                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> NUCLEIC ACIDS THAT MANIPULATE IMMUNE PATHWAYS

<130> 048218-555001WO

<140> PCT/US2018/032479
<141> 2018-05-12

<150> 62/505,819
<151> 2017-05-12

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 39
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Signaling or targeting protein

<400> 1
Val Thr Met Asn Ala Pro Met Thr Ser Val Ala Pro Pro Pro Ser Val 
1               5                   10                  15      


Leu Ser Gln Glu Pro Arg Leu Leu Ile Ser Gly Met Asp Gln Pro Leu 
            20                  25                  30          


Pro Leu Arg Thr Asp Leu Ile 
        35                  


<210> 2
<211> 540
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Tyr Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gly Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210> 3
<211> 540
<212> PRT
<213> Homo sapiens

<400> 3
Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210> 4
<211> 540
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe 
1               5                   10                  15      


Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro 
            20                  25                  30          


Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu 
        35                  40                  45              


Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg 
    50                  55                  60                  


Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu 
65                  70                  75                  80  


Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln 
                85                  90                  95      


Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu 
            100                 105                 110         


Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile 
        115                 120                 125             


Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val 
    130                 135                 140                 


Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala 
145                 150                 155                 160 


Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly 
                165                 170                 175     


Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser 
            180                 185                 190         


Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala 
        195                 200                 205             


Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser 
    210                 215                 220                 


Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu 
225                 230                 235                 240 


Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser 
                245                 250                 255     


Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly 
            260                 265                 270         


Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu 
        275                 280                 285             


Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro 
    290                 295                 300                 


Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser 
305                 310                 315                 320 


Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val 
                325                 330                 335     


Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn 
            340                 345                 350         


Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val 
        355                 360                 365             


Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg 
    370                 375                 380                 


Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly 
385                 390                 395                 400 


Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser 
                405                 410                 415     


Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe 
            420                 425                 430         


Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly 
        435                 440                 445             


Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly 
    450                 455                 460                 


Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu 
465                 470                 475                 480 


Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln 
                485                 490                 495     


Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser 
            500                 505                 510         


Pro Gly Ala Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val 
        515                 520                 525             


Thr Leu Leu Val Val Leu Tyr Arg Arg Arg Leu His 
    530                 535                 540 


<210> 5
<211> 29325
<212> DNA
<213> Homo sapiens

<400> 5
acatggccaa tggccgcgcg ctctgcccgc cccgcctcct cgctgcggga agggtcctgg       60

gccccgggcg gcggtcgcca ggtctcaggg ccgggggtac ccgaggtaag atcgcttccc      120

gggcgttggg tcctttcggc tcagcacgca cggacgcctt tagggaaggt ggctgcagcg      180

gcaggacgga gtccgccggg acgccctggg tctggggtgc gcggggggcc caggagggga      240

caggacgcgc ggggatccgg aagagcgggc cctgtcgcaa gagtttcggg aacactgagg      300

gctccaggcg ccgcatccag catccgggga aaagggggta ggtggcgctg ggcgtctgct      360

caggctgggg gaaaggtagg gccagaaggg gacgggcagc ggccgctgac ctcctcctgc      420

cgcccgcggg cccagggtga cgctaaggtg gggccgagcc tcgaccgggt gcgcctagag      480

gtcgagtgct gccgccctcc gctgggtctg gacagttctc ggcggcgaca ccagctcaaa      540

acggcctccc cgccctccgc ggacctgggt cgcgcccagg aatccgatcc aaggctgtga      600

ggcctgtccc tttgggaagg gtgggtgttt atttccggga tgcactcaga gcctctggac      660

agtcaggtcg gaaactttgc tgtattggga acactctgtc acctacttcc ttctcagttg      720

ggaaggaagt gccaagaaaa catgaaacaa accaaaaaca cgaaaaaggg attctctgta      780

tggaagccgt gaagcctcaa aaatatctag gaggacagcc agcgacctgg gacctgtggc      840

agccatgtga aagcagggtt aatgtctgga ctaaatgttg cttccaccta agtgcaccct      900

cagcctccct cccgccaagt gaccttgggt cctctttggg cttgaaggca ggtggctgtg      960

tgggtctcgc tgcaggggtc tctgtgccct gcaaggtgta tgaccagttg cagtgaggca     1020

gcaggttttg ggttcaaatc ctgtgctagc ctctggccag ctgtgcacct tggcaacact     1080

ttccctgtca cgggattggg gaaggattaa ctgaaagaac cttaggatgt gcctgtctac     1140

aatgggccct ccataaatgt gaacaaatgt gggcttcctt tccttttgtt tgggccacat     1200

catcccttcc cctccatctg tggctgaagc tggaatgcag aagagtgcct catctgactg     1260

ccttctggta cctggctgat gccatgagaa aggaaggaga aaggggtctt tttttttttg     1320

aaatggagtc tcactctctt gcccaggctg gagcgcagtg gtccaatctt ggctcactgc     1380

aacctctgcc tcctgggtct agagattctc ctgcctcagc ctcctgagta gctgggacta     1440

caggtgtgtg ccaccatgcc tggctaattt ttgcattttt agtagagacg gggtttcacc     1500

atgttggcca ggctggtctc aaactcctga cctcaagtga tctgcctgcc tcggcctccc     1560

aaagtgctgg gattccaggc gtgagccacc gcgcccggcc gagaaaggga tctattaact     1620

cccatagagt tgttctttgc taatttcttg aaggctcaga ggacccccgc ctcaccttcc     1680

tgattctcct gacctgtcat tagtacttgc cccacgagga atgtagcagg gcctgctggc     1740

tggcaaagca actcatgcat gtgaggctct gaggccagtg acaggactgc ttcccctgtg     1800

aggaaggtct ggtggcccaa cagcttttag gtgctgtctg ctctacagca ctgcctcctg     1860

agagaggtct catgcctgcc tgatgcccac ttggtcctct cctgcctcct tccctccctg     1920

acaacccact tggaatccaa tagcatctca aacttcactt gttccgaact gagttctgga     1980

gtcccttctg agccactgct cctcccctgg cttctctggc ctggtaaaag ggcaccttcc     2040

atccacccag tgcccaagga gtcatgcttc ttttctctcc cttatctcct acaccctcaa     2100

aacaccagga atctggctgc ctcctgccat ctctgtggtt cccatcctga ccatagtcat     2160

cctgtctcct gggctgtggc ctccttactg gtctcccagt tttcatcctg gcccctccaa     2220

agtcctcaca accaccagag aagtctttaa tgtaaatcag atcctcttct ttccctgccg     2280

gaaccttcca gtggttccct gtttcactcc aactaaaacc cagagtcctt tcctacagca     2340

ctctacatga gtggcccctg ccacctcctt gaccttgaca atctctgccc ctttccctag     2400

cttgcttgct tttttttttt tttttcctat gatggagttt tgatcttgtc acccaggctg     2460

gagtgcaatg ggatgatttc agctcactgc aacctctgcc tcctgggttc aagcgattct     2520

cctgcctcag cctcccgagt agctgggatt acaggcgccc accaccatgc taatttttgt     2580

atttttagta gagaaagggt ttcaccatgt tggcgaggct ggtctcaacc tcctgagctc     2640

aggtgatcca cccgcctagg cctcccaaag tgctgggatt ataggcgtga gtcacgcagc     2700

cagccatccc tagctttctt gacctagacc acactgacct gctttctatt cttcaaacat     2760

gccaagctca ttcttgtttt aggacttttg catttaccat gctctctgcc taaaacacca     2820

atcttctcag agcctgagaa cagctcagct gtgttctgca cgctagttca gaaaggcttc     2880

tttgaccccc tagttcaagt agcatgcctg tctccagggg ctctgtctca ttacctgctt     2940

tactttcttt agagccttta ttgctatctg gaactcttat ttgggtatta atttactgat     3000

ctgttatttg tcccacccca ttagaatata aattggatgt ggcatagacc ttgtctcttt     3060

tattccctgc agcactccct gatgggggcg gcagaaaagt aacgagcaaa tacatctata     3120

actgcaaatt gtggtaactc ctacataaac aactggcagc aattgcttat atttgaggca     3180

cttaaaaatt tttaagctgg ctgggcgcgg tggctcatgc ctgtaatccc agcactttgg     3240

gaggccgagg cgggcagatc acgaggtcag gagatcgaga ccatcctggc taacacggtg     3300

aaacctgtct ctactaaaaa tacaaaaaat tagccgagcg tggtagcagg cgcctgtagt     3360

cccagctact tgggaggctg aggcaggaga atggtgtgaa cccgggaggc ggagcttgca     3420

gtgagccgag attgcaccac tgcactccag cctgggtgaa ggagcgagac tgtctcaaaa     3480

aaaaaaaaaa aaaaaaaaaa agaaattttt ttaagctgct gggcgcggtg gctcacgcct     3540

gtaaatctca gcactttggg aggccgaggt gagcggatca cctgaggtcg ggagttcgag     3600

accggaacat ggtgaaaccc tgtctctact aaaaatacaa aattagcggg gcgtggtggc     3660

tcatgcctgt aatcccagct acttgggagg ctgaggcagg agaatcgctt gaacccagga     3720

ggcagaggtt gcagtgagcc gagatcgcgc cattgtactc cagcctgggc aaaaagagtg     3780

aactccattt caaaaaaaaa aaaaaaggcc aggcgcagtg gctcacgcct gtaatcccag     3840

cactttggga ggccgaggca ggcggatcac gagttcagga gattgagacc atcctggcta     3900

acacggtgaa accctatctc tactaaaaat acaaaaaatt agccgggtgt ggtggcgggc     3960

gcctgtggtc ccagctactc gggaggctga ggcaggagaa tggtgtgaac ccaggaggtg     4020

gagcttgcag tgagccgaga ttgcaccaca gcactccagc tttggtgaca gagcgaaact     4080

ccgtctcaaa aaaaaaaaaa aaaaaaattt aagcttagag gccggccaca gtggctcagc     4140

actgtgcagg ccaaggcaag aggatcactt gaggtcaaga gttcgagacc agcctggcca     4200

acatggtgaa accctgtctc tactaaaaaa tacaaaaatt ggccaggcgc gttggctggc     4260

gcctgtaatc ctagcaactt gggagaccaa ggcaggcaga tcacctgggg tcaggagttc     4320

aggaccggcc tggccaacat taaaacatat aaaaccccgt ctctactaaa aatataaaaa     4380

ttatccaggc atggtggcgt gtacccgtaa tcccagctac tcgggaggct gaggtaggag     4440

aattgcttaa acccgagaag cagaggttgc agtgaaccga gattacgcca ctgcactcca     4500

gcctgggcaa cagagcgaga ctctttctca aaaacaacaa caacaacaaa caaacaaatt     4560

agccaggcat gatggtgggc acgtgtaatc ccagctactc gggaggctga ggcaggagaa     4620

ttgcttgaat gtgggagatg gaggctgcag tgagccgaga tcacaccact gcactccagc     4680

ctgggcgaca gggagactct gtctcaaaaa aaaaaaaaaa aaaaaaagtt tataaggctg     4740

aattaccgta ctgtcaaaac aagctgctat ctgagccgtt ttaagggtga ggaagtctgg     4800

aaactgataa cttgcccagg acacacagtg agttcaaggc atggaactca gtctcctatc     4860

ttaagaatgt atgtgggccg ggcatggtgg ctcacgcctg taatcccagc gctttgggag     4920

gccaaggcag gcagatcatc tgaggtcagg agttcaagac cagcctgacc aacatggaga     4980

aaccctgtct ctactaaaaa tacaaaatta accaggtgtg gtggtgcatg tctgtaattc     5040

cagctactca ggaggctgag gcagaagaat cacttgaacc cggaaggcag aggttgcgat     5100

gagccgagat tgtgccattg tactccagcc tgggcaacaa gagtctggaa ctctgtctca     5160

aaaaagaaaa aaagaatgta tgtgtagcag gctttttttt tttttttttc ccccgagacg     5220

gaatctggct ctgtcgccca ggctggagtg cagtggcgca atcttggctc actgcaagct     5280

ccgcctccca ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactacagg     5340

cacccgccag tacgccgggc taattttttg tatttttagt agagacgggg tttcaccgtg     5400

ttagccagga tggtcttgat ctcctgacct cgtgatccac ccgcctcggc ctcccaaagt     5460

gctgggatta caggcgtgag ccaccgtgcc cggcctatgt gtagcaggct ttaatggtgg     5520

gcctgcagcc atgtcatgga aagaagctga cctgaagatc tcagttcttt cttcttctac     5580

taactagcaa gcatacctca gtttcttctt taaagcggga tgatccgatt attatcatgt     5640

tggggttcac tttttatttt ttcagtgtgt cccaaagcag cagcacgttt aggtatagcc     5700

ctcttgctat cagcttgagg gccttagagc caggaaggga gccaggacat ttataggcac     5760

agaaactagg gtcacataca gatcccccca ccgcatgtgc taggggtaca tgcagacctt     5820

cccagtgctg accaacctgc agagaagaaa tgggccctag gtattctgga tctgattctt     5880

tttggtcttc aattattttt atttttattt ttttagagac agggtctcgc tgtgttgccc     5940

aggctggcct cgaacagctg ggctcaagcg atcctcctgc cctagcttct tgagtagctg     6000

gtggtcatca attcattttt agcaaattct gcagaatttt tttttttttt tttttttttg     6060

agacggagtc tcactctgcc gcccaggctg gagtgcagtg gcgtgatctc ggctcactac     6120

aacctccgcc tcttgggttc aagcaattct ctgtctcagc ttcctgaata gctgggactg     6180

caggcgcccg ccaccatgct tggctaattt ttttgtattt tcagtagaga cggggtttca     6240

ccatcttggc caagttggta ttgaactcct gacctcgtga tccatccgcc tcggcctccc     6300

aacgtgctgg ggttacaggc gtgagccacc gcgcccgggt tctgcaggaa ttttggagag     6360

actcaggcag taataaaata ggatgtttac agaaattaaa gatggcggcc gggcgcggtg     6420

gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcgcatcac gaggtcagta     6480

aatcgagacc atcctggcta accccgtgaa accccgtctc tactaaaata caaaaaaatt     6540

agccgggcgt ggtggcgggc gcctgtcgtc ccagctactc aggaggctga ggcaggagaa     6600

tggcgtgaac ccgagaggcg gagcttgcag tgagccgaga tcgcgccacc gcactccagc     6660

ctgggcgaca gagaaagact ccgtctcaaa aaaaaaaaaa agaaattaaa ggtggctgga     6720

cacattggct ggtgcttgtc atccgagcta cttgacaggc ggaggcaggg ggatcgcttg     6780

aggccaggcg tttgagacca gcctgggcag catcatgaga ccctgtctct agaaaaaata     6840

aaaaaattag ctgggcatag tggcgcaggt ttgtagttcc agctaccggg gatgctgagg     6900

cgggaggatt gcttgagccc acgagttcga ggctgcagtg aactattatt gcaccactgc     6960

acccaacttg ggtgacagag accccatctg tttgtttgtt tgtttttgag acagagtttc     7020

gctcttgttg cccaggctgg agtgcaatgg tgcaatcttg gctcaccgca acctctgccc     7080

ccaggttcaa gcaattctcc tgcctcaacc tcccgagtag ctgggattac aggcatgcgc     7140

caccatgccc agctattttt tttttttttt tgtattttta gtagagacgg gattttctcc     7200

atgttggtca gtctggtctc caactcccga cctcagttaa tcccccaaat tggcctccca     7260

aagtgctggg attataggcg tgaaccactg tgcccagccc gagaccccat ctcttaaaaa     7320

caaaataaaa caaaacaaaa acggccaggt gtggtggctc acacctgtaa tccccaaact     7380

tgggaggccg aggcgggtgg accacttgag gtcaggagtc tgtgaccagc ttgccaacat     7440

ggtgaaaccc catctctact aaaaatacaa aaattagctg ggcatggtgg tgcgcacctg     7500

taatcccagc tactcagaag ggaggctgag gcaagagact caattgaacc caggaggcgg     7560

aggttgcagt gagccgagat tgccccactg cactccagcc tgggtgacaa agtgagactc     7620

gctctcaaaa aaaaaaaaaa gaagaaatta aagatgaaag aaaacaaaca ttccaaaaag     7680

ttgagaaaga attgcctttt gtccagcccc actcccaacc ccccaaccct gttgtaatgt     7740

gtgatctgtt ttcttccagt ctcgtttcct ctcagtccat ccacccttca tggggccaga     7800

gccctctctc cagaatctga gcagcaatgc cgtttgctga agacaagacc tataagtata     7860

tctgccgcaa tttcagcaat ttttgcaatg tggatgttgt agagattctg ccttacctgc     7920

cctgcctcac agcaagagac caggtgagca agggaagtga cagcccgaca ctggcctggg     7980

ggcagggctg tggaattcaa agctcagccc catcctagtt cctcacccaa gcctgggctg     8040

gctccttcct tcttcctctt gctgtgtctt gctccttgtc cttgctgctt ttcttttttt     8100

tttttttttt tgagattgag tctcgttctg tcgccaggct ggagtgcagt ggcacgatct     8160

tggctcattg caacctccgc ctcctgggtt caagtgattc tcctgcctca gcctcctgag     8220

tagctgggat tacaggtgcg tgccaccacg cccagctaat ttttttgttt ttaatagaga     8280

cggggtttca ccatgttggc caggatggtc ttgatctctt gaccttgtga tccgcctgcc     8340

tcggcctccc aaagtgctgg gattacaggc gtgagccacc gcacccttgc tgcttttcta     8400

acttttggat ggagtgtggc tcagggtggc gttgctgact tcgccgagct cccccttgtg     8460

ttgcttttgt gcactgctca aaaatatggc gctggctctc tgagatttcc tggctctggt     8520

ccacttgccc actttttttg gaacctccta tttccttcat ctctcttgcc cttccttgtc     8580

ctgctcagtt ttgattccat tctccttgtc atggggccct gtcctggcac ggagctggga     8640

ctcaggtttg agagctggca ggatcagggt cgctctagcc ccaacagaac ttgctgcagg     8700

cccctggcac tcactagctg gtgaaacggg cacaacccct ccccgttgta gctgctgttc     8760

tcagattgga cccctgtgct ccagagggta cctgttggct cttttggggc ctcctgtcct     8820

cagatttctc aggagcccca ttgttgtctc cgctgtcctc ccacacagat cgcattagta     8880

tgcaggtctg tttggagttt gctcctccct cttgtatttt ggggtttata gggatatctt     8940

gttttatagt aaatattttc tgtgggtttt ctttattttc tttaaaaaat ttttttttga     9000

gacggagtct cgctgtgttg cccaggctgc agtgcaatgg catgatctca gctcactgca     9060

acctctgcct cctgggttca agtgattctc gcgcctcagc ctcctgagta gctggggtta     9120

caggcgcatg ccaccacacc tggctgattt tgtatttgta gtagagatgg agtttcacca     9180

tgttggccag gctggtcttt atttttattt ttgagacaga gtcttgctct gtcactcagg     9240

ctggagtgca gtggcacgat tttttttttt ttttgagacg gagtctcact ctgtcgccca     9300

ggctggagtg cagtggtgtg atctcggctc actgcaagct ctgcctcctg ggttcacgcc     9360

attctcctgc ctcagcctct tgagtagatg ggactacagg cgcctgccac catgcccggc     9420

taattttttg tatttttaat agagacgggg tttcactgtg ttagccagga ttgtctcgat     9480

ctcctgacct catgatccac ccgcctcggc ctcccaaagt gctgggatta caggcgtgag     9540

ccactgcgcc cagcattttt tttttttttt tttttgagat ggagtctcgc tgtgtcttcc     9600

aggctggagt tgcagtggtg ccatcttggg tcaacctctg cctcctgggt tcaagcaatt     9660

ctcctgcttc agcctcctga gtagctggga ttacaggtat atgctaccac acccggctaa     9720

tttttgtgtt tttagtagag acggactttc accatgttgg tcaggctggt cttgaactcc     9780

tgaccttgtg atcctcggcc ttccaaagtg ctgggattac gggtgtgagc taccgcacct     9840

ggctattttc ctttttctaa aaatctagct cctgcaggat tctgtgggtt tttgtttctg     9900

ctgtctggtt gcttgttttt atgtgagaat tcaggtagac ataaaaactc tagggctggg     9960

cacggtggct cacgcctgta atcccagcgc tttgggaggc caaggcgggt ggatcacctg    10020

aggtcaggag ttcgagacca gcctggccaa catggcgaaa ccatgtctct actaaaaata    10080

caaaaaaatt agccgggtgt ggtggtgggc tcctgtaatc ccagctactc gggaggctga    10140

ggcaggagaa tcgcttgaac tcaggaggca gaggttgcag taagctgata tcacggcact    10200

gcactccagc ctgggcgacg gagtgggact ccgtctgaaa aaaaaaaaaa aaaaagaaac    10260

aaaaaaactc tgcagccact gtcatctgcc cacaatctcc ccagcattct cagcttcctt    10320

gtttgttatt gtcggccccc tctctttccg tcttttgccc ctttcatcat acttttgcta    10380

tctacctttt ccttctctcc taatccaaac ctttcttttt gccctggggg ccatattaat    10440

ccaaggcttt tgtatcagat taactgggtt tggattcctg ccccactgtt ttaggatctt    10500

tgctacagta ctttgcttct gctaagcctc agtttcctca ttagtaaagt ggagataata    10560

atggcattaa ataaagatga tacatgcaaa gcccttaatg gagagcccag gacatagtta    10620

attgccagtt tccggcagct gcctttattg atgtggctgc taattgctct tcctcactcc    10680

atacctggcc ctgtcctggg ctccgatcca gtttcacgtg gctgccttgc ccttgtggct    10740

ttcttggcac ccctcccccc gctgtggctt cattctgggt ggggaagtgg caggggccac    10800

ctggcttgag caggacagtg gcattgtgtc ttccaggatc gactgcgggc cacctgcaca    10860

ctctcaggga accgggacac cctctggcat ctcttcaata cccttcagcg gcggcccggc    10920

tgggtggagt acttcattgc ggcactgagg ggctgtgagc tagttgatct cgcggacgaa    10980

gtggcctctg tctaccagag ctaccagcct cgtgagcgtc ctgcccttgc cctcctggac    11040

ccccagcctg ctccctggcc tccgctctcc ttttctctct ccctgtactt cctgcctttc    11100

tctgtcatcc tctttcttgt cactgtgaag cgatgaataa acctgggtgt agatccaggc    11160

tgagccactt accagctgtg tccctttggc caagtccctt aatttccctg agcctcaggc    11220

ctctcttctg taaaatgaag ctcatggcag catctgccgc ggggagctgc agtgggtgat    11280

actgcgggac gatgcgtgtt gagtattgag ctgggctggg cacttcctgt atgcccagca    11340

catggagtct cccctaactt tcacggctgt agcattcgcc tcccaccctt cctcatttct    11400

tctcccccac ctactcattc accctccctc tctcctcctt ctcttcccct cccctggttt    11460

accctgagag ccttcgacgc cctctatcag ctgcccagtt attctttaag tccctctcag    11520

tgtccctgcc actctgagtg ctcggaggcg atttgatgag attgagtttg atcctgagtg    11580

agatcaagac atgggaggag gctgggcgcg gtgtttcaca cctgtaatcc cagcactttg    11640

ggaggccgag gcaggcggat catgaggtca ggagatggag accaccctgg ctaaaacagt    11700

gaaaccccgt ctctactaaa aatacagaaa attagccggg catgttgtcc cagctactca    11760

ggaggccgag gcaggagaat cacttgaacc agggaggcag aggttgcagt gagctgagat    11820

cgcgccactg cactccagcc tgggcgacag agtgggattc catctcaaaa aaaaaaaaaa    11880

aaagacatgg gaaaaaaaat caagccagcc ctatttatat ttcaaactag aggtaacccc    11940

cgagaccctg gtcacattta tagctgtggg acatccatgt ttttcttttc tttctctctc    12000

tttttttttt ttccttttag agacagagtc ttgctgcgcc acccaggctg cagtgcagtg    12060

gtgcaatcat agctcactgc agccttgacc tcctggactc aagtgatcct tctacctcag    12120

cctccagagt agctgggact acaggcatgg acaactacac ctggctaatt tttaaatttt    12180

ttgtagagat gacatctcac tatgttgccc aggctggtct caaactcctg ggctgaagcg    12240

atcggcctcc cagagtgctg ggatcatagg tgtgagccac cgcgtctggc tctcatgctt    12300

gcttttctct cctttttccc ttccttgctt ttcctccctc cctccctccc ttcctctctt    12360

ccttcctttt tttccttcct tctttttaaa tatgtctctt catgtgtgga gattaatagt    12420

gatccctggc tgggcacggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc    12480

gggcggatca caaggtcagg agttcgagac cagcctggcc aatatggtga aaccctgtct    12540

gtaccaaaaa tacaaaaaaa ttagctgcgc atggtggtgc aagcctgtaa tcccagctac    12600

ttgggaggct gaggcaggag aattgcttga accggggagg tggaggttgc agtgagccga    12660

gattgcgcca ctgcactcca gcctggatga cagagtgaga ctccgtctcc aaaaaaaaaa    12720

aacccaaaaa tagtgatccc ctgaatacaa tggctgtggt agggcctgat gaggggtggg    12780

ggcaaagggg aggggctcag gtggcagcat cagggcaggg gtcagtgagc aatgatagtc    12840

atgtggagga gaaagccact gggtcctagg atgcctgggg acagagaaga gtgactgctg    12900

acacggcgtg ggtgactaga gacccacgag gcccccccat actccccttc ctcccttgct    12960

accttgtcct ccatctgctc tcaccctccc actcctgccc ccttgccaag tgatgcttgt    13020

cactcctttt ttttttgaaa tggagtttcg ctctgtcgcc caggctggag tgcagtggtg    13080

ccatctcagc tcactgcaag ctccgcctcc cgggttcacg ccattctcct gcctcagcct    13140

cccgagtagc tgggactaca ggcgcctgca accatgcccg gctaactttt tgtatttttt    13200

agtagagatg gggtttcacc gtgttagcca ggatggtctc gatctcctga cctcgtgatc    13260

cacccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccaa gcccagccct    13320

gcttgtcact cttgaggagt gggcccacat cagaacagct tttggaccta tgggtggggc    13380

ggggggtgta cccaagagca cccaagcctc tttaatcatg aggagaaccc ccaattcctt    13440

tttttttgag acagagtctt gctcagtcgc ccaggctgga gtgcagtggc atgacttcgg    13500

ctcaccacaa cctctgcctc ccgggttcaa gtggttctcc ttcctcagcc tccctatagt    13560

ccctgattcc ttctattttt tttttttttt tttgagacgg agtctcgctc ttgttgccca    13620

ggctggagtg caatggtgca atctcaggtc atggcaacct tcacttccca ggttcaagca    13680

attctcctgc ctcagcctct cgagtagctg ggattacagg catgcgcctc cacgcctggc    13740

taattttgtt atttttagta gagacagggt ttctccatgt tggtcaggct ggtctcgaac    13800

tcacgacctc aggtgatcca cccacttcgg cctcccaaag tgctgggatt acaggcgtga    13860

gccaccacgt ctggcttctt tttctttttt tcccccgaga cggagtcttg ctctgttgcc    13920

caggctggag tgcagtggcg cgatctcagc tcactgcaac ctccgtctcc caggttcaag    13980

caattcttct gcctcagcct cctgagtagc tgggattaca ggtgcttgcc agcacgcctg    14040

gctaattttt gtatttttag tagagacggg gtttcactat gttggccagg ctggtcttga    14100

actcctgacc tcctaatcca cctgccttgg cctccccaaa tcctgggatt acaggcatga    14160

gccatcgtgc ccagcccctg attccttctt tttttttctt tctttttttt tttagacgga    14220

gtctcgctct gtcgcccagg ctggagtgca gtggcgcgat cttggcttac tgcaagctcc    14280

gcctcccggg ttcacgccat tctcctgcct cagcctcctg agtagctggg actacagggg    14340

cccgccacca tgcccggcta ataataatgt tgtattttta gtagagatgg ggtttcactg    14400

tgttagccag ggtggtctcg atctgacctc gtgatctgcc tgccttggcc tcccaaagtg    14460

ctgagattac aggcatgagc cactgtgccc agccctgatt ccttcttgat atcactacat    14520

ctttgtcctc tagggacctc ggaccgtccc ccagacccac tggagccacc gtcacttcct    14580

gctgagaggc cagggccccc cacacctgct gcggcccaca gcatccccta caacagctgc    14640

agagagaagg agccaagtta ccccatgcct gtccaggaga cccaggcgcc agagtcccca    14700

ggagaggtct gtcctcatag tctaccttga gccaccactt ttgtgttcct atctgcccac    14760

ttctgcccat tgagccttcc agaaaccctc tcccgtcccc tataaatcac gcctaatctc    14820

tgctcagaac cctagggctt cctcagtggg gatctgcccc agaccagctt ccaggctgct    14880

gaccaggtct tcaccctgtg gcagccctaa tcctctgtca gcaaccagct gggagaccac    14940

agttttgtgt gtgtgtgtgt gtgtgtgtgt gacagtgtct cattctgtca cccaggctgg    15000

agtgcagtgg agtgatcttg gctcactgca acctctgcct cctgggttca ggtcattctc    15060

ctgcctcagc ctcctgagta gctgggatta caggcaccca ccaccacgcc cagctaattt    15120

ttgtattttt agtagagatg gggttttgcc gtgtcagcca ggctggtctc gaactcctga    15180

cctcaggtga tctgcccacc tttgcctccc aaagtgctgg gattacaggc gtgagccacc    15240

gcacctggca atgctgtgtg ttttctgtga ggtagacgta aggacacctg tggacagagg    15300

gtctgggaat taccagaacc caggcaaggg ctcccctggc tcctgtgctc catggtgtgg    15360

gctgaggcct ataggagatg ccccaagagc acaagctgcc ctttgtgagc tcttgggaga    15420

ggcaactgcc ttattcatat tttccctcat tgcagaattc agagcaagcc ctgcagacgc    15480

tcagccccag agccatccca aggaatccag atggtggccc cctggagtcc tcctctgacc    15540

tggcagccct cagccctctg acctccagcg ggcatcagga gcaggacaca gaactgggca    15600

gtacccacac agcaggtatg catggaatct ggaattatag ggtccttctg atctctcaag    15660

tgagggtaag aattagagtt gccccatctg gcttccttga acaggagaca aggtgggaat    15720

aaagggagtt caacccagga agcaaaccag ttccttagtg ggtgtatcag ttagcatttg    15780

ctgtgtaaca aatagtccac tccagttttc caaatttttt ttttagtagc ttaaaataca    15840

gccatttatt tagcatatga tcctgtgggt caggcatttg ggctacctac atgggcattt    15900

cttctggtct tggctgaatt tcctctcaag tactcaccgg tatatacata agttctgcct    15960

ctggctgttt gctgagcacc ttggttctct tctatgtagt ctctcatcct ccagcacaca    16020

aacccatcat ggcagctggg cagagttctc agagagggct caaaactggc acagtgtccc    16080

ctgtgctcca ttctgtgggc aaaagcaagt tataaggcca gcctagattc aaggagtagg    16140

gaaatagact ccctccctag acgggaggac tgacaggcac agtgcagtgg ggctgggtgg    16200

agatgagcga gataagtagg gccatttttg cgctctgcca aagggactgt agggaacagc    16260

cagggcctat agggcagtgg gagagggaca gtgaagggct gcatcagctg ttggcagggg    16320

aacctttagg cactgtctta ccgcagagat ctccagttcc cagtgaatca tgaaaacttc    16380

tcagtcccca gaggaagtaa ggtcttcatc atccagtggc ctggactcaa ctccagatgt    16440

cagtgctccc cctcagaaat atatagttgt ccatctggac ctctcaggcc agcatgtctc    16500

tttcctactt cccaaactat tccacatgac gctggtgccc agtcagccct cagtgccctg    16560

ggacagccac aagacacatg agcagttaga ggctgggaga cgtcatctta gtacttttgt    16620

catccccaaa ctgctccaag cacctgtctg ctttgcagtg tcacctggcc acgggatgcc    16680

tttcaggagt tgctgtagac cacagaggca gagggcgctt aggtttcagt acgtttgtag    16740

acacaggtcc catgagattc tgtggtatta gattgtggtg ggggagctgt acatcagaat    16800

caccctgact tttgccagct gtggggcttg gcatgtgcat tccgagttcc gtggagagtc    16860

ctgctgcaac tgcctttaca gaccatcacc acctgctatc ctctgcttcc cccacccagg    16920

tcaggcagcc tcccaggggt ggctttgtcc ttgtcccctc tcttcccaag cctccgggat    16980

ggccaggcct ctcggctggt gtgagctgtt ctgcatgagc catcctgcca ccccttgccc    17040

tgatccatgg ctgctcccac tcatggtggt aggagaggga cagcagtggg ggaagtgtcc    17100

aggattgcat gaggctaagg tcaaagtaga aaaggtagac acaggagagg ggaggtttcc    17160

caggtgggag aggaaaaagc ggagagaata attaataatg gtcttcaggc tcctaggtac    17220

catttcactg tgtgccagga cagacctggg gctacaggtc aaggactgag ggcagctgtt    17280

gggctttcag gccaggaagc agtgaccaaa gggactgtgg catctcctcc aagggcagga    17340

gatttggagg cctagacaca gtagggacca tgagatctgg gccagaggga cccttctcca    17400

ggcctcaagg taatggtctt tgggtctgtg tttccacttg tgtttttcca ccggcaggtg    17460

cgacctccag cctcacacca tcccgtgggc ctgtgtctcc atctgtctcc ttccagcccc    17520

tggcccgttc cacccccagg gcaagccgct tgcctggacc cacagggtca gttgtatcta    17580

ctggcacctc cttctcctcc tcatcccctg gcttggcctc tgcaggggct gcagagggta    17640

aacagggtgc agagagtgac caggccgagc ctatcatctg ctccagtggg gcagaggcac    17700

ctgccaactc tctgccctcc aaagtgccta ccaccttgat gcctgtgaac acagtggccc    17760

tgaaagtgcc tgccaaccca gcatctgtca gcacagtgcc ctccaagttg ccaactagct    17820

caaagccccc tggtgcagtg ccttctaatg cgctcaccaa tccagcacca tccaaattgc    17880

ccatcaactc aacccgtgct ggcatggtgc catccaaagt gcctactagc atggtgctca    17940

ccaaggtgtc tgccagcaca gtccccactg acgggagcag cagaaatgag gtgagtcctc    18000

gcccttcctg gcagggatcc tggccccttc ccccgggaca gcttgcccac ctggccctgg    18060

ccttggcccc ttcccagtct gcattctgtg tccagcctgt gctgctctgt ggcctctcct    18120

tgagggcata cagacagttg agaaccagcc tcatgcaggc cccacaccat gttctccagg    18180

aggaacagtc attgagcttc taagtctgga cacctcagga gggtcagcca cagggggcac    18240

ccactggtca ggtgtataag ttcatttagg gctcgtagtt cctagtgaag ccgagcggtg    18300

ccgttttgca cataaggaag cagtgacggg gacagcacag tggcccatct gcctcttgcc    18360

ttgctcttca ccaggatgcc tggtgtgtcc ctccatggcc aggctttaca gaacgcagtc    18420

ccacctggag cagccactcg gacccagcag ccccccattg ttgcctgctc caagcctcac    18480

atctaaccct agctgcggct gtctgctggg aagagccaag tccatagggc cctttgggca    18540

catggccagg cctctgaccc tgtggctgct ctctagttct caggcccagg caggatgtca    18600

gtgcaggatg gagccccgcc ctaccaaagg cttccaggtg ggcatgagct cacaggcagg    18660

ccagggagta gggaaaggct gccctggagg aggccaccat tggtgcagat tcttggtccc    18720

ctctaccccc actgctccaa gaaaaggtgg cctaggggca ttatagattg ggaattgagg    18780

ggttggagtg ttagttcatg ccctggcctg ggaatgggac cgccctacca ggttcgtctc    18840

cctgccaacc ccagtccctt ccagtgctct cctttctttc ccaggagacc ccagcagctc    18900

caacacccgc cggcgccact ggaggcagct cagcctggct agacagcagc tctgagaata    18960

ggggccttgg gtcggagctg agtaagcctg gcgtgctggc atcccaggta gacagcccgt    19020

tctcgggctg cttcgaggat cttgccatca gtgccagcac ctccttgggc atggggccct    19080

gccatggccc agaggagaat gagtataagt ccgagggcac ctttgggatc cacgtggctg    19140

agaaccccag catccagctc ctggagggca accctgggcc acctgcggac ccggatggcg    19200

gccccaggcc acaagccgac cggaagttcc aggagaggga ggtgccatgc cacaggccct    19260

cacctggggc tctgtggctc caggtggctg tgacaggggt gctggtagtc acactcctgg    19320

tggtgctgta ccggcggcgt ctgcactagt gaagccctgg gctcttccca ccacccatct    19380

gttccgttcc tgcagtacac ctggcccctc tccgaagccc cttgtccctt tcttggggat    19440

tgtggaggct gggtcagagg ggagttaagg gactgcaggc ctggcagcag gacatgcctt    19500

ggctgaacca agtcctgaga gcagcatctc tgtccccacg gtgccttgtg tgggtccccg    19560

tccttggctt tctgggtcct gggctgcccc cagtgctcca gaccttcccc actggcaatc    19620

caggttatca tccatgtcct ccagaggagc ttcctcctcc aggcctcagc cctgttggcc    19680

caggtggagc aggagggacc actggaacat gtggtgcttg ggaatgcctc tcctgttgca    19740

ttggtccctg aaggcctcag ggcaggtatg tggtgtgtgg gcgactccac aagacctgcc    19800

tcccatcctg gcagcccagc ctgagaccgt tgcattgagg caggcaggag cggcagggtg    19860

gctgctctcc aggagcccaa ctgccttgag ttcctgcccc actgggcccc ctcccctgct    19920

gggcaatcct gggaaggtct ggaggttcct gtggacctca gggaagccag gggcagctgt    19980

caggcctgag gaagacctgt ggagctcctc tccagcctcc tctttccctc ccctctggtc    20040

tccattctct tcagctccct acatgggctg gggaggagac acctggtggg cagagctcag    20100

gcagaggttt ggatttcagc tccctcactt ccggggctgt gtggctttgg cagatgtcag    20160

acttctggtc ttgcttctcc acgtggacag tgagtatctg gctcattctt cactgggttc    20220

ttctgagatt gaacctacag gtgtttgcca agtgcctggc ccagagcaag tggccactgc    20280

ttctcccatc tctctcctgc ccaacctggt agagctgagg gcatgagagg cagagtgcac    20340

agtggtcaag ggtgcagctc tgcagcacag gcagcctagg cctgcgtccc aacctgcctc    20400

tcaccagctc tgtgaccttg ggcaagggat ttatctgtct gtcccttagt tttctcacct    20460

gtaaaaggag gataagtata tatatatatt tcccagtgtt gtgaagatta aaggagttta    20520

tcgatgtagg tcttaggatg agtcctggca tttaccaagg gttggatata tgttattatc    20580

actattaagt gttgagggtc caggcatgct gggcaacagg gaccccatct ctacaaaaaa    20640

gtttaaaaaa ttagccaggc gtggtggtgc acctgtcgtc ttagctactt gggaggctga    20700

ggtgggagga tcacttgagc ccagaagctt gaagctgcag tgagctagga tcgtgccact    20760

gcactccaac ctgggtgaga gagcgagacc ctgtctcaag aaaaagaaaa atgcagagaa    20820

acaggagtct tggctactcc tttagaggca gactcagacc ctcctgcctc acagctttat    20880

ctttgtattt gccccttact ttatcttgtg ccttgagaaa ttgctgggga gagaggtatg    20940

tccactgggc agctgtacag gatggaggat atagggcgtt tccactccca gcagccaggt    21000

tccctcaccc caagctcacc cactgttggg gagattatct acaataacac cagaaacaca    21060

ttggggtgga ttgggggtat ccttatgggt tcttttcagg gaaccattgc tggacaaggc    21120

acaggagcca cctccatttc tgagctctgc aagggacaag aactagagcc atcaggggct    21180

gggctcactg tggccccacc ccaagccgtc agcctccagg gatctacacc ctgccttggc    21240

tgctacagct ttttcactcc actgccctag gggagttcag caacctaatg atctctatct    21300

ctgaacatct cttcatccca tgctccaagt ccagcaacct gcaccctgga accaggagtg    21360

gaccctaccc gagctgtctg tattaatccc catcccccac caccaatctt aaaaagccct    21420

ctgtccccct accctaaacc ccagttaggt acccatgctg ggcaggtcag ttaacaattt    21480

atgcacaggt actagtttta ttgtattacc gttccagggt agctttgaaa aaagtatctc    21540

aaaaaggcaa catgggccga gcgcagtggc tcacgcctgt aatcccagca ctttgggagg    21600

ccaaggtggg cagatcgcct gaggtctgga gttcaagacc agcctggcca acagggtgaa    21660

accccgtctc tacaaaaata agaaaattag ccaggtgtag tggcagacgt ctgtaatccc    21720

agctattcag gaggctgagg cacgagaatt ccatgaaccc aggatgcgga ggttgcagtg    21780

agccgagatt gtgccactgc gctccagcct gggcgacaga gtggtattct gtttcaaaaa    21840

aaaaaaaaaa ggcagtatgt agccccgaag actgttgccc aagtggtaga atgttagcac    21900

actaccagcc taggtaaaaa atacaaaaag taactgggca tggcggcgcc catctatagt    21960

cccagctaca tgggaggctg aggtgggaag ataagtcact tgagcccgcc aggaggcgga    22020

ggttgtagtg agctgagatc gcaccactgc actccagcct gggtgaccga gtgatactct    22080

gtctcaaaga aaaaaaatta taattttagc acagtaacca gccatgatgg gagataccct    22140

gggtaaggca tgtagaaagg gttgagggac cttcccagtc ccctagcccc gcctcccatc    22200

ctcccatctt tttctttttt ctttttttta gagaatcacc cagcctggag cgaagtggtg    22260

caatcataac tcactgtatc cttaaactcc cgggcttaag cgatcctcct gcctcagcct    22320

tctgagtaac taggacttca ggtacctgtc accatgcctg gctaattaaa tttttttttc    22380

tttttttttt ttgagatgga gtcttgctct gtcacccagg ctggagtgca gtggcgcgat    22440

ctcagctcac tgcgacctcc acctcctggg ttcaggccat tctcccgcct cagcctccag    22500

agtagctggg actacaggcg cctgccacca cgcctggcta atttttttgc acttttagta    22560

gagacggggt ttcactgtgt tagccaggat ggtctcgatc tcctgacctt gtgatccgcc    22620

cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc caccgcgccc agccaaatta    22680

aattttttat agagatgagg tcatgctgtt atgttgccca ggttggcctc atgagatctt    22740

gccttagcct cccaaagtgc tgggattaca gatgtgagac actgcaccca aaccccacca    22800

cttttttttt tcctttttct ttttttgaga cagtcttact ccgttgccca ggctggagtg    22860

tagtggcatg atctcagctc actgcaacct ccgcctcccg ggttcaagca attctcctgc    22920

ctcagcctcc cgagtagctg ggattacaga ggcctgccac cacacccgac taattttcgt    22980

atttttagta gagacggggt ttctccatgt tggccaggct gttcttgaac tcctgacctc    23040

aagtgctcca cctgcgttgg cttcccaaag tgctgggata caggagtgag ccactgcgcc    23100

tggctgatcc cagcactttt caaatgatgc cgctcaaagc cgtgacttgg cctactttga    23160

acagcaaact tgttgctgct gttgtcaacc tgaaggcctc tcaaatgcca gcttcaagca    23220

gggtgtgaat tggccagtgt cagatctcag gagtcctgtg ttgagagtgt ggctttcagc    23280

tgcggggagc tgcacttggt ggggaaagcc aggcaggtca ccctcacagc cagataatgt    23340

ggaggtcaga acccaaggaa gggagtgaga cctccactcc cagtggggga cctggccacc    23400

catccttggg gacctgagaa agcgtacttc accttggggt gaaggctggg tggggccaga    23460

gggaccagtg ccctcctcag tgcttagggg cagagccacc tgcagcaatg gtatctgcat    23520

attagcccct ctccaccttc tttctcccgc tgaatcattt ccctcaaagc ccaagagctg    23580

tcactgcttc tttctccctg ggaagaatgc gtggactctg cctggtgata gactgaagcc    23640

agaacagtgc cacaccctcg ccttaattcc ttgctaggtg ttctcagatt tatgagactt    23700

cttagtcaaa tatgagggag gttggatgtg gtggcttgtg cctgtaatcc cagcattttg    23760

ggaagccgag gtgggaggat cccttgaagc caggagtttg agacaagcct gggcaacaaa    23820

gcaagaccct atctctaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaatc    23880

taggagatgc tctttaccct gcctggcctc aaactattaa tagcttcctt tgagcaacat    23940

tatttattat gaactttcaa acacaaaaaa gtagagagag tagaataaca aatccccatg    24000

agcccatcac ccaacttcag taattatcaa ttcatggcca tcttgttcac ccctgcctgc    24060

ttccctgctt cccctcattc tgcagaggtt cttttctttt gagacagagt gttgctctgt    24120

tgcccaggct ggagtgcagt ggtgcaactt cggctcactg caacctccgc ctcccaggtt    24180

caagtgattc tcctgcttca gcctctcaag tagctgggat tacagatgcc cgccaccaca    24240

cctggctaat tttcgtattt ttgttagaga tggggtttca ccatgttggc caggctggtc    24300

tcgaactcct gacctcaagt gatccgcccg ccttggcctc ccaaaatgct gggattacag    24360

gtgtgaacca cggtgcctgg ccactgtaca ggttatttat agaagttgga gagtgaaggg    24420

ttgagaaagc caaggggcag atgcgggtct ggaggatttt gtgcctaagg ccctctcttt    24480

gctcccagac agcatgaagt aacaatgagg catccacctc ttggttttgt ggcctctgtg    24540

gatgacgtct ctcaccttga accagttcag agttggagta gcgcaggatc ctgtcttcag    24600

aggaggggcc gaagcgggtt cctctgttgt caagctcttt ggaggtgcct ggctgctact    24660

actgtcccag agaggtgatg atgaatgatg ggtgtgtcca gtggcagttt gccccactga    24720

ggcaggggct tccactaggc cctgacagag cccttccagc aggcagaaat ccctgtgcta    24780

ggcaagattc aaactccgta gcatgtctcc tgctcccatc tcttaggaat ggagtccttc    24840

aggccttgag tcccacattt tccatgatgc tccattaagc agctgatagc acccccacct    24900

ccagggaaag tgagttcaga gtccttggtc taatgcatct gtgttgaaat tgaggccttc    24960

ccctgtgttc acctttctgc tctttttctt ttagcccaag gctatgaagg cctcattcgg    25020

tgctgggcat ggtcactcct agcattcctc actctgttgc taacagcaac agcaataata    25080

ataagggtta caacttactc cataccttac tgtctgccag gcattaagct aagtgcttta    25140

catatattaa gtcatttaat cctcataatg accctatgaa agagatacca tctcaaccca    25200

attgacagct ggtttgcaag attaggaggg atgaaggacc caggggacaa tgcgagggaa    25260

aactctgacc ccggggcccc aggctggatg ttctttatgc ctgtgaacca cagcttatca    25320

catgtctgga gttagggacc ccacttaaag tgagattttg gctggaggtg gtggatcata    25380

cctataatcc cagcactttg ggagaccaag gcagaaggac tgcttgaggc caggagttca    25440

aaaccagtgt aggtaacagc tagaccctat ctctacaaaa aatttaaaaa ttagctgggt    25500

gtggtggtat gtgcctcaag ttccagctac tcaggaggct gaggtgggag gatcacttga    25560

gcacaggagt ttgaagttac agtgagctat gatggcacca ctgcacttca gcctaggcaa    25620

cagagggaga ccctgtcttt aaagtacata gaggtttttc acaccaacac atctctgccc    25680

agtgtgccaa catctgccac ctgctataat agtactataa cactcaatat gtaattaatg    25740

tagtctcagg gatgttatga caatatgatt acaactatca cgtgtgtgcc cagccaggct    25800

caatgcccca ggctgggcga ggtggggcag gggacacagc ctaaaatgcc aggcctcagg    25860

aagccatttg gtttagcaga cattgtttat taaaggagtt acctatgcca gatcgaaggc    25920

ctaagatgat taagacacta tgagtgcctt caagtggttg gggacgttca tgattgtggt    25980

acagacaaat aggctttcac atcattcttt tatgtaatca tacaacagat atttgcacct    26040

acatgtgcag agcactgtga taggcctcag tgacacagaa taatacggca aagaccccac    26100

ccgatgagcc ccctcccacc acccaccagt acagtagggg gtggtttaat ggagtgttcc    26160

tggaatatga agtgggggca ggcattaggg gtggcaaagg gacaagtgtt tatctgatca    26220

gttatgtact gtttataata agtaaatcag cagaggggga ataatactta gaacctatag    26280

agagtaaatc tgacaagatg aaatgctgat gaaaatatgg aggaaatgaa actctcatgg    26340

gttttgcagg gaatctaagt cagtgctgtg ttgtgaatgt aggtgtaccc tttgaattca    26400

tatgttgaat cctaaccccc aaagcaatgg cattaagagg tggggccttt ggggctgggt    26460

atggtggctc atgactgtaa tcccagcact ttgggatgct ggcagggggc agatcacttg    26520

aagccaggag tctgagatca gcctggccaa catggtgaaa ccccatctgt actaaaaata    26580

caaaaattag ccaggtgtga tggcgtacat ctgtaatttc agccactcgg gaggctgaga    26640

caggagaata gcttgaaccc agtaggtgga gatttcagtg agccgagatc gtgccactgc    26700

actccagcct gggtgacaga gcgagactcc atctcaaaaa aataataaag atgtggggcc    26760

tgtgggaggt ggttaggtca tgagggtgga gatcatgaat ggggttagca ccttataaaa    26820

caggcttgag ggagcccttc tgtcccttct accatgtgtg gatgcagtga gaaggcaccg    26880

tatctctgaa gcagagagcc cgccctggac actggatctg ctggcacctt gatcttggac    26940

ttcccagcct ctagaactgt gagaaataat tttttgttgt ttacaaatta cccaggctaa    27000

ggtgtttcat tgtaacctga atggaccaag ctggtgtgac cctgttggaa aactggcagt    27060

atctaccaaa agccgaacat acgtataaac tgatccagca gttccactcc tgggtatgta    27120

caccacagaa agctatgtcc accgagacat tggcaagaat gtttctaacc acacgctgac    27180

tgtagcccca aacctgaaac aacccaaatg tccatccacc aacccaaatg tccatccaca    27240

gttgaagcta cagtgaagtc acagggtcga atactactgc acagcaacga atatgaatga    27300

aaatatcgct atgcacagca acatggataa atttcacaga catgaggtca agcaaaagag    27360

gtcagagtcc tcatcatcaa gagagaattc attgtatgat tctcttccta caaaaagtac    27420

agaaataagc aaaactgatc catggtgtta gaagccaggg gaacagttaa caggggaggg    27480

atactgggga ggggcatcct ggagtgctgg tctacctcat ctgggtgttg atttcacgag    27540

tattgtcagt ttgtttccag actccctgtt ggagatgtgg aaataaaaac cacctaaaca    27600

agagcagaga ggccatttgg tcaaagtttg caaaggagtc agccatgatt gcttgtattt    27660

ggcaggggtc aaaggcaggc agggactgtg aaatgttata gtggaaaaaa agggaaggct    27720

ctgggtgtgc tgtgattgga gattgttggc atggggacag agcggactaa ctggaggggc    27780

atctttggtt ggttgggggg gtatatttgg ctttctctgg ttggtctgga gttggaagag    27840

ggggtgtggt ggctggggat tgggaagaag ctggcagcca ctaagttcag actgttctgg    27900

gtccgattgc tgctgaggct gtggtttggc ttccttggct tcccaggctg gtcatgggtt    27960

tctggccaga gtctattgtc atatgtggcc tggccattgt ccagttgtat gttcagtctc    28020

ttggaaggaa gggtattgac tctgagaggg gccaccatcg ctggaatggg ggacacacag    28080

tacttcctcc agctgcctac acccccctag ggtcagtggc gcctgcctgt gagggtgagc    28140

ccaatggcta gagggctctg ctccaagtca ttgcttacta cacccacaaa cattcttcgt    28200

tctttaaggc ctaacttaaa gcccagatcc tacaggaaac cttgattaga cccctctctt    28260

tattaagctt cctaagatca aaccctgctt ttgtgtaaat gctgacctcc ttgcctacat    28320

tttaaaaacc tagagctggg catgatggcc ccagcctgta atcccagtga ttcaggagac    28380

tgaggtggga ggattgctag aagccaggag ttcgagacca gcctgggtaa catagctaga    28440

ccacatctct taaaataaaa tagttaattt agccaggcat gatgatatat gcctgtagtc    28500

ccaactactt ggaaggctga ggtgtgagga tctttgagcc cgggaggtcg aggctacagt    28560

aagctatgat ctcaccactg tactccagcc tgggtgacag agcgagaccc agactcaaaa    28620

aataaaaata aaaaccctga atatcttcct tctacttctt cagtgctgtt tttatttaaa    28680

aaaaaaaaaa accagccaaa accacaactt tttactgaag tgtaatgtaa atgctgtaaa    28740

aggcagtgaa aggcacaagg gaggtggagg ggtaggaagg gtggaagtgg cgggaggaag    28800

tggcagggca ggcaaaatga agggaagccc tgggttcttg tcctgcatcc gcagccagct    28860

cccactttcc tcaccctcca ggacctgtaa actgtgaggc tggaccagtt atgtcaaatc    28920

tgtcctcccc cagagctcag tccctctgcc cttgggtgtc cttggcacaa ggcaggctag    28980

gctgcaccag cttcctccat ctccgtcctg cctcccccat ccccaggtgc cattcccaca    29040

ccatctgaat cactgatttc ctcgcaatca gacgctatct tccagttaat cacttcgctt    29100

gtatttaaca taagaaagaa aaaccctttc attatcacat acagctggaa atcggcttct    29160

tgcaggaggc gtatccaaag gaattggaga agagataaac tggtaattgg tgaaagaatt    29220

actttaattt tttttcctac ttgctgtcat gatgatgtcc ttagaattgt gagcccgtgg    29280

acacttctgt acaataaatc tgctattatt acttctagaa ctaca                    29325


<210> 6
<211> 379
<212> PRT
<213> Homo sapiens

<400> 6
Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Gly Asp His Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asp Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala Asp Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala Val Pro 
            340                 345                 350         


Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Lys Pro Leu Pro Leu Arg Thr Asp Phe Ser 
    370                 375                 


<210> 7
<211> 2223
<212> DNA
<213> Homo sapiens

<400> 7
tataaaaata gctcttgtta ccggaaataa ctgttcattt ttcactcctc cctcctaggt       60

cacacttttc agaaaaagaa tctgcatcct ggaaaccaga agaaaaatat gagacgggga      120

atcatcgtgt gatgtgtgtg ctgcctttgg ctgagtgtgt ggagtcctgc tcaggtgtta      180

ggtacagtgt gtttgatcgt ggtggcttga ggggaacccg ctgttcagag ctgtgactgc      240

ggctgcactc agagaagctg cccttggctg ctcgtagcgc cgggccttct ctcctcgtca      300

tcatccagag cagccagtgt ccgggaggca gaagatgccc cactccagcc tgcatccatc      360

catcccgtgt cccaggggtc acggggccca gaaggcagcc ttggttctgc tgagtgcctg      420

cctggtgacc ctttgggggc taggagagcc accagagcac actctccggt acctggtgct      480

ccacctagcc tccctgcagc tgggactgct gttaaacggg gtctgcagcc tggctgagga      540

gctgcgccac atccactcca ggtaccgggg cagctactgg aggactgtgc gggcctgcct      600

gggctgcccc ctccgccgtg gggccctgtt gctgctgtcc atctatttct actactccct      660

cccaaatgcg gtcggcccgc ccttcacttg gatgcttgcc ctcctgggcc tctcgcaggc      720

actgaacatc ctcctgggcc tcaagggcct ggccccagct gagatctctg cagtgtgtga      780

aaaagggaat ttcaacgtgg cccatgggct ggcatggtca tattacatcg gatatctgcg      840

gctgatcctg ccagagctcc aggcccggat tcgaacttac aatcagcatt acaacaacct      900

gctacggggt gcagtgagcc agcggctgta tattctcctc ccattggact gtggggtgcc      960

tgataacctg agtatggctg accccaacat tcgcttcctg gataaactgc cccagcagac     1020

cggtgaccat gctggcatca aggatcgggt ttacagcaac agcatctatg agcttctgga     1080

gaacgggcag cgggcgggca cctgtgtcct ggagtacgcc acccccttgc agactttgtt     1140

tgccatgtca caatacagtc aagctggctt tagccgggag gataggcttg agcaggccaa     1200

actcttctgc cggacacttg aggacatcct ggcagatgcc cctgagtctc agaacaactg     1260

ccgcctcatt gcctaccagg aacctgcaga tgacagcagc ttctcgctgt cccaggaggt     1320

tctccggcac ctgcggcagg aggaaaagga agaggttact gtgggcagct tgaagacctc     1380

agcggtgccc agtacctcca cgatgtccca agagcctgag ctcctcatca gtggaatgga     1440

aaagcccctc cctctccgca cggatttctc ttgagaccca gggtcaccag gccagagcct     1500

ccagtggtct ccaagcctct ggactggggg ctctcttcag tggctgaatg tccagcagag     1560

ctatttcctt ccacaggggg ccttgcaggg aagggtccag gacttgacat cttaagatgc     1620

gtcttgtccc cttgggccag tcatttcccc tctctgagcc tcggtgtctt caacctgtga     1680

aatgggatca taatcactgc cttacctccc tcacggttgt tgtgaggact gagtgtgtgg     1740

aagtttttca taaactttgg atgctagtgt acttaggggg tgtgccaggt gtctttcatg     1800

gggccttcca gacccactcc ccacccttct ccccttcctt tgcccgggga cgccgaactc     1860

tctcaatggt atcaacaggc tccttcgccc tctggctcct ggtcatgttc cattattggg     1920

gagccccagc agaagaatgg agaggaggag gaggctgagt ttggggtatt gaatcccccg     1980

gctcccaccc tgcagcatca aggttgctat ggactctcct gccgggcaac tcttgcgtaa     2040

tcatgactat ctctaggatt ctggcaccac ttccttccct ggccccttaa gcctagctgt     2100

gtatcggcac ccccacccca ctagagtact ccctctcact tgcggtttcc ttatactcca     2160

cccctttctc aacggtcctt ttttaaagca catctcagat tacccaaaaa aaaaaaaaaa     2220

aaa                                                                   2223


<210> 8
<211> 712
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Cys Thr Gly Pro Ser Leu Pro Ser Ala Phe Asp Ile Leu Gly 
1               5                   10                  15      


Ala Ala Gly Gln Asp Lys Leu Leu Tyr Leu Lys His Lys Leu Lys Thr 
            20                  25                  30          


Pro Arg Pro Gly Cys Gln Gly Gln Asp Leu Leu His Ala Met Val Leu 
        35                  40                  45              


Leu Lys Leu Gly Gln Glu Thr Glu Ala Arg Ile Ser Leu Glu Ala Leu 
    50                  55                  60                  


Lys Ala Asp Ala Val Ala Arg Leu Val Ala Arg Gln Trp Ala Gly Val 
65                  70                  75                  80  


Asp Ser Thr Glu Asp Pro Glu Glu Pro Pro Asp Val Ser Trp Ala Val 
                85                  90                  95      


Ala Arg Leu Tyr His Leu Leu Ala Glu Glu Lys Leu Cys Pro Ala Ser 
            100                 105                 110         


Leu Arg Asp Val Ala Tyr Gln Glu Ala Val Arg Thr Leu Ser Ser Arg 
        115                 120                 125             


Asp Asp His Arg Leu Gly Glu Leu Gln Asp Glu Ala Arg Asn Arg Cys 
    130                 135                 140                 


Gly Trp Asp Ile Ala Gly Asp Pro Gly Ser Ile Arg Thr Leu Gln Ser 
145                 150                 155                 160 


Asn Leu Gly Cys Leu Pro Pro Ser Ser Ala Leu Pro Ser Gly Thr Arg 
                165                 170                 175     


Ser Leu Pro Arg Pro Ile Asp Gly Val Ser Asp Trp Ser Gln Gly Cys 
            180                 185                 190         


Ser Leu Arg Ser Thr Gly Ser Pro Ala Ser Leu Ala Ser Asn Leu Glu 
        195                 200                 205             


Ile Ser Gln Ser Pro Thr Met Pro Phe Leu Ser Leu His Arg Ser Pro 
    210                 215                 220                 


His Gly Pro Ser Lys Leu Cys Asp Asp Pro Gln Ala Ser Leu Val Pro 
225                 230                 235                 240 


Glu Pro Val Pro Gly Gly Cys Gln Glu Pro Glu Glu Met Ser Trp Pro 
                245                 250                 255     


Pro Ser Gly Glu Ile Ala Ser Pro Pro Glu Leu Pro Ser Ser Pro Pro 
            260                 265                 270         


Pro Gly Leu Pro Glu Val Ala Pro Asp Ala Thr Ser Thr Gly Leu Pro 
        275                 280                 285             


Asp Thr Pro Ala Ala Pro Glu Thr Ser Thr Asn Tyr Pro Val Glu Cys 
    290                 295                 300                 


Thr Glu Gly Ser Ala Gly Pro Gln Ser Leu Pro Leu Pro Ile Leu Glu 
305                 310                 315                 320 


Pro Val Lys Asn Pro Cys Ser Val Lys Asp Gln Thr Pro Leu Gln Leu 
                325                 330                 335     


Ser Val Glu Asp Thr Thr Ser Pro Asn Thr Lys Pro Cys Pro Pro Thr 
            340                 345                 350         


Pro Thr Thr Pro Glu Thr Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser 
        355                 360                 365             


Ser Thr Pro Cys Ser Ala His Leu Thr Pro Ser Ser Leu Phe Pro Ser 
    370                 375                 380                 


Ser Leu Glu Ser Ser Ser Glu Gln Lys Phe Tyr Asn Phe Val Ile Leu 
385                 390                 395                 400 


His Ala Arg Ala Asp Glu His Ile Ala Leu Arg Val Arg Glu Lys Leu 
                405                 410                 415     


Glu Ala Leu Gly Val Pro Asp Gly Ala Thr Phe Cys Glu Asp Phe Gln 
            420                 425                 430         


Val Pro Gly Arg Gly Glu Leu Ser Cys Leu Gln Asp Ala Ile Asp His 
        435                 440                 445             


Ser Ala Phe Ile Ile Leu Leu Leu Thr Ser Asn Phe Asp Cys Arg Leu 
    450                 455                 460                 


Ser Leu His Gln Val Asn Gln Ala Met Met Ser Asn Leu Thr Arg Gln 
465                 470                 475                 480 


Gly Ser Pro Asp Cys Val Ile Pro Phe Leu Pro Leu Glu Ser Ser Pro 
                485                 490                 495     


Ala Gln Leu Ser Ser Asp Thr Ala Ser Leu Leu Ser Gly Leu Val Arg 
            500                 505                 510         


Leu Asp Glu His Ser Gln Ile Phe Ala Arg Lys Val Ala Asn Thr Phe 
        515                 520                 525             


Lys Pro His Arg Leu Gln Ala Arg Lys Ala Met Trp Arg Lys Glu Gln 
    530                 535                 540                 


Asp Thr Arg Ala Leu Arg Glu Gln Ser Gln His Leu Asp Gly Glu Arg 
545                 550                 555                 560 


Met Gln Ala Ala Ala Leu Asn Ala Ala Tyr Ser Ala Tyr Leu Gln Ser 
                565                 570                 575     


Tyr Leu Ser Tyr Gln Ala Gln Met Glu Gln Leu Gln Val Ala Phe Gly 
            580                 585                 590         


Ser His Met Ser Phe Gly Thr Gly Ala Pro Tyr Gly Ala Arg Met Pro 
        595                 600                 605             


Phe Gly Gly Gln Val Pro Leu Gly Ala Pro Pro Pro Phe Pro Thr Trp 
    610                 615                 620                 


Pro Gly Cys Pro Gln Pro Pro Pro Leu His Ala Trp Gln Ala Gly Thr 
625                 630                 635                 640 


Pro Pro Pro Pro Ser Pro Gln Pro Ala Ala Phe Pro Gln Ser Leu Pro 
                645                 650                 655     


Phe Pro Gln Ser Pro Ala Phe Pro Thr Ala Ser Pro Ala Pro Pro Gln 
            660                 665                 670         


Ser Pro Gly Leu Gln Pro Leu Ile Ile His His Ala Gln Met Val Gln 
        675                 680                 685             


Leu Gly Leu Asn Asn His Met Trp Asn Gln Arg Gly Ser Gln Ala Pro 
    690                 695                 700                 


Glu Asp Lys Thr Gln Glu Ala Glu 
705                 710         


<210> 9
<211> 2727
<212> DNA
<213> Homo sapiens

<400> 9
ttcccagggc gcgggccgcg gggtggagcc agcgccctca gcgcgctacg gtccgcgggc       60

aactccgcag aagccccagc ccccaggacc ccaggaccca gtggcgcagc cggcagcccc      120

ggatccctga tctgcttggg cagctcctgc agaacctgga acagtgaatg ggtaggggac      180

actgggcgtg cagaaggcgg ggggcagtgt ggaacatgcc ttcaccacct ccagcttctg      240

ctgccggagg ctgcacccac ctgtgcccat ggcctgcaca ggcccatcac ttcctagcgc      300

cttcgacatt ctaggtgcag caggccagga caagctcttg tatctgaagc acaaactgaa      360

gaccccacgc ccaggctgcc aggggcagga cctcctgcat gccatggttc tcctgaagct      420

gggccaggaa actgaggcca ggatctctct agaggcattg aaggccgatg cggtggcccg      480

gctggtggcc cgccagtggg ctggcgtgga cagcaccgag gacccagagg agcccccaga      540

tgtgtcctgg gctgtggccc gcttgtacca cctgctggct gaggagaagc tgtgccccgc      600

ctcgctgcgg gacgtggcct accaggaagc cgtccgcacc ctcagctcca gggacgacca      660

ccggctgggg gaacttcagg atgaggcccg aaaccggtgt gggtgggaca ttgctgggga      720

tccagggagc atccggacgc tccagtccaa tctgggctgc ctcccaccat cctcggcttt      780

gccctctggg accaggagcc tcccacgccc cattgacggt gtttcggact ggagccaagg      840

gtgctccctg cgatccactg gcagccctgc ctccctggcc agcaacttgg aaatcagcca      900

gtcccctacc atgcccttcc tcagcctgca ccgcagccca catgggccca gcaagctctg      960

tgacgacccc caggccagct tggtgcccga gcctgtcccc ggtggctgcc aggagcctga     1020

ggagatgagc tggccgccat cgggggagat tgccagccca ccagagctgc caagcagccc     1080

acctcctggg cttcccgaag tggccccaga tgcaacctcc actggcctcc ctgatacccc     1140

cgcagctcca gaaaccagca ccaactaccc agtggagtgc accgaggggt ctgcaggccc     1200

ccagtctctc cccttgccta ttctggagcc ggtcaaaaac ccctgctctg tcaaagacca     1260

gacgccactc caactttctg tagaagatac cacctctcca aataccaagc cgtgcccacc     1320

tactcccacc accccagaaa catcccctcc tcctcctcct cctcctcctt catctactcc     1380

ttgttcagct cacctgaccc cctcctccct gttcccttcc tccctggaat catcatcgga     1440

acagaaattc tataactttg tgatcctcca cgccagggca gacgaacaca tcgccctgcg     1500

ggttcgggag aagctggagg cccttggcgt gcccgacggg gccaccttct gcgaggattt     1560

ccaggtgccg gggcgcgggg agctgagctg cctgcaggac gccatagacc actcagcttt     1620

catcatccta cttctcacct ccaacttcga ctgtcgcctg agcctgcacc aggtgaacca     1680

agccatgatg agcaacctca cgcgacaggg gtcgccagac tgtgtcatcc ccttcctgcc     1740

cctggagagc tccccggccc agctcagctc cgacacggcc agcctgctct ccgggctggt     1800

gcggctggac gaacactccc agatcttcgc caggaaggtg gccaacacct tcaagcccca     1860

caggcttcag gcccgaaagg ccatgtggag gaaggaacag gacacccgag ccctgcggga     1920

acagagccaa cacctggacg gtgagcggat gcaggcggcg gcactgaacg cagcctactc     1980

agcctacctc cagagctact tgtcctacca ggcacagatg gagcagctcc aggtggcttt     2040

tgggagccac atgtcatttg ggactggggc gccctatggg gctcgaatgc cctttggggg     2100

ccaggtgccc ctgggagccc cgccaccctt tcccacttgg ccggggtgcc cgcagccgcc     2160

acccctgcac gcatggcagg ctggcacccc cccaccgccc tccccacagc cagcagcctt     2220

tccacagtca ctgcccttcc cgcagtcccc agccttccct acggcctcac ccgcaccccc     2280

tcagagccca gggctgcaac ccctcattat ccaccacgca cagatggtac agctggggct     2340

gaacaaccac atgtggaacc agagagggtc ccaggcgccc gaggacaaga cgcaggaggc     2400

agaatgaccg cgtgtccttg cctgaccacc tggggaacac ccctggaccc aggcatcggc     2460

caggacccca tagagcaccc cggtctgccc tgtgccctgt ggacagtgga agatgaggtc     2520

atctgccact ttcaggacat tgtccgggag cccttcattt aggacaaaac gggcgcgatg     2580

atgccctggc tttcagggtg gtcagaactg gatacggtgt ttacaattcc aatctctcta     2640

tttctgggtg aagggtcttg gtggtggggg tattgctacg gtcttttaat tataataaat     2700

atttattgaa tgcttccgca gcaaaaa                                         2727


<210> 10
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 10
His His His His His His 
1               5       


