                         SEQUENCE LISTING

<110>  ARROWHEAD PHARMACEUTICALS, INC.

<120>  RNAi Agents and Compositions for Inhibiting Expression of 
Apolipoprotein C-III (APOC3)

<130>  30655-WO1

<150>  62/720,434
<151>  2018-08-21

<150>  62/643,927
<151>  2018-03-16

<150>  62/556,818
<151>  2017-09-11

<160>  837

<210>  1
<211>  533
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo Sapiens apolipoprotein C3 (APOC3) transcript, 
GenBank NM_000040.1

<400>  1
tgctcagttc atccctagag gcagctgctc caggaacaga ggtgccatgc agccccgggt   60

actccttgtt gttgccctcc tggcgctcct ggcctctgcc cgagcttcag aggccgagga   120

tgcctccctt ctcagcttca tgcagggtta catgaagcac gccaccaaga ccgccaagga   180

tgcactgagc agcgtgcagg agtcccaggt ggcccagcag gccaggggct gggtgaccga   240

tggcttcagt tccctgaaag actactggag caccgttaag gacaagttct ctgagttctg   300

ggatttggac cctgaggtca gaccaacttc agccgtggct gcctgagacc tcaatacccc   360

aagtccacct gcctatccat cctgcgagct ccttgggtcc tgcaatctcc agggctgccc   420

ctgtaggttg cttaaaaggg acagtattct cagtgctctc ctaccccacc tcatgcctgg   480

cccccctcca ggcatgctgg cctcccaata aagctggaca agaagctgct atg          533


<210>  2
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  2
ucacugagaa uacugucccu c                                                21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence


<400>  3
ucacugagaa uacugucccu c                                                21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  4
ucacugagaa uacugucccg u                                                21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  5
ucacugagaa uacugucccg u                                                21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  6
ucacugagaa uacugucccu c                                                21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  7
uucuugucca gcuuuauugg c                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  8
uucuugucca gcuuuauugg c                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  9
agaauacugu cccuuuuagg g                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  10
agaauacugu cccuuuuagg g                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  11
agaauacugu cccuuuuaag c                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  12
agaauacugu cccuuuuaag c                                                 21


<210>  13
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence

<400>  13
ugagaauacu gucccuuugc c                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  14
ugagaauacu gucccuuugc c                                                 21


<210>  15
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  15
gagggacagu auucucagun a                                                 21


<210>  16
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  20
<223>  n = inosine (hypoxanthine)

<400>  16
gagggacagu auucucagun a                                                 21


<210>  17
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  17
acgggacagu auucucagun a                                                 21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  20
<223>  n = inosine (hypoxanthine)

<400>  18
acgggacagu auucucagun a                                                 21


<210>  19
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  19
gagggacagu auucucagun a                                                 21


<210>  20
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  20
gagggacagu auucucagug a                                                 21


<210>  21
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  21
gagggacagu auucucagug a                                                 21


<210>  22
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  22
gccaauaaag cuggacaaga a                                                 21


<210>  23
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  23
gccaauaaag cuggacaaga a                                                 21


<210>  24
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  24
gccaauaaan cuggacaaga a                                                 21


<210>  25
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  10
<223>  n = inosine (hypoxanthine)

<400>  25
gccaauaaan cuggacaaga a                                                 21


<210>  26
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  26
cccuaaaagg gacaguauuc u                                                 21


<210>  27
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  27
cccuaaaagg gacaguauuc u                                                 21


<210>  28
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  28
gcuuaaaagg gacaguauuc u                                                 21


<210>  29
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  29
gcuuaaaagg gacaguauuc u                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<400>  30
ggcaaaggga caguauucuc a                                                 21


<210>  31
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  31
ggcaaaggga caguauucuc a                                                 21


<210>  32
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  32
gggacaguau ucucagugc                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  33
caauaaagcu ggacaagaa                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  34
uuaaaaggga caguauucu                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  35
cggguacucc uuguuguug                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  36
gguacuccuu guuguugcc                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  37
gcugggugac cgauggcuu                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  38
gaccgauggc uucaguucc                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  39
gcuucaguuc ccugaaaga                                                    19


<210>  40
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  40
ucaguucccu gaaagacua                                                    19


<210>  41
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  41
gacuacugga gcaccguua                                                    19


<210>  42
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  42
acuacuggag caccguuaa                                                    19


<210>  43
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  43
gcaccguuaa ggacaaguu                                                    19


<210>  44
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  44
accguuaagg acaaguucu                                                    19


<210>  45
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  45
ccguuaagga caaguucuc                                                    19


<210>  46
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  46
ccucaauacc ccaagucca                                                    19


<210>  47
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  47
aaaagggaca guauucuca                                                    19


<210>  48
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  APOC3 gene transcript (mRNA) target sequence

<400>  48
agggacagua uucucagug                                                    19


<210>  49
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  49
ucacugagaa uacuguccc                                                    19


<210>  50
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  50
gcacugagaa uacuguccc                                                    19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 

<400>  51
ncacugagaa uacuguccc                                                    19


<210>  52
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  52
ncacugagaa uacuguccn                                                    19


<210>  53
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  53
uucuugucca gcuuuauug                                                    19


<210>  54
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  54
nucuugucca gcuuuauug                                                    19


<210>  55
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  55
nucuugucca gcuuuauun                                                    19


<210>  56
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  56
ugaauacugu cccuuuuaa                                                    19


<210>  57
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  57
agaauacugu cccuuuuaa                                                    19


<210>  58
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  58
agaauacugu cccuuuuag                                                    19


<210>  59
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  59
ngaauacugu cccuuuuaa                                                    19


<210>  60
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  60
ngaauacugu cccuuuuag                                                    19


<210>  61
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  61
ngaauacugu cccuuuuan                                                    19


<210>  62
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  62
uaacaacaag gaguacccg                                                    19


<210>  63
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  63
caacaacaag gaguacccg                                                    19


<210>  64
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  64
naacaacaag gaguacccg                                                    19


<210>  65
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  65
naacaacaag gaguacccn                                                    19


<210>  66
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  66
ugcaacaaca aggaguacc                                                    19


<210>  67
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  67
ggcaacaaca aggaguacc                                                    19


<210>  68
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  68
ngcaacaaca aggaguacc                                                    19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  69
ngcaacaaca aggaguacn                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  70
uagccaucgg ucacccagc                                                    19


<210>  71
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  71
aagccaucgg ucacccagc                                                    19


<210>  72
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  72
nagccaucgg ucacccagc                                                    19


<210>  73
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  73
nagccaucgg ucacccagn                                                    19


<210>  74
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  74
ugaacugaag ccaucgguc                                                    19


<210>  75
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  75
ggaacugaag ccaucgguc                                                    19


<210>  76
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  76
ngaacugaag ccaucgguc                                                    19


<210>  77
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  77
ngaacugaag ccaucggun                                                    19


<210>  78
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  78
ucuuucaggg aacugaagc                                                    19


<210>  79
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  79
ncuuucaggg aacugaagc                                                    19


<210>  80
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  80
ncuuucaggg aacugaagn                                                    19


<210>  81
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  81
uagucuuuca gggaacuga                                                    19


<210>  82
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  82
nagucuuuca gggaacuga                                                    19


<210>  83
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  83
nagucuuuca gggaacugn                                                    19


<210>  84
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  84
uaacggugcu ccaguaguc                                                    19


<210>  85
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase 

<400>  85
naacggugcu ccaguaguc                                                    19


<210>  86
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  86
naacggugcu ccaguagun                                                    19


<210>  87
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  87
uuaacggugc uccaguagu                                                    19


<210>  88
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  88
nuaacggugc uccaguagu                                                    19


<210>  89
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  89
nuaacggugc uccaguagn                                                    19


<210>  90
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  90
uacuuguccu uaacggugc                                                    19


<210>  91
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  91
aacuuguccu uaacggugc                                                    19


<210>  92
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  92
nacuuguccu uaacggugc                                                    19


<210>  93
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  93
nacuuguccu uaacggugn                                                    19


<210>  94
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  94
ugaacuuguc cuuaacggu                                                    19


<210>  95
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  95
agaacuuguc cuuaacggu                                                    19


<210>  96
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  96
ngaacuuguc cuuaacggu                                                    19


<210>  97
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  97
ngaacuuguc cuuaacggn                                                    19


<210>  98
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  98
uagaacuugu ccuuaacgg                                                    19


<210>  99
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  99
gagaacuugu ccuuaacgg                                                    19


<210>  100
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  100
nagaacuugu ccuuaacgg                                                    19


<210>  101
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  101
nagaacuugu ccuuaacgn                                                    19


<210>  102
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  102
uggacuuggg guauugagg                                                    19


<210>  103
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  103
nggacuuggg guauugagg                                                    19


<210>  104
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  104
nggacuuggg guauugagn                                                    19


<210>  105
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  105
ugagaauacu gucccuuuu                                                    19


<210>  106
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  106
ugagaauacu gucccuuug                                                    19


<210>  107
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  107
ngagaauacu gucccuuuu                                                    19


<210>  108
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  108
ngagaauacu gucccuuug                                                    19


<210>  109
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  109
ngagaauacu gucccuuun                                                    19


<210>  110
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  110
uacugagaau acugucccu                                                    19


<210>  111
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<400>  111
cacugagaau acugucccu                                                    19


<210>  112
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = any nucleobase

<400>  112
nacugagaau acugucccu                                                    19


<210>  113
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  113
nacugagaau acugucccn                                                    19


<210>  114
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  114
gggacaguau ucucaguga                                                    19


<210>  115
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  18
<223>  n = inosine (hypoxanthine)

<400>  115
gggacaguau ucucaguna                                                    19


<210>  116
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  116
gggacaguau ucucagugc                                                    19


<210>  117
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  117
gggacaguau ucucagugn                                                    19


<210>  118
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  118
nggacaguau ucucagugn                                                    19


<210>  119
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  119
caauaaagcu ggacaagaa                                                    19


<210>  120
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence


<220>
<221>  modified_base
<222>  8
<223>  n = inosine (hypoxanthine) 

<400>  120
caauaaancu ggacaagaa                                                    19


<210>  121
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  121
caauaaagcu ggacaagan                                                    19


<210>  122
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  122
naauaaagcu ggacaagan                                                    19


<210>  123
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  123
uuaaaaggga caguauuca                                                    19


<210>  124
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  124
uuaaaaggga caguauucu                                                    19


<210>  125
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  125
cuaaaaggga caguauucu                                                    19


<210>  126
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  126
uuaaaaggga caguauucn                                                    19


<210>  127
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  127
cuaaaaggga caguauucn                                                    19


<210>  128
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  128
nuaaaaggga caguauucn                                                    19


<210>  129
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  129
cggguacucc uuguuguua                                                    19


<210>  130
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  130
cggguacucc uuguuguug                                                    19


<210>  131
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  131
cggguacucc uuguuguun                                                    19


<210>  132
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  132
nggguacucc uuguuguun                                                    19


<210>  133
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  133
gguacuccuu guuguugca                                                    19


<210>  134
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  134
gguacuccuu guuguugcc                                                    19


<210>  135
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  135
gguacuccuu guuguugcn                                                    19


<210>  136
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  136
nguacuccuu guuguugcn                                                    19


<210>  137
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  137
gcugggugac cgauggcua                                                    19


<210>  138
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  138
gcugggugac cgauggcuu                                                    19


<210>  139
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  139
gcugggugac cgauggcun                                                    19


<210>  140
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  140
ncugggugac cgauggcun                                                    19


<210>  141
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  141
gaccgauggc uucaguuca                                                    19


<210>  142
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  142
gaccgauggc uucaguucc                                                    19


<210>  143
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  143
gaccgauggc uucaguucn                                                    19


<210>  144
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  144
naccgauggc uucaguucn                                                    19


<210>  145
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  145
gcuucaguuc ccugaaaga                                                    19


<210>  146
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  146
gcuucaguuc ccugaaagn                                                    19


<210>  147
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  147
ncuucaguuc ccugaaagn                                                    19


<210>  148
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  148
ucaguucccu gaaagacua                                                    19


<210>  149
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  149
ucaguucccu gaaagacun                                                    19


<210>  150
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  150
ncaguucccu gaaagacun                                                    19


<210>  151
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  151
gacuacugga gcaccguua                                                    19


<210>  152
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  152
gacuacugga gcaccguun                                                    19


<210>  153
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  153
nacuacugga gcaccguun                                                    19


<210>  154
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  154
acuacuggag caccguuaa                                                    19


<210>  155
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  155
acuacuggag caccguuan                                                    19


<210>  156
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  156
ncuacuggag caccguuan                                                    19


<210>  157
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  157
gcaccguuaa ggacaagua                                                    19


<210>  158
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  158
gcaccguuaa ggacaaguu                                                    19


<210>  159
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  159
gcaccguuaa ggacaagun                                                    19


<210>  160
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  160
ncaccguuaa ggacaagun                                                    19


<210>  161
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  161
accguuaagg acaaguuca                                                    19


<210>  162
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  162
accguuaagg acaaguucu                                                    19


<210>  163
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  163
accguuaagg acaaguucn                                                    19


<210>  164
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  164
nccguuaagg acaaguucn                                                    19


<210>  165
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  165
ccguuaagga caaguucua                                                    19


<210>  166
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  166
ccguuaagga caaguucuc                                                    19


<210>  167
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase 

<400>  167
ccguuaagga caaguucun                                                    19


<210>  168
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  168
ncguuaagga caaguucun                                                    19


<210>  169
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  169
ccucaauacc ccaagucca                                                    19


<210>  170
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  170
ccucaauacc ccaaguccn                                                    19


<210>  171
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  171
ncucaauacc ccaaguccn                                                    19


<210>  172
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  172
aaaagggaca guauucuca                                                    19


<210>  173
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  173
caaagggaca guauucuca                                                    19


<210>  174
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  174
aaaagggaca guauucucn                                                    19


<210>  175
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  175
caaagggaca guauucucn                                                    19


<210>  176
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase 

<400>  176
naaagggaca guauucucn                                                    19


<210>  177
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  177
agggacagua uucucagua                                                    19


<210>  178
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<400>  178
agggacagua uucucagug                                                    19


<210>  179
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = any nucleobase

<400>  179
agggacagua uucucagun                                                    19


<210>  180
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand core 19-mer base sequence

<220>
<221>  modified_base
<222>  1, 19
<223>  n = any nucleobase

<400>  180
ngggacagua uucucagun                                                    19


<210>  181
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  181
uaacaacaag gaguacccgu u                                                 21


<210>  182
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  182
uaacaacaag gaguacccgu u                                                 21


<210>  183
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  183
uaacaacaag gaguacccgg u                                                 21


<210>  184
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  184
uaacaacaag gaguacccgg g                                                 21


<210>  185
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  185
uaacaacaag gaguacccgg g                                                 21


<210>  186
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  186
ugcaacaaca aggaguaccu u                                                 21


<210>  187
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  187
ugcaacaaca aggaguaccu u                                                 21


<210>  188
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  188
ugcaacaaca aggaguaccc u                                                 21


<210>  189
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  189
ugcaacaaca aggaguaccc g                                                 21


<210>  190
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  190
ugcaacaaca aggaguaccc g                                                 21


<210>  191
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  191
uagccaucgg ucacccagcu u                                                 21


<210>  192
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  192
uagccaucgg ucacccagcu u                                                 21


<210>  193
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  193
uagccaucgg ucacccagcc u                                                 21


<210>  194
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  194
uagccaucgg ucacccagcc c                                                 21


<210>  195
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  195
uagccaucgg ucacccagcc c                                                 21


<210>  196
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  196
ugaacugaag ccaucggucu u                                                 21


<210>  197
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  197
ugaacugaag ccaucggucu u                                                 21


<210>  198
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  198
ugaacugaag ccaucgguca u                                                 21


<210>  199
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  199
ugaacugaag ccaucgguca c                                                 21


<210>  200
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  200
ugaacugaag ccaucgguca c                                                 21


<210>  201
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  201
ucuuucaggg aacugaagcu u                                                 21


<210>  202
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  202
ucuuucaggg aacugaagcu u                                                 21


<210>  203
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  203
ucuuucaggg aacugaagcc u                                                 21


<210>  204
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  204
ucuuucaggg aacugaagcc a                                                 21


<210>  205
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  205
ucuuucaggg aacugaagcc a                                                 21


<210>  206
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  206
uaacggugcu ccaguagucu u                                                 21


<210>  207
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  207
uaacggugcu ccaguagucu u                                                 21


<210>  208
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  208
uaacggugcu ccaguagucu u                                                 21


<210>  209
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  209
uaacggugcu ccaguagucu u                                                 21


<210>  210
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  210
uaacggugcu ccaguagucu u                                                 21


<210>  211
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  211
uuaacggugc uccaguaguu u                                                 21


<210>  212
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  212
uuaacggugc uccaguaguu u                                                 21


<210>  213
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  213
uuaacggugc uccaguaguc u                                                 21


<210>  214
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  214
uuaacggugc uccaguaguc u                                                 21


<210>  215
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  215
uuaacggugc uccaguaguc u                                                 21


<210>  216
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  216
uacuuguccu uaacggugcu u                                                 21


<210>  217
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  217
uacuuguccu uaacggugcu u                                                 21


<210>  218
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  218
uacuuguccu uaacggugcu u                                                 21


<210>  219
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  219
uacuuguccu uaacggugcu c                                                 21


<210>  220
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  220
uacuuguccu uaacggugcu c                                                 21


<210>  221
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  221
ugaacuuguc cuuaacgguu u                                                 21


<210>  222
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  222
ugaacuuguc cuuaacgguu u                                                 21


<210>  223
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  223
ugaacuuguc cuuaacggug u                                                 21


<210>  224
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  224
ugaacuuguc cuuaacggug c                                                 21


<210>  225
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  225
ugaacuuguc cuuaacggug c                                                 21


<210>  226
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  226
uagaacuugu ccuuaacggu u                                                 21


<210>  227
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  227
uagaacuugu ccuuaacggu u                                                 21


<210>  228
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  228
uagaacuugu ccuuaacggu u                                                 21


<210>  229
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  229
uagaacuugu ccuuaacggu g                                                 21


<210>  230
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  230
uagaacuugu ccuuaacggu g                                                 21


<210>  231
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  231
uggacuuggg guauugaggu u                                                 21


<210>  232
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  232
uggacuuggg guauugaggu u                                                 21


<210>  233
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  233
uggacuuggg guauugaggu u                                                 21


<210>  234
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  234
uggacuuggg guauugaggu c                                                 21


<210>  235
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  235
uggacuuggg guauugaggu c                                                 21


<210>  236
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  236
ugagaauacu gucccuuuuu u                                                 21


<210>  237
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  237
ugagaauacu gucccuuuuu u                                                 21


<210>  238
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  238
ugagaauacu gucccuuuua u                                                 21


<210>  239
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  239
ugagaauacu gucccuuuua a                                                 21


<210>  240
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  240
ugagaauacu gucccuuuua a                                                 21


<210>  241
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  241
uacugagaau acugucccuu u                                                 21


<210>  242
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  242
uacugagaau acugucccuu u                                                 21


<210>  243
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  243
uacugagaau acugucccuu u                                                 21


<210>  244
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  244
uacugagaau acugucccuu u                                                 21


<210>  245
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  245
uacugagaau acugucccuu u                                                 21


<210>  246
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  246
cggguacucc uuguuguuau u                                                 21


<210>  247
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  247
cggguacucc uuguuguuau u                                                 21


<210>  248
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  248
ccggguacuc cuuguuguua                                                   20


<210>  249
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  249
cccggguacu ccuuguuguu a                                                 21


<210>  250
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  250
cccggguacu ccuuguuguu a                                                 21


<210>  251
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  251
gguacuccuu guuguugcau u                                                 21


<210>  252
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  252
gguacuccuu guuguugcau u                                                 21


<210>  253
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  253
ggguacuccu uguuguugca                                                   20


<210>  254
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  254
cggguacucc uuguuguugc a                                                 21


<210>  255
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  255
cggguacucc uuguuguugc a                                                 21


<210>  256
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  256
gcugggugac cgauggcuau u                                                 21


<210>  257
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  257
gcugggugac cgauggcuau u                                                 21


<210>  258
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  258
ggcuggguga ccgauggcua                                                   20


<210>  259
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  259
gggcugggug accgauggcu a                                                 21


<210>  260
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  260
gggcugggug accgauggcu a                                                 21


<210>  261
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  261
gaccgauggc uucaguucau u                                                 21


<210>  262
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  262
gaccgauggc uucaguucau u                                                 21


<210>  263
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  263
ugaccgaugg cuucaguuca                                                   20


<210>  264
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  264
gugaccgaug gcuucaguuc a                                                 21


<210>  265
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  265
gugaccgaug gcuucaguuc a                                                 21


<210>  266
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  266
gcuucaguuc ccugaaagau u                                                 21


<210>  267
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  267
gcuucaguuc ccugaaagau u                                                 21


<210>  268
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  268
ggcuucaguu cccugaaaga                                                   20


<210>  269
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  269
uggcuucagu ucccugaaag a                                                 21


<210>  270
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  270
uggcuucagu ucccugaaag a                                                 21


<210>  271
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  271
gacuacugga gcaccguuau u                                                 21


<210>  272
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  272
gacuacugga gcaccguuau u                                                 21


<210>  273
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  273
agacuacugg agcaccguua                                                   20


<210>  274
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  274
aagacuacug gagcaccguu a                                                 21


<210>  275
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  275
aagacuacug gagcaccguu a                                                 21


<210>  276
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  276
acuacuggag caccguuaau u                                                 21


<210>  277
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  277
acuacuggag caccguuaau u                                                 21


<210>  278
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  278
gacuacugga gcaccguuaa                                                   20


<210>  279
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  279
agacuacugg agcaccguua a                                                 21


<210>  280
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  280
agacuacugg agcaccguua a                                                 21


<210>  281
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  281
gcaccguuaa ggacaaguau u                                                 21


<210>  282
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  282
gcaccguuaa ggacaaguau u                                                 21


<210>  283
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  283
agcaccguua aggacaagua                                                   20


<210>  284
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  284
gagcaccguu aaggacaagu a                                                 21


<210>  285
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  285
gagcaccguu aaggacaagu a                                                 21


<210>  286
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  286
accguuaagg acaaguucau u                                                 21


<210>  287
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  287
accguuaagg acaaguucau u                                                 21


<210>  288
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  288
caccguuaag gacaaguuca                                                   20


<210>  289
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  289
gcaccguuaa ggacaaguuc a                                                 21


<210>  290
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  290
gcaccguuaa ggacaaguuc a                                                 21


<210>  291
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  291
ccguuaagga caaguucuau u                                                 21


<210>  292
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  292
ccguuaagga caaguucuau u                                                 21


<210>  293
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  293
accguuaagg acaaguucua                                                   20


<210>  294
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  294
caccguuaag gacaaguucu a                                                 21


<210>  295
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  295
caccguuaag gacaaguucu a                                                 21


<210>  296
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  296
ccucaauacc ccaaguccau u                                                 21


<210>  297
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  297
ccucaauacc ccaaguccau u                                                 21


<210>  298
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  298
accucaauac cccaagucca                                                   20


<210>  299
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  299
gaccucaaua ccccaagucc a                                                 21


<210>  300
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  300
gaccucaaua ccccaagucc a                                                 21


<210>  301
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  301
aaaagggaca guauucucau u                                                 21


<210>  302
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  302
aaaagggaca guauucucau u                                                 21


<210>  303
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  303
uaaaagggac aguauucuca                                                   20


<210>  304
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  304
uuaaaaggga caguauucuc a                                                 21


<210>  305
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  305
uuaaaaggga caguauucuc a                                                 21


<210>  306
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  306
agggacagua uucucaguau u                                                 21


<210>  307
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  307
agggacagua uucucaguau u                                                 21


<210>  308
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  308
aagggacagu auucucagua                                                   20


<210>  309
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  309
aaagggacag uauucucagu a                                                 21


<210>  310
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  310
aaagggacag uauucucagu a                                                 21


<210>  311
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  311
uacuuguccu uaacggugcu u                                                 21


<210>  312
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  312
uacuuguccu uaacggugcu c                                                 21


<210>  313
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  313
aacuuguccu uaacggugcu u                                                 21


<210>  314
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  314
uggacuuggg guauugaggu u                                                 21


<210>  315
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  315
uggacuuggg guauugaggu c                                                 21


<210>  316
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  316
ucuuucaggg aacugaagcu u                                                 21


<210>  317
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  317
ucuuucaggg aacugaagcc u                                                 21


<210>  318
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  318
ugaacugaag ccaucggucu u                                                 21


<210>  319
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  319
ugaacugaag ccaucgguca c                                                 21


<210>  320
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  320
ugagaauacu gucccuuuug g                                                 21


<210>  321
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  321
ugagaauacu gucccuuuug cg                                                22


<210>  322
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  322
uaacggugcu ccaguagucu u                                                 21


<210>  323
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  323
uaacggugcu ccaguagucg u                                                 21


<210>  324
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  324
uacugagaau acugucccuu u                                                 21


<210>  325
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  325
uacugagaau acugucccug u                                                 21


<210>  326
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  326
uuaacggugc uccaguaguc u                                                 21


<210>  327
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  327
uuaacggugc uccaguaggc u                                                 21


<210>  328
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  328
uagccaucgg ucacccagcu u                                                 21


<210>  329
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  329
aagccaucgg ucacccagcu u                                                 21


<210>  330
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  330
uagaacuugu ccuuaacggu u                                                 21


<210>  331
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  331
uagaacuugu ccuuaacggu g                                                 21


<210>  332
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  332
ugaacuuguc cuuaacgguu u                                                 21


<210>  333
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  333
agaacuuguc cuuaacgguu u                                                 21


<210>  334
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  334
ugaacuuguc cuuaacggug c                                                 21


<210>  335
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  335
ugcaacaaca aggaguaccu u                                                 21


<210>  336
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  336
ugcaacaaca aggaguaccc g                                                 21


<210>  337
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  337
uaacaacaag gaguacccgu u                                                 21


<210>  338
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  338
ugcacugaga auacuguccc uu                                                22


<210>  339
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  339
agcacugaga auacuguccc uu                                                22


<210>  340
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  340
cuacuugucc uuaacggugc uu                                                22


<210>  341
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  341
aacuuguccu uaacggugcu c                                                 21


<210>  342
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  342
uacuuguccu uaacggugc                                                    19


<210>  343
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  343
uacuuguccu uaacggugcu cc                                                22


<210>  344
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  344
uacuuguccu uaacggugcu cuu                                               23


<210>  345
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  345
uacuuguccu uaacggugcu cca                                               23


<210>  346
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  346
aacuuguccu uaacggugc                                                    19


<210>  347
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  347
aacuuguccu uaacggugcu cc                                                22


<210>  348
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  348
ugagaauacu gucccuuuuu u                                                 21


<210>  349
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  349
ugagaauacu gucccuuuug u                                                 21


<210>  350
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  350
ugagaauacu gucccuuuug g                                                 21


<210>  351
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  351
agagaauacu gucccuuuug g                                                 21


<210>  352
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  352
ugcaacaaca aggaguacc                                                    19


<210>  353
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  353
ugcaacaaca aggaguaccc u                                                 21


<210>  354
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  354
ugcaacaaca aggaguaccu u                                                 21


<210>  355
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  355
ugcaacaaca aggaguaccu u                                                 21


<210>  356
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  356
ugcaacaaca aggaguaccu u                                                 21


<210>  357
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  357
agcaacaaca aggaguaccu u                                                 21


<210>  358
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  358
ucugaagcca ucggucaccc a                                                 21


<210>  359
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  359
acugaagcca ucggucaccc a                                                 21


<210>  360
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  360
uggaacugaa gccaucgguc a                                                 21


<210>  361
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  361
uggaacugaa gccaucgguc c                                                 21


<210>  362
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  362
uucuuucagg gaacugaagc c                                                 21


<210>  363
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  363
uuuaacggug cuccaguagu c                                                 21


<210>  364
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  364
uccuuaacgg ugcuccagua g                                                 21


<210>  365
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  365
uuccuuaacg gugcuccagu a                                                 21


<210>  366
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  366
uuccuuaacg gugcuccagu c                                                 21


<210>  367
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  367
uacuuguccu uaacggugcu c                                                 21


<210>  368
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  368
aacuuguccu uaacggugcu c                                                 21


<210>  369
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  369
uugaggucuc aggcagccac u                                                 21


<210>  370
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  370
uuauugaggu cucaggcagc c                                                 21


<210>  371
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  371
uguauugagg ucucaggcag c                                                 21


<210>  372
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  372
ucacugagaa uacugucccu u                                                 21


<210>  373
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  373
ucacugagaa uacugucccu u                                                 21


<210>  374
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  374
ucuuuuaagc aaccuacagg g                                                 21


<210>  375
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  375
ugagaauacu gucccuuuuc c                                                 21


<210>  376
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  376
uuauugaggu cucaggcagc c                                                 21


<210>  377
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  377
ugagaauacu gucccuuuuc c                                                 21


<210>  378
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  378
ugagaauacu gucccuuuuc u                                                 21


<210>  379
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  379
uucuugucca gcuuuauugg g                                                 21


<210>  380
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  380
uagucuuuca gggaacugaa g                                                 21


<210>  381
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  381
uagucuuuca gggaacugaa c                                                 21


<210>  382
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  382
ucacugagaa uacugucccu u                                                 21


<210>  383
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  383
ucacugagaa uacuguccgu u                                                 21


<210>  384
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  384
uagucuuuca gggaacugac g                                                 21


<210>  385
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  385
uagucuuuca gggaacugag g                                                 21


<210>  386
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  386
uagucuuuca gggaacugac c                                                 21


<210>  387
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  387
uagucuuuca gggaacugag c                                                 21


<210>  388
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  388
agaauacugu cccuuuuagg c                                                 21


<210>  389
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  389
agaauacugu cccuuuuaag g                                                 21


<210>  390
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  390
ugcaacaaca aggaguaccc u                                                 21


<210>  391
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  391
uagucuuuca gggaacugaa g                                                 21


<210>  392
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  392
agaauacugu cccuuuuaag c                                                 21


<210>  393
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  393
ugagaauacu gucccuuugc c                                                 21


<210>  394
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  394
ucacugagaa uacugucccu c                                                 21


<210>  395
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  395
uucuugucca gcuuuauugg c                                                 21


<210>  396
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  396
agaauacugu cccuuuuagg u                                                 21


<210>  397
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  397
agaauacugu cccuuuuacg c                                                 21


<210>  398
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  398
agaauacugu cccuuuuaga c                                                 21


<210>  399
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  399
agaauacugu cccuuuuagg c                                                 21


<210>  400
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  400
uucuugucca gcuuuauugg c                                                 21


<210>  401
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  401
ucacugagaa uacugucccu g                                                 21


<210>  402
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  402
ucacugagaa uacugucccc u                                                 21


<210>  403
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  403
ucacugagaa uacugucccu c                                                 21


<210>  404
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  404
ucacugagaa uacugucccu c                                                 21


<210>  405
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  405
ucacugagaa uacugucccu c                                                 21


<210>  406
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  406
ucacugagaa uacugucccu c                                                 21


<210>  407
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  407
agugcauccu uggcggucuu u                                                 21


<210>  408
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  408
agugcauccu uggcggucuu u                                                 21


<210>  409
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  409
aguagucuuu cagggaacug a                                                 21


<210>  410
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  410
aguagucuuu cagggaacug a                                                 21


<210>  411
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  411
uguagucuuu cagggaacug a                                                 21


<210>  412
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  412
ucuuaacggu gcuccaguag u                                                 21


<210>  413
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  413
uccuuuuaag caaccuacag g                                                 21


<210>  414
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  414
uccuuuuaag caaccuacag c                                                 21


<210>  415
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand modified sequence 

<400>  415
uagucuuuca gggaacugac c                                                 21


<210>  416
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  416
gcaccguuaa ggacaaguau u                                                 21


<210>  417
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  417
gagcaccguu aaggacaagu a                                                 21


<210>  418
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  418
gcaccguuaa ggacaagua                                                    19


<210>  419
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  419
gcaccguuaa ggacaaguu                                                    19


<210>  420
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  420
ccucaauacc ccaagucca                                                    19


<210>  421
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  421
gaccucaaua ccccaagucc a                                                 21


<210>  422
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  422
gcuucaguuc ccugaaaga                                                    19


<210>  423
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  423
ggcuucaguu cccugaaaga                                                   20


<210>  424
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  424
gaccgauggc uucaguuca                                                    19


<210>  425
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  425
gugaccgaug gcuucaguuc a                                                 21


<210>  426
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  426
ccaaaaggga caguauucuc a                                                 21


<210>  427
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  427
cgcaaaaggg acaguauucu ca                                                22


<210>  428
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  428
gacuacugga gcaccguua                                                    19


<210>  429
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  429
gacuacugga gcacuguua                                                    19


<210>  430
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  430
cgacuacugg agcaccguua                                                   20


<210>  431
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  431
gacuacugga gcaucguua                                                    19


<210>  432
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  432
agggacagua uucucagua                                                    19


<210>  433
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  433
cagggacagu auucucagua                                                   20


<210>  434
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  434
gacuacugga gcaccguuaa                                                   20


<210>  435
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  435
gccuacugga gcaccguuaa                                                   20


<210>  436
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  436
gccuacugga gcacuguuaa                                                   20


<210>  437
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  437
gcugggugac cgauggcua                                                    19


<210>  438
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  438
gcugggugac cgauggcuu                                                    19


<210>  439
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  439
gcugggugac cgaugacua                                                    19


<210>  440
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  440
ccguuaagga caaguucua                                                    19


<210>  441
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  441
caccguuaag gacaaguucu a                                                 21


<210>  442
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  442
accguuaagg acaaguuca                                                    19


<210>  443
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  443
accguuaagg acaaguucu                                                    19


<210>  444
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  444
gcaccguuaa ggacaaguuc a                                                 21


<210>  445
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  445
gguacuccuu guuguugca                                                    19


<210>  446
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  446
cggguacucc uuguuguugc a                                                 21


<210>  447
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  447
cggguacucc uuguuguua                                                    19


<210>  448
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  448
gggacaguau ucucagugca                                                   20


<210>  449
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  449
gggacaguau ucucagugcu                                                   20


<210>  450
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  450
gcaccguuaa ggacaaguuu u                                                 21


<210>  451
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  451
gagcaccguu aaggacaagu a                                                 21


<210>  452
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  452
ggagcaccgu uaaggacaag ua                                                22


<210>  453
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  453
gagcaccguu aaggacaagu u                                                 21


<210>  454
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  454
ggagcaccgu uaaggacaag uu                                                22


<210>  455
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  455
aaaagggaca guauucucau u                                                 21


<210>  456
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  456
caaaagggac aguauucuca                                                   20


<210>  457
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  457
ccaaaaggga caguauucuc a                                                 21


<210>  458
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  458
ccaaaaggga caguauucuc u                                                 21


<210>  459
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  459
gguacuccuu guuguugcau u                                                 21


<210>  460
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  460
ggguacuccu uguuguugca                                                   20


<210>  461
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  461
gguacuccuu guuguugca                                                    19


<210>  462
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  462
gguacuccuu guuguugcu                                                    19


<210>  463
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  463
ugggugaccg auggcuucag a                                                 21


<210>  464
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  464
ugggugaccg auggcuucag u                                                 21


<210>  465
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  465
ugaccgaugg cuucaguucc a                                                 21


<210>  466
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  466
ggaccgaugg cuucaguucc a                                                 21


<210>  467
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  467
ggcuucaguu cccugaaaga a                                                 21


<210>  468
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  468
gacuacugga gcaccguuaa a                                                 21


<210>  469
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  469
cuacuggagc accguuaagg a                                                 21


<210>  470
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  470
uacuggagca ccguuaagga a                                                 21


<210>  471
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  471
gacuggagca ccguuaagga a                                                 21


<210>  472
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  472
gagcaccguu aaggacaagu a                                                 21


<210>  473
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  473
gagcaccguu aaggacaagu u                                                 21


<210>  474
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  474
aguggcugcc ugagaccuca a                                                 21


<210>  475
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  475
ggcugccuga gaccucaaua a                                                 21


<210>  476
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  476
gcugccugag accucaauac a                                                 21


<210>  477
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  477
aagggacagu auucucagug a                                                 21


<210>  478
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  478
acgggacagu auucucagug a                                                 21


<210>  479
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  479
cccuguaggu ugcuuaaaag a                                                 21


<210>  480
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  480
ggaaaaggga caguauucuc a                                                 21


<210>  481
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  481
ggaaaaggga caguauucuc a                                                 21


<210>  482
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  482
gagggacagu auucucagug a                                                 21


<210>  483
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  483
ggcaaaggga caguauucuc a                                                 21


<210>  484
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  484
ggcaaaggga caguauucuc a                                                 21


<210>  485
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  485
ugaccgaugg cuucanuucc a                                                 21


<210>  486
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  486
ugaccgaugg cuucaguucc a                                                 21


<210>  487
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  16
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  487
ugaccgaugg cuucanuucc a                                                 21


<210>  488
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  488
gagggacagu auucucagug a                                                 21


<210>  489
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  489
ggcugccuga gaccucaaua a                                                 21


<210>  490
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  3
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  490
ggnaaaggga caguauucuc a                                                 21


<210>  491
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  491
ngaaaaggga caguauucuc a                                                 21


<210>  492
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  1, 2
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  492
nnaaaaggga caguauucuc a                                                 21


<210>  493
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  493
cccaauaaag cuggacaaga a                                                 21


<210>  494
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  494
gccaauaaag cuggacaaga a                                                 21


<210>  495
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  495
cuucaguucc cugaaagacu a                                                 21


<210>  496
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  496
guucaguucc cugaaagacu a                                                 21


<210>  497
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  497
gcuuaaaagg gacaguauuc u                                                 21


<210>  498
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  498
gggacaguau ucucagugau u                                                 21


<210>  499
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  1
<223>  n = 2'-O-methyl-2-aminoadenosine-3'-phosphate

<400>  499
nagggacagu auucucagug a                                                 21


<210>  500
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  18
<223>  n = 2'-O-methylinosine-3'-phosphate  

<400>  500
gagggacagu auucucanug a                                                 21


<210>  501
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  501
gagggacagu auucucagun a                                                 21


<210>  502
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  502
acgggacagu auucucagug a                                                 21


<210>  503
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  503
gggacaguau ucucagugau u                                                 21


<210>  504
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  504
cggacaguau ucucagugau u                                                 21


<210>  505
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  505
ggcaaaggga caguauucuc a                                                 21


<210>  506
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  8
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  506
ggcaaagnga caguauucuc a                                                 21


<210>  507
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  7
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  507
ggcaaangga caguauucuc a                                                 21


<210>  508
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  508
aggguacucc uuguuguugc a                                                 21


<210>  509
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  509
cuucaguucu cugaaagacu a                                                 21


<210>  510
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  510
cuucaguuuc cugaaagacu a                                                 21


<210>  511
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  511
cgucaguucc cugaaagacu a                                                 21


<210>  512
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  512
ccucaguucc cugaaagacu a                                                 21


<210>  513
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  513
cgucaguucu cugaaagacu a                                                 21


<210>  514
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  514
ggucaguucc cugaaagacu a                                                 21


<210>  515
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  515
gcucaguucc cugaaagacu a                                                 21


<210>  516
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  516
gccuaaaagg gacaguauuc u                                                 21


<210>  517
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  517
ccuuaaaagg gacaguauuc u                                                 21


<210>  518
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  518
gcuuaaaagg nacaguauuc u                                               21


<210>  519
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  519
gcuuaaaagn gacaguauuc u                                               21


<210>  520
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence

<220>
<221>  modified_base
<222>  9
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  520
gcuuaaaang gacaguauuc u                                               21


<210>  521
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  521
cccuaaaagg gacaguauuc u                                               21


<210>  522
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  19
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  522
aggguacucc uuguuguunc a                                                 21


<210>  523
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  523
aggguacucc uuguuguugc a                                                 21


<210>  524
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  19
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  524
cuucaguucc cugaaaganu a                                                21


<210>  525
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  525
cuucaguucc cugaaagacu a                                                 21


<210>  526
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  526
gcuuaaaagg gacaguauun u                                                 21


<210>  527
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  527
gcuuaaaagg gacaguauuc u                                                 21


<210>  528
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  528
ggcaaaggga caguauucun a                                                 21


<210>  529
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  529
ggcaaaggga caguauucuc a                                                 21


<210>  530
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  530
gagggacagu auucucagun a                                                 21


<210>  531
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  19
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  531
gccaauaaag cuggacaana a                                                 21


<210>  532
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  532
gccaauaaag cuggacaaga a                                                 21


<210>  533
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  533
aggguacucu nuguuguugc a                                                 21


<210>  534
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  9
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  534
aggguacunc uuguuguugc a                                                21


<210>  535
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  535
cuucaguucc nugaaagacu a                                                21


<210>  536
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  536
cuucaguucn cugaaagacu a                                                21


<210>  537
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  9
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  537
cuucaguunc cugaaagacu a                                                21


<210>  538
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  538
gcuuaaaagg nacaguauuc u                                                21


<210>  539
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  539
gcuuaaaagn gacaguauuc u                                                 21


<210>  540
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  9
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  540
gcuuaaaang gacaguauuc u                                                 21


<210>  541
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  541
ggcaaaggga naguauucuc a                                                21


<210>  542
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  9
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  542
ggcaaaggna caguauucuc a                                              21


<210>  543
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  9
<223>  n = 2'-fluoroinosine-3'-phosphate 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  543
gagggacanu auucucagun a                                               21


<210>  544
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  544
gccaauaaag nuggacaaga a                                                 21


<210>  545
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  545
gccaauaaan cuggacaaga a                                                 21


<210>  546
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  546
gccuaaaagg nacaguauuc u                                                 21


<210>  547
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  547
gccuaaaagg nacaguauuc u                                                21


<210>  548
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  548
accuaaaagg gacaguauuc u                                                 21


<210>  549
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  549
gcguaaaagg gacaguauuc u                                                 21


<210>  550
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  550
gucuaaaagg gacaguauuc u                                                 21


<210>  551
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  551
gagggacagu auucucagug a                                                 21


<210>  552
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  18
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  552
gggacaguau ucucagunau u                                                 21


<210>  553
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  553
gccaauaaag cuggacaaga a                                                 21


<210>  554
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  554
gccuaaaagg gacaguauuc u                                                 21


<210>  555
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  555
gccuaaaagg nacaguauuc u                                                 21


<210>  556
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  556
gagggacagu auucucagug a                                                 21


<210>  557
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  557
gagggacagu auucucaguna                                                  21


<210>  558
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  558
gccaauaaag cuggacaaga a                                                 21


<210>  559
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  559
gccaauaaag cuggacaaga a                                                 21


<210>  560
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  560
gccaauaaag cuggacaaga a                                                 21


<210>  561
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  561
gccaauaaag cuggacaaga a                                                 21


<210>  562
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  562
gccaauaaag cuggacaaga a                                                 21


<210>  563
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  563
gccaauaaan cuggacaaga a                                                 21


<210>  564
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  564
gccaauaaan cuggacaaga a                                                 21


<210>  565
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  10
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  565
gccaauaaan cuggacaaga a                                                 21


<210>  566
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  13
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  566
gccaauaaag cungacaaga a                                                 21


<210>  567
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  14
<223>  n = 2'-O-methylinosine-3'-phosphate

<400>  567
gccaauaaag cugnacaaga a                                                 21


<210>  568
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  568
gccuaaaagg gacaguauuc u                                                 21


<210>  569
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  569
gccuaaaagg gacaguauuc u                                                 21


<210>  570
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  570
gccuaaaagg nacaguauuc u                                                 21


<210>  571
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  11
<223>  n = 2'-fluoroinosine-3'-phosphate 

<400>  571
gccuaaaagg nacaguauuc u                                                 21


<210>  572
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  572
acgggacagu auucucagun a                                                 21


<210>  573
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  573
cagggacagu auucucagug a                                                 21


<210>  574
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  574
cagggacagu auucucagun a                                                 21


<210>  575
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  575
aggggacagu auucucagug a                                                 21


<210>  576
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  20
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  576
aggggacagu auucucagun a                                                 21


<210>  577
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  577
agaccgccaa ggaugcacuu u                                                 21


<210>  578
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  15
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  578
agaccgccaa ggauncacuu u                                                 21


<210>  579
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  579
ucaguucccu gaaagacuac u                                                 21


<210>  580
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  580
ucaguucccu gaaagacuac a                                                 21


<210>  581
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<220>
<221>  modified_base
<222>  15
<223>  n = 2'-O-methylinosine-3'-phosphate 

<400>  581
acuacuggag caccnuuaag a                                                 21


<210>  582
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  582
ccuguagguu gcuuaaaagg a                                                 21


<210>  583
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  583
gcuguagguu gcuuaaaagg a                                                 21


<210>  584
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand modified sequence 

<400>  584
ggucaguucu cugaaagacu a                                                 21


<210>  585
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  585
uaacaacaag gaguacccgu u                                                 21


<210>  586
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  586
uaacaacaag gaguacccgg u                                                 21


<210>  587
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  587
uaacaacaag gaguacccgg g                                                 21


<210>  588
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  588
ugcaacaaca aggaguaccu u                                                 21


<210>  589
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  589
ugcaacaaca aggaguaccc u                                                 21


<210>  590
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  590
ugcaacaaca aggaguaccc g                                                 21


<210>  591
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  591
uagccaucgg ucacccagcu u                                                 21


<210>  592
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  592
uagccaucgg ucacccagcc u                                                 21


<210>  593
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  593
uagccaucgg ucacccagcc c                                                 21


<210>  594
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  594
ugaacugaag ccaucggucu u                                                 21


<210>  595
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  595
ugaacugaag ccaucgguca u                                                 21


<210>  596
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  596
ugaacugaag ccaucgguca c                                                 21


<210>  597
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  597
ucuuucaggg aacugaagcu u                                                 21


<210>  598
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  598
ucuuucaggg aacugaagcc u                                                 21


<210>  599
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  599
ucuuucaggg aacugaagcc a                                                 21


<210>  600
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  600
uaacggugcu ccaguagucu u                                                 21


<210>  601
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  601
uuaacggugc uccaguaguu u                                                 21


<210>  602
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  602
uuaacggugc uccaguaguc u                                                 21


<210>  603
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  603
uacuuguccu uaacggugcu u                                                 21


<210>  604
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  604
uacuuguccu uaacggugcu c                                                 21


<210>  605
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  605
ugaacuuguc cuuaacgguu u                                                 21


<210>  606
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  606
ugaacuuguc cuuaacggug u                                                 21


<210>  607
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  607
ugaacuuguc cuuaacggug c                                                 21


<210>  608
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  608
uagaacuugu ccuuaacggu u                                                 21


<210>  609
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  609
uagaacuugu ccuuaacggu g                                                 21


<210>  610
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  610
uggacuuggg guauugaggu u                                                 21


<210>  611
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  611
uggacuuggg guauugaggu c                                                 21


<210>  612
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  612
ugagaauacu gucccuuuuu u                                                 21


<210>  613
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  613
ugagaauacu gucccuuuua u                                                 21


<210>  614
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  614
ugagaauacu gucccuuuua a                                                 21


<210>  615
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  615
uacugagaau acugucccuu u                                                 21


<210>  616
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  616
cggguacucc uuguuguuau u                                                 21


<210>  617
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  617
ccggguacuc cuuguuguua                                                   20


<210>  618
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  618
cccggguacu ccuuguuguu a                                                 21


<210>  619
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  619
gguacuccuu guuguugcau u                                                 21


<210>  620
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  620
ggguacuccu uguuguugca                                                   20


<210>  621
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  621
cggguacucc uuguuguugc a                                                 21


<210>  622
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  622
gcugggugac cgauggcuau u                                                 21


<210>  623
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  623
ggcuggguga ccgauggcua                                                   20


<210>  624
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  624
gggcugggug accgauggcu a                                                 21


<210>  625
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  625
gaccgauggc uucaguucau u                                                 21


<210>  626
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  626
ugaccgaugg cuucaguuca                                                   20


<210>  627
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  627
gugaccgaug gcuucaguuc a                                                 21


<210>  628
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  628
gcuucaguuc ccugaaagau u                                                 21


<210>  629
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  629
ggcuucaguu cccugaaaga                                                   20


<210>  630
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  630
uggcuucagu ucccugaaag a                                                 21


<210>  631
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  631
gacuacugga gcaccguuau u                                                 21


<210>  632
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  632
agacuacugg agcaccguua                                                   20


<210>  633
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  633
aagacuacug gagcaccguu a                                                 21


<210>  634
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  634
acuacuggag caccguuaau u                                                 21


<210>  635
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  635
gacuacugga gcaccguuaa                                                   20


<210>  636
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  636
agacuacugg agcaccguua a                                                 21


<210>  637
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  637
gcaccguuaa ggacaaguau u                                                 21


<210>  638
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  638
agcaccguua aggacaagua                                                   20


<210>  639
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  639
gagcaccguu aaggacaagu a                                                 21


<210>  640
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  640
accguuaagg acaaguucau u                                                 21


<210>  641
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  641
caccguuaag gacaaguuca                                                   20


<210>  642
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  642
gcaccguuaa ggacaaguuc a                                                 21


<210>  643
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  643
ccguuaagga caaguucuau u                                                 21


<210>  644
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  644
accguuaagg acaaguucua                                                   20


<210>  645
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  645
caccguuaag gacaaguucu a                                                 21


<210>  646
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  646
ccucaauacc ccaaguccau u                                                 21


<210>  647
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  647
accucaauac cccaagucca                                                   20


<210>  648
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  648
gaccucaaua ccccaagucc a                                                 21


<210>  649
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  649
aaaagggaca guauucucau u                                                 21


<210>  650
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  650
uaaaagggac aguauucuca                                                   20


<210>  651
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  651
uuaaaaggga caguauucuc a                                                 21


<210>  652
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  652
agggacagua uucucaguau u                                                 21


<210>  653
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  653
aagggacagu auucucagua                                                   20


<210>  654
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  654
aaagggacag uauucucagu a                                                 21


<210>  655
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  655
aacuuguccu uaacggugcu u                                                 21


<210>  656
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  656
ugagaauacu gucccuuuug g                                                 21


<210>  657
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  657
ugagaauacu gucccuuuug cg                                                22


<210>  658
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  658
uaacggugcu ccaguagucg u                                                 21


<210>  659
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  659
uacugagaau acugucccug u                                                 21


<210>  660
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  660
uuaacggugc uccaguaggc u                                                 21


<210>  661
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  661
aagccaucgg ucacccagcu u                                                 21


<210>  662
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  662
agaacuuguc cuuaacgguu u                                                 21


<210>  663
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  663
ugcacugaga auacuguccc uu                                                22


<210>  664
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  664
agcacugaga auacuguccc uu                                                22


<210>  665
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  665
cuacuugucc uuaacggugc uu                                                22


<210>  666
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  666
aacuuguccu uaacggugcu c                                                 21


<210>  667
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  667
uacuuguccu uaacggugc                                                    19


<210>  668
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  668
uacuuguccu uaacggugcu cc                                                22


<210>  669
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  669
uacuuguccu uaacggugcu cuu                                               23


<210>  670
<211>  23
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  670
uacuuguccu uaacggugcu cca                                               23


<210>  671
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  671
aacuuguccu uaacggugc                                                    19


<210>  672
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  672
aacuuguccu uaacggugcu cc                                                22


<210>  673
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  673
ugagaauacu gucccuuuug u                                                 21


<210>  674
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  674
agagaauacu gucccuuuug g                                                 21


<210>  675
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  675
ugcaacaaca aggaguacc                                                    19


<210>  676
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  676
agcaacaaca aggaguaccu u                                                 21


<210>  677
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  677
ucugaagcca ucggucaccc a                                                 21


<210>  678
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  678
acugaagcca ucggucaccc a                                                 21


<210>  679
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  679
uggaacugaa gccaucgguc a                                                 21


<210>  680
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  680
uggaacugaa gccaucgguc c                                                 21


<210>  681
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  681
uucuuucagg gaacugaagc c                                                 21


<210>  682
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  682
uuuaacggug cuccaguagu c                                                 21


<210>  683
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  683
uccuuaacgg ugcuccagua g                                                 21


<210>  684
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  684
uuccuuaacg gugcuccagu a                                                 21


<210>  685
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  685
uuccuuaacg gugcuccagu c                                                 21


<210>  686
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  686
uugaggucuc aggcagccac u                                                 21


<210>  687
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  687
uuauugaggu cucaggcagc c                                                 21


<210>  688
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  688
uguauugagg ucucaggcag c                                                 21


<210>  689
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  689
ucacugagaa uacugucccu u                                                 21


<210>  690
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  690
ucuuuuaagc aaccuacagg g                                                 21


<210>  691
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  691
ugagaauacu gucccuuuuc c                                                 21


<210>  692
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  692
ugagaauacu gucccuuuuc u                                                 21


<210>  693
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  693
uucuugucca gcuuuauugg g                                                 21


<210>  694
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  694
uagucuuuca gggaacugaa g                                                 21


<210>  695
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  695
uagucuuuca gggaacugaa c                                                 21


<210>  696
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  696
ucacugagaa uacuguccgu u                                                 21


<210>  697
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  697
uagucuuuca gggaacugac g                                                 21


<210>  698
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  698
uagucuuuca gggaacugag g                                                 21


<210>  699
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  699
uagucuuuca gggaacugac c                                                 21


<210>  700
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  700
uagucuuuca gggaacugag c                                                 21


<210>  701
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  701
agaauacugu cccuuuuagg c                                                 21


<210>  702
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  702
agaauacugu cccuuuuaag g                                                 21


<210>  703
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  703
agaauacugu cccuuuuaag c                                                 21


<210>  704
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  704
ugagaauacu gucccuuugc c                                                 21


<210>  705
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  705
ucacugagaa uacugucccu c                                                 21


<210>  706
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  706
uucuugucca gcuuuauugg c                                                 21


<210>  707
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  707
agaauacugu cccuuuuagg u                                                 21


<210>  708
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  708
agaauacugu cccuuuuacg c                                                 21


<210>  709
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  709
agaauacugu cccuuuuaga c                                                 21


<210>  710
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  710
ucacugagaa uacugucccu g                                                 21


<210>  711
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  711
ucacugagaa uacugucccc u                                                 21


<210>  712
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  712
agugcauccu uggcggucuu u                                                 21


<210>  713
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  713
aguagucuuu cagggaacug a                                                 21


<210>  714
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  714
uguagucuuu cagggaacug a                                                 21


<210>  715
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  715
ucuuaacggu gcuccaguag u                                                 21


<210>  716
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  716
uccuuuuaag caaccuacag g                                                 21


<210>  717
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent antisense strand underlying base sequence

<400>  717
uccuuuuaag caaccuacag c                                                 21


<210>  718
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  718
gcaccguuaa ggacaaguau u                                                 21


<210>  719
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  719
gagcaccguu aaggacaagu a                                                 21


<210>  720
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  720
gcaccguuaa ggacaagua                                                    19


<210>  721
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  721
gcaccguuaa ggacaaguu                                                    19


<210>  722
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  722
ccucaauacc ccaagucca                                                    19


<210>  723
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  723
gaccucaaua ccccaagucc a                                                 21


<210>  724
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  724
gcuucaguuc ccugaaaga                                                    19


<210>  725
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  725
ggcuucaguu cccugaaaga                                                   20


<210>  726
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  726
gaccgauggc uucaguuca                                                    19


<210>  727
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  727
gugaccgaug gcuucaguuc a                                                 21


<210>  728
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  728
ccaaaaggga caguauucuc a                                                 21


<210>  729
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  729
cgcaaaaggg acaguauucu ca                                                22


<210>  730
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  730
gacuacugga gcaccguua                                                    19


<210>  731
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  731
gacuacugga gcacuguua                                                    19


<210>  732
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  732
cgacuacugg agcaccguua                                                   20


<210>  733
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  733
gacuacugga gcaucguua                                                    19


<210>  734
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  734
agggacagua uucucagua                                                    19


<210>  735
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  735
cagggacagu auucucagua                                                   20


<210>  736
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  736
gacuacugga gcaccguuaa                                                   20


<210>  737
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  737
gccuacugga gcaccguuaa                                                   20


<210>  738
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  738
gccuacugga gcacuguuaa                                                   20


<210>  739
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  739
gcugggugac cgauggcua                                                    19


<210>  740
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  740
gcugggugac cgauggcuu                                                    19


<210>  741
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  741
gcugggugac cgaugacua                                                    19


<210>  742
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  742
ccguuaagga caaguucua                                                    19


<210>  743
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  743
caccguuaag gacaaguucu a                                                 21


<210>  744
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  744
accguuaagg acaaguuca                                                    19


<210>  745
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  745
accguuaagg acaaguucu                                                    19


<210>  746
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  746
gcaccguuaa ggacaaguuc a                                                 21


<210>  747
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  747
gguacuccuu guuguugca                                                    19


<210>  748
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  748
cggguacucc uuguuguugc a                                                 21


<210>  749
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  749
cggguacucc uuguuguua                                                    19


<210>  750
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  750
gggacaguau ucucagugca                                                   20


<210>  751
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  751
gggacaguau ucucagugcu                                                   20


<210>  752
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  752
gcaccguuaa ggacaaguuu u                                                 21


<210>  753
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  753
ggagcaccgu uaaggacaag ua                                                22


<210>  754
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  754
gagcaccguu aaggacaagu u                                                 21


<210>  755
<211>  22
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  755
ggagcaccgu uaaggacaag uu                                                22


<210>  756
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  756
aaaagggaca guauucucau u                                                 21


<210>  757
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  757
caaaagggac aguauucuca                                                   20


<210>  758
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  758
ccaaaaggga caguauucuc u                                                 21


<210>  759
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  759
gguacuccuu guuguugcau u                                                 21


<210>  760
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  760
ggguacuccu uguuguugca                                                   20


<210>  761
<211>  19
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  761
gguacuccuu guuguugcu                                                    19


<210>  762
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  762
ugggugaccg auggcuucag a                                                 21


<210>  763
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  763
ugggugaccg auggcuucag u                                                 21


<210>  764
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  764
ugaccgaugg cuucaguucc a                                                 21


<210>  765
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  765
ggaccgaugg cuucaguucc a                                                 21


<210>  766
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  766
ggcuucaguu cccugaaaga a                                                 21


<210>  767
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  767
gacuacugga gcaccguuaa a                                                 21


<210>  768
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  768
cuacuggagc accguuaagg a                                                 21


<210>  769
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  769
uacuggagca ccguuaagga a                                                 21


<210>  770
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  770
gacuggagca ccguuaagga a                                                 21


<210>  771
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  771
aguggcugcc ugagaccuca a                                                 21


<210>  772
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  772
ggcugccuga gaccucaaua a                                                 21


<210>  773
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  773
gcugccugag accucaauac a                                                 21


<210>  774
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  774
aagggacagu auucucagug a                                                 21


<210>  775
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  775
acgggacagu auucucagug a                                                 21


<210>  776
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  776
cccuguaggu ugcuuaaaag a                                                 21


<210>  777
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  777
ggaaaaggga caguauucuc a                                                 21


<210>  778
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  7
<223>  n = inosine (hypoxanthine) 

<400>  778
ggcaaangga caguauucuc a                                                 21


<210>  779
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  10
<223>  n = inosine (hypoxanthine) 

<400>  779
gcuuaaaagn gacaguauuc u                                               21


<210>  780
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  16
<223>  n = inosine (hypoxanthine) 

<400>  780
ugaccgaugg cuucanuucc a                                                 21


<210>  781
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  3
<223>  n = 2-aminoadenine

<400>  781
ggnaaaggga caguauucuc a                                                 21


<210>  782
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2-aminoadenine

<400>  782
ngaaaaggga caguauucuc a                                                 21


<210>  783
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  1, 2
<223>  n = 2-aminoadenine

<400>  783
nnaaaaggga caguauucuc a                                                 21


<210>  784
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  784
cccaauaaag cuggacaaga a                                                 21


<210>  785
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  9
<223>  n = inosine (hypoxanthine) 

<400>  785
gcuuaaaang gacaguauuc u                                                21


<210>  786
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  786
cuucaguucc cugaaagacu a                                                 21


<210>  787
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  787
guucaguucc cugaaagacu a                                                 21


<210>  788
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  9
<223>  n = inosine (hypoxanthine) 

<400>  788
aggguacunc uuguuguugc a                                                21


<210>  789
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  789
gggacaguau ucucagugau u                                                 21


<210>  790
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  1
<223>  n = 2-aminoadenine

<400>  790
nagggacagu auucucagug a                                                 21


<210>  791
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  18
<223>  n = inosine (hypoxanthine) 

<400>  791
gagggacagu auucucanug a                                                 21


<210>  792
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  10
<223>  n = inosine (hypoxanthine) 

<400>  792
cuucaguucn cugaaagacu a                                                21


<210>  793
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  793
cggacaguau ucucagugau u                                                 21


<210>  794
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  8
<223>  n = inosine (hypoxanthine) 

<400>  794
ggcaaagnga caguauucuc a                                                 21


<210>  795
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  795
aggguacucc uuguuguugc a                                                 21


<210>  796
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  796
cuucaguucu cugaaagacu a                                                 21


<210>  797
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  797
cuucaguuuc cugaaagacu a                                                 21


<210>  798
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  798
cgucaguucc cugaaagacu a                                                 21


<210>  799
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  799
ccucaguucc cugaaagacu a                                                 21


<210>  800
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  800
cgucaguucu cugaaagacu a                                                 21


<210>  801
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  801
ggucaguucc cugaaagacu a                                                 21


<210>  802
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  802
gcucaguucc cugaaagacu a                                                 21


<210>  803
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  803
gccuaaaagg gacaguauuc u                                                 21


<210>  804
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  804
ccuuaaaagg gacaguauuc u                                                 21


<210>  805
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  11
<223>  n = inosine (hypoxanthine) 

<400>  805
gcuuaaaagg nacaguauuc u                                                 21


<210>  806
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  9
<223>  n = inosine (hypoxanthine) 

<400>  806
cuucaguunc cugaaagacu a                                               21


<210>  807
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = inosine (hypoxanthine) 

<400>  807
aggguacucc uuguuguunc a                                               21


<210>  808
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = inosine (hypoxanthine) 

<400>  808
cuucaguucc cugaaaganu a                                               21


<210>  809
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  20
<223>  n = inosine (hypoxanthine) 

<400>  809
gcuuaaaagg gacaguauun u                                                 21


<210>  810
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  20
<223>  n = inosine (hypoxanthine) 

<400>  810
ggcaaaggga caguauucun a                                                21


<210>  811
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  19
<223>  n = inosine (hypoxanthine) 

<400>  811
gccaauaaag cuggacaana a                                                21


<210>  812
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  10
<223>  n = inosine (hypoxanthine) 

<400>  812
aggguacucn uuguuguugc a                                                21


<210>  813
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  11
<223>  n = inosine (hypoxanthine) 

<400>  813
cuucaguucc nugaaagacu a                                               21


<210>  814
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  11
<223>  n = inosine (hypoxanthine) 

<400>  814
ggcaaaggga naguauucuc a                                               21


<210>  815
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  9, 20
<223>  n = inosine (hypoxanthine) 

<400>  815
gagggacanu auucucagun a                                                21


<210>  816
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  11
<223>  n = inosine (hypoxanthine) 

<400>  816
gccaauaaag nuggacaaga a                                                21


<210>  817
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  10
<223>  n = inosine (hypoxanthine)

<400>  817
gcuuaaaagn gacaguauuc u                                                 21


<210>  818
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  11
<223>  n = inosine (hypoxanthine)

<400>  818
gccuaaaagg nacaguauuc u                                                 21


<210>  819
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  819
accuaaaagg gacaguauuc u                                                 21


<210>  820
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  820
gcguaaaagg gacaguauuc u                                                 21


<210>  821
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  821
gucuaaaagg gacaguauuc u                                                 21


<210>  822
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  18
<223>  n = inosine (hypoxanthine)

<400>  822
gggacaguau ucucagunau u                                                21


<210>  823
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  13
<223>  n = inosine (hypoxanthine)

<400>  823
gccaauaaag cungacaaga a                                                 21


<210>  824
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  9
<223>  n = inosine (hypoxanthine)

<400>  824
gcuuaaaang gacaguauuc u                                                 21


<210>  825
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  825
cagggacagu auucucagug a                                                 21


<210>  826
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  826
aggggacagu auucucagug a                                                 21


<210>  827
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  20
<223>  n = inosine (hypoxanthine)

<400>  827
aggggacagu auucucagun a                                                 21


<210>  828
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  828
agaccgccaa ggaugcacuu u                                                 21


<210>  829
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  15
<223>  n = inosine (hypoxanthine)

<400>  829
agaccgccaa ggauncacuu u                                                21


<210>  830
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  830
ucaguucccu gaaagacuac u                                                 21


<210>  831
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  831
ucaguucccu gaaagacuac a                                                 21


<210>  832
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  15
<223>  n = inosine (hypoxanthine)

<400>  832
acuacuggag caccnuuaag a                                                21


<210>  833
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  833
ccuguagguu gcuuaaaagg a                                                 21


<210>  834
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  834
gcuguagguu gcuuaaaagg a                                                 21


<210>  835
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<400>  835
ggucaguucu cugaaagacu a                                                 21


<210>  836
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  14
<223>  n = inosine (hypoxanthine)

<400>  836
gccaauaaag cugnacaaga a                                                 21


<210>  837
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  RNAi agent sense strand underlying base sequence

<220>
<221>  modified_base
<222>  20
<223>  n = inosine (hypoxanthine)

<400>  837
cagggacagu auucucagun a                                                 21