                               SEQUENCE LISTING

<110> THE NEMOURS FOUNDATION
      SEIKAGAKU CORPORATION
 
<120> AN AGENT, A DEVICE AND A BLOOD-CIRCULATION SYSTEM FOR TREATING 
      LYSOSOMAL STORAGE DISEASES, AND A METHOD FOR TREATING LYSOSOMAL 
      STORAGE DISEASES

<130> 116227-0109

<140>
<141>

<150> 62/617,940 
<151> 2018-01-16

<150> 62/556,644
<151> 2017-09-11

<150> 62/556,076
<151> 2017-09-08

<160> 5     

<170> PatentIn version 3.5

<210> 1
<211> 1936
<212> PRT
<213> Bacillus circulans

<400> 1
Met Ser Ser Arg Leu Lys Arg Lys Cys Ser Met Leu Leu Thr Phe Thr 
1               5                   10                  15      


Met Ile Phe Gln Leu Leu Gly Leu Phe Leu Phe Lys Gly Glu Ile Val 
            20                  25                  30          


Ser Ala Ser Ile Arg Gln Asp Pro Thr Thr Gly Asn Tyr Tyr Lys Asn 
        35                  40                  45              


Val Pro Leu Val Gly Ala Asp Phe Asp Asp Ala Ser Asn Ser Asn Ile 
    50                  55                  60                  


Val Ala Lys Gly Thr Trp Asp Asp Asn Thr Ala Pro Leu Asn Thr Phe 
65                  70                  75                  80  


Phe Val Asp Lys Gly Thr Ala Thr Asp Gly Gly Phe Thr Thr Ala Arg 
                85                  90                  95      


Ile Thr Thr Val Thr Asp Gln Val Tyr Glu Gly Gly Ser Leu Gln Phe 
            100                 105                 110         


Gly Asp Gly Ser Thr Tyr Pro Ile Asn Leu Asn Tyr Lys Val Asp Gly 
        115                 120                 125             


Leu Glu Val Gly Ala Thr Tyr Arg Leu Ser Ala Tyr Met Lys Leu Phe 
    130                 135                 140                 


Pro Gly Tyr Pro Ala Lys Gly Gly Gln Phe Gly Val Lys Asn His Asp 
145                 150                 155                 160 


Thr Ala Asn Tyr Thr Thr Gly Gly Glu Thr Lys Ser Val Asn Phe Ser 
                165                 170                 175     


Thr Val Thr Ala Asp Trp Lys Glu Tyr Ser Val Thr Phe Thr Pro Thr 
            180                 185                 190         


Tyr Pro His Ala Lys Ile Phe Phe Trp Gly Ser Asn Asn Leu Pro Lys 
        195                 200                 205             


Val Leu Val Asp Lys Leu Arg Leu Glu Lys Val Leu Glu His Pro Gly 
    210                 215                 220                 


Pro Ala Ala Pro Ala Val Thr Ala Asp Asp Val Asn Asn Ile Val Val 
225                 230                 235                 240 


Gly Ile Asp Glu Thr Met Glu Tyr Asn Ile Asn Gly Ala Gly Trp Val 
                245                 250                 255     


Ala Tyr Lys Glu Tyr Ala Lys Pro Asp Leu Lys Gly Asp Leu Ile Val 
            260                 265                 270         


Gln Ile Arg Val Lys Glu Thr Leu Asn Thr Leu Ala Gly Glu Val Thr 
        275                 280                 285             


Thr Leu Thr Phe Thr Ala Gln Asn Asp Pro Ala Pro Gly Gln Pro Glu 
    290                 295                 300                 


Gln Leu Leu Leu Lys Asp Gly Asp Phe Glu Ala Gly Ala Ala Ser Val 
305                 310                 315                 320 


Thr Thr Asp Thr Asn Val Gln Asn Gln Phe Phe Ser Lys Asn Asn Gln 
                325                 330                 335     


Tyr Glu Ile Val Thr Gly Asp Thr Ala Ser Gly Gln Tyr Ala Leu Lys 
            340                 345                 350         


Leu Arg Ser Pro Glu Thr Ile Gly Tyr His Lys Thr Asp Leu Lys Pro 
        355                 360                 365             


Ser Thr Lys Tyr Gln Ile Ser Phe Met Ala Lys Val Gly Ser Ala Ser 
    370                 375                 380                 


Gln Lys Leu Ser Phe Arg Ile Ser Gly Tyr Lys Asn Asp Asn Pro Tyr 
385                 390                 395                 400 


Asp Leu Asp Asn Val Met Asn Tyr Ile Glu His Thr Gln Met Lys Asn 
                405                 410                 415     


Thr Gly Trp Ser Arg Phe Tyr Tyr Asp Leu Glu Thr Gly Pro Ser Ala 
            420                 425                 430         


Thr Ser Ala Phe Ile Asp Phe Ser Thr Ala Ala Gly Ser Thr Ala Trp 
        435                 440                 445             


Ile Asp Asp Val Lys Leu Val Glu Gln Gly Pro Ala Asp Pro Pro Val 
    450                 455                 460                 


Thr Glu Pro Thr Leu Ser Arg Gly Ser Arg Leu Phe Leu Glu Lys Gly 
465                 470                 475                 480 


Leu Gln Ile Gln Ser Trp Val Pro Thr Asp Val Ala Tyr Ala Thr Arg 
                485                 490                 495     


Lys Trp Met Lys Pro Pro Thr Ala Glu Glu Ile Val Asp Leu Gly Leu 
            500                 505                 510         


Thr Thr Val Gln Tyr Asn Asp Ala Pro Asn Tyr Ser Lys Thr Leu His 
        515                 520                 525             


Glu Glu Tyr Lys Lys Leu Gln Gln Thr Asn Pro Ser Leu Pro Asp Leu 
    530                 535                 540                 


Lys Trp Gly Val Ala Phe Gly Pro Asn Ala Asn His Leu Ser Ser Ser 
545                 550                 555                 560 


Tyr Phe Asp Ser Glu Thr Ile Ala Lys His Asp Pro Asn Lys Thr Gly 
                565                 570                 575     


Ala Pro Thr Glu Glu Gln Lys Ala Arg Gly Phe Leu Thr Pro Asp Gln 
            580                 585                 590         


Leu Ala Asn Val Gln Asn Leu Asn Asn Ile Gly Phe Gly Asp Glu Glu 
        595                 600                 605             


Asp Tyr Ser Asp Thr Leu Thr Gln Thr Leu Lys Glu Trp Phe Glu Val 
    610                 615                 620                 


Ser Lys Lys His Tyr Pro Asn Val Leu Val His His Asn Glu Val Gly 
625                 630                 635                 640 


Asn Thr Pro Pro Pro Thr Met Ser Leu Ile Ser Thr Phe Asn Glu Asn 
                645                 650                 655     


Met Leu Arg Lys Tyr Met Arg Thr Ala Lys Pro Asp Phe Ile Thr Tyr 
            660                 665                 670         


Asp Met Tyr Tyr Phe Arg Glu Asn Arg Gln Ser Ser Glu Val Gly Gly 
        675                 680                 685             


Thr Val Ile Pro Phe Tyr Asp Asp Leu Asn Arg Tyr Arg Lys Val Ala 
    690                 695                 700                 


Ser Glu Gly Tyr Asp Gly Ser Gly Leu Ser Pro Ile Pro Phe Gly Thr 
705                 710                 715                 720 


Tyr Leu Gln Gly Trp Arg Thr Gly Pro Gly Ala Ala Thr Tyr Glu Lys 
                725                 730                 735     


Arg Gly Asp Gly Trp Tyr Glu Ile Thr Glu Ser Gln Ala Tyr Leu Ser 
            740                 745                 750         


Ala Phe Ala Asn Trp Thr Phe Gly Ala Lys Trp Leu Ser Met Phe Arg 
        755                 760                 765             


Trp Ile Glu Asp Thr Pro Gly Tyr Leu Phe Ser Asp Tyr Arg Pro Asp 
    770                 775                 780                 


Glu Asp Gly Asn Trp Pro Lys Tyr His Ile Tyr Gly Gln Tyr Lys Glu 
785                 790                 795                 800 


Met Phe Arg Gln Ser Lys Asn Leu Gly Glu His Leu Ile Arg Ile Asn 
                805                 810                 815     


Asn Lys Asp Val Val Ile Val Pro Gly Gln His Met Lys Asp Gly Gln 
            820                 825                 830         


Ile Thr Lys Asn Asn Arg Pro Lys Asp Asn Pro Glu Trp Thr Lys Ser 
        835                 840                 845             


Gly Asp Arg Ala Phe Ile Asp Ser Leu Glu Ile Ser Asn Leu Gly Lys 
    850                 855                 860                 


Thr Asn His Ser Leu Lys Gly Asp Val Phe Ile Gly Tyr Phe Asp Pro 
865                 870                 875                 880 


Leu Pro Gly Ile Asp Thr Thr Gln Phe Phe Thr Ser Thr Ala Pro Lys 
                885                 890                 895     


Tyr Phe Met Leu Leu Asn Gly Leu Thr Ser Gly Gln Gly Leu Pro Ala 
            900                 905                 910         


Glu Glu Gln Thr Gly Ser Ser Tyr Glu Thr Arg Gln Glu Ile Lys Val 
        915                 920                 925             


Thr Phe Asp Leu Ser Gly Gly Gln Ala Arg Ala Asp Gln Leu Arg Lys 
    930                 935                 940                 


Val Ser Arg Leu Thr Gly Glu Leu Val Ala Ala Pro Leu Lys Asp Leu 
945                 950                 955                 960 


Gly Asn Gly Lys Tyr Glu Met Thr Val Val Leu Gly Gly Gly Met Ala 
                965                 970                 975     


Asp Leu Tyr Phe Trp Glu Leu Gly Ser Leu Asn Thr Gly Asn Ser Lys 
            980                 985                 990         


Pro Val Val Ala Asp Thr Pro His  Asp Val Arg Leu Thr  Gly Asp Pro 
        995                 1000                 1005             


Lys Tyr  Ala Lys Asn Arg Glu  Ile Arg Asp Leu Thr  Gly Lys Thr 
    1010                 1015                 1020             


Val Thr  Val Gly Trp Ile Lys  Asp Thr Tyr Ser Pro  Val Pro Gln 
    1025                 1030                 1035             


Pro Leu  Ile His Tyr Asn Phe  Ser Phe Thr Lys Asp  Gln Asn Gly 
    1040                 1045                 1050             


Lys Leu  Gln Pro Met Lys Asn  Pro Asp Ile Leu Ser  Tyr Phe Thr 
    1055                 1060                 1065             


Arg Tyr  Tyr Glu Asn Thr Leu  Trp Asn Lys Arg Val  Glu Arg Ile 
    1070                 1075                 1080             


Gln Lys  Glu Ser Asn Val Lys  Leu Glu Phe Val Ala  Asp Ile Ala 
    1085                 1090                 1095             


Trp Thr  Lys Gln Glu Leu Met  Asp Asn Ile Arg Lys  Val Lys Glu 
    1100                 1105                 1110             


Gly Gln  Thr Val Asp Gly Met  Pro Asp Ile Leu Ile  Val Pro Asp 
    1115                 1120                 1125             


Glu Trp  Thr Trp Ser Gly Leu  Ile Gln Asn Glu Met  Ile Leu Pro 
    1130                 1135                 1140             


Ala Ser  Ser Phe Ser Glu Phe  Asp Phe Thr Glu Arg  Lys Trp Asn 
    1145                 1150                 1155             


Lys Ser  Tyr Lys Ala Met Thr  Thr Trp Lys Asp Gln  Ile Tyr Gly 
    1160                 1165                 1170             


Met Tyr  Ala Gly Pro Thr Met  Asn Ser Thr Gly Leu  Phe Val Asn 
    1175                 1180                 1185             


Lys Ala  Leu Gln Ala Ser Ile  Gly Val Thr Asp Asp  Leu Met Ala 
    1190                 1195                 1200             


Leu Gln  Gln Asn Asn Ala Trp  Asp Trp Asn Lys Leu  Arg Glu Val 
    1205                 1210                 1215             


Ala Ser  Ala Phe Gln Ala Ser  Ala Asn Arg Glu Gly  Lys Tyr Leu 
    1220                 1225                 1230             


Leu Ala  Gly Thr Asp Glu Leu  Phe Lys Gln Met Val  Tyr Ala Asn 
    1235                 1240                 1245             


Gly Ala  Ala Arg Gly Ser Val  Gly Gly Ala Met Asn  Gln Glu Phe 
    1250                 1255                 1260             


Asp Leu  Thr Ser Ser Ser Phe  Arg Glu Ala Ala Glu  Leu Tyr Ser 
    1265                 1270                 1275             


Glu Leu  His Ala Ala Gly Leu  Ile Ala Ala Lys Pro  Glu Gly Ala 
    1280                 1285                 1290             


Thr Asp  Asp Trp Tyr Val Glu  Gln Phe Ser Lys Asn  Asn Ile Leu 
    1295                 1300                 1305             


Phe Leu  Ala Leu Pro Tyr Gln  Gln Thr Val Asp Lys  Leu Lys Phe 
    1310                 1315                 1320             


Ser Tyr  Thr Asn Gln Asp Ala  Val Ile Glu Met Lys  Glu Gly Ser 
    1325                 1330                 1335             


Phe Leu  Gly Gln Pro Ala Leu  Ile Pro Thr Ile Val  Asp Ala Tyr 
    1340                 1345                 1350             


Glu Thr  Ala Tyr Pro Asp Gly  Ile Tyr Lys Met Ala  Gln Gly Asp 
    1355                 1360                 1365             


Trp Val  Phe Leu Met Phe Pro  Lys Gly Pro Ser Ala  Thr Gly Tyr 
    1370                 1375                 1380             


Ala Ala  Met Ile Asp Asn Pro  Ala Tyr Pro Val Leu  Leu Ser Ser 
    1385                 1390                 1395             


Ser Ala  Asn Pro Ala Asp Ala  Ala Tyr Val Trp Asn  Ile Leu Ser 
    1400                 1405                 1410             


His Glu  Phe Glu Gly Val Ala  Tyr Asp Arg Phe Leu  Lys Leu Tyr 
    1415                 1420                 1425             


Leu Asn  Gln Arg Glu Val Asp  Lys Thr Thr Leu Lys  Arg Ile Gly 
    1430                 1435                 1440             


Leu Lys  Glu Gly Val Trp Asp  Ser Tyr Ser Gly Thr  Gly Ala Trp 
    1445                 1450                 1455             


Glu Gln  Val Ile Lys Pro Gly  Val Leu Pro Met Leu  Gln Ala Gly 
    1460                 1465                 1470             


Val Ile  Asp Glu Ala Lys Leu  Ala Glu Leu Ser Val  Glu Ala Ala 
    1475                 1480                 1485             


Ser Tyr  Val Thr Asn Asn Met  Thr Lys Pro Ala Gln  Pro Gly Glu 
    1490                 1495                 1500             


Glu Pro  Gly Glu Glu Pro Gly  Glu Gln Pro Gly Glu  Gln Pro Gly 
    1505                 1510                 1515             


Glu Gln  Pro Gly Glu Gln Pro  Gly Glu Gln Pro Gly  Glu Gln Pro 
    1520                 1525                 1530             


Gly Glu  Gln Pro Gly Glu Gln  Pro Gly Glu Gln Pro  Gly Ala Gly 
    1535                 1540                 1545             


Asn Gly  Ser Glu Asn Gln Gly  Gly Asn Glu Asp Gln  Gly Gly Asn 
    1550                 1555                 1560             


Gly Ser  Gln Gly Gly Asn Gly  Pro Lys Pro Glu Lys  Ile Ile Val 
    1565                 1570                 1575             


Lys Pro  Gly Glu Leu Ile Ala  Val Glu Gly Lys Val  Thr Ile Val 
    1580                 1585                 1590             


Val Pro  Ala Gly Ala Thr Glu  Ile Val Leu Pro Pro  Gln Ala Ala 
    1595                 1600                 1605             


Glu Leu  Pro Gln Gln His Lys  Val Glu Leu Lys Thr  Asp Arg Val 
    1610                 1615                 1620             


Thr Leu  Glu Val Pro Ser Gly  Leu Leu Lys Lys Leu  Ala Ser Arg 
    1625                 1630                 1635             


Ile Ala  Asp Lys Asp Val Ser  Ile Ser Leu Lys Ala  Ala Pro Leu 
    1640                 1645                 1650             


Thr Ala  Ala Gln Ala Lys Asp  Ala Ile Ser Lys Asn  Lys Ser Val 
    1655                 1660                 1665             


Ser Pro  Ser Ala Ile Thr Leu  Ala Gly Gly Val Tyr  Asp Phe Lys 
    1670                 1675                 1680             


Leu Ser  Ala Ala Gly Ala Asn  Gly Ser Tyr Ala Glu  Leu Ser Glu 
    1685                 1690                 1695             


Phe Asp  Gln Pro Ile Thr Ile  Ser Leu Lys Ile Glu  Ser Gly Val 
    1700                 1705                 1710             


Asn Pro  Glu Gln Val Gly Ile  Tyr Tyr Ile Ser Gly  Asn Gly Lys 
    1715                 1720                 1725             


Leu Asp  Tyr Ile Gly Gly Glu  Tyr Arg Asp Gly Glu  Leu Ala Ala 
    1730                 1735                 1740             


Glu Val  Thr His Phe Ser Gln  Tyr Ala Val Leu Lys  Val Val Lys 
    1745                 1750                 1755             


Val Phe  Asp Asp Val Pro Ala  Gly His Trp Ala Glu  Gly Val Ile 
    1760                 1765                 1770             


Ser Lys  Leu Thr Ser Arg Leu  Met Val Asp Gly Thr  Ser Glu Thr 
    1775                 1780                 1785             


Thr Phe  Glu Pro Glu Arg Val  Val Thr Arg Ala Glu  Phe Thr Ala 
    1790                 1795                 1800             


Leu Leu  Ala Arg Ala Leu Lys  Leu Thr Ala Gly Gly  Thr Pro Thr 
    1805                 1810                 1815             


Phe Ala  Asp Val Lys Ala Gly  Asp Trp Tyr Ala Asp  Ala Val Thr 
    1820                 1825                 1830             


Ala Ala  Val Glu Ala Gly Ile  Ala Glu Gly Lys Ser  Ala Gly Gln 
    1835                 1840                 1845             


Phe Glu  Pro Gln Ala Arg Ile  Thr Arg Glu Glu Met  Val Val Met 
    1850                 1855                 1860             


Thr Met  Arg Ala Tyr Asn Lys  Ala Lys Asp Lys Gly  Pro Ser Thr 
    1865                 1870                 1875             


Gly Val  Glu Ala Ser Phe Thr  Asp Glu Asn Gln Ile  Ser Ala Trp 
    1880                 1885                 1890             


Ala Val  Glu Gln Val Lys Ala  Ala Ala Ala Leu Gln  Leu Ile Gln 
    1895                 1900                 1905             


Gly Arg  Ala Gln Gly Lys Phe  Glu Pro Gln Gly Thr  Ala Thr Arg 
    1910                 1915                 1920             


Ala Glu  Ala Val Gln Val Ile  Phe Asn Met Leu Leu  Lys 
    1925                 1930                 1935     


<210> 2
<211> 1468
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Ser Ile Arg Gln Asp Pro Thr Thr Gly Asn Tyr Tyr Lys Asn Val Pro 
1               5                   10                  15      


Leu Val Gly Ala Asp Phe Asp Asp Ala Ser Asn Ser Asn Ile Val Ala 
            20                  25                  30          


Lys Gly Thr Trp Asp Asp Asn Thr Ala Pro Leu Asn Thr Phe Phe Val 
        35                  40                  45              


Asp Lys Gly Thr Ala Thr Asp Gly Gly Phe Thr Thr Ala Arg Ile Thr 
    50                  55                  60                  


Thr Val Thr Asp Gln Val Tyr Glu Gly Gly Ser Leu Gln Phe Gly Asp 
65                  70                  75                  80  


Gly Ser Thr Tyr Pro Ile Asn Leu Asn Tyr Lys Val Asp Gly Leu Glu 
                85                  90                  95      


Val Gly Ala Thr Tyr Arg Leu Ser Ala Tyr Met Lys Leu Phe Pro Gly 
            100                 105                 110         


Tyr Pro Ala Lys Gly Gly Gln Phe Gly Val Lys Asn His Asp Thr Ala 
        115                 120                 125             


Asn Tyr Thr Thr Gly Gly Glu Thr Lys Ser Val Asn Phe Ser Thr Val 
    130                 135                 140                 


Thr Ala Asp Trp Lys Glu Tyr Ser Val Thr Phe Thr Pro Thr Tyr Pro 
145                 150                 155                 160 


His Ala Lys Ile Phe Phe Trp Gly Ser Asn Asn Leu Pro Lys Val Leu 
                165                 170                 175     


Val Asp Lys Leu Arg Leu Glu Lys Val Leu Glu His Pro Gly Pro Ala 
            180                 185                 190         


Ala Pro Ala Val Thr Ala Asp Asp Val Asn Asn Ile Val Val Gly Ile 
        195                 200                 205             


Asp Glu Thr Met Glu Tyr Asn Ile Asn Gly Ala Gly Trp Val Ala Tyr 
    210                 215                 220                 


Lys Glu Tyr Ala Lys Pro Asp Leu Lys Gly Asp Leu Ile Val Gln Ile 
225                 230                 235                 240 


Arg Val Lys Glu Thr Leu Asn Thr Leu Ala Gly Glu Val Thr Thr Leu 
                245                 250                 255     


Thr Phe Thr Ala Gln Asn Asp Pro Ala Pro Gly Gln Pro Glu Gln Leu 
            260                 265                 270         


Leu Leu Lys Asp Gly Asp Phe Glu Ala Gly Ala Ala Ser Val Thr Thr 
        275                 280                 285             


Asp Thr Asn Val Gln Asn Gln Phe Phe Ser Lys Asn Asn Gln Tyr Glu 
    290                 295                 300                 


Ile Val Thr Gly Asp Thr Ala Ser Gly Gln Tyr Ala Leu Lys Leu Arg 
305                 310                 315                 320 


Ser Pro Glu Thr Ile Gly Tyr His Lys Thr Asp Leu Lys Pro Ser Thr 
                325                 330                 335     


Lys Tyr Gln Ile Ser Phe Met Ala Lys Val Gly Ser Ala Ser Gln Lys 
            340                 345                 350         


Leu Ser Phe Arg Ile Ser Gly Tyr Lys Asn Asp Asn Pro Tyr Asp Leu 
        355                 360                 365             


Asp Asn Val Met Asn Tyr Ile Glu His Thr Gln Met Lys Asn Thr Gly 
    370                 375                 380                 


Trp Ser Arg Phe Tyr Tyr Asp Leu Glu Thr Gly Pro Ser Ala Thr Ser 
385                 390                 395                 400 


Ala Phe Ile Asp Phe Ser Thr Ala Ala Gly Ser Thr Ala Trp Ile Asp 
                405                 410                 415     


Asp Val Lys Leu Val Glu Gln Gly Pro Ala Asp Pro Pro Val Thr Glu 
            420                 425                 430         


Pro Thr Leu Ser Arg Gly Ser Arg Leu Phe Leu Glu Lys Gly Leu Gln 
        435                 440                 445             


Ile Gln Ser Trp Val Pro Thr Asp Val Ala Tyr Ala Thr Arg Lys Trp 
    450                 455                 460                 


Met Lys Pro Pro Thr Ala Glu Glu Ile Val Asp Leu Gly Leu Thr Thr 
465                 470                 475                 480 


Val Gln Tyr Asn Asp Ala Pro Asn Tyr Ser Lys Thr Leu His Glu Glu 
                485                 490                 495     


Tyr Lys Lys Leu Gln Gln Thr Asn Pro Ser Leu Pro Asp Leu Lys Trp 
            500                 505                 510         


Gly Val Ala Phe Gly Pro Asn Ala Asn His Leu Ser Ser Ser Tyr Phe 
        515                 520                 525             


Asp Ser Glu Thr Ile Ala Lys His Asp Pro Asn Lys Thr Gly Ala Pro 
    530                 535                 540                 


Thr Glu Glu Gln Lys Ala Arg Gly Phe Leu Thr Pro Asp Gln Leu Ala 
545                 550                 555                 560 


Asn Val Gln Asn Leu Asn Asn Ile Gly Phe Gly Asp Glu Glu Asp Tyr 
                565                 570                 575     


Ser Asp Thr Leu Thr Gln Thr Leu Lys Glu Trp Phe Glu Val Ser Lys 
            580                 585                 590         


Lys His Tyr Pro Asn Val Leu Val His His Asn Glu Val Gly Asn Thr 
        595                 600                 605             


Pro Pro Pro Thr Met Ser Leu Ile Ser Thr Phe Asn Glu Asn Met Leu 
    610                 615                 620                 


Arg Lys Tyr Met Arg Thr Ala Lys Pro Asp Phe Ile Thr Tyr Asp Met 
625                 630                 635                 640 


Tyr Tyr Phe Arg Glu Asn Arg Gln Ser Ser Glu Val Gly Gly Thr Val 
                645                 650                 655     


Ile Pro Phe Tyr Asp Asp Leu Asn Arg Tyr Arg Lys Val Ala Ser Glu 
            660                 665                 670         


Gly Tyr Asp Gly Ser Gly Leu Ser Pro Ile Pro Phe Gly Thr Tyr Leu 
        675                 680                 685             


Gln Gly Trp Arg Thr Gly Pro Gly Ala Ala Thr Tyr Glu Lys Arg Gly 
    690                 695                 700                 


Asp Gly Trp Tyr Glu Ile Thr Glu Ser Gln Ala Tyr Leu Ser Ala Phe 
705                 710                 715                 720 


Ala Asn Trp Thr Phe Gly Ala Lys Trp Leu Ser Met Phe Arg Trp Ile 
                725                 730                 735     


Glu Asp Thr Pro Gly Tyr Leu Phe Ser Asp Tyr Arg Pro Asp Glu Asp 
            740                 745                 750         


Gly Asn Trp Pro Lys Tyr His Ile Tyr Gly Gln Tyr Lys Glu Met Phe 
        755                 760                 765             


Arg Gln Ser Lys Asn Leu Gly Glu His Leu Ile Arg Ile Asn Asn Lys 
    770                 775                 780                 


Asp Val Val Ile Val Pro Gly Gln His Met Lys Asp Gly Gln Ile Thr 
785                 790                 795                 800 


Lys Asn Asn Arg Pro Lys Asp Asn Pro Glu Trp Thr Lys Ser Gly Asp 
                805                 810                 815     


Arg Ala Phe Ile Asp Ser Leu Glu Ile Ser Asn Leu Gly Lys Thr Asn 
            820                 825                 830         


His Ser Leu Lys Gly Asp Val Phe Ile Gly Tyr Phe Asp Pro Leu Pro 
        835                 840                 845             


Gly Ile Asp Thr Thr Gln Phe Phe Thr Ser Thr Ala Pro Lys Tyr Phe 
    850                 855                 860                 


Met Leu Leu Asn Gly Leu Thr Ser Gly Gln Gly Leu Pro Ala Glu Glu 
865                 870                 875                 880 


Gln Thr Gly Ser Ser Tyr Glu Thr Arg Gln Glu Ile Lys Val Thr Phe 
                885                 890                 895     


Asp Leu Ser Gly Gly Gln Ala Arg Ala Asp Gln Leu Arg Lys Val Ser 
            900                 905                 910         


Arg Leu Thr Gly Glu Leu Val Ala Ala Pro Leu Lys Asp Leu Gly Asn 
        915                 920                 925             


Gly Lys Tyr Glu Met Thr Val Val Leu Gly Gly Gly Met Ala Asp Leu 
    930                 935                 940                 


Tyr Phe Trp Glu Leu Gly Ser Leu Asn Thr Gly Asn Ser Lys Pro Val 
945                 950                 955                 960 


Val Ala Asp Thr Pro His Asp Val Arg Leu Thr Gly Asp Pro Lys Tyr 
                965                 970                 975     


Ala Lys Asn Arg Glu Ile Arg Asp Leu Thr Gly Lys Thr Val Thr Val 
            980                 985                 990         


Gly Trp Ile Lys Asp Thr Tyr Ser  Pro Val Pro Gln Pro  Leu Ile His 
        995                 1000                 1005             


Tyr Asn  Phe Ser Phe Thr Lys  Asp Gln Asn Gly Lys  Leu Gln Pro 
    1010                 1015                 1020             


Met Lys  Asn Pro Asp Ile Leu  Ser Tyr Phe Thr Arg  Tyr Tyr Glu 
    1025                 1030                 1035             


Asn Thr  Leu Trp Asn Lys Arg  Val Glu Arg Ile Gln  Lys Glu Ser 
    1040                 1045                 1050             


Asn Val  Lys Leu Glu Phe Val  Ala Asp Ile Ala Trp  Thr Lys Gln 
    1055                 1060                 1065             


Glu Leu  Met Asp Asn Ile Arg  Lys Val Lys Glu Gly  Gln Thr Val 
    1070                 1075                 1080             


Asp Gly  Met Pro Asp Ile Leu  Ile Val Pro Asp Glu  Trp Thr Trp 
    1085                 1090                 1095             


Ser Gly  Leu Ile Gln Asn Glu  Met Ile Leu Pro Ala  Ser Ser Phe 
    1100                 1105                 1110             


Ser Glu  Phe Asp Phe Thr Glu  Arg Lys Trp Asn Lys  Ser Tyr Lys 
    1115                 1120                 1125             


Ala Met  Thr Thr Trp Lys Asp  Gln Ile Tyr Gly Met  Tyr Ala Gly 
    1130                 1135                 1140             


Pro Thr  Met Asn Ser Thr Gly  Leu Phe Val Asn Lys  Ala Leu Gln 
    1145                 1150                 1155             


Ala Ser  Ile Gly Val Thr Asp  Asp Leu Met Ala Leu  Gln Gln Asn 
    1160                 1165                 1170             


Asn Ala  Trp Asp Trp Asn Lys  Leu Arg Glu Val Ala  Ser Ala Phe 
    1175                 1180                 1185             


Gln Ala  Ser Ala Asn Arg Glu  Gly Lys Tyr Leu Leu  Ala Gly Thr 
    1190                 1195                 1200             


Asp Glu  Leu Phe Lys Gln Met  Val Tyr Ala Asn Gly  Ala Ala Arg 
    1205                 1210                 1215             


Gly Ser  Val Gly Gly Ala Met  Asn Gln Glu Phe Asp  Leu Thr Ser 
    1220                 1225                 1230             


Ser Ser  Phe Arg Glu Ala Ala  Glu Leu Tyr Ser Glu  Leu His Ala 
    1235                 1240                 1245             


Ala Gly  Leu Ile Ala Ala Lys  Pro Glu Gly Ala Thr  Asp Asp Trp 
    1250                 1255                 1260             


Tyr Val  Glu Gln Phe Ser Lys  Asn Asn Ile Leu Phe  Leu Ala Leu 
    1265                 1270                 1275             


Pro Tyr  Gln Gln Thr Val Asp  Lys Leu Lys Phe Ser  Tyr Thr Asn 
    1280                 1285                 1290             


Gln Asp  Ala Val Ile Glu Met  Lys Glu Gly Ser Phe  Leu Gly Gln 
    1295                 1300                 1305             


Pro Ala  Leu Ile Pro Thr Ile  Val Asp Ala Tyr Glu  Thr Ala Tyr 
    1310                 1315                 1320             


Pro Asp  Gly Ile Tyr Lys Met  Ala Gln Gly Asp Trp  Val Phe Leu 
    1325                 1330                 1335             


Met Phe  Pro Lys Gly Pro Ser  Ala Thr Gly Tyr Ala  Ala Met Ile 
    1340                 1345                 1350             


Asp Asn  Pro Ala Tyr Pro Val  Leu Leu Ser Ser Ser  Ala Asn Pro 
    1355                 1360                 1365             


Ala Asp  Ala Ala Tyr Val Trp  Asn Ile Leu Ser His  Glu Phe Glu 
    1370                 1375                 1380             


Gly Val  Ala Tyr Asp Arg Phe  Leu Lys Leu Tyr Leu  Asn Gln Arg 
    1385                 1390                 1395             


Glu Val  Asp Lys Thr Thr Leu  Lys Arg Ile Gly Leu  Lys Glu Gly 
    1400                 1405                 1410             


Val Trp  Asp Ser Tyr Ser Gly  Thr Gly Ala Trp Glu  Gln Val Ile 
    1415                 1420                 1425             


Lys Pro  Gly Val Leu Pro Met  Leu Gln Ala Gly Val  Ile Asp Glu 
    1430                 1435                 1440             


Ala Lys  Leu Ala Glu Leu Ser  Val Glu Ala Ala Ser  Tyr Val Thr 
    1445                 1450                 1455             


Asn Asn  Met Thr Lys Pro Ala  Gln Pro Gly 
    1460                 1465             


<210> 3
<211> 1356
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Ser Ile Arg Gln Asp Pro Thr Thr Gly Asn Tyr Tyr Lys Asn Val Pro 
1               5                   10                  15      


Leu Val Gly Ala Asp Phe Asp Asp Ala Ser Asn Ser Asn Ile Val Ala 
            20                  25                  30          


Lys Gly Thr Trp Asp Asp Asn Thr Ala Pro Leu Asn Thr Phe Tyr Pro 
        35                  40                  45              


His Ala Lys Ile Phe Phe Trp Gly Ser Asn Asn Leu Pro Lys Val Leu 
    50                  55                  60                  


Val Asp Lys Leu Arg Leu Glu Lys Val Leu Glu His Pro Gly Pro Ala 
65                  70                  75                  80  


Ala Pro Ala Val Thr Ala Asp Asp Val Asn Asn Ile Val Val Gly Ile 
                85                  90                  95      


Asp Glu Thr Met Glu Tyr Asn Ile Asn Gly Ala Gly Trp Val Ala Tyr 
            100                 105                 110         


Lys Glu Tyr Ala Lys Pro Asp Leu Lys Gly Asp Leu Ile Val Gln Ile 
        115                 120                 125             


Arg Val Lys Glu Thr Leu Asn Thr Leu Ala Gly Glu Val Thr Thr Leu 
    130                 135                 140                 


Thr Phe Thr Ala Gln Asn Asp Pro Ala Pro Gly Gln Pro Glu Gln Leu 
145                 150                 155                 160 


Leu Leu Lys Asp Gly Asp Phe Glu Ala Gly Ala Ala Ser Val Thr Thr 
                165                 170                 175     


Asp Thr Asn Val Gln Asn Gln Phe Phe Ser Lys Asn Asn Gln Tyr Glu 
            180                 185                 190         


Ile Val Thr Gly Asp Thr Ala Ser Gly Gln Tyr Ala Leu Lys Leu Arg 
        195                 200                 205             


Ser Pro Glu Thr Ile Gly Tyr His Lys Thr Asp Leu Lys Pro Ser Thr 
    210                 215                 220                 


Lys Tyr Gln Ile Ser Phe Met Ala Lys Val Gly Ser Ala Ser Gln Lys 
225                 230                 235                 240 


Leu Ser Phe Arg Ile Ser Gly Tyr Lys Asn Asp Asn Pro Tyr Asp Leu 
                245                 250                 255     


Asp Asn Val Met Asn Tyr Ile Glu His Thr Gln Met Lys Asn Thr Gly 
            260                 265                 270         


Trp Ser Arg Phe Tyr Tyr Asp Leu Glu Thr Gly Pro Ser Ala Thr Ser 
        275                 280                 285             


Ala Phe Ile Asp Phe Ser Thr Ala Ala Gly Ser Thr Ala Trp Ile Asp 
    290                 295                 300                 


Asp Val Lys Leu Val Glu Gln Gly Pro Ala Asp Pro Pro Val Thr Glu 
305                 310                 315                 320 


Pro Thr Leu Ser Arg Gly Ser Arg Leu Phe Leu Glu Lys Gly Leu Gln 
                325                 330                 335     


Ile Gln Ser Trp Val Pro Thr Asp Val Ala Tyr Ala Thr Arg Lys Trp 
            340                 345                 350         


Met Lys Pro Pro Thr Ala Glu Glu Ile Val Asp Leu Gly Leu Thr Thr 
        355                 360                 365             


Val Gln Tyr Asn Asp Ala Pro Asn Tyr Ser Lys Thr Leu His Glu Glu 
    370                 375                 380                 


Tyr Lys Lys Leu Gln Gln Thr Asn Pro Ser Leu Pro Asp Leu Lys Trp 
385                 390                 395                 400 


Gly Val Ala Phe Gly Pro Asn Ala Asn His Leu Ser Ser Ser Tyr Phe 
                405                 410                 415     


Asp Ser Glu Thr Ile Ala Lys His Asp Pro Asn Lys Thr Gly Ala Pro 
            420                 425                 430         


Thr Glu Glu Gln Lys Ala Arg Gly Phe Leu Thr Pro Asp Gln Leu Ala 
        435                 440                 445             


Asn Val Gln Asn Leu Asn Asn Ile Gly Phe Gly Asp Glu Glu Asp Tyr 
    450                 455                 460                 


Ser Asp Thr Leu Thr Gln Thr Leu Lys Glu Trp Phe Glu Val Ser Lys 
465                 470                 475                 480 


Lys His Tyr Pro Asn Val Leu Val His His Asn Glu Val Gly Asn Thr 
                485                 490                 495     


Pro Pro Pro Thr Met Ser Leu Ile Ser Thr Phe Asn Glu Asn Met Leu 
            500                 505                 510         


Arg Lys Tyr Met Arg Thr Ala Lys Pro Asp Phe Ile Thr Tyr Asp Met 
        515                 520                 525             


Tyr Tyr Phe Arg Glu Asn Arg Gln Ser Ser Glu Val Gly Gly Thr Val 
    530                 535                 540                 


Ile Pro Phe Tyr Asp Asp Leu Asn Arg Tyr Arg Lys Val Ala Ser Glu 
545                 550                 555                 560 


Gly Tyr Asp Gly Ser Gly Leu Ser Pro Ile Pro Phe Gly Thr Tyr Leu 
                565                 570                 575     


Gln Gly Trp Arg Thr Gly Pro Gly Ala Ala Thr Tyr Glu Lys Arg Gly 
            580                 585                 590         


Asp Gly Trp Tyr Glu Ile Thr Glu Ser Gln Ala Tyr Leu Ser Ala Phe 
        595                 600                 605             


Ala Asn Trp Thr Phe Gly Ala Lys Trp Leu Ser Met Phe Arg Trp Ile 
    610                 615                 620                 


Glu Asp Thr Pro Gly Tyr Leu Phe Ser Asp Tyr Arg Pro Asp Glu Asp 
625                 630                 635                 640 


Gly Asn Trp Pro Lys Tyr His Ile Tyr Gly Gln Tyr Lys Glu Met Phe 
                645                 650                 655     


Arg Gln Ser Lys Asn Leu Gly Glu His Leu Ile Arg Ile Asn Asn Lys 
            660                 665                 670         


Asp Val Val Ile Val Pro Gly Gln His Met Lys Asp Gly Gln Ile Thr 
        675                 680                 685             


Lys Asn Asn Arg Pro Lys Asp Asn Pro Glu Trp Thr Lys Ser Gly Asp 
    690                 695                 700                 


Arg Ala Phe Ile Asp Ser Leu Glu Ile Ser Asn Leu Gly Lys Thr Asn 
705                 710                 715                 720 


His Ser Leu Lys Gly Asp Val Phe Ile Gly Tyr Phe Asp Pro Leu Pro 
                725                 730                 735     


Gly Ile Asp Thr Thr Gln Phe Phe Thr Ser Thr Ala Pro Lys Tyr Phe 
            740                 745                 750         


Met Leu Leu Asn Gly Leu Thr Ser Gly Gln Gly Leu Pro Ala Glu Glu 
        755                 760                 765             


Gln Thr Gly Ser Ser Tyr Glu Thr Arg Gln Glu Ile Lys Val Thr Phe 
    770                 775                 780                 


Asp Leu Ser Gly Gly Gln Ala Arg Ala Asp Gln Leu Arg Lys Val Ser 
785                 790                 795                 800 


Arg Leu Thr Gly Glu Leu Val Ala Ala Pro Leu Lys Asp Leu Gly Asn 
                805                 810                 815     


Gly Lys Tyr Glu Met Thr Val Val Leu Gly Gly Gly Met Ala Asp Leu 
            820                 825                 830         


Tyr Phe Trp Glu Leu Gly Ser Leu Asn Thr Gly Asn Ser Lys Pro Val 
        835                 840                 845             


Val Ala Asp Thr Pro His Asp Val Arg Leu Thr Gly Asp Pro Lys Tyr 
    850                 855                 860                 


Ala Lys Asn Arg Glu Ile Arg Asp Leu Thr Gly Lys Thr Val Thr Val 
865                 870                 875                 880 


Gly Trp Ile Lys Asp Thr Tyr Ser Pro Val Pro Gln Pro Leu Ile His 
                885                 890                 895     


Tyr Asn Phe Ser Phe Thr Lys Asp Gln Asn Gly Lys Leu Gln Pro Met 
            900                 905                 910         


Lys Asn Pro Asp Ile Leu Ser Tyr Phe Thr Arg Tyr Tyr Glu Asn Thr 
        915                 920                 925             


Leu Trp Asn Lys Arg Val Glu Arg Ile Gln Lys Glu Ser Asn Val Lys 
    930                 935                 940                 


Leu Glu Phe Val Ala Asp Ile Ala Trp Thr Lys Gln Glu Leu Met Asp 
945                 950                 955                 960 


Asn Ile Arg Lys Val Lys Glu Gly Gln Thr Val Asp Gly Met Pro Asp 
                965                 970                 975     


Ile Leu Ile Val Pro Asp Glu Trp Thr Trp Ser Gly Leu Ile Gln Asn 
            980                 985                 990         


Glu Met Ile Leu Pro Ala Ser Ser  Phe Ser Glu Phe Asp  Phe Thr Glu 
        995                 1000                 1005             


Arg Lys  Trp Asn Lys Ser Tyr  Lys Ala Met Thr Thr  Trp Lys Asp 
    1010                 1015                 1020             


Gln Ile  Tyr Gly Met Tyr Ala  Gly Pro Thr Met Asn  Ser Thr Gly 
    1025                 1030                 1035             


Leu Phe  Val Asn Lys Ala Leu  Gln Ala Ser Ile Gly  Val Thr Asp 
    1040                 1045                 1050             


Asp Leu  Met Ala Leu Gln Gln  Asn Asn Ala Trp Asp  Trp Asn Lys 
    1055                 1060                 1065             


Leu Arg  Glu Val Ala Ser Ala  Phe Gln Ala Ser Ala  Asn Arg Glu 
    1070                 1075                 1080             


Gly Lys  Tyr Leu Leu Ala Gly  Thr Asp Glu Leu Phe  Lys Gln Met 
    1085                 1090                 1095             


Val Tyr  Ala Asn Gly Ala Ala  Arg Gly Ser Val Gly  Gly Ala Met 
    1100                 1105                 1110             


Asn Gln  Glu Phe Asp Leu Thr  Ser Ser Ser Phe Arg  Glu Ala Ala 
    1115                 1120                 1125             


Glu Leu  Tyr Ser Glu Leu His  Ala Ala Gly Leu Ile  Ala Ala Lys 
    1130                 1135                 1140             


Pro Glu  Gly Ala Thr Asp Asp  Trp Tyr Val Glu Gln  Phe Ser Lys 
    1145                 1150                 1155             


Asn Asn  Ile Leu Phe Leu Ala  Leu Pro Tyr Gln Gln  Thr Val Asp 
    1160                 1165                 1170             


Lys Leu  Lys Phe Ser Tyr Thr  Asn Gln Asp Ala Val  Ile Glu Met 
    1175                 1180                 1185             


Lys Glu  Gly Ser Phe Leu Gly  Gln Pro Ala Leu Ile  Pro Thr Ile 
    1190                 1195                 1200             


Val Asp  Ala Tyr Glu Thr Ala  Tyr Pro Asp Gly Ile  Tyr Lys Met 
    1205                 1210                 1215             


Ala Gln  Gly Asp Trp Val Phe  Leu Met Phe Pro Lys  Gly Pro Ser 
    1220                 1225                 1230             


Ala Thr  Gly Tyr Ala Ala Met  Ile Asp Asn Pro Ala  Tyr Pro Val 
    1235                 1240                 1245             


Leu Leu  Ser Ser Ser Ala Asn  Pro Ala Asp Ala Ala  Tyr Val Trp 
    1250                 1255                 1260             


Asn Ile  Leu Ser His Glu Phe  Glu Gly Val Ala Tyr  Asp Arg Phe 
    1265                 1270                 1275             


Leu Lys  Leu Tyr Leu Asn Gln  Arg Glu Val Asp Lys  Thr Thr Leu 
    1280                 1285                 1290             


Lys Arg  Ile Gly Leu Lys Glu  Gly Val Trp Asp Ser  Tyr Ser Gly 
    1295                 1300                 1305             


Thr Gly  Ala Trp Glu Gln Val  Ile Lys Pro Gly Val  Leu Pro Met 
    1310                 1315                 1320             


Leu Gln  Ala Gly Val Ile Asp  Glu Ala Lys Leu Ala  Glu Leu Ser 
    1325                 1330                 1335             


Val Glu  Ala Ala Ser Tyr Val  Thr Asn Asn Met Thr  Lys Pro Ala 
    1340                 1345                 1350             


Gln Pro  Gly 
    1355     


<210> 4
<211> 1400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Ser Ile Arg Gln Asp Pro Thr Thr Gly Asn Tyr Tyr Lys Asn Val Pro 
1               5                   10                  15      


Leu Val Gly Ala Asp Phe Asp Asp Ala Ser Asn Ser Asn Ile Val Ala 
            20                  25                  30          


Lys Gly Thr Trp Asp Asp Asn Thr Ala Pro Leu Asn Thr Phe Phe Val 
        35                  40                  45              


Asp Lys Gly Thr Ala Thr Asp Gly Gly Phe Thr Thr Ala Arg Ile Thr 
    50                  55                  60                  


Thr Val Thr Asp Gln Val Tyr Glu Gly Gly Ser Leu Gln Phe Gly Asp 
65                  70                  75                  80  


Gly Ser Thr Tyr Pro Ile Asn Leu Asn Tyr Lys Val Asp Gly Leu Glu 
                85                  90                  95      


Val Gly Ala Thr Tyr Arg Leu Ser Ala Tyr Met Lys Leu Phe Pro Gly 
            100                 105                 110         


Tyr Pro Ala Lys Gly Gly Gln Phe Gly Val Lys Asn His Asp Thr Ala 
        115                 120                 125             


Asn Tyr Thr Thr Gly Gly Glu Thr Lys Ser Val Asn Phe Ser Thr Val 
    130                 135                 140                 


Thr Ala Asp Trp Lys Glu Tyr Ser Val Thr Phe Thr Pro Thr Tyr Pro 
145                 150                 155                 160 


His Ala Lys Ile Phe Phe Trp Gly Ser Asn Asn Leu Pro Lys Val Leu 
                165                 170                 175     


Val Asp Lys Leu Arg Leu Glu Lys Val Leu Glu His Pro Gly Pro Ala 
            180                 185                 190         


Gln Asn Asp Pro Ala Pro Gly Gln Pro Glu Gln Leu Leu Leu Lys Asp 
        195                 200                 205             


Gly Asp Phe Glu Ala Gly Ala Ala Ser Val Thr Thr Asp Thr Asn Val 
    210                 215                 220                 


Gln Asn Gln Phe Phe Ser Lys Asn Asn Gln Tyr Glu Ile Val Thr Gly 
225                 230                 235                 240 


Asp Thr Ala Ser Gly Gln Tyr Ala Leu Lys Leu Arg Ser Pro Glu Thr 
                245                 250                 255     


Ile Gly Tyr His Lys Thr Asp Leu Lys Pro Ser Thr Lys Tyr Gln Ile 
            260                 265                 270         


Ser Phe Met Ala Lys Val Gly Ser Ala Ser Gln Lys Leu Ser Phe Arg 
        275                 280                 285             


Ile Ser Gly Tyr Lys Asn Asp Asn Pro Tyr Asp Leu Asp Asn Val Met 
    290                 295                 300                 


Asn Tyr Ile Glu His Thr Gln Met Lys Asn Thr Gly Trp Ser Arg Phe 
305                 310                 315                 320 


Tyr Tyr Asp Leu Glu Thr Gly Pro Ser Ala Thr Ser Ala Phe Ile Asp 
                325                 330                 335     


Phe Ser Thr Ala Ala Gly Ser Thr Ala Trp Ile Asp Asp Val Lys Leu 
            340                 345                 350         


Val Glu Gln Gly Pro Ala Asp Pro Pro Val Thr Glu Pro Thr Leu Ser 
        355                 360                 365             


Arg Gly Ser Arg Leu Phe Leu Glu Lys Gly Leu Gln Ile Gln Ser Trp 
    370                 375                 380                 


Val Pro Thr Asp Val Ala Tyr Ala Thr Arg Lys Trp Met Lys Pro Pro 
385                 390                 395                 400 


Thr Ala Glu Glu Ile Val Asp Leu Gly Leu Thr Thr Val Gln Tyr Asn 
                405                 410                 415     


Asp Ala Pro Asn Tyr Ser Lys Thr Leu His Glu Glu Tyr Lys Lys Leu 
            420                 425                 430         


Gln Gln Thr Asn Pro Ser Leu Pro Asp Leu Lys Trp Gly Val Ala Phe 
        435                 440                 445             


Gly Pro Asn Ala Asn His Leu Ser Ser Ser Tyr Phe Asp Ser Glu Thr 
    450                 455                 460                 


Ile Ala Lys His Asp Pro Asn Lys Thr Gly Ala Pro Thr Glu Glu Gln 
465                 470                 475                 480 


Lys Ala Arg Gly Phe Leu Thr Pro Asp Gln Leu Ala Asn Val Gln Asn 
                485                 490                 495     


Leu Asn Asn Ile Gly Phe Gly Asp Glu Glu Asp Tyr Ser Asp Thr Leu 
            500                 505                 510         


Thr Gln Thr Leu Lys Glu Trp Phe Glu Val Ser Lys Lys His Tyr Pro 
        515                 520                 525             


Asn Val Leu Val His His Asn Glu Val Gly Asn Thr Pro Pro Pro Thr 
    530                 535                 540                 


Met Ser Leu Ile Ser Thr Phe Asn Glu Asn Met Leu Arg Lys Tyr Met 
545                 550                 555                 560 


Arg Thr Ala Lys Pro Asp Phe Ile Thr Tyr Asp Met Tyr Tyr Phe Arg 
                565                 570                 575     


Glu Asn Arg Gln Ser Ser Glu Val Gly Gly Thr Val Ile Pro Phe Tyr 
            580                 585                 590         


Asp Asp Leu Asn Arg Tyr Arg Lys Val Ala Ser Glu Gly Tyr Asp Gly 
        595                 600                 605             


Ser Gly Leu Ser Pro Ile Pro Phe Gly Thr Tyr Leu Gln Gly Trp Arg 
    610                 615                 620                 


Thr Gly Pro Gly Ala Ala Thr Tyr Glu Lys Arg Gly Asp Gly Trp Tyr 
625                 630                 635                 640 


Glu Ile Thr Glu Ser Gln Ala Tyr Leu Ser Ala Phe Ala Asn Trp Thr 
                645                 650                 655     


Phe Gly Ala Lys Trp Leu Ser Met Phe Arg Trp Ile Glu Asp Thr Pro 
            660                 665                 670         


Gly Tyr Leu Phe Ser Asp Tyr Arg Pro Asp Glu Asp Gly Asn Trp Pro 
        675                 680                 685             


Lys Tyr His Ile Tyr Gly Gln Tyr Lys Glu Met Phe Arg Gln Ser Lys 
    690                 695                 700                 


Asn Leu Gly Glu His Leu Ile Arg Ile Asn Asn Lys Asp Val Val Ile 
705                 710                 715                 720 


Val Pro Gly Gln His Met Lys Asp Gly Gln Ile Thr Lys Asn Asn Arg 
                725                 730                 735     


Pro Lys Asp Asn Pro Glu Trp Thr Lys Ser Gly Asp Arg Ala Phe Ile 
            740                 745                 750         


Asp Ser Leu Glu Ile Ser Asn Leu Gly Lys Thr Asn His Ser Leu Lys 
        755                 760                 765             


Gly Asp Val Phe Ile Gly Tyr Phe Asp Pro Leu Pro Gly Ile Asp Thr 
    770                 775                 780                 


Thr Gln Phe Phe Thr Ser Thr Ala Pro Lys Tyr Phe Met Leu Leu Asn 
785                 790                 795                 800 


Gly Leu Thr Ser Gly Gln Gly Leu Pro Ala Glu Glu Gln Thr Gly Ser 
                805                 810                 815     


Ser Tyr Glu Thr Arg Gln Glu Ile Lys Val Thr Phe Asp Leu Ser Gly 
            820                 825                 830         


Gly Gln Ala Arg Ala Asp Gln Leu Arg Lys Val Ser Arg Leu Thr Gly 
        835                 840                 845             


Glu Leu Val Ala Ala Pro Leu Lys Asp Leu Gly Asn Gly Lys Tyr Glu 
    850                 855                 860                 


Met Thr Val Val Leu Gly Gly Gly Met Ala Asp Leu Tyr Phe Trp Glu 
865                 870                 875                 880 


Leu Gly Ser Leu Asn Thr Gly Asn Ser Lys Pro Val Val Ala Asp Thr 
                885                 890                 895     


Pro His Asp Val Arg Leu Thr Gly Asp Pro Lys Tyr Ala Lys Asn Arg 
            900                 905                 910         


Glu Ile Arg Asp Leu Thr Gly Lys Thr Val Thr Val Gly Trp Ile Lys 
        915                 920                 925             


Asp Thr Tyr Ser Pro Val Pro Gln Pro Leu Ile His Tyr Asn Phe Ser 
    930                 935                 940                 


Phe Thr Lys Asp Gln Asn Gly Lys Leu Gln Pro Met Lys Asn Pro Asp 
945                 950                 955                 960 


Ile Leu Ser Tyr Phe Thr Arg Tyr Tyr Glu Asn Thr Leu Trp Asn Lys 
                965                 970                 975     


Arg Val Glu Arg Ile Gln Lys Glu Ser Asn Val Lys Leu Glu Phe Val 
            980                 985                 990         


Ala Asp Ile Ala Trp Thr Lys Gln  Glu Leu Met Asp Asn  Ile Arg Lys 
        995                 1000                 1005             


Val Lys  Glu Gly Gln Thr Val  Asp Gly Met Pro Asp  Ile Leu Ile 
    1010                 1015                 1020             


Val Pro  Asp Glu Trp Thr Trp  Ser Gly Leu Ile Gln  Asn Glu Met 
    1025                 1030                 1035             


Ile Leu  Pro Ala Ser Ser Phe  Ser Glu Phe Asp Phe  Thr Glu Arg 
    1040                 1045                 1050             


Lys Trp  Asn Lys Ser Tyr Lys  Ala Met Thr Thr Trp  Lys Asp Gln 
    1055                 1060                 1065             


Ile Tyr  Gly Met Tyr Ala Gly  Pro Thr Met Asn Ser  Thr Gly Leu 
    1070                 1075                 1080             


Phe Val  Asn Lys Ala Leu Gln  Ala Ser Ile Gly Val  Thr Asp Asp 
    1085                 1090                 1095             


Leu Met  Ala Leu Gln Gln Asn  Asn Ala Trp Asp Trp  Asn Lys Leu 
    1100                 1105                 1110             


Arg Glu  Val Ala Ser Ala Phe  Gln Ala Ser Ala Asn  Arg Glu Gly 
    1115                 1120                 1125             


Lys Tyr  Leu Leu Ala Gly Thr  Asp Glu Leu Phe Lys  Gln Met Val 
    1130                 1135                 1140             


Tyr Ala  Asn Gly Ala Ala Arg  Gly Ser Val Gly Gly  Ala Met Asn 
    1145                 1150                 1155             


Gln Glu  Phe Asp Leu Thr Ser  Ser Ser Phe Arg Glu  Ala Ala Glu 
    1160                 1165                 1170             


Leu Tyr  Ser Glu Leu His Ala  Ala Gly Leu Ile Ala  Ala Lys Pro 
    1175                 1180                 1185             


Glu Gly  Ala Thr Asp Asp Trp  Tyr Val Glu Gln Phe  Ser Lys Asn 
    1190                 1195                 1200             


Asn Ile  Leu Phe Leu Ala Leu  Pro Tyr Gln Gln Thr  Val Asp Lys 
    1205                 1210                 1215             


Leu Lys  Phe Ser Tyr Thr Asn  Gln Asp Ala Val Ile  Glu Met Lys 
    1220                 1225                 1230             


Glu Gly  Ser Phe Leu Gly Gln  Pro Ala Leu Ile Pro  Thr Ile Val 
    1235                 1240                 1245             


Asp Ala  Tyr Glu Thr Ala Tyr  Pro Asp Gly Ile Tyr  Lys Met Ala 
    1250                 1255                 1260             


Gln Gly  Asp Trp Val Phe Leu  Met Phe Pro Lys Gly  Pro Ser Ala 
    1265                 1270                 1275             


Thr Gly  Tyr Ala Ala Met Ile  Asp Asn Pro Ala Tyr  Pro Val Leu 
    1280                 1285                 1290             


Leu Ser  Ser Ser Ala Asn Pro  Ala Asp Ala Ala Tyr  Val Trp Asn 
    1295                 1300                 1305             


Ile Leu  Ser His Glu Phe Glu  Gly Val Ala Tyr Asp  Arg Phe Leu 
    1310                 1315                 1320             


Lys Leu  Tyr Leu Asn Gln Arg  Glu Val Asp Lys Thr  Thr Leu Lys 
    1325                 1330                 1335             


Arg Ile  Gly Leu Lys Glu Gly  Val Trp Asp Ser Tyr  Ser Gly Thr 
    1340                 1345                 1350             


Gly Ala  Trp Glu Gln Val Ile  Lys Pro Gly Val Leu  Pro Met Leu 
    1355                 1360                 1365             


Gln Ala  Gly Val Ile Asp Glu  Ala Lys Leu Ala Glu  Leu Ser Val 
    1370                 1375                 1380             


Glu Ala  Ala Ser Tyr Val Thr  Asn Asn Met Thr Lys  Pro Ala Gln 
    1385                 1390                 1395             


Pro Gly  
    1400 


<210> 5
<211> 1254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Ser Ile Arg Gln Asp Pro Thr Thr Gly Asn Tyr Tyr Lys Asn Val Pro 
1               5                   10                  15      


Leu Val Gly Ala Asp Phe Asp Asp Ala Ser Asn Ser Asn Ile Val Ala 
            20                  25                  30          


Lys Gly Thr Trp Asp Asp Asn Thr Ala Pro Leu Asn Thr Phe Gln Asn 
        35                  40                  45              


Asp Pro Ala Pro Gly Gln Pro Glu Gln Leu Leu Leu Lys Asp Gly Asp 
    50                  55                  60                  


Phe Glu Ala Gly Ala Ala Ser Val Thr Thr Asp Thr Asn Val Gln Asn 
65                  70                  75                  80  


Gln Phe Phe Ser Lys Asn Asn Gln Tyr Glu Ile Val Thr Gly Asp Thr 
                85                  90                  95      


Ala Ser Gly Gln Tyr Ala Leu Lys Leu Arg Ser Pro Glu Thr Ile Gly 
            100                 105                 110         


Tyr His Lys Thr Asp Leu Lys Pro Ser Thr Lys Tyr Gln Ile Ser Phe 
        115                 120                 125             


Met Ala Lys Val Gly Ser Ala Ser Gln Lys Leu Ser Phe Arg Ile Ser 
    130                 135                 140                 


Gly Tyr Lys Asn Asp Asn Pro Tyr Asp Leu Asp Asn Val Met Asn Tyr 
145                 150                 155                 160 


Ile Glu His Thr Gln Met Lys Asn Thr Gly Trp Ser Arg Phe Tyr Tyr 
                165                 170                 175     


Asp Leu Glu Thr Gly Pro Ser Ala Thr Ser Ala Phe Ile Asp Phe Ser 
            180                 185                 190         


Thr Ala Ala Gly Ser Thr Ala Trp Ile Asp Asp Val Lys Leu Val Glu 
        195                 200                 205             


Gln Gly Pro Ala Asp Pro Pro Val Thr Glu Pro Thr Leu Ser Arg Gly 
    210                 215                 220                 


Ser Arg Leu Phe Leu Glu Lys Gly Leu Gln Ile Gln Ser Trp Val Pro 
225                 230                 235                 240 


Thr Asp Val Ala Tyr Ala Thr Arg Lys Trp Met Lys Pro Pro Thr Ala 
                245                 250                 255     


Glu Glu Ile Val Asp Leu Gly Leu Thr Thr Val Gln Tyr Asn Asp Ala 
            260                 265                 270         


Pro Asn Tyr Ser Lys Thr Leu His Glu Glu Tyr Lys Lys Leu Gln Gln 
        275                 280                 285             


Thr Asn Pro Ser Leu Pro Asp Leu Lys Trp Gly Val Ala Phe Gly Pro 
    290                 295                 300                 


Asn Ala Asn His Leu Ser Ser Ser Tyr Phe Asp Ser Glu Thr Ile Ala 
305                 310                 315                 320 


Lys His Asp Pro Asn Lys Thr Gly Ala Pro Thr Glu Glu Gln Lys Ala 
                325                 330                 335     


Arg Gly Phe Leu Thr Pro Asp Gln Leu Ala Asn Val Gln Asn Leu Asn 
            340                 345                 350         


Asn Ile Gly Phe Gly Asp Glu Glu Asp Tyr Ser Asp Thr Leu Thr Gln 
        355                 360                 365             


Thr Leu Lys Glu Trp Phe Glu Val Ser Lys Lys His Tyr Pro Asn Val 
    370                 375                 380                 


Leu Val His His Asn Glu Val Gly Asn Thr Pro Pro Pro Thr Met Ser 
385                 390                 395                 400 


Leu Ile Ser Thr Phe Asn Glu Asn Met Leu Arg Lys Tyr Met Arg Thr 
                405                 410                 415     


Ala Lys Pro Asp Phe Ile Thr Tyr Asp Met Tyr Tyr Phe Arg Glu Asn 
            420                 425                 430         


Arg Gln Ser Ser Glu Val Gly Gly Thr Val Ile Pro Phe Tyr Asp Asp 
        435                 440                 445             


Leu Asn Arg Tyr Arg Lys Val Ala Ser Glu Gly Tyr Asp Gly Ser Gly 
    450                 455                 460                 


Leu Ser Pro Ile Pro Phe Gly Thr Tyr Leu Gln Gly Trp Arg Thr Gly 
465                 470                 475                 480 


Pro Gly Ala Ala Thr Tyr Glu Lys Arg Gly Asp Gly Trp Tyr Glu Ile 
                485                 490                 495     


Thr Glu Ser Gln Ala Tyr Leu Ser Ala Phe Ala Asn Trp Thr Phe Gly 
            500                 505                 510         


Ala Lys Trp Leu Ser Met Phe Arg Trp Ile Glu Asp Thr Pro Gly Tyr 
        515                 520                 525             


Leu Phe Ser Asp Tyr Arg Pro Asp Glu Asp Gly Asn Trp Pro Lys Tyr 
    530                 535                 540                 


His Ile Tyr Gly Gln Tyr Lys Glu Met Phe Arg Gln Ser Lys Asn Leu 
545                 550                 555                 560 


Gly Glu His Leu Ile Arg Ile Asn Asn Lys Asp Val Val Ile Val Pro 
                565                 570                 575     


Gly Gln His Met Lys Asp Gly Gln Ile Thr Lys Asn Asn Arg Pro Lys 
            580                 585                 590         


Asp Asn Pro Glu Trp Thr Lys Ser Gly Asp Arg Ala Phe Ile Asp Ser 
        595                 600                 605             


Leu Glu Ile Ser Asn Leu Gly Lys Thr Asn His Ser Leu Lys Gly Asp 
    610                 615                 620                 


Val Phe Ile Gly Tyr Phe Asp Pro Leu Pro Gly Ile Asp Thr Thr Gln 
625                 630                 635                 640 


Phe Phe Thr Ser Thr Ala Pro Lys Tyr Phe Met Leu Leu Asn Gly Leu 
                645                 650                 655     


Thr Ser Gly Gln Gly Leu Pro Ala Glu Glu Gln Thr Gly Ser Ser Tyr 
            660                 665                 670         


Glu Thr Arg Gln Glu Ile Lys Val Thr Phe Asp Leu Ser Gly Gly Gln 
        675                 680                 685             


Ala Arg Ala Asp Gln Leu Arg Lys Val Ser Arg Leu Thr Gly Glu Leu 
    690                 695                 700                 


Val Ala Ala Pro Leu Lys Asp Leu Gly Asn Gly Lys Tyr Glu Met Thr 
705                 710                 715                 720 


Val Val Leu Gly Gly Gly Met Ala Asp Leu Tyr Phe Trp Glu Leu Gly 
                725                 730                 735     


Ser Leu Asn Thr Gly Asn Ser Lys Pro Val Val Ala Asp Thr Pro His 
            740                 745                 750         


Asp Val Arg Leu Thr Gly Asp Pro Lys Tyr Ala Lys Asn Arg Glu Ile 
        755                 760                 765             


Arg Asp Leu Thr Gly Lys Thr Val Thr Val Gly Trp Ile Lys Asp Thr 
    770                 775                 780                 


Tyr Ser Pro Val Pro Gln Pro Leu Ile His Tyr Asn Phe Ser Phe Thr 
785                 790                 795                 800 


Lys Asp Gln Asn Gly Lys Leu Gln Pro Met Lys Asn Pro Asp Ile Leu 
                805                 810                 815     


Ser Tyr Phe Thr Arg Tyr Tyr Glu Asn Thr Leu Trp Asn Lys Arg Val 
            820                 825                 830         


Glu Arg Ile Gln Lys Glu Ser Asn Val Lys Leu Glu Phe Val Ala Asp 
        835                 840                 845             


Ile Ala Trp Thr Lys Gln Glu Leu Met Asp Asn Ile Arg Lys Val Lys 
    850                 855                 860                 


Glu Gly Gln Thr Val Asp Gly Met Pro Asp Ile Leu Ile Val Pro Asp 
865                 870                 875                 880 


Glu Trp Thr Trp Ser Gly Leu Ile Gln Asn Glu Met Ile Leu Pro Ala 
                885                 890                 895     


Ser Ser Phe Ser Glu Phe Asp Phe Thr Glu Arg Lys Trp Asn Lys Ser 
            900                 905                 910         


Tyr Lys Ala Met Thr Thr Trp Lys Asp Gln Ile Tyr Gly Met Tyr Ala 
        915                 920                 925             


Gly Pro Thr Met Asn Ser Thr Gly Leu Phe Val Asn Lys Ala Leu Gln 
    930                 935                 940                 


Ala Ser Ile Gly Val Thr Asp Asp Leu Met Ala Leu Gln Gln Asn Asn 
945                 950                 955                 960 


Ala Trp Asp Trp Asn Lys Leu Arg Glu Val Ala Ser Ala Phe Gln Ala 
                965                 970                 975     


Ser Ala Asn Arg Glu Gly Lys Tyr Leu Leu Ala Gly Thr Asp Glu Leu 
            980                 985                 990         


Phe Lys Gln Met Val Tyr Ala Asn  Gly Ala Ala Arg Gly  Ser Val Gly 
        995                 1000                 1005             


Gly Ala  Met Asn Gln Glu Phe  Asp Leu Thr Ser Ser  Ser Phe Arg 
    1010                 1015                 1020             


Glu Ala  Ala Glu Leu Tyr Ser  Glu Leu His Ala Ala  Gly Leu Ile 
    1025                 1030                 1035             


Ala Ala  Lys Pro Glu Gly Ala  Thr Asp Asp Trp Tyr  Val Glu Gln 
    1040                 1045                 1050             


Phe Ser  Lys Asn Asn Ile Leu  Phe Leu Ala Leu Pro  Tyr Gln Gln 
    1055                 1060                 1065             


Thr Val  Asp Lys Leu Lys Phe  Ser Tyr Thr Asn Gln  Asp Ala Val 
    1070                 1075                 1080             


Ile Glu  Met Lys Glu Gly Ser  Phe Leu Gly Gln Pro  Ala Leu Ile 
    1085                 1090                 1095             


Pro Thr  Ile Val Asp Ala Tyr  Glu Thr Ala Tyr Pro  Asp Gly Ile 
    1100                 1105                 1110             


Tyr Lys  Met Ala Gln Gly Asp  Trp Val Phe Leu Met  Phe Pro Lys 
    1115                 1120                 1125             


Gly Pro  Ser Ala Thr Gly Tyr  Ala Ala Met Ile Asp  Asn Pro Ala 
    1130                 1135                 1140             


Tyr Pro  Val Leu Leu Ser Ser  Ser Ala Asn Pro Ala  Asp Ala Ala 
    1145                 1150                 1155             


Tyr Val  Trp Asn Ile Leu Ser  His Glu Phe Glu Gly  Val Ala Tyr 
    1160                 1165                 1170             


Asp Arg  Phe Leu Lys Leu Tyr  Leu Asn Gln Arg Glu  Val Asp Lys 
    1175                 1180                 1185             


Thr Thr  Leu Lys Arg Ile Gly  Leu Lys Glu Gly Val  Trp Asp Ser 
    1190                 1195                 1200             


Tyr Ser  Gly Thr Gly Ala Trp  Glu Gln Val Ile Lys  Pro Gly Val 
    1205                 1210                 1215             


Leu Pro  Met Leu Gln Ala Gly  Val Ile Asp Glu Ala  Lys Leu Ala 
    1220                 1225                 1230             


Glu Leu  Ser Val Glu Ala Ala  Ser Tyr Val Thr Asn  Asn Met Thr 
    1235                 1240                 1245             


Lys Pro  Ala Gln Pro Gly 
    1250                 


