                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
 
<120>  Production of retinol

<130>  32577-WO-PCT

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  325
<212>  PRT
<213>  Fusarium fujikuroi

<400>  1

Met Thr Thr Lys Tyr Thr Ser Val His Glu Ser Pro Asn Gly Pro Gly 
1               5                   10                  15      


Asp Ala Arg Pro Thr Ala Ser Gln Ile Ile Asp Asp Tyr Asn Leu Glu 
            20                  25                  30          


Gly Glu Leu Ser Gly Lys Thr Val Leu Val Thr Gly Cys Ser Ser Gly 
        35                  40                  45              


Ile Gly Val Glu Thr Ala Arg Ala Ile Tyr Arg Thr Gly Ala Thr Leu 
    50                  55                  60                  


Tyr Leu Thr Ala Arg Asp Val Asp Lys Ala Lys Thr Val Leu Pro Asp 
65                  70                  75                  80  


Leu Val Asp Thr Ser Arg Val His Phe Leu His Leu Asp Leu Asn Ser 
                85                  90                  95      


Leu Glu Ser Val Arg Gly Phe Ala Glu Asn Phe Lys Ser Lys Ser Thr 
            100                 105                 110         


Gln Leu His Ile Leu Ile Glu Asn Ala Gly Val Met Ala Cys Pro Glu 
        115                 120                 125             


Gly Arg Thr Val Asp Gly Phe Glu Thr Gln Phe Gly Ile Asn His Leu 
    130                 135                 140                 


Ala His Phe Leu Leu Phe Tyr Leu Leu Lys Asp Thr Leu Leu Asn Ser 
145                 150                 155                 160 


Ser Thr Pro Ala Phe Asn Ser Arg Val Val Ile Leu Ser Ser Cys Ala 
                165                 170                 175     


His Gln Ala Gly Ser Val His Leu Asn Asn Leu Ser Leu Glu Gly Gly 
            180                 185                 190         


Tyr Glu Pro Trp Lys Ser Tyr Gly Gln Ser Lys Thr Ala Asn Leu Trp 
        195                 200                 205             


Thr Ala Arg Glu Ile Glu Lys Arg Phe Gly Ala Ser Gly Ile His Ser 
    210                 215                 220                 


Trp Ala Val His Pro Gly Ser Ile Ala Thr Glu Leu Gln Arg His Val 
225                 230                 235                 240 


Ser Asp Glu Leu Lys Gln Lys Trp Ala Asp Asp Lys Glu Gly Ala Lys 
                245                 250                 255     


Leu Trp Lys Ser Thr Glu Gln Gly Ala Ala Thr Thr Val Leu Ala Ala 
            260                 265                 270         


Val Ser Pro Glu Leu Glu Gly Lys Gly Gly Leu Tyr Leu Glu Asp Thr 
        275                 280                 285             


Gln Val Ala Lys Pro Pro Ala Arg Gly Met Phe Gly Val Ala Asp Trp 
    290                 295                 300                 


Ala Tyr Asp Glu Asp Gly Pro Ser Lys Leu Trp Ala Lys Ser Leu Glu 
305                 310                 315                 320 


Leu Leu Lys Leu Gln 
                325 


<210>  2
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon-optimized

<400>  2
atgaccacta agtacacttc cgttcacgag tctcccaacg gccctggtga cgctcgaccc       60

accgcttccc agattatcga cgattacaac cttgagggag agctttctgg caagactgtt      120

ctcgtcaccg gctgttcctc tggtattggt gttgagactg cccgagctat ttaccgaact      180

ggtgccaccc tttacctcac tgcccgagat gtcgataagg ccaagaccgt tcttcccgac      240

cttgttgaca cttcccgagt ccactttctc caccttgacc ttaactctct ggagtctgtt      300

cgaggttttg ctgagaactt caagtctaag tccactcagc ttcacattct catcgagaac      360

gctggcgtga tggcctgtcc cgagggccga accgtcgatg gttttgagac tcagtttggt      420

atcaaccacc ttgctcactt tctcctcttt tacctcctca aggataccct tctcaactct      480

tctacccccg ctttcaactc ccgagttgtc atcctctctt cttgtgctca ccaggctggt      540

tccgttcacc ttaacaacct gtctcttgag ggtggatacg agccttggaa gtcttacggc      600

cagtccaaga ctgccaacct ttggactgcc cgagagatcg agaagcgatt tggtgcttcc      660

ggtatccact cttgggctgt tcaccccggt tccatcgcta ctgagcttca gcgacacgtt      720

tccgacgagc ttaagcagaa gtgggctgac gataaggagg gtgccaagct gtggaagtcc      780

accgagcagg gtgccgccac cactgtcctt gctgctgttt cccctgagct tgagggtaag      840

ggcggtcttt accttgagga tacccaggtt gccaagcccc ctgcccgagg aatgtttggt      900

gttgctgact gggcttacga tgaggatggc ccctctaagc tctgggccaa gtctcttgag      960

ctccttaagc tccagtaa                                                    978


<210>  3
<211>  620
<212>  PRT
<213>  Drosophila melanogaster

<400>  3

Met Ala Ala Gly Val Phe Lys Ser Phe Met Arg Asp Phe Phe Ala Val 
1               5                   10                  15      


Lys Tyr Asp Glu Gln Arg Asn Asp Pro Gln Ala Glu Arg Leu Asp Gly 
            20                  25                  30          


Asn Gly Arg Leu Tyr Pro Asn Cys Ser Ser Asp Val Trp Leu Arg Ser 
        35                  40                  45              


Cys Glu Arg Glu Ile Val Asp Pro Ile Glu Gly His His Ser Gly His 
    50                  55                  60                  


Ile Pro Lys Trp Ile Cys Gly Ser Leu Leu Arg Asn Gly Pro Gly Ser 
65                  70                  75                  80  


Trp Lys Val Gly Asp Met Thr Phe Gly His Leu Phe Asp Cys Ser Ala 
                85                  90                  95      


Leu Leu His Arg Phe Ala Ile Arg Asn Gly Arg Val Thr Tyr Gln Asn 
            100                 105                 110         


Arg Phe Val Asp Thr Glu Thr Leu Arg Lys Asn Arg Ser Ala Gln Arg 
        115                 120                 125             


Ile Val Val Thr Glu Phe Gly Thr Ala Ala Val Pro Asp Pro Cys His 
    130                 135                 140                 


Ser Ile Phe Asp Arg Phe Ala Ala Ile Phe Arg Pro Asp Ser Gly Thr 
145                 150                 155                 160 


Asp Asn Ser Met Ile Ser Ile Tyr Pro Phe Gly Asp Gln Tyr Tyr Thr 
                165                 170                 175     


Phe Thr Glu Thr Pro Phe Met His Arg Ile Asn Pro Cys Thr Leu Ala 
            180                 185                 190         


Thr Glu Ala Arg Ile Cys Thr Thr Asp Phe Val Gly Val Val Asn His 
        195                 200                 205             


Thr Ser His Pro His Val Leu Pro Ser Gly Thr Val Tyr Asn Leu Gly 
    210                 215                 220                 


Thr Thr Met Thr Arg Ser Gly Pro Ala Tyr Thr Ile Leu Ser Phe Pro 
225                 230                 235                 240 


His Gly Glu Gln Met Phe Glu Asp Ala His Val Val Ala Thr Leu Pro 
                245                 250                 255     


Cys Arg Trp Lys Leu His Pro Gly Tyr Met His Thr Phe Gly Leu Thr 
            260                 265                 270         


Asp His Tyr Phe Val Ile Val Glu Gln Pro Leu Ser Val Ser Leu Thr 
        275                 280                 285             


Glu Tyr Ile Lys Ala Gln Leu Gly Gly Gln Asn Leu Ser Ala Cys Leu 
    290                 295                 300                 


Lys Trp Phe Glu Asp Arg Pro Thr Leu Phe His Leu Ile Asp Arg Val 
305                 310                 315                 320 


Ser Gly Lys Leu Val Gln Thr Tyr Glu Ser Glu Ala Phe Phe Tyr Leu 
                325                 330                 335     


His Ile Ile Asn Cys Phe Glu Arg Asp Gly His Val Val Val Asp Ile 
            340                 345                 350         


Cys Ser Tyr Arg Asn Pro Glu Met Ile Asn Cys Met Tyr Leu Glu Ala 
        355                 360                 365             


Ile Ala Asn Met Gln Thr Asn Pro Asn Tyr Ala Thr Leu Phe Arg Gly 
    370                 375                 380                 


Arg Pro Leu Arg Phe Val Leu Pro Leu Gly Thr Ile Pro Pro Ala Ser 
385                 390                 395                 400 


Ile Ala Lys Arg Gly Leu Val Lys Ser Phe Ser Leu Ala Gly Leu Ser 
                405                 410                 415     


Ala Pro Gln Val Ser Arg Thr Met Lys His Ser Val Ser Gln Tyr Ala 
            420                 425                 430         


Asp Ile Thr Tyr Met Pro Thr Asn Gly Lys Gln Ala Thr Ala Gly Glu 
        435                 440                 445             


Glu Ser Pro Lys Arg Asp Ala Lys Arg Gly Arg Tyr Glu Glu Glu Asn 
    450                 455                 460                 


Leu Val Asn Leu Val Thr Met Glu Gly Ser Gln Ala Glu Ala Phe Gln 
465                 470                 475                 480 


Gly Thr Asn Gly Ile Gln Leu Arg Pro Glu Met Leu Cys Asp Trp Gly 
                485                 490                 495     


Cys Glu Thr Pro Arg Ile Tyr Tyr Glu Arg Tyr Met Gly Lys Asn Tyr 
            500                 505                 510         


Arg Tyr Phe Tyr Ala Ile Ser Ser Asp Val Asp Ala Val Asn Pro Gly 
        515                 520                 525             


Thr Leu Ile Lys Val Asp Val Trp Asn Lys Ser Cys Leu Thr Trp Cys 
    530                 535                 540                 


Glu Glu Asn Val Tyr Pro Ser Glu Pro Ile Phe Val Pro Ser Pro Asp 
545                 550                 555                 560 


Pro Lys Ser Glu Asp Asp Gly Val Ile Leu Ala Ser Met Val Leu Gly 
                565                 570                 575     


Gly Leu Asn Asp Arg Tyr Val Gly Leu Ile Val Leu Cys Ala Lys Thr 
            580                 585                 590         


Met Thr Glu Leu Gly Arg Cys Asp Phe His Thr Asn Gly Pro Val Pro 
        595                 600                 605             


Lys Cys Leu His Gly Trp Phe Ala Pro Asn Ala Ile 
    610                 615                 620 


<210>  4
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon-optimized

<400>  4
atggccgctg gtgttttcaa gtcttttatg cgagatttct ttgctgttaa gtacgatgag       60

cagcgaaacg acccccaggc cgagcgactg gacggcaacg gacgactgta ccccaactgc      120

tcctctgatg tttggcttcg atcttgcgag cgagagatcg ttgaccccat tgagggccac      180

cactccggtc acattcccaa gtggatttgc ggttccctgc tccgaaacgg ccccggctct      240

tggaaggttg gcgacatgac cttcggccac ctgttcgact gctccgccct gctccaccga      300

tttgccattc gaaacggacg agtcacctac cagaaccgat ttgttgacac tgagactctg      360

cgaaagaacc gatctgccca gcgaattgtt gtcaccgagt ttggcactgc cgctgttccc      420

gatccctgtc actccatctt cgaccgattt gccgccattt ttcgacccga ttctggaacc      480

gataactcca tgatttccat ctaccccttc ggcgaccagt actacacttt caccgagact      540

ccctttatgc accgaattaa cccctgcact ctcgctactg aggctcgaat ctgcaccacc      600

gacttcgttg gcgttgtcaa ccacacttct cacccccacg ttcttccctc tggcactgtt      660

tacaacctgg gcaccactat gacccgatct ggacccgctt acactatcct ctctttcccc      720

cacggcgagc agatgttcga ggacgctcac gttgtcgcca ctctgccctg ccgatggaag      780

ctgcaccccg gttatatgca caccttcggc ctcactgacc actactttgt cattgttgag      840

cagccccttt ccgtttccct cactgagtac atcaaggccc agcttggcgg acagaacctt      900

tccgcttgcc tcaagtggtt cgaggaccga cccactctct ttcaccttat tgatcgagtt      960

tccggcaagc tggtccagac ctacgagtcc gaggctttct tctacctgca catcatcaac     1020

tgctttgagc gagatggcca cgttgtcgtt gacatttgct cttaccgaaa ccccgagatg     1080

attaactgca tgtacctgga ggccattgcc aacatgcaga ctaaccccaa ctacgctacc     1140

ctctttcgag gacgacccct tcgattcgtc ctgcccctcg gcactattcc ccccgcctct     1200

atcgccaagc gaggactcgt caagtccttc tccctcgctg gactctccgc tccccaggtt     1260

tctcgaacca tgaagcactc cgtttctcag tacgccgata ttacctacat gcccaccaac     1320

ggaaagcagg ccactgctgg agaggagtcc cccaagcgag atgccaagcg aggccgatac     1380

gaggaggaga accttgtcaa cctggttact atggagggct ctcaggccga ggcttttcag     1440

ggcaccaacg gcattcagct tcgacccgag atgctgtgtg attggggctg tgagactccc     1500

cgaatctact acgagcgata catgggcaag aactaccgat acttctacgc catttcttcc     1560

gatgttgatg ctgtcaaccc cggcaccctc atcaaggttg atgtctggaa caagtcttgt     1620

cttacctggt gcgaggagaa cgtctacccc tctgagccca tttttgtccc ctctcccgat     1680

cccaagtccg aggacgatgg cgttatcctg gcctctatgg ttcttggcgg tcttaacgac     1740

cgatacgtcg gccttattgt tctttgtgcc aagaccatga ccgagctggg ccgatgtgat     1800

ttccacacca acggacccgt tcccaagtgc ctccacggtt ggtttgctcc caacgccatt     1860

tag                                                                   1863


<210>  5
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon-optimized

<400>  5
atggctccct ccattcgaaa gttctttgct ggtggtgtgt gtcgaactaa cgttcagctt       60

cccggtaagg tggttgtcat cactggtgcc aacaccggca ttggcaagga gactgcccga      120

gagctcgctt cccgaggagc ccgagtttac attgcttgcc gagatgttct gaagggcgag      180

tctgctgcct ctgagattcg agttgacact aagaactccc aggtgctcgt gcgaaagctc      240

gacctttccg acactaagtc tatccgagcc tttgctgagg gctttctcgc tgaggagaag      300

cagcttcaca ttctgattaa caacgctgga gttatgatgt gtccttactc taagactgct      360

gatggtttcg agactcacct cggagtcaac cacctgggcc acttcctcct cacctacctg      420

ctcctggagc gactcaaggt gtctgcccct gcccgagtgg ttaacgtttc ctccgtggct      480

caccacattg gcaagattcc cttccacgac ctccagtccg agaagcgata ctcccgaggt      540

tttgcttact gccactccaa gctggccaac gttctcttta cccgagagct ggccaagcga      600

ctccagggaa ccggcgtcac cacctacgcc gttcaccccg gtgtcgtccg atccgagctg      660

gtccgacact cctccctgct ctgcctgctc tggcgactct tctccccctt cgttaagacc      720

gcccgagagg gtgcccagac ctccctgcac tgcgccctgg ctgagggcct ggagcccctg      780

tctggcaagt acttctctga ctgcaagcga acctgggtgt ctccccgagc tcgaaacaac      840

aagactgccg agcgactctg gaacgtttcc tgtgagcttc tcggtattcg atgggagtag      900


<210>  6
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon-optimized

<400>  6
atgactccct ccattcgaaa gttctttgct ggtggagttt gtactaccaa ggtccagatc       60

cccggaaagg ttgtggtcat cactggtgcc aacactggca ttggcaagga gactgcccga      120

gagcttgctc gacgaggagc ccgagtttac attgcctgtc gagatgtcct gaagggagag      180

tctgctgcct ctgagattcg agccgatacc aagaactccc aggttctcgt gcgaaagctg      240

gacctctctg acaccaagtc tatccgaacc tttgctgagg gcttccttgc tgaggagaag      300

aagctgcaca ttcttattaa caacgctggc gtgatgatgt gtccttactc taagactgtc      360

gatggttttg agactcactt tggtgtcaac cacctgggcc acttccttct cacttacctt      420

ctccttggcc gactgaagga gtctgctccc gcccgagtga ttaacctctc ttccgtggct      480

caccttggtg gcaagatccg atttcacgac cttcagtcca agaagcgata ctgctctggt      540

ttcgcttact ctcactccaa gctggccaac gtccttttca cccgagagct ggccaagcga      600

ctccagggaa ccggagtcac cgcttacgtg gttcaccctg gttgcgtcct gtctgagatc      660

acccgacact ccttcctgat gtgccttctc tggcgactct tctccccctt cttcaagtcc      720

ccttggcagg gagcccagac ctccctgcac tgcgccctgg aggagggcct ggagcccctg      780

tccggaaagt acttctctga ctgcaagcga acctgggttt ctccccgagc tcgaaacaag      840

aagactgccg agcgactgtg gaacgtttcc tgtgagcttc tcggaatcca gtgggagtaa      900


<210>  7
<211>  1887
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon-optimized

<400>  7
atgctcactc ccgccgctga gaaccccctt cgagagcagg gactccctgc cccctctccc       60

accggataca acaacgttcc cgctttcaac aagcctgttg agcttaccat tgagggcact      120

attcctgagt gggttaacgg tgtcatgtac cgagctggtt ctggccgata caaccttctc      180

cttgagaacg gcgatacctt ccacatcgga caccctttcg atggtctggc tatgcttcac      240

cgatttgagc tttctggtga gactcagact gttcagtact cctcccgaca cacctcccac      300

ggagttgagc gacgaatccg agagaaggac cctacccttc tcacctttgg tcctgacccc      360

tgtaagacca tttttggccg aatccagtcc gtttaccacc acatctccaa gttcggcgct      420

aacgctcaga ttcaggaggg cgaccccgag ttcgatatgg ttaacgttac cattacccct      480

aacttccccc ttggtgagcg actggaggcc gagactggtg ttaagcgagg cgatgctctt      540

gttgtcaagc gagatgctaa cacccttcag ctcgttgata acaagaccct taagcctatc      600

aagatgttca cttacggtca cgttaacgat aagctccagg gtcagctttg cgcttctcac      660

caccagtacg atgaggagac tgacgagtac gttaacttca ccgttcgact cggtcctatt      720

ccctcttttc agtcttacac ccttggtcct taccttccca ctccccctgg ctctaaggag      780

aagatgcctg cccctcaggt tcgacttcac gagcctattt accgacacct tggtgcctgg      840

cgaacccttg agcctctcaa gcctgcttac attcactcct tctccatgac taagaactac      900

attatcgttc ctaacttccc ttactactac tctttcggag gcatgtccgc cctttactac      960

tcttgtgctt accagacttt ctactgggat gagactcgac ccactctctt tcacgttgtt     1020

gaccgaaaca ctggccgaca cgttgctact tacgatgctg acccttgctt ttctttccac     1080

tctgctaacg cttgggatga ggaggtcgat ctccctggtg gtggtaagga gcgagtgatt     1140

tacatggact actgtgttta cgagaacact gacattgtcg atgcttcttt cgatctcggt     1200

aagactccca ctggttttga cgcttccaag gtcgagcctg ctcgattcaa gatcaagcga     1260

cacaccgatg acaagaagga taactccatt tctccttccc agcttcgacg ataccgactt     1320

ggtaacgttc ctgtctcctc taacgctcct gagacttccc gatggtcccc taagggaatt     1380

accggcctcc tttccggcat ttttgacttt aacaagcgac gagtggcttc ttacactgtt     1440

cttggctccg atattgagct tccccgattc aactctaact tcaacctgcg aaagtaccga     1500

tacgtgtggg gtgtttgtga gtctaagcac gctccttctt acgcttctgg tgccgttgtt     1560

aacggtctta ttaagctcga tctcgataag cctacccttt gcaagaacac tgaggagggt     1620

tcctctgcta agatttggga tgagcccggc tgttcttgtt ccgagcccat ttttgtcgcc     1680

caccctgagc agcgagctga ggatgacggt gttcttattt ctactgtcaa cactaccacc     1740

cctgacggaa aggagtcttg ctttctcctt atcgttgatg ctgctactat ggttgaggtt     1800

ggccgaacca ctctcggtgc tttcactgcc atgactatcc acggctcttt tgtcgatacc     1860

aacggaaagg gtgttgctgt taactaa                                         1887


