                         SEQUENCE LISTING

<110>  Cell Design Labs, Inc.
 
<120>  METHODS OF MAKING BISPECIFIC ANTI-CD307E AND ANTI-BCMA CHIMERIC 
       ANTIGEN RECEPTORS AND USES OF THE SAME

<130>  43159-0067WO1

<150>  62/566,025
<151>  2017-09-29

<160>  100   

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  J6M0 Light Chain Variable

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  2
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  J6M0 Heavy Chain Variable

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  J6M0 Light Chain Variable Domain

<400>  3
gatatacaaa tgacccaaag cccaagctct ctgagtgcgt ccgtcgggga cagagtgaca       60

ataacatgta gtgcgtctca ggacatcagt aactacctga actggtacca gcaaaaacca      120

ggtaaggctc ccaagctgct tatttattat acctcaaatc tgcacagcgg cgttccatca      180

cgcttttctg gctctggcag tgggacggac ttcaccctca caatttctag ccttcaacca      240

gaagatttcg ccacttacta ctgtcaacag taccggaagc tgccctggac gttcgggcag      300

ggaacaaaac ttgaaatcaa gcgg                                             324


<210>  4
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  J6M0 Heavy Chain Variable Domain

<400>  4
caagtccagc tggttcaatc cggagctgag gtgaaaaaac caggctcaag cgttaaggtt       60

tcttgcaagg ccagtggggg gactttctcc aactactgga tgcactgggt acggcaggcc      120

cccggtcaag ggcttgaatg gatgggtgcc acgtacagag gacactcaga cacatactat      180

aaccaaaaat tcaaggggcg agttactatt actgcagaca agtcaacttc tacagcctac      240

atggaattgt cctcccttag gtctgaagac acagcagtgt actattgcgc gcggggggcc      300

atatacgacg gatacgacgt gcttgataac tggggccagg gcaccctcgt gactgttagc      360

tcc                                                                    363


<210>  5
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  10A8 Human Light Chain Variable Domain

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Phe Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  6
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  10A8 Human Heavy Chain Variable Domain

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Leu Thr Phe Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Ile Pro Asp Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  10A8 Human Light Chain Variable Domain

<400>  7
gatatccaga tgacccagtc tcctagttcc ttgtccgcat cagtaggaga cagggtcacc       60

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      120

ggaaaagctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtcccttct      180

cgcttctctg gcagtggatc tgggacggat ttcactctca ccatcagcag tctgcagcct      240

gaagactttg caacttatta ctgtcagcaa cattttagta gtcctcggac gttcggtcaa      300

ggtaccaagg tggagatcaa acga                                             324


<210>  8
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  10A8 Human Heavy Chain Variable Domain

<400>  8
gaagtgcagt tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgcgactc       60

tcctgtgcag cctctggatt cactttcagt agctatgccg tgtcttgggt tcgccaggct      120

ccggggaagg gactggagtg ggtcgctacc attagcagtg gtggtagttt gaccttctat      180

ttagacagtg tgaggggtcg attcaccatc tccagagaca atagcaagaa caccctgtac      240

ctgcaaatga atagtctgag ggctgaagac acggccgtgt attactgtgc aaggcccatt      300

ccggattact atgctttgga ctactggggt caaggaacct tagtcaccgt ctcctca         357


<210>  9
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  10A8 Mouse Light Chain Variable Domain

<400>  9

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Arg 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Phe Ser Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  10
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  10A8 Mouse Heavy Chain Variable Domain

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Leu Thr Phe Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Ile Pro Asp Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  10A8 Mouse Light Chain Variable Domain

<400>  11
gatatcgtga tgacccagtc tcataaattc atgtccacat cagtaagaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgagt actgctgtag cctggtatca acagaaacca      120

ggacaatctc ctaaactact gatttattcg gcatcctacc ggtacactgg agtccctgat      180

cgcttcactg gcagtggatc tgggacggat ttcactttca ccatcagcag tgtgcaggct      240

gaagacctgg cagtttatta ctgtcagcaa cattttagta gtcctcggac gttcggtgga      300

ggtaccaagg tggagatcaa acga                                             324


<210>  12
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  10A8 Mouse Heavy Chain Variable Domain

<400>  12
gaagtgcagt tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaaatc       60

tcctgtgcag cctctggatt cactttcagt agctatgccg tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgctacc attagcagtg gtggtagttt gaccttctat      180

ttagacagtg tgaggggtcg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaagac acggccatgt attactgtgc aaggcccatt      300

ccggattact atgctttgga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  13
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  1G7.v85 Light Chain Variable Domain

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Arg Asn Leu 
            20                  25                  30          


Val Val Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  1G7.v85 Heavy Chain Variable Domain

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Arg Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Val 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Asn His Tyr Tyr Gly Ser Ser Asp Tyr Ala Leu Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  1G7.v85 Light Chain Variable Domain

<400>  15
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgca aagcgagcca ggatgtgcgc aacctggtgg tgtggtttca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttatagc ggcagctatc gctatagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagcag cattatagcc cgccgtatac ctttggccag      300

ggcaccaaag tggaaattaa a                                                321


<210>  16
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  1G7.v85 Heavy Chain Variable Domain

<400>  16
gaagtgcagc tggtggaaag cggcccaggc ctggtgaaac cgagcgaaac cctgagcctg       60

acctgcaccg tgagcggctt tagcctgacc cgctttggcg tgcattgggt gcgccagccg      120

ccgggcaaag gcctggaatg gctgggcgtg atttggcgcg gcggcagcac cgattataac      180

gcggcgtttg tgagccgcct gaccattagc aaagataaca gcaaaaacca ggtgagcctg      240

aaactgagca gcgtgaccgc ggcggatacc gcggtgtatt attgcagcaa ccattattat      300

ggcagcagcg attatgcgct ggataactgg ggccagggca ccctggtgac cgtgagcagc      360


<210>  17
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  1G7.v93 Light Chain Variable Domain

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Asn Leu 
            20                  25                  30          


Val Val Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  1G7.v93 Heavy Chain Variable Domain

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Thr Thr Arg Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Val 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Asn His Tyr Tyr Gly Ser Pro Asp Tyr Ala Leu Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  19
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  1G7.v93 Light Chain Variable Domain

<400>  19
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgca aagcgagcca ggatgtgagc aacctggtgg tgtggtttca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttatagc ggcagctatc gctatagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagcag cattatagcc cgccgtatac ctttggccag      300

ggcaccaaag tggaaattaa a                                                321


<210>  20
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  1G7.v93 Heavy Chain Variable Domain

<400>  20
gaagtgcagc tggtggaaag cggcccgggc ctggtgaaac cgagcgaaac cctgagcctg       60

acctgcaccg tgagcggctt tagcacgacc cgctttggcg tgcattgggt gcgccagccg      120

ccgggcaaag gcctggaatg gctgggcgtg atttggcgcg gcggcagcac cgattataac      180

gcggcgtttg tgagccgcct gaccattagc aaagataaca gcaaaaacca ggtgagcctg      240

aaactgagca gcgtgaccgc ggcggatacc gcggtgtatt attgcagcaa ccattattat      300

ggcagccccg attatgcgct ggataactgg ggccagggca ccctggtgac cgtgagcagc      360


<210>  21
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  21

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210>  22
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Ser 
1               5                   10                  15      


Gly Ser Gly 
            


<210>  23
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  24
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Whitlow linker

<400>  24
ggcagcacca gcggcagcgg caaaccgggc agcggcgaag gcagcaccaa aggc             54


<210>  25
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  (G4S)5 linker

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  26
<211>  75
<212>  DNA
<213>  Artificial

<220>
<223>  (G4S)5 linker

<400>  26
ggcggtggtg gttctggagg cggtggcagc ggtggaggtg gctcaggagg aggaggtagc       60

ggcggcggag ggagt                                                        75


<210>  27
<211>  233
<212>  PRT
<213>  Artificial

<220>
<223>  Human IgG1 CH2-CH3 domains

<400>  27

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Trp Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210>  28
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  Human CD8 Sequence

<400>  28

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  29
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Human IgG1 Hinge Sequence

<400>  29

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  30
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  31
<211>  994
<212>  DNA
<213>  Homo sapiens

<400>  31
aagactcaaa cttagaaact tgaattagat gtggtattca aatccttagc tgccgcgaag       60

acacagacag cccccgtaag aacccacgaa gcaggcgaag ttcattgttc tcaacattct      120

agctgctctt gctgcatttg ctctggaatt cttgtagaga tattacttgt ccttccaggc      180

tgttctttct gtagctccct tgttttcttt ttgtgatcat gttgcagatg gctgggcagt      240

gctcccaaaa tgaatatttt gacagtttgt tgcatgcttg cataccttgt caacttcgat      300

gttcttctaa tactcctcct ctaacatgtc agcgttattg taatgcaagt gtgaccaatt      360

cagtgaaagg aacgaatgcg attctctgga cctgtttggg actgagctta ataatttctt      420

tggcagtttt cgtgctaatg tttttgctaa ggaagataaa ctctgaacca ttaaaggacg      480

agtttaaaaa cacaggatca ggtctcctgg gcatggctaa cattgacctg gaaaagagca      540

ggactggtga tgaaattatt cttccgagag gcctcgagta cacggtggaa gaatgcacct      600

gtgaagactg catcaagagc aaaccgaagg tcgactctga ccattgcttt ccactcccag      660

ctatggagga aggcgcaacc attcttgtca ccacgaaaac gaatgactat tgcaagagcc      720

tgccagctgc tttgagtgct acggagatag agaaatcaat ttctgctagg taattaacca      780

tttcgactcg agcagtgcca ctttaaaaat cttttgtcag aatagatgat gtgtcagatc      840

tctttaggat gactgtattt ttcagttgcc gatacagctt tttgtcctct aactgtggaa      900

actctttatg ttagatatat ttctctaggt tactgttggg agcttaatgg tagaaacttc      960

cttggtttca tgattaaact cttttttttc ctga                                  994


<210>  32
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Arg Ser Gly Leu Leu 
        35                  40                  45              


Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu Ile 
    50                  55                  60                  


Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
65                  70                  75                  80  


Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro 
                85                  90                  95      


Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
            100                 105                 110         


Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu Ile 
        115                 120                 125             


Glu Lys Ser Ile Ser Ala Arg 
    130                 135 


<210>  33
<211>  668
<212>  DNA
<213>  Homo sapiens

<400>  33
gttctcaaca ttctagctgc tcttgctgca tttgctctgg aattcttgta gagatattac       60

ttgtccttcc aggctgttct ttctgtagct cccttgtttt ctttttgtga tcatgttgca      120

gatggctggg cagtgctccc aaaatgaata ttttgacagt ttgttgcatg cttgcatacc      180

ttgtcaactt cgatgttctt ctaatactcc tcctctaaca tgtcagcgtt attgtaatgc      240

aagatcaggt ctcctgggca tggctaacat tgacctggaa aagagcagga ctggtgatga      300

aattattctt ccgagaggcc tcgagtacac ggtggaagaa tgcacctgtg aagactgcat      360

caagagcaaa ccgaaggtcg actctgacca ttgctttcca ctcccagcta tggaggaagg      420

cgcaaccatt cttgtcacca cgaaaacgaa tgactattgc aagagcctgc cagctgcttt      480

gagtgctacg gagatagaga aatcaatttc tgctaggtaa ttaaccattt cgactcgagc      540

agtgccactt taaaaatctt ttgtcagaat agatgatgtg tcagatctct ttaggatgac      600

tgtatttttc agttgccgat acagcttttt gtcctctaac tgtggaaact ctttatgtta      660

gatatatt                                                               668


<210>  34
<211>  977
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg Pro 
            740                 745                 750         


Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp Leu 
        755                 760                 765             


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr 
    770                 775                 780                 


Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser 
785                 790                 795                 800 


Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
                805                 810                 815     


Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr 
            820                 825                 830         


Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe 
        835                 840                 845             


Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala 
    850                 855                 860                 


Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys 
865                 870                 875                 880 


Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu 
                885                 890                 895     


Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr 
            900                 905                 910         


Thr Asn Ala Asn Pro Arg Gly Glu Asn Val Val Tyr Ser Glu Val Arg 
        915                 920                 925             


Ile Ile Gln Glu Lys Lys Lys His Ala Val Ala Ser Asp Pro Arg His 
    930                 935                 940                 


Leu Arg Asn Lys Gly Ser Pro Ile Ile Tyr Ser Glu Val Lys Val Ala 
945                 950                 955                 960 


Ser Thr Pro Val Ser Gly Ser Leu Phe Leu Ala Ser Ser Ala Pro His 
                965                 970                 975     


Arg 
    


<210>  35
<211>  5395
<212>  DNA
<213>  Homo sapiens

<400>  35
aattcactaa tgcattctgc tctttttgag agcacagctt ctcagatgtg ctccttggag       60

ctggtgtgca gtgtcctgac tgtaagatca agtccaaacc tgttttggaa ttgaggaaac      120

ttctcttttg atctcagccc ttggtggtcc aggtcttcat gctgctgtgg gtgatattac      180

tggtcctggc tcctgtcagt ggacagtttg caaggacacc caggcccatt attttcctcc      240

agcctccatg gaccacagtc ttccaaggag agagagtgac cctcacttgc aagggatttc      300

gcttctactc accacagaaa acaaaatggt accatcggta ccttgggaaa gaaatactaa      360

gagaaacccc agacaatatc cttgaggttc aggaatctgg agagtacaga tgccaggccc      420

agggctcccc tctcagtagc cctgtgcact tggatttttc ttcagcttcg ctgatcctgc      480

aagctccact ttctgtgttt gaaggagact ctgtggttct gaggtgccgg gcaaaggcgg      540

aagtaacact gaataatact atttacaaga atgataatgt cctggcattc cttaataaaa      600

gaactgactt ccatattcct catgcatgtc tcaaggacaa tggtgcatat cgctgtactg      660

gatataagga aagttgttgc cctgtttctt ccaatacagt caaaatccaa gtccaagagc      720

catttacacg tccagtgctg agagccagct ccttccagcc catcagcggg aacccagtga      780

ccctgacctg tgagacccag ctctctctag agaggtcaga tgtcccgctc cggttccgct      840

tcttcagaga tgaccagacc ctgggattag gctggagtct ctccccgaat ttccagatta      900

ctgccatgtg gagtaaagat tcagggttct actggtgtaa ggcagcaaca atgccttaca      960

gcgtcatatc tgacagcccg agatcctgga tacaggtgca gatccctgca tctcatcctg     1020

tcctcactct cagccctgaa aaggctctga attttgaggg aaccaaggtg acacttcact     1080

gtgaaaccca ggaagattct ctgcgcactt tgtacaggtt ttatcatgag ggtgtccccc     1140

tgaggcacaa gtcagtccgc tgtgaaaggg gagcatccat cagcttctca ctgactacag     1200

agaattcagg gaactactac tgcacagctg acaatggcct tggcgccaag cccagtaagg     1260

ctgtgagcct ctcagtcact gttcccgtgt ctcatcctgt cctcaacctc agctctcctg     1320

aggacctgat ttttgaggga gccaaggtga cacttcactg tgaagcccag agaggttcac     1380

tccccatcct gtaccagttt catcatgagg gtgctgccct ggagcgtagg tcggccaact     1440

ctgcaggagg agtggccatc agcttctctc tgactgcaga gcattcaggg aactactact     1500

gcacagctga caatggcttt ggcccccagc gcagtaaggc ggtgagcctc tccgtcactg     1560

tccctgtgtc tcatcctgtc ctcaccctca gctctgctga ggccctgact tttgaaggag     1620

ccactgtgac acttcactgt gaagtccaga gaggttcccc acaaatccta taccagtttt     1680

atcatgagga catgcccctg tggagcagct caacaccctc tgtgggaaga gtgtccttca     1740

gcttctctct gactgaagga cattcaggga attactactg cacagctgac aatggctttg     1800

gtccccagcg cagtgaagtg gtgagccttt ttgtcactgt tccagtgtct cgccccatcc     1860

tcaccctcag ggttcccagg gcccaggctg tggtggggga cctgctggag cttcactgtg     1920

aggccccgag aggctctccc ccaatcctgt actggtttta tcatgaggat gtcaccctgg     1980

ggagcagctc agccccctct ggaggagaag cttctttcaa cctctctctg actgcagaac     2040

attctggaaa ctactcatgt gaggccaaca atggcctagt ggcccagcac agtgacacaa     2100

tatcactcag tgttatagtt ccagtatctc gtcccatcct caccttcagg gctcccaggg     2160

cccaggctgt ggtgggggac ctgctggagc ttcactgtga ggccctgaga ggctcctccc     2220

caatcctgta ctggttttat catgaagatg tcaccctggg taagatctca gccccctctg     2280

gaggaggggc ctccttcaac ctctctctga ctacagaaca ttctggaatc tactcctgtg     2340

aggcagacaa tggtctggag gcccagcgca gtgagatggt gacactgaaa gttgcagttc     2400

cggtgtctcg cccggtcctc accctcaggg ctcccgggac ccatgctgcg gtgggggacc     2460

tgctggagct tcactgtgag gccctgagag gctctcccct gatcctgtac cggttttttc     2520

atgaggatgt caccctagga aataggtcgt ccccctctgg aggagcgtcc ttaaacctct     2580

ctctgactgc agagcactct ggaaactact cctgtgaggc cgacaatggc ctcggggccc     2640

agcgcagtga gacagtgaca ctttatatca cagggctgac cgcgaacaga agtggccctt     2700

ttgccacagg agtcgccggg ggcctgctca gcatagcagg ccttgctgcg ggggcactgc     2760

tgctctactg ctggctctcg agaaaagcag ggagaaagcc tgcctctgac cccgccagga     2820

gcccttcaga ctcggactcc caagagccca cctatcacaa tgtaccagcc tgggaagagc     2880

tgcaaccagt gtacactaat gcaaatccta gaggagaaaa tgtggtttac tcagaagtac     2940

ggatcatcca agagaaaaag aaacatgcag tggcctctga ccccaggcat ctcaggaaca     3000

agggttcccc tatcatctac tctgaagtta aggtggcgtc aaccccggtt tccggatccc     3060

tgttcttggc ttcctcagct cctcacagat gagtccacac gtctctccaa ctgctgtttc     3120

agcctctgca ccccaaagtt ccccttgggg gagaagcagc attgaagtgg gaagatttag     3180

gctgccccag accatatcta ctggcctttg tttcacatgt cctcattctc agtctgacca     3240

gaatgcaggg ccctgctgga ctgtcacctg tttcccagtt aaagccctga ctggcaggtt     3300

ttttaatcca gtggcaaggt gctcccactc cagggcccag cacatctcct ggattcctta     3360

gtgggcttca gctgtggttg ctgttctgag tactgctctc atcacacccc cacagagggg     3420

gtcttaccac acaaagggag agtgggcctt caggagatgc cgggctggcc taacagctca     3480

ggtgctccta aactccgaca cagagttcct gctttgggtg gatgcatttc tcaattgtca     3540

tcagcctggt ggggctactg cagtgtgctg ccaaatggga cagcacacag cctgtgcaca     3600

tgggacatgt gatgggtctc cccacggggg ctgcatttca cactcctcca cctgtctcaa     3660

actctaaggt cggcacttga caccaaggta acttctctcc tgctcatgtg tcagtgtcta     3720

cctgcccaag taagtggctt tcatacacca agtcccaagt tcttcccatc ctaacagaag     3780

taacccagca agtcaaggcc aggaggacca ggggtgcaga cagaacacat actggaacac     3840

aggaggtgct caattactat ttgactgact gactgaatga atgaatgaat gaggaagaaa     3900

actgtgggta atcaaactgg cataaaatcc agtgcactcc ctaggaaatc cgggaggtat     3960

tctggcttcc ctaagaaaca atggaagaga aggagcttgg atgaggaaac tgttcagcaa     4020

gaggaagggc ttctcacact ttcatgtgct tgtggatcac ctgaggatcc tgtgaaaata     4080

cagatactga ttcagtgggt ctgcgtagag cctgagactg ccattctaac atgttcccag     4140

gggatgctga tgctgctggc cctgggactg cactgcatgc atgtgaagcc ctataggtct     4200

cagcagaggc ccatggagag ggaatgtgtg gctctggctg cccagggccc aactcggttc     4260

acacggatcg tgctgctccc tggccagcct ttggccacag caccaccagc tgctgttgct     4320

gagagagctt cttctctgtg acatgttggc tttcatcagc caccctggga agcggaaagt     4380

agctgccact atctttgttt ccccacctca ggcctcacac tttcccatga aaagggtgaa     4440

tgtatataac ctgagccctc tccattcaga gttgttctcc catctctgag caatgggatg     4500

ttctgttccg cttttatgat atccatcaca tcttatcttg atctttgctc ccagtggatt     4560

gtacagtgat gacttttaag ccccacggcc ctgaaataaa atccttccaa gggcattgga     4620

agctcactcc acctgaacca tggcttttca tgcttccaag tgtcagggcc ttgcccagat     4680

agacagggct ggctctgctg ccccaacctt tcaaggagga aaccagacac ctgagacagg     4740

agcctgtatg cagcccagtg cagccttgca gaggacaagg ctggaggcat ttgtcatcac     4800

tacagatatg caactaaaat agacgtggag caagagaaat gcattcccac cgaggccgct     4860

tttttaggcc tagttgaaag tcaagaagga cagcagcaag cataggctca ggattaaaga     4920

aaaaaatctg ctcacagtct gttctggagg tcacatcacc aacaaagctc acgccctatg     4980

cagttctgag aaggtggagg caccaggctc aaaagaggaa atttagaatt tctcattggg     5040

agagtaaggt acccccatcc cagaatgata actgcacagt ggcagaacaa actccaccct     5100

aatgtgggtg gaccccgtcc agtctgttga aggcctgaat gtaacaaaag ggcttattct     5160

tcctcaagta agggggaact cctgctttgg gctgggacat aagtttttct gctttcagac     5220

gcaaactgaa aaatggctct tcttgggtct tgagcttgct ggcatatgga ctgaaagaaa     5280

ctatgctatt ggatctcctg gatctccagc ttgctgactg cagatcttga gatatgtcag     5340

cctctacagt cacaagagct aattcattct aataaaccaa tctttctgta aaaaa          5395


<210>  36
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Leu Trp Val Ile Leu Leu Val Leu Ala Pro Val Ser Gly Gln 
1               5                   10                  15      


Phe Ala Arg Thr Pro Arg Pro Ile Ile Phe Leu Gln Pro Pro Trp Thr 
            20                  25                  30          


Thr Val Phe Gln Gly Glu Arg Val Thr Leu Thr Cys Lys Gly Phe Arg 
        35                  40                  45              


Phe Tyr Ser Pro Gln Lys Thr Lys Trp Tyr His Arg Tyr Leu Gly Lys 
    50                  55                  60                  


Glu Ile Leu Arg Glu Thr Pro Asp Asn Ile Leu Glu Val Gln Glu Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Ala Gln Gly Ser Pro Leu Ser Ser Pro Val 
                85                  90                  95      


His Leu Asp Phe Ser Ser Ala Ser Leu Ile Leu Gln Ala Pro Leu Ser 
            100                 105                 110         


Val Phe Glu Gly Asp Ser Val Val Leu Arg Cys Arg Ala Lys Ala Glu 
        115                 120                 125             


Val Thr Leu Asn Asn Thr Ile Tyr Lys Asn Asp Asn Val Leu Ala Phe 
    130                 135                 140                 


Leu Asn Lys Arg Thr Asp Phe His Ile Pro His Ala Cys Leu Lys Asp 
145                 150                 155                 160 


Asn Gly Ala Tyr Arg Cys Thr Gly Tyr Lys Glu Ser Cys Cys Pro Val 
                165                 170                 175     


Ser Ser Asn Thr Val Lys Ile Gln Val Gln Glu Pro Phe Thr Arg Pro 
            180                 185                 190         


Val Leu Arg Ala Ser Ser Phe Gln Pro Ile Ser Gly Asn Pro Val Thr 
        195                 200                 205             


Leu Thr Cys Glu Thr Gln Leu Ser Leu Glu Arg Ser Asp Val Pro Leu 
    210                 215                 220                 


Arg Phe Arg Phe Phe Arg Asp Asp Gln Thr Leu Gly Leu Gly Trp Ser 
225                 230                 235                 240 


Leu Ser Pro Asn Phe Gln Ile Thr Ala Met Trp Ser Lys Asp Ser Gly 
                245                 250                 255     


Phe Tyr Trp Cys Lys Ala Ala Thr Met Pro Tyr Ser Val Ile Ser Asp 
            260                 265                 270         


Ser Pro Arg Ser Trp Ile Gln Val Gln Ile Pro Ala Ser His Pro Val 
        275                 280                 285             


Leu Thr Leu Ser Pro Glu Lys Ala Leu Asn Phe Glu Gly Thr Lys Val 
    290                 295                 300                 


Thr Leu His Cys Glu Thr Gln Glu Asp Ser Leu Arg Thr Leu Tyr Arg 
305                 310                 315                 320 


Phe Tyr His Glu Gly Val Pro Leu Arg His Lys Ser Val Arg Cys Glu 
                325                 330                 335     


Arg Gly Ala Ser Ile Ser Phe Ser Leu Thr Thr Glu Asn Ser Gly Asn 
            340                 345                 350         


Tyr Tyr Cys Thr Ala Asp Asn Gly Leu Gly Ala Lys Pro Ser Lys Ala 
        355                 360                 365             


Val Ser Leu Ser Val Thr Val Pro Val Ser His Pro Val Leu Asn Leu 
    370                 375                 380                 


Ser Ser Pro Glu Asp Leu Ile Phe Glu Gly Ala Lys Val Thr Leu His 
385                 390                 395                 400 


Cys Glu Ala Gln Arg Gly Ser Leu Pro Ile Leu Tyr Gln Phe His His 
                405                 410                 415     


Glu Gly Ala Ala Leu Glu Arg Arg Ser Ala Asn Ser Ala Gly Gly Val 
            420                 425                 430         


Ala Ile Ser Phe Ser Leu Thr Ala Glu His Ser Gly Asn Tyr Tyr Cys 
        435                 440                 445             


Thr Ala Asp Asn Gly Phe Gly Pro Gln Arg Ser Lys Ala Val Ser Leu 
    450                 455                 460                 


Ser Val Thr Val Pro Val Ser His Pro Val Leu Thr Leu Ser Ser Ala 
465                 470                 475                 480 


Glu Ala Leu Thr Phe Glu Gly Ala Thr Val Thr Leu His Cys Glu Val 
                485                 490                 495     


Gln Arg Gly Ser Pro Gln Ile Leu Tyr Gln Phe Tyr His Glu Asp Met 
            500                 505                 510         


Pro Leu Trp Ser Ser Ser Thr Pro Ser Val Gly Arg Val Ser Phe Ser 
        515                 520                 525             


Phe Ser Leu Thr Glu Gly His Ser Gly Asn Tyr Tyr Cys Thr Ala Asp 
    530                 535                 540                 


Asn Gly Phe Gly Pro Gln Arg Ser Glu Val Val Ser Leu Phe Val Thr 
545                 550                 555                 560 


Val Pro Val Ser Arg Pro Ile Leu Thr Leu Arg Val Pro Arg Ala Gln 
                565                 570                 575     


Ala Val Val Gly Asp Leu Leu Glu Leu His Cys Glu Ala Pro Arg Gly 
            580                 585                 590         


Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly 
        595                 600                 605             


Ser Ser Ser Ala Pro Ser Gly Gly Glu Ala Ser Phe Asn Leu Ser Leu 
    610                 615                 620                 


Thr Ala Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu 
625                 630                 635                 640 


Val Ala Gln His Ser Asp Thr Ile Ser Leu Ser Val Ile Val Pro Val 
                645                 650                 655     


Ser Arg Pro Ile Leu Thr Phe Arg Ala Pro Arg Ala Gln Ala Val Val 
            660                 665                 670         


Gly Asp Leu Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Ser Pro 
        675                 680                 685             


Ile Leu Tyr Trp Phe Tyr His Glu Asp Val Thr Leu Gly Lys Ile Ser 
    690                 695                 700                 


Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Thr Glu 
705                 710                 715                 720 


His Ser Gly Ile Tyr Ser Cys Glu Ala Asp Asn Gly Leu Glu Ala Gln 
                725                 730                 735     


Arg Ser Glu Met Val Thr Leu Lys Val Ala Val Pro Val Ser Arg Pro 
            740                 745                 750         


Val Leu Thr Leu Arg Ala Pro Gly Thr His Ala Ala Val Gly Asp Leu 
        755                 760                 765             


Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Leu Ile Leu Tyr 
    770                 775                 780                 


Arg Phe Phe His Glu Asp Val Thr Leu Gly Asn Arg Ser Ser Pro Ser 
785                 790                 795                 800 


Gly Gly Ala Ser Leu Asn Leu Ser Leu Thr Ala Glu His Ser Gly Asn 
                805                 810                 815     


Tyr Ser Cys Glu Ala Asp Asn Gly Leu Gly Ala Gln Arg Ser Glu Thr 
            820                 825                 830         


Val Thr Leu Tyr Ile Thr Gly Leu Thr Ala Asn Arg Ser Gly Pro Phe 
        835                 840                 845             


Ala Thr Gly Val Ala Gly Gly Leu Leu Ser Ile Ala Gly Leu Ala Ala 
    850                 855                 860                 


Gly Ala Leu Leu Leu Tyr Cys Trp Leu Ser Arg Lys Ala Gly Arg Lys 
865                 870                 875                 880 


Pro Ala Ser Asp Pro Ala Arg Ser Pro Ser Asp Ser Asp Ser Gln Glu 
                885                 890                 895     


Pro Thr Tyr His Asn Val Pro Ala Trp Glu Glu Leu Gln Pro Val Tyr 
            900                 905                 910         


Thr Asn Glu Glu Lys Met Trp Phe Thr Gln Lys Tyr Gly Ser Ser Lys 
        915                 920                 925             


Arg Lys Arg Asn Met Gln Trp Pro Leu Thr Pro Gly Ile Ser Gly Thr 
    930                 935                 940                 


Arg Val Pro Leu Ser Ser Thr Leu Lys Leu Arg Trp Arg Gln Pro Arg 
945                 950                 955                 960 


Phe Pro Asp Pro Cys Ser Trp Leu Pro Gln Leu Leu Thr Asp Glu Ser 
                965                 970                 975     


Thr Arg Leu Ser Asn Cys Cys Phe Ser Leu Cys Thr Pro Lys Phe Pro 
            980                 985                 990         


Leu Gly Glu Lys Gln His 
        995             


<210>  37
<211>  5380
<212>  DNA
<213>  Homo sapiens

<400>  37
aattcactaa tgcattctgc tctttttgag agcacagctt ctcagatgtg ctccttggag       60

ctggtgtgca gtgtcctgac tgtaagatca agtccaaacc tgttttggaa ttgaggaaac      120

ttctcttttg atctcagccc ttggtggtcc aggtcttcat gctgctgtgg gtgatattac      180

tggtcctggc tcctgtcagt ggacagtttg caaggacacc caggcccatt attttcctcc      240

agcctccatg gaccacagtc ttccaaggag agagagtgac cctcacttgc aagggatttc      300

gcttctactc accacagaaa acaaaatggt accatcggta ccttgggaaa gaaatactaa      360

gagaaacccc agacaatatc cttgaggttc aggaatctgg agagtacaga tgccaggccc      420

agggctcccc tctcagtagc cctgtgcact tggatttttc ttcagcttcg ctgatcctgc      480

aagctccact ttctgtgttt gaaggagact ctgtggttct gaggtgccgg gcaaaggcgg      540

aagtaacact gaataatact atttacaaga atgataatgt cctggcattc cttaataaaa      600

gaactgactt ccatattcct catgcatgtc tcaaggacaa tggtgcatat cgctgtactg      660

gatataagga aagttgttgc cctgtttctt ccaatacagt caaaatccaa gtccaagagc      720

catttacacg tccagtgctg agagccagct ccttccagcc catcagcggg aacccagtga      780

ccctgacctg tgagacccag ctctctctag agaggtcaga tgtcccgctc cggttccgct      840

tcttcagaga tgaccagacc ctgggattag gctggagtct ctccccgaat ttccagatta      900

ctgccatgtg gagtaaagat tcagggttct actggtgtaa ggcagcaaca atgccttaca      960

gcgtcatatc tgacagcccg agatcctgga tacaggtgca gatccctgca tctcatcctg     1020

tcctcactct cagccctgaa aaggctctga attttgaggg aaccaaggtg acacttcact     1080

gtgaaaccca ggaagattct ctgcgcactt tgtacaggtt ttatcatgag ggtgtccccc     1140

tgaggcacaa gtcagtccgc tgtgaaaggg gagcatccat cagcttctca ctgactacag     1200

agaattcagg gaactactac tgcacagctg acaatggcct tggcgccaag cccagtaagg     1260

ctgtgagcct ctcagtcact gttcccgtgt ctcatcctgt cctcaacctc agctctcctg     1320

aggacctgat ttttgaggga gccaaggtga cacttcactg tgaagcccag agaggttcac     1380

tccccatcct gtaccagttt catcatgagg gtgctgccct ggagcgtagg tcggccaact     1440

ctgcaggagg agtggccatc agcttctctc tgactgcaga gcattcaggg aactactact     1500

gcacagctga caatggcttt ggcccccagc gcagtaaggc ggtgagcctc tccgtcactg     1560

tccctgtgtc tcatcctgtc ctcaccctca gctctgctga ggccctgact tttgaaggag     1620

ccactgtgac acttcactgt gaagtccaga gaggttcccc acaaatccta taccagtttt     1680

atcatgagga catgcccctg tggagcagct caacaccctc tgtgggaaga gtgtccttca     1740

gcttctctct gactgaagga cattcaggga attactactg cacagctgac aatggctttg     1800

gtccccagcg cagtgaagtg gtgagccttt ttgtcactgt tccagtgtct cgccccatcc     1860

tcaccctcag ggttcccagg gcccaggctg tggtggggga cctgctggag cttcactgtg     1920

aggccccgag aggctctccc ccaatcctgt actggtttta tcatgaggat gtcaccctgg     1980

ggagcagctc agccccctct ggaggagaag cttctttcaa cctctctctg actgcagaac     2040

attctggaaa ctactcatgt gaggccaaca atggcctagt ggcccagcac agtgacacaa     2100

tatcactcag tgttatagtt ccagtatctc gtcccatcct caccttcagg gctcccaggg     2160

cccaggctgt ggtgggggac ctgctggagc ttcactgtga ggccctgaga ggctcctccc     2220

caatcctgta ctggttttat catgaagatg tcaccctggg taagatctca gccccctctg     2280

gaggaggggc ctccttcaac ctctctctga ctacagaaca ttctggaatc tactcctgtg     2340

aggcagacaa tggtctggag gcccagcgca gtgagatggt gacactgaaa gttgcagttc     2400

cggtgtctcg cccggtcctc accctcaggg ctcccgggac ccatgctgcg gtgggggacc     2460

tgctggagct tcactgtgag gccctgagag gctctcccct gatcctgtac cggttttttc     2520

atgaggatgt caccctagga aataggtcgt ccccctctgg aggagcgtcc ttaaacctct     2580

ctctgactgc agagcactct ggaaactact cctgtgaggc cgacaatggc ctcggggccc     2640

agcgcagtga gacagtgaca ctttatatca cagggctgac cgcgaacaga agtggccctt     2700

ttgccacagg agtcgccggg ggcctgctca gcatagcagg ccttgctgcg ggggcactgc     2760

tgctctactg ctggctctcg agaaaagcag ggagaaagcc tgcctctgac cccgccagga     2820

gcccttcaga ctcggactcc caagagccca cctatcacaa tgtaccagcc tgggaagagc     2880

tgcaaccagt gtacactaat gaggagaaaa tgtggtttac tcagaagtac ggatcatcca     2940

agagaaaaag aaacatgcag tggcctctga ccccaggcat ctcaggaaca agggttcccc     3000

tatcatctac tctgaagtta aggtggcgtc aaccccggtt tccggatccc tgttcttggc     3060

ttcctcagct cctcacagat gagtccacac gtctctccaa ctgctgtttc agcctctgca     3120

ccccaaagtt ccccttgggg gagaagcagc attgaagtgg gaagatttag gctgccccag     3180

accatatcta ctggcctttg tttcacatgt cctcattctc agtctgacca gaatgcaggg     3240

ccctgctgga ctgtcacctg tttcccagtt aaagccctga ctggcaggtt ttttaatcca     3300

gtggcaaggt gctcccactc cagggcccag cacatctcct ggattcctta gtgggcttca     3360

gctgtggttg ctgttctgag tactgctctc atcacacccc cacagagggg gtcttaccac     3420

acaaagggag agtgggcctt caggagatgc cgggctggcc taacagctca ggtgctccta     3480

aactccgaca cagagttcct gctttgggtg gatgcatttc tcaattgtca tcagcctggt     3540

ggggctactg cagtgtgctg ccaaatggga cagcacacag cctgtgcaca tgggacatgt     3600

gatgggtctc cccacggggg ctgcatttca cactcctcca cctgtctcaa actctaaggt     3660

cggcacttga caccaaggta acttctctcc tgctcatgtg tcagtgtcta cctgcccaag     3720

taagtggctt tcatacacca agtcccaagt tcttcccatc ctaacagaag taacccagca     3780

agtcaaggcc aggaggacca ggggtgcaga cagaacacat actggaacac aggaggtgct     3840

caattactat ttgactgact gactgaatga atgaatgaat gaggaagaaa actgtgggta     3900

atcaaactgg cataaaatcc agtgcactcc ctaggaaatc cgggaggtat tctggcttcc     3960

ctaagaaaca atggaagaga aggagcttgg atgaggaaac tgttcagcaa gaggaagggc     4020

ttctcacact ttcatgtgct tgtggatcac ctgaggatcc tgtgaaaata cagatactga     4080

ttcagtgggt ctgcgtagag cctgagactg ccattctaac atgttcccag gggatgctga     4140

tgctgctggc cctgggactg cactgcatgc atgtgaagcc ctataggtct cagcagaggc     4200

ccatggagag ggaatgtgtg gctctggctg cccagggccc aactcggttc acacggatcg     4260

tgctgctccc tggccagcct ttggccacag caccaccagc tgctgttgct gagagagctt     4320

cttctctgtg acatgttggc tttcatcagc caccctggga agcggaaagt agctgccact     4380

atctttgttt ccccacctca ggcctcacac tttcccatga aaagggtgaa tgtatataac     4440

ctgagccctc tccattcaga gttgttctcc catctctgag caatgggatg ttctgttccg     4500

cttttatgat atccatcaca tcttatcttg atctttgctc ccagtggatt gtacagtgat     4560

gacttttaag ccccacggcc ctgaaataaa atccttccaa gggcattgga agctcactcc     4620

acctgaacca tggcttttca tgcttccaag tgtcagggcc ttgcccagat agacagggct     4680

ggctctgctg ccccaacctt tcaaggagga aaccagacac ctgagacagg agcctgtatg     4740

cagcccagtg cagccttgca gaggacaagg ctggaggcat ttgtcatcac tacagatatg     4800

caactaaaat agacgtggag caagagaaat gcattcccac cgaggccgct tttttaggcc     4860

tagttgaaag tcaagaagga cagcagcaag cataggctca ggattaaaga aaaaaatctg     4920

ctcacagtct gttctggagg tcacatcacc aacaaagctc acgccctatg cagttctgag     4980

aaggtggagg caccaggctc aaaagaggaa atttagaatt tctcattggg agagtaaggt     5040

acccccatcc cagaatgata actgcacagt ggcagaacaa actccaccct aatgtgggtg     5100

gaccccgtcc agtctgttga aggcctgaat gtaacaaaag ggcttattct tcctcaagta     5160

agggggaact cctgctttgg gctgggacat aagtttttct gctttcagac gcaaactgaa     5220

aaatggctct tcttgggtct tgagcttgct ggcatatgga ctgaaagaaa ctatgctatt     5280

ggatctcctg gatctccagc ttgctgactg cagatcttga gatatgtcag cctctacagt     5340

cacaagagct aattcattct aataaaccaa tctttctgta                           5380


<210>  38
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  38

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  39
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  39
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  40
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  40

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  41
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  41
gtgatgtcgg tggccacaat tgtcatagtg gacatctgca tcactggggg cttgctgctg       60

ctggtttact actggagc                                                     78


<210>  42
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  43
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  43
atggccctga ttgtgctggg gggcgtcgcc ggcctcctgc ttttcattgg gctaggcatc       60

ttcttc                                                                  66


<210>  44
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile Leu Ala Leu Val 
1               5                   10                  15      


Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu Ala Tyr 
            20                  25                  30  


<210>  45
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  45
gcaggcctgg ccgcaggcac ggtggcaagc atcatcctgg ccctggtgct cctggtggtg       60

ctgctggtcg tgtgcggccc ccttgcctac                                        90


<210>  46
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  46

Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu Ile Phe 
1               5                   10                  15      


Ile Ala Phe Ile Leu 
            20      


<210>  47
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  47
atcccctcca tcgttctggg aattctcctc cttggctccc tcatcttcat agccttcatc       60

ctc                                                                     63


<210>  48
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  48

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  49
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  49
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

acc                                                                     63


<210>  50
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  50

Leu Leu Phe Gly Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val 
1               5                   10                  15      


Leu Ala Ile Gly Leu 
            20      


<210>  51
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  51
ctgctgttcg gatttaactt catcttctgg cttgccggga ttgctgtcct tgccattgga       60

cta                                                                     63


<210>  52
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  52

Phe Tyr Thr Gly Val Tyr Ile Leu Ile Gly Ala Gly Ala Leu Met Met 
1               5                   10                  15      


Leu Val Gly Phe Leu 
            20      


<210>  53
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  53
ttctacacag gagtctatat tctgatcgga gccggcgccc tcatgatgct ggtgggcttc       60

ctg                                                                     63


<210>  54
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile Phe Ala Ile Glu 
1               5                   10                  15      


Ile Ala Ala Ala Ile Trp Gly Tyr 
            20                  


<210>  55
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  55
atgctgggac tgttcttcgg cttcctcttg gtgatattcg ccattgaaat agctgcggcc       60

atctggggat at                                                           72


<210>  56
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  56

Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly Met 
1               5                   10                  15      


Ile Phe Ser Met Ile Leu Cys Cys Ala Ile 
            20                  25      


<210>  57
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  57
atcggcgcag tgggcatcgg cattgccgtg gtcatgatat ttggcatgat cttcagtatg       60

atcttgtgct gtgctatc                                                     78


<210>  58
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  58

Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Tyr Phe Ser Val 
            20      


<210>  59
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  59

Val Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile 
1               5                   10                  15      


Cys Gly Leu 
            


<210>  60
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Cys Leu Ile Phe Phe Ile Val 
            20              


<210>  61
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  61

Val Leu Ala Ile Ser Gly Ile Phe Thr Met Gly Ile Ala Leu Leu 
1               5                   10                  15  


<210>  62
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  62
gtcctggcca tctcaggaat cttcaccatg ggcatcgccc tcctg                       45


<210>  63
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  63

Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu Leu Phe Ala Thr Gln 
1               5                   10                  15      


Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln 
            20                  25      


<210>  64
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  64
ctcctgggcc tgtattttgg gatgctgctg ctcctgtttg ccacacagat caccctggga       60

atcctcatct ccactcag                                                     78


<210>  65
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  65

Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu Leu 
1               5                   10                  15      


Gly Phe Met Thr Leu Ser Ile Phe Leu 
            20                  25  


<210>  66
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  66
cttatttcca tagtgggcat ttgcctgggc gtcggcctac tcgagctcgg gttcatgacg       60

ctctcgatat tcctg                                                        75


<210>  67
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  67

Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe Gly 
1               5                   10                  15      


Ile Trp Ile Leu Ile 
            20      


<210>  68
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  68
ttcaacctct tcttcttcgt cctcggcagc ctgatcttct gcttcggcat ctggatcctc       60

att                                                                     63


<210>  69
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  69

Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu Val Asn Thr Val 
1               5                   10                  15      


Leu Trp Val Thr Ile 
            20      


<210>  70
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  70
gtccttttct atctggcagt gggaataatg tttttagtga acactgttct ctgggtgaca       60

ata                                                                     63


<210>  71
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  71

Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
1               5                   10                  15      


Val Ile Cys Cys Leu 
            20      


<210>  72
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  72
ctgctcccat cctgggccat taccttaatc tcagtaaatg gaatttttgt gatatgctgc       60

ctg                                                                     63


<210>  73
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  73

Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val Phe 
1               5                   10                  15      


Cys Leu Ile Leu Trp 
            20      


<210>  74
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  74

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210>  75
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  75
gttgccgcca tcctgggcct gggcctggtg ctggggctgc tgggccccct ggccatcctg       60

ctg                                                                     63


<210>  76
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  76

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  77
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  77
atcatctcct tctttcttgc gctgacgtcg actgcgttgc tcttcctgct gttcttcctc       60

acgctccgtt tctctgttgt t                                                 81


<210>  78
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  78

Ile Phe Met Tyr Leu Leu Thr Val Phe Leu Ile Thr Gln Met Ile Gly 
1               5                   10                  15      


Ser Ala Leu Phe Ala Val Tyr Leu 
            20                  


<210>  79
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  79
atttttatgt atttacttac tgtttttctt atcacccaga tgattgggtc agcacttttt       60

gctgtgtatc tt                                                           72


<210>  80
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  80

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  81
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  81

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  82
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  82
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  83
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  83

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  84
<211>  690
<212>  DNA
<213>  Homo sapiens

<400>  84
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgtg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt caactggtac      180

gtggacggcg tggaggtgca caacgccaag accaagcccc gggaggagca gttcaatagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgta aggtgtccaa caagggcctg cccagcagca tcgagaaaac catcagcaag      360

gccaagggcc agcctcggga gccccaggtg tacaccctgc cccctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gagggcaacg tctttagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaagatg                                       690


<210>  85
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  86
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  86

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  87
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  87
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  88
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  88

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  89
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  89

Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln Trp Ile 
1               5                   10                  15      


Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn His Thr 
            20                  25                  30          


Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His Val Asp 
        35                  40                  45              


Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala Tyr Pro 
    50                  55                  60                  


Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp Asn Ser 
65                  70                  75                  80  


Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                85                  90              


<210>  90
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  90

Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln 
1               5                   10                  15      


Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val Arg 
            20                  25                  30          


Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn Pro 
        35                  40                  45              


Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met 
    50                  55                  60                  


Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg Pro 
65                  70                  75                  80  


Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys Arg 
                85                  90                  95      


Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp Glu 
            100                 105                 110         


Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg Pro 
        115                 120                 125             


Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
    130                 135                 140     


<210>  91
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  91

Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu 
1               5                   10                  15      


Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser 
            20                  25                  30          


Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val 
        35                  40                  45              


Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
    50                  55                  60      


<210>  92
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  92

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  93
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  93

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  94
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  94

Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile 
        35                  40  


<210>  95
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  95

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  96
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  97
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  97

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210>  98
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  98

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  99
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  99
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  100
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Whitlow Linker

<400>  100

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


