                         SEQUENCE LISTING

<110>  IDP Discovery Pharma S.L.
       Fundacin de Investigacin del Cncer. Universidad de Salamanca.
 
<120>  NEW TREATMENTS OF MULTIPLE MYELOMA

<130>  903 501

<150>  EP 17 382 601.7
<151>  2017-09-08

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<223>  It corresponds to the peptidic sequence (without the birradical 
       ligand) of the compound S09

<400>  1

Ala Pro Lys Ala Val Ile Leu Lys Lys Ala Ala Ala Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<223>  It corresponds to the peptidic sequence (without the birradical 
       ligand) of the compound S14

<400>  2

Ala Pro Lys Ala Val Ile Phe Lys Lys Ala Ala Ala Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S09


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  The X residue at position 4 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 11 via a L birradical which
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  The X residue at position 11 has formula (II) where R1 is -CH3

<400>  3

Ala Pro Lys Xaa Val Ile Leu Lys Lys Ala Xaa Ala Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S14


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  The X residue at position 4 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 11 via a L birradical which
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  The X residue at position 11 has formula (II) where R1 is -CH3

<400>  4

Ala Pro Lys Xaa Val Ile Phe Lys Lys Ala Xaa Ala Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S19


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  The X residue at position 2 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 9 via a L birradical which 
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  The X residue at position 9 has formula (II) where R1 is -CH3

<400>  5

Ala Xaa Lys Val Val Ile Leu Lys Xaa Ala Thr Ala Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S21


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  The X residue at position 5 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 12 via a L birradical which
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  The X residue at position 12 has formula (II) where R1 is -CH3

<400>  6

Ala Pro Lys Val Xaa Ile Leu Lys Lys Ala Thr Xaa Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S22


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  The X residue at position 6 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 13 via a L birradical which
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  The X residue at position 13 has formula (II) where R1 is -CH3

<400>  7

Ala Pro Lys Val Val Xaa Leu Lys Lys Ala Thr Ala Xaa Ile Leu Ser 
1               5                   10                  15      


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S23


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  The X residue at position 9 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 16 via a L birradical which
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  The X residue at position 16 has formula (II) where R1 is -CH3

<400>  8

Ala Pro Lys Val Val Ile Leu Lys Xaa Ala Thr Ala Tyr Ile Leu Xaa 
1               5                   10                  15      


Val 
    


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S17


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  The X residue at position 7 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 14 via a L birradical which
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  The X residue at position 14 has formula (II) where R1 is -CH3

<400>  9

Ala Pro Lys Val Val Ile Xaa Lys Lys Ala Thr Ala Tyr Xaa Leu Ser 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound S18


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  The X residue at position 8 has formula (II) where R1 is -CH3 and
       it binds to the X residue at position 15 via a L birradical which
       is -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  The X residue at position 15 has formula (II) where R1 is -CH3

<400>  10

Ala Pro Lys Val Val Ile Leu Xaa Lys Ala Thr Ala Tyr Ile Xaa Ser 
1               5                   10                  15      


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<223>  wild type sequence

<400>  11

Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala Tyr Ile 
1               5                   10              


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<223>  It corresponds to the peptidic sequence (without the birradical 
       ligand) of the compounds IDP-P1708160 and IDP-P1708161

<400>  12

Ala Pro Lys Gly Val Ile Leu Lys Lys Ala Gly Ala Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound IDP-P1708160


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  The X residue at position 4 has formula (II) where R1 is -H and 
       it binds to the X residue at position 11 via a L birradical which
       is -(CH2)-S-(CH2)8-S-(CH2)-

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  The X residue at position 11 has formula (II) where R1 is -H

<400>  13

Ala Pro Lys Xaa Val Ile Leu Lys Lys Ala Xaa Ala Tyr Ile Leu Ser 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Compound IDP-P1708161


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  The X residue at position 4 has formula (II) where R1 is -H and 
       it binds to the X residue at position 11 via a L birradical which
       is -(CH2)-S-(CH2)-biphenyl-(CH2)-S-(CH2)-

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  The X residue at position 11 has formula (II) where R1 is -H

<400>  14

Ala Pro Lys Xaa Val Ile Leu Lys Lys Ala Xaa Ala Tyr Ile Leu Ser 
1               5                   10                  15      


