                         б

<110>  Ŵѧ
       ޹˾
 
<120>  һİɲ

<130>  IEC170087PCT

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  7428
<212>  DNA
<213>  ˹

<220>
<223>  ECHO25-WTcDNA

<400>  1
ttaaaacagc ctgtgggttg ttcccaccca tagggcccac tgggcgctag cacactggta       60

ttgtggtacc tttgtgcgcc tgttttatct acccctcccc caaacgtgac ttagaagctc      120

aacacatgtg gtcagcaggt ggcccagtat accaactggg tcttgatcaa gcacttctgt      180

taccccggac cgagtatcaa taggctgctc acgcggctga aggagaaagt gttcgttatc      240

cggccaatta ctacgagaaa cctagtacca ccatggaagt tgcgcggcgt ttcgctccgc      300

acaaccccag tgtagatcag gccgatgagt caccgcactc ctcacgggcg accgtggcgg      360

tggctgcgct ggcggcctgc ccatggggca acccatggga cgcttcaata ccgacatggt      420

gtgaagagtc tattgtgcta attggtaatc ctccggcccc tgaatgcggc taatcccaac      480

tgcggagcag atacccacat gccagtgggc agtctgtcgt aacgggtaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttctt tttattcttt attggctgct tatggtgaca      600

attgagagat tgttgccata tagctattgg attggccatc cggtgacaaa cagaacaata      660

gtttatctat ttgttggttt cataccatta aattttaaag tattaaagac tatcaacttg      720

atcatactac ttaatacagc aaaatgggag ctcatgtgtc aacgcagaaa accggagcgc      780

atgagactgg tttgagcgcc agtgggaatt cggttattca ttacacaaca tcaattatta      840

caaggatgca tcttcaaatt cagcaaacag gcaagacttt tcacaagacc ccagcaaatt      900

taccgaaccc tatgaaggat gtcatgatta aatcactccc ggcgttaaat tcacccactg      960

tggaggaatg tggctacagt gaccgggtgc gctccattac tttgggtaat tcaacaatca     1020

ctacgcagga aagtgcaaat gtggtagttg gctatggtgt ctggccggag tatttgaggg     1080

atgaggaagc cacggcacaa gaccaaccca ctcaaccaga tgttgccacc tgtagattct     1140

acaccctaga atctgttatg tgggagaagt cctcggcggg ctggtggtgg aagtttccag     1200

atgctcttgc agagatgggc ctattcggtc aaaatatgct ataccattat ttgggaaggt     1260

caggctacac aatacacgtg caatgcaatg cgtcaaaatt ccaccaaggg tgccttcttg     1320

tagtctgtgt gccagaagcc gagatgggtt ctgcacagct tgataggaca ttgaatcata     1380

ccaaacttag caacacagaa cacgccagca cattcgggtc catgagttcc aatgaagctg     1440

gggccgtcca aaatgtagtg cacaatgccg ggatgggcgt tggagtgggt aacttgacca     1500

tctaccctca tcagtggatt aatcttagaa ccaacaattg tgccaccata gtaatgccgt     1560

acataaacag tgtgccaatg gataatatgt ttaggcatta caatttcacc cttatggtga     1620

ttccattcgc acagcttgat tatgcaccca gcgcgtccac tcacgttcca ataaccgtga     1680

cagttgcccc catgtgtgcc gaatacaacg ggctaagatt ggcaggtaaa cagggcttac     1740

caacaatgct cactccaggt agcaaccagt tcctcacgtc tgatgatttc cagtccccat     1800

cagcaatgcc acagtttgat gtaacgccgg agattgaaat ccccggtgac gtgaagaatt     1860

taatggaaat ggctgaagtt gattctgtgg tcccagtgaa taatctggat gataaggtaa     1920

attcaattga agcttataca atccccgtca aatcaatgag tggtattgcg acacaagtcg     1980

ttgggttcca attacaaccc ggggacgata gtgcgtttaa gaggacactg ttaggagaga     2040

ttttgaacta ctttgcaaat tggtcgggaa ttatcaaact gacattccca tactgcggtg     2100

cggcgatgac cactggcaca ttcctgatcg cctactcccc tcctggtgct ggcttccctg     2160

ctaaccgcaa ggactcaatg ttgggcactc acattgtctg ggacatagga ttgcaatcga     2220

gttgtgtgct ctgcgtgcca tggatcagtc agacaaacta ccgcttcgtg acgcatgacg     2280

cttatacaga cgctgggttt attacatgct ggtaccaaac aaacatagtg tcacccccag     2340

acatcccggc agacagtaca atcctatgtt ttgtttcagc ttgtaatgat ttctcggtgc     2400

gcttgttaag ggacacgcca ttcatatcac aaaacgcact tctccaaaat gacccggcta     2460

ctgccattgt tagatcagtg gaacgggtgg ccgataccat agcaagtggc ccaatgaatt     2520

ccgagagagt cccagcattg actgccgtcg agacgggtca cacatctcaa gttgttccca     2580

gtgatactat gcaaaccagg catgttgtta accatcacat tagatcggaa tcttcaatag     2640

agaattttct gagtagatcg gcatgcgttt acattgatgt gtatggcaca aaagagaatg     2700

gtgacatcga acgtttcact aactggaaga tcaacacacg ccaggttgtt cagctgaggc     2760

gcaagctgga gatgttcact tacatcagat ttgatgtgga aataacattc gtaattacaa     2820

gtactcaagg gacatcaacc caaacaagca ctggcacccc agtgctcaca catcaagtga     2880

tgtatgtgcc acccggaggc cccatacccg cgtcatatga ggattatagc tggcaaactt     2940

cgacaaaccc cagcgttttc tggacagaag ggaatgcacc ggctcgcatg tcaataccct     3000

ttatgagtgt gggcaatgcc tattgcaact tttatgatgg ctggtcacat ttctcgcaat     3060

ccggcgtgta tggtttcact accctgaaca acatgggaca gctgtttttc agacatgtga     3120

ataaggacac acttggccct tacaacagca cagtgcgtgt ctatttcaaa ccaaagcaca     3180

tcaaagcatg ggtgcccaga ccaccgcgtc tatgcgatta tgtgtatgca cataatgtcg     3240

atttcacccc cagaggagtc acggacataa gggaaaagat cacactggaa agagacgacc     3300

acacgccttc gatggtaaac cacggtgctt ttggacagca gtctggcgcc atttacgtgg     3360

gtaactacag agtggtaaat aggcacctgg ccacctatgc cgattggcag aattgcgtgt     3420

gggaagatta taatagagac ctcttagtga gcacaaccac agcgcacggg tgtgacacca     3480

tcgctaggtg tcaatgctgc acgggtgtct acttttgtgc ctcaaggaac aagcactacc     3540

cagttagctt tgaagggcca ggcctagtgg aagttcagga gagtgagtat tacccaaaga     3600

gataccagtc ccacgtgctg ttagccgcag ggttttctga accaggagac tgtggtggaa     3660

ttctcaggtg cgagcatggt gttatcggac tagttaccat gggtggcgaa ggcgtagtcg     3720

gctttgctga tgtgcgcgac ctgctgtggt tggaggatga tgcaatggaa caaggggtca     3780

agggttatgt agaacaattg ggcaatgcct tcggttccgg gttcaccaat caaatctgcg     3840

aacaagtcaa cctcctcaaa gaatcactag tgggccaaga ttccatacta gagaagtccc     3900

ttaaagctct tgtgaaaatc atttcagcac tggtaatagt agtgaggaac catgatgact     3960

taattactgt gactgccacc ctcgctctaa ttggctgcac ctcatcgccg tggcggtggc     4020

ttaaacagaa ggtgtcacag tattacggga tacccatggc tgagcgacaa aacaacgggt     4080

ggctcaaaaa gtttacagag atgaccaatg cctgcaaagg gatggagtgg attgccgtca     4140

agatccaaaa gtttatagaa tggctcaaga ttaaaatctt accagaggta aaggagaagc     4200

atgagttcct aaccagactt aaacaactcc cccttctgga aagccaaatt gccaccattg     4260

aacaaagtgc accgtcccag agtgatcagg aacaactctt ctcaaatgtt caatacttcg     4320

cccactactg cagaaagtac gcacctctgt atgctactga ggccaaaaga gtgttctccc     4380

ttgagaagaa aatgagtaac tacatacagt tcaagtccaa atgccgtatt gaaccagtat     4440

gtttgctatt gcacgggagt cctggagctg ggaaatcggt tgccaccaac ttaattgggc     4500

gatctctagc tgagaagttg aacagttcag tgtattctct accaccagac cctgaccact     4560

tcgatggcta taaacaacaa gccgttgtga ttatggacga cctatgccaa aatccagatg     4620

ggaaggatgt gtcattattt tgtcagatgg tgtcgagtgt tgactttgtc ccaccaatgg     4680

ctgccttgga agaaaaagga attttgttta cctctccctt tgtcttggcc tcaactaatg     4740

ctggttccat caatgccccg acggtgtcag acagcagggc tttggctaga agattccact     4800

ttgacatgaa catcgaggtt atatcaatgt acagccagaa tggcaagatt aacatgccca     4860

tgtcagtcaa aacatgcgac gaagagtgct gtccagttaa cttcaaaaag tgttgccccc     4920

ttgtgtgtgg aaaagccata cagtttatag atagaagaac tcaagtgagg tactccttgg     4980

acatgttggt cactgagatg tttagggagt acaaccatag gcacagcgtc ggggcaaccc     5040

ttgaggcact atttcaaggt ccaccagtat acagggagat caaaattact gttgcacctg     5100

ataccccacc accaccagct attgcatacc tactgaaatc attggacagt gaagcagtta     5160

gggagtactg taaagagaat ggatggctcg ttcctgaaat tagctctacc cttcatattg     5220

aaaaacatgt aagccgagcc tttatctgtc tccaggcact gacaactttt gtatccgtgg     5280

ccggtattat ctacatcatt tataaactat ttgcagggtt tcaaggcgcc tacacaggga     5340

tgcccaacca aaagccaaaa atacccacac taaggcaagc caaggtgcag ggacctgctt     5400

gtgagtttgc tgtagccatg atgaagagaa actccatcac agtgaagaca gagtatggtg     5460

agtttacaat gttgggcatc tacgacaggt gggccgtact accacgccat gcaaaacccg     5520

ggccaaccat ccttatgaat gaccaggaag ttggcgtact agatgcaaaa gaactagtgg     5580

ataaagatgg cacaaacctt gaactgacgc tgttgaagct tgaccggaat gaaaagttca     5640

gagacatcag aggtttcctg gccaaggaag aagtggaggt caatgaagct gttctagcaa     5700

taaacaccag caagttcccg aacatgtaca taccagttgg gcaagtaaca gactacggtt     5760

tcctgaacct ggggggcact ccgacgaaaa gaatgctcat gtacaatttt cctaccagag     5820

ctggccaatg tggtggtatt cttatgtcta ctggtaaggt gttggggata cacgttggtg     5880

gaaatggcca ccagggcttc tcagcagctc tccttaaaca ctacttcaat gatgaacaag     5940

gtgagattga atttattgaa agctcaaagg aagcaggttt cccagtcatt aatactccaa     6000

gcaagactaa attggaacca agtgtcttcc accaagtgtt tgaaggcaac aaggaacctg     6060

cagttctcag gaatggtgat ccacgactca aagcaaattt tgaggaggca atcttttcca     6120

aatatattgg taatgtgaac acacacgtag atgagtacat gatggaagcc gtggatcact     6180

acgcaggaca attggccaca ctggacatta atacggaacc tatgaaattg gaggatgcag     6240

tgtatggcac agaggggttg gaggcacttg atctaaccac cagtgcaggg tacccgtatg     6300

tagcactggg catcaagaag agagacatct tgtctaagaa gaccagagat ctgactaaat     6360

taaaggagtg tatggacaaa tatggtctaa accttccgat ggtgacctat gtgaaggatg     6420

agctcagatc agcagaaaaa gtggctaaag gcaagtctag acttattgag gcatccagcc     6480

tgaacgactc tgtagcgatg agacaaactt ttggcaatct gtacagaaca tttcatttga     6540

acccagggat tgtaactggc agtgcagttg ggtgtgatcc tgaccttttc tggagcaaaa     6600

tacctgtaat gctagatgga catctcatag cctttgatta ctctggatat gatgccagtt     6660

tgagccccgt gtggtttgct tgtttgaagc tattgctaga aaaactagga tactcacaca     6720

aagaaacaaa ttacattgac tatttgtgca attcccacca tttgtacaga gacaagcatt     6780

acttcgtgcg tggcggcatg ccatcaggtt gctccggtac cagcatcttc aactcaatga     6840

tcaacaacat cataatcagg acgctaatgt tgaaggtgta caaaggaatt gacctggatc     6900

gattcagaat gattgcctat ggcgatgatg ttattgcgtc ttacccctgg ccaatcgatg     6960

cctctttact tgctgaagcc ggcaaggggt atgggctgat catgacacca gcagataaag     7020

gggagtgttt taatgaagtc acctggacta atgtcacctt tttgaagaga tatttcagag     7080

cagatgagca ataccccttt gtggtccatc ctgttatccc aatgaaagac atccatgaat     7140

caattagatg gacaaaagac ccaaagaaca cccaagacca tgtgcgctct ttgtgcttgt     7200

tggcctggca caatggggag cacgaatatg aggaattcat caagaagatc agaagcgtcc     7260

cagtcgggcg ctgtctaacc cttcctgcgt tttggaccct gcgcaggaaa tggttggatt     7320

ccttttagat tagagacaat tttctgcaat ttgaattggc ttaaccctac cacactcacc     7380

gaactagaca acggtgtggt aggggtaaat tctccgcatt cggtgcgg                  7428


<210>  2
<211>  507
<212>  RNA
<213>  ˹

<220>
<223>  HRV2ڲλеRNA

<400>  2
aacuuagaag uuuuucacaa agaccaauag ccgguaauca gccagauuac ugaaggucaa       60

gcacuucugu uuccccgguc aauguugaua ugcuccaaca gggcaaaaac aacugcgauc      120

guuaaccgca aagcgccuac gcaaagcuua guagcaucuu ugaaaucguu uggcuggucg      180

auccgccauu uccccuggua gaccuggcag augaggcuag aaauacccca cuggcgacag      240

uguucuagcc ugcguggcug ccugcacacc cuaugggugu gaagccaaac aauggacaag      300

gugugaagag ccccgugugc ucgcuuugag uccuccggcc ccugaaugug gcuaaccuua      360

acccugcagc uagagcacgu aacccaaugu guaucuaguc guaaugagca auugcgggau      420

gggaccaacu acuuugggug uccguguuuc acuuuuuccu uuauauuugc uuauggugac      480

aauauauaca auauauauau uggcacc                                          507


<210>  3
<211>  22
<212>  RNA
<213>  ˹

<220>
<223>  miR-133еRNA

<400>  3
acagcugguu gaaggggacc aa                                                22


<210>  4
<211>  22
<212>  RNA
<213>  ˹

<220>
<223>  miR-206еRNA

<400>  4
ccacacacuu ccuuacauuc ca                                                22


<210>  5
<211>  102
<212>  RNA
<213>  ˹

<220>
<223>  miR-133miR-206еĴеRNA

<400>  5
acagcugguu gaaggggacc aacgauacag cugguugaag gggaccaaac cgguccacac       60

acuuccuuac auuccaucac ccacacacuu ccuuacauuc ca                         102


<210>  6
<211>  435
<212>  DNA
<213>  ˹

<220>
<223>  GM-CSFDNA

<400>  6
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  7
<211>  795
<212>  DNA
<213>  ˹

<220>
<223>  Anti-PD-1 scFv DNA

<400>  7
atgaagcacc tgtggttctt cctgctgctg gtggccgctc ctaggtgggt gctgtcccag       60

gtgcagctgg tgcagagcgg cgtggaggtg aagaagcccg gcgcttccgt gaaggtgtcc      120

tgcaaggcct ccggctacac cttcaccaac tactacatgt actgggtgag gcaggcccct      180

ggacagggac tggagtggat gggcggcatc aacccttcca acggcggcac caacttcaac      240

gagaagttca agaaccgggt gaccctgacc accgactcct ccaccaccac cgcctacatg      300

gagctgaagt ccctgcagtt tgacgacacc gccgtgtact actgcgccag gagggactac      360

cggttcgaca tgggcttcga ctactggggc cagggcacaa ccgtgaccgt gtccagcgga      420

ggtggcggat ctggaggggg tggtagcggt ggaggcggga gtgagatcgt gctgacccag      480

tcccctgcta cactgtccct gtcccccggc gagagggcta cactgagctg cagggcctcc      540

aagggcgtgt ccacctccgg ctactcctac ctgcactggt accagcagaa gcctggacag      600

gctcccaggc tgctgatcta cctggcctcc tacctggagt ccggcgtgcc tgctaggttt      660

tccggcagcg gcagcggcac cgatttcacc ctgaccatct cctccctgga gcccgaggac      720

ttcgccgtgt actactgcca gcactccagg gatctgcctc tgaccttcgg cggcggcacc      780

aaggtggaga tcaag                                                       795


<210>  8
<211>  7309
<212>  DNA
<213>  ˹

<220>
<223>  ECHO25-HRV2cDNA

<400>  8
ttaaaacagc ctgtgggttg ttcccaccca tagggcccac tgggcgctag cacactggta       60

ttgtggtacc tttgtgcgcc tgttttatct acccctcccc caaacgtgac ttagaagaac      120

ttagaagttt ttcacaaaga ccaatagccg gtaatcagcc agattactga aggtcaagca      180

cttctgtttc cccggtcaat gttgatatgc tccaacaggg caaaaacaac tgcgatcgtt      240

aaccgcaaag cgcctacgca aagcttagta gcatctttga aatcgtttgg ctggtcgatc      300

cgccatttcc cctggtagac ctggcagatg aggctagaaa taccccactg gcgacagtgt      360

tctagcctgc gtggctgcct gcacacccta tgggtgtgaa gccaaacaat ggacaaggtg      420

tgaagagccc cgtgtgctcg ctttgagtcc tccggcccct gaatgtggct aaccttaacc      480

ctgcagctag agcacgtaac ccaatgtgta tctagtcgta atgagcaatt gcgggatggg      540

accaactact ttgggtgtcc gtgtttcact ttttccttta tatttgctta tggtgacaat      600

atatacaata tatatattgg caccatggga gctcatgtgt caacgcagaa aaccggagcg      660

catgagactg gtttgagcgc cagtgggaat tcggttattc attacacaac atcaattatt      720

acaaggatgc atcttcaaat tcagcaaaca ggcaagactt ttcacaagac cccagcaaat      780

ttaccgaacc ctatgaagga tgtcatgatt aaatcactcc cggcgttaaa ttcacccact      840

gtggaggaat gtggctacag tgaccgggtg cgctccatta ctttgggtaa ttcaacaatc      900

actacgcagg aaagtgcaaa tgtggtagtt ggctatggtg tctggccgga gtatttgagg      960

gatgaggaag ccacggcaca agaccaaccc actcaaccag atgttgccac ctgtagattc     1020

tacaccctag aatctgttat gtgggagaag tcctcggcgg gctggtggtg gaagtttcca     1080

gatgctcttg cagagatggg cctattcggt caaaatatgc tataccatta tttgggaagg     1140

tcaggctaca caatacacgt gcaatgcaat gcgtcaaaat tccaccaagg gtgccttctt     1200

gtagtctgtg tgccagaagc cgagatgggt tctgcacagc ttgataggac attgaatcat     1260

accaaactta gcaacacaga acacgccagc acattcgggt ccatgagttc caatgaagct     1320

ggggccgtcc aaaatgtagt gcacaatgcc gggatgggcg ttggagtggg taacttgacc     1380

atctaccctc atcagtggat taatcttaga accaacaatt gtgccaccat agtaatgccg     1440

tacataaaca gtgtgccaat ggataatatg tttaggcatt acaatttcac ccttatggtg     1500

attccattcg cacagcttga ttatgcaccc agcgcgtcca ctcacgttcc aataaccgtg     1560

acagttgccc ccatgtgtgc cgaatacaac gggctaagat tggcaggtaa acagggctta     1620

ccaacaatgc tcactccagg tagcaaccag ttcctcacgt ctgatgattt ccagtcccca     1680

tcagcaatgc cacagtttga tgtaacgccg gagattgaaa tccccggtga cgtgaagaat     1740

ttaatggaaa tggctgaagt tgattctgtg gtcccagtga ataatctgga tgataaggta     1800

aattcaattg aagcttatac aatccccgtc aaatcaatga gtggtattgc gacacaagtc     1860

gttgggttcc aattacaacc cggggacgat agtgcgttta agaggacact gttaggagag     1920

attttgaact actttgcaaa ttggtcggga attatcaaac tgacattccc atactgcggt     1980

gcggcgatga ccactggcac attcctgatc gcctactccc ctcctggtgc tggcttccct     2040

gctaaccgca aggactcaat gttgggcact cacattgtct gggacatagg attgcaatcg     2100

agttgtgtgc tctgcgtgcc atggatcagt cagacaaact accgcttcgt gacgcatgac     2160

gcttatacag acgctgggtt tattacatgc tggtaccaaa caaacatagt gtcaccccca     2220

gacatcccgg cagacagtac aatcctatgt tttgtttcag cttgtaatga tttctcggtg     2280

cgcttgttaa gggacacgcc attcatatca caaaacgcac ttctccaaaa tgacccggct     2340

actgccattg ttagatcagt ggaacgggtg gccgatacca tagcaagtgg cccaatgaat     2400

tccgagagag tcccagcatt gactgccgtc gagacgggtc acacatctca agttgttccc     2460

agtgatacta tgcaaaccag gcatgttgtt aaccatcaca ttagatcgga atcttcaata     2520

gagaattttc tgagtagatc ggcatgcgtt tacattgatg tgtatggcac aaaagagaat     2580

ggtgacatcg aacgtttcac taactggaag atcaacacac gccaggttgt tcagctgagg     2640

cgcaagctgg agatgttcac ttacatcaga tttgatgtgg aaataacatt cgtaattaca     2700

agtactcaag ggacatcaac ccaaacaagc actggcaccc cagtgctcac acatcaagtg     2760

atgtatgtgc cacccggagg ccccataccc gcgtcatatg aggattatag ctggcaaact     2820

tcgacaaacc ccagcgtttt ctggacagaa gggaatgcac cggctcgcat gtcaataccc     2880

tttatgagtg tgggcaatgc ctattgcaac ttttatgatg gctggtcaca tttctcgcaa     2940

tccggcgtgt atggtttcac taccctgaac aacatgggac agctgttttt cagacatgtg     3000

aataaggaca cacttggccc ttacaacagc acagtgcgtg tctatttcaa accaaagcac     3060

atcaaagcat gggtgcccag accaccgcgt ctatgcgatt atgtgtatgc acataatgtc     3120

gatttcaccc ccagaggagt cacggacata agggaaaaga tcacactgga aagagacgac     3180

cacacgcctt cgatggtaaa ccacggtgct tttggacagc agtctggcgc catttacgtg     3240

ggtaactaca gagtggtaaa taggcacctg gccacctatg ccgattggca gaattgcgtg     3300

tgggaagatt ataatagaga cctcttagtg agcacaacca cagcgcacgg gtgtgacacc     3360

atcgctaggt gtcaatgctg cacgggtgtc tacttttgtg cctcaaggaa caagcactac     3420

ccagttagct ttgaagggcc aggcctagtg gaagttcagg agagtgagta ttacccaaag     3480

agataccagt cccacgtgct gttagccgca gggttttctg aaccaggaga ctgtggtgga     3540

attctcaggt gcgagcatgg tgttatcgga ctagttacca tgggtggcga aggcgtagtc     3600

ggctttgctg atgtgcgcga cctgctgtgg ttggaggatg atgcaatgga acaaggggtc     3660

aagggttatg tagaacaatt gggcaatgcc ttcggttccg ggttcaccaa tcaaatctgc     3720

gaacaagtca acctcctcaa agaatcacta gtgggccaag attccatact agagaagtcc     3780

cttaaagctc ttgtgaaaat catttcagca ctggtaatag tagtgaggaa ccatgatgac     3840

ttaattactg tgactgccac cctcgctcta attggctgca cctcatcgcc gtggcggtgg     3900

cttaaacaga aggtgtcaca gtattacggg atacccatgg ctgagcgaca aaacaacggg     3960

tggctcaaaa agtttacaga gatgaccaat gcctgcaaag ggatggagtg gattgccgtc     4020

aagatccaaa agtttataga atggctcaag attaaaatct taccagaggt aaaggagaag     4080

catgagttcc taaccagact taaacaactc ccccttctgg aaagccaaat tgccaccatt     4140

gaacaaagtg caccgtccca gagtgatcag gaacaactct tctcaaatgt tcaatacttc     4200

gcccactact gcagaaagta cgcacctctg tatgctactg aggccaaaag agtgttctcc     4260

cttgagaaga aaatgagtaa ctacatacag ttcaagtcca aatgccgtat tgaaccagta     4320

tgtttgctat tgcacgggag tcctggagct gggaaatcgg ttgccaccaa cttaattggg     4380

cgatctctag ctgagaagtt gaacagttca gtgtattctc taccaccaga ccctgaccac     4440

ttcgatggct ataaacaaca agccgttgtg attatggacg acctatgcca aaatccagat     4500

gggaaggatg tgtcattatt ttgtcagatg gtgtcgagtg ttgactttgt cccaccaatg     4560

gctgccttgg aagaaaaagg aattttgttt acctctccct ttgtcttggc ctcaactaat     4620

gctggttcca tcaatgcccc gacggtgtca gacagcaggg ctttggctag aagattccac     4680

tttgacatga acatcgaggt tatatcaatg tacagccaga atggcaagat taacatgccc     4740

atgtcagtca aaacatgcga cgaagagtgc tgtccagtta acttcaaaaa gtgttgcccc     4800

cttgtgtgtg gaaaagccat acagtttata gatagaagaa ctcaagtgag gtactccttg     4860

gacatgttgg tcactgagat gtttagggag tacaaccata ggcacagcgt cggggcaacc     4920

cttgaggcac tatttcaagg tccaccagta tacagggaga tcaaaattac tgttgcacct     4980

gataccccac caccaccagc tattgcatac ctactgaaat cattggacag tgaagcagtt     5040

agggagtact gtaaagagaa tggatggctc gttcctgaaa ttagctctac ccttcatatt     5100

gaaaaacatg taagccgagc ctttatctgt ctccaggcac tgacaacttt tgtatccgtg     5160

gccggtatta tctacatcat ttataaacta tttgcagggt ttcaaggcgc ctacacaggg     5220

atgcccaacc aaaagccaaa aatacccaca ctaaggcaag ccaaggtgca gggacctgct     5280

tgtgagtttg ctgtagccat gatgaagaga aactccatca cagtgaagac agagtatggt     5340

gagtttacaa tgttgggcat ctacgacagg tgggccgtac taccacgcca tgcaaaaccc     5400

gggccaacca tccttatgaa tgaccaggaa gttggcgtac tagatgcaaa agaactagtg     5460

gataaagatg gcacaaacct tgaactgacg ctgttgaagc ttgaccggaa tgaaaagttc     5520

agagacatca gaggtttcct ggccaaggaa gaagtggagg tcaatgaagc tgttctagca     5580

ataaacacca gcaagttccc gaacatgtac ataccagttg ggcaagtaac agactacggt     5640

ttcctgaacc tggggggcac tccgacgaaa agaatgctca tgtacaattt tcctaccaga     5700

gctggccaat gtggtggtat tcttatgtct actggtaagg tgttggggat acacgttggt     5760

ggaaatggcc accagggctt ctcagcagct ctccttaaac actacttcaa tgatgaacaa     5820

ggtgagattg aatttattga aagctcaaag gaagcaggtt tcccagtcat taatactcca     5880

agcaagacta aattggaacc aagtgtcttc caccaagtgt ttgaaggcaa caaggaacct     5940

gcagttctca ggaatggtga tccacgactc aaagcaaatt ttgaggaggc aatcttttcc     6000

aaatatattg gtaatgtgaa cacacacgta gatgagtaca tgatggaagc cgtggatcac     6060

tacgcaggac aattggccac actggacatt aatacggaac ctatgaaatt ggaggatgca     6120

gtgtatggca cagaggggtt ggaggcactt gatctaacca ccagtgcagg gtacccgtat     6180

gtagcactgg gcatcaagaa gagagacatc ttgtctaaga agaccagaga tctgactaaa     6240

ttaaaggagt gtatggacaa atatggtcta aaccttccga tggtgaccta tgtgaaggat     6300

gagctcagat cagcagaaaa agtggctaaa ggcaagtcta gacttattga ggcatccagc     6360

ctgaacgact ctgtagcgat gagacaaact tttggcaatc tgtacagaac atttcatttg     6420

aacccaggga ttgtaactgg cagtgcagtt gggtgtgatc ctgacctttt ctggagcaaa     6480

atacctgtaa tgctagatgg acatctcata gcctttgatt actctggata tgatgccagt     6540

ttgagccccg tgtggtttgc ttgtttgaag ctattgctag aaaaactagg atactcacac     6600

aaagaaacaa attacattga ctatttgtgc aattcccacc atttgtacag agacaagcat     6660

tacttcgtgc gtggcggcat gccatcaggt tgctccggta ccagcatctt caactcaatg     6720

atcaacaaca tcataatcag gacgctaatg ttgaaggtgt acaaaggaat tgacctggat     6780

cgattcagaa tgattgccta tggcgatgat gttattgcgt cttacccctg gccaatcgat     6840

gcctctttac ttgctgaagc cggcaagggg tatgggctga tcatgacacc agcagataaa     6900

ggggagtgtt ttaatgaagt cacctggact aatgtcacct ttttgaagag atatttcaga     6960

gcagatgagc aatacccctt tgtggtccat cctgttatcc caatgaaaga catccatgaa     7020

tcaattagat ggacaaaaga cccaaagaac acccaagacc atgtgcgctc tttgtgcttg     7080

ttggcctggc acaatgggga gcacgaatat gaggaattca tcaagaagat cagaagcgtc     7140

ccagtcgggc gctgtctaac ccttcctgcg ttttggaccc tgcgcaggaa atggttggat     7200

tccttttaga ttagagacaa ttttctgcaa tttgaattgg cttaacccta ccacactcac     7260

cgaactagac aacggtgtgg taggggtaaa ttctccgcat tcggtgcgg                 7309


<210>  9
<211>  7530
<212>  DNA
<213>  ˹

<220>
<223>  ECHO25-miR133&206TcDNA

<400>  9
ttaaaacagc ctgtgggttg ttcccaccca tagggcccac tgggcgctag cacactggta       60

ttgtggtacc tttgtgcgcc tgttttatct acccctcccc caaacgtgac ttagaagctc      120

aacacatgtg gtcagcaggt ggcccagtat accaactggg tcttgatcaa gcacttctgt      180

taccccggac cgagtatcaa taggctgctc acgcggctga aggagaaagt gttcgttatc      240

cggccaatta ctacgagaaa cctagtacca ccatggaagt tgcgcggcgt ttcgctccgc      300

acaaccccag tgtagatcag gccgatgagt caccgcactc ctcacgggcg accgtggcgg      360

tggctgcgct ggcggcctgc ccatggggca acccatggga cgcttcaata ccgacatggt      420

gtgaagagtc tattgtgcta attggtaatc ctccggcccc tgaatgcggc taatcccaac      480

tgcggagcag atacccacat gccagtgggc agtctgtcgt aacgggtaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttctt tttattcttt attggctgct tatggtgaca      600

attgagagat tgttgccata tagctattgg attggccatc cggtgacaaa cagaacaata      660

gtttatctat ttgttggttt cataccatta aattttaaag tattaaagac tatcaacttg      720

atcatactac ttaatacagc aaaatgggag ctcatgtgtc aacgcagaaa accggagcgc      780

atgagactgg tttgagcgcc agtgggaatt cggttattca ttacacaaca tcaattatta      840

caaggatgca tcttcaaatt cagcaaacag gcaagacttt tcacaagacc ccagcaaatt      900

taccgaaccc tatgaaggat gtcatgatta aatcactccc ggcgttaaat tcacccactg      960

tggaggaatg tggctacagt gaccgggtgc gctccattac tttgggtaat tcaacaatca     1020

ctacgcagga aagtgcaaat gtggtagttg gctatggtgt ctggccggag tatttgaggg     1080

atgaggaagc cacggcacaa gaccaaccca ctcaaccaga tgttgccacc tgtagattct     1140

acaccctaga atctgttatg tgggagaagt cctcggcggg ctggtggtgg aagtttccag     1200

atgctcttgc agagatgggc ctattcggtc aaaatatgct ataccattat ttgggaaggt     1260

caggctacac aatacacgtg caatgcaatg cgtcaaaatt ccaccaaggg tgccttcttg     1320

tagtctgtgt gccagaagcc gagatgggtt ctgcacagct tgataggaca ttgaatcata     1380

ccaaacttag caacacagaa cacgccagca cattcgggtc catgagttcc aatgaagctg     1440

gggccgtcca aaatgtagtg cacaatgccg ggatgggcgt tggagtgggt aacttgacca     1500

tctaccctca tcagtggatt aatcttagaa ccaacaattg tgccaccata gtaatgccgt     1560

acataaacag tgtgccaatg gataatatgt ttaggcatta caatttcacc cttatggtga     1620

ttccattcgc acagcttgat tatgcaccca gcgcgtccac tcacgttcca ataaccgtga     1680

cagttgcccc catgtgtgcc gaatacaacg ggctaagatt ggcaggtaaa cagggcttac     1740

caacaatgct cactccaggt agcaaccagt tcctcacgtc tgatgatttc cagtccccat     1800

cagcaatgcc acagtttgat gtaacgccgg agattgaaat ccccggtgac gtgaagaatt     1860

taatggaaat ggctgaagtt gattctgtgg tcccagtgaa taatctggat gataaggtaa     1920

attcaattga agcttataca atccccgtca aatcaatgag tggtattgcg acacaagtcg     1980

ttgggttcca attacaaccc ggggacgata gtgcgtttaa gaggacactg ttaggagaga     2040

ttttgaacta ctttgcaaat tggtcgggaa ttatcaaact gacattccca tactgcggtg     2100

cggcgatgac cactggcaca ttcctgatcg cctactcccc tcctggtgct ggcttccctg     2160

ctaaccgcaa ggactcaatg ttgggcactc acattgtctg ggacatagga ttgcaatcga     2220

gttgtgtgct ctgcgtgcca tggatcagtc agacaaacta ccgcttcgtg acgcatgacg     2280

cttatacaga cgctgggttt attacatgct ggtaccaaac aaacatagtg tcacccccag     2340

acatcccggc agacagtaca atcctatgtt ttgtttcagc ttgtaatgat ttctcggtgc     2400

gcttgttaag ggacacgcca ttcatatcac aaaacgcact tctccaaaat gacccggcta     2460

ctgccattgt tagatcagtg gaacgggtgg ccgataccat agcaagtggc ccaatgaatt     2520

ccgagagagt cccagcattg actgccgtcg agacgggtca cacatctcaa gttgttccca     2580

gtgatactat gcaaaccagg catgttgtta accatcacat tagatcggaa tcttcaatag     2640

agaattttct gagtagatcg gcatgcgttt acattgatgt gtatggcaca aaagagaatg     2700

gtgacatcga acgtttcact aactggaaga tcaacacacg ccaggttgtt cagctgaggc     2760

gcaagctgga gatgttcact tacatcagat ttgatgtgga aataacattc gtaattacaa     2820

gtactcaagg gacatcaacc caaacaagca ctggcacccc agtgctcaca catcaagtga     2880

tgtatgtgcc acccggaggc cccatacccg cgtcatatga ggattatagc tggcaaactt     2940

cgacaaaccc cagcgttttc tggacagaag ggaatgcacc ggctcgcatg tcaataccct     3000

ttatgagtgt gggcaatgcc tattgcaact tttatgatgg ctggtcacat ttctcgcaat     3060

ccggcgtgta tggtttcact accctgaaca acatgggaca gctgtttttc agacatgtga     3120

ataaggacac acttggccct tacaacagca cagtgcgtgt ctatttcaaa ccaaagcaca     3180

tcaaagcatg ggtgcccaga ccaccgcgtc tatgcgatta tgtgtatgca cataatgtcg     3240

atttcacccc cagaggagtc acggacataa gggaaaagat cacactggaa agagacgacc     3300

acacgccttc gatggtaaac cacggtgctt ttggacagca gtctggcgcc atttacgtgg     3360

gtaactacag agtggtaaat aggcacctgg ccacctatgc cgattggcag aattgcgtgt     3420

gggaagatta taatagagac ctcttagtga gcacaaccac agcgcacggg tgtgacacca     3480

tcgctaggtg tcaatgctgc acgggtgtct acttttgtgc ctcaaggaac aagcactacc     3540

cagttagctt tgaagggcca ggcctagtgg aagttcagga gagtgagtat tacccaaaga     3600

gataccagtc ccacgtgctg ttagccgcag ggttttctga accaggagac tgtggtggaa     3660

ttctcaggtg cgagcatggt gttatcggac tagttaccat gggtggcgaa ggcgtagtcg     3720

gctttgctga tgtgcgcgac ctgctgtggt tggaggatga tgcaatggaa caaggggtca     3780

agggttatgt agaacaattg ggcaatgcct tcggttccgg gttcaccaat caaatctgcg     3840

aacaagtcaa cctcctcaaa gaatcactag tgggccaaga ttccatacta gagaagtccc     3900

ttaaagctct tgtgaaaatc atttcagcac tggtaatagt agtgaggaac catgatgact     3960

taattactgt gactgccacc ctcgctctaa ttggctgcac ctcatcgccg tggcggtggc     4020

ttaaacagaa ggtgtcacag tattacggga tacccatggc tgagcgacaa aacaacgggt     4080

ggctcaaaaa gtttacagag atgaccaatg cctgcaaagg gatggagtgg attgccgtca     4140

agatccaaaa gtttatagaa tggctcaaga ttaaaatctt accagaggta aaggagaagc     4200

atgagttcct aaccagactt aaacaactcc cccttctgga aagccaaatt gccaccattg     4260

aacaaagtgc accgtcccag agtgatcagg aacaactctt ctcaaatgtt caatacttcg     4320

cccactactg cagaaagtac gcacctctgt atgctactga ggccaaaaga gtgttctccc     4380

ttgagaagaa aatgagtaac tacatacagt tcaagtccaa atgccgtatt gaaccagtat     4440

gtttgctatt gcacgggagt cctggagctg ggaaatcggt tgccaccaac ttaattgggc     4500

gatctctagc tgagaagttg aacagttcag tgtattctct accaccagac cctgaccact     4560

tcgatggcta taaacaacaa gccgttgtga ttatggacga cctatgccaa aatccagatg     4620

ggaaggatgt gtcattattt tgtcagatgg tgtcgagtgt tgactttgtc ccaccaatgg     4680

ctgccttgga agaaaaagga attttgttta cctctccctt tgtcttggcc tcaactaatg     4740

ctggttccat caatgccccg acggtgtcag acagcagggc tttggctaga agattccact     4800

ttgacatgaa catcgaggtt atatcaatgt acagccagaa tggcaagatt aacatgccca     4860

tgtcagtcaa aacatgcgac gaagagtgct gtccagttaa cttcaaaaag tgttgccccc     4920

ttgtgtgtgg aaaagccata cagtttatag atagaagaac tcaagtgagg tactccttgg     4980

acatgttggt cactgagatg tttagggagt acaaccatag gcacagcgtc ggggcaaccc     5040

ttgaggcact atttcaaggt ccaccagtat acagggagat caaaattact gttgcacctg     5100

ataccccacc accaccagct attgcatacc tactgaaatc attggacagt gaagcagtta     5160

gggagtactg taaagagaat ggatggctcg ttcctgaaat tagctctacc cttcatattg     5220

aaaaacatgt aagccgagcc tttatctgtc tccaggcact gacaactttt gtatccgtgg     5280

ccggtattat ctacatcatt tataaactat ttgcagggtt tcaaggcgcc tacacaggga     5340

tgcccaacca aaagccaaaa atacccacac taaggcaagc caaggtgcag ggacctgctt     5400

gtgagtttgc tgtagccatg atgaagagaa actccatcac agtgaagaca gagtatggtg     5460

agtttacaat gttgggcatc tacgacaggt gggccgtact accacgccat gcaaaacccg     5520

ggccaaccat ccttatgaat gaccaggaag ttggcgtact agatgcaaaa gaactagtgg     5580

ataaagatgg cacaaacctt gaactgacgc tgttgaagct tgaccggaat gaaaagttca     5640

gagacatcag aggtttcctg gccaaggaag aagtggaggt caatgaagct gttctagcaa     5700

taaacaccag caagttcccg aacatgtaca taccagttgg gcaagtaaca gactacggtt     5760

tcctgaacct ggggggcact ccgacgaaaa gaatgctcat gtacaatttt cctaccagag     5820

ctggccaatg tggtggtatt cttatgtcta ctggtaaggt gttggggata cacgttggtg     5880

gaaatggcca ccagggcttc tcagcagctc tccttaaaca ctacttcaat gatgaacaag     5940

gtgagattga atttattgaa agctcaaagg aagcaggttt cccagtcatt aatactccaa     6000

gcaagactaa attggaacca agtgtcttcc accaagtgtt tgaaggcaac aaggaacctg     6060

cagttctcag gaatggtgat ccacgactca aagcaaattt tgaggaggca atcttttcca     6120

aatatattgg taatgtgaac acacacgtag atgagtacat gatggaagcc gtggatcact     6180

acgcaggaca attggccaca ctggacatta atacggaacc tatgaaattg gaggatgcag     6240

tgtatggcac agaggggttg gaggcacttg atctaaccac cagtgcaggg tacccgtatg     6300

tagcactggg catcaagaag agagacatct tgtctaagaa gaccagagat ctgactaaat     6360

taaaggagtg tatggacaaa tatggtctaa accttccgat ggtgacctat gtgaaggatg     6420

agctcagatc agcagaaaaa gtggctaaag gcaagtctag acttattgag gcatccagcc     6480

tgaacgactc tgtagcgatg agacaaactt ttggcaatct gtacagaaca tttcatttga     6540

acccagggat tgtaactggc agtgcagttg ggtgtgatcc tgaccttttc tggagcaaaa     6600

tacctgtaat gctagatgga catctcatag cctttgatta ctctggatat gatgccagtt     6660

tgagccccgt gtggtttgct tgtttgaagc tattgctaga aaaactagga tactcacaca     6720

aagaaacaaa ttacattgac tatttgtgca attcccacca tttgtacaga gacaagcatt     6780

acttcgtgcg tggcggcatg ccatcaggtt gctccggtac cagcatcttc aactcaatga     6840

tcaacaacat cataatcagg acgctaatgt tgaaggtgta caaaggaatt gacctggatc     6900

gattcagaat gattgcctat ggcgatgatg ttattgcgtc ttacccctgg ccaatcgatg     6960

cctctttact tgctgaagcc ggcaaggggt atgggctgat catgacacca gcagataaag     7020

gggagtgttt taatgaagtc acctggacta atgtcacctt tttgaagaga tatttcagag     7080

cagatgagca ataccccttt gtggtccatc ctgttatccc aatgaaagac atccatgaat     7140

caattagatg gacaaaagac ccaaagaaca cccaagacca tgtgcgctct ttgtgcttgt     7200

tggcctggca caatggggag cacgaatatg aggaattcat caagaagatc agaagcgtcc     7260

cagtcgggcg ctgtctaacc cttcctgcgt tttggaccct gcgcaggaaa tggttggatt     7320

ccttttagat tagagacaca gctggttgaa ggggaccaac gatacagctg gttgaagggg     7380

accaaaccgg tccacacact tccttacatt ccatcaccca cacacttcct tacattccaa     7440

attttctgca atttgaattg gcttaaccct accacactca ccgaactaga caacggtgtg     7500

gtaggggtaa attctccgca ttcggtgcgg                                      7530


<210>  10
<211>  7905
<212>  DNA
<213>  ˹

<220>
<223>  ECHO25-GM-CSFcDNA

<400>  10
ttaaaacagc ctgtgggttg ttcccaccca tagggcccac tgggcgctag cacactggta       60

ttgtggtacc tttgtgcgcc tgttttatct acccctcccc caaacgtgac ttagaagctc      120

aacacatgtg gtcagcaggt ggcccagtat accaactggg tcttgatcaa gcacttctgt      180

taccccggac cgagtatcaa taggctgctc acgcggctga aggagaaagt gttcgttatc      240

cggccaatta ctacgagaaa cctagtacca ccatggaagt tgcgcggcgt ttcgctccgc      300

acaaccccag tgtagatcag gccgatgagt caccgcactc ctcacgggcg accgtggcgg      360

tggctgcgct ggcggcctgc ccatggggca acccatggga cgcttcaata ccgacatggt      420

gtgaagagtc tattgtgcta attggtaatc ctccggcccc tgaatgcggc taatcccaac      480

tgcggagcag atacccacat gccagtgggc agtctgtcgt aacgggtaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttctt tttattcttt attggctgct tatggtgaca      600

attgagagat tgttgccata tagctattgg attggccatc cggtgacaaa cagaacaata      660

gtttatctat ttgttggttt cataccatta aattttaaag tattaaagac tatcaacttg      720

atcatactac ttaatacagc aaaatgggag ctcatgtgtc aacgcagaaa accggagcgc      780

atgagactgg tttgagcgcc agtgggaatt cggttattca ttacacaaca tcaattatta      840

caaggatgca tcttcaaatt cagcaaacag gcaagacttt tcacaagacc ccagcaaatt      900

taccgaaccc tatgaaggat gtcatgatta aatcactccc ggcgttaaat tcacccactg      960

tggaggaatg tggctacagt gaccgggtgc gctccattac tttgggtaat tcaacaatca     1020

ctacgcagga aagtgcaaat gtggtagttg gctatggtgt ctggccggag tatttgaggg     1080

atgaggaagc cacggcacaa gaccaaccca ctcaaccaga tgttgccacc tgtagattct     1140

acaccctaga atctgttatg tgggagaagt cctcggcggg ctggtggtgg aagtttccag     1200

atgctcttgc agagatgggc ctattcggtc aaaatatgct ataccattat ttgggaaggt     1260

caggctacac aatacacgtg caatgcaatg cgtcaaaatt ccaccaaggg tgccttcttg     1320

tagtctgtgt gccagaagcc gagatgggtt ctgcacagct tgataggaca ttgaatcata     1380

ccaaacttag caacacagaa cacgccagca cattcgggtc catgagttcc aatgaagctg     1440

gggccgtcca aaatgtagtg cacaatgccg ggatgggcgt tggagtgggt aacttgacca     1500

tctaccctca tcagtggatt aatcttagaa ccaacaattg tgccaccata gtaatgccgt     1560

acataaacag tgtgccaatg gataatatgt ttaggcatta caatttcacc cttatggtga     1620

ttccattcgc acagcttgat tatgcaccca gcgcgtccac tcacgttcca ataaccgtga     1680

cagttgcccc catgtgtgcc gaatacaacg ggctaagatt ggcaggtaaa cagggcttac     1740

caacaatgct cactccaggt agcaaccagt tcctcacgtc tgatgatttc cagtccccat     1800

cagcaatgcc acagtttgat gtaacgccgg agattgaaat ccccggtgac gtgaagaatt     1860

taatggaaat ggctgaagtt gattctgtgg tcccagtgaa taatctggat gataaggtaa     1920

attcaattga agcttataca atccccgtca aatcaatgag tggtattgcg acacaagtcg     1980

ttgggttcca attacaaccc ggggacgata gtgcgtttaa gaggacactg ttaggagaga     2040

ttttgaacta ctttgcaaat tggtcgggaa ttatcaaact gacattccca tactgcggtg     2100

cggcgatgac cactggcaca ttcctgatcg cctactcccc tcctggtgct ggcttccctg     2160

ctaaccgcaa ggactcaatg ttgggcactc acattgtctg ggacatagga ttgcaatcga     2220

gttgtgtgct ctgcgtgcca tggatcagtc agacaaacta ccgcttcgtg acgcatgacg     2280

cttatacaga cgctgggttt attacatgct ggtaccaaac aaacatagtg tcacccccag     2340

acatcccggc agacagtaca atcctatgtt ttgtttcagc ttgtaatgat ttctcggtgc     2400

gcttgttaag ggacacgcca ttcatatcac aaaacgcact tctccaaaat gacccggcta     2460

ctgccattgt tagatcagtg gaacgggtgg ccgataccat agcaagtggc ccaatgaatt     2520

ccgagagagt cccagcattg actgccgtcg agacgggtca cacatctcaa gttgttccca     2580

gtgatactat gcaaaccagg catgttgtta accatcacat tagatcggaa tcttcaatag     2640

agaattttct gagtagatcg gcatgcgttt acattgatgt gtatggcaca aaagagaatg     2700

gtgacatcga acgtttcact aactggaaga tcaacacacg ccaggttgtt cagctgaggc     2760

gcaagctgga gatgttcact tacatcagat ttgatgtgga aataacattc gtaattacaa     2820

gtactcaagg gacatcaacc caaacaagca ctggcacccc agtgctcaca catcaagtga     2880

tgtatgtgcc acccggaggc cccatacccg cgtcatatga ggattatagc tggcaaactt     2940

cgacaaaccc cagcgttttc tggacagaag ggaatgcacc ggctcgcatg tcaataccct     3000

ttatgagtgt gggcaatgcc tattgcaact tttatgatgg ctggtcacat ttctcgcaat     3060

ccggcgtgta tggtttcact accctgaaca acatgggaca gctgtttttc agacatgtga     3120

ataaggacac acttggccct tacaacagca cagtgcgtgt ctatttcaaa ccaaagcaca     3180

tcaaagcatg ggtgcccaga ccaccgcgtc tatgcgatta tgtgtatgca cataatgtcg     3240

atttcacccc cagaggagtc acggacataa gggaaaagat cacactggaa agagacgacc     3300

acacgccttc gatggtaaac cacggtgctt ttggacagca gtggctgcag agcctgctgc     3360

tcttgggcac tgtggcctgc agcatctctg cacccgcccg ctcgcccagc cccagcacgc     3420

agccctggga gcatgtgaat gccatccagg aggcccggcg tctcctgaac ctgagtagag     3480

acactgctgc tgagatgaat gaaacagtag aagtcatctc agaaatgttt gacctccagg     3540

agccgacctg cctacagacc cgcctggagc tgtacaagca gggcctgcgg ggcagcctca     3600

ccaagctcaa gggccccttg accatgatgg ccagccacta caagcagcac tgccctccaa     3660

ccccggaaac ttcctgtgca acccagatta tcacctttga aagtttcaaa gagaacctga     3720

aggactttct gcttgtcatc ccctttgact gctgggagcc agtccaggag gacgaccaca     3780

cgccttcgat ggtaaaccac ggtgcttttg gacagcagtc tggcgccatt tacgtgggta     3840

actacagagt ggtaaatagg cacctggcca cctatgccga ttggcagaat tgcgtgtggg     3900

aagattataa tagagacctc ttagtgagca caaccacagc gcacgggtgt gacaccatcg     3960

ctaggtgtca atgctgcacg ggtgtctact tttgtgcctc aaggaacaag cactacccag     4020

ttagctttga agggccaggc ctagtggaag ttcaggagag tgagtattac ccaaagagat     4080

accagtccca cgtgctgtta gccgcagggt tttctgaacc aggagactgt ggtggaattc     4140

tcaggtgcga gcatggtgtt atcggactag ttaccatggg tggcgaaggc gtagtcggct     4200

ttgctgatgt gcgcgacctg ctgtggttgg aggatgatgc aatggaacaa ggggtcaagg     4260

gttatgtaga acaattgggc aatgccttcg gttccgggtt caccaatcaa atctgcgaac     4320

aagtcaacct cctcaaagaa tcactagtgg gccaagattc catactagag aagtccctta     4380

aagctcttgt gaaaatcatt tcagcactgg taatagtagt gaggaaccat gatgacttaa     4440

ttactgtgac tgccaccctc gctctaattg gctgcacctc atcgccgtgg cggtggctta     4500

aacagaaggt gtcacagtat tacgggatac ccatggctga gcgacaaaac aacgggtggc     4560

tcaaaaagtt tacagagatg accaatgcct gcaaagggat ggagtggatt gccgtcaaga     4620

tccaaaagtt tatagaatgg ctcaagatta aaatcttacc agaggtaaag gagaagcatg     4680

agttcctaac cagacttaaa caactccccc ttctggaaag ccaaattgcc accattgaac     4740

aaagtgcacc gtcccagagt gatcaggaac aactcttctc aaatgttcaa tacttcgccc     4800

actactgcag aaagtacgca cctctgtatg ctactgaggc caaaagagtg ttctcccttg     4860

agaagaaaat gagtaactac atacagttca agtccaaatg ccgtattgaa ccagtatgtt     4920

tgctattgca cgggagtcct ggagctggga aatcggttgc caccaactta attgggcgat     4980

ctctagctga gaagttgaac agttcagtgt attctctacc accagaccct gaccacttcg     5040

atggctataa acaacaagcc gttgtgatta tggacgacct atgccaaaat ccagatggga     5100

aggatgtgtc attattttgt cagatggtgt cgagtgttga ctttgtccca ccaatggctg     5160

ccttggaaga aaaaggaatt ttgtttacct ctccctttgt cttggcctca actaatgctg     5220

gttccatcaa tgccccgacg gtgtcagaca gcagggcttt ggctagaaga ttccactttg     5280

acatgaacat cgaggttata tcaatgtaca gccagaatgg caagattaac atgcccatgt     5340

cagtcaaaac atgcgacgaa gagtgctgtc cagttaactt caaaaagtgt tgcccccttg     5400

tgtgtggaaa agccatacag tttatagata gaagaactca agtgaggtac tccttggaca     5460

tgttggtcac tgagatgttt agggagtaca accataggca cagcgtcggg gcaacccttg     5520

aggcactatt tcaaggtcca ccagtataca gggagatcaa aattactgtt gcacctgata     5580

ccccaccacc accagctatt gcatacctac tgaaatcatt ggacagtgaa gcagttaggg     5640

agtactgtaa agagaatgga tggctcgttc ctgaaattag ctctaccctt catattgaaa     5700

aacatgtaag ccgagccttt atctgtctcc aggcactgac aacttttgta tccgtggccg     5760

gtattatcta catcatttat aaactatttg cagggtttca aggcgcctac acagggatgc     5820

ccaaccaaaa gccaaaaata cccacactaa ggcaagccaa ggtgcaggga cctgcttgtg     5880

agtttgctgt agccatgatg aagagaaact ccatcacagt gaagacagag tatggtgagt     5940

ttacaatgtt gggcatctac gacaggtggg ccgtactacc acgccatgca aaacccgggc     6000

caaccatcct tatgaatgac caggaagttg gcgtactaga tgcaaaagaa ctagtggata     6060

aagatggcac aaaccttgaa ctgacgctgt tgaagcttga ccggaatgaa aagttcagag     6120

acatcagagg tttcctggcc aaggaagaag tggaggtcaa tgaagctgtt ctagcaataa     6180

acaccagcaa gttcccgaac atgtacatac cagttgggca agtaacagac tacggtttcc     6240

tgaacctggg gggcactccg acgaaaagaa tgctcatgta caattttcct accagagctg     6300

gccaatgtgg tggtattctt atgtctactg gtaaggtgtt ggggatacac gttggtggaa     6360

atggccacca gggcttctca gcagctctcc ttaaacacta cttcaatgat gaacaaggtg     6420

agattgaatt tattgaaagc tcaaaggaag caggtttccc agtcattaat actccaagca     6480

agactaaatt ggaaccaagt gtcttccacc aagtgtttga aggcaacaag gaacctgcag     6540

ttctcaggaa tggtgatcca cgactcaaag caaattttga ggaggcaatc ttttccaaat     6600

atattggtaa tgtgaacaca cacgtagatg agtacatgat ggaagccgtg gatcactacg     6660

caggacaatt ggccacactg gacattaata cggaacctat gaaattggag gatgcagtgt     6720

atggcacaga ggggttggag gcacttgatc taaccaccag tgcagggtac ccgtatgtag     6780

cactgggcat caagaagaga gacatcttgt ctaagaagac cagagatctg actaaattaa     6840

aggagtgtat ggacaaatat ggtctaaacc ttccgatggt gacctatgtg aaggatgagc     6900

tcagatcagc agaaaaagtg gctaaaggca agtctagact tattgaggca tccagcctga     6960

acgactctgt agcgatgaga caaacttttg gcaatctgta cagaacattt catttgaacc     7020

cagggattgt aactggcagt gcagttgggt gtgatcctga ccttttctgg agcaaaatac     7080

ctgtaatgct agatggacat ctcatagcct ttgattactc tggatatgat gccagtttga     7140

gccccgtgtg gtttgcttgt ttgaagctat tgctagaaaa actaggatac tcacacaaag     7200

aaacaaatta cattgactat ttgtgcaatt cccaccattt gtacagagac aagcattact     7260

tcgtgcgtgg cggcatgcca tcaggttgct ccggtaccag catcttcaac tcaatgatca     7320

acaacatcat aatcaggacg ctaatgttga aggtgtacaa aggaattgac ctggatcgat     7380

tcagaatgat tgcctatggc gatgatgtta ttgcgtctta cccctggcca atcgatgcct     7440

ctttacttgc tgaagccggc aaggggtatg ggctgatcat gacaccagca gataaagggg     7500

agtgttttaa tgaagtcacc tggactaatg tcaccttttt gaagagatat ttcagagcag     7560

atgagcaata cccctttgtg gtccatcctg ttatcccaat gaaagacatc catgaatcaa     7620

ttagatggac aaaagaccca aagaacaccc aagaccatgt gcgctctttg tgcttgttgg     7680

cctggcacaa tggggagcac gaatatgagg aattcatcaa gaagatcaga agcgtcccag     7740

tcgggcgctg tctaaccctt cctgcgtttt ggaccctgcg caggaaatgg ttggattcct     7800

tttagattag agacaatttt ctgcaatttg aattggctta accctaccac actcaccgaa     7860

ctagacaacg gtgtggtagg ggtaaattct ccgcattcgg tgcgg                     7905


<210>  11
<211>  8271
<212>  DNA
<213>  ˹

<220>
<223>  ECHO25-Anti-PD1cDNA

<400>  11
ttaaaacagc ctgtgggttg ttcccaccca tagggcccac tgggcgctag cacactggta       60

ttgtggtacc tttgtgcgcc tgttttatct acccctcccc caaacgtgac ttagaagctc      120

aacacatgtg gtcagcaggt ggcccagtat accaactggg tcttgatcaa gcacttctgt      180

taccccggac cgagtatcaa taggctgctc acgcggctga aggagaaagt gttcgttatc      240

cggccaatta ctacgagaaa cctagtacca ccatggaagt tgcgcggcgt ttcgctccgc      300

acaaccccag tgtagatcag gccgatgagt caccgcactc ctcacgggcg accgtggcgg      360

tggctgcgct ggcggcctgc ccatggggca acccatggga cgcttcaata ccgacatggt      420

gtgaagagtc tattgtgcta attggtaatc ctccggcccc tgaatgcggc taatcccaac      480

tgcggagcag atacccacat gccagtgggc agtctgtcgt aacgggtaac tctgcagcgg      540

aaccgactac tttgggtgtc cgtgtttctt tttattcttt attggctgct tatggtgaca      600

attgagagat tgttgccata tagctattgg attggccatc cggtgacaaa cagaacaata      660

gtttatctat ttgttggttt cataccatta aattttaaag tattaaagac tatcaacttg      720

atcatactac ttaatacagc aaaatgggag ctcatgtgtc aacgcagaaa accggagcgc      780

atgagactgg tttgagcgcc agtgggaatt cggttattca ttacacaaca tcaattatta      840

caaggatgca tcttcaaatt cagcaaacag gcaagacttt tcacaagacc ccagcaaatt      900

taccgaaccc tatgaaggat gtcatgatta aatcactccc ggcgttaaat tcacccactg      960

tggaggaatg tggctacagt gaccgggtgc gctccattac tttgggtaat tcaacaatca     1020

ctacgcagga aagtgcaaat gtggtagttg gctatggtgt ctggccggag tatttgaggg     1080

atgaggaagc cacggcacaa gaccaaccca ctcaaccaga tgttgccacc tgtagattct     1140

acaccctaga atctgttatg tgggagaagt cctcggcggg ctggtggtgg aagtttccag     1200

atgctcttgc agagatgggc ctattcggtc aaaatatgct ataccattat ttgggaaggt     1260

caggctacac aatacacgtg caatgcaatg cgtcaaaatt ccaccaaggg tgccttcttg     1320

tagtctgtgt gccagaagcc gagatgggtt ctgcacagct tgataggaca ttgaatcata     1380

ccaaacttag caacacagaa cacgccagca cattcgggtc catgagttcc aatgaagctg     1440

gggccgtcca aaatgtagtg cacaatgccg ggatgggcgt tggagtgggt aacttgacca     1500

tctaccctca tcagtggatt aatcttagaa ccaacaattg tgccaccata gtaatgccgt     1560

acataaacag tgtgccaatg gataatatgt ttaggcatta caatttcacc cttatggtga     1620

ttccattcgc acagcttgat tatgcaccca gcgcgtccac tcacgttcca ataaccgtga     1680

cagttgcccc catgtgtgcc gaatacaacg ggctaagatt ggcaggtaaa cagggcttac     1740

caacaatgct cactccaggt agcaaccagt tcctcacgtc tgatgatttc cagtccccat     1800

cagcaatgcc acagtttgat gtaacgccgg agattgaaat ccccggtgac gtgaagaatt     1860

taatggaaat ggctgaagtt gattctgtgg tcccagtgaa taatctggat gataaggtaa     1920

attcaattga agcttataca atccccgtca aatcaatgag tggtattgcg acacaagtcg     1980

ttgggttcca attacaaccc ggggacgata gtgcgtttaa gaggacactg ttaggagaga     2040

ttttgaacta ctttgcaaat tggtcgggaa ttatcaaact gacattccca tactgcggtg     2100

cggcgatgac cactggcaca ttcctgatcg cctactcccc tcctggtgct ggcttccctg     2160

ctaaccgcaa ggactcaatg ttgggcactc acattgtctg ggacatagga ttgcaatcga     2220

gttgtgtgct ctgcgtgcca tggatcagtc agacaaacta ccgcttcgtg acgcatgacg     2280

cttatacaga cgctgggttt attacatgct ggtaccaaac aaacatagtg tcacccccag     2340

acatcccggc agacagtaca atcctatgtt ttgtttcagc ttgtaatgat ttctcggtgc     2400

gcttgttaag ggacacgcca ttcatatcac aaaacgcact tctccaaaat gacccggcta     2460

ctgccattgt tagatcagtg gaacgggtgg ccgataccat agcaagtggc ccaatgaatt     2520

ccgagagagt cccagcattg actgccgtcg agacgggtca cacatctcaa gttgttccca     2580

gtgatactat gcaaaccagg catgttgtta accatcacat tagatcggaa tcttcaatag     2640

agaattttct gagtagatcg gcatgcgttt acattgatgt gtatggcaca aaagagaatg     2700

gtgacatcga acgtttcact aactggaaga tcaacacacg ccaggttgtt cagctgaggc     2760

gcaagctgga gatgttcact tacatcagat ttgatgtgga aataacattc gtaattacaa     2820

gtactcaagg gacatcaacc caaacaagca ctggcacccc agtgctcaca catcaagtga     2880

tgtatgtgcc acccggaggc cccatacccg cgtcatatga ggattatagc tggcaaactt     2940

cgacaaaccc cagcgttttc tggacagaag ggaatgcacc ggctcgcatg tcaataccct     3000

ttatgagtgt gggcaatgcc tattgcaact tttatgatgg ctggtcacat ttctcgcaat     3060

ccggcgtgta tggtttcact accctgaaca acatgggaca gctgtttttc agacatgtga     3120

ataaggacac acttggccct tacaacagca cagtgcgtgt ctatttcaaa ccaaagcaca     3180

tcaaagcatg ggtgcccaga ccaccgcgtc tatgcgatta tgtgtatgca cataatgtcg     3240

atttcacccc cagaggagtc acggacataa gggaaaagat cacactggaa agagacgacc     3300

acacgccttc gatggtaaac cacggtgctt ttggacagca gatgaagcac ctgtggttct     3360

tcctgctgct ggtggccgct cctaggtggg tgctgtccca ggtgcagctg gtgcagagcg     3420

gcgtggaggt gaagaagccc ggcgcttccg tgaaggtgtc ctgcaaggcc tccggctaca     3480

ccttcaccaa ctactacatg tactgggtga ggcaggcccc tggacaggga ctggagtgga     3540

tgggcggcat caacccttcc aacggcggca ccaacttcaa cgagaagttc aagaaccggg     3600

tgaccctgac caccgactcc tccaccacca ccgcctacat ggagctgaag tccctgcagt     3660

ttgacgacac cgccgtgtac tactgcgcca ggagggacta ccggttcgac atgggcttcg     3720

actactgggg ccagggcaca accgtgaccg tgtccagcgg aggtggcgga tctggagggg     3780

gtggtagcgg tggaggcggg agtgagatcg tgctgaccca gtcccctgct acactgtccc     3840

tgtcccccgg cgagagggct acactgagct gcagggcctc caagggcgtg tccacctccg     3900

gctactccta cctgcactgg taccagcaga agcctggaca ggctcccagg ctgctgatct     3960

acctggcctc ctacctggag tccggcgtgc ctgctaggtt ttccggcagc ggcagcggca     4020

ccgatttcac cctgaccatc tcctccctgg agcccgagga cttcgccgtg tactactgcc     4080

agcactccag ggatctgcct ctgaccttcg gcggcggcac caaggtggag atcaaggacg     4140

accacacgcc ttcgatggta aaccacggtg cttttggaca gcagtctggc gccatttacg     4200

tgggtaacta cagagtggta aataggcacc tggccaccta tgccgattgg cagaattgcg     4260

tgtgggaaga ttataataga gacctcttag tgagcacaac cacagcgcac gggtgtgaca     4320

ccatcgctag gtgtcaatgc tgcacgggtg tctacttttg tgcctcaagg aacaagcact     4380

acccagttag ctttgaaggg ccaggcctag tggaagttca ggagagtgag tattacccaa     4440

agagatacca gtcccacgtg ctgttagccg cagggttttc tgaaccagga gactgtggtg     4500

gaattctcag gtgcgagcat ggtgttatcg gactagttac catgggtggc gaaggcgtag     4560

tcggctttgc tgatgtgcgc gacctgctgt ggttggagga tgatgcaatg gaacaagggg     4620

tcaagggtta tgtagaacaa ttgggcaatg ccttcggttc cgggttcacc aatcaaatct     4680

gcgaacaagt caacctcctc aaagaatcac tagtgggcca agattccata ctagagaagt     4740

cccttaaagc tcttgtgaaa atcatttcag cactggtaat agtagtgagg aaccatgatg     4800

acttaattac tgtgactgcc accctcgctc taattggctg cacctcatcg ccgtggcggt     4860

ggcttaaaca gaaggtgtca cagtattacg ggatacccat ggctgagcga caaaacaacg     4920

ggtggctcaa aaagtttaca gagatgacca atgcctgcaa agggatggag tggattgccg     4980

tcaagatcca aaagtttata gaatggctca agattaaaat cttaccagag gtaaaggaga     5040

agcatgagtt cctaaccaga cttaaacaac tcccccttct ggaaagccaa attgccacca     5100

ttgaacaaag tgcaccgtcc cagagtgatc aggaacaact cttctcaaat gttcaatact     5160

tcgcccacta ctgcagaaag tacgcacctc tgtatgctac tgaggccaaa agagtgttct     5220

cccttgagaa gaaaatgagt aactacatac agttcaagtc caaatgccgt attgaaccag     5280

tatgtttgct attgcacggg agtcctggag ctgggaaatc ggttgccacc aacttaattg     5340

ggcgatctct agctgagaag ttgaacagtt cagtgtattc tctaccacca gaccctgacc     5400

acttcgatgg ctataaacaa caagccgttg tgattatgga cgacctatgc caaaatccag     5460

atgggaagga tgtgtcatta ttttgtcaga tggtgtcgag tgttgacttt gtcccaccaa     5520

tggctgcctt ggaagaaaaa ggaattttgt ttacctctcc ctttgtcttg gcctcaacta     5580

atgctggttc catcaatgcc ccgacggtgt cagacagcag ggctttggct agaagattcc     5640

actttgacat gaacatcgag gttatatcaa tgtacagcca gaatggcaag attaacatgc     5700

ccatgtcagt caaaacatgc gacgaagagt gctgtccagt taacttcaaa aagtgttgcc     5760

cccttgtgtg tggaaaagcc atacagttta tagatagaag aactcaagtg aggtactcct     5820

tggacatgtt ggtcactgag atgtttaggg agtacaacca taggcacagc gtcggggcaa     5880

cccttgaggc actatttcaa ggtccaccag tatacaggga gatcaaaatt actgttgcac     5940

ctgatacccc accaccacca gctattgcat acctactgaa atcattggac agtgaagcag     6000

ttagggagta ctgtaaagag aatggatggc tcgttcctga aattagctct acccttcata     6060

ttgaaaaaca tgtaagccga gcctttatct gtctccaggc actgacaact tttgtatccg     6120

tggccggtat tatctacatc atttataaac tatttgcagg gtttcaaggc gcctacacag     6180

ggatgcccaa ccaaaagcca aaaataccca cactaaggca agccaaggtg cagggacctg     6240

cttgtgagtt tgctgtagcc atgatgaaga gaaactccat cacagtgaag acagagtatg     6300

gtgagtttac aatgttgggc atctacgaca ggtgggccgt actaccacgc catgcaaaac     6360

ccgggccaac catccttatg aatgaccagg aagttggcgt actagatgca aaagaactag     6420

tggataaaga tggcacaaac cttgaactga cgctgttgaa gcttgaccgg aatgaaaagt     6480

tcagagacat cagaggtttc ctggccaagg aagaagtgga ggtcaatgaa gctgttctag     6540

caataaacac cagcaagttc ccgaacatgt acataccagt tgggcaagta acagactacg     6600

gtttcctgaa cctggggggc actccgacga aaagaatgct catgtacaat tttcctacca     6660

gagctggcca atgtggtggt attcttatgt ctactggtaa ggtgttgggg atacacgttg     6720

gtggaaatgg ccaccagggc ttctcagcag ctctccttaa acactacttc aatgatgaac     6780

aaggtgagat tgaatttatt gaaagctcaa aggaagcagg tttcccagtc attaatactc     6840

caagcaagac taaattggaa ccaagtgtct tccaccaagt gtttgaaggc aacaaggaac     6900

ctgcagttct caggaatggt gatccacgac tcaaagcaaa ttttgaggag gcaatctttt     6960

ccaaatatat tggtaatgtg aacacacacg tagatgagta catgatggaa gccgtggatc     7020

actacgcagg acaattggcc acactggaca ttaatacgga acctatgaaa ttggaggatg     7080

cagtgtatgg cacagagggg ttggaggcac ttgatctaac caccagtgca gggtacccgt     7140

atgtagcact gggcatcaag aagagagaca tcttgtctaa gaagaccaga gatctgacta     7200

aattaaagga gtgtatggac aaatatggtc taaaccttcc gatggtgacc tatgtgaagg     7260

atgagctcag atcagcagaa aaagtggcta aaggcaagtc tagacttatt gaggcatcca     7320

gcctgaacga ctctgtagcg atgagacaaa cttttggcaa tctgtacaga acatttcatt     7380

tgaacccagg gattgtaact ggcagtgcag ttgggtgtga tcctgacctt ttctggagca     7440

aaatacctgt aatgctagat ggacatctca tagcctttga ttactctgga tatgatgcca     7500

gtttgagccc cgtgtggttt gcttgtttga agctattgct agaaaaacta ggatactcac     7560

acaaagaaac aaattacatt gactatttgt gcaattccca ccatttgtac agagacaagc     7620

attacttcgt gcgtggcggc atgccatcag gttgctccgg taccagcatc ttcaactcaa     7680

tgatcaacaa catcataatc aggacgctaa tgttgaaggt gtacaaagga attgacctgg     7740

atcgattcag aatgattgcc tatggcgatg atgttattgc gtcttacccc tggccaatcg     7800

atgcctcttt acttgctgaa gccggcaagg ggtatgggct gatcatgaca ccagcagata     7860

aaggggagtg ttttaatgaa gtcacctgga ctaatgtcac ctttttgaag agatatttca     7920

gagcagatga gcaatacccc tttgtggtcc atcctgttat cccaatgaaa gacatccatg     7980

aatcaattag atggacaaaa gacccaaaga acacccaaga ccatgtgcgc tctttgtgct     8040

tgttggcctg gcacaatggg gagcacgaat atgaggaatt catcaagaag atcagaagcg     8100

tcccagtcgg gcgctgtcta acccttcctg cgttttggac cctgcgcagg aaatggttgg     8160

attcctttta gattagagac aattttctgc aatttgaatt ggcttaaccc taccacactc     8220

accgaactag acaacggtgt ggtaggggta aattctccgc attcggtgcg g              8271


<210>  12
<211>  7428
<212>  RNA
<213>  ˹

<220>
<223>  ECHO25-WTĻ

<400>  12
uuaaaacagc cuguggguug uucccaccca uagggcccac ugggcgcuag cacacuggua       60

uugugguacc uuugugcgcc uguuuuaucu accccucccc caaacgugac uuagaagcuc      120

aacacaugug gucagcaggu ggcccaguau accaacuggg ucuugaucaa gcacuucugu      180

uaccccggac cgaguaucaa uaggcugcuc acgcggcuga aggagaaagu guucguuauc      240

cggccaauua cuacgagaaa ccuaguacca ccauggaagu ugcgcggcgu uucgcuccgc      300

acaaccccag uguagaucag gccgaugagu caccgcacuc cucacgggcg accguggcgg      360

uggcugcgcu ggcggccugc ccauggggca acccauggga cgcuucaaua ccgacauggu      420

gugaagaguc uauugugcua auugguaauc cuccggcccc ugaaugcggc uaaucccaac      480

ugcggagcag auacccacau gccagugggc agucugucgu aacggguaac ucugcagcgg      540

aaccgacuac uuuggguguc cguguuucuu uuuauucuuu auuggcugcu uauggugaca      600

auugagagau uguugccaua uagcuauugg auuggccauc cggugacaaa cagaacaaua      660

guuuaucuau uuguugguuu cauaccauua aauuuuaaag uauuaaagac uaucaacuug      720

aucauacuac uuaauacagc aaaaugggag cucauguguc aacgcagaaa accggagcgc      780

augagacugg uuugagcgcc agugggaauu cgguuauuca uuacacaaca ucaauuauua      840

caaggaugca ucuucaaauu cagcaaacag gcaagacuuu ucacaagacc ccagcaaauu      900

uaccgaaccc uaugaaggau gucaugauua aaucacuccc ggcguuaaau ucacccacug      960

uggaggaaug uggcuacagu gaccgggugc gcuccauuac uuuggguaau ucaacaauca     1020

cuacgcagga aagugcaaau gugguaguug gcuauggugu cuggccggag uauuugaggg     1080

augaggaagc cacggcacaa gaccaaccca cucaaccaga uguugccacc uguagauucu     1140

acacccuaga aucuguuaug ugggagaagu ccucggcggg cugguggugg aaguuuccag     1200

augcucuugc agagaugggc cuauucgguc aaaauaugcu auaccauuau uugggaaggu     1260

caggcuacac aauacacgug caaugcaaug cgucaaaauu ccaccaaggg ugccuucuug     1320

uagucugugu gccagaagcc gagauggguu cugcacagcu ugauaggaca uugaaucaua     1380

ccaaacuuag caacacagaa cacgccagca cauucggguc caugaguucc aaugaagcug     1440

gggccgucca aaauguagug cacaaugccg ggaugggcgu uggagugggu aacuugacca     1500

ucuacccuca ucaguggauu aaucuuagaa ccaacaauug ugccaccaua guaaugccgu     1560

acauaaacag ugugccaaug gauaauaugu uuaggcauua caauuucacc cuuaugguga     1620

uuccauucgc acagcuugau uaugcaccca gcgcguccac ucacguucca auaaccguga     1680

caguugcccc caugugugcc gaauacaacg ggcuaagauu ggcagguaaa cagggcuuac     1740

caacaaugcu cacuccaggu agcaaccagu uccucacguc ugaugauuuc caguccccau     1800

cagcaaugcc acaguuugau guaacgccgg agauugaaau ccccggugac gugaagaauu     1860

uaauggaaau ggcugaaguu gauucugugg ucccagugaa uaaucuggau gauaagguaa     1920

auucaauuga agcuuauaca auccccguca aaucaaugag ugguauugcg acacaagucg     1980

uuggguucca auuacaaccc ggggacgaua gugcguuuaa gaggacacug uuaggagaga     2040

uuuugaacua cuuugcaaau uggucgggaa uuaucaaacu gacauuccca uacugcggug     2100

cggcgaugac cacuggcaca uuccugaucg ccuacucccc uccuggugcu ggcuucccug     2160

cuaaccgcaa ggacucaaug uugggcacuc acauugucug ggacauagga uugcaaucga     2220

guugugugcu cugcgugcca uggaucaguc agacaaacua ccgcuucgug acgcaugacg     2280

cuuauacaga cgcuggguuu auuacaugcu gguaccaaac aaacauagug ucacccccag     2340

acaucccggc agacaguaca auccuauguu uuguuucagc uuguaaugau uucucggugc     2400

gcuuguuaag ggacacgcca uucauaucac aaaacgcacu ucuccaaaau gacccggcua     2460

cugccauugu uagaucagug gaacgggugg ccgauaccau agcaaguggc ccaaugaauu     2520

ccgagagagu cccagcauug acugccgucg agacggguca cacaucucaa guuguuccca     2580

gugauacuau gcaaaccagg cauguuguua accaucacau uagaucggaa ucuucaauag     2640

agaauuuucu gaguagaucg gcaugcguuu acauugaugu guauggcaca aaagagaaug     2700

gugacaucga acguuucacu aacuggaaga ucaacacacg ccagguuguu cagcugaggc     2760

gcaagcugga gauguucacu uacaucagau uugaugugga aauaacauuc guaauuacaa     2820

guacucaagg gacaucaacc caaacaagca cuggcacccc agugcucaca caucaaguga     2880

uguaugugcc acccggaggc cccauacccg cgucauauga ggauuauagc uggcaaacuu     2940

cgacaaaccc cagcguuuuc uggacagaag ggaaugcacc ggcucgcaug ucaauacccu     3000

uuaugagugu gggcaaugcc uauugcaacu uuuaugaugg cuggucacau uucucgcaau     3060

ccggcgugua ugguuucacu acccugaaca acaugggaca gcuguuuuuc agacauguga     3120

auaaggacac acuuggcccu uacaacagca cagugcgugu cuauuucaaa ccaaagcaca     3180

ucaaagcaug ggugcccaga ccaccgcguc uaugcgauua uguguaugca cauaaugucg     3240

auuucacccc cagaggaguc acggacauaa gggaaaagau cacacuggaa agagacgacc     3300

acacgccuuc gaugguaaac cacggugcuu uuggacagca gucuggcgcc auuuacgugg     3360

guaacuacag agugguaaau aggcaccugg ccaccuaugc cgauuggcag aauugcgugu     3420

gggaagauua uaauagagac cucuuaguga gcacaaccac agcgcacggg ugugacacca     3480

ucgcuaggug ucaaugcugc acgggugucu acuuuugugc cucaaggaac aagcacuacc     3540

caguuagcuu ugaagggcca ggccuagugg aaguucagga gagugaguau uacccaaaga     3600

gauaccaguc ccacgugcug uuagccgcag gguuuucuga accaggagac ugugguggaa     3660

uucucaggug cgagcauggu guuaucggac uaguuaccau ggguggcgaa ggcguagucg     3720

gcuuugcuga ugugcgcgac cugcuguggu uggaggauga ugcaauggaa caagggguca     3780

aggguuaugu agaacaauug ggcaaugccu ucgguuccgg guucaccaau caaaucugcg     3840

aacaagucaa ccuccucaaa gaaucacuag ugggccaaga uuccauacua gagaaguccc     3900

uuaaagcucu ugugaaaauc auuucagcac ugguaauagu agugaggaac caugaugacu     3960

uaauuacugu gacugccacc cucgcucuaa uuggcugcac cucaucgccg uggcgguggc     4020

uuaaacagaa ggugucacag uauuacggga uacccauggc ugagcgacaa aacaacgggu     4080

ggcucaaaaa guuuacagag augaccaaug ccugcaaagg gauggagugg auugccguca     4140

agauccaaaa guuuauagaa uggcucaaga uuaaaaucuu accagaggua aaggagaagc     4200

augaguuccu aaccagacuu aaacaacucc cccuucugga aagccaaauu gccaccauug     4260

aacaaagugc accgucccag agugaucagg aacaacucuu cucaaauguu caauacuucg     4320

cccacuacug cagaaaguac gcaccucugu augcuacuga ggccaaaaga guguucuccc     4380

uugagaagaa aaugaguaac uacauacagu ucaaguccaa augccguauu gaaccaguau     4440

guuugcuauu gcacgggagu ccuggagcug ggaaaucggu ugccaccaac uuaauugggc     4500

gaucucuagc ugagaaguug aacaguucag uguauucucu accaccagac ccugaccacu     4560

ucgauggcua uaaacaacaa gccguuguga uuauggacga ccuaugccaa aauccagaug     4620

ggaaggaugu gucauuauuu ugucagaugg ugucgagugu ugacuuuguc ccaccaaugg     4680

cugccuugga agaaaaagga auuuuguuua ccucucccuu ugucuuggcc ucaacuaaug     4740

cugguuccau caaugccccg acggugucag acagcagggc uuuggcuaga agauuccacu     4800

uugacaugaa caucgagguu auaucaaugu acagccagaa uggcaagauu aacaugccca     4860

ugucagucaa aacaugcgac gaagagugcu guccaguuaa cuucaaaaag uguugccccc     4920

uugugugugg aaaagccaua caguuuauag auagaagaac ucaagugagg uacuccuugg     4980

acauguuggu cacugagaug uuuagggagu acaaccauag gcacagcguc ggggcaaccc     5040

uugaggcacu auuucaaggu ccaccaguau acagggagau caaaauuacu guugcaccug     5100

auaccccacc accaccagcu auugcauacc uacugaaauc auuggacagu gaagcaguua     5160

gggaguacug uaaagagaau ggauggcucg uuccugaaau uagcucuacc cuucauauug     5220

aaaaacaugu aagccgagcc uuuaucuguc uccaggcacu gacaacuuuu guauccgugg     5280

ccgguauuau cuacaucauu uauaaacuau uugcaggguu ucaaggcgcc uacacaggga     5340

ugcccaacca aaagccaaaa auacccacac uaaggcaagc caaggugcag ggaccugcuu     5400

gugaguuugc uguagccaug augaagagaa acuccaucac agugaagaca gaguauggug     5460

aguuuacaau guugggcauc uacgacaggu gggccguacu accacgccau gcaaaacccg     5520

ggccaaccau ccuuaugaau gaccaggaag uuggcguacu agaugcaaaa gaacuagugg     5580

auaaagaugg cacaaaccuu gaacugacgc uguugaagcu ugaccggaau gaaaaguuca     5640

gagacaucag agguuuccug gccaaggaag aaguggaggu caaugaagcu guucuagcaa     5700

uaaacaccag caaguucccg aacauguaca uaccaguugg gcaaguaaca gacuacgguu     5760

uccugaaccu ggggggcacu ccgacgaaaa gaaugcucau guacaauuuu ccuaccagag     5820

cuggccaaug uggugguauu cuuaugucua cugguaaggu guuggggaua cacguuggug     5880

gaaauggcca ccagggcuuc ucagcagcuc uccuuaaaca cuacuucaau gaugaacaag     5940

gugagauuga auuuauugaa agcucaaagg aagcagguuu cccagucauu aauacuccaa     6000

gcaagacuaa auuggaacca agugucuucc accaaguguu ugaaggcaac aaggaaccug     6060

caguucucag gaauggugau ccacgacuca aagcaaauuu ugaggaggca aucuuuucca     6120

aauauauugg uaaugugaac acacacguag augaguacau gauggaagcc guggaucacu     6180

acgcaggaca auuggccaca cuggacauua auacggaacc uaugaaauug gaggaugcag     6240

uguauggcac agagggguug gaggcacuug aucuaaccac cagugcaggg uacccguaug     6300

uagcacuggg caucaagaag agagacaucu ugucuaagaa gaccagagau cugacuaaau     6360

uaaaggagug uauggacaaa uauggucuaa accuuccgau ggugaccuau gugaaggaug     6420

agcucagauc agcagaaaaa guggcuaaag gcaagucuag acuuauugag gcauccagcc     6480

ugaacgacuc uguagcgaug agacaaacuu uuggcaaucu guacagaaca uuucauuuga     6540

acccagggau uguaacuggc agugcaguug ggugugaucc ugaccuuuuc uggagcaaaa     6600

uaccuguaau gcuagaugga caucucauag ccuuugauua cucuggauau gaugccaguu     6660

ugagccccgu gugguuugcu uguuugaagc uauugcuaga aaaacuagga uacucacaca     6720

aagaaacaaa uuacauugac uauuugugca auucccacca uuuguacaga gacaagcauu     6780

acuucgugcg uggcggcaug ccaucagguu gcuccgguac cagcaucuuc aacucaauga     6840

ucaacaacau cauaaucagg acgcuaaugu ugaaggugua caaaggaauu gaccuggauc     6900

gauucagaau gauugccuau ggcgaugaug uuauugcguc uuaccccugg ccaaucgaug     6960

ccucuuuacu ugcugaagcc ggcaaggggu augggcugau caugacacca gcagauaaag     7020

gggaguguuu uaaugaaguc accuggacua augucaccuu uuugaagaga uauuucagag     7080

cagaugagca auaccccuuu gugguccauc cuguuauccc aaugaaagac auccaugaau     7140

caauuagaug gacaaaagac ccaaagaaca cccaagacca ugugcgcucu uugugcuugu     7200

uggccuggca caauggggag cacgaauaug aggaauucau caagaagauc agaagcgucc     7260

cagucgggcg cugucuaacc cuuccugcgu uuuggacccu gcgcaggaaa ugguuggauu     7320

ccuuuuagau uagagacaau uuucugcaau uugaauuggc uuaacccuac cacacucacc     7380

gaacuagaca acgguguggu agggguaaau ucuccgcauu cggugcgg                  7428


<210>  13
<211>  7309
<212>  RNA
<213>  ˹

<220>
<223>  ECHO25-HRV2Ļ

<400>  13
uuaaaacagc cuguggguug uucccaccca uagggcccac ugggcgcuag cacacuggua       60

uugugguacc uuugugcgcc uguuuuaucu accccucccc caaacgugac uuagaagaac      120

uuagaaguuu uucacaaaga ccaauagccg guaaucagcc agauuacuga aggucaagca      180

cuucuguuuc cccggucaau guugauaugc uccaacaggg caaaaacaac ugcgaucguu      240

aaccgcaaag cgccuacgca aagcuuagua gcaucuuuga aaucguuugg cuggucgauc      300

cgccauuucc ccugguagac cuggcagaug aggcuagaaa uaccccacug gcgacagugu      360

ucuagccugc guggcugccu gcacacccua ugggugugaa gccaaacaau ggacaaggug      420

ugaagagccc cgugugcucg cuuugagucc uccggccccu gaauguggcu aaccuuaacc      480

cugcagcuag agcacguaac ccaaugugua ucuagucgua augagcaauu gcgggauggg      540

accaacuacu uugggugucc guguuucacu uuuuccuuua uauuugcuua uggugacaau      600

auauacaaua uauauauugg caccauggga gcucaugugu caacgcagaa aaccggagcg      660

caugagacug guuugagcgc cagugggaau ucgguuauuc auuacacaac aucaauuauu      720

acaaggaugc aucuucaaau ucagcaaaca ggcaagacuu uucacaagac cccagcaaau      780

uuaccgaacc cuaugaagga ugucaugauu aaaucacucc cggcguuaaa uucacccacu      840

guggaggaau guggcuacag ugaccgggug cgcuccauua cuuuggguaa uucaacaauc      900

acuacgcagg aaagugcaaa ugugguaguu ggcuauggug ucuggccgga guauuugagg      960

gaugaggaag ccacggcaca agaccaaccc acucaaccag auguugccac cuguagauuc     1020

uacacccuag aaucuguuau gugggagaag uccucggcgg gcugguggug gaaguuucca     1080

gaugcucuug cagagauggg ccuauucggu caaaauaugc uauaccauua uuugggaagg     1140

ucaggcuaca caauacacgu gcaaugcaau gcgucaaaau uccaccaagg gugccuucuu     1200

guagucugug ugccagaagc cgagaugggu ucugcacagc uugauaggac auugaaucau     1260

accaaacuua gcaacacaga acacgccagc acauucgggu ccaugaguuc caaugaagcu     1320

ggggccgucc aaaauguagu gcacaaugcc gggaugggcg uuggaguggg uaacuugacc     1380

aucuacccuc aucaguggau uaaucuuaga accaacaauu gugccaccau aguaaugccg     1440

uacauaaaca gugugccaau ggauaauaug uuuaggcauu acaauuucac ccuuauggug     1500

auuccauucg cacagcuuga uuaugcaccc agcgcgucca cucacguucc aauaaccgug     1560

acaguugccc ccaugugugc cgaauacaac gggcuaagau uggcagguaa acagggcuua     1620

ccaacaaugc ucacuccagg uagcaaccag uuccucacgu cugaugauuu ccagucccca     1680

ucagcaaugc cacaguuuga uguaacgccg gagauugaaa uccccgguga cgugaagaau     1740

uuaauggaaa uggcugaagu ugauucugug gucccaguga auaaucugga ugauaaggua     1800

aauucaauug aagcuuauac aauccccguc aaaucaauga gugguauugc gacacaaguc     1860

guuggguucc aauuacaacc cggggacgau agugcguuua agaggacacu guuaggagag     1920

auuuugaacu acuuugcaaa uuggucggga auuaucaaac ugacauuccc auacugcggu     1980

gcggcgauga ccacuggcac auuccugauc gccuacuccc cuccuggugc uggcuucccu     2040

gcuaaccgca aggacucaau guugggcacu cacauugucu gggacauagg auugcaaucg     2100

aguugugugc ucugcgugcc auggaucagu cagacaaacu accgcuucgu gacgcaugac     2160

gcuuauacag acgcuggguu uauuacaugc ugguaccaaa caaacauagu gucaccccca     2220

gacaucccgg cagacaguac aauccuaugu uuuguuucag cuuguaauga uuucucggug     2280

cgcuuguuaa gggacacgcc auucauauca caaaacgcac uucuccaaaa ugacccggcu     2340

acugccauug uuagaucagu ggaacgggug gccgauacca uagcaagugg cccaaugaau     2400

uccgagagag ucccagcauu gacugccguc gagacggguc acacaucuca aguuguuccc     2460

agugauacua ugcaaaccag gcauguuguu aaccaucaca uuagaucgga aucuucaaua     2520

gagaauuuuc ugaguagauc ggcaugcguu uacauugaug uguauggcac aaaagagaau     2580

ggugacaucg aacguuucac uaacuggaag aucaacacac gccagguugu ucagcugagg     2640

cgcaagcugg agauguucac uuacaucaga uuugaugugg aaauaacauu cguaauuaca     2700

aguacucaag ggacaucaac ccaaacaagc acuggcaccc cagugcucac acaucaagug     2760

auguaugugc cacccggagg ccccauaccc gcgucauaug aggauuauag cuggcaaacu     2820

ucgacaaacc ccagcguuuu cuggacagaa gggaaugcac cggcucgcau gucaauaccc     2880

uuuaugagug ugggcaaugc cuauugcaac uuuuaugaug gcuggucaca uuucucgcaa     2940

uccggcgugu augguuucac uacccugaac aacaugggac agcuguuuuu cagacaugug     3000

aauaaggaca cacuuggccc uuacaacagc acagugcgug ucuauuucaa accaaagcac     3060

aucaaagcau gggugcccag accaccgcgu cuaugcgauu auguguaugc acauaauguc     3120

gauuucaccc ccagaggagu cacggacaua agggaaaaga ucacacugga aagagacgac     3180

cacacgccuu cgaugguaaa ccacggugcu uuuggacagc agucuggcgc cauuuacgug     3240

gguaacuaca gagugguaaa uaggcaccug gccaccuaug ccgauuggca gaauugcgug     3300

ugggaagauu auaauagaga ccucuuagug agcacaacca cagcgcacgg gugugacacc     3360

aucgcuaggu gucaaugcug cacggguguc uacuuuugug ccucaaggaa caagcacuac     3420

ccaguuagcu uugaagggcc aggccuagug gaaguucagg agagugagua uuacccaaag     3480

agauaccagu cccacgugcu guuagccgca ggguuuucug aaccaggaga cuguggugga     3540

auucucaggu gcgagcaugg uguuaucgga cuaguuacca uggguggcga aggcguaguc     3600

ggcuuugcug augugcgcga ccugcugugg uuggaggaug augcaaugga acaagggguc     3660

aaggguuaug uagaacaauu gggcaaugcc uucgguuccg gguucaccaa ucaaaucugc     3720

gaacaaguca accuccucaa agaaucacua gugggccaag auuccauacu agagaagucc     3780

cuuaaagcuc uugugaaaau cauuucagca cugguaauag uagugaggaa ccaugaugac     3840

uuaauuacug ugacugccac ccucgcucua auuggcugca ccucaucgcc guggcggugg     3900

cuuaaacaga aggugucaca guauuacggg auacccaugg cugagcgaca aaacaacggg     3960

uggcucaaaa aguuuacaga gaugaccaau gccugcaaag ggauggagug gauugccguc     4020

aagauccaaa aguuuauaga auggcucaag auuaaaaucu uaccagaggu aaaggagaag     4080

caugaguucc uaaccagacu uaaacaacuc ccccuucugg aaagccaaau ugccaccauu     4140

gaacaaagug caccguccca gagugaucag gaacaacucu ucucaaaugu ucaauacuuc     4200

gcccacuacu gcagaaagua cgcaccucug uaugcuacug aggccaaaag aguguucucc     4260

cuugagaaga aaaugaguaa cuacauacag uucaagucca aaugccguau ugaaccagua     4320

uguuugcuau ugcacgggag uccuggagcu gggaaaucgg uugccaccaa cuuaauuggg     4380

cgaucucuag cugagaaguu gaacaguuca guguauucuc uaccaccaga cccugaccac     4440

uucgauggcu auaaacaaca agccguugug auuauggacg accuaugcca aaauccagau     4500

gggaaggaug ugucauuauu uugucagaug gugucgagug uugacuuugu cccaccaaug     4560

gcugccuugg aagaaaaagg aauuuuguuu accucucccu uugucuuggc cucaacuaau     4620

gcugguucca ucaaugcccc gacgguguca gacagcaggg cuuuggcuag aagauuccac     4680

uuugacauga acaucgaggu uauaucaaug uacagccaga auggcaagau uaacaugccc     4740

augucaguca aaacaugcga cgaagagugc uguccaguua acuucaaaaa guguugcccc     4800

cuugugugug gaaaagccau acaguuuaua gauagaagaa cucaagugag guacuccuug     4860

gacauguugg ucacugagau guuuagggag uacaaccaua ggcacagcgu cggggcaacc     4920

cuugaggcac uauuucaagg uccaccagua uacagggaga ucaaaauuac uguugcaccu     4980

gauaccccac caccaccagc uauugcauac cuacugaaau cauuggacag ugaagcaguu     5040

agggaguacu guaaagagaa uggauggcuc guuccugaaa uuagcucuac ccuucauauu     5100

gaaaaacaug uaagccgagc cuuuaucugu cuccaggcac ugacaacuuu uguauccgug     5160

gccgguauua ucuacaucau uuauaaacua uuugcagggu uucaaggcgc cuacacaggg     5220

augcccaacc aaaagccaaa aauacccaca cuaaggcaag ccaaggugca gggaccugcu     5280

ugugaguuug cuguagccau gaugaagaga aacuccauca cagugaagac agaguauggu     5340

gaguuuacaa uguugggcau cuacgacagg ugggccguac uaccacgcca ugcaaaaccc     5400

gggccaacca uccuuaugaa ugaccaggaa guuggcguac uagaugcaaa agaacuagug     5460

gauaaagaug gcacaaaccu ugaacugacg cuguugaagc uugaccggaa ugaaaaguuc     5520

agagacauca gagguuuccu ggccaaggaa gaaguggagg ucaaugaagc uguucuagca     5580

auaaacacca gcaaguuccc gaacauguac auaccaguug ggcaaguaac agacuacggu     5640

uuccugaacc uggggggcac uccgacgaaa agaaugcuca uguacaauuu uccuaccaga     5700

gcuggccaau guggugguau ucuuaugucu acugguaagg uguuggggau acacguuggu     5760

ggaaauggcc accagggcuu cucagcagcu cuccuuaaac acuacuucaa ugaugaacaa     5820

ggugagauug aauuuauuga aagcucaaag gaagcagguu ucccagucau uaauacucca     5880

agcaagacua aauuggaacc aagugucuuc caccaagugu uugaaggcaa caaggaaccu     5940

gcaguucuca ggaaugguga uccacgacuc aaagcaaauu uugaggaggc aaucuuuucc     6000

aaauauauug guaaugugaa cacacacgua gaugaguaca ugauggaagc cguggaucac     6060

uacgcaggac aauuggccac acuggacauu aauacggaac cuaugaaauu ggaggaugca     6120

guguauggca cagagggguu ggaggcacuu gaucuaacca ccagugcagg guacccguau     6180

guagcacugg gcaucaagaa gagagacauc uugucuaaga agaccagaga ucugacuaaa     6240

uuaaaggagu guauggacaa auauggucua aaccuuccga uggugaccua ugugaaggau     6300

gagcucagau cagcagaaaa aguggcuaaa ggcaagucua gacuuauuga ggcauccagc     6360

cugaacgacu cuguagcgau gagacaaacu uuuggcaauc uguacagaac auuucauuug     6420

aacccaggga uuguaacugg cagugcaguu gggugugauc cugaccuuuu cuggagcaaa     6480

auaccuguaa ugcuagaugg acaucucaua gccuuugauu acucuggaua ugaugccagu     6540

uugagccccg ugugguuugc uuguuugaag cuauugcuag aaaaacuagg auacucacac     6600

aaagaaacaa auuacauuga cuauuugugc aauucccacc auuuguacag agacaagcau     6660

uacuucgugc guggcggcau gccaucaggu ugcuccggua ccagcaucuu caacucaaug     6720

aucaacaaca ucauaaucag gacgcuaaug uugaaggugu acaaaggaau ugaccuggau     6780

cgauucagaa ugauugccua uggcgaugau guuauugcgu cuuaccccug gccaaucgau     6840

gccucuuuac uugcugaagc cggcaagggg uaugggcuga ucaugacacc agcagauaaa     6900

ggggaguguu uuaaugaagu caccuggacu aaugucaccu uuuugaagag auauuucaga     6960

gcagaugagc aauaccccuu ugugguccau ccuguuaucc caaugaaaga cauccaugaa     7020

ucaauuagau ggacaaaaga cccaaagaac acccaagacc augugcgcuc uuugugcuug     7080

uuggccuggc acaaugggga gcacgaauau gaggaauuca ucaagaagau cagaagcguc     7140

ccagucgggc gcugucuaac ccuuccugcg uuuuggaccc ugcgcaggaa augguuggau     7200

uccuuuuaga uuagagacaa uuuucugcaa uuugaauugg cuuaacccua ccacacucac     7260

cgaacuagac aacggugugg uagggguaaa uucuccgcau ucggugcgg                 7309


<210>  14
<211>  7530
<212>  RNA
<213>  ˹

<220>
<223>  ECHO25-miR133&206TĻ

<400>  14
uuaaaacagc cuguggguug uucccaccca uagggcccac ugggcgcuag cacacuggua       60

uugugguacc uuugugcgcc uguuuuaucu accccucccc caaacgugac uuagaagcuc      120

aacacaugug gucagcaggu ggcccaguau accaacuggg ucuugaucaa gcacuucugu      180

uaccccggac cgaguaucaa uaggcugcuc acgcggcuga aggagaaagu guucguuauc      240

cggccaauua cuacgagaaa ccuaguacca ccauggaagu ugcgcggcgu uucgcuccgc      300

acaaccccag uguagaucag gccgaugagu caccgcacuc cucacgggcg accguggcgg      360

uggcugcgcu ggcggccugc ccauggggca acccauggga cgcuucaaua ccgacauggu      420

gugaagaguc uauugugcua auugguaauc cuccggcccc ugaaugcggc uaaucccaac      480

ugcggagcag auacccacau gccagugggc agucugucgu aacggguaac ucugcagcgg      540

aaccgacuac uuuggguguc cguguuucuu uuuauucuuu auuggcugcu uauggugaca      600

auugagagau uguugccaua uagcuauugg auuggccauc cggugacaaa cagaacaaua      660

guuuaucuau uuguugguuu cauaccauua aauuuuaaag uauuaaagac uaucaacuug      720

aucauacuac uuaauacagc aaaaugggag cucauguguc aacgcagaaa accggagcgc      780

augagacugg uuugagcgcc agugggaauu cgguuauuca uuacacaaca ucaauuauua      840

caaggaugca ucuucaaauu cagcaaacag gcaagacuuu ucacaagacc ccagcaaauu      900

uaccgaaccc uaugaaggau gucaugauua aaucacuccc ggcguuaaau ucacccacug      960

uggaggaaug uggcuacagu gaccgggugc gcuccauuac uuuggguaau ucaacaauca     1020

cuacgcagga aagugcaaau gugguaguug gcuauggugu cuggccggag uauuugaggg     1080

augaggaagc cacggcacaa gaccaaccca cucaaccaga uguugccacc uguagauucu     1140

acacccuaga aucuguuaug ugggagaagu ccucggcggg cugguggugg aaguuuccag     1200

augcucuugc agagaugggc cuauucgguc aaaauaugcu auaccauuau uugggaaggu     1260

caggcuacac aauacacgug caaugcaaug cgucaaaauu ccaccaaggg ugccuucuug     1320

uagucugugu gccagaagcc gagauggguu cugcacagcu ugauaggaca uugaaucaua     1380

ccaaacuuag caacacagaa cacgccagca cauucggguc caugaguucc aaugaagcug     1440

gggccgucca aaauguagug cacaaugccg ggaugggcgu uggagugggu aacuugacca     1500

ucuacccuca ucaguggauu aaucuuagaa ccaacaauug ugccaccaua guaaugccgu     1560

acauaaacag ugugccaaug gauaauaugu uuaggcauua caauuucacc cuuaugguga     1620

uuccauucgc acagcuugau uaugcaccca gcgcguccac ucacguucca auaaccguga     1680

caguugcccc caugugugcc gaauacaacg ggcuaagauu ggcagguaaa cagggcuuac     1740

caacaaugcu cacuccaggu agcaaccagu uccucacguc ugaugauuuc caguccccau     1800

cagcaaugcc acaguuugau guaacgccgg agauugaaau ccccggugac gugaagaauu     1860

uaauggaaau ggcugaaguu gauucugugg ucccagugaa uaaucuggau gauaagguaa     1920

auucaauuga agcuuauaca auccccguca aaucaaugag ugguauugcg acacaagucg     1980

uuggguucca auuacaaccc ggggacgaua gugcguuuaa gaggacacug uuaggagaga     2040

uuuugaacua cuuugcaaau uggucgggaa uuaucaaacu gacauuccca uacugcggug     2100

cggcgaugac cacuggcaca uuccugaucg ccuacucccc uccuggugcu ggcuucccug     2160

cuaaccgcaa ggacucaaug uugggcacuc acauugucug ggacauagga uugcaaucga     2220

guugugugcu cugcgugcca uggaucaguc agacaaacua ccgcuucgug acgcaugacg     2280

cuuauacaga cgcuggguuu auuacaugcu gguaccaaac aaacauagug ucacccccag     2340

acaucccggc agacaguaca auccuauguu uuguuucagc uuguaaugau uucucggugc     2400

gcuuguuaag ggacacgcca uucauaucac aaaacgcacu ucuccaaaau gacccggcua     2460

cugccauugu uagaucagug gaacgggugg ccgauaccau agcaaguggc ccaaugaauu     2520

ccgagagagu cccagcauug acugccgucg agacggguca cacaucucaa guuguuccca     2580

gugauacuau gcaaaccagg cauguuguua accaucacau uagaucggaa ucuucaauag     2640

agaauuuucu gaguagaucg gcaugcguuu acauugaugu guauggcaca aaagagaaug     2700

gugacaucga acguuucacu aacuggaaga ucaacacacg ccagguuguu cagcugaggc     2760

gcaagcugga gauguucacu uacaucagau uugaugugga aauaacauuc guaauuacaa     2820

guacucaagg gacaucaacc caaacaagca cuggcacccc agugcucaca caucaaguga     2880

uguaugugcc acccggaggc cccauacccg cgucauauga ggauuauagc uggcaaacuu     2940

cgacaaaccc cagcguuuuc uggacagaag ggaaugcacc ggcucgcaug ucaauacccu     3000

uuaugagugu gggcaaugcc uauugcaacu uuuaugaugg cuggucacau uucucgcaau     3060

ccggcgugua ugguuucacu acccugaaca acaugggaca gcuguuuuuc agacauguga     3120

auaaggacac acuuggcccu uacaacagca cagugcgugu cuauuucaaa ccaaagcaca     3180

ucaaagcaug ggugcccaga ccaccgcguc uaugcgauua uguguaugca cauaaugucg     3240

auuucacccc cagaggaguc acggacauaa gggaaaagau cacacuggaa agagacgacc     3300

acacgccuuc gaugguaaac cacggugcuu uuggacagca gucuggcgcc auuuacgugg     3360

guaacuacag agugguaaau aggcaccugg ccaccuaugc cgauuggcag aauugcgugu     3420

gggaagauua uaauagagac cucuuaguga gcacaaccac agcgcacggg ugugacacca     3480

ucgcuaggug ucaaugcugc acgggugucu acuuuugugc cucaaggaac aagcacuacc     3540

caguuagcuu ugaagggcca ggccuagugg aaguucagga gagugaguau uacccaaaga     3600

gauaccaguc ccacgugcug uuagccgcag gguuuucuga accaggagac ugugguggaa     3660

uucucaggug cgagcauggu guuaucggac uaguuaccau ggguggcgaa ggcguagucg     3720

gcuuugcuga ugugcgcgac cugcuguggu uggaggauga ugcaauggaa caagggguca     3780

aggguuaugu agaacaauug ggcaaugccu ucgguuccgg guucaccaau caaaucugcg     3840

aacaagucaa ccuccucaaa gaaucacuag ugggccaaga uuccauacua gagaaguccc     3900

uuaaagcucu ugugaaaauc auuucagcac ugguaauagu agugaggaac caugaugacu     3960

uaauuacugu gacugccacc cucgcucuaa uuggcugcac cucaucgccg uggcgguggc     4020

uuaaacagaa ggugucacag uauuacggga uacccauggc ugagcgacaa aacaacgggu     4080

ggcucaaaaa guuuacagag augaccaaug ccugcaaagg gauggagugg auugccguca     4140

agauccaaaa guuuauagaa uggcucaaga uuaaaaucuu accagaggua aaggagaagc     4200

augaguuccu aaccagacuu aaacaacucc cccuucugga aagccaaauu gccaccauug     4260

aacaaagugc accgucccag agugaucagg aacaacucuu cucaaauguu caauacuucg     4320

cccacuacug cagaaaguac gcaccucugu augcuacuga ggccaaaaga guguucuccc     4380

uugagaagaa aaugaguaac uacauacagu ucaaguccaa augccguauu gaaccaguau     4440

guuugcuauu gcacgggagu ccuggagcug ggaaaucggu ugccaccaac uuaauugggc     4500

gaucucuagc ugagaaguug aacaguucag uguauucucu accaccagac ccugaccacu     4560

ucgauggcua uaaacaacaa gccguuguga uuauggacga ccuaugccaa aauccagaug     4620

ggaaggaugu gucauuauuu ugucagaugg ugucgagugu ugacuuuguc ccaccaaugg     4680

cugccuugga agaaaaagga auuuuguuua ccucucccuu ugucuuggcc ucaacuaaug     4740

cugguuccau caaugccccg acggugucag acagcagggc uuuggcuaga agauuccacu     4800

uugacaugaa caucgagguu auaucaaugu acagccagaa uggcaagauu aacaugccca     4860

ugucagucaa aacaugcgac gaagagugcu guccaguuaa cuucaaaaag uguugccccc     4920

uugugugugg aaaagccaua caguuuauag auagaagaac ucaagugagg uacuccuugg     4980

acauguuggu cacugagaug uuuagggagu acaaccauag gcacagcguc ggggcaaccc     5040

uugaggcacu auuucaaggu ccaccaguau acagggagau caaaauuacu guugcaccug     5100

auaccccacc accaccagcu auugcauacc uacugaaauc auuggacagu gaagcaguua     5160

gggaguacug uaaagagaau ggauggcucg uuccugaaau uagcucuacc cuucauauug     5220

aaaaacaugu aagccgagcc uuuaucuguc uccaggcacu gacaacuuuu guauccgugg     5280

ccgguauuau cuacaucauu uauaaacuau uugcaggguu ucaaggcgcc uacacaggga     5340

ugcccaacca aaagccaaaa auacccacac uaaggcaagc caaggugcag ggaccugcuu     5400

gugaguuugc uguagccaug augaagagaa acuccaucac agugaagaca gaguauggug     5460

aguuuacaau guugggcauc uacgacaggu gggccguacu accacgccau gcaaaacccg     5520

ggccaaccau ccuuaugaau gaccaggaag uuggcguacu agaugcaaaa gaacuagugg     5580

auaaagaugg cacaaaccuu gaacugacgc uguugaagcu ugaccggaau gaaaaguuca     5640

gagacaucag agguuuccug gccaaggaag aaguggaggu caaugaagcu guucuagcaa     5700

uaaacaccag caaguucccg aacauguaca uaccaguugg gcaaguaaca gacuacgguu     5760

uccugaaccu ggggggcacu ccgacgaaaa gaaugcucau guacaauuuu ccuaccagag     5820

cuggccaaug uggugguauu cuuaugucua cugguaaggu guuggggaua cacguuggug     5880

gaaauggcca ccagggcuuc ucagcagcuc uccuuaaaca cuacuucaau gaugaacaag     5940

gugagauuga auuuauugaa agcucaaagg aagcagguuu cccagucauu aauacuccaa     6000

gcaagacuaa auuggaacca agugucuucc accaaguguu ugaaggcaac aaggaaccug     6060

caguucucag gaauggugau ccacgacuca aagcaaauuu ugaggaggca aucuuuucca     6120

aauauauugg uaaugugaac acacacguag augaguacau gauggaagcc guggaucacu     6180

acgcaggaca auuggccaca cuggacauua auacggaacc uaugaaauug gaggaugcag     6240

uguauggcac agagggguug gaggcacuug aucuaaccac cagugcaggg uacccguaug     6300

uagcacuggg caucaagaag agagacaucu ugucuaagaa gaccagagau cugacuaaau     6360

uaaaggagug uauggacaaa uauggucuaa accuuccgau ggugaccuau gugaaggaug     6420

agcucagauc agcagaaaaa guggcuaaag gcaagucuag acuuauugag gcauccagcc     6480

ugaacgacuc uguagcgaug agacaaacuu uuggcaaucu guacagaaca uuucauuuga     6540

acccagggau uguaacuggc agugcaguug ggugugaucc ugaccuuuuc uggagcaaaa     6600

uaccuguaau gcuagaugga caucucauag ccuuugauua cucuggauau gaugccaguu     6660

ugagccccgu gugguuugcu uguuugaagc uauugcuaga aaaacuagga uacucacaca     6720

aagaaacaaa uuacauugac uauuugugca auucccacca uuuguacaga gacaagcauu     6780

acuucgugcg uggcggcaug ccaucagguu gcuccgguac cagcaucuuc aacucaauga     6840

ucaacaacau cauaaucagg acgcuaaugu ugaaggugua caaaggaauu gaccuggauc     6900

gauucagaau gauugccuau ggcgaugaug uuauugcguc uuaccccugg ccaaucgaug     6960

ccucuuuacu ugcugaagcc ggcaaggggu augggcugau caugacacca gcagauaaag     7020

gggaguguuu uaaugaaguc accuggacua augucaccuu uuugaagaga uauuucagag     7080

cagaugagca auaccccuuu gugguccauc cuguuauccc aaugaaagac auccaugaau     7140

caauuagaug gacaaaagac ccaaagaaca cccaagacca ugugcgcucu uugugcuugu     7200

uggccuggca caauggggag cacgaauaug aggaauucau caagaagauc agaagcgucc     7260

cagucgggcg cugucuaacc cuuccugcgu uuuggacccu gcgcaggaaa ugguuggauu     7320

ccuuuuagau uagagacaca gcugguugaa ggggaccaac gauacagcug guugaagggg     7380

accaaaccgg uccacacacu uccuuacauu ccaucaccca cacacuuccu uacauuccaa     7440

auuuucugca auuugaauug gcuuaacccu accacacuca ccgaacuaga caacggugug     7500

guagggguaa auucuccgca uucggugcgg                                      7530


<210>  15
<211>  7905
<212>  RNA
<213>  ˹

<220>
<223>  ECHO25-GM-CSFĻ

<400>  15
uuaaaacagc cuguggguug uucccaccca uagggcccac ugggcgcuag cacacuggua       60

uugugguacc uuugugcgcc uguuuuaucu accccucccc caaacgugac uuagaagcuc      120

aacacaugug gucagcaggu ggcccaguau accaacuggg ucuugaucaa gcacuucugu      180

uaccccggac cgaguaucaa uaggcugcuc acgcggcuga aggagaaagu guucguuauc      240

cggccaauua cuacgagaaa ccuaguacca ccauggaagu ugcgcggcgu uucgcuccgc      300

acaaccccag uguagaucag gccgaugagu caccgcacuc cucacgggcg accguggcgg      360

uggcugcgcu ggcggccugc ccauggggca acccauggga cgcuucaaua ccgacauggu      420

gugaagaguc uauugugcua auugguaauc cuccggcccc ugaaugcggc uaaucccaac      480

ugcggagcag auacccacau gccagugggc agucugucgu aacggguaac ucugcagcgg      540

aaccgacuac uuuggguguc cguguuucuu uuuauucuuu auuggcugcu uauggugaca      600

auugagagau uguugccaua uagcuauugg auuggccauc cggugacaaa cagaacaaua      660

guuuaucuau uuguugguuu cauaccauua aauuuuaaag uauuaaagac uaucaacuug      720

aucauacuac uuaauacagc aaaaugggag cucauguguc aacgcagaaa accggagcgc      780

augagacugg uuugagcgcc agugggaauu cgguuauuca uuacacaaca ucaauuauua      840

caaggaugca ucuucaaauu cagcaaacag gcaagacuuu ucacaagacc ccagcaaauu      900

uaccgaaccc uaugaaggau gucaugauua aaucacuccc ggcguuaaau ucacccacug      960

uggaggaaug uggcuacagu gaccgggugc gcuccauuac uuuggguaau ucaacaauca     1020

cuacgcagga aagugcaaau gugguaguug gcuauggugu cuggccggag uauuugaggg     1080

augaggaagc cacggcacaa gaccaaccca cucaaccaga uguugccacc uguagauucu     1140

acacccuaga aucuguuaug ugggagaagu ccucggcggg cugguggugg aaguuuccag     1200

augcucuugc agagaugggc cuauucgguc aaaauaugcu auaccauuau uugggaaggu     1260

caggcuacac aauacacgug caaugcaaug cgucaaaauu ccaccaaggg ugccuucuug     1320

uagucugugu gccagaagcc gagauggguu cugcacagcu ugauaggaca uugaaucaua     1380

ccaaacuuag caacacagaa cacgccagca cauucggguc caugaguucc aaugaagcug     1440

gggccgucca aaauguagug cacaaugccg ggaugggcgu uggagugggu aacuugacca     1500

ucuacccuca ucaguggauu aaucuuagaa ccaacaauug ugccaccaua guaaugccgu     1560

acauaaacag ugugccaaug gauaauaugu uuaggcauua caauuucacc cuuaugguga     1620

uuccauucgc acagcuugau uaugcaccca gcgcguccac ucacguucca auaaccguga     1680

caguugcccc caugugugcc gaauacaacg ggcuaagauu ggcagguaaa cagggcuuac     1740

caacaaugcu cacuccaggu agcaaccagu uccucacguc ugaugauuuc caguccccau     1800

cagcaaugcc acaguuugau guaacgccgg agauugaaau ccccggugac gugaagaauu     1860

uaauggaaau ggcugaaguu gauucugugg ucccagugaa uaaucuggau gauaagguaa     1920

auucaauuga agcuuauaca auccccguca aaucaaugag ugguauugcg acacaagucg     1980

uuggguucca auuacaaccc ggggacgaua gugcguuuaa gaggacacug uuaggagaga     2040

uuuugaacua cuuugcaaau uggucgggaa uuaucaaacu gacauuccca uacugcggug     2100

cggcgaugac cacuggcaca uuccugaucg ccuacucccc uccuggugcu ggcuucccug     2160

cuaaccgcaa ggacucaaug uugggcacuc acauugucug ggacauagga uugcaaucga     2220

guugugugcu cugcgugcca uggaucaguc agacaaacua ccgcuucgug acgcaugacg     2280

cuuauacaga cgcuggguuu auuacaugcu gguaccaaac aaacauagug ucacccccag     2340

acaucccggc agacaguaca auccuauguu uuguuucagc uuguaaugau uucucggugc     2400

gcuuguuaag ggacacgcca uucauaucac aaaacgcacu ucuccaaaau gacccggcua     2460

cugccauugu uagaucagug gaacgggugg ccgauaccau agcaaguggc ccaaugaauu     2520

ccgagagagu cccagcauug acugccgucg agacggguca cacaucucaa guuguuccca     2580

gugauacuau gcaaaccagg cauguuguua accaucacau uagaucggaa ucuucaauag     2640

agaauuuucu gaguagaucg gcaugcguuu acauugaugu guauggcaca aaagagaaug     2700

gugacaucga acguuucacu aacuggaaga ucaacacacg ccagguuguu cagcugaggc     2760

gcaagcugga gauguucacu uacaucagau uugaugugga aauaacauuc guaauuacaa     2820

guacucaagg gacaucaacc caaacaagca cuggcacccc agugcucaca caucaaguga     2880

uguaugugcc acccggaggc cccauacccg cgucauauga ggauuauagc uggcaaacuu     2940

cgacaaaccc cagcguuuuc uggacagaag ggaaugcacc ggcucgcaug ucaauacccu     3000

uuaugagugu gggcaaugcc uauugcaacu uuuaugaugg cuggucacau uucucgcaau     3060

ccggcgugua ugguuucacu acccugaaca acaugggaca gcuguuuuuc agacauguga     3120

auaaggacac acuuggcccu uacaacagca cagugcgugu cuauuucaaa ccaaagcaca     3180

ucaaagcaug ggugcccaga ccaccgcguc uaugcgauua uguguaugca cauaaugucg     3240

auuucacccc cagaggaguc acggacauaa gggaaaagau cacacuggaa agagacgacc     3300

acacgccuuc gaugguaaac cacggugcuu uuggacagca guggcugcag agccugcugc     3360

ucuugggcac uguggccugc agcaucucug cacccgcccg cucgcccagc cccagcacgc     3420

agcccuggga gcaugugaau gccauccagg aggcccggcg ucuccugaac cugaguagag     3480

acacugcugc ugagaugaau gaaacaguag aagucaucuc agaaauguuu gaccuccagg     3540

agccgaccug ccuacagacc cgccuggagc uguacaagca gggccugcgg ggcagccuca     3600

ccaagcucaa gggccccuug accaugaugg ccagccacua caagcagcac ugcccuccaa     3660

ccccggaaac uuccugugca acccagauua ucaccuuuga aaguuucaaa gagaaccuga     3720

aggacuuucu gcuugucauc cccuuugacu gcugggagcc aguccaggag gacgaccaca     3780

cgccuucgau gguaaaccac ggugcuuuug gacagcaguc uggcgccauu uacgugggua     3840

acuacagagu gguaaauagg caccuggcca ccuaugccga uuggcagaau ugcguguggg     3900

aagauuauaa uagagaccuc uuagugagca caaccacagc gcacgggugu gacaccaucg     3960

cuagguguca augcugcacg ggugucuacu uuugugccuc aaggaacaag cacuacccag     4020

uuagcuuuga agggccaggc cuaguggaag uucaggagag ugaguauuac ccaaagagau     4080

accaguccca cgugcuguua gccgcagggu uuucugaacc aggagacugu gguggaauuc     4140

ucaggugcga gcaugguguu aucggacuag uuaccauggg uggcgaaggc guagucggcu     4200

uugcugaugu gcgcgaccug cugugguugg aggaugaugc aauggaacaa ggggucaagg     4260

guuauguaga acaauugggc aaugccuucg guuccggguu caccaaucaa aucugcgaac     4320

aagucaaccu ccucaaagaa ucacuagugg gccaagauuc cauacuagag aagucccuua     4380

aagcucuugu gaaaaucauu ucagcacugg uaauaguagu gaggaaccau gaugacuuaa     4440

uuacugugac ugccacccuc gcucuaauug gcugcaccuc aucgccgugg cgguggcuua     4500

aacagaaggu gucacaguau uacgggauac ccauggcuga gcgacaaaac aacggguggc     4560

ucaaaaaguu uacagagaug accaaugccu gcaaagggau ggaguggauu gccgucaaga     4620

uccaaaaguu uauagaaugg cucaagauua aaaucuuacc agagguaaag gagaagcaug     4680

aguuccuaac cagacuuaaa caacuccccc uucuggaaag ccaaauugcc accauugaac     4740

aaagugcacc gucccagagu gaucaggaac aacucuucuc aaauguucaa uacuucgccc     4800

acuacugcag aaaguacgca ccucuguaug cuacugaggc caaaagagug uucucccuug     4860

agaagaaaau gaguaacuac auacaguuca aguccaaaug ccguauugaa ccaguauguu     4920

ugcuauugca cgggaguccu ggagcuggga aaucgguugc caccaacuua auugggcgau     4980

cucuagcuga gaaguugaac aguucagugu auucucuacc accagacccu gaccacuucg     5040

auggcuauaa acaacaagcc guugugauua uggacgaccu augccaaaau ccagauggga     5100

aggauguguc auuauuuugu cagauggugu cgaguguuga cuuuguccca ccaauggcug     5160

ccuuggaaga aaaaggaauu uuguuuaccu cucccuuugu cuuggccuca acuaaugcug     5220

guuccaucaa ugccccgacg gugucagaca gcagggcuuu ggcuagaaga uuccacuuug     5280

acaugaacau cgagguuaua ucaauguaca gccagaaugg caagauuaac augcccaugu     5340

cagucaaaac augcgacgaa gagugcuguc caguuaacuu caaaaagugu ugcccccuug     5400

uguguggaaa agccauacag uuuauagaua gaagaacuca agugagguac uccuuggaca     5460

uguuggucac ugagauguuu agggaguaca accauaggca cagcgucggg gcaacccuug     5520

aggcacuauu ucaaggucca ccaguauaca gggagaucaa aauuacuguu gcaccugaua     5580

ccccaccacc accagcuauu gcauaccuac ugaaaucauu ggacagugaa gcaguuaggg     5640

aguacuguaa agagaaugga uggcucguuc cugaaauuag cucuacccuu cauauugaaa     5700

aacauguaag ccgagccuuu aucugucucc aggcacugac aacuuuugua uccguggccg     5760

guauuaucua caucauuuau aaacuauuug caggguuuca aggcgccuac acagggaugc     5820

ccaaccaaaa gccaaaaaua cccacacuaa ggcaagccaa ggugcaggga ccugcuugug     5880

aguuugcugu agccaugaug aagagaaacu ccaucacagu gaagacagag uauggugagu     5940

uuacaauguu gggcaucuac gacagguggg ccguacuacc acgccaugca aaacccgggc     6000

caaccauccu uaugaaugac caggaaguug gcguacuaga ugcaaaagaa cuaguggaua     6060

aagauggcac aaaccuugaa cugacgcugu ugaagcuuga ccggaaugaa aaguucagag     6120

acaucagagg uuuccuggcc aaggaagaag uggaggucaa ugaagcuguu cuagcaauaa     6180

acaccagcaa guucccgaac auguacauac caguugggca aguaacagac uacgguuucc     6240

ugaaccuggg gggcacuccg acgaaaagaa ugcucaugua caauuuuccu accagagcug     6300

gccaaugugg ugguauucuu augucuacug guaagguguu ggggauacac guugguggaa     6360

auggccacca gggcuucuca gcagcucucc uuaaacacua cuucaaugau gaacaaggug     6420

agauugaauu uauugaaagc ucaaaggaag cagguuuccc agucauuaau acuccaagca     6480

agacuaaauu ggaaccaagu gucuuccacc aaguguuuga aggcaacaag gaaccugcag     6540

uucucaggaa uggugaucca cgacucaaag caaauuuuga ggaggcaauc uuuuccaaau     6600

auauugguaa ugugaacaca cacguagaug aguacaugau ggaagccgug gaucacuacg     6660

caggacaauu ggccacacug gacauuaaua cggaaccuau gaaauuggag gaugcagugu     6720

auggcacaga gggguuggag gcacuugauc uaaccaccag ugcaggguac ccguauguag     6780

cacugggcau caagaagaga gacaucuugu cuaagaagac cagagaucug acuaaauuaa     6840

aggaguguau ggacaaauau ggucuaaacc uuccgauggu gaccuaugug aaggaugagc     6900

ucagaucagc agaaaaagug gcuaaaggca agucuagacu uauugaggca uccagccuga     6960

acgacucugu agcgaugaga caaacuuuug gcaaucugua cagaacauuu cauuugaacc     7020

cagggauugu aacuggcagu gcaguugggu gugauccuga ccuuuucugg agcaaaauac     7080

cuguaaugcu agauggacau cucauagccu uugauuacuc uggauaugau gccaguuuga     7140

gccccgugug guuugcuugu uugaagcuau ugcuagaaaa acuaggauac ucacacaaag     7200

aaacaaauua cauugacuau uugugcaauu cccaccauuu guacagagac aagcauuacu     7260

ucgugcgugg cggcaugcca ucagguugcu ccgguaccag caucuucaac ucaaugauca     7320

acaacaucau aaucaggacg cuaauguuga agguguacaa aggaauugac cuggaucgau     7380

ucagaaugau ugccuauggc gaugauguua uugcgucuua ccccuggcca aucgaugccu     7440

cuuuacuugc ugaagccggc aagggguaug ggcugaucau gacaccagca gauaaagggg     7500

aguguuuuaa ugaagucacc uggacuaaug ucaccuuuuu gaagagauau uucagagcag     7560

augagcaaua ccccuuugug guccauccug uuaucccaau gaaagacauc caugaaucaa     7620

uuagauggac aaaagaccca aagaacaccc aagaccaugu gcgcucuuug ugcuuguugg     7680

ccuggcacaa uggggagcac gaauaugagg aauucaucaa gaagaucaga agcgucccag     7740

ucgggcgcug ucuaacccuu ccugcguuuu ggacccugcg caggaaaugg uuggauuccu     7800

uuuagauuag agacaauuuu cugcaauuug aauuggcuua acccuaccac acucaccgaa     7860

cuagacaacg gugugguagg gguaaauucu ccgcauucgg ugcgg                     7905


<210>  16
<211>  8271
<212>  RNA
<213>  ˹

<220>
<223>  ECHO25-Anti-PD1Ļ

<400>  16
uuaaaacagc cuguggguug uucccaccca uagggcccac ugggcgcuag cacacuggua       60

uugugguacc uuugugcgcc uguuuuaucu accccucccc caaacgugac uuagaagcuc      120

aacacaugug gucagcaggu ggcccaguau accaacuggg ucuugaucaa gcacuucugu      180

uaccccggac cgaguaucaa uaggcugcuc acgcggcuga aggagaaagu guucguuauc      240

cggccaauua cuacgagaaa ccuaguacca ccauggaagu ugcgcggcgu uucgcuccgc      300

acaaccccag uguagaucag gccgaugagu caccgcacuc cucacgggcg accguggcgg      360

uggcugcgcu ggcggccugc ccauggggca acccauggga cgcuucaaua ccgacauggu      420

gugaagaguc uauugugcua auugguaauc cuccggcccc ugaaugcggc uaaucccaac      480

ugcggagcag auacccacau gccagugggc agucugucgu aacggguaac ucugcagcgg      540

aaccgacuac uuuggguguc cguguuucuu uuuauucuuu auuggcugcu uauggugaca      600

auugagagau uguugccaua uagcuauugg auuggccauc cggugacaaa cagaacaaua      660

guuuaucuau uuguugguuu cauaccauua aauuuuaaag uauuaaagac uaucaacuug      720

aucauacuac uuaauacagc aaaaugggag cucauguguc aacgcagaaa accggagcgc      780

augagacugg uuugagcgcc agugggaauu cgguuauuca uuacacaaca ucaauuauua      840

caaggaugca ucuucaaauu cagcaaacag gcaagacuuu ucacaagacc ccagcaaauu      900

uaccgaaccc uaugaaggau gucaugauua aaucacuccc ggcguuaaau ucacccacug      960

uggaggaaug uggcuacagu gaccgggugc gcuccauuac uuuggguaau ucaacaauca     1020

cuacgcagga aagugcaaau gugguaguug gcuauggugu cuggccggag uauuugaggg     1080

augaggaagc cacggcacaa gaccaaccca cucaaccaga uguugccacc uguagauucu     1140

acacccuaga aucuguuaug ugggagaagu ccucggcggg cugguggugg aaguuuccag     1200

augcucuugc agagaugggc cuauucgguc aaaauaugcu auaccauuau uugggaaggu     1260

caggcuacac aauacacgug caaugcaaug cgucaaaauu ccaccaaggg ugccuucuug     1320

uagucugugu gccagaagcc gagauggguu cugcacagcu ugauaggaca uugaaucaua     1380

ccaaacuuag caacacagaa cacgccagca cauucggguc caugaguucc aaugaagcug     1440

gggccgucca aaauguagug cacaaugccg ggaugggcgu uggagugggu aacuugacca     1500

ucuacccuca ucaguggauu aaucuuagaa ccaacaauug ugccaccaua guaaugccgu     1560

acauaaacag ugugccaaug gauaauaugu uuaggcauua caauuucacc cuuaugguga     1620

uuccauucgc acagcuugau uaugcaccca gcgcguccac ucacguucca auaaccguga     1680

caguugcccc caugugugcc gaauacaacg ggcuaagauu ggcagguaaa cagggcuuac     1740

caacaaugcu cacuccaggu agcaaccagu uccucacguc ugaugauuuc caguccccau     1800

cagcaaugcc acaguuugau guaacgccgg agauugaaau ccccggugac gugaagaauu     1860

uaauggaaau ggcugaaguu gauucugugg ucccagugaa uaaucuggau gauaagguaa     1920

auucaauuga agcuuauaca auccccguca aaucaaugag ugguauugcg acacaagucg     1980

uuggguucca auuacaaccc ggggacgaua gugcguuuaa gaggacacug uuaggagaga     2040

uuuugaacua cuuugcaaau uggucgggaa uuaucaaacu gacauuccca uacugcggug     2100

cggcgaugac cacuggcaca uuccugaucg ccuacucccc uccuggugcu ggcuucccug     2160

cuaaccgcaa ggacucaaug uugggcacuc acauugucug ggacauagga uugcaaucga     2220

guugugugcu cugcgugcca uggaucaguc agacaaacua ccgcuucgug acgcaugacg     2280

cuuauacaga cgcuggguuu auuacaugcu gguaccaaac aaacauagug ucacccccag     2340

acaucccggc agacaguaca auccuauguu uuguuucagc uuguaaugau uucucggugc     2400

gcuuguuaag ggacacgcca uucauaucac aaaacgcacu ucuccaaaau gacccggcua     2460

cugccauugu uagaucagug gaacgggugg ccgauaccau agcaaguggc ccaaugaauu     2520

ccgagagagu cccagcauug acugccgucg agacggguca cacaucucaa guuguuccca     2580

gugauacuau gcaaaccagg cauguuguua accaucacau uagaucggaa ucuucaauag     2640

agaauuuucu gaguagaucg gcaugcguuu acauugaugu guauggcaca aaagagaaug     2700

gugacaucga acguuucacu aacuggaaga ucaacacacg ccagguuguu cagcugaggc     2760

gcaagcugga gauguucacu uacaucagau uugaugugga aauaacauuc guaauuacaa     2820

guacucaagg gacaucaacc caaacaagca cuggcacccc agugcucaca caucaaguga     2880

uguaugugcc acccggaggc cccauacccg cgucauauga ggauuauagc uggcaaacuu     2940

cgacaaaccc cagcguuuuc uggacagaag ggaaugcacc ggcucgcaug ucaauacccu     3000

uuaugagugu gggcaaugcc uauugcaacu uuuaugaugg cuggucacau uucucgcaau     3060

ccggcgugua ugguuucacu acccugaaca acaugggaca gcuguuuuuc agacauguga     3120

auaaggacac acuuggcccu uacaacagca cagugcgugu cuauuucaaa ccaaagcaca     3180

ucaaagcaug ggugcccaga ccaccgcguc uaugcgauua uguguaugca cauaaugucg     3240

auuucacccc cagaggaguc acggacauaa gggaaaagau cacacuggaa agagacgacc     3300

acacgccuuc gaugguaaac cacggugcuu uuggacagca gaugaagcac cugugguucu     3360

uccugcugcu gguggccgcu ccuagguggg ugcuguccca ggugcagcug gugcagagcg     3420

gcguggaggu gaagaagccc ggcgcuuccg ugaagguguc cugcaaggcc uccggcuaca     3480

ccuucaccaa cuacuacaug uacuggguga ggcaggcccc uggacaggga cuggagugga     3540

ugggcggcau caacccuucc aacggcggca ccaacuucaa cgagaaguuc aagaaccggg     3600

ugacccugac caccgacucc uccaccacca ccgccuacau ggagcugaag ucccugcagu     3660

uugacgacac cgccguguac uacugcgcca ggagggacua ccgguucgac augggcuucg     3720

acuacugggg ccagggcaca accgugaccg uguccagcgg agguggcgga ucuggagggg     3780

gugguagcgg uggaggcggg agugagaucg ugcugaccca guccccugcu acacuguccc     3840

ugucccccgg cgagagggcu acacugagcu gcagggccuc caagggcgug uccaccuccg     3900

gcuacuccua ccugcacugg uaccagcaga agccuggaca ggcucccagg cugcugaucu     3960

accuggccuc cuaccuggag uccggcgugc cugcuagguu uuccggcagc ggcagcggca     4020

ccgauuucac ccugaccauc uccucccugg agcccgagga cuucgccgug uacuacugcc     4080

agcacuccag ggaucugccu cugaccuucg gcggcggcac caagguggag aucaaggacg     4140

accacacgcc uucgauggua aaccacggug cuuuuggaca gcagucuggc gccauuuacg     4200

uggguaacua cagaguggua aauaggcacc uggccaccua ugccgauugg cagaauugcg     4260

ugugggaaga uuauaauaga gaccucuuag ugagcacaac cacagcgcac gggugugaca     4320

ccaucgcuag gugucaaugc ugcacgggug ucuacuuuug ugccucaagg aacaagcacu     4380

acccaguuag cuuugaaggg ccaggccuag uggaaguuca ggagagugag uauuacccaa     4440

agagauacca gucccacgug cuguuagccg caggguuuuc ugaaccagga gacuguggug     4500

gaauucucag gugcgagcau gguguuaucg gacuaguuac cauggguggc gaaggcguag     4560

ucggcuuugc ugaugugcgc gaccugcugu gguuggagga ugaugcaaug gaacaagggg     4620

ucaaggguua uguagaacaa uugggcaaug ccuucgguuc cggguucacc aaucaaaucu     4680

gcgaacaagu caaccuccuc aaagaaucac uagugggcca agauuccaua cuagagaagu     4740

cccuuaaagc ucuugugaaa aucauuucag cacugguaau aguagugagg aaccaugaug     4800

acuuaauuac ugugacugcc acccucgcuc uaauuggcug caccucaucg ccguggcggu     4860

ggcuuaaaca gaagguguca caguauuacg ggauacccau ggcugagcga caaaacaacg     4920

gguggcucaa aaaguuuaca gagaugacca augccugcaa agggauggag uggauugccg     4980

ucaagaucca aaaguuuaua gaauggcuca agauuaaaau cuuaccagag guaaaggaga     5040

agcaugaguu ccuaaccaga cuuaaacaac ucccccuucu ggaaagccaa auugccacca     5100

uugaacaaag ugcaccgucc cagagugauc aggaacaacu cuucucaaau guucaauacu     5160

ucgcccacua cugcagaaag uacgcaccuc uguaugcuac ugaggccaaa agaguguucu     5220

cccuugagaa gaaaaugagu aacuacauac aguucaaguc caaaugccgu auugaaccag     5280

uauguuugcu auugcacggg aguccuggag cugggaaauc gguugccacc aacuuaauug     5340

ggcgaucucu agcugagaag uugaacaguu caguguauuc ucuaccacca gacccugacc     5400

acuucgaugg cuauaaacaa caagccguug ugauuaugga cgaccuaugc caaaauccag     5460

augggaagga ugugucauua uuuugucaga uggugucgag uguugacuuu gucccaccaa     5520

uggcugccuu ggaagaaaaa ggaauuuugu uuaccucucc cuuugucuug gccucaacua     5580

augcugguuc caucaaugcc ccgacggugu cagacagcag ggcuuuggcu agaagauucc     5640

acuuugacau gaacaucgag guuauaucaa uguacagcca gaauggcaag auuaacaugc     5700

ccaugucagu caaaacaugc gacgaagagu gcuguccagu uaacuucaaa aaguguugcc     5760

cccuugugug uggaaaagcc auacaguuua uagauagaag aacucaagug agguacuccu     5820

uggacauguu ggucacugag auguuuaggg aguacaacca uaggcacagc gucggggcaa     5880

cccuugaggc acuauuucaa gguccaccag uauacaggga gaucaaaauu acuguugcac     5940

cugauacccc accaccacca gcuauugcau accuacugaa aucauuggac agugaagcag     6000

uuagggagua cuguaaagag aauggauggc ucguuccuga aauuagcucu acccuucaua     6060

uugaaaaaca uguaagccga gccuuuaucu gucuccaggc acugacaacu uuuguauccg     6120

uggccgguau uaucuacauc auuuauaaac uauuugcagg guuucaaggc gccuacacag     6180

ggaugcccaa ccaaaagcca aaaauaccca cacuaaggca agccaaggug cagggaccug     6240

cuugugaguu ugcuguagcc augaugaaga gaaacuccau cacagugaag acagaguaug     6300

gugaguuuac aauguugggc aucuacgaca ggugggccgu acuaccacgc caugcaaaac     6360

ccgggccaac cauccuuaug aaugaccagg aaguuggcgu acuagaugca aaagaacuag     6420

uggauaaaga uggcacaaac cuugaacuga cgcuguugaa gcuugaccgg aaugaaaagu     6480

ucagagacau cagagguuuc cuggccaagg aagaagugga ggucaaugaa gcuguucuag     6540

caauaaacac cagcaaguuc ccgaacaugu acauaccagu ugggcaagua acagacuacg     6600

guuuccugaa ccuggggggc acuccgacga aaagaaugcu cauguacaau uuuccuacca     6660

gagcuggcca augugguggu auucuuaugu cuacugguaa gguguugggg auacacguug     6720

guggaaaugg ccaccagggc uucucagcag cucuccuuaa acacuacuuc aaugaugaac     6780

aaggugagau ugaauuuauu gaaagcucaa aggaagcagg uuucccaguc auuaauacuc     6840

caagcaagac uaaauuggaa ccaagugucu uccaccaagu guuugaaggc aacaaggaac     6900

cugcaguucu caggaauggu gauccacgac ucaaagcaaa uuuugaggag gcaaucuuuu     6960

ccaaauauau ugguaaugug aacacacacg uagaugagua caugauggaa gccguggauc     7020

acuacgcagg acaauuggcc acacuggaca uuaauacgga accuaugaaa uuggaggaug     7080

caguguaugg cacagagggg uuggaggcac uugaucuaac caccagugca ggguacccgu     7140

auguagcacu gggcaucaag aagagagaca ucuugucuaa gaagaccaga gaucugacua     7200

aauuaaagga guguauggac aaauaugguc uaaaccuucc gauggugacc uaugugaagg     7260

augagcucag aucagcagaa aaaguggcua aaggcaaguc uagacuuauu gaggcaucca     7320

gccugaacga cucuguagcg augagacaaa cuuuuggcaa ucuguacaga acauuucauu     7380

ugaacccagg gauuguaacu ggcagugcag uuggguguga uccugaccuu uucuggagca     7440

aaauaccugu aaugcuagau ggacaucuca uagccuuuga uuacucugga uaugaugcca     7500

guuugagccc cgugugguuu gcuuguuuga agcuauugcu agaaaaacua ggauacucac     7560

acaaagaaac aaauuacauu gacuauuugu gcaauuccca ccauuuguac agagacaagc     7620

auuacuucgu gcguggcggc augccaucag guugcuccgg uaccagcauc uucaacucaa     7680

ugaucaacaa caucauaauc aggacgcuaa uguugaaggu guacaaagga auugaccugg     7740

aucgauucag aaugauugcc uauggcgaug auguuauugc gucuuacccc uggccaaucg     7800

augccucuuu acuugcugaa gccggcaagg gguaugggcu gaucaugaca ccagcagaua     7860

aaggggagug uuuuaaugaa gucaccugga cuaaugucac cuuuuugaag agauauuuca     7920

gagcagauga gcaauacccc uuuguggucc auccuguuau cccaaugaaa gacauccaug     7980

aaucaauuag auggacaaaa gacccaaaga acacccaaga ccaugugcgc ucuuugugcu     8040

uguuggccug gcacaauggg gagcacgaau augaggaauu caucaagaag aucagaagcg     8100

ucccagucgg gcgcugucua acccuuccug cguuuuggac ccugcgcagg aaaugguugg     8160

auuccuuuua gauuagagac aauuuucugc aauuugaauu ggcuuaaccc uaccacacuc     8220

accgaacuag acaacggugu gguaggggua aauucuccgc auucggugcg g              8271


<210>  17
<211>  22
<212>  DNA
<213>  ˹

<220>
<223>  miR-133еDNA

<400>  17
acagctggtt gaaggggacc aa                                                22


<210>  18
<211>  22
<212>  DNA
<213>  ˹

<220>
<223>  miR-206еDNA

<400>  18
ccacacactt ccttacattc ca                                                22


<210>  19
<211>  102
<212>  DNA
<213>  ˹

<220>
<223>  miR-133miR-206еĴеDNA

<400>  19
acagctggtt gaaggggacc aacgatacag ctggttgaag gggaccaaac cggtccacac       60

acttccttac attccatcac ccacacactt ccttacattc ca                         102


<210>  20
<211>  507
<212>  DNA
<213>  ˹

<220>
<223>  HRV2ڲλеDNA

<400>  20
aacttagaag tttttcacaa agaccaatag ccggtaatca gccagattac tgaaggtcaa       60

gcacttctgt ttccccggtc aatgttgata tgctccaaca gggcaaaaac aactgcgatc      120

gttaaccgca aagcgcctac gcaaagctta gtagcatctt tgaaatcgtt tggctggtcg      180

atccgccatt tcccctggta gacctggcag atgaggctag aaatacccca ctggcgacag      240

tgttctagcc tgcgtggctg cctgcacacc ctatgggtgt gaagccaaac aatggacaag      300

gtgtgaagag ccccgtgtgc tcgctttgag tcctccggcc cctgaatgtg gctaacctta      360

accctgcagc tagagcacgt aacccaatgt gtatctagtc gtaatgagca attgcgggat      420

gggaccaact actttgggtg tccgtgtttc actttttcct ttatatttgc ttatggtgac      480

aatatataca atatatatat tggcacc                                          507


