                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Puri, Raj K
       Zoon, Kathryn C
       Husain, Syed R
       Green, Daniel S
 
<120>  SYNERGISTIC COMBINATION OF IL4 RECEPTOR TARGETED AGENTS, 
       INTERFERON GAMMA, AND INTERFERON ALPHA FOR USE IN TREATING 
       OVARIAN CANCER

<130>  9531-99185-02

<150>  US 62/556,049
<151>  2017-09-08

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Glu Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  2
<211>  190
<212>  PRT
<213>  Mouse

<400>  2

Met Ala Arg Pro Phe Ala Phe Leu Met Val Leu Val Val Ile Ser Tyr 
1               5                   10                  15      


Trp Ser Thr Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Asn Leu 
            20                  25                  30          


Arg Asn Lys Lys Ile Leu Thr Leu Leu Ala Gln Met Arg Arg Leu Ser 
        35                  40                  45              


Pro Leu Ser Cys Leu Lys Asp Arg Lys Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Lys Val Asp Ala Gln Gln Ile Gln Glu Ala Gln Ala Ile Pro Val Leu 
65                  70                  75                  80  


Ser Glu Leu Thr Gln Gln Ile Leu Thr Leu Phe Thr Ser Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Ala Thr Leu Leu Asp Ser Phe Cys Thr Gly Leu 
            100                 105                 110         


His Gln Leu Leu Asn Asp Leu Gln Gly Cys Leu Met Gln Leu Val Gly 
        115                 120                 125             


Met Lys Glu Leu Pro Leu Thr Gln Glu Asp Ser Gln Leu Ala Met Lys 
    130                 135                 140                 


Lys Tyr Phe His Arg Ile Thr Val Tyr Leu Arg Glu Lys Lys His Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Val Trp Arg Ala Leu Ser 
                165                 170                 175     


Ser Ser Val Asn Leu Leu Ala Arg Leu Ser Glu Glu Lys Glu 
            180                 185                 190 


<210>  3
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  4
<211>  155
<212>  PRT
<213>  Mouse

<400>  4

Met Asn Ala Thr His Cys Ile Leu Ala Leu Gln Leu Phe Leu Met Ala 
1               5                   10                  15      


Val Ser Gly Cys Tyr Cys His Gly Thr Val Ile Glu Ser Leu Glu Ser 
            20                  25                  30          


Leu Asn Asn Tyr Phe Asn Ser Ser Gly Ile Asp Val Glu Glu Lys Ser 
        35                  40                  45              


Leu Phe Leu Asp Ile Trp Arg Asn Trp Gln Lys Asp Gly Asp Met Lys 
    50                  55                  60                  


Ile Leu Gln Ser Gln Ile Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val 
65                  70                  75                  80  


Leu Lys Asp Asn Gln Ala Ile Ser Asn Asn Ile Ser Val Ile Glu Ser 
                85                  90                  95      


His Leu Ile Thr Asn Phe Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala 
            100                 105                 110         


Phe Met Ser Ile Ala Lys Phe Glu Val Asn Asn Pro Gln Val Gln Arg 
        115                 120                 125             


Gln Ala Phe Asn Glu Leu Ile Arg Val Val His Gln Leu Ser Pro Glu 
    130                 135                 140                 


Ser Ser Leu Arg Lys Arg Lys Arg Ser Arg Cys 
145                 150                 155 


<210>  5
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  5
caaggttcag agtcacccat ctcagcaagc ccagaagtat ctgcaatatc tacgatggcc       60

tcgccctttg ctttactgat ggtcctggtg gtgctcagct gcaagtcaag ctgctctctg      120

ggctgtgatc tccctgagac ccacagcctg gataacagga ggaccttgat gctcctggca      180

caaatgagca gaatctctcc ttcctcctgt ctgatggaca gacatgactt tggatttccc      240

caggaggagt ttgatggcaa ccagttccag aaggctccag ccatctctgt cctccatgag      300

ctgatccagc agatcttcaa cctctttacc acaaaagatt catctgctgc ttgggatgag      360

gacctcctag acaaattctg caccgaactc taccagcagc tgaatgactt ggaagcctgt      420

gtgatgcagg aggagagggt gggagaaact cccctgatga atgcggactc catcttggct      480

gtgaagaaat acttccgaag aatcactctc tatctgacag agaagaaata cagcccttgt      540

gcctgggagg ttgtcagagc agaaatcatg agatccctct ctttatcaac aaacttgcaa      600

gaaagattaa ggaggaagga ataacatctg gtccaacatg aaaacaattc ttattgactc      660

atacaccagg tcacgctttc atgaattctg tcatttcaaa gactctcacc cctgctataa      720

ctatgaccat gctgataaac tgatttatct atttaaatat ttatttaact attcataaga      780

tttaaattat ttttgttcat ataacgtcat gtgcaccttt acactgtggt tagtgtaata      840

aaacatgttc cttatattta ctc                                              863


<210>  6
<211>  570
<212>  DNA
<213>  Mouse

<400>  6
atggctaggc tctgtgcttt cctgatggtc ctggcggtgc tgagctactg gccaacctgc       60

tctctaggat gtgaccttcc tcagactcat aacctcagga acaagagagc cttgacactc      120

ctggtacaaa tgaggagact ctcccctctc tcctgcctga aggacaggaa ggactttgga      180

ttcccgcagg agaaggtgga tgcccagcag atcaagaagg ctcaagccat ccctgtcctg      240

agtgagctga cccagcagat cctgaacatc ttcacatcaa aggactcatc tgctgcatgg      300

aatacaaccc tcctagactc attctgcaat gacctccacc agcagctcaa tgacctgcaa      360

ggctgtctga tgcagcaggt gggggtgcag gaatttcccc tgacccagga agatgccctg      420

ctggctgtga ggaaatactt ccacaggatc actgtgtacc tgagagagaa gaaacacagc      480

ccctgtgcct gggaggtggt cagagcagaa gtctggagag ccctgtcttc ctctgccaat      540

gtgctgggaa gactgagaga agagaaatga                                       570


<210>  7
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  7
cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60

ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120

gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180

cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240

aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300

tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360

ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420

gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480

actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540

gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600

tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660

tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720

caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780

tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840

ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900

cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960

aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020

tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080

catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140

aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200

agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1240


<210>  8
<211>  1210
<212>  DNA
<213>  Mouse

<400>  8
tatagctgcc atcggctgac ctagagaaga cacatcagct gatcctttgg accctctgac       60

ttgagacaga agttctgggc ttctcctcct gcggcctagc tctgagacaa tgaacgctac      120

acactgcatc ttggctttgc agctcttcct catggctgtt tctggctgtt actgccacgg      180

cacagtcatt gaaagcctag aaagtctgaa taactatttt aactcaagtg gcatagatgt      240

ggaagaaaag agtctcttct tggatatctg gaggaactgg caaaaggatg gtgacatgaa      300

aatcctgcag agccagatta tctctttcta cctcagactc tttgaagtct tgaaagacaa      360

tcaggccatc agcaacaaca taagcgtcat tgaatcacac ctgattacta ccttcttcag      420

caacagcaag gcgaaaaagg atgcattcat gagtattgcc aagtttgagg tcaacaaccc      480

acaggtccag cgccaagcat tcaatgagct catccgagtg gtccaccagc tgttgccgga      540

atccagcctc aggaagcgga aaaggagtcg ctgctgattc ggggtgggga agagattgtc      600

ccaataagaa taattctgcc agcactattt gaatttttaa atctaaacct atttattaat      660

atttaaaact atttatatgg agaatctatt ttagatgcat caaccaaaga agtatttata      720

gtaacaactt atatgtgata agagtgaatt cctattaata tatgtgttat ttataatttc      780

tgtctcctca actatttctc tttgaccaat taattattct ttctgactaa ttagccaaga      840

ctgtgattgc ggggttgtat ctgggggtgg gggacagcca agcggctgac tgaactcaga      900

ttgtagcttg tacctttact tcactgacca ataagaaaca ttcagagctg cagtgacccc      960

gggaggtgct gctgatggga ggagatgtct acactccggg ccagcgcttt aacagcaggc     1020

cagacagcac tcgaatgtgt caggtagtaa caggctgtcc ctgaaagaaa gcagtgtctc     1080

aagagacttg acacctggtg cttccctata cagctgaaaa ctgtgactac acccgaatga     1140

caaataactc gctcatttat agtttatcac tgtctaattg catatgaata aagtatacct     1200

ttgcaaccaa                                                            1210


<210>  9
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Leu Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


<210>  10
<211>  140
<212>  PRT
<213>  Mouse

<400>  10

Met Gly Leu Asn Pro Gln Leu Val Val Ile Leu Leu Phe Phe Leu Glu 
1               5                   10                  15      


Cys Thr Arg Ser His Ile His Gly Cys Asp Lys Asn His Leu Arg Glu 
            20                  25                  30          


Ile Ile Gly Ile Leu Asn Glu Val Thr Gly Glu Gly Thr Pro Cys Thr 
        35                  40                  45              


Glu Met Asp Val Pro Asn Val Leu Thr Ala Thr Lys Asn Thr Thr Glu 
    50                  55                  60                  


Ser Glu Leu Val Cys Arg Ala Ser Lys Val Leu Arg Ile Phe Tyr Leu 
65                  70                  75                  80  


Lys His Gly Lys Thr Pro Cys Leu Lys Lys Asn Ser Ser Val Leu Met 
                85                  90                  95      


Glu Leu Gln Arg Leu Phe Arg Ala Phe Arg Cys Leu Asp Ser Ser Ile 
            100                 105                 110         


Ser Cys Thr Met Asn Glu Ser Lys Ser Thr Ser Leu Lys Asp Phe Leu 
        115                 120                 125             


Glu Ser Leu Lys Ser Ile Met Gln Met Asp Tyr Ser 
    130                 135                 140 


<210>  11
<211>  614
<212>  DNA
<213>  Homo sapiens

<400>  11
gatcgttagc ttctcctgat aaactaattg cctcacattg tcactgcaaa tcgacaccta       60

ttaatgggtc tcacctccca actgcttccc cctctgttct tcctgctagc atgtgccggc      120

aactttgtcc acggacacaa gtgcgatatc accttacagg agatcatcaa aactttgaac      180

agcctcacag agcagaagac tctgtgcacc gagttgaccg taacagacat ctttgctgcc      240

tccaagaaca caactgagaa ggaaaccttc tgcagggctg cgactgtgct ccggcagttc      300

tacagccacc atgagaagga cactcgctgc ctgggtgcga ctgcacagca gttccacagg      360

cacaagcagc tgatccgatt cctgaaacgg ctcgacagga acctctgggg cctggcgggc      420

ttgaattcct gtcctgtgaa ggaagccaac cagagtacgt tggaaaactt cttggaaagg      480

ctaaagacga tcatgagaga gaaatattca aagtgttcga gctgaatatt ttaatttatg      540

agtttttgat agctttattt tttaagtatt tatatattta taactcatca taaaataaag      600

tatatataga atct                                                        614


<210>  12
<211>  605
<212>  DNA
<213>  Mouse

<400>  12
ggatccccgg gcagagctgg ggggggattt gttagcatct cttgataaac ttaattgtct       60

ctcgtcactg acggcacaga gctattgatg ggtctcaacc cccagctagt tgtcatcctg      120

ctcttctttc tcgaatgtac caggagccat atccacggat gcgacaaaaa tcacttgaga      180

gagatcatcg gcattttgaa cgaggtcaca ggagaaggga cgccatgcac ggagatggat      240

gtgccaaacg tcctcacagc aacgaagaac accacagaga gtgagctcgt ctgtagggct      300

tccaaggtgc ttcgcatatt ttatttaaaa catgggaaaa ctccatgctt gaagaagaac      360

tctagtgttc tcatggagct gcagagactc tttcgggctt ttcgatgcct ggattcatcg      420

ataagctgca ccatgaatga gtccaagtcc acatcactga aagacttcct ggaaagccta      480

aagagcatca tgcaaatgga ttactcgtag tactgagcca ccatgcttta acttatgaat      540

ttttaatggt tttattttaa tatttatata tttataattc ataaaataaa atatttgtat      600

aatgt                                                                  605


<210>  13
<211>  638
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PE

<400>  13

Met His Leu Thr Pro His Trp Ile Pro Leu Val Ala Ser Leu Gly Leu 
1               5                   10                  15      


Leu Ala Gly Gly Ser Phe Ala Ser Ala Ala Glu Glu Ala Phe Asp Leu 
            20                  25                  30          


Trp Asn Glu Cys Ala Lys Ala Cys Val Leu Asp Leu Lys Asp Gly Val 
        35                  40                  45              


Arg Ser Ser Arg Met Ser Val Asp Pro Ala Ile Ala Asp Thr Asn Gly 
    50                  55                  60                  


Gln Gly Val Leu His Tyr Ser Met Val Leu Glu Gly Gly Asn Asp Ala 
65                  70                  75                  80  


Leu Lys Leu Ala Ile Asp Asn Ala Leu Ser Ile Thr Ser Asp Gly Leu 
                85                  90                  95      


Thr Ile Arg Leu Glu Gly Gly Val Glu Pro Asn Lys Pro Val Arg Tyr 
            100                 105                 110         


Ser Tyr Thr Arg Gln Ala Arg Gly Ser Trp Ser Leu Asn Trp Leu Val 
        115                 120                 125             


Pro Ile Gly His Glu Lys Pro Ser Asn Ile Lys Val Phe Ile His Glu 
    130                 135                 140                 


Leu Asn Ala Gly Asn Gln Leu Ser His Met Ser Pro Ile Tyr Thr Ile 
145                 150                 155                 160 


Glu Met Gly Asp Glu Leu Leu Ala Lys Leu Ala Arg Asp Ala Thr Phe 
                165                 170                 175     


Phe Val Arg Ala His Glu Ser Asn Glu Met Gln Pro Thr Leu Ala Ile 
            180                 185                 190         


Ser His Ala Gly Val Ser Val Val Met Ala Gln Ala Gln Pro Arg Arg 
        195                 200                 205             


Glu Lys Arg Trp Ser Glu Trp Ala Ser Gly Lys Val Leu Cys Leu Leu 
    210                 215                 220                 


Asp Pro Leu Asp Gly Val Tyr Asn Tyr Leu Ala Gln Gln Arg Cys Asn 
225                 230                 235                 240 


Leu Asp Asp Thr Trp Glu Gly Lys Ile Tyr Arg Val Leu Ala Gly Asn 
                245                 250                 255     


Pro Ala Lys His Asp Leu Asp Ile Lys Pro Thr Val Ile Ser His Arg 
            260                 265                 270         


Leu His Phe Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln 
        275                 280                 285             


Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg 
    290                 295                 300                 


Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val 
305                 310                 315                 320 


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val 
                325                 330                 335     


Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu 
            340                 345                 350         


Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala 
        355                 360                 365             


Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu 
    370                 375                 380                 


Ala Gly Ala Ala Ser Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala 
385                 390                 395                 400 


Ala Gly Glu Cys Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu 
                405                 410                 415     


Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Ile 
            420                 425                 430         


Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu 
        435                 440                 445             


Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr 
    450                 455                 460                 


His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val 
465                 470                 475                 480 


Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile 
                485                 490                 495     


Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro 
            500                 505                 510         


Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val 
        515                 520                 525             


Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala 
    530                 535                 540                 


Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu 
545                 550                 555                 560 


Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg 
                565                 570                 575     


Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile 
            580                 585                 590         


Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp 
        595                 600                 605             


Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp 
    610                 615                 620                 


Tyr Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
625                 630                 635             


<210>  14
<211>  1917
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PE

<400>  14
atgcacctga taccccattg gatccccctg gtcgccagcc tcggcctgct cgccggcggc       60

tcgttcgcgt ccgccgccga ggaagccttc gacctctgga acgaatgcgc caaggcctgc      120

gtgctcgacc tcaaggacgg cgtgcgttcc agccgcatga gcgtcgaccc ggccatcgcc      180

gacaccaacg gccagggcgt gctgcactac tccatggtcc tggagggcgg caacgacgcg      240

ctcaagctgg ccatcgacaa cgccctcagc atcaccagcg acggcctgac catccgcctc      300

gaaggcggcg tcgagccgaa caagccggtg cgctacagct acacgcgcca ggcgcgcggc      360

agttggtcgc tgaactggct ggtgccgatc ggccacgaga agccttcgaa catcaaggtg      420

ttcatccacg aactgaacgc cggtaaccag ctcagccaca tgtcgccgat ctacaccatc      480

gagatgggcg acgagttgct ggcgaagctg gcgcgcgatg ccaccttctt cgtcagggcg      540

cacgagagca acgagatgca gccgacgctc gccatcagcc atgccggggt cagcgtggtc      600

atggcccagg cccagccgcg ccgggaaaag cgctggagcg aatgggccag cggcaaggtg      660

ttgtgcctgc tcgacccgct ggacggggtc tacaactacc tcgcccagca gcgctgcaac      720

ctcgacgata cctgggaagg caagatctac cgggtgctcg ccggcaaccc ggcgaagcat      780

gacctggaca tcaagcccac ggtcatcagt catcgcctgc acttccccga gggcggcagc      840

ctggccgcgc tgaccgcgca ccaggcttgc cacctgccgc tggagacctt cacccgtcat      900

cgccagccgc gcggctggga acaactggag cagtgcggct atccggtgca gcggctggtc      960

gccctctacc tggcggcgcg actgtcgtgg aaccaggtcg accaggtgat ccgcaacgcc     1020

ctggccagcc ccggcagcgg cggcgacctg ggcgaagcga tccgcgagca gccggagcag     1080

gcccgtctgg ccctgaccct ggccgccgcc gagagcgagc gcttcgtccg gcagggcacc     1140

ggcaacgacg aggccggcgc ggccagcgcc gacgtggtga gcctgacctg cccggtcgcc     1200

gccggtgaat gcgcgggccc ggcggacagc ggcgacgccc tgctggagcg caactatccc     1260

actggcgcgg agttcctcgg cgacggcggc gacgtcagct tcagcacccg cggcacgcag     1320

aactggacgg tggagcggct gctccaggcg caccgccaac tggaggagcg cggctatgta     1380

ttcgtcggct accacggcac cttcctcgaa gcggcgcaaa gcatcgtctt cggcggggtg     1440

cgcgcgcgca gccaggacct cgacgcgatc tggcgcggtt tctatatcgc cggcgatccg     1500

gcgctggcct acggctacgc ccaggaccag gaacccgacg cgcgcggccg gatccgcaac     1560

ggtgccctgc tgcgggtcta tgtgccgcgc tcgagcctgc cgggcttcta ccgcaccggc     1620

ctgaccctgg ccgcgccgga ggcggcgggc gaggtcgaac ggctgatcgg ccatccgctg     1680

ccgctgcgcc tggacgccat caccggcccc gaggaggaag gcgggcgcct ggagaccatt     1740

ctcggctggc cgctggccga gcgcaccgtg gtgattccct cggcgatccc caccgacccg     1800

cgcaacgtcg gcggcgacct cgacccgtcc agcatccccg acaaggaaca ggcgatcagc     1860

gccctgccgg actacgccag ccagcccggc aaaccgccgc gcgaggacct gaagtaa        1917


<210>  15
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL4-PE38KDEL

<400>  15

His Met Asp Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val 
1               5                   10                  15      


Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly 
            20                  25                  30          


Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu 
        35                  40                  45              


Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys 
    50                  55                  60                  


Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg 
65                  70                  75                  80  


Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser Lys Cys 
                85                  90                  95      


Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu 
            100                 105                 110         


Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala 
        115                 120                 125             


Ser Lys Ala Ser Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr 
    130                 135                 140                 


Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg 
145                 150                 155                 160 


Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln 
                165                 170                 175     


Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val 
            180                 185                 190         


Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp 
        195                 200                 205             


Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu 
    210                 215                 220                 


Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly 
225                 230                 235                 240 


Asn Asp Glu Ala Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala 
                245                 250                 255     


Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly 
            260                 265                 270         


Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu 
        275                 280                 285             


Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe 
    290                 295                 300                 


Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe 
305                 310                 315                 320 


Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly 
                325                 330                 335     


Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp 
            340                 345                 350         


Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg 
        355                 360                 365             


Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu 
    370                 375                 380                 


Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly 
385                 390                 395                 400 


His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu 
                405                 410                 415     


Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr 
            420                 425                 430         


Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly 
        435                 440                 445             


Asp Leu Asp Pro Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala 
    450                 455                 460                 


Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Pro Lys Asp Glu Leu 
465                 470                 475                 480 


<210>  16
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL4-PE38KDEL

<400>  16
catatggaca caactgagaa ggaaaccttc tgcagggctg cgactgtgct ccggcagttc       60

tacagccacc atgagaagga cactcgctgc ctgggtgcga ctgcacagca gttccacagg      120

cacaagcagc tgatccgatt cctgaaacgg ctcgacagga acctctgggg cctggcgggc      180

ttgaattcct gtcctgtgaa ggaagccaac cagagtacgt tggaaaactt cttggaaagg      240

ctaaagacga tcatgagaga gaaatattca aagtgttcgt ccaagtgcga tatcacctta      300

caggagatca tcaaaacttt gaacagcctc acagagcaga agactctgtg caccgagttg      360

accgtaacag acatctttgc tgcctccaaa gcttccggag gtcccgaggg cggcagcctg      420

gccgcgctga ccgcgcacca ggcttgccac ctgccgctgg agactttcac ccgtcatcgc      480

cagccgcgcg gctgggaaca actggagcag tgcggctatc cggtgcagcg gctggtcgcc      540

ctctacctgg cggcgcggct gtcgtggaac caggtcgacc aggtgatccg caacgccctg      600

gccagccccg gcagcggcgg cgacctgggc gaagcgatcc gcgagcagcc ggagcaggcc      660

cgtctggccc tgaccctggc cgccgccgag agcgagcgct tcgtccggca gggcaccggc      720

aacgacgagg ccggcgcggc caacggcccg gcggacagcg gcgacgccct gctggagcgc      780

aactatccca ctggcgcgga gttcctcggc gacggcggcg acgtcagctt cagcacccgc      840

ggcacgcaga actggacggt ggagcggctg ctccaggcgc accgccaact ggaggagcgc      900

ggctatgtgt tcgtcggcta ccacggcacc ttcctcgaag cggcgcaaag catcgtcttc      960

ggcggggtgc gcgcgcgcag ccaggacctc gacgcgatct ggcgcggttt ctatatcgcc     1020

ggcgatccgg cgctggccta cggctacgcc caggaccagg aacccgacgc acgcggccgg     1080

atccgcaacg gtgccctgct gcgggtctat gtgccgcgct cgagcctgcc gggcttctac     1140

cgcaccagcc tgaccctggc cgcgccggag gcggcgggcg aggtcgaacg gctgatcggc     1200

catccgctgc cgctgcgcct ggacgccatc accggccccg aggaggaagg cgggcgcctg     1260

gagaccattc tcggctggcc gctggccgag cgcaccgtgg tgattccctc ggcgatcccc     1320

accgacccgc gcaacgtcgg cggcgacctc gacccgtcca gcatccccga caaggaacag     1380

gcgatcagcg ccctgccgga ctacgccagc cagcccggca aaccgccgaa agacgagctc     1440

taagaattcg gctgctaaca aagcccgaaa ggaagctgag tt                        1482


