccc      720

ccgccgcccc cccguggccc cccccaccca cccccgcgug auccccgagg ugucccacgu      780

gcgcggcgug accgugcaca uggagacccc cgaggccauc cuguucgccc ccggcgagac      840

cuucggcacc aacgugucca uccacgccau cgcccacgac gacggccccu acgccaugga      900

cguggugugg augcgcuucg acgugcccuc cuccugcgcc gagaugcgca ucuacgaggc      960

cugccuguac cacccccagc ugcccgagug ccuguccccc gccgacgccc ccugcgccgu     1020

guccuccugg gccuaccgcc uggccgugcg cuccuacgcc ggcugcuccc gcaccacccc     1080

ccccccccgc ugcuucgccg aggcccgcau ggagcccgug cccggccugg ccuggcuggc     1140

cuccaccgug aaccuggagu uccagcacgc cuccccccag cacgccggcc uguaccugug     1200

cgugguguac guggacgacc acauccacgc cuggggccac augaccaucu ccaccgccgc     1260

ccaguaccgc aacgccgugg uggagcagca ccugccccag cgccagcccg agcccgugga     1320

gcccacccgc ccccacgugc gcgccuaacu aguagugacu gacuaggauc ugguuaccac     1380

uaaaccagcc ucaagaacac ccgaauggag ucucuaagcu acauaauacc aacuuacacu     1440

uacaaaaugu ugucccccaa aauguagcca uucguaucug cuccuaauaa aaagaaaguu     1500

ucuucacauu cuaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaac           1614


<210>  17
<211>  382
<212>  PRT
<213>  Human alphaherpesvirus 2

<400>  17

Arg Thr Ser Trp Lys Arg Val Thr Ser Gly Glu Asp Val Val Leu Leu 
1               5                   10                  15      


Pro Ala Pro Ala Gly Pro Glu Glu Arg Thr Arg Ala His Lys Leu Leu 
            20                  25                  30          


Trp Ala Ala Glu Pro Leu Asp Ala Cys Gly Pro Leu Arg Pro Ser Trp 
        35                  40                  45              


Val Ala Leu Trp Pro Pro Arg Arg Val Leu Glu Thr Val Val Asp Ala 
    50                  55                  60                  


Ala Cys Met Arg Ala Pro Glu Pro Leu Ala Ile Ala Tyr Ser Pro Pro 
65                  70                  75                  80  


Phe Pro Ala Gly Asp Glu Gly Leu Tyr Ser Glu Leu Ala Trp Arg Asp 
                85                  90                  95      


Arg Val Ala Val Val Asn Glu Ser Leu Val Ile Tyr Gly Ala Leu Glu 
            100                 105                 110         


Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val Val Gly Leu Ser Asp Glu 
        115                 120                 125             


Ala Arg Gln Val Ala Ser Val Val Leu Val Val Glu Pro Ala Pro Val 
    130                 135                 140                 


Pro Thr Pro Thr Pro Asp Asp Tyr Asp Glu Glu Asp Asp Ala Gly Val 
145                 150                 155                 160 


Ser Glu Arg Thr Pro Val Ser Val Pro Pro Pro Thr Pro Pro Arg Arg 
                165                 170                 175     


Pro Pro Val Ala Pro Pro Thr His Pro Arg Val Ile Pro Glu Val Ser 
            180                 185                 190         


His Val Arg Gly Val Thr Val His Met Glu Thr Pro Glu Ala Ile Leu 
        195                 200                 205             


Phe Ala Pro Gly Glu Thr Phe Gly Thr Asn Val Ser Ile His Ala Ile 
    210                 215                 220                 


Ala His Asp Asp Gly Pro Tyr Ala Met Asp Val Val Trp Met Arg Phe 
225                 230                 235                 240 


Asp Val Pro Ser Ser Cys Ala Glu Met Arg Ile Tyr Glu Ala Cys Leu 
                245                 250                 255     


Tyr His Pro Gln Leu Pro Glu Cys Leu Ser Pro Ala Asp Ala Pro Cys 
            260                 265                 270         


Ala Val Ser Ser Trp Ala Tyr Arg Leu Ala Val Arg Ser Tyr Ala Gly 
        275                 280                 285             


Cys Ser Arg Thr Thr Pro Pro Pro Arg Cys Phe Ala Glu Ala Arg Met 
    290                 295                 300                 


Glu Pro Val Pro Gly Leu Ala Trp Leu Ala Ser Thr Val Asn Leu Glu 
305                 310                 315                 320 


Phe Gln His Ala Ser Pro Gln His Ala Gly Leu Tyr Leu Cys Val Val 
                325                 330                 335     


Tyr Val Asp Asp His Ile His Ala Trp Gly His Met Thr Ile Ser Thr 
            340                 345                 350         


Ala Ala Gln Tyr Arg Asn Ala Val Val Glu Gln His Leu Pro Gln Arg 
        355                 360                 365             


Gln Pro Glu Pro Val Glu Pro Thr Arg Pro His Val Arg Ala 
    370                 375                 380         


<210>  18
<211>  545
<212>  PRT
<213>  Human alphaherpesvirus 2

<400>  18

Met Ala Arg Gly Ala Gly Leu Val Phe Phe Val Gly Val Trp Val Val 
1               5                   10                  15      


Ser Cys Leu Ala Ala Ala Pro Arg Thr Ser Trp Lys Arg Val Thr Ser 
            20                  25                  30          


Gly Glu Asp Val Val Leu Leu Pro Ala Pro Ala Glu Arg Thr Arg Ala 
        35                  40                  45              


His Lys Leu Leu Trp Ala Ala Glu Pro Leu Asp Ala Cys Gly Pro Leu 
    50                  55                  60                  


Arg Pro Ser Trp Val Ala Leu Trp Pro Pro Arg Arg Val Leu Glu Thr 
65                  70                  75                  80  


Val Val Asp Ala Ala Cys Met Arg Ala Pro Glu Pro Leu Ala Ile Ala 
                85                  90                  95      


Tyr Ser Pro Pro Phe Pro Ala Gly Asp Glu Gly Leu Tyr Ser Glu Leu 
            100                 105                 110         


Ala Trp Arg Asp Arg Val Ala Val Val Asn Glu Ser Leu Val Ile Tyr 
        115                 120                 125             


Gly Ala Leu Glu Thr Asp Ser Gly Leu Tyr Thr Leu Ser Val Val Gly 
    130                 135                 140                 


Leu Ser Asp Glu Ala Arg Gln Val Ala Ser Val Val Leu Val Val Glu 
145                 150                 155                 160 


Pro Ala Pro Val Pro Thr Pro Thr Pro Asp Asp Tyr Asp Glu Glu Asp 
                165                 170                 175     


Asp Ala Gly Val Thr Asn Ala Arg Arg Ser Ala Phe Pro Pro Gln Pro 
            180                 185                 190         


Pro Pro Arg Arg Pro Pro Val Ala Pro Pro Thr His Pro Arg Val Ile 
        195                 200                 205             


Pro Glu Val Ser His Val Arg Gly Val Thr Val His Met Glu Thr Leu 
    210                 215                 220                 


Glu Ala Ile Leu Phe Ala Pro Gly Glu Thr Phe Gly Thr Asn Val Ser 
225                 230                 235                 240 


Ile His Ala Ile Ala His Asp Asp Gly Pro Tyr Ala Met Asp Val Val 
                245                 250                 255     


Trp Met Arg Phe Asp Val Pro Ser Ser Cys Ala Asp Met Arg Ile Tyr 
            260                 265                 270         


Glu Ala Cys Leu Tyr His Pro Gln Leu Pro Glu Cys Leu Ser Pro Ala 
        275                 280                 285             


Asp Ala Pro Cys Ala Val Ser Ser Trp Ala Tyr Arg Leu Ala Val Arg 
    290                 295                 300                 


Ser Tyr Ala Gly Cys Ser Arg Thr Thr Pro Pro Pro Arg Cys Phe Ala 
305                 310                 315                 320 


Glu Ala Arg Met Glu Pro Val Pro Gly Leu Ala Trp Leu Ala Ser Thr 
                325                 330                 335     


Val Asn Leu Glu Phe Gln His Ala Ser Pro Gln His Ala Gly Leu Tyr 
            340                 345                 350         


Leu Cys Val Val Tyr Val Asp Asp His Ile His Ala Trp Gly His Met 
        355                 360                 365             


Thr Ile Ser Thr Ala Ala Gln Tyr Arg Asn Ala Val Val Glu Gln His 
    370                 375                 380                 


Leu Pro Gln Arg Gln Pro Glu Pro Val Glu Pro Thr Arg Pro His Val 
385                 390                 395                 400 


Arg Ala Pro His Pro Ala Pro Ser Ala Arg Gly Pro Leu Arg Leu Gly 
                405                 410                 415     


Ala Val Leu Gly Ala Ala Leu Leu Leu Ala Ala Leu Gly Leu Ser Ala 
            420                 425                 430         


Trp Ala Cys Met Thr Cys Trp Arg Arg Arg Ser Trp Arg Ala Val Lys 
        435                 440                 445             


Ser Arg Ala Ser Ala Thr Gly Pro Thr Tyr Ile Arg Val Ala Asp Ser 
    450                 455                 460                 


Glu Leu Tyr Ala Asp Trp Ser Ser Asp Ser Glu Gly Glu Arg Asp Gly 
465                 470                 475                 480 


Ser Leu Trp Gln Asp Pro Pro Glu Arg Pro Asp Ser Pro Ser Thr Asn 
                485                 490                 495     


Gly Ser Gly Phe Glu Ile Leu Ser Pro Thr Ala Pro Ser Val Tyr Pro 
            500                 505                 510         


His Ser Glu Gly Arg Lys Ser Arg Arg Pro Leu Thr Thr Phe Gly Ser 
        515                 520                 525             


Gly Ser Pro Gly Arg Arg His Ser Gln Ala Ser Tyr Pro Ser Val Leu 
    530                 535                 540                 


Trp 
545 


