                         SEQUENCE LISTING

<110>  Mab Discovery GmbH
 
<120>  Agonistic CD40 antibodies

<130>  B198-0013EP1

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  1

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Phe Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 
        35                  40                  45              


Val Ser Cys Ile Tyr Thr Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Ile Asp Asn Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ser Ser Gly Val Ser Tyr Pro Ser Tyr Phe His Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  2

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Cys Ile Tyr Thr Asn Ser Gly Val Thr Tyr Tyr Ala Asn Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Ile Tyr Asn Asp Tyr Asp Tyr Ala Phe Tyr Tyr 
            100                 105                 110         


Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  3
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  3

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Asn Ser Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ala Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Ile Thr Arg Leu Pro Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  4
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  4

Glu Val Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ala Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Val Thr Arg Leu Pro Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  5

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Thr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Ile Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Leu Ser Arg Phe Ser Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  6

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Thr Asn 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Ser Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Tyr Thr Tyr Leu Thr Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  7

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Val Thr Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Ala Thr Tyr Leu Thr Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Ala Thr Tyr Ile Thr Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  9

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Tyr Ala Gly Ser Asn Gly Asn Thr Asp Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Ala Ser Tyr Phe Thr Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  10

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Cys Ile Ala Ala Gly Ser Ser Ile Ile Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Leu Ser Arg Phe Ala Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  11

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 
        35                  40                  45              


Val Ala Cys Tyr Ser Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Ala Asp Tyr Ser Ala Gly Ala Ala Ala Phe Asn Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  12
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  12

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          


Tyr Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 
        35                  40                  45              


Val Ala Cys Phe Ala Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Ala Asp Tyr Ser Gly Gly Ala Ala Ala Phe Asn Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  13

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          


Phe Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Cys Ile Gly Pro Gly Val Ser Gly Asp Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Gly Asp Thr Ser Lys Thr Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gly Val Asp Tyr Thr Tyr Gly Asp Ala Gly Ala Ala 
            100                 105                 110         


Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  14
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  14

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          


Phe Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Cys Phe Ala Asn His Asp Asp Ser Ile Tyr Tyr Ala Gly Trp 
    50                  55                  60                  


Met Asn Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Thr Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Val Asp Tyr Thr Val Gly Tyr Gly Gly Ala Ala Phe 
            100                 105                 110         


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Lys Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr His Cys Gln Thr Tyr Tyr Tyr Ser Ser Ser 
                85                  90                  95      


Ser Ser Tyr Asp Tyr Gly Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110         


<210>  16
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Gly Ser Ser Ser 
                85                  90                  95      


Ile Ser Tyr Asn Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  17
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Gly Ser Thr 
                85                  90                  95      


Thr Ile Ser Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  18
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Val Tyr Gly Ser Ser 
                85                  90                  95      


Thr Ile Ser Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  19
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Gly Asp Tyr Tyr Gly Ser 
                85                  90                  95      


Ser Tyr Val Val Ala Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  20
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Ser Ile Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Tyr Thr Asp Tyr Gly Ser 
                85                  90                  95      


Ser Tyr Val Ser Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Tyr Ser Gly Thr 
                85                  90                  95      


Thr Tyr Asp Ser Thr Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110         


<210>  22
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Tyr Ser Thr Thr 
                85                  90                  95      


Thr Thr Thr Tyr Asp Ser Ser Ala Phe Gly Gln Gly Thr Lys Val Val 
            100                 105                 110         


Ile Lys 
        


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  23

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Val Val Ser Asn 
            20                  25                  30          


Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Leu Ala Ser Thr Leu Pro Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Tyr Lys Ser Ser 
                85                  90                  95      


Ser Thr Asp Gly Thr Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110         


<210>  24
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ser Ser Ser Ser 
                85                  90                  95      


Tyr Val Ser Asn Gly Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  25
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Gly Asn Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asp Tyr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Glu Tyr Asn Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  26
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asp Tyr Tyr Gly Ser Ser Thr 
                85                  90                  95      


Glu Tyr Asn Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 110 


<210>  27
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  27

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Ile Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Thr Tyr Tyr Ser Ser Arg Thr 
                85                  90                  95      


Tyr Ser Tyr Gly Ser Pro Asn Ala Phe Gly Gln Gly Thr Lys Val Val 
            100                 105                 110         


Ile Lys 
        


<210>  28
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  28

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Gly Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Thr Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Arg Asp Ser Ser 
                85                  90                  95      


Ser Ser Ala Phe Gly Gln Gly Thr Lys Val Val Ile Lys 
            100                 105                 


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  29

Phe Ser Tyr Trp Ile Cys 
1               5       


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  30

Gly Tyr Trp Met Cys 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  31

Ser Asn Ala Met Ser 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  32

Ser Asn Ala Met Ser 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequences

<400>  33

Ser Asn Thr Met Cys 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  34

Thr Asn Ala Val Ser 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  35

Ser Asn Ala Met Ser 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  36

Ser Asn Ala Met Ser 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  37

Ser Asn Ala Met Ser 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  38

Thr Asn Ala Met Cys 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  39

Arg Tyr Tyr Tyr Met Cys 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  40

Arg Tyr Tyr Tyr Ile Cys 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  41

Arg Tyr Phe Tyr Met Cys 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  42

Arg Tyr Phe Tyr Val Cys 
1               5       


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  43

Cys Ile Tyr Thr Thr Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  44

Cys Ile Tyr Thr Asn Ser Gly Val Thr Tyr Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  45

Ser Ile Tyr Ala Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  46

Ser Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  47

Cys Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  48
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  48

Ser Ile Ser Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  49
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  49

Thr Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  50
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  50

Ile Ile Tyr Ala Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  51

Thr Ile Tyr Ala Gly Ser Asn Gly Asn Thr Asp Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  52

Cys Ile Ala Ala Gly Ser Ser Ile Ile Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  53

Cys Tyr Ser Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  54

Cys Phe Ala Asn Gly Asp Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  55

Cys Ile Gly Pro Gly Val Ser Gly Asp Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  56

Cys Phe Ala Asn His Asp Asp Ser Ile Tyr Tyr Ala Gly Trp Met Asn 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  57

Ser Ser Gly Val Ser Tyr Pro Ser Tyr Phe His Leu 
1               5                   10          


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  58

Gly Gly Ala Ile Tyr Asn Asp Tyr Asp Tyr Ala Phe Tyr Tyr Ser Leu 
1               5                   10                  15      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  59

Gly Ile Thr Arg Leu Pro Leu 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  60

Gly Val Thr Arg Leu Pro Leu 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  61

Gly Leu Ser Arg Phe Ser Leu 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  62

Gly Tyr Thr Tyr Leu Thr Leu 
1               5           


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  63

Gly Ala Thr Tyr Leu Thr Leu 
1               5           


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  64

Gly Ala Thr Tyr Ile Thr Leu 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  65

Gly Ala Ser Tyr Phe Thr Leu 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  66

Gly Leu Ser Arg Phe Ala Leu 
1               5           


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  67

Gly Ala Asp Tyr Ser Ala Gly Ala Ala Ala Phe Asn Leu 
1               5                   10              


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  68

Gly Ala Asp Tyr Ser Gly Gly Ala Ala Ala Phe Asn Leu 
1               5                   10              


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  69

Gly Val Asp Tyr Thr Tyr Gly Asp Ala Gly Ala Ala Phe Asn Leu 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  70

Gly Val Asp Tyr Thr Val Gly Tyr Gly Gly Ala Ala Phe Asn Leu 
1               5                   10                  15  


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  71

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  72

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  73

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  74

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  75
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  75

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  76
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  76

Gln Ala Ser His Ser Ile Ser Ser Thr Tyr Leu Ser 
1               5                   10          


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  77

Gln Ala Ser Gln Ser Ile Ser Asn Tyr Leu Ser 
1               5                   10      


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  78

Gln Ala Ser Gln Ser Ile Gly Ser Tyr Leu Ala 
1               5                   10      


<210>  79
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  79

Gln Ala Ser Glu Ser Val Val Ser Asn Asn Arg Leu Ala 
1               5                   10              


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  80

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  81

Gln Ala Ser Glu Ser Ile Gly Asn Ala Leu Val 
1               5                   10      


<210>  82
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  82

Gln Ala Ser Gln Ser Ile Ser Ser Arg Leu Ala 
1               5                   10      


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  83

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  84

Gln Ala Ser Gln Ser Ile Gly Ser Tyr Leu Ser 
1               5                   10      


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  85

Ser Ala Ser Lys Leu Pro Ser 
1               5           


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  86

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  87

Asp Ala Ser Lys Leu Ala Ser 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  88

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  89

Asp Ala Ser Lys Leu Ala Ser 
1               5           


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  90

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  91

Arg Ala Ser Thr Leu Pro Ser 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  92

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  93

Leu Ala Ser Thr Leu Pro Ser 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  94

Leu Thr Ser Thr Leu Ala Ser 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  95

Arg Ala Ser Ile Leu Ala Ser 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  96

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  97

Arg Ala Ser Ile Leu Ala Ser 
1               5           


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  98

Arg Ala Thr Thr Leu Ala Ser 
1               5           


<210>  99
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  99

Gln Thr Tyr Tyr Tyr Ser Ser Ser Ser Ser Tyr Asp Tyr Gly 
1               5                   10                  


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  100

Gln Ser Tyr Tyr Gly Ser Ser Ser Ile Ser Tyr Asn Ala 
1               5                   10              


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  101

Gln Gly Thr Tyr Tyr Gly Ser Thr Thr Ile Ser Ala 
1               5                   10          


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  102

Gln Gly Thr Val Tyr Gly Ser Ser Thr Ile Ser Ala 
1               5                   10          


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  103

Gln Gly Gly Asp Tyr Tyr Gly Ser Ser Tyr Val Val Ala 
1               5                   10              


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  104

Gln Tyr Thr Asp Tyr Gly Ser Ser Tyr Val Ser Thr 
1               5                   10          


<210>  105
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  105

Gln Gly Tyr Tyr Tyr Ser Gly Thr Thr Tyr Asp Ser Thr Ala 
1               5                   10                  


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  106

Gln Gly Tyr Tyr Tyr Ser Thr Thr Thr Thr Thr Tyr Asp Ser Ser Ala 
1               5                   10                  15      


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  107

Ala Gly Tyr Lys Ser Ser Ser Thr Asp Gly Thr Ala 
1               5                   10          


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  108

Gln Gly Tyr Tyr Ser Ser Ser Ser Tyr Val Ser Asn Gly 
1               5                   10              


<210>  109
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  109

Gln Asp Tyr Tyr Gly Ser Ser Thr Glu Tyr Asn Thr 
1               5                   10          


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  110

Gln Asp Tyr Tyr Gly Ser Ser Thr Glu Tyr Asn Ala 
1               5                   10          


<210>  111
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence

<400>  111

Gln Thr Tyr Tyr Ser Ser Arg Thr Tyr Ser Tyr Gly Ser Pro Asn Ala 
1               5                   10                  15      


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  112

Gln Ser Tyr Tyr Arg Asp Ser Ser Ser Ser Ala 
1               5                   10      


