                         SEQUENCE LISTING

<110>  LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
 
<120>  ACETATE TOXICITY TOLERANCE IN RECOMBINANT MICROBIAL HOST 
       CELLS

<130>  55729550-23PCT

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  910
<212>  PRT
<213>  Bifidobacterium adolescentis

<400>  1

Met Ala Asp Ala Lys Lys Lys Glu Glu Pro Thr Lys Pro Thr Pro Glu 
1               5                   10                  15      


Glu Lys Leu Ala Ala Ala Glu Ala Glu Val Asp Ala Leu Val Lys Lys 
            20                  25                  30          


Gly Leu Lys Ala Leu Asp Glu Phe Glu Lys Leu Asp Gln Lys Gln Val 
        35                  40                  45              


Asp His Ile Val Ala Lys Ala Ser Val Ala Ala Leu Asn Lys His Leu 
    50                  55                  60                  


Val Leu Ala Lys Met Ala Val Glu Glu Thr His Arg Gly Leu Val Glu 
65                  70                  75                  80  


Asp Lys Ala Thr Lys Asn Ile Phe Ala Cys Glu His Val Thr Asn Tyr 
                85                  90                  95      


Leu Ala Gly Gln Lys Thr Val Gly Ile Ile Arg Glu Asp Asp Val Leu 
            100                 105                 110         


Gly Ile Asp Glu Ile Ala Glu Pro Val Gly Val Val Ala Gly Val Thr 
        115                 120                 125             


Pro Val Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ala 
    130                 135                 140                 


Leu Lys Thr Arg Cys Pro Ile Ile Phe Gly Phe His Pro Gly Ala Gln 
145                 150                 155                 160 


Asn Cys Ser Val Ala Ala Ala Lys Ile Val Arg Asp Ala Ala Ile Ala 
                165                 170                 175     


Ala Gly Ala Pro Glu Asn Cys Ile Gln Trp Ile Glu His Pro Ser Ile 
            180                 185                 190         


Glu Ala Thr Gly Ala Leu Met Lys His Asp Gly Val Ala Thr Ile Leu 
        195                 200                 205             


Ala Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys 
    210                 215                 220                 


Pro Ala Leu Gly Val Gly Ala Gly Asn Ala Pro Ala Tyr Val Asp Lys 
225                 230                 235                 240 


Asn Val Asp Val Val Arg Ala Ala Asn Asp Leu Ile Leu Ser Lys His 
                245                 250                 255     


Phe Asp Tyr Gly Met Ile Cys Ala Thr Glu Gln Ala Ile Ile Ala Asp 
            260                 265                 270         


Lys Asp Ile Tyr Ala Pro Leu Val Lys Glu Leu Lys Arg Arg Lys Ala 
        275                 280                 285             


Tyr Phe Val Asn Ala Asp Glu Lys Ala Lys Leu Glu Gln Tyr Met Phe 
    290                 295                 300                 


Gly Cys Thr Ala Tyr Ser Gly Gln Thr Pro Lys Leu Asn Ser Val Val 
305                 310                 315                 320 


Pro Gly Lys Ser Pro Gln Tyr Ile Ala Lys Ala Ala Gly Phe Glu Ile 
                325                 330                 335     


Pro Glu Asp Ala Thr Ile Leu Ala Ala Glu Cys Lys Glu Val Gly Glu 
            340                 345                 350         


Asn Glu Pro Leu Thr Met Glu Lys Leu Ala Pro Val Gln Ala Val Leu 
        355                 360                 365             


Lys Ser Asp Asn Lys Glu Gln Ala Phe Glu Met Cys Glu Ala Met Leu 
    370                 375                 380                 


Lys His Gly Ala Gly His Thr Ala Ala Ile His Thr Asn Asp Arg Asp 
385                 390                 395                 400 


Leu Val Arg Glu Tyr Gly Gln Arg Met His Ala Cys Arg Ile Ile Trp 
                405                 410                 415     


Asn Ser Pro Ser Ser Leu Gly Gly Val Gly Asp Ile Tyr Asn Ala Ile 
            420                 425                 430         


Ala Pro Ser Leu Thr Leu Gly Cys Gly Ser Tyr Gly Gly Asn Ser Val 
        435                 440                 445             


Ser Gly Asn Val Gln Ala Val Asn Leu Ile Asn Ile Lys Arg Ile Ala 
    450                 455                 460                 


Arg Arg Asn Asn Asn Met Gln Trp Phe Lys Ile Pro Ala Lys Thr Tyr 
465                 470                 475                 480 


Phe Glu Pro Asn Ala Ile Lys Tyr Leu Arg Asp Met Tyr Gly Ile Glu 
                485                 490                 495     


Lys Ala Val Ile Val Cys Asp Lys Val Met Glu Gln Leu Gly Ile Val 
            500                 505                 510         


Asp Lys Ile Ile Asp Gln Leu Arg Ala Arg Ser Asn Arg Val Thr Phe 
        515                 520                 525             


Arg Ile Ile Asp Tyr Val Glu Pro Glu Pro Ser Val Glu Thr Val Glu 
    530                 535                 540                 


Arg Gly Ala Ala Met Met Arg Glu Glu Phe Glu Pro Asp Thr Ile Ile 
545                 550                 555                 560 


Ala Val Gly Gly Gly Ser Pro Met Asp Ala Ser Lys Ile Met Trp Leu 
                565                 570                 575     


Leu Tyr Glu His Pro Glu Ile Ser Phe Ser Asp Val Arg Glu Lys Phe 
            580                 585                 590         


Phe Asp Ile Arg Lys Arg Ala Phe Lys Ile Pro Pro Leu Gly Lys Lys 
        595                 600                 605             


Ala Lys Leu Val Cys Ile Pro Thr Ser Ser Gly Thr Gly Ser Glu Val 
    610                 615                 620                 


Thr Pro Phe Ala Val Ile Thr Asp His Lys Thr Gly Tyr Lys Tyr Pro 
625                 630                 635                 640 


Ile Thr Asp Tyr Ala Leu Thr Pro Ser Val Ala Ile Val Asp Pro Val 
                645                 650                 655     


Leu Ala Arg Thr Gln Pro Arg Lys Leu Ala Ser Asp Ala Gly Phe Asp 
            660                 665                 670         


Ala Leu Thr His Ala Phe Glu Ala Tyr Val Ser Val Tyr Ala Asn Asp 
        675                 680                 685             


Phe Thr Asp Gly Met Ala Leu His Ala Ala Lys Leu Val Trp Asp Asn 
    690                 695                 700                 


Leu Ala Glu Ser Val Asn Gly Glu Pro Gly Glu Glu Lys Thr Arg Ala 
705                 710                 715                 720 


Gln Glu Lys Met His Asn Ala Ala Thr Met Ala Gly Met Ala Phe Gly 
                725                 730                 735     


Ser Ala Phe Leu Gly Met Cys His Gly Met Ala His Thr Ile Gly Ala 
            740                 745                 750         


Leu Cys His Val Ala His Gly Arg Thr Asn Ser Ile Leu Leu Pro Tyr 
        755                 760                 765             


Val Ile Arg Tyr Asn Gly Ser Val Pro Glu Glu Pro Thr Ser Trp Pro 
    770                 775                 780                 


Lys Tyr Asn Lys Tyr Ile Ala Pro Glu Arg Tyr Gln Glu Ile Ala Lys 
785                 790                 795                 800 


Asn Leu Gly Val Asn Pro Gly Lys Thr Pro Glu Glu Gly Val Glu Asn 
                805                 810                 815     


Leu Ala Lys Ala Val Glu Asp Tyr Arg Asp Asn Lys Leu Gly Met Asn 
            820                 825                 830         


Lys Ser Phe Gln Glu Cys Gly Val Asp Glu Asp Tyr Tyr Trp Ser Ile 
        835                 840                 845             


Ile Asp Gln Ile Gly Met Arg Ala Tyr Glu Asp Gln Cys Ala Pro Ala 
    850                 855                 860                 


Asn Pro Arg Ile Pro Gln Ile Glu Asp Met Lys Asp Ile Ala Ile Ala 
865                 870                 875                 880 


Ala Tyr Tyr Gly Val Ser Gln Ala Glu Gly His Lys Leu Arg Val Gln 
                885                 890                 895     


Arg Gln Gly Glu Ala Ala Thr Glu Glu Ala Ser Glu Arg Ala 
            900                 905                 910 


<210>  2
<211>  569
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Lys Asp Leu Lys Leu Ser Asn Phe Lys Gly Lys Phe Ile Ser Arg 
1               5                   10                  15      


Thr Ser His Trp Gly Leu Thr Gly Lys Lys Leu Arg Tyr Phe Ile Thr 
            20                  25                  30          


Ile Ala Ser Met Thr Gly Phe Ser Leu Phe Gly Tyr Asp Gln Gly Leu 
        35                  40                  45              


Met Ala Ser Leu Ile Thr Gly Lys Gln Phe Asn Tyr Glu Phe Pro Ala 
    50                  55                  60                  


Thr Lys Glu Asn Gly Asp His Asp Arg His Ala Thr Val Val Gln Gly 
65                  70                  75                  80  


Ala Thr Thr Ser Cys Tyr Glu Leu Gly Cys Phe Ala Gly Ser Leu Phe 
                85                  90                  95      


Val Met Phe Cys Gly Glu Arg Ile Gly Arg Lys Pro Leu Ile Leu Met 
            100                 105                 110         


Gly Ser Val Ile Thr Ile Ile Gly Ala Val Ile Ser Thr Cys Ala Phe 
        115                 120                 125             


Arg Gly Tyr Trp Ala Leu Gly Gln Phe Ile Ile Gly Arg Val Val Thr 
    130                 135                 140                 


Gly Val Gly Thr Gly Leu Asn Thr Ser Thr Ile Pro Val Trp Gln Ser 
145                 150                 155                 160 


Glu Met Ser Lys Ala Glu Asn Arg Gly Leu Leu Val Asn Leu Glu Gly 
                165                 170                 175     


Ser Thr Ile Ala Phe Gly Thr Met Ile Ala Tyr Trp Ile Asp Phe Gly 
            180                 185                 190         


Leu Ser Tyr Thr Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ser Met 
        195                 200                 205             


Gln Ile Val Phe Ala Leu Phe Leu Leu Ala Phe Met Ile Lys Leu Pro 
    210                 215                 220                 


Glu Ser Pro Arg Trp Leu Ile Ser Gln Ser Arg Thr Glu Glu Ala Arg 
225                 230                 235                 240 


Tyr Leu Val Gly Thr Leu Asp Asp Ala Asp Pro Asn Asp Glu Glu Val 
                245                 250                 255     


Ile Thr Glu Val Ala Met Leu His Asp Ala Val Asn Arg Thr Lys His 
            260                 265                 270         


Glu Lys His Ser Leu Ser Ser Leu Phe Ser Arg Gly Arg Ser Gln Asn 
        275                 280                 285             


Leu Gln Arg Ala Leu Ile Ala Ala Ser Thr Gln Phe Phe Gln Gln Phe 
    290                 295                 300                 


Thr Gly Cys Asn Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Asn Lys 
305                 310                 315                 320 


Thr Ile Lys Leu Asp Tyr Arg Leu Ser Met Ile Ile Gly Gly Val Phe 
                325                 330                 335     


Ala Thr Ile Tyr Ala Leu Ser Thr Ile Gly Ser Phe Phe Leu Ile Glu 
            340                 345                 350         


Lys Leu Gly Arg Arg Lys Leu Phe Leu Leu Gly Ala Thr Gly Gln Ala 
        355                 360                 365             


Val Ser Phe Thr Ile Thr Phe Ala Cys Leu Val Lys Glu Asn Lys Glu 
    370                 375                 380                 


Asn Ala Arg Gly Ala Ala Val Gly Leu Phe Leu Phe Ile Thr Phe Phe 
385                 390                 395                 400 


Gly Leu Ser Leu Leu Ser Leu Pro Trp Ile Tyr Pro Pro Glu Ile Ala 
                405                 410                 415     


Ser Met Lys Val Arg Ala Ser Thr Asn Ala Phe Ser Thr Cys Thr Asn 
            420                 425                 430         


Trp Leu Cys Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Gly 
        435                 440                 445             


Gln Ser Gly Trp Gly Cys Tyr Leu Phe Phe Ala Val Met Asn Tyr Leu 
    450                 455                 460                 


Tyr Ile Pro Val Ile Phe Phe Phe Tyr Pro Glu Thr Ala Gly Arg Ser 
465                 470                 475                 480 


Leu Glu Glu Ile Asp Ile Ile Phe Ala Lys Ala Tyr Glu Asp Gly Thr 
                485                 490                 495     


Gln Pro Trp Arg Val Ala Asn His Leu Pro Lys Leu Ser Leu Gln Glu 
            500                 505                 510         


Val Glu Asp His Ala Asn Ala Leu Gly Ser Tyr Asp Asp Glu Met Glu 
        515                 520                 525             


Lys Glu Asp Phe Gly Glu Asp Arg Val Glu Asp Thr Tyr Asn Gln Ile 
    530                 535                 540                 


Asn Gly Asp Asn Ser Ser Ser Ser Ser Asn Ile Lys Asn Glu Asp Thr 
545                 550                 555                 560 


Val Asn Asp Lys Ala Asn Phe Glu Gly 
                565                 


<210>  3
<211>  683
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Thr Ile Lys Glu His Lys Val Val Tyr Glu Ala His Asn Val Lys 
1               5                   10                  15      


Ala Leu Lys Ala Pro Gln His Phe Tyr Asn Ser Gln Pro Gly Lys Gly 
            20                  25                  30          


Tyr Val Thr Asp Met Gln His Tyr Gln Glu Met Tyr Gln Gln Ser Ile 
        35                  40                  45              


Asn Glu Pro Glu Lys Phe Phe Asp Lys Met Ala Lys Glu Tyr Leu His 
    50                  55                  60                  


Trp Asp Ala Pro Tyr Thr Lys Val Gln Ser Gly Ser Leu Asn Asn Gly 
65                  70                  75                  80  


Asp Val Ala Trp Phe Leu Asn Gly Lys Leu Asn Ala Ser Tyr Asn Cys 
                85                  90                  95      


Val Asp Arg His Ala Phe Ala Asn Pro Asp Lys Pro Ala Leu Ile Tyr 
            100                 105                 110         


Glu Ala Asp Asp Glu Ser Asp Asn Lys Ile Ile Thr Phe Gly Glu Leu 
        115                 120                 125             


Leu Arg Lys Val Ser Gln Ile Ala Gly Val Leu Lys Ser Trp Gly Val 
    130                 135                 140                 


Lys Lys Gly Asp Thr Val Ala Ile Tyr Leu Pro Met Ile Pro Glu Ala 
145                 150                 155                 160 


Val Ile Ala Met Leu Ala Val Ala Arg Ile Gly Ala Ile His Ser Val 
                165                 170                 175     


Val Phe Ala Gly Phe Ser Ala Gly Ser Leu Lys Asp Arg Val Val Asp 
            180                 185                 190         


Ala Asn Ser Lys Val Val Ile Thr Cys Asp Glu Gly Lys Arg Gly Gly 
        195                 200                 205             


Lys Thr Ile Asn Thr Lys Lys Ile Val Asp Glu Gly Leu Asn Gly Val 
    210                 215                 220                 


Asp Leu Val Ser Arg Ile Leu Val Phe Gln Arg Thr Gly Thr Glu Gly 
225                 230                 235                 240 


Ile Pro Met Lys Ala Gly Arg Asp Tyr Trp Trp His Glu Glu Ala Ala 
                245                 250                 255     


Lys Gln Arg Thr Tyr Leu Pro Pro Val Ser Cys Asp Ala Glu Asp Pro 
            260                 265                 270         


Leu Phe Leu Leu Tyr Thr Ser Gly Ser Thr Gly Ser Pro Lys Gly Val 
        275                 280                 285             


Val His Thr Thr Gly Gly Tyr Leu Leu Gly Ala Ala Leu Thr Thr Arg 
    290                 295                 300                 


Tyr Val Phe Asp Ile His Pro Glu Asp Val Leu Phe Thr Ala Gly Asp 
305                 310                 315                 320 


Val Gly Trp Ile Thr Gly His Thr Tyr Ala Leu Tyr Gly Pro Leu Thr 
                325                 330                 335     


Leu Gly Thr Ala Ser Ile Ile Phe Glu Ser Thr Pro Ala Tyr Pro Asp 
            340                 345                 350         


Tyr Gly Arg Tyr Trp Arg Ile Ile Gln Arg His Lys Ala Thr His Phe 
        355                 360                 365             


Tyr Val Ala Pro Thr Ala Leu Arg Leu Ile Lys Arg Val Gly Glu Ala 
    370                 375                 380                 


Glu Ile Ala Lys Tyr Asp Thr Ser Ser Leu Arg Val Leu Gly Ser Val 
385                 390                 395                 400 


Gly Glu Pro Ile Ser Pro Asp Leu Trp Glu Trp Tyr His Glu Lys Val 
                405                 410                 415     


Gly Asn Lys Asn Cys Val Ile Cys Asp Thr Met Trp Gln Thr Glu Ser 
            420                 425                 430         


Gly Ser His Leu Ile Ala Pro Leu Ala Gly Ala Val Pro Thr Lys Pro 
        435                 440                 445             


Gly Ser Ala Thr Val Pro Phe Phe Gly Ile Asn Ala Cys Ile Ile Asp 
    450                 455                 460                 


Pro Val Thr Gly Val Glu Leu Glu Gly Asn Asp Val Glu Gly Val Leu 
465                 470                 475                 480 


Ala Val Lys Ser Pro Trp Pro Ser Met Ala Arg Ser Val Trp Asn His 
                485                 490                 495     


His Asp Arg Tyr Met Asp Thr Tyr Leu Lys Pro Tyr Pro Gly His Tyr 
            500                 505                 510         


Phe Thr Gly Asp Gly Ala Gly Arg Asp His Asp Gly Tyr Tyr Trp Ile 
        515                 520                 525             


Arg Gly Arg Val Asp Asp Val Val Asn Val Ser Gly His Arg Leu Ser 
    530                 535                 540                 


Thr Ser Glu Ile Glu Ala Ser Ile Ser Asn His Glu Asn Val Ser Glu 
545                 550                 555                 560 


Ala Ala Val Val Gly Ile Pro Asp Glu Leu Thr Gly Gln Thr Val Val 
                565                 570                 575     


Ala Tyr Val Ser Leu Lys Asp Gly Tyr Leu Gln Asn Asn Ala Thr Glu 
            580                 585                 590         


Gly Asp Ala Glu His Ile Thr Pro Asp Asn Leu Arg Arg Glu Leu Ile 
        595                 600                 605             


Leu Gln Val Arg Gly Glu Ile Gly Pro Phe Ala Ser Pro Lys Thr Ile 
    610                 615                 620                 


Ile Leu Val Arg Asp Leu Pro Arg Thr Arg Ser Gly Lys Ile Met Arg 
625                 630                 635                 640 


Arg Val Leu Arg Lys Val Ala Ser Asn Glu Ala Glu Gln Leu Gly Asp 
                645                 650                 655     


Leu Thr Thr Leu Ala Asn Pro Glu Val Val Pro Ala Ile Ile Ser Ala 
            660                 665                 670         


Val Glu Asn Gln Phe Phe Ser Gln Lys Lys Lys 
        675                 680             


<210>  4
<211>  360
<212>  PRT
<213>  Entamoeba histolytica

<400>  4

Met Lys Gly Leu Ala Met Leu Gly Ile Gly Arg Ile Gly Trp Ile Glu 
1               5                   10                  15      


Lys Lys Ile Pro Glu Cys Gly Pro Leu Asp Ala Leu Val Arg Pro Leu 
            20                  25                  30          


Ala Leu Ala Pro Cys Thr Ser Asp Thr His Thr Val Trp Ala Gly Ala 
        35                  40                  45              


Ile Gly Asp Arg His Asp Met Ile Leu Gly His Glu Ala Val Gly Gln 
    50                  55                  60                  


Ile Val Lys Val Gly Ser Leu Val Lys Arg Leu Lys Val Gly Asp Lys 
65                  70                  75                  80  


Val Ile Val Pro Ala Ile Thr Pro Asp Trp Gly Glu Glu Glu Ser Gln 
                85                  90                  95      


Arg Gly Tyr Pro Met His Ser Gly Gly Met Leu Gly Gly Trp Lys Phe 
            100                 105                 110         


Ser Asn Phe Lys Asp Gly Val Phe Ser Glu Val Phe His Val Asn Glu 
        115                 120                 125             


Ala Asp Ala Asn Leu Ala Leu Leu Pro Arg Asp Ile Lys Pro Glu Asp 
    130                 135                 140                 


Ala Val Met Leu Ser Asp Met Val Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 


Leu Ala Asn Ile Lys Leu Gly Asp Thr Val Cys Val Ile Gly Ile Gly 
                165                 170                 175     


Pro Val Gly Leu Met Ser Val Ala Gly Ala Asn His Leu Gly Ala Gly 
            180                 185                 190         


Arg Ile Phe Ala Val Gly Ser Arg Lys His Cys Cys Asp Ile Ala Leu 
        195                 200                 205             


Glu Tyr Gly Ala Thr Asp Ile Ile Asn Tyr Lys Asn Gly Asp Ile Val 
    210                 215                 220                 


Glu Gln Ile Leu Lys Ala Thr Asp Gly Lys Gly Val Asp Lys Val Val 
225                 230                 235                 240 


Ile Ala Gly Gly Asp Val His Thr Phe Ala Gln Ala Val Lys Met Ile 
                245                 250                 255     


Lys Pro Gly Ser Asp Ile Gly Asn Val Asn Tyr Leu Gly Glu Gly Asp 
            260                 265                 270         


Asn Ile Asp Ile Pro Arg Ser Glu Trp Gly Val Gly Met Gly His Lys 
        275                 280                 285             


His Ile His Gly Gly Leu Thr Pro Gly Gly Arg Val Arg Met Glu Lys 
    290                 295                 300                 


Leu Ala Ser Leu Ile Ser Thr Gly Lys Leu Asp Thr Ser Lys Leu Ile 
305                 310                 315                 320 


Thr His Arg Phe Glu Gly Leu Glu Lys Val Glu Asp Ala Leu Met Leu 
                325                 330                 335     


Met Lys Asn Lys Pro Ala Asp Leu Ile Lys Pro Val Val Arg Ile His 
            340                 345                 350         


Tyr Asp Asp Glu Asp Thr Leu His 
        355                 360 


<210>  5
<211>  1710
<212>  DNA
<213>  Saccharomyces paradoxus


<220>
<221>  CDS
<222>  (1)..(1710)

<400>  5
atg aag gac tcc aag ttg tct aag ttc aag ggt aga ttc atg tcc aga         48
Met Lys Asp Ser Lys Leu Ser Lys Phe Lys Gly Arg Phe Met Ser Arg           
1               5                   10                  15                

act tct cat tgg ggt ttg act ggt caa aag ttg aga tac ttc att acc         96
Thr Ser His Trp Gly Leu Thr Gly Gln Lys Leu Arg Tyr Phe Ile Thr           
            20                  25                  30                    

att gct tct atg acc ggt ttc tct ttg ttt ggt tat gac caa ggt ttg        144
Ile Ala Ser Met Thr Gly Phe Ser Leu Phe Gly Tyr Asp Gln Gly Leu           
        35                  40                  45                        

atg gcc tct ttg att act ggt aag caa ttc aac tac gaa ttc cca gct        192
Met Ala Ser Leu Ile Thr Gly Lys Gln Phe Asn Tyr Glu Phe Pro Ala           
    50                  55                  60                            

acc aaa gaa aac ggt gat cat gat aga cat gct acc gtt gtt caa ggt        240
Thr Lys Glu Asn Gly Asp His Asp Arg His Ala Thr Val Val Gln Gly           
65                  70                  75                  80            

gct act act tct tgt tat gaa ttg ggt tgt ttc gcc ggt tct ttg ttc        288
Ala Thr Thr Ser Cys Tyr Glu Leu Gly Cys Phe Ala Gly Ser Leu Phe           
                85                  90                  95                

gtt atg ttt tac ggt gaa aga atc ggt aga aag cca ttg att ttg atg        336
Val Met Phe Tyr Gly Glu Arg Ile Gly Arg Lys Pro Leu Ile Leu Met           
            100                 105                 110                   

ggt tcc att atc acc att atc ggt gct gtt att tct acc tgt gct ttc        384
Gly Ser Ile Ile Thr Ile Ile Gly Ala Val Ile Ser Thr Cys Ala Phe           
        115                 120                 125                       

aga gat tat tgg gct ttg ggt caa ttc atc gtt ggt aga gtt gtt act        432
Arg Asp Tyr Trp Ala Leu Gly Gln Phe Ile Val Gly Arg Val Val Thr           
    130                 135                 140                           

ggt gtt ggt act ggt ttg aac act tct act att cca gtt tgg caa tcc        480
Gly Val Gly Thr Gly Leu Asn Thr Ser Thr Ile Pro Val Trp Gln Ser           
145                 150                 155                 160           

gaa atg tct aag gct gaa aac aga ggt ttg ttg gtt aac ttg gaa ggt        528
Glu Met Ser Lys Ala Glu Asn Arg Gly Leu Leu Val Asn Leu Glu Gly           
                165                 170                 175               

tcc act att gct ttc ggt act atg att gct tac tgg atc gat ttc ggt        576
Ser Thr Ile Ala Phe Gly Thr Met Ile Ala Tyr Trp Ile Asp Phe Gly           
            180                 185                 190                   

ttt tcc tac act aac tct tcc gtt caa tgg aga ttt cca gtc tct atg        624
Phe Ser Tyr Thr Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ser Met           
        195                 200                 205                       

caa atc gtt ttc gcc ttg ttt ttg ttg gcc ttc atg att aag ttg cca        672
Gln Ile Val Phe Ala Leu Phe Leu Leu Ala Phe Met Ile Lys Leu Pro           
    210                 215                 220                           

gaa tct cca aga tgg ttg atc tct caa tct aga act gaa gaa gcc aga        720
Glu Ser Pro Arg Trp Leu Ile Ser Gln Ser Arg Thr Glu Glu Ala Arg           
225                 230                 235                 240           

tac ttg gtt ggt act ttg gat gat act gat cca aac gat gaa gaa gtt        768
Tyr Leu Val Gly Thr Leu Asp Asp Thr Asp Pro Asn Asp Glu Glu Val           
                245                 250                 255               

att acc gaa gtt gcc atg ttg cat gat gcc gtt aat aga act aag cac        816
Ile Thr Glu Val Ala Met Leu His Asp Ala Val Asn Arg Thr Lys His           
            260                 265                 270                   

gaa aag cac tca ttg tca tcc ttg ttt tct aga ggt aag tcc caa aac        864
Glu Lys His Ser Leu Ser Ser Leu Phe Ser Arg Gly Lys Ser Gln Asn           
        275                 280                 285                       

ttg caa aga gct ttg att gct gct tct acc caa ttc ttc caa caa ttc        912
Leu Gln Arg Ala Leu Ile Ala Ala Ser Thr Gln Phe Phe Gln Gln Phe           
    290                 295                 300                           

act ggt tgt aat gct gcc atc tac tac tct act gtt ttg ttc aac aag        960
Thr Gly Cys Asn Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Asn Lys           
305                 310                 315                 320           

acc atc aag ttg gac cac aga ttg tcc atg att att ggt ggt gtt ttc       1008
Thr Ile Lys Leu Asp His Arg Leu Ser Met Ile Ile Gly Gly Val Phe           
                325                 330                 335               

gct act atc tac gcc ttg tct act att ggt tcc ttc ttc ttg atc gaa       1056
Ala Thr Ile Tyr Ala Leu Ser Thr Ile Gly Ser Phe Phe Leu Ile Glu           
            340                 345                 350                   

aaa tta ggt aga aga aag ttg ttc ttg ttg ggt gct act ggt caa gct       1104
Lys Leu Gly Arg Arg Lys Leu Phe Leu Leu Gly Ala Thr Gly Gln Ala           
        355                 360                 365                       

gtt tct ttc act att acc ttt gct tgc ttg gta aaa gaa aac aaa gaa       1152
Val Ser Phe Thr Ile Thr Phe Ala Cys Leu Val Lys Glu Asn Lys Glu           
    370                 375                 380                           

aat gct aga ggt gct gcc gtt ggt ttg ttc tta ttc att act ttc ttc       1200
Asn Ala Arg Gly Ala Ala Val Gly Leu Phe Leu Phe Ile Thr Phe Phe           
385                 390                 395                 400           

ggt ttg tcc ttg ttg tct ttg cca tgg atc tat cca cca gaa att gct       1248
Gly Leu Ser Leu Leu Ser Leu Pro Trp Ile Tyr Pro Pro Glu Ile Ala           
                405                 410                 415               

tca atg aag gtt aga gca tct acc aat gct ttc tct act tgt aca aac       1296
Ser Met Lys Val Arg Ala Ser Thr Asn Ala Phe Ser Thr Cys Thr Asn           
            420                 425                 430                   

tgg ttg tgc aat ttc gcc gtt gtt atg ttc acc cca att ttc att ggt       1344
Trp Leu Cys Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Gly           
        435                 440                 445                       

caa tct ggt tgg ggt tgt tac ttg ttt ttt gcc gtt atg aac tac ttg       1392
Gln Ser Gly Trp Gly Cys Tyr Leu Phe Phe Ala Val Met Asn Tyr Leu           
    450                 455                 460                           

tat atc cca gtt ata ttc ttt ttc tac cct gaa acc gct ggt aga tcc       1440
Tyr Ile Pro Val Ile Phe Phe Phe Tyr Pro Glu Thr Ala Gly Arg Ser           
465                 470                 475                 480           

ttg gaa gaa att gat att atc ttc gcc aag gcc tac gaa gat ggt act       1488
Leu Glu Glu Ile Asp Ile Ile Phe Ala Lys Ala Tyr Glu Asp Gly Thr           
                485                 490                 495               

caa cct tgg aga gtt gct aat cat ttg cca aag ttg tcc ttg caa gaa       1536
Gln Pro Trp Arg Val Ala Asn His Leu Pro Lys Leu Ser Leu Gln Glu           
            500                 505                 510                   

gtt gaa gat cac gct aat gct ttg ggt tct tat gat gac gaa atg gaa       1584
Val Glu Asp His Ala Asn Ala Leu Gly Ser Tyr Asp Asp Glu Met Glu           
        515                 520                 525                       

aag gat gat ttc gcc gaa gat aga gtc gaa gat acc tac aat caa atc       1632
Lys Asp Asp Phe Ala Glu Asp Arg Val Glu Asp Thr Tyr Asn Gln Ile           
    530                 535                 540                           

aac ggt gac aac tcc tct tcc tcc tct aat atc aaa aac gaa gat act       1680
Asn Gly Asp Asn Ser Ser Ser Ser Ser Asn Ile Lys Asn Glu Asp Thr           
545                 550                 555                 560           

gtt aac gac aag gcc aac tct gaa tct tga                               1710
Val Asn Asp Lys Ala Asn Ser Glu Ser                                       
                565                                                       


<210>  6
<211>  569
<212>  PRT
<213>  Saccharomyces paradoxus

<400>  6

Met Lys Asp Ser Lys Leu Ser Lys Phe Lys Gly Arg Phe Met Ser Arg 
1               5                   10                  15      


Thr Ser His Trp Gly Leu Thr Gly Gln Lys Leu Arg Tyr Phe Ile Thr 
            20                  25                  30          


Ile Ala Ser Met Thr Gly Phe Ser Leu Phe Gly Tyr Asp Gln Gly Leu 
        35                  40                  45              


Met Ala Ser Leu Ile Thr Gly Lys Gln Phe Asn Tyr Glu Phe Pro Ala 
    50                  55                  60                  


Thr Lys Glu Asn Gly Asp His Asp Arg His Ala Thr Val Val Gln Gly 
65                  70                  75                  80  


Ala Thr Thr Ser Cys Tyr Glu Leu Gly Cys Phe Ala Gly Ser Leu Phe 
                85                  90                  95      


Val Met Phe Tyr Gly Glu Arg Ile Gly Arg Lys Pro Leu Ile Leu Met 
            100                 105                 110         


Gly Ser Ile Ile Thr Ile Ile Gly Ala Val Ile Ser Thr Cys Ala Phe 
        115                 120                 125             


Arg Asp Tyr Trp Ala Leu Gly Gln Phe Ile Val Gly Arg Val Val Thr 
    130                 135                 140                 


Gly Val Gly Thr Gly Leu Asn Thr Ser Thr Ile Pro Val Trp Gln Ser 
145                 150                 155                 160 


Glu Met Ser Lys Ala Glu Asn Arg Gly Leu Leu Val Asn Leu Glu Gly 
                165                 170                 175     


Ser Thr Ile Ala Phe Gly Thr Met Ile Ala Tyr Trp Ile Asp Phe Gly 
            180                 185                 190         


Phe Ser Tyr Thr Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ser Met 
        195                 200                 205             


Gln Ile Val Phe Ala Leu Phe Leu Leu Ala Phe Met Ile Lys Leu Pro 
    210                 215                 220                 


Glu Ser Pro Arg Trp Leu Ile Ser Gln Ser Arg Thr Glu Glu Ala Arg 
225                 230                 235                 240 


Tyr Leu Val Gly Thr Leu Asp Asp Thr Asp Pro Asn Asp Glu Glu Val 
                245                 250                 255     


Ile Thr Glu Val Ala Met Leu His Asp Ala Val Asn Arg Thr Lys His 
            260                 265                 270         


Glu Lys His Ser Leu Ser Ser Leu Phe Ser Arg Gly Lys Ser Gln Asn 
        275                 280                 285             


Leu Gln Arg Ala Leu Ile Ala Ala Ser Thr Gln Phe Phe Gln Gln Phe 
    290                 295                 300                 


Thr Gly Cys Asn Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Asn Lys 
305                 310                 315                 320 


Thr Ile Lys Leu Asp His Arg Leu Ser Met Ile Ile Gly Gly Val Phe 
                325                 330                 335     


Ala Thr Ile Tyr Ala Leu Ser Thr Ile Gly Ser Phe Phe Leu Ile Glu 
            340                 345                 350         


Lys Leu Gly Arg Arg Lys Leu Phe Leu Leu Gly Ala Thr Gly Gln Ala 
        355                 360                 365             


Val Ser Phe Thr Ile Thr Phe Ala Cys Leu Val Lys Glu Asn Lys Glu 
    370                 375                 380                 


Asn Ala Arg Gly Ala Ala Val Gly Leu Phe Leu Phe Ile Thr Phe Phe 
385                 390                 395                 400 


Gly Leu Ser Leu Leu Ser Leu Pro Trp Ile Tyr Pro Pro Glu Ile Ala 
                405                 410                 415     


Ser Met Lys Val Arg Ala Ser Thr Asn Ala Phe Ser Thr Cys Thr Asn 
            420                 425                 430         


Trp Leu Cys Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Gly 
        435                 440                 445             


Gln Ser Gly Trp Gly Cys Tyr Leu Phe Phe Ala Val Met Asn Tyr Leu 
    450                 455                 460                 


Tyr Ile Pro Val Ile Phe Phe Phe Tyr Pro Glu Thr Ala Gly Arg Ser 
465                 470                 475                 480 


Leu Glu Glu Ile Asp Ile Ile Phe Ala Lys Ala Tyr Glu Asp Gly Thr 
                485                 490                 495     


Gln Pro Trp Arg Val Ala Asn His Leu Pro Lys Leu Ser Leu Gln Glu 
            500                 505                 510         


Val Glu Asp His Ala Asn Ala Leu Gly Ser Tyr Asp Asp Glu Met Glu 
        515                 520                 525             


Lys Asp Asp Phe Ala Glu Asp Arg Val Glu Asp Thr Tyr Asn Gln Ile 
    530                 535                 540                 


Asn Gly Asp Asn Ser Ser Ser Ser Ser Asn Ile Lys Asn Glu Asp Thr 
545                 550                 555                 560 


Val Asn Asp Lys Ala Asn Ser Glu Ser 
                565                 


<210>  7
<211>  1713
<212>  DNA
<213>  Pichia sorbitophila


<220>
<221>  CDS
<222>  (1)..(1713)

<400>  7
atg gga ttc gaa ctt tgg gga agg acc aac aca ggt ggt ttg aga ggt         48
Met Gly Phe Glu Leu Trp Gly Arg Thr Asn Thr Gly Gly Leu Arg Gly           
1               5                   10                  15                

aga cct ctt cgt gtt gcc atc acc gct gtt gca act act ggt ttc tcc         96
Arg Pro Leu Arg Val Ala Ile Thr Ala Val Ala Thr Thr Gly Phe Ser           
            20                  25                  30                    

ctt ttc ggt tat gat cag ggt ttg atg tct ggt att att acc ggt act        144
Leu Phe Gly Tyr Asp Gln Gly Leu Met Ser Gly Ile Ile Thr Gly Thr           
        35                  40                  45                        

gaa ttt aac gag gag ttc cct cca acc tgg tcc aag cca cat tac aac        192
Glu Phe Asn Glu Glu Phe Pro Pro Thr Trp Ser Lys Pro His Tyr Asn           
    50                  55                  60                            

gcg tct gag aag aga cat gct act gtt gtt caa ggt gct gtt aca gct        240
Ala Ser Glu Lys Arg His Ala Thr Val Val Gln Gly Ala Val Thr Ala           
65                  70                  75                  80            

tgt tac gaa att ggt tgt ttc ttc ggt gct ctt ttt gct ttg gtt aga        288
Cys Tyr Glu Ile Gly Cys Phe Phe Gly Ala Leu Phe Ala Leu Val Arg           
                85                  90                  95                

ggt gac agg atc ggt aga cgt cca ctt gtc att gtt ggt gct gtt ctt        336
Gly Asp Arg Ile Gly Arg Arg Pro Leu Val Ile Val Gly Ala Val Leu           
            100                 105                 110                   

atc atc att ggt act gtt att tct act gct gct ttt ggt gaa cac tgg        384
Ile Ile Ile Gly Thr Val Ile Ser Thr Ala Ala Phe Gly Glu His Trp           
        115                 120                 125                       

ggt ttg ggt caa ttc gtt att ggt aga gtt att act ggt att ggt aac        432
Gly Leu Gly Gln Phe Val Ile Gly Arg Val Ile Thr Gly Ile Gly Asn           
    130                 135                 140                           

ggt atg aac aca gca act atc cca gtc tgg caa tct gag atc tct cgt        480
Gly Met Asn Thr Ala Thr Ile Pro Val Trp Gln Ser Glu Ile Ser Arg           
145                 150                 155                 160           

cca gaa aac aga ggt aag tta gtc aac ttg gaa ggt tca gtc att gcc        528
Pro Glu Asn Arg Gly Lys Leu Val Asn Leu Glu Gly Ser Val Ile Ala           
                165                 170                 175               

att ggt act ttc gtt gct tac tgg att gat ttc ggt ctc tcc tac gtt        576
Ile Gly Thr Phe Val Ala Tyr Trp Ile Asp Phe Gly Leu Ser Tyr Val           
            180                 185                 190                   

aac agc tct gta caa tgg aga ttc cct gtt gcg ttc caa att gtt ttt        624
Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ala Phe Gln Ile Val Phe           
        195                 200                 205                       

gct gct gga ctt ctt gga ggt att ctt ttc atg ccg gag tct cct aga        672
Ala Ala Gly Leu Leu Gly Gly Ile Leu Phe Met Pro Glu Ser Pro Arg           
    210                 215                 220                           

tgg ttg ctc gct cat ggc aag aag gag caa gca cac ata gtc tta ggt        720
Trp Leu Leu Ala His Gly Lys Lys Glu Gln Ala His Ile Val Leu Gly           
225                 230                 235                 240           

gct ttg aat gat ctc gac cct aat gat gac cat gtc ctt gct gag agt        768
Ala Leu Asn Asp Leu Asp Pro Asn Asp Asp His Val Leu Ala Glu Ser           
                245                 250                 255               

act gtt att acc gat gct att aac aga ttc tcc agg tct caa ctt ggt        816
Thr Val Ile Thr Asp Ala Ile Asn Arg Phe Ser Arg Ser Gln Leu Gly           
            260                 265                 270                   

ttc aag gaa ctt atg tcc ggt ggt aag aac caa cat ttt gct aga atg        864
Phe Lys Glu Leu Met Ser Gly Gly Lys Asn Gln His Phe Ala Arg Met           
        275                 280                 285                       

gtt att ggt tct tcc act caa ttt ttc caa cag ttc act ggt tgt aat        912
Val Ile Gly Ser Ser Thr Gln Phe Phe Gln Gln Phe Thr Gly Cys Asn           
    290                 295                 300                           

gct gcc att tac tat tca aca gtt ttg ttc gaa gag acc att ttc gtc        960
Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Glu Glu Thr Ile Phe Val           
305                 310                 315                 320           

ggt gac aga aga ttg tct ttg gtt atg ggt ggt gtt ttc gct tcc gta       1008
Gly Asp Arg Arg Leu Ser Leu Val Met Gly Gly Val Phe Ala Ser Val           
                325                 330                 335               

tac gcc ctt gcc act att cca tct ttc ttc tta gtc gat aag ctt ggt       1056
Tyr Ala Leu Ala Thr Ile Pro Ser Phe Phe Leu Val Asp Lys Leu Gly           
            340                 345                 350                   

aga aga aac ttg ttc ttg att ggt gct act ggt caa gct ttg tct ttc       1104
Arg Arg Asn Leu Phe Leu Ile Gly Ala Thr Gly Gln Ala Leu Ser Phe           
        355                 360                 365                       

acc att aca ttt gct tgt ttg atc aac cca aca aag caa aat gct aag       1152
Thr Ile Thr Phe Ala Cys Leu Ile Asn Pro Thr Lys Gln Asn Ala Lys           
    370                 375                 380                           

ggt gca gct gtt ggt atc ttc ttg ttt atc acc ttc ttc gcc ttt aca       1200
Gly Ala Ala Val Gly Ile Phe Leu Phe Ile Thr Phe Phe Ala Phe Thr           
385                 390                 395                 400           

att ttg cca ttg cct tgg att tac cca cca gaa atc aac cca ttg aga       1248
Ile Leu Pro Leu Pro Trp Ile Tyr Pro Pro Glu Ile Asn Pro Leu Arg           
                405                 410                 415               

aca aga act gtt gcc tct gcc gtt tct aca tgt acc aat tgg ctt aca       1296
Thr Arg Thr Val Ala Ser Ala Val Ser Thr Cys Thr Asn Trp Leu Thr           
            420                 425                 430                   

aac ttt gcc gtc gtt atg ttt act cct att ttc att aac gat gct caa       1344
Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Asn Asp Ala Gln           
        435                 440                 445                       

tgg ggt tgt tac ttg ttc ttt gct tgt ttg aac tac gct ttc att cca       1392
Trp Gly Cys Tyr Leu Phe Phe Ala Cys Leu Asn Tyr Ala Phe Ile Pro           
    450                 455                 460                           

gtt atc ttc tgg ttc tac cca gaa act gct ggc cgt tcc ttg gaa gaa       1440
Val Ile Phe Trp Phe Tyr Pro Glu Thr Ala Gly Arg Ser Leu Glu Glu           
465                 470                 475                 480           

att gat atc att ttc gcg aag gct tac act gat gga aga cct cca tgg       1488
Ile Asp Ile Ile Phe Ala Lys Ala Tyr Thr Asp Gly Arg Pro Pro Trp           
                485                 490                 495               

aga gtt gct gct acc atg cca cac ttg tct ttg aag gaa caa gag gag       1536
Arg Val Ala Ala Thr Met Pro His Leu Ser Leu Lys Glu Gln Glu Glu           
            500                 505                 510                   

caa ggt atg caa ctc gga ctt tat gac aat gaa gct gag aaa cag aag       1584
Gln Gly Met Gln Leu Gly Leu Tyr Asp Asn Glu Ala Glu Lys Gln Lys           
        515                 520                 525                       

ttc gag caa acc gag aac ttg atg tct tct agc tct tct gcg aag ctt       1632
Phe Glu Gln Thr Glu Asn Leu Met Ser Ser Ser Ser Ser Ala Lys Leu           
    530                 535                 540                           

cct gaa gag gga tct aac gta aac gag aat gag aac gaa aac acg aac       1680
Pro Glu Glu Gly Ser Asn Val Asn Glu Asn Glu Asn Glu Asn Thr Asn           
545                 550                 555                 560           

gaa aag gat caa aca cca aag cca act gat gtt                           1713
Glu Lys Asp Gln Thr Pro Lys Pro Thr Asp Val                               
                565                 570                                   


<210>  8
<211>  571
<212>  PRT
<213>  Pichia sorbitophila

<400>  8

Met Gly Phe Glu Leu Trp Gly Arg Thr Asn Thr Gly Gly Leu Arg Gly 
1               5                   10                  15      


Arg Pro Leu Arg Val Ala Ile Thr Ala Val Ala Thr Thr Gly Phe Ser 
            20                  25                  30          


Leu Phe Gly Tyr Asp Gln Gly Leu Met Ser Gly Ile Ile Thr Gly Thr 
        35                  40                  45              


Glu Phe Asn Glu Glu Phe Pro Pro Thr Trp Ser Lys Pro His Tyr Asn 
    50                  55                  60                  


Ala Ser Glu Lys Arg His Ala Thr Val Val Gln Gly Ala Val Thr Ala 
65                  70                  75                  80  


Cys Tyr Glu Ile Gly Cys Phe Phe Gly Ala Leu Phe Ala Leu Val Arg 
                85                  90                  95      


Gly Asp Arg Ile Gly Arg Arg Pro Leu Val Ile Val Gly Ala Val Leu 
            100                 105                 110         


Ile Ile Ile Gly Thr Val Ile Ser Thr Ala Ala Phe Gly Glu His Trp 
        115                 120                 125             


Gly Leu Gly Gln Phe Val Ile Gly Arg Val Ile Thr Gly Ile Gly Asn 
    130                 135                 140                 


Gly Met Asn Thr Ala Thr Ile Pro Val Trp Gln Ser Glu Ile Ser Arg 
145                 150                 155                 160 


Pro Glu Asn Arg Gly Lys Leu Val Asn Leu Glu Gly Ser Val Ile Ala 
                165                 170                 175     


Ile Gly Thr Phe Val Ala Tyr Trp Ile Asp Phe Gly Leu Ser Tyr Val 
            180                 185                 190         


Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ala Phe Gln Ile Val Phe 
        195                 200                 205             


Ala Ala Gly Leu Leu Gly Gly Ile Leu Phe Met Pro Glu Ser Pro Arg 
    210                 215                 220                 


Trp Leu Leu Ala His Gly Lys Lys Glu Gln Ala His Ile Val Leu Gly 
225                 230                 235                 240 


Ala Leu Asn Asp Leu Asp Pro Asn Asp Asp His Val Leu Ala Glu Ser 
                245                 250                 255     


Thr Val Ile Thr Asp Ala Ile Asn Arg Phe Ser Arg Ser Gln Leu Gly 
            260                 265                 270         


Phe Lys Glu Leu Met Ser Gly Gly Lys Asn Gln His Phe Ala Arg Met 
        275                 280                 285             


Val Ile Gly Ser Ser Thr Gln Phe Phe Gln Gln Phe Thr Gly Cys Asn 
    290                 295                 300                 


Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Glu Glu Thr Ile Phe Val 
305                 310                 315                 320 


Gly Asp Arg Arg Leu Ser Leu Val Met Gly Gly Val Phe Ala Ser Val 
                325                 330                 335     


Tyr Ala Leu Ala Thr Ile Pro Ser Phe Phe Leu Val Asp Lys Leu Gly 
            340                 345                 350         


Arg Arg Asn Leu Phe Leu Ile Gly Ala Thr Gly Gln Ala Leu Ser Phe 
        355                 360                 365             


Thr Ile Thr Phe Ala Cys Leu Ile Asn Pro Thr Lys Gln Asn Ala Lys 
    370                 375                 380                 


Gly Ala Ala Val Gly Ile Phe Leu Phe Ile Thr Phe Phe Ala Phe Thr 
385                 390                 395                 400 


Ile Leu Pro Leu Pro Trp Ile Tyr Pro Pro Glu Ile Asn Pro Leu Arg 
                405                 410                 415     


Thr Arg Thr Val Ala Ser Ala Val Ser Thr Cys Thr Asn Trp Leu Thr 
            420                 425                 430         


Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Asn Asp Ala Gln 
        435                 440                 445             


Trp Gly Cys Tyr Leu Phe Phe Ala Cys Leu Asn Tyr Ala Phe Ile Pro 
    450                 455                 460                 


Val Ile Phe Trp Phe Tyr Pro Glu Thr Ala Gly Arg Ser Leu Glu Glu 
465                 470                 475                 480 


Ile Asp Ile Ile Phe Ala Lys Ala Tyr Thr Asp Gly Arg Pro Pro Trp 
                485                 490                 495     


Arg Val Ala Ala Thr Met Pro His Leu Ser Leu Lys Glu Gln Glu Glu 
            500                 505                 510         


Gln Gly Met Gln Leu Gly Leu Tyr Asp Asn Glu Ala Glu Lys Gln Lys 
        515                 520                 525             


Phe Glu Gln Thr Glu Asn Leu Met Ser Ser Ser Ser Ser Ala Lys Leu 
    530                 535                 540                 


Pro Glu Glu Gly Ser Asn Val Asn Glu Asn Glu Asn Glu Asn Thr Asn 
545                 550                 555                 560 


Glu Lys Asp Gln Thr Pro Lys Pro Thr Asp Val 
                565                 570     


<210>  9
<211>  440
<212>  PRT
<213>  Catonella morbi

<400>  9

Met Ser Glu Leu Phe Gln Asn Ile Pro Lys Ile Lys Tyr Glu Gly Ala 
1               5                   10                  15      


Asn Ser Lys Asn Pro Leu Ala Phe His Tyr Tyr Asp Ala Glu Lys Ile 
            20                  25                  30          


Val Leu Gly Lys Thr Met Lys Glu His Leu Pro Phe Ala Met Ala Trp 
        35                  40                  45              


Trp His Asn Leu Cys Ala Ala Gly Thr Asp Met Phe Gly Arg Asp Thr 
    50                  55                  60                  


Ala Asp Lys Ser Phe Gly Leu Glu Lys Gly Ser Met Glu His Ala Lys 
65                  70                  75                  80  


Ala Lys Val Asp Ala Gly Phe Glu Phe Met Glu Lys Leu Gly Ile Lys 
                85                  90                  95      


Tyr Phe Cys Phe His Asp Val Asp Leu Val Pro Glu Ala Cys Asp Ile 
            100                 105                 110         


Lys Glu Thr Asn Ser Arg Leu Asp Glu Ile Ser Asp Tyr Ile Leu Glu 
        115                 120                 125             


Lys Met Lys Gly Thr Asp Ile Lys Cys Leu Trp Gly Thr Ala Asn Met 
    130                 135                 140                 


Phe Ser Asn Pro Arg Phe Val Asn Gly Ala Gly Ser Thr Asn Ser Ala 
145                 150                 155                 160 


Asp Val Tyr Cys Phe Ala Ala Ala Gln Ile Lys Lys Ala Leu Asp Ile 
                165                 170                 175     


Thr Val Lys Leu Gly Gly Arg Gly Tyr Val Phe Trp Gly Gly Arg Glu 
            180                 185                 190         


Gly Tyr Glu Thr Leu Leu Asn Thr Asp Val Lys Phe Glu Gln Glu Asn 
        195                 200                 205             


Ile Ala Asn Leu Met Lys Met Ala Val Glu Tyr Gly Arg Ser Ile Gly 
    210                 215                 220                 


Phe Lys Gly Asp Phe Tyr Ile Glu Pro Lys Pro Lys Glu Pro Met Lys 
225                 230                 235                 240 


His Gln Tyr Asp Phe Asp Ala Ala Thr Ala Ile Gly Phe Leu Arg Gln 
                245                 250                 255     


Tyr Gly Leu Asp Lys Asp Phe Lys Leu Asn Ile Glu Ala Asn His Ala 
            260                 265                 270         


Thr Leu Ala Gly His Ser Phe Gln His Glu Leu Arg Ile Ser Ser Ile 
        275                 280                 285             


Asn Gly Met Leu Gly Ser Val Asp Ala Asn Gln Gly Asp Met Leu Leu 
    290                 295                 300                 


Gly Trp Asp Thr Asp Glu Phe Pro Phe Asp Val Tyr Asp Thr Thr Met 
305                 310                 315                 320 


Cys Met Tyr Glu Val Leu Lys Asn Gly Gly Leu Thr Gly Gly Phe Asn 
                325                 330                 335     


Phe Asp Ala Lys Asn Arg Arg Pro Ser Tyr Thr Tyr Glu Asp Met Phe 
            340                 345                 350         


Tyr Gly Phe Ile Leu Gly Met Asp Ser Phe Ala Leu Gly Leu Ile Lys 
        355                 360                 365             


Ala Ala Lys Leu Ile Glu Glu Gly Thr Leu Asp Asn Phe Ile Lys Glu 
    370                 375                 380                 


Arg Tyr Lys Ser Phe Glu Ser Glu Ile Gly Lys Lys Ile Arg Ser Lys 
385                 390                 395                 400 


Ser Ala Ser Leu Gln Glu Leu Ala Ala Tyr Ala Glu Glu Met Gly Ala 
                405                 410                 415     


Pro Ala Met Pro Gly Ser Gly Arg Gln Glu Tyr Leu Gln Ala Ala Leu 
            420                 425                 430         


Asn Gln Asn Leu Phe Gly Glu Val 
        435                 440 


<210>  10
<211>  509
<212>  PRT
<213>  Bacteroides thetaiotaomicron

<400>  10

Met Asn Asn Val Phe Asp Gln Tyr Glu Val Trp Phe Val Thr Gly Ala 
1               5                   10                  15      


Gln Leu Leu Tyr Gly Gly Asp Ala Val Ile Ala Val Asp Ala His Ser 
            20                  25                  30          


Asn Glu Met Val Asn Gly Leu Asn Glu Ser Gly Lys Leu Pro Val Lys 
        35                  40                  45              


Val Val Tyr Lys Gly Thr Ala Asn Ser Ser Lys Glu Val Glu Ala Val 
    50                  55                  60                  


Phe Lys Ala Ala Asn Asn Asp Asp Lys Cys Val Gly Val Ile Thr Trp 
65                  70                  75                  80  


Met His Thr Phe Ser Pro Ala Lys Met Trp Ile His Gly Leu Gln Gln 
                85                  90                  95      


Leu Lys Lys Pro Leu Leu His Leu His Thr Gln Phe Asn Lys Glu Ile 
            100                 105                 110         


Pro Trp Asp Thr Met Asp Met Asp Phe Met Asn Leu Asn Gln Ser Ala 
        115                 120                 125             


His Gly Asp Arg Glu Phe Gly His Ile Cys Thr Arg Met Arg Ile Arg 
    130                 135                 140                 


Arg Lys Val Val Val Gly Tyr Trp Lys Glu Glu Glu Thr Leu His Lys 
145                 150                 155                 160 


Ile Ala Val Trp Met Arg Val Cys Ala Gly Trp Ala Asp Ser Gln Asp 
                165                 170                 175     


Met Leu Ile Ile Arg Phe Gly Asp Gln Met Asn Asn Val Ala Val Thr 
            180                 185                 190         


Asp Gly Asp Lys Val Glu Ala Glu Gln Arg Met Gly Tyr His Val Asp 
        195                 200                 205             


Tyr Cys Pro Ala Ser Glu Leu Met Glu Tyr His Lys Asp Ile Lys Asn 
    210                 215                 220                 


Ala Asp Val Asp Ala Leu Val Ala Thr Tyr Phe Asn Asp Tyr Asp His 
225                 230                 235                 240 


Asp Ala Ser Leu Glu Asp Lys Ser Thr Glu Ala Tyr Gln Lys Val Trp 
                245                 250                 255     


Asn Ala Ala Lys Ala Glu Leu Ala Leu Arg Ala Ile Leu Lys Ala Lys 
            260                 265                 270         


Gly Ala Lys Gly Phe Thr Thr Asn Phe Asp Asp Leu Gly Gln Thr Asp 
        275                 280                 285             


Gly Ser Tyr Phe Asp Gln Ile Pro Gly Leu Ala Ser Gln Arg Leu Met 
    290                 295                 300                 


Ala Glu Gly Tyr Gly Phe Gly Ala Glu Gly Asp Trp Lys Ser Ala Ala 
305                 310                 315                 320 


Leu Tyr Arg Thr Val Trp Val Met Asn Gln Gly Leu Pro Lys Gly Cys 
                325                 330                 335     


Ser Phe Leu Glu Asp Tyr Thr Leu Asn Phe Asp Gly Ala Asn Ser Ser 
            340                 345                 350         


Ile Leu Gln Ser His Met Leu Glu Ile Cys Pro Leu Ile Ala Ala Asn 
        355                 360                 365             


Lys Pro Arg Leu Glu Val His Phe Leu Gly Ile Gly Ile Arg Lys Ser 
    370                 375                 380                 


Gln Thr Ala Arg Leu Val Phe Thr Ser Lys Thr Gly Thr Gly Cys Thr 
385                 390                 395                 400 


Ala Thr Val Val Asp Met Gly Asn Arg Phe Arg Leu Ile Val Asn Asp 
                405                 410                 415     


Val Glu Cys Ile Glu Pro Lys Pro Leu Pro Lys Leu Pro Val Ala Ser 
            420                 425                 430         


Ala Leu Trp Ile Pro Met Pro Asn Leu Glu Val Gly Ala Gly Ala Trp 
        435                 440                 445             


Ile Leu Ala Gly Gly Thr His His Ser Cys Phe Ser Tyr Asp Leu Thr 
    450                 455                 460                 


Ala Glu Tyr Trp Glu Asp Tyr Ala Glu Ile Ala Gly Ile Glu Met Val 
465                 470                 475                 480 


His Ile Asn Lys Asp Thr Thr Ile Ser Cys Phe Lys Lys Glu Leu Arg 
                485                 490                 495     


Met Asn Glu Val Tyr Tyr Met Leu Asn Lys Ala Leu Cys 
            500                 505                 


<210>  11
<211>  531
<212>  PRT
<213>  Bacteroides thetaiotaomicron

<400>  11

Met Lys Leu Asp Ala Lys Ser Thr Ile Glu Thr Gly Lys Ala Ile Leu 
1               5                   10                  15      


Gly Ile Glu Leu Gly Ser Thr Arg Ile Lys Ala Val Leu Ile Asp Gln 
            20                  25                  30          


Glu Asn Lys Pro Ile Ala Gln Gly Ser His Thr Trp Glu Asn Gln Leu 
        35                  40                  45              


Val Asn Gly Leu Trp Thr Tyr Ser Ile Asp Ala Ile Trp Ser Gly Leu 
    50                  55                  60                  


Gln Asp Cys Tyr Ala Asp Leu Arg Ser Asn Val Lys Lys Leu Tyr Asp 
65                  70                  75                  80  


Thr Glu Ile Glu Thr Leu Ala Ala Ile Gly Val Ser Ala Met Met His 
                85                  90                  95      


Gly Tyr Met Pro Phe Asn Glu Lys Glu Glu Ile Leu Val Pro Phe Arg 
            100                 105                 110         


Thr Trp Arg Asn Thr Asn Thr Gly Arg Ala Ala Ala Glu Leu Ser Glu 
        115                 120                 125             


Leu Phe Val Tyr Asn Ile Pro Leu Arg Trp Ser Ile Ser His Leu Tyr 
    130                 135                 140                 


Gln Ala Ile Leu Asp Asn Glu Ala His Val Lys Asp Ile Lys Phe Leu 
145                 150                 155                 160 


Thr Thr Leu Ala Gly Tyr Val His Trp Gln Ile Thr Gly Glu Lys Val 
                165                 170                 175     


Leu Gly Ile Gly Asp Ala Ser Gly Met Leu Pro Ile Asp Pro Thr Thr 
            180                 185                 190         


Asn Asn Tyr Ser Ala Glu Met Val Ala Lys Phe Asn Asn Leu Ile Ala 
        195                 200                 205             


Ser Lys Glu Tyr Ser Trp Lys Leu Glu Asp Ile Leu Pro Lys Val Leu 
    210                 215                 220                 


Ser Ala Gly Glu Asn Ala Gly Val Leu Thr Pro Glu Gly Cys Lys Lys 
225                 230                 235                 240 


Leu Asp Ala Ser Gly His Leu Lys Ala Gly Ile Pro Val Cys Pro Pro 
                245                 250                 255     


Glu Gly Asp Ala Gly Thr Gly Met Val Ala Thr Asn Ala Val Lys Gln 
            260                 265                 270         


Arg Thr Gly Asn Val Ser Ala Gly Thr Ser Ser Phe Ser Met Ile Val 
        275                 280                 285             


Leu Glu Lys Glu Leu Ser Lys Pro Tyr Glu Met Ile Asp Met Val Thr 
    290                 295                 300                 


Thr Pro Asp Gly Ser Leu Val Ala Met Val His Cys Asn Asn Cys Thr 
305                 310                 315                 320 


Ser Asp Leu Asn Ala Trp Val Asn Leu Phe Lys Glu Tyr Gln Glu Leu 
                325                 330                 335     


Leu Gly Ile Pro Val Asp Met Asp Glu Leu Tyr Gly Lys Leu Tyr Asn 
            340                 345                 350         


Ile Ala Leu Thr Gly Asp Thr Asp Cys Gly Gly Leu Leu Ser Tyr Asn 
        355                 360                 365             


Tyr Ile Ser Gly Glu Pro Val Thr Gly Leu Ala Glu Gly Arg Pro Leu 
    370                 375                 380                 


Phe Val Arg Ser Ala Asn Asp Lys Phe Asn Leu Ala Asn Phe Met Arg 
385                 390                 395                 400 


Ala His Leu Tyr Ala Ser Val Gly Val Leu Lys Ile Gly Asn Asp Ile 
                405                 410                 415     


Leu Phe Asn Glu Glu Lys Ile Lys Val Asp Arg Ile Thr Gly His Gly 
            420                 425                 430         


Gly Leu Phe Arg Thr Lys Gly Val Gly Gln Arg Val Leu Ala Ala Ala 
        435                 440                 445             


Ile Asn Ser Pro Ile Ser Val Met Glu Thr Ala Gly Glu Gly Gly Ala 
    450                 455                 460                 


Trp Gly Ile Ala Leu Leu Gly Ser Tyr Leu Val Asn Asn Lys Lys Gly 
465                 470                 475                 480 


Gln Ser Leu Ala Asp Phe Leu Asp Glu Ser Val Phe Val Ser Asp Ala 
                485                 490                 495     


Gly Val Glu Val Ser Pro Thr Pro Glu Asp Val Ala Gly Phe Asn Thr 
            500                 505                 510         


Tyr Ile Glu Ser Tyr Lys Ala Gly Leu Pro Ile Glu Glu Ala Ala Val 
        515                 520                 525             


Lys Phe Lys 
    530     


<210>  12
<211>  227
<212>  PRT
<213>  Bacteroides thetaiotaomicron

<400>  12

Met Leu Glu Glu Leu Lys Glu Lys Val Phe His Ala Asn Leu Glu Leu 
1               5                   10                  15      


Val Lys His Gly Leu Val Ile Phe Thr Trp Gly Asn Val Ser Ala Ile 
            20                  25                  30          


Asp Arg Glu Thr Glu Leu Val Val Ile Lys Pro Ser Gly Val Ser Tyr 
        35                  40                  45              


Asp Asp Met Lys Ala Glu Asp Met Val Val Val Asp Leu Asp Gly Lys 
    50                  55                  60                  


Val Val Glu Gly Arg Leu Lys Pro Ser Ser Asp Thr Pro Thr His Val 
65                  70                  75                  80  


Val Leu Tyr Lys Ala Phe Pro Glu Ile Gly Gly Val Val His Thr His 
                85                  90                  95      


Ser Thr Tyr Ala Thr Ala Trp Ala Gln Ala Gly Cys Asp Ile Pro Asn 
            100                 105                 110         


Ile Gly Thr Thr His Ala Asp Tyr Phe His Asp Ala Ile Pro Cys Thr 
        115                 120                 125             


Ala Asp Met Thr Glu Ala Glu Val Lys Gly Ala Tyr Glu Leu Glu Thr 
    130                 135                 140                 


Gly Asn Val Ile Val Lys Arg Phe Glu Gly Leu Asn Pro Val His Thr 
145                 150                 155                 160 


Pro Gly Val Leu Val Lys Asn His Gly Pro Phe Ser Trp Gly Lys Asp 
                165                 170                 175     


Ala His Asp Ala Val His Asn Ala Val Val Met Glu Gln Val Ala Lys 
            180                 185                 190         


Met Ala Ser Ile Ala Tyr Ala Val Asn Pro Asn Leu Thr Met Asn Pro 
        195                 200                 205             


Leu Leu Val Glu Lys His Phe Ser Arg Lys His Gly Pro Asn Ala Tyr 
    210                 215                 220                 


Tyr Gly Gln 
225         


<210>  13
<211>  489
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Ser Ala Asp Phe Gly Leu Ile Gly Leu Ala Val Met Gly Gln Asn 
1               5                   10                  15      


Leu Ile Leu Asn Ala Ala Asp His Gly Phe Thr Val Cys Ala Tyr Asn 
            20                  25                  30          


Arg Thr Gln Ser Lys Val Asp His Phe Leu Ala Asn Glu Ala Lys Gly 
        35                  40                  45              


Lys Ser Ile Ile Gly Ala Thr Ser Ile Glu Asp Phe Ile Ser Lys Leu 
    50                  55                  60                  


Lys Arg Pro Arg Lys Val Met Leu Leu Val Lys Ala Gly Ala Pro Val 
65                  70                  75                  80  


Asp Ala Leu Ile Asn Gln Ile Val Pro Leu Leu Glu Lys Gly Asp Ile 
                85                  90                  95      


Ile Ile Asp Gly Gly Asn Ser His Phe Pro Asp Ser Asn Arg Arg Tyr 
            100                 105                 110         


Glu Glu Leu Lys Lys Lys Gly Ile Leu Phe Val Gly Ser Gly Val Ser 
        115                 120                 125             


Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly Gly 
    130                 135                 140                 


Ser Glu Glu Ala Trp Pro His Ile Lys Asn Ile Phe Gln Ser Ile Ser 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Glu Pro Cys Cys Glu Trp Val Gly Pro Ala Gly 
                165                 170                 175     


Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr Gly Asp 
            180                 185                 190         


Met Gln Leu Ile Cys Glu Ala Tyr Asp Ile Met Lys Arg Leu Gly Gly 
        195                 200                 205             


Phe Thr Asp Lys Glu Ile Ser Asp Val Phe Ala Lys Trp Asn Asn Gly 
    210                 215                 220                 


Val Leu Asp Ser Phe Leu Val Glu Ile Thr Arg Asp Ile Leu Lys Phe 
225                 230                 235                 240 


Asp Asp Val Asp Gly Lys Pro Leu Val Glu Lys Ile Met Asp Thr Ala 
                245                 250                 255     


Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Asn Ala Leu Asp Leu 
            260                 265                 270         


Gly Met Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg Cys Leu 
        275                 280                 285             


Ser Ala Leu Lys Asn Glu Arg Ile Arg Ala Ser Lys Val Leu Pro Gly 
    290                 295                 300                 


Pro Glu Val Pro Lys Asp Ala Val Lys Asp Arg Glu Gln Phe Val Asp 
305                 310                 315                 320 


Asp Leu Glu Gln Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala Gln 
                325                 330                 335     


Gly Phe Met Leu Ile Arg Glu Ala Ala Ala Thr Tyr Gly Trp Lys Leu 
            340                 345                 350         


Asn Asn Pro Ala Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile Arg 
        355                 360                 365             


Ser Val Phe Leu Gly Gln Ile Thr Lys Ala Tyr Arg Glu Glu Pro Asp 
    370                 375                 380                 


Leu Glu Asn Leu Leu Phe Asn Lys Phe Phe Ala Asp Ala Val Thr Lys 
385                 390                 395                 400 


Ala Gln Ser Gly Trp Arg Lys Ser Ile Ala Leu Ala Thr Thr Tyr Gly 
                405                 410                 415     


Ile Pro Thr Pro Ala Phe Ser Thr Ala Leu Ser Phe Tyr Asp Gly Tyr 
            420                 425                 430         


Arg Ser Glu Arg Leu Pro Ala Asn Leu Leu Gln Ala Gln Arg Asp Tyr 
        435                 440                 445             


Phe Gly Ala His Thr Phe Arg Val Leu Pro Glu Cys Ala Ser Asp Asn 
    450                 455                 460                 


Leu Pro Val Asp Lys Asp Ile His Ile Asn Trp Thr Gly His Gly Gly 
465                 470                 475                 480 


Asn Val Ser Ser Ser Thr Tyr Gln Ala 
                485                 


<210>  14
<211>  258
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Ala Ala Gly Val Pro Lys Ile Asp Ala Leu Glu Ser Leu Gly Asn 
1               5                   10                  15      


Pro Leu Glu Asp Ala Lys Arg Ala Ala Ala Tyr Arg Ala Val Asp Glu 
            20                  25                  30          


Asn Leu Lys Phe Asp Asp His Lys Ile Ile Gly Ile Gly Ser Gly Ser 
        35                  40                  45              


Thr Val Val Tyr Val Ala Glu Arg Ile Gly Gln Tyr Leu His Asp Pro 
    50                  55                  60                  


Lys Phe Tyr Glu Val Ala Ser Lys Phe Ile Cys Ile Pro Thr Gly Phe 
65                  70                  75                  80  


Gln Ser Arg Asn Leu Ile Leu Asp Asn Lys Leu Gln Leu Gly Ser Ile 
                85                  90                  95      


Glu Gln Tyr Pro Arg Ile Asp Ile Ala Phe Asp Gly Ala Asp Glu Val 
            100                 105                 110         


Asp Glu Asn Leu Gln Leu Ile Lys Gly Gly Gly Ala Cys Leu Phe Gln 
        115                 120                 125             


Glu Lys Leu Val Ser Thr Ser Ala Lys Thr Phe Ile Val Val Ala Asp 
    130                 135                 140                 


Ser Arg Lys Lys Ser Pro Lys His Leu Gly Lys Asn Trp Arg Gln Gly 
145                 150                 155                 160 


Val Pro Ile Glu Ile Val Pro Ser Ser Tyr Val Arg Val Lys Asn Asp 
                165                 170                 175     


Leu Leu Glu Gln Leu His Ala Glu Lys Val Asp Ile Arg Gln Gly Gly 
            180                 185                 190         


Ser Ala Lys Ala Gly Pro Val Val Thr Asp Asn Asn Asn Phe Ile Ile 
        195                 200                 205             


Asp Ala Asp Phe Gly Glu Ile Ser Asp Pro Arg Lys Leu His Arg Glu 
    210                 215                 220                 


Ile Lys Leu Leu Val Gly Val Val Glu Thr Gly Leu Phe Ile Asp Asn 
225                 230                 235                 240 


Ala Ser Lys Ala Tyr Phe Gly Asn Ser Asp Gly Ser Val Glu Val Thr 
                245                 250                 255     


Glu Lys 
        


<210>  15
<211>  238
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala 
1               5                   10                  15      


Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp 
            20                  25                  30          


Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu 
        35                  40                  45              


Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly 
    50                  55                  60                  


Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His 
65                  70                  75                  80  


Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys 
                85                  90                  95      


Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu 
            100                 105                 110         


His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala 
        115                 120                 125             


Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His 
    130                 135                 140                 


Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln 
145                 150                 155                 160 


Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys 
                165                 170                 175     


Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr 
            180                 185                 190         


Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr 
        195                 200                 205             


Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys 
    210                 215                 220                 


Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp 
225                 230                 235             


<210>  16
<211>  249
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  16

Met Val Thr Val Gly Val Phe Ser Glu Arg Ala Ser Leu Thr His Gln 
1               5                   10                  15      


Leu Gly Glu Phe Ile Val Lys Lys Gln Asp Glu Ala Leu Gln Lys Lys 
            20                  25                  30          


Ser Asp Phe Lys Val Ser Val Ser Gly Gly Ser Leu Ile Asp Ala Leu 
        35                  40                  45              


Tyr Glu Ser Leu Val Ala Asp Glu Ser Leu Ser Ser Arg Val Gln Trp 
    50                  55                  60                  


Ser Lys Trp Gln Ile Tyr Phe Ser Asp Glu Arg Ile Val Pro Leu Thr 
65                  70                  75                  80  


Asp Ala Asp Ser Asn Tyr Gly Ala Phe Lys Arg Ala Val Leu Asp Lys 
                85                  90                  95      


Leu Pro Ser Thr Ser Gln Pro Asn Val Tyr Pro Met Asp Glu Ser Leu 
            100                 105                 110         


Ile Gly Ser Asp Ala Glu Ser Asn Asn Lys Ile Ala Ala Glu Tyr Glu 
        115                 120                 125             


His Ile Val Pro Gln Val Leu Asp Leu Val Leu Leu Gly Cys Gly Pro 
    130                 135                 140                 


Asp Gly His Thr Cys Ser Leu Phe Pro Gly Glu Thr His Arg Tyr Leu 
145                 150                 155                 160 


Leu Asn Glu Thr Thr Lys Arg Val Ala Trp Cys His Asp Ser Pro Lys 
                165                 170                 175     


Pro Pro Ser Asp Arg Ile Thr Phe Thr Leu Pro Val Leu Lys Asp Ala 
            180                 185                 190         


Lys Ala Leu Cys Phe Val Ala Glu Gly Ser Ser Lys Gln Asn Ile Met 
        195                 200                 205             


His Glu Ile Phe Asp Leu Lys Asn Asp Gln Leu Pro Thr Ala Leu Val 
    210                 215                 220                 


Asn Lys Leu Phe Gly Glu Lys Thr Ser Trp Phe Val Asn Glu Glu Ala 
225                 230                 235                 240 


Phe Gly Lys Val Gln Thr Lys Thr Phe 
                245                 


<210>  17
<211>  335
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu 
1               5                   10                  15      


Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp 
            20                  25                  30          


Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro 
        35                  40                  45              


Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile 
    50                  55                  60                  


Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu 
65                  70                  75                  80  


Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu 
                85                  90                  95      


Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg 
            100                 105                 110         


Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile 
        115                 120                 125             


Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys 
    130                 135                 140                 


Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu 
145                 150                 155                 160 


Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln 
                165                 170                 175     


Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val 
            180                 185                 190         


Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys 
        195                 200                 205             


Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr 
    210                 215                 220                 


Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg 
225                 230                 235                 240 


Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile 
                245                 250                 255     


Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro 
            260                 265                 270         


Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile 
        275                 280                 285             


Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp 
    290                 295                 300                 


Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala 
305                 310                 315                 320 


Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala 
                325                 330                 335 


<210>  18
<211>  680
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg 
1               5                   10                  15      


Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly 
            20                  25                  30          


Ala Pro Leu Gly Met Ala Pro Ala Ala His Val Leu Trp Ser Gln Met 
        35                  40                  45              


Arg Met Asn Pro Thr Asn Pro Asp Trp Ile Asn Arg Asp Arg Phe Val 
    50                  55                  60                  


Leu Ser Asn Gly His Ala Val Ala Leu Leu Tyr Ser Met Leu His Leu 
65                  70                  75                  80  


Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu 
                85                  90                  95      


Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu 
            100                 105                 110         


Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met 
        115                 120                 125             


Ala Met Ala Gln Ala Asn Leu Ala Ala Thr Tyr Asn Lys Pro Gly Phe 
    130                 135                 140                 


Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys Leu 
145                 150                 155                 160 


Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu Lys 
                165                 170                 175     


Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile Asp 
            180                 185                 190         


Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr Glu 
        195                 200                 205             


Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp Leu 
    210                 215                 220                 


Ala Gly Ile Ala Lys Ala Ile Ala Gln Ala Lys Leu Ser Lys Asp Lys 
225                 230                 235                 240 


Pro Thr Leu Ile Lys Met Thr Thr Thr Ile Gly Tyr Gly Ser Leu His 
                245                 250                 255     


Ala Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp Val 
            260                 265                 270         


Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Gln Asp Lys Ser Phe Val 
        275                 280                 285             


Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys Pro 
    290                 295                 300                 


Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr Gln 
305                 310                 315                 320 


Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser Gly 
                325                 330                 335     


Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala Lys 
            340                 345                 350         


Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu Asp 
        355                 360                 365             


Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu Thr 
    370                 375                 380                 


Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala Leu Asp Phe Gln Pro Pro 
385                 390                 395                 400 


Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg Tyr Ile Arg Tyr Gly Ile 
                405                 410                 415     


Arg Glu His Ala Met Gly Ala Ile Met Asn Gly Ile Ser Ala Phe Gly 
            420                 425                 430         


Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe Leu Asn Phe Val Ser Tyr 
        435                 440                 445             


Ala Ala Gly Ala Val Arg Leu Ser Ala Leu Ser Gly His Pro Val Ile 
    450                 455                 460                 


Trp Val Ala Thr His Asp Ser Ile Gly Val Gly Glu Asp Gly Pro Thr 
465                 470                 475                 480 


His Gln Pro Ile Glu Thr Leu Ala His Phe Arg Ser Leu Pro Asn Ile 
                485                 490                 495     


Gln Val Trp Arg Pro Ala Asp Gly Asn Glu Val Ser Ala Ala Tyr Lys 
            500                 505                 510         


Asn Ser Leu Glu Ser Lys His Thr Pro Ser Ile Ile Ala Leu Ser Arg 
        515                 520                 525             


Gln Asn Leu Pro Gln Leu Glu Gly Ser Ser Ile Glu Ser Ala Ser Lys 
    530                 535                 540                 


Gly Gly Tyr Val Leu Gln Asp Val Ala Asn Pro Asp Ile Ile Leu Val 
545                 550                 555                 560 


Ala Thr Gly Ser Glu Val Ser Leu Ser Val Glu Ala Ala Lys Thr Leu 
                565                 570                 575     


Ala Ala Lys Asn Ile Lys Ala Arg Val Val Ser Leu Pro Asp Phe Phe 
            580                 585                 590         


Thr Phe Asp Lys Gln Pro Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp 
        595                 600                 605             


Asn Val Pro Ile Met Ser Val Glu Val Leu Ala Thr Thr Cys Trp Gly 
    610                 615                 620                 


Lys Tyr Ala His Gln Ser Phe Gly Ile Asp Arg Phe Gly Ala Ser Gly 
625                 630                 635                 640 


Lys Ala Pro Glu Val Phe Lys Phe Phe Gly Phe Thr Pro Glu Gly Val 
                645                 650                 655     


Ala Glu Arg Ala Gln Lys Thr Ile Ala Phe Tyr Lys Gly Asp Lys Leu 
            660                 665                 670         


Ile Ser Pro Leu Lys Lys Ala Phe 
        675                 680 


<210>  19
<211>  600
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Leu Cys Ser Val Ile Gln Arg Gln Thr Arg Glu Val Ser Asn Thr 
1               5                   10                  15      


Met Ser Leu Asp Ser Tyr Tyr Leu Gly Phe Asp Leu Ser Thr Gln Gln 
            20                  25                  30          


Leu Lys Cys Leu Ala Ile Asn Gln Asp Leu Lys Ile Val His Ser Glu 
        35                  40                  45              


Thr Val Glu Phe Glu Lys Asp Leu Pro His Tyr Asn Thr Lys Lys Gly 
    50                  55                  60                  


Val Tyr Ile His Gly Asp Ala Ile Glu Cys Pro Val Ala Met Trp Leu 
65                  70                  75                  80  


Glu Ala Leu Asp Leu Val Leu Ser Lys Tyr Arg Glu Ala Lys Phe Pro 
                85                  90                  95      


Leu Asn Lys Val Met Ala Val Ser Gly Ser Cys Gln Gln His Gly Ser 
            100                 105                 110         


Val Tyr Trp Ser Ser Gln Ala Glu Ser Leu Leu Glu Gln Leu Asn Lys 
        115                 120                 125             


Lys Pro Glu Lys Asp Leu Leu His Tyr Val Ser Ser Val Ala Phe Ala 
    130                 135                 140                 


Arg Gln Thr Ala Pro Asn Trp Gln Asp His Ser Thr Ala Lys Gln Cys 
145                 150                 155                 160 


Gln Glu Phe Glu Glu Cys Ile Gly Gly Pro Glu Lys Met Ala Gln Leu 
                165                 170                 175     


Thr Gly Ser Arg Ala His Phe Arg Phe Thr Gly Pro Gln Ile Leu Lys 
            180                 185                 190         


Ile Ala Gln Leu Glu Pro Glu Ala Tyr Glu Lys Thr Lys Thr Ile Ser 
        195                 200                 205             


Leu Val Ser Asn Phe Leu Thr Ser Ile Leu Met Gly His Leu Val Glu 
    210                 215                 220                 


Leu Glu Glu Ala Asp Ala Cys Gly Met Asn Leu Tyr Asp Ile Arg Glu 
225                 230                 235                 240 


Arg Lys Phe Ser Asp Glu Leu Leu His Leu Ile Asp Ser Ser Ser Lys 
                245                 250                 255     


Asp Lys Thr Ile Arg Gln Lys Leu Met Arg Ala Pro Met Lys Asn Leu 
            260                 265                 270         


Ile Ala Gly Thr Ile Cys Lys Tyr Phe Ile Glu Lys Tyr Gly Phe Asn 
        275                 280                 285             


Thr Asn Cys Lys Val Ser Pro Met Thr Gly Asp Asn Leu Ala Thr Ile 
    290                 295                 300                 


Cys Ser Leu Pro Leu Arg Lys Asn Asp Val Leu Val Ser Leu Gly Thr 
305                 310                 315                 320 


Ser Thr Thr Val Leu Leu Val Thr Asp Lys Tyr His Pro Ser Pro Asn 
                325                 330                 335     


Tyr His Leu Phe Ile His Pro Thr Leu Pro Asn His Tyr Met Gly Met 
            340                 345                 350         


Ile Cys Tyr Cys Asn Gly Ser Leu Ala Arg Glu Arg Ile Arg Asp Glu 
        355                 360                 365             


Leu Asn Lys Glu Arg Glu Asn Asn Tyr Glu Lys Thr Asn Asp Trp Ile 
    370                 375                 380                 


Leu Phe Asn Gln Ala Val Leu Asp Asp Ser Glu Ser Ser Glu Asn Glu 
385                 390                 395                 400 


Leu Gly Val Tyr Phe Pro Leu Gly Glu Ile Val Pro Ser Val Lys Ala 
                405                 410                 415     


Ile Asn Lys Arg Val Ile Phe Asn Pro Lys Thr Gly Met Ile Glu Arg 
            420                 425                 430         


Glu Val Ala Lys Phe Lys Asp Lys Arg His Asp Ala Lys Asn Ile Val 
        435                 440                 445             


Glu Ser Gln Ala Leu Ser Cys Arg Val Arg Ile Ser Pro Leu Leu Ser 
    450                 455                 460                 


Asp Ser Asn Ala Ser Ser Gln Gln Arg Leu Asn Glu Asp Thr Ile Val 
465                 470                 475                 480 


Lys Phe Asp Tyr Asp Glu Ser Pro Leu Arg Asp Tyr Leu Asn Lys Arg 
                485                 490                 495     


Pro Glu Arg Thr Phe Phe Val Gly Gly Ala Ser Lys Asn Asp Ala Ile 
            500                 505                 510         


Val Lys Lys Phe Ala Gln Val Ile Gly Ala Thr Lys Gly Asn Phe Arg 
        515                 520                 525             


Leu Glu Thr Pro Asn Ser Cys Ala Leu Gly Gly Cys Tyr Lys Ala Met 
    530                 535                 540                 


Trp Ser Leu Leu Tyr Asp Ser Asn Lys Ile Ala Val Pro Phe Asp Lys 
545                 550                 555                 560 


Phe Leu Asn Asp Asn Phe Pro Trp His Val Met Glu Ser Ile Ser Asp 
                565                 570                 575     


Val Asp Asn Glu Asn Trp Asp Arg Tyr Asn Ser Lys Ile Val Pro Leu 
            580                 585                 590         


Ser Glu Leu Glu Lys Thr Leu Ile 
        595                 600 


<210>  20
<211>  505
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Ser Glu Gly Pro Val Lys Phe Glu Lys Asn Thr Val Ile Ser Val 
1               5                   10                  15      


Phe Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Thr Phe Pro Ala Leu 
            20                  25                  30          


Phe Gly Leu Phe Arg Glu Gly Tyr Leu Asp Pro Ser Thr Lys Ile Phe 
        35                  40                  45              


Gly Tyr Ala Arg Ser Lys Leu Ser Met Glu Glu Asp Leu Lys Ser Arg 
    50                  55                  60                  


Val Leu Pro His Leu Lys Lys Pro His Gly Glu Ala Asp Asp Ser Lys 
65                  70                  75                  80  


Val Glu Gln Phe Phe Lys Met Val Ser Tyr Ile Ser Gly Asn Tyr Asp 
                85                  90                  95      


Thr Asp Glu Gly Phe Asp Glu Leu Arg Thr Gln Ile Glu Lys Phe Glu 
            100                 105                 110         


Lys Ser Ala Asn Val Asp Val Pro His Arg Leu Phe Tyr Leu Ala Leu 
        115                 120                 125             


Pro Pro Ser Val Phe Leu Thr Val Ala Lys Gln Ile Lys Ser Arg Val 
    130                 135                 140                 


Tyr Ala Glu Asn Gly Ile Thr Arg Val Ile Val Glu Lys Pro Phe Gly 
145                 150                 155                 160 


His Asp Leu Ala Ser Ala Arg Glu Leu Gln Lys Asn Leu Gly Pro Leu 
                165                 170                 175     


Phe Lys Glu Glu Glu Leu Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu 
            180                 185                 190         


Leu Val Lys Asn Leu Leu Val Leu Arg Phe Gly Asn Gln Phe Leu Asn 
        195                 200                 205             


Ala Ser Trp Asn Arg Asp Asn Ile Gln Ser Val Gln Ile Ser Phe Lys 
    210                 215                 220                 


Glu Arg Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Ser Ile Gly 
225                 230                 235                 240 


Ile Ile Arg Asp Val Met Gln Asn His Leu Leu Gln Ile Met Thr Leu 
                245                 250                 255     


Leu Thr Met Glu Arg Pro Val Ser Phe Asp Pro Glu Ser Ile Arg Asp 
            260                 265                 270         


Glu Lys Val Lys Val Leu Lys Ala Val Ala Pro Ile Asp Thr Asp Asp 
        275                 280                 285             


Val Leu Leu Gly Gln Tyr Gly Lys Ser Glu Asp Gly Ser Lys Pro Ala 
    290                 295                 300                 


Tyr Val Asp Asp Asp Thr Val Asp Lys Asp Ser Lys Cys Val Thr Phe 
305                 310                 315                 320 


Ala Ala Met Thr Phe Asn Ile Glu Asn Glu Arg Trp Glu Gly Val Pro 
                325                 330                 335     


Ile Met Met Arg Ala Gly Lys Ala Leu Asn Glu Ser Lys Val Glu Ile 
            340                 345                 350         


Arg Leu Gln Tyr Lys Ala Val Ala Ser Gly Val Phe Lys Asp Ile Pro 
        355                 360                 365             


Asn Asn Glu Leu Val Ile Arg Val Gln Pro Asp Ala Ala Val Tyr Leu 
    370                 375                 380                 


Lys Phe Asn Ala Lys Thr Pro Gly Leu Ser Asn Ala Thr Gln Val Thr 
385                 390                 395                 400 


Asp Leu Asn Leu Thr Tyr Ala Ser Arg Tyr Gln Asp Phe Trp Ile Pro 
                405                 410                 415     


Glu Ala Tyr Glu Val Leu Ile Arg Asp Ala Leu Leu Gly Asp His Ser 
            420                 425                 430         


Asn Phe Val Arg Asp Asp Glu Leu Asp Ile Ser Trp Gly Ile Phe Thr 
        435                 440                 445             


Pro Leu Leu Lys His Ile Glu Arg Pro Asp Gly Pro Thr Pro Glu Ile 
    450                 455                 460                 


Tyr Pro Tyr Gly Ser Arg Gly Pro Lys Gly Leu Lys Glu Tyr Met Gln 
465                 470                 475                 480 


Lys His Lys Tyr Val Met Pro Glu Lys His Pro Tyr Ala Trp Pro Val 
                485                 490                 495     


Thr Lys Pro Glu Asp Thr Lys Asp Asn 
            500                 505 


