                         SEQUENCE LISTING

<110>  Weiner, David B.
       Smith, Trevor RF
 
<120>  DNA Antibody Constructs For Use Against Middle East Respiratory 
       Syndrome (MERS) Coronavirus

<130>  206194-0019-00-WO.608062

<150>  US 62/564,177
<151>  2017-09-27

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  5171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, pGX9207 full plasmid sequence

<400>  1
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggattgg acatggagaa ttctgtttct ggtcgccgcc      780

gccactggaa ctcacgctca ggtgcagctg gtgcagtctg gggctgaagt gaagaaacca      840

ggcagctccg tcaaggtgtc atgcaaagcc agcggcggaa cattctctag ttacgcaatc      900

agctgggtgc gacaggctcc aggacaggga ctggagtgga tgggcggcat cattcctatc      960

ttcgggaccg ctaactacgc acagaagttt cagggccgcg tgaccattac agcagataaa     1020

tccacttcta ccgcctatat ggagctgtca agcctgagga gcgaagacac tgcagtctac     1080

tattgcgcca gagtgggata ctgctcctct acctcctgtc acatcggggc cttcgatatt     1140

tggggacagg ggaccacagt caccgtgagt tcagcaagta caaaggggcc ttcagtgttt     1200

cccctggccc ctagctccaa aagtacttca ggagggaccg ccgctctggg atgtctggtg     1260

aaggactatt tccctgagcc agtcaccgtg tcatggaaca gcggggccct gacctccgga     1320

gtccatacat ttccagctgt gctgcagtct agtgggctgt actctctgtc aagcgtggtc     1380

actgtcccct cctctagtct gggcacacag acttatatct gcaacgtgaa tcacaagcct     1440

tccaatacca aagtcgacaa gaaagtggaa ccaaagtctt gtgataaaac ccatacatgc     1500

cctccctgtc cagcacctga gctgctgggc ggaccaagcg tgttcctgtt tccacccaag     1560

cccaaagata cactgatgat tagccggaca cctgaagtca cttgcgtggt cgtggacgtg     1620

agccacgagg accccgaagt caagttcaac tggtacgtgg acggcgtcga ggtgcataat     1680

gctaagacca aaccccgcga ggaacagtac aatagcacat atcgagtcgt gtccgtcctg     1740

actgtgctgc accaggactg gctgaacgga aaggagtata agtgcaaagt gtccaataag     1800

gccctgccag ctcccatcga gaaaacaatt tctaaggcca aaggccagcc acgggaaccc     1860

caggtgtaca ctctgcctcc aagccgcgat gagctgacta agaaccaggt cagcctgacc     1920

tgtctggtga aaggcttcta tccaagtgac atcgctgtgg agtgggaatc taatggacag     1980

cccgaaaaca attacaagac tacccctccc gtgctggact ccgatggctc tttctttctg     2040

tattcaaagc tgacagtgga taaaagccgg tggcagcagg gaaacgtctt tagctgctcc     2100

gtgatgcatg aggccctgca caatcattac acacagaagt ctctgagtct gtcacccgga     2160

aagcgaggac gaaaaaggag aagcggctcc ggagctacta acttctccct gctgaagcag     2220

gcaggagacg tggaggaaaa tcctgggcca atggtcctgc agacccaggt gtttatctct     2280

ctgctgctgt ggattagtgg cgcttacgga gaaacaactc tgactcagag ccccggcacc     2340

ctgtctctga gtcctggaga gcgagctacc ctgagctgta gggcatcaca gagcgtgtca     2400

agctccatcg cctggtatca gcagaagcct ggacaggctc cacgcctgct gatgttcgac     2460

tctagtacaa gagctactgg catccccgat cggttctccg ggtctggcag tggaaccgac     2520

tttacactga acatttcaag cctggagccc gaagatttcg cagtgtacta ttgccagcag     2580

tactcctcta gtccttatac atttgggcag ggcactaagc tggaaatcaa aaggaccgtc     2640

gcagcccctt ccgtgttcat ttttccaccc tctgatgagc agctgaagtc cggcacagcc     2700

tctgtggtgt gcctgctgaa caacttctac ccaagagaag caaaggtcca gtggaaagtg     2760

gacaacgccc tgcagagtgg caattcacag gagagcgtga ccgaacagga ctccaaggat     2820

tctacatata gtctgtcaag cactctgacc ctgagcaaag ctgactacga gaagcacaaa     2880

gtgtatgcat gcgaagtgac ccaccagggg ctgagaagtc cagtgacaaa atcctttaac     2940

agaggggaat gctgataact cgagtctaga gggcccgttt aaacccgctg atcagcctcg     3000

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     3060

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     3120

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     3180

tgggaagaca atagcaggca tgctggggat gcggtgggct ctatggcttc tactgggcgg     3240

ttttatggac agcaagcgaa ccggaattgc cagctggggc gccctctggt aaggttggga     3300

agccctgcaa agtaaactgg atggctttct tgccgccaag gatctgatgg cgcaggggat     3360

caagctctga tcaagagaca ggatgaggat cgtttcgcat gattgaacaa gatggattgc     3420

acgcaggttc tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga     3480

caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt     3540

ttgtcaagac cgacctgtcc ggtgccctga atgaactgca agacgaggca gcgcggctat     3600

cgtggctggc cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg     3660

gaagggactg gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg     3720

ctcctgccga gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc     3780

cggctacctg cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga     3840

tggaagccgg tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag     3900

ccgaactgtt cgccaggctc aaggcgagca tgcccgacgg cgaggatctc gtcgtgaccc     3960

atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg     4020

actgtggccg gctgggtgtg gcggaccgct atcaggacat agcgttggct acccgtgata     4080

ttgctgaaga gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg     4140

ctcccgattc gcagcgcatc gccttctatc gccttcttga cgagttcttc tgaattatta     4200

acgcttacaa tttcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     4260

gcatcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     4320

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatag     4380

cacgtgctaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat     4440

ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa     4500

aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca     4560

aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt     4620

ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg     4680

tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc     4740

ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga     4800

cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc     4860

agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc     4920

gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca     4980

ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg     5040

tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta     5100

tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct     5160

cacatgttct t                                                          5171


<210>  2
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, anti-MERS dMAB

<400>  2

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Val Gly Tyr Cys Ser Ser Thr Ser Cys His Ile 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg 
465                 470                 475                 480 


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                485                 490                 495     


Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile 
            500                 505                 510         


Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Glu Thr Thr Leu Thr 
        515                 520                 525             


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
    530                 535                 540                 


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Ile Ala Trp Tyr Gln 
545                 550                 555                 560 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Met Phe Asp Ser Ser Thr 
                565                 570                 575     


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            580                 585                 590         


Asp Phe Thr Leu Asn Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
        595                 600                 605             


Tyr Tyr Cys Gln Gln Tyr Ser Ser Ser Pro Tyr Thr Phe Gly Gln Gly 
    610                 615                 620                 


Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
625                 630                 635                 640 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
                645                 650                 655     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
            660                 665                 670         


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
        675                 680                 685             


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    690                 695                 700                 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
705                 710                 715                 720 


His Gln Gly Leu Arg Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                725                 730                 735     


Cys 
    


<210>  3
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, anti-MERS dMAB

<400>  3
atggattgga catggagaat tctgtttctg gtcgccgccg ccactggaac tcacgctcag       60

gtgcagctgg tgcagtctgg ggctgaagtg aagaaaccag gcagctccgt caaggtgtca      120

tgcaaagcca gcggcggaac attctctagt tacgcaatca gctgggtgcg acaggctcca      180

ggacagggac tggagtggat gggcggcatc attcctatct tcgggaccgc taactacgca      240

cagaagtttc agggccgcgt gaccattaca gcagataaat ccacttctac cgcctatatg      300

gagctgtcaa gcctgaggag cgaagacact gcagtctact attgcgccag agtgggatac      360

tgctcctcta cctcctgtca catcggggcc ttcgatattt ggggacaggg gaccacagtc      420

accgtgagtt cagcaagtac aaaggggcct tcagtgtttc ccctggcccc tagctccaaa      480

agtacttcag gagggaccgc cgctctggga tgtctggtga aggactattt ccctgagcca      540

gtcaccgtgt catggaacag cggggccctg acctccggag tccatacatt tccagctgtg      600

ctgcagtcta gtgggctgta ctctctgtca agcgtggtca ctgtcccctc ctctagtctg      660

ggcacacaga cttatatctg caacgtgaat cacaagcctt ccaataccaa agtcgacaag      720

aaagtggaac caaagtcttg tgataaaacc catacatgcc ctccctgtcc agcacctgag      780

ctgctgggcg gaccaagcgt gttcctgttt ccacccaagc ccaaagatac actgatgatt      840

agccggacac ctgaagtcac ttgcgtggtc gtggacgtga gccacgagga ccccgaagtc      900

aagttcaact ggtacgtgga cggcgtcgag gtgcataatg ctaagaccaa accccgcgag      960

gaacagtaca atagcacata tcgagtcgtg tccgtcctga ctgtgctgca ccaggactgg     1020

ctgaacggaa aggagtataa gtgcaaagtg tccaataagg ccctgccagc tcccatcgag     1080

aaaacaattt ctaaggccaa aggccagcca cgggaacccc aggtgtacac tctgcctcca     1140

agccgcgatg agctgactaa gaaccaggtc agcctgacct gtctggtgaa aggcttctat     1200

ccaagtgaca tcgctgtgga gtgggaatct aatggacagc ccgaaaacaa ttacaagact     1260

acccctcccg tgctggactc cgatggctct ttctttctgt attcaaagct gacagtggat     1320

aaaagccggt ggcagcaggg aaacgtcttt agctgctccg tgatgcatga ggccctgcac     1380

aatcattaca cacagaagtc tctgagtctg tcacccggaa agcgaggacg aaaaaggaga     1440

agcggctccg gagctactaa cttctccctg ctgaagcagg caggagacgt ggaggaaaat     1500

cctgggccaa tggtcctgca gacccaggtg tttatctctc tgctgctgtg gattagtggc     1560

gcttacggag aaacaactct gactcagagc cccggcaccc tgtctctgag tcctggagag     1620

cgagctaccc tgagctgtag ggcatcacag agcgtgtcaa gctccatcgc ctggtatcag     1680

cagaagcctg gacaggctcc acgcctgctg atgttcgact ctagtacaag agctactggc     1740

atccccgatc ggttctccgg gtctggcagt ggaaccgact ttacactgaa catttcaagc     1800

ctggagcccg aagatttcgc agtgtactat tgccagcagt actcctctag tccttataca     1860

tttgggcagg gcactaagct ggaaatcaaa aggaccgtcg cagccccttc cgtgttcatt     1920

tttccaccct ctgatgagca gctgaagtcc ggcacagcct ctgtggtgtg cctgctgaac     1980

aacttctacc caagagaagc aaaggtccag tggaaagtgg acaacgccct gcagagtggc     2040

aattcacagg agagcgtgac cgaacaggac tccaaggatt ctacatatag tctgtcaagc     2100

actctgaccc tgagcaaagc tgactacgag aagcacaaag tgtatgcatg cgaagtgacc     2160

caccaggggc tgagaagtcc agtgacaaaa tcctttaaca gaggggaatg ctgataa        2217


<210>  4
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, anti-MERS dMAB heavy chain

<400>  4
atggattgga catggagaat tctgtttctg gtcgccgccg ccactggaac tcacgctcag       60

gtgcagctgg tgcagtctgg ggctgaagtg aagaaaccag gcagctccgt caaggtgtca      120

tgcaaagcca gcggcggaac attctctagt tacgcaatca gctgggtgcg acaggctcca      180

ggacagggac tggagtggat gggcggcatc attcctatct tcgggaccgc taactacgca      240

cagaagtttc agggccgcgt gaccattaca gcagataaat ccacttctac cgcctatatg      300

gagctgtcaa gcctgaggag cgaagacact gcagtctact attgcgccag agtgggatac      360

tgctcctcta cctcctgtca catcggggcc ttcgatattt ggggacaggg gaccacagtc      420

accgtgagtt cagcaagtac aaaggggcct tcagtgtttc ccctggcccc tagctccaaa      480

agtacttcag gagggaccgc cgctctggga tgtctggtga aggactattt ccctgagcca      540

gtcaccgtgt catggaacag cggggccctg acctccggag tccatacatt tccagctgtg      600

ctgcagtcta gtgggctgta ctctctgtca agcgtggtca ctgtcccctc ctctagtctg      660

ggcacacaga cttatatctg caacgtgaat cacaagcctt ccaataccaa agtcgacaag      720

aaagtggaac caaagtcttg tgataaaacc catacatgcc ctccctgtcc agcacctgag      780

ctgctgggcg gaccaagcgt gttcctgttt ccacccaagc ccaaagatac actgatgatt      840

agccggacac ctgaagtcac ttgcgtggtc gtggacgtga gccacgagga ccccgaagtc      900

aagttcaact ggtacgtgga cggcgtcgag gtgcataatg ctaagaccaa accccgcgag      960

gaacagtaca atagcacata tcgagtcgtg tccgtcctga ctgtgctgca ccaggactgg     1020

ctgaacggaa aggagtataa gtgcaaagtg tccaataagg ccctgccagc tcccatcgag     1080

aaaacaattt ctaaggccaa aggccagcca cgggaacccc aggtgtacac tctgcctcca     1140

agccgcgatg agctgactaa gaaccaggtc agcctgacct gtctggtgaa aggcttctat     1200

ccaagtgaca tcgctgtgga gtgggaatct aatggacagc ccgaaaacaa ttacaagact     1260

acccctcccg tgctggactc cgatggctct ttctttctgt attcaaagct gacagtggat     1320

aaaagccggt ggcagcaggg aaacgtcttt agctgctccg tgatgcatga ggccctgcac     1380

aatcattaca cacagaagtc tctgagtctg tcacccggaa ag                        1422


<210>  5
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, anti-MERS dMAB heavy chain

<400>  5

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Val Gly Tyr Cys Ser Ser Thr Ser Cys His Ile 
        115                 120                 125             


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  6
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, anti-MERS dMAB light chain

<400>  6
atggtcctgc agacccaggt gtttatctct ctgctgctgt ggattagtgg cgcttacgga       60

gaaacaactc tgactcagag ccccggcacc ctgtctctga gtcctggaga gcgagctacc      120

ctgagctgta gggcatcaca gagcgtgtca agctccatcg cctggtatca gcagaagcct      180

ggacaggctc cacgcctgct gatgttcgac tctagtacaa gagctactgg catccccgat      240

cggttctccg ggtctggcag tggaaccgac tttacactga acatttcaag cctggagccc      300

gaagatttcg cagtgtacta ttgccagcag tactcctcta gtccttatac atttgggcag      360

ggcactaagc tggaaatcaa aaggaccgtc gcagcccctt ccgtgttcat ttttccaccc      420

tctgatgagc agctgaagtc cggcacagcc tctgtggtgt gcctgctgaa caacttctac      480

ccaagagaag caaaggtcca gtggaaagtg gacaacgccc tgcagagtgg caattcacag      540

gagagcgtga ccgaacagga ctccaaggat tctacatata gtctgtcaag cactctgacc      600

ctgagcaaag ctgactacga gaagcacaaa gtgtatgcat gcgaagtgac ccaccagggg      660

ctgagaagtc cagtgacaaa atcctttaac agaggggaat gctgataa                   708


<210>  7
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, anti-MERS dMAB light chain

<400>  7

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Ser Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Met Phe Asp Ser Ser Thr Arg Ala Thr Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


