                         SEQUENCE LISTING

<110>  Ganymed Pharmaceuticals GmbH et al.
 
<120>  Antibodies useful in cancer diagnosis

<130>  342-99 PCT2

<150>  PCT/EP2017/072386
<151>  2017-09-06

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 
1               5                   10                  15      


Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 
                85                  90                  95      


Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 
            100                 105                 110         


Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 
        115                 120                 125             


Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 
            180                 185                 190         


Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 
        195                 200                 205             


Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
    210                 215                 220 


<210>  2
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Thr Gly Leu Glu Leu Leu Gly Met Thr Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Gly Thr Leu Val Ser Cys Ala Leu Pro Leu Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Leu Ala Leu Leu Gly Leu Leu 
                85                  90                  95      


Val Ala Ile Thr Gly Ala Gln Cys Thr Thr Cys Val Glu Asp Glu Gly 
            100                 105                 110         


Ala Lys Ala Arg Ile Val Leu Thr Ala Gly Val Ile Leu Leu Leu Ala 
        115                 120                 125             


Gly Ile Leu Val Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Leu Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ala Ala Leu Leu Met Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Pro Pro Gln Val Glu Arg 
            180                 185                 190         


Pro Arg Gly Pro Arg Leu Gly Tyr Ser Ile Pro Ser Arg Ser Gly Ala 
        195                 200                 205             


Ser Gly Leu Asp Lys Arg Asp Tyr Val 
    210                 215         


<210>  3
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Met Gly Leu Glu Ile Thr Gly Thr Ala Leu Ala Val Leu Gly 
1               5                   10                  15      


Trp Leu Gly Thr Ile Val Cys Cys Ala Leu Pro Met Trp Arg Val Ser 
            20                  25                  30          


Ala Phe Ile Gly Ser Asn Ile Ile Thr Ser Gln Asn Ile Trp Glu Gly 
        35                  40                  45              


Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys Lys 
    50                  55                  60                  


Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala Arg 
65                  70                  75                  80  


Ala Leu Ile Val Val Ala Ile Leu Leu Ala Ala Phe Gly Leu Leu Val 
                85                  90                  95      


Ala Leu Val Gly Ala Gln Cys Thr Asn Cys Val Gln Asp Asp Thr Ala 
            100                 105                 110         


Lys Ala Lys Ile Thr Ile Val Ala Gly Val Leu Phe Leu Leu Ala Ala 
        115                 120                 125             


Leu Leu Thr Leu Val Pro Val Ser Trp Ser Ala Asn Thr Ile Ile Arg 
    130                 135                 140                 


Asp Phe Tyr Asn Pro Val Val Pro Glu Ala Gln Lys Arg Glu Met Gly 
145                 150                 155                 160 


Ala Gly Leu Tyr Val Gly Trp Ala Ala Ala Ala Leu Gln Leu Leu Gly 
                165                 170                 175     


Gly Ala Leu Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr 
            180                 185                 190         


Ala Thr Lys Val Val Tyr Ser Ala Pro Arg Ser Thr Gly Pro Gly Ala 
        195                 200                 205             


Ser Leu Gly Thr Gly Tyr Asp Arg Lys Asp Tyr Val 
    210                 215                 220 


<210>  4
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser Met Gly Leu Gln Val Met Gly Ile Ala Leu Ala Val Leu 
1               5                   10                  15      


Gly Trp Leu Ala Val Met Leu Cys Cys Ala Leu Pro Met Trp Arg Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Ser Asn Ile Val Thr Ser Gln Thr Ile Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Asn Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Val Ile Ile Ser Ile Ile Val Ala Ala Leu Gly Val Leu 
                85                  90                  95      


Leu Ser Val Val Gly Gly Lys Cys Thr Asn Cys Leu Glu Asp Glu Ser 
            100                 105                 110         


Ala Lys Ala Lys Thr Met Ile Val Ala Gly Val Val Phe Leu Leu Ala 
        115                 120                 125             


Gly Leu Met Val Ile Val Pro Val Ser Trp Thr Ala His Asn Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Ser Gly Gln Lys Arg Glu Met 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Val Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Asn Cys Pro Pro Arg Thr Asp Lys Pro 
            180                 185                 190         


Tyr Ser Ala Lys Tyr Ser Ala Ala Arg Ser Ala Ala Ala Ser Asn Tyr 
        195                 200                 205             


Val 
    


<210>  5
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Ser Thr Gly Leu Gln Ile Leu Gly Ile Val Leu Thr Leu Leu 
1               5                   10                  15      


Gly Trp Val Asn Ala Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Met Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Val Thr Leu Leu Ile Val Leu Leu Gly Leu Leu 
                85                  90                  95      


Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Asp Arg Asn 
            100                 105                 110         


Ser Lys Ser Arg Leu Val Leu Ile Ser Gly Ile Ile Phe Val Ile Ser 
        115                 120                 125             


Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ser Ile Ile 
    130                 135                 140                 


Gln Asp Phe Tyr Asn Pro Leu Val Ala Asp Ala Gln Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Ala Cys Ser Ser Gly Gly Thr Gln Gly 
            180                 185                 190         


Pro Arg His Tyr Met Ala Cys Tyr Ser Thr Ser Val Pro His Ser Arg 
        195                 200                 205             


Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
    210                 215                 


<210>  6
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  6

Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly Pro Ser His 
1               5                   10                  15      


Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro 
            20                  25                  30          


Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
        35                  40      


<210>  7
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  7

Leu Leu Cys Cys Ala Cys Ser Ser Gly Gly Thr Gln Gly Pro Arg His 
1               5                   10                  15      


Tyr Met Ala Cys Tyr Ser Thr Ser Val Pro His Ser Arg Gly Pro Ser 
            20                  25                  30          


Glu Tyr Pro Thr Lys Asn Tyr Val 
        35                  40  


<210>  8
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  8

Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly Pro Ser His Tyr Met Ala 
1               5                   10                  15      


Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu Tyr 
            20                  25                  30          


Pro Thr Lys Asn Tyr Val 
        35              


<210>  9
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  9

Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly Pro Ser His Tyr 
1               5                   10                  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  10

Pro Ser Gly Gly Ser Gln Gly Pro Ser His Tyr Met Ala Arg Tyr 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  11

Ser Gln Gly Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  12

Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  13

Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  14

Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu Tyr Pro Thr 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  15

Ala Ile Ser Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  16

Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  17

Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  18

Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu Tyr 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  19

Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu Tyr Pro 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  20

Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu Tyr Pro Thr Lys 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  21

Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  22

Pro Ala Ile Ser Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr 
1               5                   10                  15  


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  23

Ile Ser Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5                   10                  


<210>  24
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  24

Ser Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5                   10              


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  25

Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5                   10          


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  26

Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5                   10      


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  27

Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5                   10  


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  28

Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5                   


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  29

Glu Tyr Pro Thr Lys Asn Tyr Val 
1               5               


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  30

Tyr Pro Thr Lys Asn Tyr Val 
1               5           


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  31

Pro Thr Lys Asn Tyr Val 
1               5       


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  32

Pro Thr Lys Asn Tyr 
1               5   


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  33

Pro Thr Lys Asn 
1               


<210>  34
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  34

Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly Pro Ser His Tyr 
1               5                   10                  15      


Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser 
            20                  25                  30          


Glu Tyr Pro Thr Lys Asn Tyr Val 
        35                  40  


<210>  35
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  35

Leu Cys Cys Thr Cys Pro Pro Pro Gln Val Glu Arg Pro Arg Gly Pro 
1               5                   10                  15      


Arg Leu Gly Tyr Ser Ile Pro Ser Arg Ser Gly Ala Ser Gly Leu Asp 
            20                  25                  30          


Lys Arg Asp Tyr Val 
        35          


<210>  36
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  36

Leu Cys Cys Ser Cys Pro Pro Arg Glu Lys Lys Tyr Thr Ala Thr Lys 
1               5                   10                  15      


Val Val Tyr Ser Ala Pro Arg Ser Thr Gly Pro Gly Ala Ser Leu Gly 
            20                  25                  30          


Thr Gly Tyr Asp Arg Lys Asp Tyr Val 
        35                  40      


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  37

Leu Cys Cys Asn Cys Pro Pro Arg Thr Asp Lys Pro Tyr Ser Ala Lys 
1               5                   10                  15      


Tyr Ser Ala Ala Arg Ser Ala Ala Ala Ser Asn Tyr Val 
            20                  25                  


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  38

Glu Tyr Pro Thr Lys Asn Tyr 
1               5           


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  39

Arg Gly Pro Ser 
1               


<210>  40
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody chain

<400>  40

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Arg Thr Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Glu Arg Pro Gly Gln Gly Leu Val Trp Ile 
        35                  40                  45              


Gly Ala Ile Phe Pro Gly Asn Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Ser Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Asp Leu Ser Ser Leu Thr Asp Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Phe Tyr Ala Thr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  41
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody chain

<400>  41

Asp Ile Val Leu Thr Gln Asn Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Thr Ala Ser Ile Ser Cys Lys Ser Ser Gln Asn Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Met Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Asn Thr 
            100                 105                 110         


<210>  42
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody chain

<400>  42

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Arg Thr Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Glu Asn Ser Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ser Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Thr Asp Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Phe Tyr Ala Thr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody chain

<400>  43

Asp Val Val Met Thr Gln Asn Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Thr Ala Ser Ile Ser Cys Lys Ser Ser Gln Asn Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Met Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105                 110         


<210>  44
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody chain

<400>  44

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Arg Thr Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Glu Asn Ser Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ser Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Thr Asp Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Glu Phe Tyr Ala Thr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  45
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody chain

<400>  45

Asp Ile Val Leu Thr Gln Asn Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Thr Ala Ser Ile Ser Cys Lys Ser Ser Gln Asn Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Met Ser Lys Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Ser 
            100                 105                 110         


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  46

Cys Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu 
1               5                   10                  15      


Leu 
    


<210>  47
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  47

Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 
1               5                   10                  15      


Pro Ser His Tyr 
            20  


<210>  48
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  48

Cys Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser 
1               5                   10                  15      


Glu Tyr Pro Thr Lys 
            20      


<210>  49
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  49

Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly Pro Ser His Tyr Met 
1               5                   10                  15      


Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser Arg Gly Pro Ser Glu 
            20                  25                  30          


Tyr Pro Thr Lys Asn Tyr Val 
        35                  


<210>  50
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  50

Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp Ser Lys Ala Arg Leu 
1               5                   10                  15      


Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser Gly Val Leu Thr Leu 
            20                  25                  30          


Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile Arg Asp Phe Tyr Asn 
        35                  40                  45              


Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu Gly Ala 
    50                  55                  60      


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR

<400>  51

Gly Tyr Ile Phe Thr Thr Tyr Trp 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR

<400>  52

Ile Phe Pro Gly Asn Ser Asp Thr 
1               5               


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR

<400>  53

Thr Arg Glu Phe Tyr Ala Thr 
1               5           


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR

<400>  54

Gln Asn Leu Leu Tyr Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR

<400>  55

Leu Met Ser 
1           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain CDR

<400>  56

Trp Gln Gly Thr His Phe Pro Trp Thr 
1               5                   


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR

<400>  57

Gly Tyr Thr Phe Thr Thr Tyr Trp 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain CDR

<400>  58

Ile Tyr Pro Glu Asn Ser Asp Ala 
1               5               


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  59

Glu Tyr Pro Thr Lys 
1               5   


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  60

Glu Tyr Pro Thr Lys Asn 
1               5       


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide

<400>  61

Tyr Pro Thr Lys Asn Tyr 
1               5       


