                         SEQUENCE LISTING

<110>  THERACHON
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
       (INSERM)
 
<120>  TREATMENT OF ABNORMAL VISCERAL FAT DEPOSITION USING SOLUBLE 
       FIBROBLAST GROWTH FACTOR RECEPTOR 3 (SFGFR3) POLYPEPTIDES

<130>  51088-011WO2

<150>  US 61/561,140
<151>  2017-09-20

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
    290                 295                 300                 


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
305                 310                 315                 320 


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
                325                 330                 335     


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
            340                 345                 350         


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
        355                 360                 365             


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
    370                 375                 380                 


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
385                 390                 395                 400 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
                405                 410                 415     


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
            420                 425                 430         


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
        435                 440                 445             


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
    450                 455                 460                 


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
465                 470                 475                 480 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
                485                 490                 495     


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
            500                 505                 510         


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
        515                 520                 525             


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
    530                 535                 540                 


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
545                 550                 555                 560 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
                565                 570                 575     


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
            580                 585                 590         


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
        595                 600                 605             


Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp 
    610                 615                 620                 


Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
625                 630                 635                 640 


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala 
                645                 650                 655     


His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
            660                 665                 670         


<210>  2
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3

<400>  2

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
    290                 295                 300                 


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
305                 310                 315                 320 


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
                325                 330                 335     


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
            340                 345                 350         


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
        355                 360                 365             


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
    370                 375                 380                 


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
385                 390                 395                 400 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
                405                 410                 415     


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
            420                 425                 430         


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
        435                 440                 445             


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
    450                 455                 460                 


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
465                 470                 475                 480 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
                485                 490                 495     


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
            500                 505                 510         


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp 
        515                 520                 525     


<210>  3
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFGFR3

<400>  3

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
    290                 295                 300                 


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
305                 310                 315                 320 


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
                325                 330                 335     


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
            340                 345                 350         


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
        355                 360                 365             


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
    370                 375                 380                 


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
385                 390                 395                 400 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
                405                 410                 415     


Leu Tyr 
        


<210>  4
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr 
    290                 295                 300     


<210>  5
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr 
            340                 345                 


<210>  6
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Ser Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr 
    290                 295                 300     


<210>  7
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Ser Gly Ser 
    290                 295                 300                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Val Val Phe Pro 
305                 310                 315                 320 


Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu Ala Gln 
                325                 330                 335     


Gln Ala Cys Leu Asp Gln Asp Ala Val Ile Ala Ser Phe Asp Gln Leu 
            340                 345                 350         


Tyr Asp Ala Trp Arg Gly Gly Leu Asp Trp Cys Asn Ala Gly Trp Leu 
        355                 360                 365             


Ser Asp Gly Ser Val Gln Tyr Pro Ile Thr Lys Pro Arg Glu Pro Cys 
    370                 375                 380                 


Gly Gly Gln Asn Thr Val Pro Gly Val Arg Asn Tyr Gly Phe Trp Asp 
385                 390                 395                 400 


Lys Asp Lys Ser Arg Tyr Asp Val Phe Cys Phe Thr Ser Asn Phe Asn 
                405                 410                 415     


Gly Arg Phe Tyr Tyr Leu Ile His Pro Thr Lys Leu Thr Tyr Asp Glu 
            420                 425                 430         


Ala Val Gln Ala Cys Leu Asn Asp Gly Ala Gln Ile Ala Lys Val Gly 
        435                 440                 445             


Gln Ile Phe Ala Ala Trp Lys Ile Leu Gly Tyr Asp Arg Cys Asp Ala 
    450                 455                 460                 


Gly Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Ser Arg Pro Arg 
465                 470                 475                 480 


Arg Arg Cys Ser Pro Thr Glu Ala Ala Val Arg Phe Val Gly Phe Pro 
                485                 490                 495     


Asp Lys Lys His Lys Leu Tyr Gly Val Tyr Cys Phe Arg Ala Tyr Asn 
            500                 505                 510         


<210>  8
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe Leu Phe Ile Leu Val Val 
        355                 360                 365             


Ala Ala Val Thr Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu 
    370                 375                 380                 


Gly Ser Pro Thr Val His Lys Ile Ser Arg Phe Pro Leu Lys Arg Gln 
385                 390                 395                 400 


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
                405                 410                 415     


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
            420                 425                 430         


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
        435                 440                 445             


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
    450                 455                 460                 


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
465                 470                 475                 480 


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
                485                 490                 495     


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
            500                 505                 510         


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
        515                 520                 525             


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
    530                 535                 540                 


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
545                 550                 555                 560 


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
                565                 570                 575     


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
            580                 585                 590         


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
        595                 600                 605             


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
    610                 615                 620                 


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
625                 630                 635                 640 


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
                645                 650                 655     


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
            660                 665                 670         


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
        675                 680                 685             


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
    690                 695                 700                 


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
705                 710                 715                 720 


Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp 
                725                 730                 735     


Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
            740                 745                 750         


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala 
        755                 760                 765             


His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
    770                 775                 780                 


<210>  9
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Ala Glu Glu Glu Leu Val Glu Ala Asp Glu Ala Gly Ser Val Tyr Ala 
            340                 345                 350         


Gly Ile Leu Ser Tyr Arg Val Gly Phe Phe Leu Phe Ile Leu Val Val 
        355                 360                 365             


Ala Ala Val Thr Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu 
    370                 375                 380                 


Gly Ser Pro Thr Val His Lys Ile Ser Arg Phe Pro Leu Lys Arg Gln 
385                 390                 395                 400 


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
                405                 410                 415     


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
            420                 425                 430         


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
        435                 440                 445             


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
    450                 455                 460                 


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
465                 470                 475                 480 


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
                485                 490                 495     


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
            500                 505                 510         


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
        515                 520                 525             


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
    530                 535                 540                 


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
545                 550                 555                 560 


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
                565                 570                 575     


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
            580                 585                 590         


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
        595                 600                 605             


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
    610                 615                 620                 


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
625                 630                 635                 640 


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
                645                 650                 655     


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
            660                 665                 670         


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
        675                 680                 685             


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
    690                 695                 700                 


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
705                 710                 715                 720 


Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp 
                725                 730                 735     


Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
            740                 745                 750         


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala 
        755                 760                 765             


His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
    770                 775                 780                 


<210>  10
<211>  2016
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10
gagtccttgg ggacggagca gcgcgtcgtg gggcgagcgg cagaagtccc gggcccagag       60

cccggccagc aggagcagtt ggtcttcggc agcggggatg ctgtggagct gagctgtccc      120

ccgcccgggg gtggtcccat ggggcccact gtctgggtca aggatggcac agggctggtg      180

ccctcggagc gtgtcctggt ggggccccag cggctgcagg tgctgaatgc ctcccacgag      240

gactccgggg cctacagctg ccggcagcgg ctcacgcagc gcgtactgtg ccacttcagt      300

gtgcgggtga cagacgctcc atcctcggga gatgacgaag acggggagga cgaggctgag      360

gacacaggtg tggacacagg ggccccttac tggacacggc ccgagcggat ggacaagaag      420

ctgctggccg tgccggccgc caacaccgtc cgcttccgct gcccagccgc tggcaacccc      480

actccctcca tctcctggct gaagaacggc agggagttcc gcggcgagca ccgcattgga      540

ggcatcaagc tgcggcatca gcagtggagc ctggtcatgg aaagcgtggt gccctcggac      600

cgcggcaact acacctgcgt cgtggagaac aagtttggca gcatccggca gacgtacacg      660

ctggacgtgc tggagcgctc cccgcaccgg cccatcctgc aggcggggct gccggccaac      720

cagacggcgg tgctgggcag cgacgtggag ttccactgca aggtgtacag tgacgcacag      780

ccccacatcc agtggctcaa gcacgtggag gtgaatggca gcaaggtggg cccggacggc      840

acaccctacg ttaccgtgct caaggtgtcc ctggagtcca acgcgtccat gagctccaac      900

acaccactgg tgcgcatcgc aaggctgtcc tcaggggagg gccccacgct ggccaatgtc      960

tccgagctcg agctgcctgc cgaccccaaa tgggagctgt ctcgggcccg gctgaccctg     1020

ggcaagcccc ttggggaggg ctgcttcggc caggtggtca tggcggaggc catcggcatt     1080

gacaaggacc gggccgccaa gcctgtcacc gtagccgtga agatgctgaa agacgatgcc     1140

actgacaagg acctgtcgga cctggtgtct gagatggaga tgatgaagat gatcgggaaa     1200

cacaaaaaca tcatcaacct gctgggcgcc tgcacgcagg gcgggcccct gtacgtgctg     1260

gtggagtacg cggccaaggg taacctgcgg gagtttctgc gggcgcggcg gcccccgggc     1320

ctggactact ccttcgacac ctgcaagccg cccgaggagc agctcacctt caaggacctg     1380

gtgtcctgtg cctaccaggt ggcccggggc atggagtact tggcctccca gaagtgcatc     1440

cacagggacc tggctgcccg caatgtgctg gtgaccgagg acaacgtgat gaagatcgca     1500

gacttcgggc tggcccggga cgtgcacaac ctcgactact acaagaagac aaccaacggc     1560

cggctgcccg tgaagtggat ggcgcctgag gccttgtttg accgagtcta cactcaccag     1620

agtgacgtct ggtcctttgg ggtcctgctc tgggagatct tcacgctggg gggctccccg     1680

taccccggca tccctgtgga ggagctcttc aagctgctga aggagggcca ccgcatggac     1740

aagcccgcca actgcacaca cgacctgtac atgatcatgc gggagtgctg gcatgccgcg     1800

ccctcccaga ggcccacctt caagcagctg gtggaggacc tggaccgtgt ccttaccgtg     1860

acgtccaccg acgagtacct ggacctgtcg gcgcctttcg agcagtactc cccgggtggc     1920

caggacaccc ccagctccag ctcctcaggg gacgactccg tgtttgccca cgacctgctg     1980

cccccggccc cacccagcag tgggggctcg cggacg                               2016


<210>  11
<211>  1579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
gagtccttgg ggacggagca gcgcgtcgtg gggcgagcgg cagaagtccc gggcccagag       60

cccggccagc aggagcagtt ggtcttcggc agcggggatg ctgtggagct gagctgtccc      120

ccgcccgggg gtggtcccat ggggcccact gtctgggtca aggatggcac agggctggtg      180

ccctcggagc gtgtcctggt ggggccccag cggctgcagg tgctgaatgc ctcccacgag      240

gactccgggg cctacagctg ccggcagcgg ctcacgcagc gcgtactgtg ccacttcagt      300

gtgcgggtga cagacgctcc atcctcggga gatgacgaag acggggagga cgaggctgag      360

gacacaggtg tggacacagg ggccccttac tggacacggc ccgagcggat ggacaagaag      420

ctgctggccg tgccggccgc caacaccgtc cgcttccgct gcccagccgc tggcaacccc      480

actccctcca tctcctggct gaagaacggc agggagttcc gcggcgagca ccgcattgga      540

ggcatcaagc tgcggcatca gcagtggagc ctggtcatgg aaagcgtggt gccctcggac      600

cgcggcaact acacctgcgt cgtggagaac aagtttggca gcatccggca gacgtacacg      660

ctggacgtgc tggagcgctc cccgcaccgg cccatcctgc aggcggggct gccggccaac      720

cagacggcgg tgctgggcag cgacgtggag ttccactgca aggtgtacag tgacgcacag      780

ccccacatcc agtggctcaa gcacgtggag gtgaatggca gcaaggtggg cccggacggc      840

acaccctacg ttaccgtgct caaggtgtcc ctggagtcca acgcgtccat gagctccaac      900

acaccactgg tgcgcatcgc aaggctgtcc tcaggggagg gccccacgct ggccaatgtc      960

tccgagctcg agctgcctgc cgaccccaaa tgggagctgt ctcgggcccg gctgaccctg     1020

ggcaagcccc ttggggaggg ctgcttcggc caggtggtca tggcggaggc catcggcatt     1080

gacaaggacc gggccgccaa gcctgtcacc gtagccgtga agatgctgaa agacgatgcc     1140

actgacaagg acctgtcgga cctggtgtct gagatggaga tgatgaagat gatcgggaaa     1200

cacaaaaaca tcatcaacct gctgggcgcc tgcacgcagg gcgggcccct gtacgtgctg     1260

gtggagtacg cggccaaggg taacctgcgg gagtttctgc gggcgcggcg gcccccgggc     1320

ctggactact ccttcgacac ctgcaagccg cccgaggagc agctcacctt caaggacctg     1380

gtgtcctgtg cctaccaggt ggcccggggc atggagtact tggcctccca gaagtgcatc     1440

cacagggacc tggctgcccg caatgtgctg gtgaccgagg acaacgtgat gaagatcgca     1500

gacttcgggc tggcccggga cgtgcacaac ctcgactact acaagaagac aaccaacggc     1560

cggctgcccg tgaagtgga                                                  1579


<210>  12
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12
gagtccttgg ggacggagca gcgcgtcgtg gggcgagcgg cagaagtccc gggcccagag       60

cccggccagc aggagcagtt ggtcttcggc agcggggatg ctgtggagct gagctgtccc      120

ccgcccgggg gtggtcccat ggggcccact gtctgggtca aggatggcac agggctggtg      180

ccctcggagc gtgtcctggt ggggccccag cggctgcagg tgctgaatgc ctcccacgag      240

gactccgggg cctacagctg ccggcagcgg ctcacgcagc gcgtactgtg ccacttcagt      300

gtgcgggtga cagacgctcc atcctcggga gatgacgaag acggggagga cgaggctgag      360

gacacaggtg tggacacagg ggccccttac tggacacggc ccgagcggat ggacaagaag      420

ctgctggccg tgccggccgc caacaccgtc cgcttccgct gcccagccgc tggcaacccc      480

actccctcca tctcctggct gaagaacggc agggagttcc gcggcgagca ccgcattgga      540

ggcatcaagc tgcggcatca gcagtggagc ctggtcatgg aaagcgtggt gccctcggac      600

cgcggcaact acacctgcgt cgtggagaac aagtttggca gcatccggca gacgtacacg      660

ctggacgtgc tggagcgctc cccgcaccgg cccatcctgc aggcggggct gccggccaac      720

cagacggcgg tgctgggcag cgacgtggag ttccactgca aggtgtacag tgacgcacag      780

ccccacatcc agtggctcaa gcacgtggag gtgaatggca gcaaggtggg cccggacggc      840

acaccctacg ttaccgtgct caaggtgtcc ctggagtcca acgcgtccat gagctccaac      900

acaccactgg tgcgcatcgc aaggctgtcc tcaggggagg gccccacgct ggccaatgtc      960

tccgagctcg agctgcctgc cgaccccaaa tgggagctgt ctcgggcccg gctgaccctg     1020

ggcaagcccc ttggggaggg ctgcttcggc caggtggtca tggcggaggc catcggcatt     1080

gacaaggacc gggccgccaa gcctgtcacc gtagccgtga agatgctgaa agacgatgcc     1140

actgacaagg acctgtcgga cctggtgtct gagatggaga tgatgaagat gatcgggaaa     1200

cacaaaaaca tcatcaacct gctgggcgcc tgcacgcagg gcgggcccct gtac           1254


<210>  13
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
gagtccttgg ggacggagca gcgcgtcgtg gggcgagcgg cagaagtccc gggcccagag       60

cccggccagc aggagcagtt ggtcttcggc agcggggatg ctgtggagct gagctgtccc      120

ccgcccgggg gtggtcccat ggggcccact gtctgggtca aggatggcac agggctggtg      180

ccctcggagc gtgtcctggt ggggccccag cggctgcagg tgctgaatgc ctcccacgag      240

gactccgggg cctacagctg ccggcagcgg ctcacgcagc gcgtactgtg ccacttcagt      300

gtgcgggtga cagacgctcc atcctcggga gatgacgaag acggggagga cgaggctgag      360

gacacaggtg tggacacagg ggccccttac tggacacggc ccgagcggat ggacaagaag      420

ctgctggccg tgccggccgc caacaccgtc cgcttccgct gcccagccgc tggcaacccc      480

actccctcca tctcctggct gaagaacggc agggagttcc gcggcgagca ccgcattgga      540

ggcatcaagc tgcggcatca gcagtggagc ctggtcatgg aaagcgtggt gccctcggac      600

cgcggcaact acacctgcgt cgtggagaac aagtttggca gcatccggca gacgtacacg      660

ctggacgtgc tggagcgctc cccgcaccgg cccatcctgc aggcggggct gccggccaac      720

cagacggcgg tgctgggcag cgacgtggag ttccactgca aggtgtacag tgacgcacag      780

ccccacatcc agtggctcaa gcacgtggag gtgaatggca gcaaggtggg cccggacggc      840

acaccctacg ttaccgtgct caaggtgtcc ctggagtcca acgcgtccat gagctccaac      900

aca                                                                    903


<210>  14
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
atgggagtga aggtgctgtt cgccctgatc tgtatcgccg tggccgaggc cgagtctctg       60

ggcacagaac agagagtcgt gggcagagcc gccgaagtgc ctggacctga acctggccag      120

caggaacagc tggtgtttgg cagcggcgac gccgtggaac tgagctgtcc tccacctggc      180

ggaggcccta tgggacctac cgtgtgggtc aaggatggca ccggactggt gcctagcgag      240

agggtgctcg tgggacctca gagactgcag gtgctgaacg ccagccacga ggatagcggc      300

gcctacagct gcagacagag actgacacag cgggtgctgt gccacttctc cgtcagagtg      360

accgacgccc ctagctccgg cgacgatgag gatggcgaag atgaggccga ggacaccggc      420

gtggacacag gcgctccata ctggaccaga cccgagcgga tggacaagaa actgctggcc      480

gtgcctgccg ccaacaccgt gcggtttaga tgtcctgccg ccggaaaccc cacccccagc      540

atcagctggc tgaagaacgg cagagagttc cggggcgagc acagaatcgg cggcatcaag      600

ctgagacacc agcagtggtc cctcgtgatg gaaagcgtgg tgcccagcga ccggggcaac      660

tacacctgtg tggtggaaaa caagttcggc agcatccggc agacctacac cctggacgtg      720

ctggaaagaa gcccccacag acccatcctg caggccggac tgcctgccaa tcagacagcc      780

gtgctgggca gcgacgtgga atttcactgc aaggtgtaca gcgacgccca gccccacatc      840

cagtggctga aacacgtgga agtgaacggc agcaaagtgg gccccgacgg caccccttat      900

gtgaccgtgc tgaaaaccgc tggcgccaat accaccgaca aagaactgga agtgctgagc      960

ctgcacaacg tgaccttcga ggatgccggc gagtacacct gtctggccgg caacagcatc     1020

ggcttcagcc accattctgc ctggctggtg gtgctgcccg tgtccctgga aagcaacgcc     1080

agcatgagca gcaacaccga ctacaaggac gacgacgaca agtgaaagct t              1131


<210>  15
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggccgag       60

tccttgggga cggagcagcg cgtcgtgggg cgagcggcag aagtcccggg cccagagccc      120

ggccagcagg agcagttggt cttcggcagc ggggatgctg tggagctgag ctgtcccccg      180

cccgggggtg gtcccatggg gcccactgtc tgggtcaagg atggcacagg gctggtgccc      240

tcggagcgtg tcctggtggg gccccagcgg ctgcaggtgc tgaatgcctc ccacgaggac      300

tccggggcct acagctgccg gcagcggctc acgcagcgcg tactgtgcca cttcagtgtg      360

cgggtgacag acgctccatc ctcgggagat gacgaagacg gggaggacga ggctgaggac      420

acaggtgtgg acacaggggc cccttactgg acacggcccg agcggatgga caagaagctg      480

ctggccgtgc cggccgccaa caccgtccgc ttccgctgcc cagccgctgg caaccccact      540

ccctccatct cctggctgaa gaacggcagg gagttccgcg gcgagcaccg cattggaggc      600

atcaagctgc ggcatcagca gtggagcctg gtcatggaaa gcgtggtgcc ctcggaccgc      660

ggcaactaca cctgcgtcgt ggagaacaag tttggcagca tccggcagac gtacacgctg      720

gacgtgctgg agcgctcccc gcaccggccc atcctgcagg ctgggctgcc tgctaaccag      780

acagcggtgc tgggcagcga cgtggagttc cactgcaagg tgtacagtga cgcacagccc      840

cacatccagt ggctcaagca cgtggaggtg aatggcagca aggtgggccc ggacggcaca      900

ccctacgtta ccgtgctcaa gacggcgggc gctaacacca ccgacaagga gctagaggtt      960

ctctccttgc acaacgtcac ctttgaggac gccggggagt acacctgcct ggcgggcaat     1020

tctattgggt tttctcatca ctctgcgtgg ctggtggtgc tgccagtgtc cctggagtcc     1080

aacgcgtcca tgagctccaa cacatga                                         1107


<210>  16
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
atgggagtga aggtgctgtt cgccctgatc tgtatcgccg tggccgaggc cgagtctctg       60

ggcacagaac agagagtcgt gggcagagcc gccgaagtgc ctggacctga acctggccag      120

caggaacagc tggtgtttgg cagcggcgac gccgtggaac tgagctgtcc tccacctggc      180

ggaggcccta tgggacctac cgtgtgggtc aaggatggca ccggactggt gcctagcgag      240

agggtgctcg tgggacctca gagactgcag gtgctgaacg ccagccacga ggatagcggc      300

gcctacagct gcagacagag actgacacag cgggtgctgt gccacttctc cgtcagagtg      360

accgacgccc ctagctccgg cgacgatgag gatggcgaag atgaggccga ggacaccggc      420

gtggacacag gcgctccata ctggaccaga cccgagcgga tggacaagaa actgctggcc      480

gtgcctgccg ccaacaccgt gcggtttaga tgtcctgccg ccggaaaccc cacccccagc      540

atcagctggc tgaagaacgg cagagagttc cggggcgagc acagaatcgg cggcatcaag      600

ctgagacacc agcagtggtc cctcgtgatg gaaagcgtgg tgcccagcga ccggggcaac      660

tacacctgtg tggtggaaaa caagttcggc agcatccggc agacctacac cctggacgtg      720

ctggaaagaa gcccccacag acccatcctg caggccggac tgcctgccaa tcagacagcc      780

gtgctgggca gcgacgtgga atttcacagc aaggtgtaca gcgacgccca gccccacatc      840

cagtggctga aacacgtgga agtgaacggc agcaaagtgg gccccgacgg caccccttat      900

gtgaccgtgc tgaaggtgtc cctggaaagc aacgccagca tgagcagcaa caccgactac      960

aaggacgacg acgacaagtg aaagctt                                          987


<210>  17
<211>  1107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
atgatgtcct ttgtctctct gctcctggtt ggcatcctat tccatgccac ccaggccgag       60

tccttgggga cggagcagcg cgtcgtgggg cgagcggcag aagtcccggg cccagagccc      120

ggccagcagg agcagttggt cttcggcagc ggggatgctg tggagctgag ctgtcccccg      180

cccgggggtg gtcccatggg gcccactgtc tgggtcaagg atggcacagg gctggtgccc      240

tcggagcgtg tcctggtggg gccccagcgg ctgcaggtgc tgaatgcctc ccacgaggac      300

tccggggcct acagctgccg gcagcggctc acgcagcgcg tactgtgcca cttcagtgtg      360

cgggtgacag acgctccatc ctcgggagat gacgaagacg gggaggacga ggctgaggac      420

acaggtgtgg acacaggggc cccttactgg acacggcccg agcggatgga caagaagctg      480

ctggccgtgc cggccgccaa caccgtccgc ttccgctgcc cagccgctgg caaccccact      540

ccctccatct cctggctgaa gaacggcagg gagttccgcg gcgagcaccg cattggaggc      600

atcaagctgc ggcatcagca gtggagcctg gtcatggaaa gcgtggtgcc ctcggaccgc      660

ggcaactaca cctgcgtcgt ggagaacaag tttggcagca tccggcagac gtacacgctg      720

gacgtgctgg agcgctcccc gcaccggccc atcctgcagg ctgggctgcc tgctaaccag      780

acagcggtgc tgggcagcga cgtggagttc cactgcaagg tgtacagtga cgcacagccc      840

cacatccagt ggctcaagca cgtggaggtg aatggcagca aggtgggccc ggacggcaca      900

ccctacgtta ccgtgctcaa gacggcgggc gctaacacca ccgacaagga gctagaggtt      960

ctctccttgc acaacgtcac ctttgaggac gccggggagt acacctgcct ggcgggcaat     1020

tctattgggt tttctcatca ctctgcgtgg ctggtggtgc tgccagtgtc cctggagtcc     1080

aacgcgtcca tgagctccaa cacatga                                         1107


<210>  18
<211>  1548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
gagagcctgg gcacagagca gcgggtggtg ggaagggccg ctgaagtgcc tggccctgag       60

cctggccagc aggaacagct ggtctttggc agcggcgacg ccgtggaact gagctgtcct      120

ccacccggcg gaggccctat gggccctacc gtgtgggtga aagacggcac cggcctggtg      180

cccagcgaga gggtgctggt gggaccccag cggctgcagg tcctgaacgc cagccacgag      240

gacagcggcg cctacagctg cagacagaga ctgacccagc gggtgctgtg ccacttcagc      300

gtgcgcgtga ccgacgcccc tagctctggc gacgacgagg acggcgagga cgaggccgag      360

gataccggcg tggacacagg cgccccttac tggaccagac ccgagcggat ggacaagaaa      420

ctgctggccg tgcctgccgc caacaccgtg cggttcagat gtcccgccgc tggcaacccc      480

acccccagca tcagctggct gaagaacggc agagagttcc ggggcgagca ccggatcggc      540

ggcatcaagc tgcggcacca gcagtggtcc ctggtcatgg aaagcgtggt gccctccgac      600

cggggcaact acacctgtgt ggtggaaaac aagttcggca gcatccggca gacctacacc      660

ctggacgtgc tggaaagaag cccccaccgg cccatcctgc aggctggact gcccgccaat      720

cagacagccg tgctgggcag cgacgtggaa tttcactgca aggtgtacag cgacgcccag      780

ccccacatcc agtggctcaa gcacgtggaa gtgaacggca gcaaagtggg ccccgacggc      840

accccttacg tgaccgtgct gaaagtgtcc ctggaaagca acgccagcat gagcagcaac      900

acctgaggta ccagcggcag cggctctggc tctggaagcg gaagcggatc tgggagcgtg      960

gtgttcccct acttcccccg gctgggccgg tacaacctga acttccacga ggcccagcag     1020

gcttgcctcg accaggatgc cgtgatcgcc agcttcgacc agctgtacga tgcctggcgg     1080

ggaggcctgg actggtgcaa tgccggctgg ctgtccgacg gcagcgtcca gtaccccatc     1140

accaagccca gagagccctg cggcggacag aacacagtgc ccggcgtgcg gaactacggc     1200

ttctgggaca aggacaagag cagatacgac gtgttctgct tcaccagcaa cttcaacggc     1260

cggttctact acctgatcca ccccaccaag ctgacctacg acgaagccgt ccaggcctgt     1320

ctgaacgacg gcgcccagat cgccaaagtg ggacagatct tcgccgcctg gaagatcctg     1380

ggctacgaca gatgcgacgc cggatggctg gccgatggct ccgtgcgcta ccctatcagc     1440

agaccccgca gaagatgcag ccctaccgag gccgccgtgc gcttcgtggg cttccccgac     1500

aagaagcaca agctgtacgg cgtctactgc ttccgggcct acaactga                  1548


<210>  19
<211>  2355
<212>  DNA
<213>  Homo sapiens

<400>  19
gagtccttgg ggacggagca gcgcgtcgtg gggcgagcgg cagaagtccc gggcccagag       60

cccggccagc aggagcagtt ggtcttcggc agcggggatg ctgtggagct gagctgtccc      120

ccgcccgggg gtggtcccat ggggcccact gtctgggtca aggatggcac agggctggtg      180

ccctcggagc gtgtcctggt ggggccccag cggctgcagg tgctgaatgc ctcccacgag      240

gactccgggg cctacagctg ccggcagcgg ctcacgcagc gcgtactgtg ccacttcagt      300

gtgcgggtga cagacgctcc atcctcggga gatgacgaag acggggagga cgaggctgag      360

gacacaggtg tggacacagg ggccccttac tggacacggc ccgagcggat ggacaagaag      420

ctgctggccg tgccggccgc caacaccgtc cgcttccgct gcccagccgc tggcaacccc      480

actccctcca tctcctggct gaagaacggc agggagttcc gcggcgagca ccgcattgga      540

ggcatcaagc tgcggcatca gcagtggagc ctggtcatgg aaagcgtggt gccctcggac      600

cgcggcaact acacctgcgt cgtggagaac aagtttggca gcatccggca gacgtacacg      660

ctggacgtgc tggagcgctc cccgcaccgg cccatcctgc aggcggggct gccggccaac      720

cagacggcgg tgctgggcag cgacgtggag ttccactgca aggtgtacag tgacgcacag      780

ccccacatcc agtggctcaa gcacgtggag gtgaatggca gcaaggtggg cccggacggc      840

acaccctacg ttaccgtgct caagacggcg ggcgctaaca ccaccgacaa ggagctagag      900

gttctctcct tgcacaacgt cacctttgag gacgccgggg agtacacctg cctggcgggc      960

aattctattg ggttttctca tcactctgcg tggctggtgg tgctgccagc cgaggaggag     1020

ctggtggagg ctgacgaggc gggcagtgtg tatgcaggca tcctcagcta cggggtgggc     1080

ttcttcctgt tcatcctggt ggtggcggct gtgacgctct gccgcctgcg cagccccccc     1140

aagaaaggcc tgggctcccc caccgtgcac aagatctccc gcttcccgct caagcgacag     1200

gtgtccctgg agtccaacgc gtccatgagc tccaacacac cactggtgcg catcgcaagg     1260

ctgtcctcag gggagggccc cacgctggcc aatgtctccg agctcgagct gcctgccgac     1320

cccaaatggg agctgtctcg ggcccggctg accctgggca agccccttgg ggagggctgc     1380

ttcggccagg tggtcatggc ggaggccatc ggcattgaca aggaccgggc cgccaagcct     1440

gtcaccgtag ccgtgaagat gctgaaagac gatgccactg acaaggacct gtcggacctg     1500

gtgtctgaga tggagatgat gaagatgatc gggaaacaca aaaacatcat caacctgctg     1560

ggcgcctgca cgcagggcgg gcccctgtac gtgctggtgg agtacgcggc caagggtaac     1620

ctgcgggagt ttctgcgggc gcggcggccc ccgggcctgg actactcctt cgacacctgc     1680

aagccgcccg aggagcagct caccttcaag gacctggtgt cctgtgccta ccaggtggcc     1740

cggggcatgg agtacttggc ctcccagaag tgcatccaca gggacctggc tgcccgcaat     1800

gtgctggtga ccgaggacaa cgtgatgaag atcgcagact tcgggctggc ccgggacgtg     1860

cacaacctcg actactacaa gaagacaacc aacggccggc tgcccgtgaa gtggatggcg     1920

cctgaggcct tgtttgaccg agtctacact caccagagtg acgtctggtc ctttggggtc     1980

ctgctctggg agatcttcac gctggggggc tccccgtacc ccggcatccc tgtggaggag     2040

ctcttcaagc tgctgaagga gggccaccgc atggacaagc ccgccaactg cacacacgac     2100

ctgtacatga tcatgcggga gtgctggcat gccgcgccct cccagaggcc caccttcaag     2160

cagctggtgg aggacctgga ccgtgtcctt accgtgacgt ccaccgacga gtacctggac     2220

ctgtcggcgc ctttcgagca gtactccccg ggtggccagg acacccccag ctccagctcc     2280

tcaggggacg actccgtgtt tgcccacgac ctgctgcccc cggccccacc cagcagtggg     2340

ggctcgcgga cgtga                                                      2355


<210>  20
<211>  2355
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1073)..(1073)
<223>  N is a or c

<400>  20
gagtccttgg ggacggagca gcgcgtcgtg gggcgagcgg cagaagtccc gggcccagag       60

cccggccagc aggagcagtt ggtcttcggc agcggggatg ctgtggagct gagctgtccc      120

ccgcccgggg gtggtcccat ggggcccact gtctgggtca aggatggcac agggctggtg      180

ccctcggagc gtgtcctggt ggggccccag cggctgcagg tgctgaatgc ctcccacgag      240

gactccgggg cctacagctg ccggcagcgg ctcacgcagc gcgtactgtg ccacttcagt      300

gtgcgggtga cagacgctcc atcctcggga gatgacgaag acggggagga cgaggctgag      360

gacacaggtg tggacacagg ggccccttac tggacacggc ccgagcggat ggacaagaag      420

ctgctggccg tgccggccgc caacaccgtc cgcttccgct gcccagccgc tggcaacccc      480

actccctcca tctcctggct gaagaacggc agggagttcc gcggcgagca ccgcattgga      540

ggcatcaagc tgcggcatca gcagtggagc ctggtcatgg aaagcgtggt gccctcggac      600

cgcggcaact acacctgcgt cgtggagaac aagtttggca gcatccggca gacgtacacg      660

ctggacgtgc tggagcgctc cccgcaccgg cccatcctgc aggcggggct gccggccaac      720

cagacggcgg tgctgggcag cgacgtggag ttccactgca aggtgtacag tgacgcacag      780

ccccacatcc agtggctcaa gcacgtggag gtgaatggca gcaaggtggg cccggacggc      840

acaccctacg ttaccgtgct caagacggcg ggcgctaaca ccaccgacaa ggagctagag      900

gttctctcct tgcacaacgt cacctttgag gacgccgggg agtacacctg cctggcgggc      960

aattctattg ggttttctca tcactctgcg tggctggtgg tgctgccagc cgaggaggag     1020

ctggtggagg ctgacgaggc gggcagtgtg tatgcaggca tcctcagcta cgnggtgggc     1080

ttcttcctgt tcatcctggt ggtggcggct gtgacgctct gccgcctgcg cagccccccc     1140

aagaaaggcc tgggctcccc caccgtgcac aagatctccc gcttcccgct caagcgacag     1200

gtgtccctgg agtccaacgc gtccatgagc tccaacacac cactggtgcg catcgcaagg     1260

ctgtcctcag gggagggccc cacgctggcc aatgtctccg agctcgagct gcctgccgac     1320

cccaaatggg agctgtctcg ggcccggctg accctgggca agccccttgg ggagggctgc     1380

ttcggccagg tggtcatggc ggaggccatc ggcattgaca aggaccgggc cgccaagcct     1440

gtcaccgtag ccgtgaagat gctgaaagac gatgccactg acaaggacct gtcggacctg     1500

gtgtctgaga tggagatgat gaagatgatc gggaaacaca aaaacatcat caacctgctg     1560

ggcgcctgca cgcagggcgg gcccctgtac gtgctggtgg agtacgcggc caagggtaac     1620

ctgcgggagt ttctgcgggc gcggcggccc ccgggcctgg actactcctt cgacacctgc     1680

aagccgcccg aggagcagct caccttcaag gacctggtgt cctgtgccta ccaggtggcc     1740

cggggcatgg agtacttggc ctcccagaag tgcatccaca gggacctggc tgcccgcaat     1800

gtgctggtga ccgaggacaa cgtgatgaag atcgcagact tcgggctggc ccgggacgtg     1860

cacaacctcg actactacaa gaagacaacc aacggccggc tgcccgtgaa gtggatggcg     1920

cctgaggcct tgtttgaccg agtctacact caccagagtg acgtctggtc ctttggggtc     1980

ctgctctggg agatcttcac gctggggggc tccccgtacc ccggcatccc tgtggaggag     2040

ctcttcaagc tgctgaagga gggccaccgc atggacaagc ccgccaactg cacacacgac     2100

ctgtacatga tcatgcggga gtgctggcat gccgcgccct cccagaggcc caccttcaag     2160

cagctggtgg aggacctgga ccgtgtcctt accgtgacgt ccaccgacga gtacctggac     2220

ctgtcggcgc ctttcgagca gtactccccg ggtggccagg acacccccag ctccagctcc     2280

tcaggggacg actccgtgtt tgcccacgac ctgctgcccc cggccccacc cagcagtggg     2340

ggctcgcgga cgtga                                                      2355


<210>  21
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser 
            20          


<210>  22
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Ser Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
    290                 295                 300                 


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
305                 310                 315                 320 


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
                325                 330                 335     


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
            340                 345                 350         


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
        355                 360                 365             


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
    370                 375                 380                 


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
385                 390                 395                 400 


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
                405                 410                 415     


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
            420                 425                 430         


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
        435                 440                 445             


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
    450                 455                 460                 


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
465                 470                 475                 480 


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
                485                 490                 495     


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
            500                 505                 510         


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
        515                 520                 525             


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
    530                 535                 540                 


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
545                 550                 555                 560 


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
                565                 570                 575     


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
            580                 585                 590         


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
        595                 600                 605             


Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp 
    610                 615                 620                 


Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
625                 630                 635                 640 


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala 
                645                 650                 655     


His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
            660                 665                 670         


<210>  23
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Pro Leu Val 
            340                 345                 350         


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala Asn Val 
        355                 360                 365             


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Ala 
    370                 375                 380                 


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
385                 390                 395                 400 


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala Lys Pro 
                405                 410                 415     


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
            420                 425                 430         


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
        435                 440                 445             


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
    450                 455                 460                 


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
465                 470                 475                 480 


Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp Tyr Ser Phe Asp Thr Cys 
                485                 490                 495     


Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser Cys Ala 
            500                 505                 510         


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
        515                 520                 525             


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
    530                 535                 540                 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
545                 550                 555                 560 


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
                565                 570                 575     


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
            580                 585                 590         


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
        595                 600                 605             


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
    610                 615                 620                 


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
625                 630                 635                 640 


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
                645                 650                 655     


Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser Thr Asp 
            660                 665                 670         


Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
        675                 680                 685             


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Ala 
    690                 695                 700                 


His Asp Leu Leu Pro Pro Ala Pro Pro Ser Ser Gly Gly Ser Arg Thr 
705                 710                 715                 720 


<210>  24
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Ser Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Ser Gly Ser 
    290                 295                 300                 


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Val Val Phe Pro 
305                 310                 315                 320 


Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu Ala Gln 
                325                 330                 335     


Gln Ala Cys Leu Asp Gln Asp Ala Val Ile Ala Ser Phe Asp Gln Leu 
            340                 345                 350         


Tyr Asp Ala Trp Arg Gly Gly Leu Asp Trp Cys Asn Ala Gly Trp Leu 
        355                 360                 365             


Ser Asp Gly Ser Val Gln Tyr Pro Ile Thr Lys Pro Arg Glu Pro Cys 
    370                 375                 380                 


Gly Gly Gln Asn Thr Val Pro Gly Val Arg Asn Tyr Gly Phe Trp Asp 
385                 390                 395                 400 


Lys Asp Lys Ser Arg Tyr Asp Val Phe Cys Phe Thr Ser Asn Phe Asn 
                405                 410                 415     


Gly Arg Phe Tyr Tyr Leu Ile His Pro Thr Lys Leu Thr Tyr Asp Glu 
            420                 425                 430         


Ala Val Gln Ala Cys Leu Asn Asp Gly Ala Gln Ile Ala Lys Val Gly 
        435                 440                 445             


Gln Ile Phe Ala Ala Trp Lys Ile Leu Gly Tyr Asp Arg Cys Asp Ala 
    450                 455                 460                 


Gly Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Ser Arg Pro Arg 
465                 470                 475                 480 


Arg Arg Cys Ser Pro Thr Glu Ala Ala Val Arg Phe Val Gly Phe Pro 
                485                 490                 495     


Asp Lys Lys His Lys Leu Tyr Gly Val Tyr Cys Phe Arg Ala Tyr Asn 
            500                 505                 510         


<210>  25
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Glu Ser Leu Gly Thr Glu Gln Arg Val Val Gly Arg Ala Ala Glu Val 
1               5                   10                  15      


Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln Leu Val Phe Gly Ser Gly 
            20                  25                  30          


Asp Ala Val Glu Leu Ser Cys Pro Pro Pro Gly Gly Gly Pro Met Gly 
        35                  40                  45              


Pro Thr Val Trp Val Lys Asp Gly Thr Gly Leu Val Pro Ser Glu Arg 
    50                  55                  60                  


Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn Ala Ser His Glu 
65                  70                  75                  80  


Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg Leu Thr Gln Arg Val Leu 
                85                  90                  95      


Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser Ser Gly Asp Asp 
            100                 105                 110         


Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr Gly Val Asp Thr Gly Ala 
        115                 120                 125             


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
    130                 135                 140                 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
145                 150                 155                 160 


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Arg Glu Phe Arg Gly Glu 
                165                 170                 175     


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
            180                 185                 190         


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
        195                 200                 205             


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
    210                 215                 220                 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
225                 230                 235                 240 


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
                245                 250                 255     


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
            260                 265                 270         


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
        275                 280                 285             


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
    290                 295                 300                 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
305                 310                 315                 320 


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
                325                 330                 335     


Val Ser Leu Glu Ser Asn Ala Ser Met Ser Ser Asn Thr Ser Gly Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Val Val Phe Pro 
        355                 360                 365             


Tyr Phe Pro Arg Leu Gly Arg Tyr Asn Leu Asn Phe His Glu Ala Gln 
    370                 375                 380                 


Gln Ala Cys Leu Asp Gln Asp Ala Val Ile Ala Ser Phe Asp Gln Leu 
385                 390                 395                 400 


Tyr Asp Ala Trp Arg Gly Gly Leu Asp Trp Cys Asn Ala Gly Trp Leu 
                405                 410                 415     


Ser Asp Gly Ser Val Gln Tyr Pro Ile Thr Lys Pro Arg Glu Pro Cys 
            420                 425                 430         


Gly Gly Gln Asn Thr Val Pro Gly Val Arg Asn Tyr Gly Phe Trp Asp 
        435                 440                 445             


Lys Asp Lys Ser Arg Tyr Asp Val Phe Cys Phe Thr Ser Asn Phe Asn 
    450                 455                 460                 


Gly Arg Phe Tyr Tyr Leu Ile His Pro Thr Lys Leu Thr Tyr Asp Glu 
465                 470                 475                 480 


Ala Val Gln Ala Cys Leu Asn Asp Gly Ala Gln Ile Ala Lys Val Gly 
                485                 490                 495     


Gln Ile Phe Ala Ala Trp Lys Ile Leu Gly Tyr Asp Arg Cys Asp Ala 
            500                 505                 510         


Gly Trp Leu Ala Asp Gly Ser Val Arg Tyr Pro Ile Ser Arg Pro Arg 
        515                 520                 525             


Arg Arg Cys Ser Pro Thr Glu Ala Ala Val Arg Phe Val Gly Phe Pro 
    530                 535                 540                 


Asp Lys Lys His Lys Leu Tyr Gly Val Tyr Cys Phe Arg Ala Tyr Asn 
545                 550                 555                 560 


<210>  26
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  27
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  28
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210>  29
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Tyr Ser Ala Pro Ser Ala Cys Thr Cys Leu Cys Leu His Phe Leu 
1               5                   10                  15      


Leu Leu Cys Phe Gln Val Gln Val Leu Val Ala Glu Glu Asn Val Asp 
            20                  25                  30          


Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala Arg Asp Asp Val Ser 
        35                  40                  45              


Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys 
    50                  55                  60                  


His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala Arg Gly Glu Asp Gly 
65                  70                  75                  80  


Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp Thr Phe Gly Ser Gln 
                85                  90                  95      


Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr Leu Cys Met Asn Arg 
            100                 105                 110         


Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr Ser Lys Glu Cys Val 
        115                 120                 125             


Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr Ala Leu Met Ser Ala 
    130                 135                 140                 


Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys Lys Gly Arg Pro Arg 
145                 150                 155                 160 


Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp Val His Phe Met Lys 
                165                 170                 175     


Arg Tyr Pro Lys Gly Gln Pro Glu Leu Gln Lys Pro Phe Lys Tyr Thr 
            180                 185                 190         


Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro Thr His Pro Ala 
        195                 200                 205         


<210>  30
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  31
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  32
<211>  2019
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32
atggagtctc tgggcacaga gcagagagtc gtgggcagag ccgctgaagt gcctggacct       60

gagcctggcc agcaggaaca gctggtcttt ggctctggcg acgccgtgga actgagctgt      120

cctccacctg gcggaggccc tatgggacct accgtgtggg tcaaggatgg caccggactg      180

gtgcctagcg agagggtgct cgtgggacct cagagactgc aggtcctgaa cgccagccac      240

gaggatagcg gcgcctacag ctgcagacag agactgaccc agcgggtgct gtgccacttc      300

agcgtcagag tgaccgatgc ccccagcagc ggagatgacg aggatggcga ggatgaggcc      360

gaggatacag gcgtggacac aggcgcccct tactggacca gacccgagcg gatggacaag      420

aaactgctgg ccgtgcctgc cgccaacacc gtgcggttta gatgccctgc cgccggaaac      480

cccaccccca gcatctcttg gctgaagaac ggcagagagt tccggggcga gcaccggatc      540

ggcggcatta agctgagaca ccagcagtgg tccctggtca tggaaagcgt ggtgcccagc      600

gaccggggca actacacctg tgtggtggaa aacaagttcg gcagcatccg gcagacctac      660

accctggacg tgctggaaag aagcccccac agacctatcc tgcaggccgg actgcctgcc      720

aatcagacag ccgtgctggg cagcgacgtg gaatttcaca gcaaggtgta cagcgacgcc      780

cagccccaca tccagtggct gaagcacgtg gaagtgaacg gcagcaaagt gggccccgac      840

ggcacccctt acgtgaccgt gctgaaagtg tccctggaaa gcaacgccag catgagcagc      900

aacacccccc tcgtgcggat cgccagactg tctagcggag agggccctac cctggccaac      960

gtgtccgaac tggaactgcc cgccgacccc aagtgggagc tgagcagagc tagactgacc     1020

ctgggcaagc ctctgggcga gggctgtttt ggacaggtgg tcatggccga ggccatcggc     1080

atcgacaagg acagagccgc caagcctgtg accgtggccg tgaagatgct gaaggacgac     1140

gccaccgaca aggacctgag cgacctggtg tccgagatgg aaatgatgaa gatgatcggc     1200

aagcacaaga acatcatcaa cctgctgggc gcctgcaccc agggcggacc tctgtacgtg     1260

ctggtggaat acgccgccaa gggcaacctg agagagttcc tgagagccag aaggccccct     1320

ggcctggact acagcttcga tacctgcaag ccccccgaag aacagctgac cttcaaggat     1380

ctggtgtcct gcgcctatca ggtggccaga ggcatggaat acctggccag ccagaagtgc     1440

atccaccggg atctggccgc cagaaacgtg ctggtcaccg aggacaacgt gatgaagatc     1500

gccgacttcg gcctggcccg ggacgtgcac aacctggact actacaagaa aaccaccaac     1560

ggccggctgc ccgtgaagtg gatggcccct gaggccctgt tcgacagagt gtacacccac     1620

cagagcgacg tgtggtcctt cggcgtgctg ctgtgggaga tctttaccct gggcggcagc     1680

ccttaccccg gcatccctgt ggaagaactg ttcaagctgc tgaaagaggg ccacagaatg     1740

gacaagcccg ccaactgcac ccacgacctg tacatgatca tgagagagtg ctggcacgcc     1800

gctcccagcc agaggcctac ctttaagcag ctggtggaag atctggaccg ggtgctgacc     1860

gtgaccagca ccgacgagta cctggatctg agcgccccct tcgagcagta ctctcctggc     1920

ggccaggata cccctagcag cagctctagc ggcgacgaca gcgtgttcgc ccacgatctg     1980

ctgcctccag cccctcctag ctctggcggc tctagaacc                            2019


<210>  33
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33
atggagagcc tgggcacaga acagagagtc gtgggcagag ccgccgaagt gcctggacct       60

gaacctggcc agcaggaaca gctggtcttt ggctctggcg acgccgtgga actgagctgt      120

cctccacctg gcggaggccc tatgggacct accgtgtggg tcaaggatgg caccggactg      180

gtgcctagcg agagggtgct cgtgggacct cagagactgc aggtcctgaa cgccagccac      240

gaggatagcg gcgcctacag ctgcagacag agactgaccc agcgggtgct gtgccacttc      300

agcgtcagag tgaccgatgc ccccagcagc ggagatgacg aggatggcga ggatgaggcc      360

gaggatacag gcgtggacac aggcgcccct tactggacca gacccgagcg gatggacaag      420

aaactgctgg ccgtgcctgc cgccaacacc gtgcggttta gatgccctgc cgccggaaac      480

cccaccccca gcatctcttg gctgaagaac ggcagagagt tccggggcga gcaccggatc      540

ggcggcatta agctgagaca ccagcagtgg tccctggtca tggaaagcgt ggtgcccagc      600

gaccggggca actacacctg tgtggtggaa aacaagttcg gcagcatccg gcagacctac      660

accctggacg tgctggaaag aagcccccac agacctatcc tgcaggccgg actgcctgcc      720

aatcagacag ccgtgctggg cagcgacgtg gaatttcact gcaaggtgta cagcgacgcc      780

cagccccaca tccagtggct gaagcacgtg gaagtgaacg gcagcaaagt gggccccgac      840

ggcacccctt acgtgaccgt gctgaaagtg tccctggaaa gcaacgccag catgagcagc      900

aacaccagcg gcagcggctc tggcagcgga tctggttctg gctccggcag cgtggtgttc      960

ccctacttcc cccggctggg ccggtacaac ctgaactttc atgaggccca gcaggcctgc     1020

ctggaccagg atgccgtgat cgccagcttc gaccagctgt acgatgcttg gagaggcggc     1080

ctggactggt gcaatgccgg ctggctgtct gacggcagcg tgcagtaccc catcaccaag     1140

cccagagagc cctgcggcgg acagaatacc gtgcccggcg tgcggaacta cggcttctgg     1200

gacaaggaca agagcagata cgacgtgttc tgcttcacca gcaacttcaa cggccggttc     1260

tactacctga tccaccccac caagctgacc tacgacgagg ccgtgcaggc ctgtctgaac     1320

gatggcgccc agatcgccaa agtgggacag atcttcgccg cctggaagat cctgggctac     1380

gacagatgtg acgccggatg gctggccgac ggctccgtgc ggtatcccat cagccggcct     1440

agaagaagat gcagccctac cgaggccgcc gtcagattcg tgggcttccc c              1491


<210>  34
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34
atgggagcac cagcttgtgc cctggctctg tgtgtggccg tggctattgt ggctggcgcc       60

tctagcgaga gcctgggcac agaacagaga gtcgtgggca gagccgccga agtgcctgga      120

cctgaacctg gccagcagga acagctggtc tttggctctg gcgacgccgt ggaactgagc      180

tgtcctccac ctggcggagg ccctatggga cctaccgtgt gggtcaagga tggcaccgga      240

ctggtgccta gcgagagggt gctcgtggga cctcagagac tgcaggtcct gaacgccagc      300

cacgaggata gcggcgccta cagctgcaga cagagactga cccagcgggt gctgtgccac      360

ttcagcgtca gagtgaccga tgcccccagc agcggagatg acgaggatgg cgaggatgag      420

gccgaggata caggcgtgga cacaggcgcc ccttactgga ccagacccga gcggatggac      480

aagaaactgc tggccgtgcc tgccgccaac accgtgcggt ttagatgccc tgccgccgga      540

aaccccaccc ccagcatctc ttggctgaag aacggcagag agttccgggg cgagcaccgg      600

atcggcggca ttaagctgag acaccagcag tggtccctgg tcatggaaag cgtggtgccc      660

agcgaccggg gcaactacac ctgtgtggtg gaaaacaagt tcggcagcat ccggcagacc      720

tacaccctgg acgtgctgga aagaagcccc cacagaccta tcctgcaggc cggactgcct      780

gccaatcaga cagccgtgct gggcagcgac gtggaatttc actgcaaggt gtacagcgac      840

gcccagcccc acatccagtg gctgaagcac gtggaagtga acggcagcaa agtgggcccc      900

gacggcaccc cttacgtgac cgtgctgaaa accgctggcg ccaacaccac cgacaaagaa      960

ctggaagtgc tgagcctgca caacgtgacc ttcgaggacg ccggcgagta cacctgtctg     1020

gccggcaata gcatcggctt cagccaccac tctgcctggc tggtggtgct gccaggcgga     1080

ggctctgtgt ccctggaaag caacgccagc atgagcagca acaccagcgg cagcggctct     1140

ggcagcggat ctggttctgg ctccggcagc gtggtgttcc cctacttccc ccggctgggc     1200

cggtacaacc tgaactttca tgaggcccag caggcctgcc tggaccagga tgccgtgatc     1260

gccagcttcg accagctgta cgatgcttgg agaggcggcc tggactggtg caatgccggc     1320

tggctgtctg acggcagcgt gcagtacccc atcaccaagc ccagagagcc ctgcggcgga     1380

cagaataccg tgcccggcgt gcggaactac ggcttctggg acaaggacaa gagcagatac     1440

gacgtgttct gcttcaccag caacttcaac ggccggttct actacctgat ccaccccacc     1500

aagctgacct acgacgaggc cgtgcaggcc tgtctgaacg atggcgccca gatcgccaaa     1560

gtgggacaga tcttcgccgc ctggaagatc ctgggctacg acagatgtga cgccggatgg     1620

ctggccgacg gctccgtgcg gtatcccatc agccggccta gaagaagatg cagccctacc     1680

gaggccgccg tcagattcgt gggcttcccc                                      1710


<210>  35
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    50                  55                  60                  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235     


<210>  36
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    50                  55                  60                  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235     


<210>  37
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Gly Gly Gly Gly Ala Gly Gly Gly Gly 
1               5                   


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  40
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg 
65                  70                  75                  80  


Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu 
            100                 105                 110         


Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser 
        115                 120                 125             


Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys 
    130                 135                 140                 


Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly 
145                 150                 155                 160 


Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met 
                165                 170                 175     


Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr 
            180                 185                 190         


Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Val Val His Ser 
        195                 200                 205             


<210>  41
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  42
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  43
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe His Ala 
1               5                   10                  15      


Thr Gln Ala 
            


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
cagatgcact cccatcctcg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45
tctggggatg tccagtaggg                                                   20


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46
tggcagtgaa gatgttgaaa g                                                 21


<210>  47
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47
atcatcttca tcatctccat ctcttg                                            26


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48
ttatccttgg ctcctgggtg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49
ctggaaggta gcagtgggaa                                                   20


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50
gctcggaggt agaggtcttg t                                                 21


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51
ccacgctgac tggtaggaa                                                    19


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52
tttggtggac acaggcattg                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53
caaactgccc gatcatggag                                                   20


