                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
       MENG, HUAN
       SPENCER, MELISSA J.
       PYLE, APRIL D.
       YOUNG, COURTNEY S.
       LIU, XIANGSHENG
       JI, YING
       EMAMI, MICHAEL R.
 
<120>  A MULTI-ARMED POLYROTAXANE PLATFORM FOR PROTECTED NUCLEIC ACID 
       DELIVERY

<130>  UCLAP193WO

<140>  PCT/US2018/053221
<141>  2018-09-27

<150>  US 62/687,713
<151>  2017-06-20

<150>  US 62/566,100
<151>  2017-09-29

<160>  338   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  1
ctgaattagc tgtatcgtca                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  2
gaatataaac ttgtggtagt                                                   20


<210>  3
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  3

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  4

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  5
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  5

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  6
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  6

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Cys 
            20      


<210>  7
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  7

Leu Ile Lys Leu Trp Ser His Leu Ile His Ile Trp Phe Gln Asn Arg 
1               5                   10                  15      


Arg Leu Lys Trp Lys Lys Lys 
            20              


<210>  8
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  8

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  9
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  9

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  10

Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
1               5                   10                  15  


<210>  11
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Cell penetrating peptide

<400>  11

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Cas9 motif

<400>  12

Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
1               5                   10                  15  


<210>  13
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Cas9 motif

<400>  13

Ile Val Ile Glu Met Ala Arg Glu 
1               5               


<210>  14
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Cas9 motif

<400>  14

Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile 
1               5                   10                  15      


Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 
            20                  25          


<210>  15
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Cas9 motif

<400>  15

His His Ala His Asp Ala Tyr Leu 
1               5               


<210>  16
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  16
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt tt                                                82


<210>  17
<211>  82
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  17
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uu                                                82


<210>  18
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  18
aauuucuacu guuguagau                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  19
aauuucugcu guugcagau                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  20
aauuuccacu guuguggau                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  21
aauuccuacu guuguaggu                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  22
aauuucuacu auuguagau                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  23
aauuucuacu gcuguagau                                                    19


<210>  24
<211>  18
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  24
aauuucuacu uuguagau                                                     18


<210>  25
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  25
aauuucuacu uguagau                                                      17


<210>  26
<211>  67
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  26
gaauuuuuca acgggugugc caauggccac uuuccaggug gcaaagcccg uugagcuucu       60

caaaaag                                                                 67


<210>  27
<211>  79
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  27
gucuagagga cagaauuuuu caacgggugu gccaauggcc acuuuccagg uggcaaagcc       60

cguugagcuu cucaaaaag                                                    79


<210>  28
<211>  78
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  28
ucuagaggac agaauuuuuc aacgggugug ccaauggcca cuuuccaggu ggcaaagccc       60

guugagcuuc ucaaaaag                                                     78


<210>  29
<211>  36
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  29
acuuuccagg caaagcccgu ugagcuucuc aaaaag                                 36


<210>  30
<211>  9
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  30
agcuucuca                                                                9


<210>  31
<211>  8
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  31
gcuucuca                                                                 8


<210>  32
<211>  34
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence


<220>
<221>  misc_feature
<222>  (15)..(34)
<223>  n is a, c, g, or u

<400>  32
cugagaagug gcacnnnnnn nnnnnnnnnn nnnn                                   34


<210>  33
<211>  14
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  33
cugagaagug gcac                                                         14


<210>  34
<211>  9
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  34
cugagaagu                                                                9


<210>  35
<211>  13
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  35
ugagaagugg cac                                                          13


<210>  36
<211>  8
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  36
ugagaagu                                                                 8


<210>  37
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  37
gtggtgtcct ttgaatatgc                                                   20


<210>  38
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  38
gtgtcctttg aatatgc                                                      17


<210>  39
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  39
gugguguccu uugaauaugc                                                   20


<210>  40
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  40
guguccuuug aauaugc                                                      17


<210>  41
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  41
agattgtcca ggatataatt                                                   20


<210>  42
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  42
ttgtccagga tataatt                                                      17


<210>  43
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  43
agauugucca ggauauaauu                                                   20


<210>  44
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  44
uuguccagga uauaauu                                                      17


<210>  45
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  45
ttagcaacca aattatatcc                                                   20


<210>  46
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  46
gcaaccaaat tatatcc                                                      17


<210>  47
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  47
uuagcaacca aauuauaucc                                                   20


<210>  48
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  48
gcaaccaaau uauaucc                                                      17


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  49
gttgaaatta aactacacac                                                   20


<210>  50
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  50
gaaattaaac tacacac                                                      17


<210>  51
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  51
guugaaauua aacuacacac                                                   20


<210>  52
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  52
gaaauuaaac uacacac                                                      17


<210>  53
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  53
atctttacct gcatattcaa                                                   20


<210>  54
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  54
tttacctgca tattcaa                                                      17


<210>  55
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  55
aucuuuaccu gcauauucaa                                                   20


<210>  56
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  56
uuuaccugca uauucaa                                                      17


<210>  57
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  57
tacacatttt taggcttgac                                                   20


<210>  58
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  58
acatttttag gcttgac                                                      17


<210>  59
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  59
uacacauuuu uaggcuugac                                                   20


<210>  60
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  60
acauuuuuag gcuugac                                                      17


<210>  61
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  61
cattcctggg agtctgtcat                                                   20


<210>  62
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  62
tcctgggagt ctgtcat                                                      17


<210>  63
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  63
cauuccuggg agucugucau                                                   20


<210>  64
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  64
uccugggagu cugucau                                                      17


<210>  65
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  65
tgtatgatgc tataatacca                                                   20


<210>  66
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  66
atgatgctat aatacca                                                      17


<210>  67
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  67
uguaugaugc uauaauacca                                                   20


<210>  68
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  68
augaugcuau aauacca                                                      17


<210>  69
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  69
gtggaaagta cataggacct                                                   20


<210>  70
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  70
gaaagtacat aggacct                                                      17


<210>  71
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  71
guggaaagua cauaggaccu                                                   20


<210>  72
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  72
gaaaguacau aggaccu                                                      17


<210>  73
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  73
tcttatcata actcttacca                                                   20


<210>  74
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  74
tatcataact cttacca                                                      17


<210>  75
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  75
ucuuaucaua acucuuacca                                                   20


<210>  76
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  76
uaucauaacu cuuacca                                                      17


<210>  77
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  77
gtggtgtcct ttgaatatgc                                                   20


<210>  78
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  78
gugguguccu uugaauaugc                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  79
agattgtcca ggatataatt                                                   20


<210>  80
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  80
agauugucca ggauauaauu                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  81
ttagcaacca aattatatcc                                                   20


<210>  82
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  82
uuagcaacca aauuauaucc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  83
gttgaaatta aactacacac                                                   20


<210>  84
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  84
guugaaauua aacuacacac                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  85
atctttacct gcatattcaa                                                   20


<210>  86
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  86
aucuuuaccu gcauauucaa                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  87
ctctgcattg ttttggcctc                                                   20


<210>  88
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  88
cucugcauug uuuuggccuc                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  89
tcctccaaag agtagaatgg                                                   20


<210>  90
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  90
uccuccaaag aguagaaugg                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  91
gccctaaact tacactgttc                                                   20


<210>  92
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  92
gcccuaaacu uacacuguuc                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  93
aaagatagat tagattgtcc                                                   20


<210>  94
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  94
aaagauagau uagauugucc                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  95
gttgctaaat tacatagttt                                                   20


<210>  96
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  96
guugcuaaau uacauaguuu                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  97
tgttgcaata gtcaatcaag                                                   20


<210>  98
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  98
uguugcaaua gucaaucaag                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  99
atactgatta agacagatga                                                   20


<210>  100
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  100
auacugauua agacagauga                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  101
aatactgatt aagacagatg                                                   20


<210>  102
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  102
aauacugauu aagacagaug                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  103
ctctatacaa atgccaacgc                                                   20


<210>  104
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  104
cucuauacaa augccaacgc                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  105
acttgcatgc acaccagcgt                                                   20


<210>  106
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  106
acuugcaugc acaccagcgu                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  107
ttgggctaat gtagcataat                                                   20


<210>  108
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  108
uugggcuaau guagcauaau                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  109
gcgttggcat ttgtatagag                                                   20


<210>  110
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  110
gcguuggcau uuguauagag                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  111
tgggctaatg tagcataatg                                                   20


<210>  112
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  112
ugggcuaagu agcauaaug                                                    19


<210>  113
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  113
tttgggctaa tgtagcataa                                                   20


<210>  114
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  114
uuugggcuaa uguagcauaa                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  115
gcttaactcc ttaatattaa                                                   20


<210>  116
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  116
gcuuaacucc uuaauauuaa                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  117
tcttctatat taaagcagat                                                   20


<210>  118
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  118
ucuucuauau uaaagcagau                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  119
cttctatatt aaagcagatt                                                   20


<210>  120
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  120
cuucuauauu aaagcagauu                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  121
aatatataac taccttgggt                                                   20


<210>  122
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  122
aauauauaac uaccuugggu                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  123
acctccattc tactctttgg                                                   20


<210>  124
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  124
accuccauuc uacucuuugg                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  125
tttcaatgat atccaaccca                                                   20


<210>  126
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  126
uuucaaugau auccaaccca                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  127
agtacctcca ttctactctt                                                   20


<210>  128
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  128
aguaccucca uucuacucuu                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  129
ctatcctcca aagagtagaa                                                   20


<210>  130
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  130
cuauccucca aagaguagaa                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  131
ttttgctaca tatttcaggc                                                   20


<210>  132
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  132
uuuugcuaca uauuucaggc                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  133
tttgctacat atttcaggct                                                   20


<210>  134
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  134
uuugcuacau auuucaggcu                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  135
gggttggata tcattgaaaa                                                   20


<210>  136
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  136
ggguuggaua ucauugaaaa                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  137
atatttcagg ctgggtttct                                                   20


<210>  138
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  138
auauuucagg cuggguucu                                                    19


<210>  139
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  139
ttgaaatata taactacctt                                                   20


<210>  140
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  140
uugaaauaua uaacuaccuu                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  141
attgaaatat ataactacct                                                   20


<210>  142
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  142
auugaaauau auaacuaccu                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  143
gtgagtagtg gggcacttta                                                   20


<210>  144
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  144
gugaguagug gggcacuuua                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  145
tgtatgtaga aggttaacta                                                   20


<210>  146
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  146
uguauguaga agguuaacua                                                   20


<210>  147
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  147
gagcctaata aatgtacaat                                                   20


<210>  148
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  148
gagccuaaua aauguacaau                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  149
ttgtatgtag aaggttaact                                                   20


<210>  150
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  150
uuguauguag aagguuaacu                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  151
caatttgttt tgatgtaact                                                   20


<210>  152
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  152
caauuuguuu ugaguaacu                                                    19


<210>  153
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  153
tgccttctga aatagtccag                                                   20


<210>  154
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  154
ugccuucuga aauaguccag                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  155
gttaataggg aaacagcata                                                   20


<210>  156
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  156
guuaauaggg aaacagcaua                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  157
aacaatgcag agttaattgt                                                   20


<210>  158
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  158
aacaaugcag aguuaauugu                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  159
gaacatgttg agtagacaca                                                   20


<210>  160
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  160
gaacauguug aguagacaca                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  161
tttatcatct gtgtctattc                                                   20


<210>  162
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  162
uuuaucaucu gugucuauuc                                                   20


<210>  163
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  163
tctttacttt cttgactata                                                   20


<210>  164
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  164
ucuuuacuuu cuugacuaua                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  165
aatattctca aacctcgttc                                                   20


<210>  166
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  166
aauauucuca aaccucguuc                                                   20


<210>  167
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  167
attaactgtg ttccagaacg                                                   20


<210>  168
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  168
auuaacugug uuccagaacg                                                   20


<210>  169
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  169
taactgcttc tttggatgac                                                   20


<210>  170
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  170
uaacugcuuc uuuggaugac                                                   20


<210>  171
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  171
gaccagaaca gtgtaagttt                                                   20


<210>  172
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  172
gaccagaaca guguaaguuu                                                   20


<210>  173
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  173
accagaacag tgtaagttta                                                   20


<210>  174
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  174
accagaacag uguaaguuua                                                   20


<210>  175
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  175
ctactttttc cccactactg                                                   20


<210>  176
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  176
cuacuuuuuc cccacuacug                                                   20


<210>  177
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  177
tggaacacag ttaattcact                                                   20


<210>  178
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  178
uggaacacag uuaauucacu                                                   20


<210>  179
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  179
gtgttgttta actgcttctt                                                   20


<210>  180
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  180
guguuguuua acugcuucuu                                                   20


<210>  181
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  181
tacacatttt taggcttgac                                                   20


<210>  182
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  182
uacacauuuu uaggcuugac                                                   20


<210>  183
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  183
cattcctggg agtctgtcat                                                   20


<210>  184
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  184
cauuccuggg agucugucau                                                   20


<210>  185
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  185
tgtatgatgc tataatacca                                                   20


<210>  186
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  186
uguaugaugc uauaauacca                                                   20


<210>  187
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  187
gtggaaagta cataggacct                                                   20


<210>  188
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  188
guggaaagua cauaggaccu                                                   20


<210>  189
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  189
tcttatcata actcttacca                                                   20


<210>  190
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  190
ucuuaucaua acucuuacca                                                   20


<210>  191
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  191
aactgtcagt tgcatattcc                                                   20


<210>  192
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  192
aacugucagu ugcauauucc                                                   20


<210>  193
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  193
cagaaaggaa tgctggtacc                                                   20


<210>  194
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  194
cagaaaggaa ugcugguacc                                                   20


<210>  195
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  195
tctgcctaca caatgaatgg                                                   20


<210>  196
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  196
ucugccuaca caaugaaugg                                                   20


<210>  197
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  197
cacagatcaa tccaattgtt                                                   20


<210>  198
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  198
cacagaucaa uccaauuguu                                                   20


<210>  199
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  199
ttgacaggtg gaaagtacat                                                   20


<210>  200
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  200
uugacaggug gaaaguacau                                                   20


<210>  201
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  201
acatttttag gcttgacagg                                                   20


<210>  202
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  202
acauuuuuag gcuugacagg                                                   20


<210>  203
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  203
ctctcccatg acagactccc                                                   20


<210>  204
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  204
cucucccaug acagacuccc                                                   20


<210>  205
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  205
ttggtaagag ttatgataag                                                   20


<210>  206
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  206
uugguaagag uuaugauaag                                                   20


<210>  207
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  207
aacacaaatt aagttcacct                                                   20


<210>  208
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  208
aacacaaauu aaguucaccu                                                   20


<210>  209
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  209
aggatcagtg ctgtagtgcc                                                   20


<210>  210
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  210
aggaucagug cuguagugcc                                                   20


<210>  211
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  211
ggccgtttat tattattgac                                                   20


<210>  212
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  212
ggccguuuau uauuauugac                                                   20


<210>  213
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  213
tctcaggatt gctatgcaac                                                   20


<210>  214
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  214
ucucaggauu gcuaugcaac                                                   20


<210>  215
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  215
caggaagaca taccatgtaa                                                   20


<210>  216
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  216
caggaagaca uaccauguaa                                                   20


<210>  217
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  217
agcagggctc tttcagtttc                                                   20


<210>  218
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  218
agcagggcuc uuucaguuuc                                                   20


<210>  219
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  219
taacattttc agcttgaacc                                                   20


<210>  220
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  220
uaacauuuuc agcuugaacc                                                   20


<210>  221
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  221
tcaagctgaa aatgttacac                                                   20


<210>  222
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  222
ucaagcugaa aauguuacac                                                   20


<210>  223
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  223
gtaacatttt cagcttgaac                                                   20


<210>  224
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  224
guaacauuuu cagcuugaac                                                   20


<210>  225
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  225
cagaatgaat tttggagcac                                                   20


<210>  226
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  226
cagaaugaau uuuggagcac                                                   20


<210>  227
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  227
tttattatta ttgactggtg                                                   20


<210>  228
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  228
uuuauuauua uugacuggug                                                   20


<210>  229
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  229
agaagaatct gacctttaca                                                   20


<210>  230
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  230
agaagaaucu gaccuuuaca                                                   20


<210>  231
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  231
gcagggctct ttcagtttct                                                   20


<210>  232
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  232
gcagggcucu uucaguuucu                                                   20


<210>  233
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  233
ctaaacagta gccaggcgtg                                                   20


<210>  234
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  234
cuaaacagua gccaggcgug                                                   20


<210>  235
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  235
cgcctggcta ctgtttagtg                                                   20


<210>  236
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  236
cgccuggcua cuguuuagug                                                   20


<210>  237
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  237
ctccgcacta aacagtagcc                                                   20


<210>  238
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  238
cuccgcacua aacaguagcc                                                   20


<210>  239
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  239
gtagccaggc gtgtggatgt                                                   20


<210>  240
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  240
guagccaggc guguggaugu                                                   20


<210>  241
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  241
cttggctttg actattctgc                                                   20


<210>  242
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  242
cuuggcuuug acuauucugc                                                   20


<210>  243
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  243
agtagccagg cgtgtggatg                                                   20


<210>  244
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  244
aguagccagg cguguggaug                                                   20


<210>  245
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  245
tcctcccaca tccacacgcc                                                   20


<210>  246
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  246
uccucccaca uccacacgcc                                                   20


<210>  247
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  247
ttggctttga ctattctgct                                                   20


<210>  248
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  248
uuggcuuuga cuauucugcu                                                   20


<210>  249
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  249
ataatgtctc tggcttgtaa                                                   20


<210>  250
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  250
auaaugucuc uggcuuguaa                                                   20


<210>  251
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  251
tggtacccgg cagctctctg                                                   20


<210>  252
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  252
ugguacccgg cagcucucug                                                   20


<210>  253
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  253
gtgggaggaa cctcaaagag                                                   20


<210>  254
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  254
gugggaggaa ccucaaagag                                                   20


<210>  255
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  255
tgactattct gctgggaaca                                                   20


<210>  256
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  256
ugacuauucu gcugggaaca                                                   20


<210>  257
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  257
ctctctgagg aatgttccct                                                   20


<210>  258
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  258
cucucugagg aauguucccu                                                   20


<210>  259
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  259
aacattcctc agagagctgc                                                   20


<210>  260
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  260
aacauuccuc agagagcugc                                                   20


<210>  261
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  261
attctgaagc tccaaacaat                                                   20


<210>  262
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  262
auucugaagc uccaaacaau                                                   20


<210>  263
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  263
taaattactc tgctaaagta                                                   20


<210>  264
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  264
uaaauuacuc ugcuaaagua                                                   20


<210>  265
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  265
agtacaaacc aggtttgtac                                                   20


<210>  266
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  266
aguacaaacc agguuuguac                                                   20


<210>  267
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  267
atatccttcc agtacaaacc                                                   20


<210>  268
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  268
auauccuucc aguacaaacc                                                   20


<210>  269
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  269
caaaccaggt ttgtactgga                                                   20


<210>  270
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  270
caaaccaggu uuguacugga                                                   20


<210>  271
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  271
ggcagctaaa gcatcactga                                                   20


<210>  272
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  272
ggcagcuaaa gcaucacuga                                                   20


<210>  273
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  273
atctctgagt agtacaaacc                                                   20


<210>  274
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  274
aucucugagu aguacaaacc                                                   20


<210>  275
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  275
gtgtcccatt ctctttgact                                                   20


<210>  276
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  276
gugucccauu cucuuugacu                                                   20


<210>  277
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  277
tgtgtcccat tctctttgac                                                   20


<210>  278
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  278
ugugucccau ucucuuugac                                                   20


<210>  279
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  279
ttctgaatgt tgaacaagta                                                   20


<210>  280
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  280
uucugaaugu ugaacaagua                                                   20


<210>  281
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  281
gtctcccagt caaagagaat                                                   20


<210>  282
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  282
gucucccagu caaagagaau                                                   20


<210>  283
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  283
attctctttg actgggagac                                                   20


<210>  284
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  284
auucucuuug acugggagac                                                   20


<210>  285
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  285
tctttgactg ggagacaggc                                                   20


<210>  286
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  286
ucuuugacug ggagacaggc                                                   20


<210>  287
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  287
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgctttt tt                                                82


<210>  288
<211>  11
<212>  PRT
<213>  human immunodeficiency virus

<400>  288

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  289
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  289

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  290
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  290

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  291
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  291

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  292
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  292

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  293
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  293

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  294
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  294

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  295
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  295

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  296
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  296

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  297
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  297

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  298
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  298

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  299
<211>  82
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  299
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcuuuu uu                                                82


<210>  300
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  300
aacctcacct gtacacgcc                                                    19


<210>  301
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  301
caagtccatg tttctttgca cg                                                22


<210>  302
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  302
agagctacga gctgcctgac                                                   20


<210>  303
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  303
agcactgtgt tggcgtacag                                                   20


<210>  304
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  304
gaaauuaaac uacacac                                                      17


<210>  305
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  305
augaugcuau aauacca                                                      17


<210>  306
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  306
guugaaauua aacuacacac                                                   20


<210>  307
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  307
uguaugaugc uauaauacca                                                   20


<210>  308
<211>  1368
<212>  PRT
<213>  S. pyrogenes

<400>  308

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  309
<211>  1300
<212>  PRT
<213>  Francisella  tularensis

<400>  309

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  310
<211>  1307
<212>  PRT
<213>  Artificial

<220>
<223>  CPF1 peptide

<400>  310

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  311
<211>  1246
<212>  PRT
<213>  Artificial

<220>
<223>  CPF1 peptide

<400>  311

Met Leu Lys Asn Val Gly Ile Asp Arg Leu Asp Val Glu Lys Gly Arg 
1               5                   10                  15      


Lys Asn Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Arg Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His 
    1235                 1240                 1245     


<210>  312
<211>  1246
<212>  PRT
<213>  Porphyromonas macacae

<400>  312

Met Lys Thr Gln His Phe Phe Glu Asp Phe Thr Ser Leu Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Ile Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu 
            20                  25                  30          


Asn Ile Lys Lys Asn Gly Leu Ile Arg Arg Asp Glu Gln Arg Leu Asp 
        35                  40                  45              


Asp Tyr Glu Lys Leu Lys Lys Val Ile Asp Glu Tyr His Glu Asp Phe 
    50                  55                  60                  


Ile Ala Asn Ile Leu Ser Ser Phe Ser Phe Ser Glu Glu Ile Leu Gln 
65                  70                  75                  80  


Ser Tyr Ile Gln Asn Leu Ser Glu Ser Glu Ala Arg Ala Lys Ile Glu 
                85                  90                  95      


Lys Thr Met Arg Asp Thr Leu Ala Lys Ala Phe Ser Glu Asp Glu Arg 
            100                 105                 110         


Tyr Lys Ser Ile Phe Lys Lys Glu Leu Val Lys Lys Asp Ile Pro Val 
        115                 120                 125             


Trp Cys Pro Ala Tyr Lys Ser Leu Cys Lys Lys Phe Asp Asn Phe Thr 
    130                 135                 140                 


Thr Ser Leu Val Pro Phe His Glu Asn Arg Lys Asn Leu Tyr Thr Ser 
145                 150                 155                 160 


Asn Glu Ile Thr Ala Ser Ile Pro Tyr Arg Ile Val His Val Asn Leu 
                165                 170                 175     


Pro Lys Phe Ile Gln Asn Ile Glu Ala Leu Cys Glu Leu Gln Lys Lys 
            180                 185                 190         


Met Gly Ala Asp Leu Tyr Leu Glu Met Met Glu Asn Leu Arg Asn Val 
        195                 200                 205             


Trp Pro Ser Phe Val Lys Thr Pro Asp Asp Leu Cys Asn Leu Lys Thr 
    210                 215                 220                 


Tyr Asn His Leu Met Val Gln Ser Ser Ile Ser Glu Tyr Asn Arg Phe 
225                 230                 235                 240 


Val Gly Gly Tyr Ser Thr Glu Asp Gly Thr Lys His Gln Gly Ile Asn 
                245                 250                 255     


Glu Trp Ile Asn Ile Tyr Arg Gln Arg Asn Lys Glu Met Arg Leu Pro 
            260                 265                 270         


Gly Leu Val Phe Leu His Lys Gln Ile Leu Ala Lys Val Asp Ser Ser 
        275                 280                 285             


Ser Phe Ile Ser Asp Thr Leu Glu Asn Asp Asp Gln Val Phe Cys Val 
    290                 295                 300                 


Leu Arg Gln Phe Arg Lys Leu Phe Trp Asn Thr Val Ser Ser Lys Glu 
305                 310                 315                 320 


Asp Asp Ala Ala Ser Leu Lys Asp Leu Phe Cys Gly Leu Ser Gly Tyr 
                325                 330                 335     


Asp Pro Glu Ala Ile Tyr Val Ser Asp Ala His Leu Ala Thr Ile Ser 
            340                 345                 350         


Lys Asn Ile Phe Asp Arg Trp Asn Tyr Ile Ser Asp Ala Ile Arg Arg 
        355                 360                 365             


Lys Thr Glu Val Leu Met Pro Arg Lys Lys Glu Ser Val Glu Arg Tyr 
    370                 375                 380                 


Ala Glu Lys Ile Ser Lys Gln Ile Lys Lys Arg Gln Ser Tyr Ser Leu 
385                 390                 395                 400 


Ala Glu Leu Asp Asp Leu Leu Ala His Tyr Ser Glu Glu Ser Leu Pro 
                405                 410                 415     


Ala Gly Phe Ser Leu Leu Ser Tyr Phe Thr Ser Leu Gly Gly Gln Lys 
            420                 425                 430         


Tyr Leu Val Ser Asp Gly Glu Val Ile Leu Tyr Glu Glu Gly Ser Asn 
        435                 440                 445             


Ile Trp Asp Glu Val Leu Ile Ala Phe Arg Asp Leu Gln Val Ile Leu 
    450                 455                 460                 


Asp Lys Asp Phe Thr Glu Lys Lys Leu Gly Lys Asp Glu Glu Ala Val 
465                 470                 475                 480 


Ser Val Ile Lys Lys Ala Leu Asp Ser Ala Leu Arg Leu Arg Lys Phe 
                485                 490                 495     


Phe Asp Leu Leu Ser Gly Thr Gly Ala Glu Ile Arg Arg Asp Ser Ser 
            500                 505                 510         


Phe Tyr Ala Leu Tyr Thr Asp Arg Met Asp Lys Leu Lys Gly Leu Leu 
        515                 520                 525             


Lys Met Tyr Asp Lys Val Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser 
    530                 535                 540                 


Ile Glu Lys Phe Lys Leu His Phe Asp Asn Pro Ser Leu Leu Ser Gly 
545                 550                 555                 560 


Trp Asp Lys Asn Lys Glu Leu Asn Asn Leu Ser Val Ile Phe Arg Gln 
                565                 570                 575     


Asn Gly Tyr Tyr Tyr Leu Gly Ile Met Thr Pro Lys Gly Lys Asn Leu 
            580                 585                 590         


Phe Lys Thr Leu Pro Lys Leu Gly Ala Glu Glu Met Phe Tyr Glu Lys 
        595                 600                 605             


Met Glu Tyr Lys Gln Ile Ala Glu Pro Met Leu Met Leu Pro Lys Val 
    610                 615                 620                 


Phe Phe Pro Lys Lys Thr Lys Pro Ala Phe Ala Pro Asp Gln Ser Val 
625                 630                 635                 640 


Val Asp Ile Tyr Asn Lys Lys Thr Phe Lys Thr Gly Gln Lys Gly Phe 
                645                 650                 655     


Asn Lys Lys Asp Leu Tyr Arg Leu Ile Asp Phe Tyr Lys Glu Ala Leu 
            660                 665                 670         


Thr Val His Glu Trp Lys Leu Phe Asn Phe Ser Phe Ser Pro Thr Glu 
        675                 680                 685             


Gln Tyr Arg Asn Ile Gly Glu Phe Phe Asp Glu Val Arg Glu Gln Ala 
    690                 695                 700                 


Tyr Lys Val Ser Met Val Asn Val Pro Ala Ser Tyr Ile Asp Glu Ala 
705                 710                 715                 720 


Val Glu Asn Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
                725                 730                 735     


Ser Pro Tyr Ser Lys Gly Ile Pro Asn Leu His Thr Leu Tyr Trp Lys 
            740                 745                 750         


Ala Leu Phe Ser Glu Gln Asn Gln Ser Arg Val Tyr Lys Leu Cys Gly 
        755                 760                 765             


Gly Gly Glu Leu Phe Tyr Arg Lys Ala Ser Leu His Met Gln Asp Thr 
    770                 775                 780                 


Thr Val His Pro Lys Gly Ile Ser Ile His Lys Lys Asn Leu Asn Lys 
785                 790                 795                 800 


Lys Gly Glu Thr Ser Leu Phe Asn Tyr Asp Leu Val Lys Asp Lys Arg 
                805                 810                 815     


Phe Thr Glu Asp Lys Phe Phe Phe His Val Pro Ile Ser Ile Asn Tyr 
            820                 825                 830         


Lys Asn Lys Lys Ile Thr Asn Val Asn Gln Met Val Arg Asp Tyr Ile 
        835                 840                 845             


Ala Gln Asn Asp Asp Leu Gln Ile Ile Gly Ile Asp Arg Gly Glu Arg 
    850                 855                 860                 


Asn Leu Leu Tyr Ile Ser Arg Ile Asp Thr Arg Gly Asn Leu Leu Glu 
865                 870                 875                 880 


Gln Phe Ser Leu Asn Val Ile Glu Ser Asp Lys Gly Asp Leu Arg Thr 
                885                 890                 895     


Asp Tyr Gln Lys Ile Leu Gly Asp Arg Glu Gln Glu Arg Leu Arg Arg 
            900                 905                 910         


Arg Gln Glu Trp Lys Ser Ile Glu Ser Ile Lys Asp Leu Lys Asp Gly 
        915                 920                 925             


Tyr Met Ser Gln Val Val His Lys Ile Cys Asn Met Val Val Glu His 
    930                 935                 940                 


Lys Ala Ile Val Val Leu Glu Asn Leu Asn Leu Ser Phe Met Lys Gly 
945                 950                 955                 960 


Arg Lys Lys Val Glu Lys Ser Val Tyr Glu Lys Phe Glu Arg Met Leu 
                965                 970                 975     


Val Asp Lys Leu Asn Tyr Leu Val Val Asp Lys Lys Asn Leu Ser Asn 
            980                 985                 990         


Glu Pro Gly Gly Leu Tyr Ala Ala  Tyr Gln Leu Thr Asn  Pro Leu Phe 
        995                 1000                 1005             


Ser Phe  Glu Glu Leu His Arg  Tyr Pro Gln Ser Gly  Ile Leu Phe 
    1010                 1015                 1020             


Phe Val  Asp Pro Trp Asn Thr  Ser Leu Thr Asp Pro  Ser Thr Gly 
    1025                 1030                 1035             


Phe Val  Asn Leu Leu Gly Arg  Ile Asn Tyr Thr Asn  Val Gly Asp 
    1040                 1045                 1050             


Ala Arg  Lys Phe Phe Asp Arg  Phe Asn Ala Ile Arg  Tyr Asp Gly 
    1055                 1060                 1065             


Lys Gly  Asn Ile Leu Phe Asp  Leu Asp Leu Ser Arg  Phe Asp Val 
    1070                 1075                 1080             


Arg Val  Glu Thr Gln Arg Lys  Leu Trp Thr Leu Thr  Thr Phe Gly 
    1085                 1090                 1095             


Ser Arg  Ile Ala Lys Ser Lys  Lys Ser Gly Lys Trp  Met Val Glu 
    1100                 1105                 1110             


Arg Ile  Glu Asn Leu Ser Leu  Cys Phe Leu Glu Leu  Phe Glu Gln 
    1115                 1120                 1125             


Phe Asn  Ile Gly Tyr Arg Val  Glu Lys Asp Leu Lys  Lys Ala Ile 
    1130                 1135                 1140             


Leu Ser  Gln Asp Arg Lys Glu  Phe Tyr Val Arg Leu  Ile Tyr Leu 
    1145                 1150                 1155             


Phe Asn  Leu Met Met Gln Ile  Arg Asn Ser Asp Gly  Glu Glu Asp 
    1160                 1165                 1170             


Tyr Ile  Leu Ser Pro Ala Leu  Asn Glu Lys Asn Leu  Gln Phe Asp 
    1175                 1180                 1185             


Ser Arg  Leu Ile Glu Ala Lys  Asp Leu Pro Val Asp  Ala Asp Ala 
    1190                 1195                 1200             


Asn Gly  Ala Tyr Asn Val Ala  Arg Lys Gly Leu Met  Val Val Gln 
    1205                 1210                 1215             


Arg Ile  Lys Arg Gly Asp His  Glu Ser Ile His Arg  Ile Gly Arg 
    1220                 1225                 1230             


Ala Gln  Trp Leu Arg Tyr Val  Gln Glu Gly Ile Val  Glu 
    1235                 1240                 1245     


<210>  313
<211>  1326
<212>  PRT
<213>  Prevotella  disiens

<400>  313

Met Lys Val Met Glu Asn Tyr Gln Glu Phe Thr Asn Leu Phe Gln Leu 
1               5                   10                  15      


Asn Lys Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Cys Glu 
            20                  25                  30          


Leu Leu Glu Glu Gly Lys Ile Phe Ala Ser Gly Ser Phe Leu Glu Lys 
        35                  40                  45              


Asp Lys Val Arg Ala Asp Asn Val Ser Tyr Val Lys Lys Glu Ile Asp 
    50                  55                  60                  


Lys Lys His Lys Ile Phe Ile Glu Glu Thr Leu Ser Ser Phe Ser Ile 
65                  70                  75                  80  


Ser Asn Asp Leu Leu Lys Gln Tyr Phe Asp Cys Tyr Asn Glu Leu Lys 
                85                  90                  95      


Ala Phe Lys Lys Asp Cys Lys Ser Asp Glu Glu Glu Val Lys Lys Thr 
            100                 105                 110         


Ala Leu Arg Asn Lys Cys Thr Ser Ile Gln Arg Ala Met Arg Glu Ala 
        115                 120                 125             


Ile Ser Gln Ala Phe Leu Lys Ser Pro Gln Lys Lys Leu Leu Ala Ile 
    130                 135                 140                 


Lys Asn Leu Ile Glu Asn Val Phe Lys Ala Asp Glu Asn Val Gln His 
145                 150                 155                 160 


Phe Ser Glu Phe Thr Ser Tyr Phe Ser Gly Phe Glu Thr Asn Arg Glu 
                165                 170                 175     


Asn Phe Tyr Ser Asp Glu Glu Lys Ser Thr Ser Ile Ala Tyr Arg Leu 
            180                 185                 190         


Val His Asp Asn Leu Pro Ile Phe Ile Lys Asn Ile Tyr Ile Phe Glu 
        195                 200                 205             


Lys Leu Lys Glu Gln Phe Asp Ala Lys Thr Leu Ser Glu Ile Phe Glu 
    210                 215                 220                 


Asn Tyr Lys Leu Tyr Val Ala Gly Ser Ser Leu Asp Glu Val Phe Ser 
225                 230                 235                 240 


Leu Glu Tyr Phe Asn Asn Thr Leu Thr Gln Lys Gly Ile Asp Asn Tyr 
                245                 250                 255     


Asn Ala Val Ile Gly Lys Ile Val Lys Glu Asp Lys Gln Glu Ile Gln 
            260                 265                 270         


Gly Leu Asn Glu His Ile Asn Leu Tyr Asn Gln Lys His Lys Asp Arg 
        275                 280                 285             


Arg Leu Pro Phe Phe Ile Ser Leu Lys Lys Gln Ile Leu Ser Asp Arg 
    290                 295                 300                 


Glu Ala Leu Ser Trp Leu Pro Asp Met Phe Lys Asn Asp Ser Glu Val 
305                 310                 315                 320 


Ile Lys Ala Leu Lys Gly Phe Tyr Ile Glu Asp Gly Phe Glu Asn Asn 
                325                 330                 335     


Val Leu Thr Pro Leu Ala Thr Leu Leu Ser Ser Leu Asp Lys Tyr Asn 
            340                 345                 350         


Leu Asn Gly Ile Phe Ile Arg Asn Asn Glu Ala Leu Ser Ser Leu Ser 
        355                 360                 365             


Gln Asn Val Tyr Arg Asn Phe Ser Ile Asp Glu Ala Ile Asp Ala Asn 
    370                 375                 380                 


Ala Glu Leu Gln Thr Phe Asn Asn Tyr Glu Leu Ile Ala Asn Ala Leu 
385                 390                 395                 400 


Arg Ala Lys Ile Lys Lys Glu Thr Lys Gln Gly Arg Lys Ser Phe Glu 
                405                 410                 415     


Lys Tyr Glu Glu Tyr Ile Asp Lys Lys Val Lys Ala Ile Asp Ser Leu 
            420                 425                 430         


Ser Ile Gln Glu Ile Asn Glu Leu Val Glu Asn Tyr Val Ser Glu Phe 
        435                 440                 445             


Asn Ser Asn Ser Gly Asn Met Pro Arg Lys Val Glu Asp Tyr Phe Ser 
    450                 455                 460                 


Leu Met Arg Lys Gly Asp Phe Gly Ser Asn Asp Leu Ile Glu Asn Ile 
465                 470                 475                 480 


Lys Thr Lys Leu Ser Ala Ala Glu Lys Leu Leu Gly Thr Lys Tyr Gln 
                485                 490                 495     


Glu Thr Ala Lys Asp Ile Phe Lys Lys Asp Glu Asn Ser Lys Leu Ile 
            500                 505                 510         


Lys Glu Leu Leu Asp Ala Thr Lys Gln Phe Gln His Phe Ile Lys Pro 
        515                 520                 525             


Leu Leu Gly Thr Gly Glu Glu Ala Asp Arg Asp Leu Val Phe Tyr Gly 
    530                 535                 540                 


Asp Phe Leu Pro Leu Tyr Glu Lys Phe Glu Glu Leu Thr Leu Leu Tyr 
545                 550                 555                 560 


Asn Lys Val Arg Asn Arg Leu Thr Gln Lys Pro Tyr Ser Lys Asp Lys 
                565                 570                 575     


Ile Arg Leu Cys Phe Asn Lys Pro Lys Leu Met Thr Gly Trp Val Asp 
            580                 585                 590         


Ser Lys Thr Glu Lys Ser Asp Asn Gly Thr Gln Tyr Gly Gly Tyr Leu 
        595                 600                 605             


Phe Arg Lys Lys Asn Glu Ile Gly Glu Tyr Asp Tyr Phe Leu Gly Ile 
    610                 615                 620                 


Ser Ser Lys Ala Gln Leu Phe Arg Lys Asn Glu Ala Val Ile Gly Asp 
625                 630                 635                 640 


Tyr Glu Arg Leu Asp Tyr Tyr Gln Pro Lys Ala Asn Thr Ile Tyr Gly 
                645                 650                 655     


Ser Ala Tyr Glu Gly Glu Asn Ser Tyr Lys Glu Asp Lys Lys Arg Leu 
            660                 665                 670         


Asn Lys Val Ile Ile Ala Tyr Ile Glu Gln Ile Lys Gln Thr Asn Ile 
        675                 680                 685             


Lys Lys Ser Ile Ile Glu Ser Ile Ser Lys Tyr Pro Asn Ile Ser Asp 
    690                 695                 700                 


Asp Asp Lys Val Thr Pro Ser Ser Leu Leu Glu Lys Ile Lys Lys Val 
705                 710                 715                 720 


Ser Ile Asp Ser Tyr Asn Gly Ile Leu Ser Phe Lys Ser Phe Gln Ser 
                725                 730                 735     


Val Asn Lys Glu Val Ile Asp Asn Leu Leu Lys Thr Ile Ser Pro Leu 
            740                 745                 750         


Lys Asn Lys Ala Glu Phe Leu Asp Leu Ile Asn Lys Asp Tyr Gln Ile 
        755                 760                 765             


Phe Thr Glu Val Gln Ala Val Ile Asp Glu Ile Cys Lys Gln Lys Thr 
    770                 775                 780                 


Phe Ile Tyr Phe Pro Ile Ser Asn Val Glu Leu Glu Lys Glu Met Gly 
785                 790                 795                 800 


Asp Lys Asp Lys Pro Leu Cys Leu Phe Gln Ile Ser Asn Lys Asp Leu 
                805                 810                 815     


Ser Phe Ala Lys Thr Phe Ser Ala Asn Leu Arg Lys Lys Arg Gly Ala 
            820                 825                 830         


Glu Asn Leu His Thr Met Leu Phe Lys Ala Leu Met Glu Gly Asn Gln 
        835                 840                 845             


Asp Asn Leu Asp Leu Gly Ser Gly Ala Ile Phe Tyr Arg Ala Lys Ser 
    850                 855                 860                 


Leu Asp Gly Asn Lys Pro Thr His Pro Ala Asn Glu Ala Ile Lys Cys 
865                 870                 875                 880 


Arg Asn Val Ala Asn Lys Asp Lys Val Ser Leu Phe Thr Tyr Asp Ile 
                885                 890                 895     


Tyr Lys Asn Arg Arg Tyr Met Glu Asn Lys Phe Leu Phe His Leu Ser 
            900                 905                 910         


Ile Val Gln Asn Tyr Lys Ala Ala Asn Asp Ser Ala Gln Leu Asn Ser 
        915                 920                 925             


Ser Ala Thr Glu Tyr Ile Arg Lys Ala Asp Asp Leu His Ile Ile Gly 
    930                 935                 940                 


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Tyr Ser Val Ile Asp Met 
945                 950                 955                 960 


Lys Gly Asn Ile Val Glu Gln Asp Ser Leu Asn Ile Ile Arg Asn Asn 
                965                 970                 975     


Asp Leu Glu Thr Asp Tyr His Asp Leu Leu Asp Lys Arg Glu Lys Glu 
            980                 985                 990         


Arg Lys Ala Asn Arg Gln Asn Trp  Glu Ala Val Glu Gly  Ile Lys Asp 
        995                 1000                 1005             


Leu Lys  Lys Gly Tyr Leu Ser  Gln Ala Val His Gln  Ile Ala Gln 
    1010                 1015                 1020             


Leu Met  Leu Lys Tyr Asn Ala  Ile Ile Ala Leu Glu  Asp Leu Gly 
    1025                 1030                 1035             


Gln Met  Phe Val Thr Arg Gly  Gln Lys Ile Glu Lys  Ala Val Tyr 
    1040                 1045                 1050             


Gln Gln  Phe Glu Lys Ser Leu  Val Asp Lys Leu Ser  Tyr Leu Val 
    1055                 1060                 1065             


Asp Lys  Lys Arg Pro Tyr Asn  Glu Leu Gly Gly Ile  Leu Lys Ala 
    1070                 1075                 1080             


Tyr Gln  Leu Ala Ser Ser Ile  Thr Lys Asn Asn Ser  Asp Lys Gln 
    1085                 1090                 1095             


Asn Gly  Phe Leu Phe Tyr Val  Pro Ala Trp Asn Thr  Ser Lys Ile 
    1100                 1105                 1110             


Asp Pro  Val Thr Gly Phe Thr  Asp Leu Leu Arg Pro  Lys Ala Met 
    1115                 1120                 1125             


Thr Ile  Lys Glu Ala Gln Asp  Phe Phe Gly Ala Phe  Asp Asn Ile 
    1130                 1135                 1140             


Ser Tyr  Asn Asp Lys Gly Tyr  Phe Glu Phe Glu Thr  Asn Tyr Asp 
    1145                 1150                 1155             


Lys Phe  Lys Ile Arg Met Lys  Ser Ala Gln Thr Arg  Trp Thr Ile 
    1160                 1165                 1170             


Cys Thr  Phe Gly Asn Arg Ile  Lys Arg Lys Lys Asp  Lys Asn Tyr 
    1175                 1180                 1185             


Trp Asn  Tyr Glu Glu Val Glu  Leu Thr Glu Glu Phe  Lys Lys Leu 
    1190                 1195                 1200             


Phe Lys  Asp Ser Asn Ile Asp  Tyr Glu Asn Cys Asn  Leu Lys Glu 
    1205                 1210                 1215             


Glu Ile  Gln Asn Lys Asp Asn  Arg Lys Phe Phe Asp  Asp Leu Ile 
    1220                 1225                 1230             


Lys Leu  Leu Gln Leu Thr Leu  Gln Met Arg Asn Ser  Asp Asp Lys 
    1235                 1240                 1245             


Gly Asn  Asp Tyr Ile Ile Ser  Pro Val Ala Asn Ala  Glu Gly Gln 
    1250                 1255                 1260             


Phe Phe  Asp Ser Arg Asn Gly  Asp Lys Lys Leu Pro  Leu Asp Ala 
    1265                 1270                 1275             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Gly  Leu Trp Asn 
    1280                 1285                 1290             


Ile Arg  Gln Ile Lys Gln Thr  Lys Asn Asp Lys Lys  Leu Asn Leu 
    1295                 1300                 1305             


Ser Ile  Ser Ser Thr Glu Trp  Leu Asp Phe Val Arg  Glu Lys Pro 
    1310                 1315                 1320             


Tyr Leu  Lys 
    1325     


<210>  314
<211>  1129
<212>  PRT
<213>  Alicyclobacillus acidoterrestris

<400>  314

Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Asp Asp Met Pro 
1               5                   10                  15      


Glu Ile Arg Ala Gly Leu Trp Lys Leu His Lys Glu Val Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ser Leu Leu Arg Gln Glu Asn Leu 
        35                  40                  45              


Tyr Arg Arg Ser Pro Asn Gly Asp Gly Glu Gln Glu Cys Asp Lys Thr 
    50                  55                  60                  


Ala Glu Glu Cys Lys Ala Glu Leu Leu Glu Arg Leu Arg Ala Arg Gln 
65                  70                  75                  80  


Val Glu Asn Gly His Arg Gly Pro Ala Gly Ser Asp Asp Glu Leu Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln Leu Tyr Glu Leu Leu Val Pro Gln Ala Ile Gly 
            100                 105                 110         


Ala Lys Gly Asp Ala Gln Gln Ile Ala Arg Lys Phe Leu Ser Pro Leu 
        115                 120                 125             


Ala Asp Lys Asp Ala Val Gly Gly Leu Gly Ile Ala Lys Ala Gly Asn 
    130                 135                 140                 


Lys Pro Arg Trp Val Arg Met Arg Glu Ala Gly Glu Pro Gly Trp Glu 
145                 150                 155                 160 


Glu Glu Lys Glu Lys Ala Glu Thr Arg Lys Ser Ala Asp Arg Thr Ala 
                165                 170                 175     


Asp Val Leu Arg Ala Leu Ala Asp Phe Gly Leu Lys Pro Leu Met Arg 
            180                 185                 190         


Val Tyr Thr Asp Ser Glu Met Ser Ser Val Glu Trp Lys Pro Leu Arg 
        195                 200                 205             


Lys Gly Gln Ala Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala 
    210                 215                 220                 


Ile Glu Arg Met Met Ser Trp Glu Ser Trp Asn Gln Arg Val Gly Gln 
225                 230                 235                 240 


Glu Tyr Ala Lys Leu Val Glu Gln Lys Asn Arg Phe Glu Gln Lys Asn 
                245                 250                 255     


Phe Val Gly Gln Glu His Leu Val His Leu Val Asn Gln Leu Gln Gln 
            260                 265                 270         


Asp Met Lys Glu Ala Ser Pro Gly Leu Glu Ser Lys Glu Gln Thr Ala 
        275                 280                 285             


His Tyr Val Thr Gly Arg Ala Leu Arg Gly Ser Asp Lys Val Phe Glu 
    290                 295                 300                 


Lys Trp Gly Lys Leu Ala Pro Asp Ala Pro Phe Asp Leu Tyr Asp Ala 
305                 310                 315                 320 


Glu Ile Lys Asn Val Gln Arg Arg Asn Thr Arg Arg Phe Gly Ser His 
                325                 330                 335     


Asp Leu Phe Ala Lys Leu Ala Glu Pro Glu Tyr Gln Ala Leu Trp Arg 
            340                 345                 350         


Glu Asp Ala Ser Phe Leu Thr Arg Tyr Ala Val Tyr Asn Ser Ile Leu 
        355                 360                 365             


Arg Lys Leu Asn His Ala Lys Met Phe Ala Thr Phe Thr Leu Pro Asp 
    370                 375                 380                 


Ala Thr Ala His Pro Ile Trp Thr Arg Phe Asp Lys Leu Gly Gly Asn 
385                 390                 395                 400 


Leu His Gln Tyr Thr Phe Leu Phe Asn Glu Phe Gly Glu Arg Arg His 
                405                 410                 415     


Ala Ile Arg Phe His Lys Leu Leu Lys Val Glu Asn Gly Val Ala Arg 
            420                 425                 430         


Glu Val Asp Asp Val Thr Val Pro Ile Ser Met Ser Glu Gln Leu Asp 
        435                 440                 445             


Asn Leu Leu Pro Arg Asp Pro Asn Glu Pro Ile Ala Leu Tyr Phe Arg 
    450                 455                 460                 


Asp Tyr Gly Ala Glu Gln His Phe Thr Gly Glu Phe Gly Gly Ala Lys 
465                 470                 475                 480 


Ile Gln Cys Arg Arg Asp Gln Leu Ala His Met His Arg Arg Arg Gly 
                485                 490                 495     


Ala Arg Asp Val Tyr Leu Asn Val Ser Val Arg Val Gln Ser Gln Ser 
            500                 505                 510         


Glu Ala Arg Gly Glu Arg Arg Pro Pro Tyr Ala Ala Val Phe Arg Leu 
        515                 520                 525             


Val Gly Asp Asn His Arg Ala Phe Val His Phe Asp Lys Leu Ser Asp 
    530                 535                 540                 


Tyr Leu Ala Glu His Pro Asp Asp Gly Lys Leu Gly Ser Glu Gly Leu 
545                 550                 555                 560 


Leu Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu Arg Thr Ser 
                565                 570                 575     


Ala Ser Ile Ser Val Phe Arg Val Ala Arg Lys Asp Glu Leu Lys Pro 
            580                 585                 590         


Asn Ser Lys Gly Arg Val Pro Phe Phe Phe Pro Ile Lys Gly Asn Asp 
        595                 600                 605             


Asn Leu Val Ala Val His Glu Arg Ser Gln Leu Leu Lys Leu Pro Gly 
    610                 615                 620                 


Glu Thr Glu Ser Lys Asp Leu Arg Ala Ile Arg Glu Glu Arg Gln Arg 
625                 630                 635                 640 


Thr Leu Arg Gln Leu Arg Thr Gln Leu Ala Tyr Leu Arg Leu Leu Val 
                645                 650                 655     


Arg Cys Gly Ser Glu Asp Val Gly Arg Arg Glu Arg Ser Trp Ala Lys 
            660                 665                 670         


Leu Ile Glu Gln Pro Val Asp Ala Ala Asn His Met Thr Pro Asp Trp 
        675                 680                 685             


Arg Glu Ala Phe Glu Asn Glu Leu Gln Lys Leu Lys Ser Leu His Gly 
    690                 695                 700                 


Ile Cys Ser Asp Lys Glu Trp Met Asp Ala Val Tyr Glu Ser Val Arg 
705                 710                 715                 720 


Arg Val Trp Arg His Met Gly Lys Gln Val Arg Asp Trp Arg Lys Asp 
                725                 730                 735     


Val Arg Ser Gly Glu Arg Pro Lys Ile Arg Gly Tyr Ala Lys Asp Val 
            740                 745                 750         


Val Gly Gly Asn Ser Ile Glu Gln Ile Glu Tyr Leu Glu Arg Gln Tyr 
        755                 760                 765             


Lys Phe Leu Lys Ser Trp Ser Phe Phe Gly Lys Val Ser Gly Gln Val 
    770                 775                 780                 


Ile Arg Ala Glu Lys Gly Ser Arg Phe Ala Ile Thr Leu Arg Glu His 
785                 790                 795                 800 


Ile Asp His Ala Lys Glu Asp Arg Leu Lys Lys Leu Ala Asp Arg Ile 
                805                 810                 815     


Ile Met Glu Ala Leu Gly Tyr Val Tyr Ala Leu Asp Glu Arg Gly Lys 
            820                 825                 830         


Gly Lys Trp Val Ala Lys Tyr Pro Pro Cys Gln Leu Ile Leu Leu Glu 
        835                 840                 845             


Glu Leu Ser Glu Tyr Gln Phe Asn Asn Asp Arg Pro Pro Ser Glu Asn 
    850                 855                 860                 


Asn Gln Leu Met Gln Trp Ser His Arg Gly Val Phe Gln Glu Leu Ile 
865                 870                 875                 880 


Asn Gln Ala Gln Val His Asp Leu Leu Val Gly Thr Met Tyr Ala Ala 
                885                 890                 895     


Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly Ile Arg Cys 
            900                 905                 910         


Arg Arg Val Pro Ala Arg Cys Thr Gln Glu His Asn Pro Glu Pro Phe 
        915                 920                 925             


Pro Trp Trp Leu Asn Lys Phe Val Val Glu His Thr Leu Asp Ala Cys 
    930                 935                 940                 


Pro Leu Arg Ala Asp Asp Leu Ile Pro Thr Gly Glu Gly Glu Ile Phe 
945                 950                 955                 960 


Val Ser Pro Phe Ser Ala Glu Glu Gly Asp Phe His Gln Ile His Ala 
                965                 970                 975     


Asp Leu Asn Ala Ala Gln Asn Leu Gln Gln Arg Leu Trp Ser Asp Phe 
            980                 985                 990         


Asp Ile Ser Gln Ile Arg Leu Arg  Cys Asp Trp Gly Glu  Val Asp Gly 
        995                 1000                 1005             


Glu Leu  Val Leu Ile Pro Arg  Leu Thr Gly Lys Arg  Thr Ala Asp 
    1010                 1015                 1020             


Ser Tyr  Ser Asn Lys Val Phe  Tyr Thr Asn Thr Gly  Val Thr Tyr 
    1025                 1030                 1035             


Tyr Glu  Arg Glu Arg Gly Lys  Lys Arg Arg Lys Val  Phe Ala Gln 
    1040                 1045                 1050             


Glu Lys  Leu Ser Glu Glu Glu  Ala Glu Leu Leu Val  Glu Ala Asp 
    1055                 1060                 1065             


Glu Ala  Arg Glu Lys Ser Val  Val Leu Met Arg Asp  Pro Ser Gly 
    1070                 1075                 1080             


Ile Ile  Asn Arg Gly Asn Trp  Thr Arg Gln Lys Glu  Phe Trp Ser 
    1085                 1090                 1095             


Met Val  Asn Gln Arg Ile Glu  Gly Tyr Leu Val Lys  Gln Ile Arg 
    1100                 1105                 1110             


Ser Arg  Val Pro Leu Gln Asp  Ser Ala Cys Glu Asn  Thr Gly Asp 
    1115                 1120                 1125             


Ile 
    


<210>  315
<211>  872
<212>  PRT
<213>  Alicyclobacillus contaminans

<400>  315

Met Gly Phe Asn Thr Ala Glu Leu Leu Arg Lys Val Glu Glu Glu Met 
1               5                   10                  15      


Arg Lys Thr Ser Val Gly Phe Asp Thr Asp Asn Pro Phe Ala His Arg 
            20                  25                  30          


Ile Thr Arg Arg Ala Ile Arg Gly Trp Asp Arg Ile Ala Glu Ala Trp 
        35                  40                  45              


Arg Arg Leu Pro Pro Asp Ala Pro Glu Ser Glu Tyr Ile Glu Ala Phe 
    50                  55                  60                  


Lys Asp Ile Gln Arg Lys Asn Pro Arg Lys Ile Gly Ser Glu Pro Leu 
65                  70                  75                  80  


Phe Lys Asn Leu Ala Ala Pro Gly Val Arg Ser Glu Leu Leu Asn Asn 
                85                  90                  95      


Pro Gln Val Leu Ile Thr Phe Ala Lys Tyr Asn Glu Leu Gln Arg Gln 
            100                 105                 110         


Leu Ala Lys Ala Lys Gln Phe Ala Gln Lys Thr Leu Pro His Pro Val 
        115                 120                 125             


Phe His Pro Val Trp Val Arg Tyr Asp Lys Leu Gly Gly Asn Leu His 
    130                 135                 140                 


His Tyr Gln Ile Glu Pro Ala Val His Ala Asn Asp Thr His Lys Val 
145                 150                 155                 160 


Lys Phe Ser Ser Leu Leu Leu Pro Gln Glu Asp Gly Ser Tyr Ala Glu 
                165                 170                 175     


Val Lys Asp Val Thr Val Ser Leu Ala Pro Ser Leu Gln Phe Pro Thr 
            180                 185                 190         


Gly Leu Val His Pro Lys Val Thr Thr Pro Pro Arg Thr Gly Leu Val 
        195                 200                 205             


Thr Val Met Asp Glu Glu Ala Gly Lys Pro Val Val Cys Tyr Arg Asp 
    210                 215                 220                 


Arg Gly His Asp Ala Leu Val Pro Val Ala Phe Gly Gly Ala Lys Leu 
225                 230                 235                 240 


Gln Phe Asn Arg Ala His Leu Ser Ala Gly Tyr Arg Lys Gly Val Leu 
                245                 250                 255     


Ser Ala Gly Gly Gly Gly Ser Ile Tyr Phe Asn Val Thr Leu Asp Val 
            260                 265                 270         


Gln Val Pro Asn Glu Arg Asp Val Ser Lys Thr Phe Ser Phe Ser Arg 
        275                 280                 285             


Asp Arg Asp Leu Val Ser Leu Lys Ala Glu Glu Leu Lys Arg Tyr Met 
    290                 295                 300                 


Glu Thr Lys Pro Leu Gly Met Pro Gly Val Arg Val Met Ser Val Asp 
305                 310                 315                 320 


Leu Gly Val Arg Tyr Gly Ala Ala Ile Ser Val Phe Glu Val Lys Pro 
                325                 330                 335     


Phe Ala Glu Val Arg Lys Asp Lys Leu His Tyr Pro Ile Thr Gly Cys 
            340                 345                 350         


Glu Gly Phe Val Ala Glu His Glu Arg Ser Val Ile Leu Lys Leu Pro 
        355                 360                 365             


Gly Glu Gly Val Arg Thr Ala Gly Lys Gln Ser Glu Arg Lys Gln Ala 
    370                 375                 380                 


Leu Ala Ala Ile Arg Ala Glu Met Ser Ile Leu Arg Lys Trp Leu Arg 
385                 390                 395                 400 


Val Ser Gln Val Thr Glu Glu Asp Arg Ala Lys Ala Val Arg Gly Leu 
                405                 410                 415     


Leu Glu Asp Glu Arg Gly Gly Gly Trp Thr Met Asp Pro Gly Glu Asp 
            420                 425                 430         


Ser Asp His Gln Pro Leu Gln Gln Phe Leu His Glu Ala Arg Leu Ala 
        435                 440                 445             


Val Gly Glu Leu Val Asn Leu Val His Leu Ser Pro Ala Glu Trp Glu 
    450                 455                 460                 


Arg Ala Val Ile Glu Arg His Arg Arg Leu Glu Arg Ile Thr Ala Ser 
465                 470                 475                 480 


His Ile Arg Val Phe Gln Thr Met Arg Lys Val Trp Gly Lys Arg Arg 
                485                 490                 495     


Asn Glu Asp Ala Ala His Thr Gly Gly Ile Ser Leu Ala His Ile Glu 
            500                 505                 510         


His Leu Ile Gln Gln Arg Lys Leu Phe Ile Arg Trp Ser Thr His Ala 
        515                 520                 525             


Arg Thr Tyr Gly Glu Val Arg Arg Leu Pro Lys His Glu Gly Phe Ala 
    530                 535                 540                 


Lys Arg Leu Gln Lys His Thr Asn His Val Lys Glu Asp Arg Ile Lys 
545                 550                 555                 560 


Lys Leu Ala Asp Met Ile Val Met Ala Ala Arg Gly Tyr Arg Phe Leu 
                565                 570                 575     


Asp Lys Arg Ala Arg Trp Val Lys Thr Arg His Ala Pro Cys Asp Leu 
            580                 585                 590         


Ile Leu Phe Glu Asp Leu Ser Arg Tyr Arg Phe Thr Met Asp Arg Pro 
        595                 600                 605             


Pro Thr Glu Asn Ser Gln Leu Met Asn Trp Ser His Arg Glu Leu Leu 
    610                 615                 620                 


Lys Thr Val Lys Met Gln Ala Ala Leu Phe Gly Ile Gly Val Gly Thr 
625                 630                 635                 640 


Val Pro Ala Ala Phe Thr Ser Arg Phe Asp Ala Gln Thr Gly Ala Pro 
                645                 650                 655     


Gly Leu Arg Cys Lys Arg Val Thr Lys Gln Asp Lys Glu Lys Thr Pro 
            660                 665                 670         


Phe Trp Leu Ile Gln Phe Ala Glu Ile Thr Gly Val Asn Val Thr Asn 
        675                 680                 685             


Val Glu Pro Gly Gln Leu Ile Pro Val Asp Gly Gly Glu Trp Phe Val 
    690                 695                 700                 


Ser Pro Lys Gly Pro Arg Ala Ala Asp Gly Leu Lys Cys Val His Ala 
705                 710                 715                 720 


Asp Ile Asn Ala Ala His Asn Leu Gln Arg Arg Phe Trp Ile Pro Arg 
                725                 730                 735     


Leu Pro Ser Val Lys Cys Arg Arg Tyr Val Glu Ala Glu Gly Phe Ala 
            740                 745                 750         


Ala Val Pro Ser Ser Thr Ala Phe Met Lys Val His Gly Lys Gly Ala 
        755                 760                 765             


Phe Val Ser Val Asp Gly Glu Phe Tyr Glu Tyr Gln Lys Gly Arg Arg 
    770                 775                 780                 


Val Ala Val Asn Arg Ala Asp Arg Thr Ser Ser Thr Leu Asp Glu Asp 
785                 790                 795                 800 


Glu Gly Asp Ile Gly Glu Glu Met Leu Val Ser Ser Asn Gly Ala Gly 
                805                 810                 815     


Glu Phe Val Arg Met Phe Tyr Asp Glu Ser Gly Tyr Val Gly Tyr Gly 
            820                 825                 830         


Arg Trp Met Asp Ser Lys Val Phe Trp Gly Lys Val Arg Gln Ile Val 
        835                 840                 845             


His Arg Ala Ile Gln Asp Gln Val Glu Lys Arg Ala Ala Ala Arg Gly 
    850                 855                 860                 


Glu Asn Gly Ala Thr Ser Ser Arg 
865                 870         


<210>  316
<211>  1149
<212>  PRT
<213>  Desulfovibrio inopinatus

<400>  316

Met Pro Thr Arg Thr Ile Asn Leu Lys Leu Val Leu Gly Lys Asn Pro 
1               5                   10                  15      


Glu Asn Ala Thr Leu Arg Arg Ala Leu Phe Ser Thr His Arg Leu Val 
            20                  25                  30          


Asn Gln Ala Thr Lys Arg Ile Glu Glu Phe Leu Leu Leu Cys Arg Gly 
        35                  40                  45              


Glu Ala Tyr Arg Thr Val Asp Asn Glu Gly Lys Glu Ala Glu Ile Pro 
    50                  55                  60                  


Arg His Ala Val Gln Glu Glu Ala Leu Ala Phe Ala Lys Ala Ala Gln 
65                  70                  75                  80  


Arg His Asn Gly Cys Ile Ser Thr Tyr Glu Asp Gln Glu Ile Leu Asp 
                85                  90                  95      


Val Leu Arg Gln Leu Tyr Glu Arg Leu Val Pro Ser Val Asn Glu Asn 
            100                 105                 110         


Asn Glu Ala Gly Asp Ala Gln Ala Ala Asn Ala Trp Val Ser Pro Leu 
        115                 120                 125             


Met Ser Ala Glu Ser Glu Gly Gly Leu Ser Val Tyr Asp Lys Val Leu 
    130                 135                 140                 


Asp Pro Pro Pro Val Trp Met Lys Leu Lys Glu Glu Lys Ala Pro Gly 
145                 150                 155                 160 


Trp Glu Ala Ala Ser Gln Ile Trp Ile Gln Ser Asp Glu Gly Gln Ser 
                165                 170                 175     


Leu Leu Asn Lys Pro Gly Ser Pro Pro Arg Trp Ile Arg Lys Leu Arg 
            180                 185                 190         


Ser Gly Gln Pro Trp Gln Asp Asp Phe Val Ser Asp Gln Lys Lys Lys 
        195                 200                 205             


Gln Asp Glu Leu Thr Lys Gly Asn Ala Pro Leu Ile Lys Gln Leu Lys 
    210                 215                 220                 


Glu Met Gly Leu Leu Pro Leu Val Asn Pro Phe Phe Arg His Leu Leu 
225                 230                 235                 240 


Asp Pro Glu Gly Lys Gly Val Ser Pro Trp Asp Arg Leu Ala Val Arg 
                245                 250                 255     


Ala Ala Val Ala His Phe Ile Ser Trp Glu Ser Trp Asn His Arg Thr 
            260                 265                 270         


Arg Ala Glu Tyr Asn Ser Leu Lys Leu Arg Arg Asp Glu Phe Glu Ala 
        275                 280                 285             


Ala Ser Asp Glu Phe Lys Asp Asp Phe Thr Leu Leu Arg Gln Tyr Glu 
    290                 295                 300                 


Ala Lys Arg His Ser Thr Leu Lys Ser Ile Ala Leu Ala Asp Asp Ser 
305                 310                 315                 320 


Asn Pro Tyr Arg Ile Gly Val Arg Ser Leu Arg Ala Trp Asn Arg Val 
                325                 330                 335     


Arg Glu Glu Trp Ile Asp Lys Gly Ala Thr Glu Glu Gln Arg Val Thr 
            340                 345                 350         


Ile Leu Ser Lys Leu Gln Thr Gln Leu Arg Gly Lys Phe Gly Asp Pro 
        355                 360                 365             


Asp Leu Phe Asn Trp Leu Ala Gln Asp Arg His Val His Leu Trp Ser 
    370                 375                 380                 


Pro Arg Asp Ser Val Thr Pro Leu Val Arg Ile Asn Ala Val Asp Lys 
385                 390                 395                 400 


Val Leu Arg Arg Arg Lys Pro Tyr Ala Leu Met Thr Phe Ala His Pro 
                405                 410                 415     


Arg Phe His Pro Arg Trp Ile Leu Tyr Glu Ala Pro Gly Gly Ser Asn 
            420                 425                 430         


Leu Arg Gln Tyr Ala Leu Asp Cys Thr Glu Asn Ala Leu His Ile Thr 
        435                 440                 445             


Leu Pro Leu Leu Val Asp Asp Ala His Gly Thr Trp Ile Glu Lys Lys 
    450                 455                 460                 


Ile Arg Val Pro Leu Ala Pro Ser Gly Gln Ile Gln Asp Leu Thr Leu 
465                 470                 475                 480 


Glu Lys Leu Glu Lys Lys Lys Asn Arg Leu Tyr Tyr Arg Ser Gly Phe 
                485                 490                 495     


Gln Gln Phe Ala Gly Leu Ala Gly Gly Ala Glu Val Leu Phe His Arg 
            500                 505                 510         


Pro Tyr Met Glu His Asp Glu Arg Ser Glu Glu Ser Leu Leu Glu Arg 
        515                 520                 525             


Pro Gly Ala Val Trp Phe Lys Leu Thr Leu Asp Val Ala Thr Gln Ala 
    530                 535                 540                 


Pro Pro Asn Trp Leu Asp Gly Lys Gly Arg Val Arg Thr Pro Pro Glu 
545                 550                 555                 560 


Val His His Phe Lys Thr Ala Leu Ser Asn Lys Ser Lys His Thr Arg 
                565                 570                 575     


Thr Leu Gln Pro Gly Leu Arg Val Leu Ser Val Asp Leu Gly Met Arg 
            580                 585                 590         


Thr Phe Ala Ser Cys Ser Val Phe Glu Leu Ile Glu Gly Lys Pro Glu 
        595                 600                 605             


Thr Gly Arg Ala Phe Pro Val Ala Asp Glu Arg Ser Met Asp Ser Pro 
    610                 615                 620                 


Asn Lys Leu Trp Ala Lys His Glu Arg Ser Phe Lys Leu Thr Leu Pro 
625                 630                 635                 640 


Gly Glu Thr Pro Ser Arg Lys Glu Glu Glu Glu Arg Ser Ile Ala Arg 
                645                 650                 655     


Ala Glu Ile Tyr Ala Leu Lys Arg Asp Ile Gln Arg Leu Lys Ser Leu 
            660                 665                 670         


Leu Arg Leu Gly Glu Glu Asp Asn Asp Asn Arg Arg Asp Ala Leu Leu 
        675                 680                 685             


Glu Gln Phe Phe Lys Gly Trp Gly Glu Glu Asp Val Val Pro Gly Gln 
    690                 695                 700                 


Ala Phe Pro Arg Ser Leu Phe Gln Gly Leu Gly Ala Ala Pro Phe Arg 
705                 710                 715                 720 


Ser Thr Pro Glu Leu Trp Arg Gln His Cys Gln Thr Tyr Tyr Asp Lys 
                725                 730                 735     


Ala Glu Ala Cys Leu Ala Lys His Ile Ser Asp Trp Arg Lys Arg Thr 
            740                 745                 750         


Arg Pro Arg Pro Thr Ser Arg Glu Met Trp Tyr Lys Thr Arg Ser Tyr 
        755                 760                 765             


His Gly Gly Lys Ser Ile Trp Met Leu Glu Tyr Leu Asp Ala Val Arg 
    770                 775                 780                 


Lys Leu Leu Leu Ser Trp Ser Leu Arg Gly Arg Thr Tyr Gly Ala Ile 
785                 790                 795                 800 


Asn Arg Gln Asp Thr Ala Arg Phe Gly Ser Leu Ala Ser Arg Leu Leu 
                805                 810                 815     


His His Ile Asn Ser Leu Lys Glu Asp Arg Ile Lys Thr Gly Ala Asp 
            820                 825                 830         


Ser Ile Val Gln Ala Ala Arg Gly Tyr Ile Pro Leu Pro His Gly Lys 
        835                 840                 845             


Gly Trp Glu Gln Arg Tyr Glu Pro Cys Gln Leu Ile Leu Phe Glu Asp 
    850                 855                 860                 


Leu Ala Arg Tyr Arg Phe Arg Val Asp Arg Pro Arg Arg Glu Asn Ser 
865                 870                 875                 880 


Gln Leu Met Gln Trp Asn His Arg Ala Ile Val Ala Glu Thr Thr Met 
                885                 890                 895     


Gln Ala Glu Leu Tyr Gly Gln Ile Val Glu Asn Thr Ala Ala Gly Phe 
            900                 905                 910         


Ser Ser Arg Phe His Ala Ala Thr Gly Ala Pro Gly Val Arg Cys Arg 
        915                 920                 925             


Phe Leu Leu Glu Arg Asp Phe Asp Asn Asp Leu Pro Lys Pro Tyr Leu 
    930                 935                 940                 


Leu Arg Glu Leu Ser Trp Met Leu Gly Asn Thr Lys Val Glu Ser Glu 
945                 950                 955                 960 


Glu Glu Lys Leu Arg Leu Leu Ser Glu Lys Ile Arg Pro Gly Ser Leu 
                965                 970                 975     


Val Pro Trp Asp Gly Gly Glu Gln Phe Ala Thr Leu His Pro Lys Arg 
            980                 985                 990         


Gln Thr Leu Cys Val Ile His Ala  Asp Met Asn Ala Ala  Gln Asn Leu 
        995                 1000                 1005             


Gln Arg  Arg Phe Phe Gly Arg  Cys Gly Glu Ala Phe  Arg Leu Val 
    1010                 1015                 1020             


Cys Gln  Pro His Gly Asp Asp  Val Leu Arg Leu Ala  Ser Thr Pro 
    1025                 1030                 1035             


Gly Ala  Arg Leu Leu Gly Ala  Leu Gln Gln Leu Glu  Asn Gly Gln 
    1040                 1045                 1050             


Gly Ala  Phe Glu Leu Val Arg  Asp Met Gly Ser Thr  Ser Gln Met 
    1055                 1060                 1065             


Asn Arg  Phe Val Met Lys Ser  Leu Gly Lys Lys Lys  Ile Lys Pro 
    1070                 1075                 1080             


Leu Gln  Asp Asn Asn Gly Asp  Asp Glu Leu Glu Asp  Val Leu Ser 
    1085                 1090                 1095             


Val Leu  Pro Glu Glu Asp Asp  Thr Gly Arg Ile Thr  Val Phe Arg 
    1100                 1105                 1110             


Asp Ser  Ser Gly Ile Phe Phe  Pro Cys Asn Val Trp  Ile Pro Ala 
    1115                 1120                 1125             


Lys Gln  Phe Trp Pro Ala Val  Arg Ala Met Ile Trp  Lys Val Met 
    1130                 1135                 1140             


Ala Ser  His Ser Leu Gly 
    1145                 


<210>  317
<211>  1194
<212>  PRT
<213>  Desulfonatronum thiodismutans

<400>  317

Met Val Leu Gly Arg Lys Asp Asp Thr Ala Glu Leu Arg Arg Ala Leu 
1               5                   10                  15      


Trp Thr Thr His Glu His Val Asn Leu Ala Val Ala Glu Val Glu Arg 
            20                  25                  30          


Val Leu Leu Arg Cys Arg Gly Arg Ser Tyr Trp Thr Leu Asp Arg Arg 
        35                  40                  45              


Gly Asp Pro Val His Val Pro Glu Ser Gln Val Ala Glu Asp Ala Leu 
    50                  55                  60                  


Ala Met Ala Arg Glu Ala Gln Arg Arg Asn Gly Trp Pro Val Val Gly 
65                  70                  75                  80  


Glu Asp Glu Glu Ile Leu Leu Ala Leu Arg Tyr Leu Tyr Glu Gln Ile 
                85                  90                  95      


Val Pro Ser Cys Leu Leu Asp Asp Leu Gly Lys Pro Leu Lys Gly Asp 
            100                 105                 110         


Ala Gln Lys Ile Gly Thr Asn Tyr Ala Gly Pro Leu Phe Asp Ser Asp 
        115                 120                 125             


Thr Cys Arg Arg Asp Glu Gly Lys Asp Val Ala Cys Cys Gly Pro Phe 
    130                 135                 140                 


His Glu Val Ala Gly Lys Tyr Leu Gly Ala Leu Pro Glu Trp Ala Thr 
145                 150                 155                 160 


Pro Ile Ser Lys Gln Glu Phe Asp Gly Lys Asp Ala Ser His Leu Arg 
                165                 170                 175     


Phe Lys Ala Thr Gly Gly Asp Asp Ala Phe Phe Arg Val Ser Ile Glu 
            180                 185                 190         


Lys Ala Asn Ala Trp Tyr Glu Asp Pro Ala Asn Gln Asp Ala Leu Lys 
        195                 200                 205             


Asn Lys Ala Tyr Asn Lys Asp Asp Trp Lys Lys Glu Lys Asp Lys Gly 
    210                 215                 220                 


Ile Ser Ser Trp Ala Val Lys Tyr Ile Gln Lys Gln Leu Gln Leu Gly 
225                 230                 235                 240 


Gln Asp Pro Arg Thr Glu Val Arg Arg Lys Leu Trp Leu Glu Leu Gly 
                245                 250                 255     


Leu Leu Pro Leu Phe Ile Pro Val Phe Asp Lys Thr Met Val Gly Asn 
            260                 265                 270         


Leu Trp Asn Arg Leu Ala Val Arg Leu Ala Leu Ala His Leu Leu Ser 
        275                 280                 285             


Trp Glu Ser Trp Asn His Arg Ala Val Gln Asp Gln Ala Leu Ala Arg 
    290                 295                 300                 


Ala Lys Arg Asp Glu Leu Ala Ala Leu Phe Leu Gly Met Glu Asp Gly 
305                 310                 315                 320 


Phe Ala Gly Leu Arg Glu Tyr Glu Leu Arg Arg Asn Glu Ser Ile Lys 
                325                 330                 335     


Gln His Ala Phe Glu Pro Val Asp Arg Pro Tyr Val Val Ser Gly Arg 
            340                 345                 350         


Ala Leu Arg Ser Trp Thr Arg Val Arg Glu Glu Trp Leu Arg His Gly 
        355                 360                 365             


Asp Thr Gln Glu Ser Arg Lys Asn Ile Cys Asn Arg Leu Gln Asp Arg 
    370                 375                 380                 


Leu Arg Gly Lys Phe Gly Asp Pro Asp Val Phe His Trp Leu Ala Glu 
385                 390                 395                 400 


Asp Gly Gln Glu Ala Leu Trp Lys Glu Arg Asp Cys Val Thr Ser Phe 
                405                 410                 415     


Ser Leu Leu Asn Asp Ala Asp Gly Leu Leu Glu Lys Arg Lys Gly Tyr 
            420                 425                 430         


Ala Leu Met Thr Phe Ala Asp Ala Arg Leu His Pro Arg Trp Ala Met 
        435                 440                 445             


Tyr Glu Ala Pro Gly Gly Ser Asn Leu Arg Thr Tyr Gln Ile Arg Lys 
    450                 455                 460                 


Thr Glu Asn Gly Leu Trp Ala Asp Val Val Leu Leu Ser Pro Arg Asn 
465                 470                 475                 480 


Glu Ser Ala Ala Val Glu Glu Lys Thr Phe Asn Val Arg Leu Ala Pro 
                485                 490                 495     


Ser Gly Gln Leu Ser Asn Val Ser Phe Asp Gln Ile Gln Lys Gly Ser 
            500                 505                 510         


Lys Met Val Gly Arg Cys Arg Tyr Gln Ser Ala Asn Gln Gln Phe Glu 
        515                 520                 525             


Gly Leu Leu Gly Gly Ala Glu Ile Leu Phe Asp Arg Lys Arg Ile Ala 
    530                 535                 540                 


Asn Glu Gln His Gly Ala Thr Asp Leu Ala Ser Lys Pro Gly His Val 
545                 550                 555                 560 


Trp Phe Lys Leu Thr Leu Asp Val Arg Pro Gln Ala Pro Gln Gly Trp 
                565                 570                 575     


Leu Asp Gly Lys Gly Arg Pro Ala Leu Pro Pro Glu Ala Lys His Phe 
            580                 585                 590         


Lys Thr Ala Leu Ser Asn Lys Ser Lys Phe Ala Asp Gln Val Arg Pro 
        595                 600                 605             


Gly Leu Arg Val Leu Ser Val Asp Leu Gly Val Arg Ser Phe Ala Ala 
    610                 615                 620                 


Cys Ser Val Phe Glu Leu Val Arg Gly Gly Pro Asp Gln Gly Thr Tyr 
625                 630                 635                 640 


Phe Pro Ala Ala Asp Gly Arg Thr Val Asp Asp Pro Glu Lys Leu Trp 
                645                 650                 655     


Ala Lys His Glu Arg Ser Phe Lys Ile Thr Leu Pro Gly Glu Asn Pro 
            660                 665                 670         


Ser Arg Lys Glu Glu Ile Ala Arg Arg Ala Ala Met Glu Glu Leu Arg 
        675                 680                 685             


Ser Leu Asn Gly Asp Ile Arg Arg Leu Lys Ala Ile Leu Arg Leu Ser 
    690                 695                 700                 


Val Leu Gln Glu Asp Asp Pro Arg Thr Glu His Leu Arg Leu Phe Met 
705                 710                 715                 720 


Glu Ala Ile Val Asp Asp Pro Ala Lys Ser Ala Leu Asn Ala Glu Leu 
                725                 730                 735     


Phe Lys Gly Phe Gly Asp Asp Arg Phe Arg Ser Thr Pro Asp Leu Trp 
            740                 745                 750         


Lys Gln His Cys His Phe Phe His Asp Lys Ala Glu Lys Val Val Ala 
        755                 760                 765             


Glu Arg Phe Ser Arg Trp Arg Thr Glu Thr Arg Pro Lys Ser Ser Ser 
    770                 775                 780                 


Trp Gln Asp Trp Arg Glu Arg Arg Gly Tyr Ala Gly Gly Lys Ser Tyr 
785                 790                 795                 800 


Trp Ala Val Thr Tyr Leu Glu Ala Val Arg Gly Leu Ile Leu Arg Trp 
                805                 810                 815     


Asn Met Arg Gly Arg Thr Tyr Gly Glu Val Asn Arg Gln Asp Lys Lys 
            820                 825                 830         


Gln Phe Gly Thr Val Ala Ser Ala Leu Leu His His Ile Asn Gln Leu 
        835                 840                 845             


Lys Glu Asp Arg Ile Lys Thr Gly Ala Asp Met Ile Ile Gln Ala Ala 
    850                 855                 860                 


Arg Gly Phe Val Pro Arg Lys Asn Gly Ala Gly Trp Val Gln Val His 
865                 870                 875                 880 


Glu Pro Cys Arg Leu Ile Leu Phe Glu Asp Leu Ala Arg Tyr Arg Phe 
                885                 890                 895     


Arg Thr Asp Arg Ser Arg Arg Glu Asn Ser Arg Leu Met Arg Trp Ser 
            900                 905                 910         


His Arg Glu Ile Val Asn Glu Val Gly Met Gln Gly Glu Leu Tyr Gly 
        915                 920                 925             


Leu His Val Asp Thr Thr Glu Ala Gly Phe Ser Ser Arg Tyr Leu Ala 
    930                 935                 940                 


Ser Ser Gly Ala Pro Gly Val Arg Cys Arg His Leu Val Glu Glu Asp 
945                 950                 955                 960 


Phe His Asp Gly Leu Pro Gly Met His Leu Val Gly Glu Leu Asp Trp 
                965                 970                 975     


Leu Leu Pro Lys Asp Lys Asp Arg Thr Ala Asn Glu Ala Arg Arg Leu 
            980                 985                 990         


Leu Gly Gly Met Val Arg Pro Gly  Met Leu Val Pro Trp  Asp Gly Gly 
        995                 1000                 1005             


Glu Leu  Phe Ala Thr Leu Asn  Ala Ala Ser Gln Leu  His Val Ile 
    1010                 1015                 1020             


His Ala  Asp Ile Asn Ala Ala  Gln Asn Leu Gln Arg  Arg Phe Trp 
    1025                 1030                 1035             


Gly Arg  Cys Gly Glu Ala Ile  Arg Ile Val Cys Asn  Gln Leu Ser 
    1040                 1045                 1050             


Val Asp  Gly Ser Thr Arg Tyr  Glu Met Ala Lys Ala  Pro Lys Ala 
    1055                 1060                 1065             


Arg Leu  Leu Gly Ala Leu Gln  Gln Leu Lys Asn Gly  Asp Ala Pro 
    1070                 1075                 1080             


Phe His  Leu Thr Ser Ile Pro  Asn Ser Gln Lys Pro  Glu Asn Ser 
    1085                 1090                 1095             


Tyr Val  Met Thr Pro Thr Asn  Ala Gly Lys Lys Tyr  Arg Ala Gly 
    1100                 1105                 1110             


Pro Gly  Glu Lys Ser Ser Gly  Glu Glu Asp Glu Leu  Ala Leu Asp 
    1115                 1120                 1125             


Ile Val  Glu Gln Ala Glu Glu  Leu Ala Gln Gly Arg  Lys Thr Phe 
    1130                 1135                 1140             


Phe Arg  Asp Pro Ser Gly Val  Phe Phe Ala Pro Asp  Arg Trp Leu 
    1145                 1150                 1155             


Pro Ser  Glu Ile Tyr Trp Ser  Arg Ile Arg Arg Arg  Ile Trp Gln 
    1160                 1165                 1170             


Val Thr  Leu Glu Arg Asn Ser  Ser Gly Arg Gln Glu  Arg Ala Glu 
    1175                 1180                 1185             


Met Asp  Glu Met Pro Tyr 
    1190                 


<210>  318
<211>  1132
<212>  PRT
<213>  Tuberibacillus calidus

<400>  318

Met Ala Thr Lys Ser Phe Ile Leu Lys Met Lys Thr Lys Asn Asn Pro 
1               5                   10                  15      


Gln Leu Arg Leu Ser Leu Trp Lys Thr His Glu Leu Phe Asn Phe Gly 
            20                  25                  30          


Val Ala Tyr Tyr Met Asp Leu Leu Ser Leu Phe Arg Gln Lys Asp Leu 
        35                  40                  45              


Tyr Met His Asn Asp Glu Asp Pro Asp His Pro Val Val Leu Lys Lys 
    50                  55                  60                  


Glu Glu Ile Gln Glu Arg Leu Trp Met Lys Val Arg Glu Thr Gln Gln 
65                  70                  75                  80  


Lys Asn Gly Phe His Gly Glu Val Ser Lys Asp Glu Val Leu Glu Thr 
                85                  90                  95      


Leu Arg Ala Leu Tyr Glu Glu Leu Val Pro Ser Ala Val Gly Lys Ser 
            100                 105                 110         


Gly Glu Ala Asn Gln Ile Ser Asn Lys Tyr Leu Tyr Pro Leu Thr Asp 
        115                 120                 125             


Pro Ala Ser Gln Ser Gly Lys Gly Thr Ala Asn Ser Gly Arg Lys Pro 
    130                 135                 140                 


Arg Trp Lys Lys Leu Lys Glu Ala Gly Asp Pro Ser Trp Lys Asp Ala 
145                 150                 155                 160 


Tyr Glu Lys Trp Glu Lys Glu Arg Gln Glu Asp Pro Lys Leu Lys Ile 
                165                 170                 175     


Leu Ala Ala Leu Gln Ser Phe Gly Leu Ile Pro Leu Phe Arg Pro Phe 
            180                 185                 190         


Thr Glu Asn Asp His Lys Ala Val Ile Ser Val Lys Trp Met Pro Lys 
        195                 200                 205             


Ser Lys Asn Gln Ser Val Arg Lys Phe Asp Lys Asp Met Phe Asn Gln 
    210                 215                 220                 


Ala Ile Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Glu Lys Val Ala 
225                 230                 235                 240 


Glu Asp Tyr Glu Lys Thr Val Ser Ile Tyr Glu Ser Leu Gln Lys Glu 
                245                 250                 255     


Leu Lys Gly Ile Ser Thr Lys Ala Phe Glu Ile Met Glu Arg Val Glu 
            260                 265                 270         


Lys Ala Tyr Glu Ala His Leu Arg Glu Ile Thr Phe Ser Asn Ser Thr 
        275                 280                 285             


Tyr Arg Ile Gly Asn Arg Ala Ile Arg Gly Trp Thr Glu Ile Val Lys 
    290                 295                 300                 


Lys Trp Met Lys Leu Asp Pro Ser Ala Pro Gln Gly Asn Tyr Leu Asp 
305                 310                 315                 320 


Val Val Lys Asp Tyr Gln Arg Arg His Pro Arg Glu Ser Gly Asp Phe 
                325                 330                 335     


Lys Leu Phe Glu Leu Leu Ser Arg Pro Glu Asn Gln Ala Ala Trp Arg 
            340                 345                 350         


Glu Tyr Pro Glu Phe Leu Pro Leu Tyr Val Lys Tyr Arg His Ala Glu 
        355                 360                 365             


Gln Arg Met Lys Thr Ala Lys Lys Gln Ala Thr Phe Thr Leu Cys Asp 
    370                 375                 380                 


Pro Ile Arg His Pro Leu Trp Val Arg Tyr Glu Glu Arg Ser Gly Thr 
385                 390                 395                 400 


Asn Leu Asn Lys Tyr Arg Leu Ile Met Asn Glu Lys Glu Lys Val Val 
                405                 410                 415     


Gln Phe Asp Arg Leu Ile Cys Leu Asn Ala Asp Gly His Tyr Glu Glu 
            420                 425                 430         


Gln Glu Asp Val Thr Val Pro Leu Ala Pro Ser Gln Gln Phe Asp Asp 
        435                 440                 445             


Gln Ile Lys Phe Ser Ser Glu Asp Thr Gly Lys Gly Lys His Asn Phe 
    450                 455                 460                 


Ser Tyr Tyr His Lys Gly Ile Asn Tyr Glu Leu Lys Gly Thr Leu Gly 
465                 470                 475                 480 


Gly Ala Arg Ile Gln Phe Asp Arg Glu His Leu Leu Arg Arg Gln Gly 
                485                 490                 495     


Val Lys Ala Gly Asn Val Gly Arg Ile Phe Leu Asn Val Thr Leu Asn 
            500                 505                 510         


Ile Glu Pro Met Gln Pro Phe Ser Arg Ser Gly Asn Leu Gln Thr Ser 
        515                 520                 525             


Val Gly Lys Ala Leu Lys Val Tyr Val Asp Gly Tyr Pro Lys Val Val 
    530                 535                 540                 


Asn Phe Lys Pro Lys Glu Leu Thr Glu His Ile Lys Glu Ser Glu Lys 
545                 550                 555                 560 


Asn Thr Leu Thr Leu Gly Val Glu Ser Leu Pro Thr Gly Leu Arg Val 
                565                 570                 575     


Met Ser Val Asp Leu Gly Gln Arg Gln Ala Ala Ala Ile Ser Ile Phe 
            580                 585                 590         


Glu Val Val Ser Glu Lys Pro Asp Asp Asn Lys Leu Phe Tyr Pro Val 
        595                 600                 605             


Lys Asp Thr Asp Leu Phe Ala Val His Arg Thr Ser Phe Asn Ile Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Arg Thr Glu Arg Arg Met Leu Glu Gln Gln Lys 
625                 630                 635                 640 


Arg Asp Gln Ala Ile Arg Asp Leu Ser Arg Lys Leu Lys Phe Leu Lys 
                645                 650                 655     


Asn Val Leu Asn Met Gln Lys Leu Glu Lys Thr Asp Glu Arg Glu Lys 
            660                 665                 670         


Arg Val Asn Arg Trp Ile Lys Asp Arg Glu Arg Glu Glu Glu Asn Pro 
        675                 680                 685             


Val Tyr Val Gln Glu Phe Glu Met Ile Ser Lys Val Leu Tyr Ser Pro 
    690                 695                 700                 


His Ser Val Trp Val Asp Gln Leu Lys Ser Ile His Arg Lys Leu Glu 
705                 710                 715                 720 


Glu Gln Leu Gly Lys Glu Ile Ser Lys Trp Arg Gln Ser Ile Ser Gln 
                725                 730                 735     


Gly Arg Gln Gly Val Tyr Gly Ile Ser Leu Lys Asn Ile Glu Asp Ile 
            740                 745                 750         


Glu Lys Thr Arg Arg Leu Leu Phe Arg Trp Ser Met Arg Pro Glu Asn 
        755                 760                 765             


Pro Gly Glu Val Lys Gln Leu Gln Pro Gly Glu Arg Phe Ala Ile Asp 
    770                 775                 780                 


Gln Gln Asn His Leu Asn His Leu Lys Asp Asp Arg Ile Lys Lys Leu 
785                 790                 795                 800 


Ala Asn Gln Ile Val Met Thr Ala Leu Gly Tyr Arg Tyr Asp Gly Lys 
                805                 810                 815     


Arg Lys Lys Trp Ile Ala Lys His Pro Ala Cys Gln Leu Val Leu Phe 
            820                 825                 830         


Glu Asp Leu Ser Arg Tyr Ala Phe Tyr Asp Glu Arg Ser Arg Leu Glu 
        835                 840                 845             


Asn Arg Asn Leu Met Arg Trp Ser Arg Arg Glu Ile Pro Lys Gln Val 
    850                 855                 860                 


Ala Gln Ile Gly Gly Leu Tyr Gly Leu Leu Val Gly Glu Val Gly Ala 
865                 870                 875                 880 


Gln Tyr Ser Ser Arg Phe His Ala Lys Ser Gly Ala Pro Gly Ile Arg 
                885                 890                 895     


Cys Arg Val Val Lys Glu His Glu Leu Tyr Ile Thr Glu Gly Gly Gln 
            900                 905                 910         


Lys Val Arg Asn Gln Lys Phe Leu Asp Ser Leu Val Glu Asn Asn Ile 
        915                 920                 925             


Ile Glu Pro Asp Asp Ala Arg Arg Leu Glu Pro Gly Asp Leu Ile Arg 
    930                 935                 940                 


Asp Gln Gly Gly Asp Lys Phe Ala Thr Leu Asp Glu Arg Gly Glu Leu 
945                 950                 955                 960 


Val Ile Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln Lys Arg 
                965                 970                 975     


Phe Trp Thr Arg Thr His Gly Leu Tyr Arg Ile Arg Cys Glu Ser Arg 
            980                 985                 990         


Glu Ile Lys Asp Ala Val Val Leu  Val Pro Ser Asp Lys  Asp Gln Lys 
        995                 1000                 1005             


Glu Lys  Met Glu Asn Leu Phe  Gly Ile Gly Tyr Leu  Gln Pro Phe 
    1010                 1015                 1020             


Lys Gln  Glu Asn Asp Val Tyr  Lys Trp Val Lys Gly  Glu Lys Ile 
    1025                 1030                 1035             


Lys Gly  Lys Lys Thr Ser Ser  Gln Ser Asp Asp Lys  Glu Leu Val 
    1040                 1045                 1050             


Ser Glu  Ile Leu Gln Glu Ala  Ser Val Met Ala Asp  Glu Leu Lys 
    1055                 1060                 1065             


Gly Asn  Arg Lys Thr Leu Phe  Arg Asp Pro Ser Gly  Tyr Val Phe 
    1070                 1075                 1080             


Pro Lys  Asp Arg Trp Tyr Thr  Gly Gly Arg Tyr Phe  Gly Thr Leu 
    1085                 1090                 1095             


Glu His  Leu Leu Lys Arg Lys  Leu Ala Glu Arg Arg  Leu Phe Asp 
    1100                 1105                 1110             


Gly Gly  Ser Ser Arg Arg Gly  Leu Phe Asn Gly Thr  Asp Ser Asn 
    1115                 1120                 1125             


Thr Asn  Val Glu 
    1130         


<210>  319
<211>  1108
<212>  PRT
<213>  Bacillus thermoamylovorans

<400>  319

Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Val Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Phe Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu His Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Phe Lys Ser Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Phe Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Leu Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Gly Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210>  320
<211>  1108
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  320

Met Ala Ile Arg Ser Ile Lys Leu Lys Leu Lys Thr His Thr Gly Pro 
1               5                   10                  15      


Glu Ala Gln Asn Leu Arg Lys Gly Ile Trp Arg Thr His Arg Leu Leu 
            20                  25                  30          


Asn Glu Gly Val Ala Tyr Tyr Met Lys Met Leu Leu Leu Phe Arg Gln 
        35                  40                  45              


Glu Ser Thr Gly Glu Arg Pro Lys Glu Glu Leu Gln Glu Glu Leu Ile 
    50                  55                  60                  


Cys His Ile Arg Glu Gln Gln Gln Arg Asn Gln Ala Asp Lys Asn Thr 
65                  70                  75                  80  


Gln Ala Leu Pro Leu Asp Lys Ala Leu Glu Ala Leu Arg Gln Leu Tyr 
                85                  90                  95      


Glu Leu Leu Val Pro Ser Ser Val Gly Gln Ser Gly Asp Ala Gln Ile 
            100                 105                 110         


Ile Ser Arg Lys Phe Leu Ser Pro Leu Val Asp Pro Asn Ser Glu Gly 
        115                 120                 125             


Gly Lys Gly Thr Ser Lys Ala Gly Ala Lys Pro Thr Trp Gln Lys Lys 
    130                 135                 140                 


Lys Glu Ala Asn Asp Pro Thr Trp Glu Gln Asp Tyr Glu Lys Trp Lys 
145                 150                 155                 160 


Lys Arg Arg Glu Glu Asp Pro Thr Ala Ser Val Ile Thr Thr Leu Glu 
                165                 170                 175     


Glu Tyr Gly Ile Arg Pro Ile Phe Pro Leu Tyr Thr Asn Thr Val Thr 
            180                 185                 190         


Asp Ile Ala Trp Leu Pro Leu Gln Ser Asn Gln Phe Val Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Leu Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Lys Arg Val Gln Glu Glu Tyr Ala Lys Leu Lys Glu Lys 
225                 230                 235                 240 


Met Ala Gln Leu Asn Glu Gln Leu Glu Gly Gly Gln Glu Trp Ile Ser 
                245                 250                 255     


Leu Leu Glu Gln Tyr Glu Glu Asn Arg Glu Arg Glu Leu Arg Glu Asn 
            260                 265                 270         


Met Thr Ala Ala Asn Asp Lys Tyr Arg Ile Thr Lys Arg Gln Met Lys 
        275                 280                 285             


Gly Trp Asn Glu Leu Tyr Glu Leu Trp Ser Thr Phe Pro Ala Ser Ala 
    290                 295                 300                 


Ser His Glu Gln Tyr Lys Glu Ala Leu Lys Arg Val Gln Gln Arg Leu 
305                 310                 315                 320 


Arg Gly Arg Phe Gly Asp Ala His Phe Phe Gln Tyr Leu Met Glu Glu 
                325                 330                 335     


Lys Asn Arg Leu Ile Trp Lys Gly Asn Pro Gln Arg Ile His Tyr Phe 
            340                 345                 350         


Val Ala Arg Asn Glu Leu Thr Lys Arg Leu Glu Glu Ala Lys Gln Ser 
        355                 360                 365             


Ala Thr Met Thr Leu Pro Asn Ala Arg Lys His Pro Leu Trp Val Arg 
    370                 375                 380                 


Phe Asp Ala Arg Gly Gly Asn Leu Gln Asp Tyr Tyr Leu Thr Ala Glu 
385                 390                 395                 400 


Ala Asp Lys Pro Arg Ser Arg Arg Phe Val Thr Phe Ser Gln Leu Ile 
                405                 410                 415     


Trp Pro Ser Glu Ser Gly Trp Met Glu Lys Lys Asp Val Glu Val Glu 
            420                 425                 430         


Leu Ala Leu Ser Arg Gln Phe Tyr Gln Gln Val Lys Leu Leu Lys Asn 
        435                 440                 445             


Asp Lys Gly Lys Gln Lys Ile Glu Phe Lys Asp Lys Gly Ser Gly Ser 
    450                 455                 460                 


Thr Phe Asn Gly His Leu Gly Gly Ala Lys Leu Gln Leu Glu Arg Gly 
465                 470                 475                 480 


Asp Leu Glu Lys Glu Glu Lys Asn Phe Glu Asp Gly Glu Ile Gly Ser 
                485                 490                 495     


Val Tyr Leu Asn Val Val Ile Asp Phe Glu Pro Leu Gln Glu Val Lys 
            500                 505                 510         


Asn Gly Arg Val Gln Ala Pro Tyr Gly Gln Val Leu Gln Leu Ile Arg 
        515                 520                 525             


Arg Pro Asn Glu Phe Pro Lys Val Thr Thr Tyr Lys Ser Glu Gln Leu 
    530                 535                 540                 


Val Glu Trp Ile Lys Ala Ser Pro Gln His Ser Ala Gly Val Glu Ser 
545                 550                 555                 560 


Leu Ala Ser Gly Phe Arg Val Met Ser Ile Asp Leu Gly Leu Arg Ala 
                565                 570                 575     


Ala Ala Ala Thr Ser Ile Phe Ser Val Glu Glu Ser Ser Asp Lys Asn 
            580                 585                 590         


Ala Ala Asp Phe Ser Tyr Trp Ile Glu Gly Thr Pro Leu Val Ala Val 
        595                 600                 605             


His Gln Arg Ser Tyr Met Leu Arg Leu Pro Gly Glu Gln Val Glu Lys 
    610                 615                 620                 


Gln Val Met Glu Lys Arg Asp Glu Arg Phe Gln Leu His Gln Arg Val 
625                 630                 635                 640 


Lys Phe Gln Ile Arg Val Leu Ala Gln Ile Met Arg Met Ala Asn Lys 
                645                 650                 655     


Gln Tyr Gly Asp Arg Trp Asp Glu Leu Asp Ser Leu Lys Gln Ala Val 
            660                 665                 670         


Glu Gln Lys Lys Ser Pro Leu Asp Gln Thr Asp Arg Thr Phe Trp Glu 
        675                 680                 685             


Gly Ile Val Cys Asp Leu Thr Lys Val Leu Pro Arg Asn Glu Ala Asp 
    690                 695                 700                 


Trp Glu Gln Ala Val Val Gln Ile His Arg Lys Ala Glu Glu Tyr Val 
705                 710                 715                 720 


Gly Lys Ala Val Gln Ala Trp Arg Lys Arg Phe Ala Ala Asp Glu Arg 
                725                 730                 735     


Lys Gly Ile Ala Gly Leu Ser Met Trp Asn Ile Glu Glu Leu Glu Gly 
            740                 745                 750         


Leu Arg Lys Leu Leu Ile Ser Trp Ser Arg Arg Thr Arg Asn Pro Gln 
        755                 760                 765             


Glu Val Asn Arg Phe Glu Arg Gly His Thr Ser His Gln Arg Leu Leu 
    770                 775                 780                 


Thr His Ile Gln Asn Val Lys Glu Asp Arg Leu Lys Gln Leu Ser His 
785                 790                 795                 800 


Ala Ile Val Met Thr Ala Leu Gly Tyr Val Tyr Asp Glu Arg Lys Gln 
                805                 810                 815     


Glu Trp Cys Ala Glu Tyr Pro Ala Cys Gln Val Ile Leu Phe Glu Asn 
            820                 825                 830         


Leu Ser Gln Tyr Arg Ser Asn Leu Asp Arg Ser Thr Lys Glu Asn Ser 
        835                 840                 845             


Thr Leu Met Lys Trp Ala His Arg Ser Ile Pro Lys Tyr Val His Met 
    850                 855                 860                 


Gln Ala Glu Pro Tyr Gly Ile Gln Ile Gly Asp Val Arg Ala Glu Tyr 
865                 870                 875                 880 


Ser Ser Arg Phe Tyr Ala Lys Thr Gly Thr Pro Gly Ile Arg Cys Lys 
                885                 890                 895     


Lys Val Arg Gly Gln Asp Leu Gln Gly Arg Arg Phe Glu Asn Leu Gln 
            900                 905                 910         


Lys Arg Leu Val Asn Glu Gln Phe Leu Thr Glu Glu Gln Val Lys Gln 
        915                 920                 925             


Leu Arg Pro Gly Asp Ile Val Pro Asp Asp Ser Gly Glu Leu Phe Met 
    930                 935                 940                 


Thr Leu Thr Asp Gly Ser Gly Ser Lys Glu Val Val Phe Leu Gln Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala His Asn Leu Gln Lys Arg Phe Trp Gln Arg Tyr 
                965                 970                 975     


Asn Glu Leu Phe Lys Val Ser Cys Arg Val Ile Val Arg Asp Glu Glu 
            980                 985                 990         


Glu Tyr Leu Val Pro Lys Thr Lys  Ser Val Gln Ala Lys  Leu Gly Lys 
        995                 1000                 1005             


Gly Leu  Phe Val Lys Lys Ser  Asp Thr Ala Trp Lys  Asp Val Tyr 
    1010                 1015                 1020             


Val Trp  Asp Ser Gln Ala Lys  Leu Lys Gly Lys Thr  Thr Phe Thr 
    1025                 1030                 1035             


Glu Glu  Ser Glu Ser Pro Glu  Gln Leu Glu Asp Phe  Gln Glu Ile 
    1040                 1045                 1050             


Ile Glu  Glu Ala Glu Glu Ala  Lys Gly Thr Tyr Arg  Thr Leu Phe 
    1055                 1060                 1065             


Arg Asp  Pro Ser Gly Val Phe  Phe Pro Glu Ser Val  Trp Tyr Pro 
    1070                 1075                 1080             


Gln Lys  Asp Phe Trp Gly Glu  Val Lys Arg Lys Leu  Tyr Gly Lys 
    1085                 1090                 1095             


Leu Arg  Glu Arg Phe Leu Thr  Lys Ala Arg 
    1100                 1105             


<210>  321
<211>  658
<212>  PRT
<213>  Methylobacterium nodulans

<400>  321

Met Leu Thr Lys Gln Asp Lys Gln Gln Lys Ile Thr Tyr Cys Thr Asn 
1               5                   10                  15      


Met Asn Glu Val Phe Glu Ala Lys Leu Gly Ser Ala Asp Leu Leu Leu 
            20                  25                  30          


Asn Trp Asp His Leu Arg Gly Arg Ile Arg Asp Arg Val Asp Ala Gly 
        35                  40                  45              


Asp Ile Gly Ser Ala Phe Leu Lys Leu Ala Leu Asp Val Ala His Val 
    50                  55                  60                  


Leu Pro Asp Gly Val Asp Asp Gln Leu Ala Arg Ala Ala Phe His Phe 
65                  70                  75                  80  


Gln Ser Ala Lys Gly Ala Lys Ser Lys His Ala Asp Ser Val Gln Ala 
                85                  90                  95      


Gly Leu Arg Val Leu Ser Ile Asp Leu Gly Val Arg Ser Phe Ala Thr 
            100                 105                 110         


Cys Ser Val Phe Glu Leu Lys Asp Thr Ala Pro Thr Thr Gly Val Ala 
        115                 120                 125             


Phe Pro Leu Ala Glu Phe Arg Leu Trp Ala Val His Glu Arg Ser Phe 
    130                 135                 140                 


Thr Leu Glu Leu Pro Gly Glu Asn Val Gly Ala Ala Gly Gln Gln Trp 
145                 150                 155                 160 


Arg Ala Gln Ala Asp Ala Glu Leu Arg Gln Leu Arg Gly Gly Leu Asn 
                165                 170                 175     


Arg His Arg Gln Leu Leu Arg Ala Ala Thr Val Gln Lys Gly Glu Arg 
            180                 185                 190         


Asp Ala Tyr Leu Thr Asp Leu Arg Glu Ala Trp Ser Ala Lys Glu Leu 
        195                 200                 205             


Trp Pro Phe Glu Ala Ser Leu Leu Ser Glu Leu Glu Arg Cys Ser Thr 
    210                 215                 220                 


Val Ala Asp Pro Leu Trp Gln Asp Thr Cys Lys Arg Ala Ala Arg Leu 
225                 230                 235                 240 


Tyr Arg Thr Glu Phe Gly Ala Val Val Ser Glu Trp Arg Ser Arg Thr 
                245                 250                 255     


Arg Ser Arg Glu Asp Arg Lys Tyr Ala Gly Lys Ser Met Trp Ser Val 
            260                 265                 270         


Gln His Leu Thr Asp Val Arg Arg Phe Leu Gln Ser Trp Ser Leu Ala 
        275                 280                 285             


Gly Arg Ala Ser Gly Asp Ile Arg Arg Leu Asp Arg Glu Arg Gly Gly 
    290                 295                 300                 


Val Phe Ala Lys Asp Leu Leu Asp His Ile Asp Ala Leu Lys Asp Asp 
305                 310                 315                 320 


Arg Leu Lys Thr Gly Ala Asp Leu Ile Val Gln Ala Ala Arg Gly Phe 
                325                 330                 335     


Gln Arg Asn Glu Phe Gly Tyr Trp Val Gln Lys His Ala Pro Cys His 
            340                 345                 350         


Val Ile Leu Phe Glu Asp Leu Ser Arg Tyr Arg Met Arg Thr Asp Arg 
        355                 360                 365             


Pro Arg Arg Glu Asn Ser Gln Leu Met Gln Trp Ala His Arg Gly Val 
    370                 375                 380                 


Pro Asp Met Val Gly Met Gln Gly Glu Ile Tyr Gly Ile Gln Asp Arg 
385                 390                 395                 400 


Arg Asp Pro Asp Ser Ala Arg Lys His Ala Arg Gln Pro Leu Ala Ala 
                405                 410                 415     


Phe Cys Leu Asp Thr Pro Ala Ala Phe Ser Ser Arg Tyr His Ala Ser 
            420                 425                 430         


Thr Met Thr Pro Gly Ile Arg Cys His Pro Leu Arg Lys Arg Glu Phe 
        435                 440                 445             


Glu Asp Gln Gly Phe Leu Glu Leu Leu Lys Arg Glu Asn Glu Gly Leu 
    450                 455                 460                 


Asp Leu Asn Gly Tyr Lys Pro Gly Asp Leu Val Pro Leu Pro Gly Gly 
465                 470                 475                 480 


Glu Val Phe Val Cys Leu Asn Ala Asn Gly Leu Ser Arg Ile His Ala 
                485                 490                 495     


Asp Ile Asn Ala Ala Gln Asn Leu Gln Arg Arg Phe Trp Thr Gln His 
            500                 505                 510         


Gly Asp Ala Phe Arg Leu Pro Cys Gly Lys Ser Ala Val Gln Gly Gln 
        515                 520                 525             


Ile Arg Trp Ala Pro Leu Ser Met Gly Lys Arg Gln Ala Gly Ala Leu 
    530                 535                 540                 


Gly Gly Phe Gly Tyr Leu Glu Pro Thr Gly His Asp Ser Gly Ser Cys 
545                 550                 555                 560 


Gln Trp Arg Lys Thr Thr Glu Ala Glu Trp Arg Arg Leu Ser Gly Ala 
                565                 570                 575     


Gln Lys Asp Arg Asp Glu Ala Ala Ala Ala Glu Asp Glu Glu Leu Gln 
            580                 585                 590         


Gly Leu Glu Glu Glu Leu Leu Glu Arg Ser Gly Glu Arg Val Val Phe 
        595                 600                 605             


Phe Arg Asp Pro Ser Gly Val Val Leu Pro Thr Asp Leu Trp Phe Pro 
    610                 615                 620                 


Ser Ala Ala Phe Trp Ser Ile Val Arg Ala Lys Thr Val Gly Arg Leu 
625                 630                 635                 640 


Arg Ser His Leu Asp Ala Gln Ala Glu Ala Ser Tyr Ala Val Ala Ala 
                645                 650                 655     


Gly Leu 
        


<210>  322
<211>  1302
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  322

Met Lys Lys Phe Glu Leu Lys Gln Asn Phe Arg Asn Asn Tyr Ser Gly 
1               5                   10                  15      


Lys Thr Leu Arg Asn Phe Arg Gln Thr Leu Ala Gln Ile Ala Asn Lys 
            20                  25                  30          


Lys Ser Ser Asp Ser Ile Leu Thr Ile Lys Phe Lys Leu Asp Cys Ser 
        35                  40                  45              


Lys Thr Gly Lys Leu Pro Lys Tyr Glu Asn Leu Ile Ser Leu Tyr Asp 
    50                  55                  60                  


Thr Ile Glu Asp Ile Lys Lys Gly Thr Leu Ser Tyr Tyr Leu Phe Thr 
65                  70                  75                  80  


Leu Ile Val Ser Gly Phe Lys Phe Phe Gly Ser Ala Ser Gln Ala Lys 
                85                  90                  95      


Ala Phe Ser Thr Lys Asp Ile Phe Lys Asp Asn Asp Phe Tyr Asn Gln 
            100                 105                 110         


Phe Lys Ile Gln Ser His Leu Asp Leu Pro Asp Phe Val Pro Ser Lys 
        115                 120                 125             


Ile Tyr Gln Arg Leu Lys Lys Asn Val Arg Ser Thr Asn Gly Lys Asp 
    130                 135                 140                 


Asn Ala Phe Lys Ala Ser Val Ile Val Ala Glu Tyr Arg Lys Glu Ile 
145                 150                 155                 160 


Gly Lys Leu Lys Asn Lys Asp Glu Ser Ser Glu His Gln Cys Glu Glu 
                165                 170                 175     


Leu Phe Lys Lys Ile Gly Thr Ala Leu Glu Thr Arg Phe Ser Ser Trp 
            180                 185                 190         


Gln Asp Leu Ile Asn Asn Cys Ser Thr Gly Cys Glu Ile Ile Asp Glu 
        195                 200                 205             


Ile Leu Asn Asp Ser Phe Gly Thr Leu Pro Ser Ile Lys Lys Met Val 
    210                 215                 220                 


Leu Ala Ser Thr Thr Gln Ser Ser Asp Gly Glu Gln Asp Gly Ile Ala 
225                 230                 235                 240 


Ile Ala Tyr Asp Pro Asp Ser Thr Phe Ile Lys Ser Asp Glu Leu Leu 
                245                 250                 255     


Asn Pro Tyr Phe Ala Val Ala Thr Ile Leu Lys Ser Met Pro Pro Glu 
            260                 265                 270         


Ile Gln Gln Asp Lys Lys Ser Ala Tyr Val Lys Ala Asn Leu Thr Thr 
        275                 280                 285             


Pro Thr His Asn Ala Leu Ser Trp Ile Phe Gly Lys Gly Leu Thr Leu 
    290                 295                 300                 


Phe Gln Thr Glu Ser Thr Glu Lys Leu Cys Ala Met Phe Asn Val Ser 
305                 310                 315                 320 


Asp Lys Arg Val Ile Glu Gln Val Gln Asp Ala Ala Lys Ala Val Lys 
                325                 330                 335     


Leu Pro Ala Glu Leu Asp Leu Asn His Cys Thr Leu Lys Phe Gln Asp 
            340                 345                 350         


Phe Arg Ser Ser Leu Gly Gly His Leu Asp Ser Trp Thr Thr Asn Tyr 
        355                 360                 365             


Leu Lys Arg Leu Asp Glu Leu Asn Asp Leu Leu Leu Asn Leu Pro Lys 
    370                 375                 380                 


Asn Leu Ser Leu Pro Asp Ile Phe Met Ile Asp Gly Lys Asp Phe Ile 
385                 390                 395                 400 


Glu Tyr Ser Gly Cys Asn Arg Asp Glu Ile Gln Gln Met Ile Asp Phe 
                405                 410                 415     


Val Val Asn Glu Gln Asn Arg Ile Lys Leu Gln Glu Ser Leu Asn Ala 
            420                 425                 430         


Leu Leu Gly Lys Gly Asn Asn Gln Ile Cys Ser Asp Asp Ile Ser Thr 
        435                 440                 445             


Val Lys Asp Phe Ser Glu Ile Val Asn Ser Leu His Ser Phe Val Gln 
    450                 455                 460                 


Gln Ile Asp Asn Ser Leu Glu Gln Ser Ser Asn Glu Ala Asn Ser Ile 
465                 470                 475                 480 


Phe Ser Glu Leu Lys Lys Lys Ile Glu Lys Asn Glu Lys Trp Asp Ile 
                485                 490                 495     


Trp Lys Asn Asn Leu Lys Lys Ile Pro Lys Leu Asn Lys Leu Ser Gly 
            500                 505                 510         


Gly Val Pro Asp Ala Trp Lys Glu Ile Arg Glu Ile Glu Gln Lys Phe 
        515                 520                 525             


His Glu Ile Ser Glu Asn Gln Lys Lys His Phe Thr Glu Val Met Glu 
    530                 535                 540                 


Trp Ile Asp Ala Gly Asn Gly Thr Ile Asp Ile Phe Glu Ser Arg Phe 
545                 550                 555                 560 


Lys Tyr Asp Glu Leu Leu Lys Lys Ser Lys Lys Asn Asn Leu Gln Ser 
                565                 570                 575     


Ala Asp Glu Leu Ala Phe Arg Ser Val Leu Asn Lys Leu Gly Arg Phe 
            580                 585                 590         


Ala Arg Gln Gly Asn Asp Leu Val Cys Glu Lys Ile Lys Asn Trp Phe 
        595                 600                 605             


Lys Glu Gln Asn Ile Phe Asp Ser Ser Lys Asp Phe Asn Arg Tyr Phe 
    610                 615                 620                 


Ile Asn Gln Lys Gly Phe Ile Phe Lys His Pro Ser Ser Lys Lys Asp 
625                 630                 635                 640 


Asn Ser Pro Tyr Asn Leu Ser Ala Asn Leu Leu Glu Lys Arg Tyr Glu 
                645                 650                 655     


Val Thr Asn Thr Val Gly Ala Leu Leu Glu Gln Cys Glu Ser Asp Pro 
            660                 665                 670         


Ala Ile Val Asn Asp Pro Phe Ser Met Arg Ser Leu Val Glu Phe Arg 
        675                 680                 685             


Ala Leu Trp Phe Ser Ile Asn Ile Ser Gly Ile Ser Lys Glu Gln His 
    690                 695                 700                 


Ile Pro Thr Lys Ile Ala Gln Pro Lys Leu Asp Asp Ser Thr Tyr Gln 
705                 710                 715                 720 


Glu Ser Val Ser Pro Thr Leu Lys Tyr Arg Leu Glu Lys Glu Gln Ile 
                725                 730                 735     


Thr Ser Ser Glu Leu Asn Ser Ile Phe Thr Val Tyr Lys Ser Leu Leu 
            740                 745                 750         


Ser Gly Leu Ser Ile Arg Leu Ser Arg Asn Ser Phe Tyr Leu Arg Thr 
        755                 760                 765             


Lys Phe Ser Trp Ile Gly Asn Asn Ser Leu Ile Tyr Cys Pro Lys Glu 
    770                 775                 780                 


Thr Thr Trp Lys Ile Pro Ala Ala Tyr Phe Lys Ser Asp Leu Trp Asn 
785                 790                 795                 800 


Glu Tyr Lys Asp Lys Gln Ile Leu Ile Val Asn Glu Glu Tyr Asp Val 
                805                 810                 815     


Asp Val Val Lys Thr Phe Glu Ser Val Tyr Lys Ile Val Lys Ser Lys 
            820                 825                 830         


Asp Asn Asn Glu Lys Asn Arg Ile Leu Pro Leu Leu Lys Gln Leu Pro 
        835                 840                 845             


His Asp Trp Met Phe Lys Leu Pro Phe Gly Ala Ser Asn Ala Glu Lys 
    850                 855                 860                 


Cys Lys Val Leu Lys Leu Glu Lys Asn Asn Lys Lys Phe Lys Pro Leu 
865                 870                 875                 880 


Ser Val Ser Lys Asp Ser Leu Ala Arg Leu Ser Gly Pro Ser Thr Tyr 
                885                 890                 895     


Phe Asn Gln Ile Asp Glu Ile Met Met Asn Asp Glu Ser Glu Leu Ser 
            900                 905                 910         


Glu Met Thr Leu Leu Ala Asp Glu Pro Val Arg Gln Gln Met Ser Asn 
        915                 920                 925             


Gly Lys Ile Glu Ile Ile Pro Asp Asp Tyr Val Met Ser Leu Ala Ile 
    930                 935                 940                 


Pro Ile Thr Arg Ser Leu Lys Lys Gly Asn Thr Glu Ser Phe Pro Phe 
945                 950                 955                 960 


Lys Asn Ile Val Ser Ile Asp Gln Gly Glu Ala Gly Phe Ala Tyr Ala 
                965                 970                 975     


Val Phe Lys Leu Ser Asp Cys Gly Asn Glu Arg Ala Glu Pro Ile Ala 
            980                 985                 990         


Thr Gly Leu Ile Pro Ile Pro Ser  Ile Arg Arg Leu Ile  His Ser Val 
        995                 1000                 1005             


Lys Lys  Tyr Arg Gly Lys Lys  Gln Arg Ile Gln Asn  Phe Asn Gln 
    1010                 1015                 1020             


Lys Phe  Asp Ser Thr Met Phe  Thr Leu Arg Glu Asn  Val Thr Gly 
    1025                 1030                 1035             


Asp Ile  Cys Gly Leu Ile Val  Ala Leu Met Lys Lys  Tyr Asn Ala 
    1040                 1045                 1050             


Phe Pro  Ile Leu Glu Lys Gln  Val Gly Asn Leu Glu  Ser Gly Ser 
    1055                 1060                 1065             


Lys Gln  Leu Met Leu Val Tyr  Lys Ala Val Asn Ser  Lys Phe Leu 
    1070                 1075                 1080             


Ala Ala  Lys Val Asp Met Gln  Asn Asp Gln Arg Arg  Ser Trp Trp 
    1085                 1090                 1095             


Tyr Gln  Gly Asn Ser Trp Asn  Thr Pro Ile Leu Arg  Ile Ser Asn 
    1100                 1105                 1110             


Pro Asn  Gln Ser Asn Asn Lys  Asn Ile Val Lys Asn  Ile Asn Gly 
    1115                 1120                 1125             


Lys Lys  Tyr Glu Glu Leu Lys  Ile Tyr Pro Gly Tyr  Ser Val Ser 
    1130                 1135                 1140             


Ala Tyr  Met Thr Ser Cys Ile  Cys His Val Cys Gly  Arg Asn Ala 
    1145                 1150                 1155             


Leu Glu  Leu Leu Lys Asn Asp  Asp Ser Thr Gly Lys  Val Lys Lys 
    1160                 1165                 1170             


Tyr Gln  Ile Asn Gln Asp Gly  Glu Val Thr Ile Gly  Gly Glu Val 
    1175                 1180                 1185             


Ile Lys  Leu Tyr Arg Lys Pro  Asp Arg Leu Thr Pro  Val Lys Asn 
    1190                 1195                 1200             


Leu Ala  Lys Lys Gly Asn Arg  Glu Arg Thr Tyr Ala  Ser Ile Asn 
    1205                 1210                 1215             


Glu Arg  Ala Pro Thr Val Ser  Val Gln Lys Ala Glu  Leu Ser Ala 
    1220                 1225                 1230             


Asp Glu  Leu Gln Lys Ile Ile  Lys Lys Asn Met Arg  Arg Ala Pro 
    1235                 1240                 1245             


Arg Ser  Leu Met Ser Lys Asp  Thr Thr Gln Ser Arg  Tyr Phe Cys 
    1250                 1255                 1260             


Val Phe  Lys Asn Cys Pro Cys  His Asn Lys Glu Gln  His Ala Asp 
    1265                 1270                 1275             


Val Asn  Ala Ala Ile Asn Ile  Gly Arg Arg Phe Leu  Lys Asp Cys 
    1280                 1285                 1290             


Ile Leu  Asp Asp Asn Lys Glu  Lys Asp 
    1295                 1300         


<210>  323
<211>  1255
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  323

Met Arg Ser Asn Tyr His Gly Gly Arg Asn Ala Arg Gln Trp Arg Lys 
1               5                   10                  15      


Gln Ile Ser Gly Leu Ala Arg Arg Thr Lys Glu Thr Val Phe Thr Tyr 
            20                  25                  30          


Lys Phe Pro Leu Glu Thr Asp Ala Ala Glu Ile Asp Phe Asp Lys Ala 
        35                  40                  45              


Val Gln Thr Tyr Gly Ile Ala Glu Gly Val Gly His Gly Ser Leu Ile 
    50                  55                  60                  


Gly Leu Val Cys Ala Phe His Leu Ser Gly Phe Arg Leu Phe Ser Lys 
65                  70                  75                  80  


Ala Gly Glu Ala Met Ala Phe Arg Asn Arg Ser Arg Tyr Pro Thr Asp 
                85                  90                  95      


Ala Phe Ala Glu Lys Leu Ser Ala Ile Met Gly Ile Gln Leu Pro Thr 
            100                 105                 110         


Leu Ser Pro Glu Gly Leu Asp Leu Ile Phe Gln Ser Pro Pro Arg Ser 
        115                 120                 125             


Arg Asp Gly Ile Ala Pro Val Trp Ser Glu Asn Glu Val Arg Asn Arg 
    130                 135                 140                 


Leu Tyr Thr Asn Trp Thr Gly Arg Gly Pro Ala Asn Lys Pro Asp Glu 
145                 150                 155                 160 


His Leu Leu Glu Ile Ala Gly Glu Ile Ala Lys Gln Val Phe Pro Lys 
                165                 170                 175     


Phe Gly Gly Trp Asp Asp Leu Ala Ser Asp Pro Asp Lys Ala Leu Ala 
            180                 185                 190         


Ala Ala Asp Lys Tyr Phe Gln Ser Gln Gly Asp Phe Pro Ser Ile Ala 
        195                 200                 205             


Ser Leu Pro Ala Ala Ile Met Leu Ser Pro Ala Asn Ser Thr Val Asp 
    210                 215                 220                 


Phe Glu Gly Asp Tyr Ile Ala Ile Asp Pro Ala Ala Glu Thr Leu Leu 
225                 230                 235                 240 


His Gln Ala Val Ser Arg Cys Ala Ala Arg Leu Gly Arg Glu Arg Pro 
                245                 250                 255     


Asp Leu Asp Gln Asn Lys Gly Pro Phe Val Ser Ser Leu Gln Asp Ala 
            260                 265                 270         


Leu Val Ser Ser Gln Asn Asn Gly Leu Ser Trp Leu Phe Gly Val Gly 
        275                 280                 285             


Phe Gln His Trp Lys Glu Lys Ser Pro Lys Glu Leu Ile Asp Glu Tyr 
    290                 295                 300                 


Lys Val Pro Ala Asp Gln His Gly Ala Val Thr Gln Val Lys Ser Phe 
305                 310                 315                 320 


Val Asp Ala Ile Pro Leu Asn Pro Leu Phe Asp Thr Thr His Tyr Gly 
                325                 330                 335     


Glu Phe Arg Ala Ser Val Ala Gly Lys Val Arg Ser Trp Val Ala Asn 
            340                 345                 350         


Tyr Trp Lys Arg Leu Leu Asp Leu Lys Ser Leu Leu Ala Thr Thr Glu 
        355                 360                 365             


Phe Thr Leu Pro Glu Ser Ile Ser Asp Pro Lys Ala Val Ser Leu Phe 
    370                 375                 380                 


Ser Gly Leu Leu Val Asp Pro Gln Gly Leu Lys Lys Val Ala Asp Ser 
385                 390                 395                 400 


Leu Pro Ala Arg Leu Val Ser Ala Glu Glu Ala Ile Asp Arg Leu Met 
                405                 410                 415     


Gly Val Gly Ile Pro Thr Ala Ala Asp Ile Ala Gln Val Glu Arg Val 
            420                 425                 430         


Ala Asp Glu Ile Gly Ala Phe Ile Gly Gln Val Gln Gln Phe Asn Asn 
        435                 440                 445             


Gln Val Lys Gln Lys Leu Glu Asn Leu Gln Asp Ala Asp Asp Glu Glu 
    450                 455                 460                 


Phe Leu Lys Gly Leu Lys Ile Glu Leu Pro Ser Gly Asp Lys Glu Pro 
465                 470                 475                 480 


Pro Ala Ile Asn Arg Ile Ser Gly Gly Ala Pro Asp Ala Ala Ala Glu 
                485                 490                 495     


Ile Ser Glu Leu Glu Glu Lys Leu Gln Arg Leu Leu Asp Ala Arg Ser 
            500                 505                 510         


Glu His Phe Gln Thr Ile Ser Glu Trp Ala Glu Glu Asn Ala Val Thr 
        515                 520                 525             


Leu Asp Pro Ile Ala Ala Met Val Glu Leu Glu Arg Leu Arg Leu Ala 
    530                 535                 540                 


Glu Arg Gly Ala Thr Gly Asp Pro Glu Glu Tyr Ala Leu Arg Leu Leu 
545                 550                 555                 560 


Leu Gln Arg Ile Gly Arg Leu Ala Asn Arg Val Ser Pro Val Ser Ala 
                565                 570                 575     


Gly Ser Ile Arg Glu Leu Leu Lys Pro Val Phe Met Glu Glu Arg Glu 
            580                 585                 590         


Phe Asn Leu Phe Phe His Asn Arg Leu Gly Ser Leu Tyr Arg Ser Pro 
        595                 600                 605             


Tyr Ser Thr Ser Arg His Gln Pro Phe Ser Ile Asp Val Gly Lys Ala 
    610                 615                 620                 


Lys Ala Ile Asp Trp Ile Ala Gly Leu Asp Gln Ile Ser Ser Asp Ile 
625                 630                 635                 640 


Glu Lys Ala Leu Ser Gly Ala Gly Glu Ala Leu Gly Asp Gln Leu Arg 
                645                 650                 655     


Asp Trp Ile Asn Leu Ala Gly Phe Ala Ile Ser Gln Arg Leu Arg Gly 
            660                 665                 670         


Leu Pro Asp Thr Val Pro Asn Ala Leu Ala Gln Val Arg Cys Pro Asp 
        675                 680                 685             


Asp Val Arg Ile Pro Pro Leu Leu Ala Met Leu Leu Glu Glu Asp Asp 
    690                 695                 700                 


Ile Ala Arg Asp Val Cys Leu Lys Ala Phe Asn Leu Tyr Val Ser Ala 
705                 710                 715                 720 


Ile Asn Gly Cys Leu Phe Gly Ala Leu Arg Glu Gly Phe Ile Val Arg 
                725                 730                 735     


Thr Arg Phe Gln Arg Ile Gly Thr Asp Gln Ile His Tyr Val Pro Lys 
            740                 745                 750         


Asp Lys Ala Trp Glu Tyr Pro Asp Arg Leu Asn Thr Ala Lys Gly Pro 
        755                 760                 765             


Ile Asn Ala Ala Val Ser Ser Asp Trp Ile Glu Lys Asp Gly Ala Val 
    770                 775                 780                 


Ile Lys Pro Val Glu Thr Val Arg Asn Leu Ser Ser Thr Gly Phe Ala 
785                 790                 795                 800 


Gly Ala Gly Val Ser Glu Tyr Leu Val Gln Ala Pro His Asp Trp Tyr 
                805                 810                 815     


Thr Pro Leu Asp Leu Arg Asp Val Ala His Leu Val Thr Gly Leu Pro 
            820                 825                 830         


Val Glu Lys Asn Ile Thr Lys Leu Lys Arg Leu Thr Asn Arg Thr Ala 
        835                 840                 845             


Phe Arg Met Val Gly Ala Ser Ser Phe Lys Thr His Leu Asp Ser Val 
    850                 855                 860                 


Leu Leu Ser Asp Lys Ile Lys Leu Gly Asp Phe Thr Ile Ile Ile Asp 
865                 870                 875                 880 


Gln His Tyr Arg Gln Ser Val Thr Tyr Gly Gly Lys Val Lys Ile Ser 
                885                 890                 895     


Tyr Glu Pro Glu Arg Leu Gln Val Glu Ala Ala Val Pro Val Val Asp 
            900                 905                 910         


Thr Arg Asp Arg Thr Val Pro Glu Pro Asp Thr Leu Phe Asp His Ile 
        915                 920                 925             


Val Ala Ile Asp Leu Gly Glu Arg Ser Val Gly Phe Ala Val Phe Asp 
    930                 935                 940                 


Ile Lys Ser Cys Leu Arg Thr Gly Glu Val Lys Pro Ile His Asp Asn 
945                 950                 955                 960 


Asn Gly Asn Pro Val Val Gly Thr Val Ala Val Pro Ser Ile Arg Arg 
                965                 970                 975     


Leu Met Lys Ala Val Arg Ser His Arg Arg Arg Arg Gln Pro Asn Gln 
            980                 985                 990         


Lys Val Asn Gln Thr Tyr Ser Thr  Ala Leu Gln Asn Tyr  Arg Glu Asn 
        995                 1000                 1005             


Val Ile  Gly Asp Val Cys Asn  Arg Ile Asp Thr Leu  Met Glu Arg 
    1010                 1015                 1020             


Tyr Asn  Ala Phe Pro Val Leu  Glu Phe Gln Ile Lys  Asn Phe Gln 
    1025                 1030                 1035             


Ala Gly  Ala Lys Gln Leu Glu  Ile Val Tyr Gly Ser  Val Leu His 
    1040                 1045                 1050             


Arg Tyr  Thr Phe Ser Gly Val  Asp Ala His Lys Ala  Lys Arg Arg 
    1055                 1060                 1065             


Glu Tyr  Trp Tyr Asn Gly Glu  Leu Trp Glu His Pro  Tyr Leu Met 
    1070                 1075                 1080             


Ala Lys  Lys Trp Asn Glu Glu  Thr Asn Ser Met Ser  Gly Ala Pro 
    1085                 1090                 1095             


Lys Pro  Val Ser Leu Phe Pro  Gly Val Thr Val Asn  Ala Ala Arg 
    1100                 1105                 1110             


Thr Ser  Gln Ile Cys His Gln  Cys Gln Arg Asn Pro  Met Ser His 
    1115                 1120                 1125             


Leu Arg  Gly Leu Thr Gly Thr  Ile Glu Ile Ser Ser  Asp Gly Leu 
    1130                 1135                 1140             


Leu Glu  Leu Asp Asp Gly Thr  Ile Arg Leu Phe Glu  Thr Ser Asp 
    1145                 1150                 1155             


Tyr Asp  Glu Asp Lys Phe Lys  Gln Ser Arg Arg Glu  Lys Arg Arg 
    1160                 1165                 1170             


Leu Asp  Ala Asn Val Leu Leu  Ser Gly Arg His Arg  Ala Glu Tyr 
    1175                 1180                 1185             


Ile Tyr  Thr Val Ala Lys Arg  Asn Leu Arg Arg Pro  Pro Lys Asn 
    1190                 1195                 1200             


Val Met  Thr Lys Asp Thr Thr  Gln Ser Arg Tyr Thr  Cys Leu Tyr 
    1205                 1210                 1215             


Lys Asn  Cys Ser Trp Thr Gly  His Ala Asp Glu Asn  Ala Ala Ile 
    1220                 1225                 1230             


Asn Ile  Gly Arg Arg Tyr Leu  Ala Glu Arg Ile Asp  Met Pro Ala 
    1235                 1240                 1245             


Ser Lys  Thr Lys Ala Ala Val  
    1250                 1255 


<210>  324
<211>  1266
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  324

Met Arg Pro Arg Phe His Gly Gly Met Asn Ala Arg Asp Trp Arg Lys 
1               5                   10                  15      


His Val Gly Val Leu Ala Gln Gln His Lys Glu Thr Thr Arg Thr Tyr 
            20                  25                  30          


Thr Phe Pro Leu Asp Thr Thr Gly Ser Ala Ile Asp Phe Asp Ala Ala 
        35                  40                  45              


Leu Gln Ala Tyr Asn Ala Val Glu Gly Val Gly Tyr Gly Ser Leu Leu 
    50                  55                  60                  


Gly Leu Ala Cys Ala Val His Leu Ser Gly Phe Arg Leu Phe Ser Thr 
65                  70                  75                  80  


Gly Lys Glu Ala Ala Thr Phe Arg Asn Arg Ala Arg Tyr Pro Asn Ala 
                85                  90                  95      


Ala Phe Gln Ala Ala Leu Arg Lys Glu Leu Gly Thr Thr Ile Thr Thr 
            100                 105                 110         


Leu Thr Pro Glu Thr Leu Asp Arg Leu Phe Ser Ser Arg Pro Lys Arg 
        115                 120                 125             


Arg Asn Gly Val Pro Leu Pro Trp Asn Gln Asp Ser Ile Arg Asp Arg 
    130                 135                 140                 


Leu Tyr Thr Asn Trp Val Lys Pro Arg Pro Gly Asp Thr Pro Asp Ala 
145                 150                 155                 160 


Val Leu Phe Gln Ile Ala Thr Gly Ile Ala Gln Glu Ile Thr Glu Asp 
                165                 170                 175     


Val Ser Ser Trp Thr Asp Leu Ala Lys Asn Ser Asp Arg Gly Leu Lys 
            180                 185                 190         


Ala Ala His Arg Tyr Phe Ala Arg Val Gly Gly Phe Pro Ala Phe Asp 
        195                 200                 205             


Asn Leu Thr Pro Pro Ala Thr Val Gln Pro Thr Asp Thr Thr Ile Asp 
    210                 215                 220                 


Tyr Asp Pro Asn Ala Pro Phe His Leu Val Ser His Ala Asp Gln Thr 
225                 230                 235                 240 


Leu Ile His Gln Ser Ile Ser Leu Cys Ala His Arg Ile Arg Gln Glu 
                245                 250                 255     


Asp Pro Ala Leu Asp Pro Asn Lys Ser Gly Phe Ile Lys Gln Leu Gln 
            260                 265                 270         


Asn Asn Phe Leu Ser Gln Thr Phe Tyr Gly Leu Ser Trp Leu Phe Gly 
        275                 280                 285             


Ala Gly Tyr Val His Phe Arg Glu Cys Thr Ala Asn Asp Leu Ala Ile 
    290                 295                 300                 


Gln Tyr Gly Ile Pro Asn Asn Cys Arg Asp Gly Ile His Gln Ile Lys 
305                 310                 315                 320 


Ser Phe Ala Asp Ala Ile Leu Pro Asn Thr Phe Phe Glu Lys Lys His 
                325                 330                 335     


Tyr Arg Lys Asp Ser Arg Ser Val Gly Lys Lys Ala Lys Ser Trp Ile 
            340                 345                 350         


Ser Asn Tyr Trp Gln Arg Leu Leu Gln Leu Gln Thr Trp Val Asp Asp 
        355                 360                 365             


His Thr Trp Val Thr Leu Pro Gln Glu Leu Thr Glu Ala Gln Phe Lys 
    370                 375                 380                 


Pro Leu Phe Arg Gly Leu Leu Val Asp Ala Val Glu Leu Met Ala Ile 
385                 390                 395                 400 


Ala Glu Arg Leu Pro Gln Arg Leu Ala Asp Cys Arg Asp Ser Leu Asp 
                405                 410                 415     


Cys Leu Met Gly Lys Gly Pro Gln Ala Ala Thr Lys Asn Asp Val Glu 
            420                 425                 430         


Ile Val Glu Lys Val Arg Glu Glu Ile Glu Ser Phe Val Gly Gln Ile 
        435                 440                 445             


Glu Gln Leu Gly Asn Gln Leu Arg His Gln Leu Glu Asn Glu Asn Asn 
    450                 455                 460                 


Asp Gln Val His Arg Asp Asn Leu His Gln Leu Lys Asn Arg Leu Pro 
465                 470                 475                 480 


Leu Asp Leu Arg Arg Pro Gln Ala Leu Asn Lys Ile Ser Gly Gly Val 
                485                 490                 495     


Pro Asp Val Ala Lys Ser Ile Arg Gly Leu Glu Thr Gln Leu Asp Gln 
            500                 505                 510         


Val Leu Lys Glu Arg Arg Ser His Phe Gly Arg Leu Thr Lys Trp Ala 
        515                 520                 525             


Lys Glu Cys Gly Ile Thr Leu Asp Pro Leu Gln Pro Leu Ile Glu Ser 
    530                 535                 540                 


Glu Lys Gln Arg Val Ala Glu Arg Gly Ser Ala His Asp Ala Lys Glu 
545                 550                 555                 560 


Leu Ala Ile Arg Leu Leu Leu Gln Arg Ile Gly Arg Leu Gly His Arg 
                565                 570                 575     


Leu Ser Pro Thr Asn Ala Thr Ala Ile Gln Glu Leu Leu Arg Pro Val 
            580                 585                 590         


Phe Ala Val Lys Arg Glu Phe Asn Leu Phe Phe His Asn His Met Gly 
        595                 600                 605             


Ala Leu Tyr Arg Ser Pro Tyr Ser Thr Ser Arg His Gln Pro Phe Gln 
    610                 615                 620                 


Ile Asn Val Asp Val Ala His Gly Thr Asp Trp Ile Gly Thr Ile Glu 
625                 630                 635                 640 


Thr Leu Ile Gln Asn Leu Phe Thr Gln Ile Gln Asp Asp Ala Leu Leu 
                645                 650                 655     


Arg Asp Leu Val Gln Leu Glu Gly Phe Val Phe Ser His Lys Leu Arg 
            660                 665                 670         


Ala Leu Pro Gly Val Ile Pro Ser Glu Leu Ala Arg Pro Asn Asn Leu 
        675                 680                 685             


Gln Gln Met Gly Leu Pro Ala Leu Leu Leu Val Leu Leu Gln Ala Asp 
    690                 695                 700                 


Gln Val His Arg Glu Thr Val Leu Arg Val Phe Asn Leu Tyr Gly Ser 
705                 710                 715                 720 


Ala Ile Asn Gly Tyr Leu Phe Gln Ala Leu Arg Pro Gly Phe Ile Val 
                725                 730                 735     


Arg Ala Gly Phe Gln Arg Leu Glu Thr Lys Lys Leu Arg Tyr Val Pro 
            740                 745                 750         


Lys Ala Gln Ser Trp Gln Tyr Pro Asp Arg Leu His His Ala Lys Ser 
        755                 760                 765             


Ala Ile Lys Asn Ser Leu Ser Ala Gly Trp Ile Lys Lys Asn His Gln 
    770                 775                 780                 


Gly Ala Ile Leu Pro Gln Lys Thr Leu Thr Ala Leu Val Lys Gln Lys 
785                 790                 795                 800 


Ser Leu Lys Asp Thr Gly Val Pro Glu Tyr Leu Val Gln Ala Pro His 
                805                 810                 815     


Asp Trp Tyr Val Pro Ile Asp Leu Arg Gly Pro Ala Ile Pro Ile Glu 
            820                 825                 830         


Gly Leu Thr Val Gly Thr Glu Gly Pro Glu Leu Thr Gln Leu Gly Pro 
        835                 840                 845             


Met Lys Asp Asp Cys Ala Phe Arg Ala Ile Gly Pro Ser Ser Phe Lys 
    850                 855                 860                 


Ser Lys Ile Asp Ala Gly Leu Leu Pro Gln Asp Val Lys Tyr Gly Asp 
865                 870                 875                 880 


Met Thr Leu Ile Phe Asp Gln His Tyr Gln Gln Ser Ile Ser Phe Ala 
                885                 890                 895     


Asn Gly Thr Phe Ser Ile Gln Tyr Gln Pro Thr Ser Leu Gln Val Lys 
            900                 905                 910         


Ala Ala Ile Pro Val Val Asp Lys Arg Pro Arg Asp Thr Arg Asn Asn 
        915                 920                 925             


Ser His Leu Tyr Asp Arg Ile Val Ala Ile Asp Leu Gly Glu Arg Lys 
    930                 935                 940                 


Ile Gly Tyr Ala Ile Phe Asp Leu Lys Gln Val Leu Lys Ser Glu Gln 
945                 950                 955                 960 


Leu Glu Pro Met Arg Glu Asp Gly Lys Pro Leu Ile Gly Ser Ile Ser 
                965                 970                 975     


Ile Arg Ser Ile Arg Gly Leu Met Lys Ala Val Gln Thr His Arg Asn 
            980                 985                 990         


Arg Arg Gln Pro Asn Tyr Arg Ile  Asp Gln Thr Tyr Ser  Lys Ala Leu 
        995                 1000                 1005             


Met His  Tyr Arg Glu Ser Val  Ile Gly Asp Val Cys  Asn Ala Ile 
    1010                 1015                 1020             


Asp Thr  Leu Cys Ala Arg Tyr  Gly Gly Phe Pro Val  Leu Glu Ser 
    1025                 1030                 1035             


Ser Val  Arg Asn Phe Glu Val  Gly Ser Ala Gln Leu  Lys Thr Val 
    1040                 1045                 1050             


Tyr Gly  Ser Val Ser Arg Arg  Tyr Thr Trp Ser Ala  Val Asp Ala 
    1055                 1060                 1065             


His Lys  Asn Gln Arg Gln Gln  Tyr Trp Leu Gly Gly  Thr Lys Asp 
    1070                 1075                 1080             


Lys Ile  Pro Ile Trp Thr His  Pro Tyr Leu Met Thr  Arg Glu Trp 
    1085                 1090                 1095             


Asp Glu  Lys Asn Ser Lys Trp  Ser Asn Arg Ser Lys  Pro Leu Lys 
    1100                 1105                 1110             


Met His  Pro Gly Val Glu Val  His Pro Ala Gly Thr  Ser Gln Ile 
    1115                 1120                 1125             


Cys His  Gln Cys Lys Arg Asn  Pro Ile Gly Ala Leu  Trp Asn Val 
    1130                 1135                 1140             


Ala Asp  Thr Val Val Leu Asp  Asp Gln Gly Gln Leu  Asp Leu Asp 
    1145                 1150                 1155             


Asp Gly  Thr Ile Arg Leu Asn  Ser Gly Tyr Ile Asp  Thr Thr Glu 
    1160                 1165                 1170             


Ile Lys  Arg Ala Arg Arg Lys  Lys Ile Arg Leu Pro  Glu Asn Lys 
    1175                 1180                 1185             


Pro Leu  Thr Gly Ser His Lys  Thr Ser His Val Arg  Ala Val Ala 
    1190                 1195                 1200             


Arg Arg  Asn Leu Arg Gln Pro  Pro Lys Ser Thr Arg  Ala Lys Asp 
    1205                 1210                 1215             


Thr Thr  Gln Ser Arg Tyr Thr  Cys Leu Tyr Val Asp  Cys Gly His 
    1220                 1225                 1230             


Glu Cys  His Ala Asp Glu Asn  Ala Ala Ile Asn Ile  Gly Arg Lys 
    1235                 1240                 1245             


Tyr Leu  Gln Glu Arg Ile His  Ile Glu Ala Ser Arg  Gln Ala Leu 
    1250                 1255                 1260             


Ser Thr  Arg 
    1265     


<210>  325
<211>  1269
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  325

Met Val Ala Gly Leu Lys Lys Ile Lys Arg Asp Gly Val Thr Met Lys 
1               5                   10                  15      


Ser Asn Tyr His Gly Gly Val Lys Ala Arg Ala Trp Arg Lys Arg Ile 
            20                  25                  30          


Gly Gly Leu Ala Arg Arg Gln Lys Glu Thr Val Phe Thr Tyr Lys Phe 
        35                  40                  45              


Pro Leu Glu Thr Glu Glu Ala Gly Ile Asp Phe Asp Lys Ala Val Gln 
    50                  55                  60                  


Thr Tyr Gly Ile Ala Glu Gly Ile Ser Gln Gly Ser Leu Ile Gly Leu 
65                  70                  75                  80  


Val Cys Ala Phe His Leu Ser Gly Phe Arg Leu Phe Ser Lys Ala Asp 
                85                  90                  95      


Glu Thr Lys Ala Phe Cys Asn Gln Gly Arg Tyr Pro Asn Gln Ala Phe 
            100                 105                 110         


Ala Glu Lys Leu Arg Asn Glu Leu Ser Val Thr Leu Pro Lys Leu Ser 
        115                 120                 125             


Pro Gln Ser Leu Asp Val Leu Phe Gln Ser Ser Pro Lys Ser Lys Asn 
    130                 135                 140                 


Gly Val Ala Pro Glu Trp Ser Lys Asn Ala Ile Arg Asn Arg Leu Tyr 
145                 150                 155                 160 


Thr Asn Trp Thr Gly Lys Gly Ala Gly Thr Asn Pro Asp Glu His Leu 
                165                 170                 175     


Leu Glu Ile Ala Glu Asp Ile Ala Ala Glu Ile Asp Ser Asp Leu Asp 
            180                 185                 190         


Gly Trp Lys Asp Leu Glu Glu His Pro Glu Lys Gly Leu Ser Ala Ala 
        195                 200                 205             


Asp Arg Tyr Phe Gln Ala Gln Gly Asp Phe Pro Ser Leu Thr Gly Leu 
    210                 215                 220                 


Pro Pro Ser Val Pro Leu Thr Pro Gln Asn Ser Thr Val Ala Phe Glu 
225                 230                 235                 240 


Gly Asp Pro Val Cys Leu Asn Pro Ser Asp Asn Thr Leu Leu His Gln 
                245                 250                 255     


Ala Val Ala Arg Cys Ala Gly Arg Ile Leu Gln Glu Gln Pro Asn Leu 
            260                 265                 270         


Ser Pro Asp Lys Asn Arg Phe Ile Asn Gln Leu Gln Asp Glu Leu Val 
        275                 280                 285             


Ser Ser Gln Asn Asn Gly Leu Ser Trp Leu Phe Gly Val Gly Phe Lys 
    290                 295                 300                 


Tyr Trp Lys Glu Met Ser Val Asp Gln Leu Ala Asp Asp Tyr Lys Val 
305                 310                 315                 320 


Lys Ser Thr Asp Leu Asp Ala Leu Lys Gln Val Lys Ser Phe Ile Asp 
                325                 330                 335     


Ala Ile Pro Leu Asn Pro Leu Phe Asp Thr Pro His Tyr Gly Glu Phe 
            340                 345                 350         


Arg Ala Ser Val Ala Gly Lys Met Arg Ser Trp Val Lys Asn Tyr Trp 
        355                 360                 365             


Lys Arg Leu Leu Asp Leu Lys Ser Gln Leu Gly Thr Ala Asn Ile Asn 
    370                 375                 380                 


Leu Pro Glu Gly Leu Asp Glu Gln Arg Ala Glu Asn Leu Phe Ser Gly 
385                 390                 395                 400 


Leu Leu Ile Asp Ser Lys Gly Leu Arg Gln Val Thr Asp Lys Leu Pro 
                405                 410                 415     


Ser Arg Leu Lys Lys Ala Glu Asp Thr Ile Asp Arg Leu Met Gly Asp 
            420                 425                 430         


Gly Asn Pro Thr Ser Asp Asp Ile Glu Gln Val Glu Thr Val Ala Ala 
        435                 440                 445             


Glu Ile Ser Ala Phe Ile Gly Gln Val Glu Gln Phe Asn Asn Gln Leu 
    450                 455                 460                 


Glu Gln Arg Leu Glu Asn Pro Leu Glu Gly Asp Asp Glu Thr Phe Leu 
465                 470                 475                 480 


Lys Gln Leu Lys Ile Asp Leu Pro Ala Glu Phe Lys Lys Pro Pro Ala 
                485                 490                 495     


Ile Asn Arg Ile Ser Gly Gly Ser Pro Asp Pro Thr Ala Glu Ile Ala 
            500                 505                 510         


Glu Leu Glu Glu Lys Leu Asp Arg Leu Met Ser Ala Arg Lys Glu His 
        515                 520                 525             


Tyr Glu Thr Ile Ala Glu Trp Ala Ser Ala Asn Lys Val Thr Leu Asp 
    530                 535                 540                 


Pro Met Glu Ala Met Thr Thr Leu Glu Ala Gln Arg Leu Thr Glu Arg 
545                 550                 555                 560 


Gly Ala Glu Gly Asp Gln Glu Glu Phe Ala Leu Arg Leu Leu Leu Gln 
                565                 570                 575     


Arg Ile Gly Arg Leu Ala Asn Arg Leu Ser Pro Gln Gly Ala Thr Ala 
            580                 585                 590         


Ile Arg Asp Leu Leu Arg Pro Val Phe Thr Glu Lys Arg Glu Phe Asn 
        595                 600                 605             


Leu Phe Phe His Asn Arg Met Gly Ser Leu Tyr Arg Ser Pro Tyr Ser 
    610                 615                 620                 


Thr Ser Arg His Gln Pro Phe Thr Ile Asp Val Ala Val Ala Lys Asn 
625                 630                 635                 640 


Thr Asp Trp Met Asp Ala Leu Asp Gly Ile Ala Glu Thr Ile Met Lys 
                645                 650                 655     


Gly Leu Ser Gln Ala Gly Asp Glu Leu Ser Leu Arg Leu Arg Asp Trp 
            660                 665                 670         


Ile Asn Ile Ser Gly Phe Ser Leu Ser Gln Arg Leu Arg Gly Leu Pro 
        675                 680                 685             


Asp Thr Val Pro Gly Glu Leu Ala Leu Val Arg Ser Ala Asp Asp Val 
    690                 695                 700                 


Arg Ile Pro Pro Met Leu Ala Leu Gln Leu Glu Glu Asp Glu Val Ser 
705                 710                 715                 720 


Arg Glu Val Cys Leu Lys Ala Phe Asn Leu Tyr Val Ser Ala Ile Asn 
                725                 730                 735     


Gly Cys Leu Phe Arg Ala Leu Arg Glu Gly Phe Ile Val Arg Thr Lys 
            740                 745                 750         


Phe Gln Arg Leu Glu Arg Asp Val Leu Ser Tyr Val Pro Lys Thr Lys 
        755                 760                 765             


Leu Trp Asn Tyr Pro Gln Arg Leu Asp Thr Ala Arg Gly Pro Ile His 
    770                 775                 780                 


Ser Ala Leu Ala Ala Ala Trp Ile Asn Lys Glu Gly Ser Val Ile Asp 
785                 790                 795                 800 


Pro Val Glu Thr Val Thr Ala Leu Ser Asp Thr Gly Phe Ser Asp Asp 
                805                 810                 815     


Gly Ile Pro Glu Tyr Leu Val Gln Ala Pro His Asp Trp Tyr Thr Pro 
            820                 825                 830         


Ile Asp Leu Arg Asp Ile Ser Lys Pro Val Ser Gly Leu Pro Val Lys 
        835                 840                 845             


Lys Asn Ile Thr Gly Leu Lys Arg Gln Lys Lys Gln Thr Ala Phe Arg 
    850                 855                 860                 


Met Val Gly Pro Ser Ser Phe Lys Ser His Leu Asp Ser Thr Leu Leu 
865                 870                 875                 880 


Ser Glu Glu Val Lys Leu Gly Asp Phe Thr Leu Ile Phe Asp Gln Tyr 
                885                 890                 895     


Tyr Lys Gln Arg Val Ser Tyr Asn Gly Arg Val Lys Ile Thr Phe Glu 
            900                 905                 910         


Pro Asp Arg Leu His Val Glu Ala Ala Val Pro Val Ile Asp Lys Arg 
        915                 920                 925             


Val Arg Pro Ser Thr Glu Glu Asp Ala Leu Phe Asp His Leu Leu Ala 
    930                 935                 940                 


Ile Asp Leu Gly Glu Lys Arg Val Gly Tyr Ala Val Tyr Asp Ile Lys 
945                 950                 955                 960 


Ala Cys Leu Arg Thr Gly Asp Ile Lys Pro Leu Glu Asp Gly Asp Gly 
                965                 970                 975     


Lys Pro Ile Val Gly Ser Val Ala Val Pro Ser Ile Arg Arg Leu Met 
            980                 985                 990         


Lys Ala Val Arg Ser His Arg Gln  Gln Arg Gln Pro Asn  Gln Lys Val 
        995                 1000                 1005             


Asn Gln  Thr Tyr Ser Thr Ala  Leu Met Asn Tyr Arg  Glu Asn Val 
    1010                 1015                 1020             


Ile Gly  Asp Val Cys Asn Arg  Ile Asp Thr Leu Met  Glu Lys Tyr 
    1025                 1030                 1035             


Asn Ala  Phe Pro Val Leu Glu  Ser Ser Val Met Asn  Phe Glu Ala 
    1040                 1045                 1050             


Gly Ser  Arg Gln Leu Glu Met  Val Tyr Gly Ser Val  Leu His Arg 
    1055                 1060                 1065             


Tyr Thr  Tyr Ser Lys Ile Asp  Ala His Thr Ala Lys  Arg Lys Glu 
    1070                 1075                 1080             


Tyr Trp  Tyr Thr Gly Glu Tyr  Trp Asp His Pro Tyr  Leu Met Ala 
    1085                 1090                 1095             


His Lys  Trp Asn Glu Arg Thr  Arg Ser Tyr Ser Gly  Ser Leu Ser 
    1100                 1105                 1110             


Ala Leu  Thr Leu Tyr Pro Gly  Val Met Val His Pro  Ala Gly Thr 
    1115                 1120                 1125             


Ser Gln  Arg Cys His Gln Cys  Lys Arg Asn Pro Met  Val Glu Ile 
    1130                 1135                 1140             


Lys Gln  Leu Thr Gly Gln Val  Glu Ile Asn Ala Asp  Gly Ser Leu 
    1145                 1150                 1155             


Glu Leu  Asp Asp Gly Thr Ile  Cys Leu Tyr Glu Gly  Tyr Asp Tyr 
    1160                 1165                 1170             


Ser Pro  Glu Glu Tyr Lys Lys  Ala Lys Arg Glu Lys  Arg Arg Leu 
    1175                 1180                 1185             


Asp Pro  Asn Val Pro Leu Ser  Gly Arg His Gln Ala  Lys His Val 
    1190                 1195                 1200             


Ser Ala  Val Ala Lys Arg Asn  Leu Arg Arg Pro Thr  Val Ser Met 
    1205                 1210                 1215             


Met Ser  Gly Asp Thr Thr Gln  Ala Arg Tyr Val Cys  Leu Tyr Thr 
    1220                 1225                 1230             


Asp Cys  Asp Phe Thr Gly His  Ala Asp Glu Asn Ala  Ala Ile Asn 
    1235                 1240                 1245             


Ile Gly  Trp Lys Tyr Leu Thr  Glu Arg Ile Ala Leu  Ser Glu Ser 
    1250                 1255                 1260             


Lys Asp  Lys Ala Gly Val 
    1265                 


<210>  326
<211>  1340
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  326

Met Gln Ile Ser Lys Val Asn His Lys His Val Ala Val Gly Gln Lys 
1               5                   10                  15      


Asp Arg Glu Arg Ile Thr Gly Phe Ile Tyr Asn Asp Pro Val Gly Asp 
            20                  25                  30          


Glu Lys Ser Leu Glu Asp Val Val Ala Lys Arg Ala Asn Asp Thr Lys 
        35                  40                  45              


Val Leu Phe Asn Val Phe Asn Thr Lys Asp Leu Tyr Asp Ser Gln Glu 
    50                  55                  60                  


Ser Asp Lys Ser Glu Lys Asp Lys Glu Ile Ile Ser Lys Gly Ala Lys 
65                  70                  75                  80  


Phe Val Ala Lys Ser Phe Asn Ser Ala Ile Thr Ile Leu Lys Lys Gln 
                85                  90                  95      


Asn Lys Ile Tyr Ser Thr Leu Thr Ser Gln Gln Val Ile Lys Glu Leu 
            100                 105                 110         


Lys Asp Lys Phe Gly Gly Ala Arg Ile Tyr Asp Asp Asp Ile Glu Glu 
        115                 120                 125             


Ala Leu Thr Glu Thr Leu Lys Lys Ser Phe Arg Lys Glu Asn Val Arg 
    130                 135                 140                 


Asn Ser Ile Lys Val Leu Ile Glu Asn Ala Ala Gly Ile Arg Ser Ser 
145                 150                 155                 160 


Leu Ser Lys Asp Glu Glu Glu Leu Ile Gln Glu Tyr Phe Val Lys Gln 
                165                 170                 175     


Leu Val Glu Glu Tyr Thr Lys Thr Lys Leu Gln Lys Asn Val Val Lys 
            180                 185                 190         


Ser Ile Lys Asn Gln Asn Met Val Ile Gln Pro Asp Ser Asp Ser Gln 
        195                 200                 205             


Val Leu Ser Leu Ser Glu Ser Arg Arg Glu Lys Gln Ser Ser Ala Val 
    210                 215                 220                 


Ser Ser Asp Thr Leu Val Asn Cys Lys Glu Lys Asp Val Leu Lys Ala 
225                 230                 235                 240 


Phe Leu Thr Asp Tyr Ala Val Leu Asp Glu Asp Glu Arg Asn Ser Leu 
                245                 250                 255     


Leu Trp Lys Leu Arg Asn Leu Val Asn Leu Tyr Phe Tyr Gly Ser Glu 
            260                 265                 270         


Ser Ile Arg Asp Tyr Ser Tyr Thr Lys Glu Lys Ser Val Trp Lys Glu 
        275                 280                 285             


His Asp Glu Gln Lys Ala Asn Lys Thr Leu Phe Ile Asp Glu Ile Cys 
    290                 295                 300                 


His Ile Thr Lys Ile Gly Lys Asn Gly Lys Glu Gln Lys Val Leu Asp 
305                 310                 315                 320 


Tyr Glu Glu Asn Arg Ser Arg Cys Arg Lys Gln Asn Ile Asn Tyr Tyr 
                325                 330                 335     


Arg Ser Ala Leu Asn Tyr Ala Lys Asn Asn Thr Ser Gly Ile Phe Glu 
            340                 345                 350         


Asn Glu Asp Ser Asn His Phe Trp Ile His Leu Ile Glu Asn Glu Val 
        355                 360                 365             


Glu Arg Leu Tyr Asn Gly Ile Glu Asn Gly Glu Glu Phe Lys Phe Glu 
    370                 375                 380                 


Thr Gly Tyr Ile Ser Glu Lys Val Trp Lys Ala Val Ile Asn His Leu 
385                 390                 395                 400 


Ser Ile Lys Tyr Ile Ala Leu Gly Lys Ala Val Tyr Asn Tyr Ala Met 
                405                 410                 415     


Lys Glu Leu Ser Ser Pro Gly Asp Ile Glu Pro Gly Lys Ile Asp Asp 
            420                 425                 430         


Ser Tyr Ile Asn Gly Ile Thr Ser Phe Asp Tyr Glu Ile Ile Lys Ala 
        435                 440                 445             


Glu Glu Ser Leu Gln Arg Asp Ile Ser Met Asn Val Val Phe Ala Thr 
    450                 455                 460                 


Asn Tyr Leu Ala Cys Ala Thr Val Asp Thr Asp Lys Asp Phe Leu Leu 
465                 470                 475                 480 


Phe Ser Lys Glu Asp Ile Arg Ser Cys Thr Lys Lys Asp Gly Asn Leu 
                485                 490                 495     


Cys Lys Asn Ile Met Gln Phe Trp Gly Gly Tyr Ser Thr Trp Lys Asn 
            500                 505                 510         


Phe Cys Glu Glu Tyr Leu Lys Asp Asp Lys Asp Ala Leu Glu Leu Leu 
        515                 520                 525             


Tyr Ser Leu Lys Ser Met Leu Tyr Ser Met Arg Asn Ser Ser Phe His 
    530                 535                 540                 


Phe Ser Thr Glu Asn Val Asp Asn Gly Ser Trp Asp Thr Glu Leu Ile 
545                 550                 555                 560 


Gly Lys Leu Phe Glu Glu Asp Cys Asn Arg Ala Ala Arg Ile Glu Lys 
                565                 570                 575     


Glu Lys Phe Tyr Asn Asn Asn Leu His Met Phe Tyr Ser Ser Ser Leu 
            580                 585                 590         


Leu Glu Lys Val Leu Glu Arg Leu Tyr Ser Ser His His Glu Arg Ala 
        595                 600                 605             


Ser Gln Val Pro Ser Phe Asn Arg Val Phe Val Arg Lys Asn Phe Pro 
    610                 615                 620                 


Ser Ser Leu Ser Glu Gln Arg Ile Thr Pro Lys Phe Thr Asp Ser Lys 
625                 630                 635                 640 


Asp Glu Gln Ile Trp Gln Ser Ala Val Tyr Tyr Leu Cys Lys Glu Ile 
                645                 650                 655     


Tyr Tyr Asn Asp Phe Leu Gln Ser Lys Glu Ala Tyr Lys Leu Phe Arg 
            660                 665                 670         


Glu Gly Val Lys Asn Leu Asp Lys Asn Asp Ile Asn Asn Gln Lys Ala 
        675                 680                 685             


Ala Asp Ser Phe Lys Gln Ala Val Val Tyr Tyr Gly Lys Ala Ile Gly 
    690                 695                 700                 


Asn Ala Thr Leu Ser Gln Val Cys Gln Ala Ile Met Thr Glu Tyr Asn 
705                 710                 715                 720 


Arg Gln Asn Asn Asp Gly Leu Lys Lys Lys Ser Ala Tyr Ala Glu Lys 
                725                 730                 735     


Gln Asn Ser Asn Lys Tyr Lys His Tyr Pro Leu Phe Leu Lys Gln Val 
            740                 745                 750         


Leu Gln Ser Ala Phe Trp Glu Tyr Leu Asp Glu Asn Lys Glu Ile Tyr 
        755                 760                 765             


Gly Phe Ile Ser Ala Gln Ile His Lys Ser Asn Val Glu Ile Lys Ala 
    770                 775                 780                 


Glu Asp Phe Ile Ala Asn Tyr Ser Ser Gln Gln Tyr Lys Lys Leu Val 
785                 790                 795                 800 


Asp Lys Val Lys Lys Thr Pro Glu Leu Gln Lys Trp Tyr Thr Leu Gly 
                805                 810                 815     


Arg Leu Ile Asn Pro Arg Gln Ala Asn Gln Phe Leu Gly Ser Ile Arg 
            820                 825                 830         


Asn Tyr Val Gln Phe Val Lys Asp Ile Gln Arg Arg Ala Lys Glu Asn 
        835                 840                 845             


Gly Asn Pro Ile Arg Asn Tyr Tyr Glu Val Leu Glu Ser Asp Ser Ile 
    850                 855                 860                 


Ile Lys Ile Leu Glu Met Cys Thr Lys Leu Asn Gly Thr Thr Ser Asn 
865                 870                 875                 880 


Asp Ile His Asp Tyr Phe Arg Asp Glu Asp Glu Tyr Ala Glu Tyr Ile 
                885                 890                 895     


Ser Gln Phe Val Asn Phe Gly Asp Val His Ser Gly Ala Ala Leu Asn 
            900                 905                 910         


Ala Phe Cys Asn Ser Glu Ser Glu Gly Lys Lys Asn Gly Ile Tyr Tyr 
        915                 920                 925             


Asp Gly Ile Asn Pro Ile Val Asn Arg Asn Trp Val Leu Cys Lys Leu 
    930                 935                 940                 


Tyr Gly Ser Pro Asp Leu Ile Ser Lys Ile Ile Ser Arg Val Asn Glu 
945                 950                 955                 960 


Asn Met Ile His Asp Phe His Lys Gln Glu Asp Leu Ile Arg Glu Tyr 
                965                 970                 975     


Gln Ile Lys Gly Ile Cys Ser Asn Lys Lys Glu Gln Gln Asp Leu Arg 
            980                 985                 990         


Thr Phe Gln Val Leu Lys Asn Arg  Val Glu Leu Arg Asp  Ile Val Glu 
        995                 1000                 1005             


Tyr Ser  Glu Ile Ile Asn Glu  Leu Tyr Gly Gln Leu  Ile Lys Trp 
    1010                 1015                 1020             


Cys Tyr  Leu Arg Glu Arg Asp  Leu Met Tyr Phe Gln  Leu Gly Phe 
    1025                 1030                 1035             


His Tyr  Leu Cys Leu Asn Asn  Ala Ser Ser Lys Glu  Ala Asp Tyr 
    1040                 1045                 1050             


Ile Lys  Ile Asn Val Asp Asp  Arg Asn Ile Ser Gly  Ala Ile Leu 
    1055                 1060                 1065             


Tyr Gln  Ile Ala Ala Met Tyr  Ile Asn Gly Leu Pro  Val Tyr Tyr 
    1070                 1075                 1080             


Lys Lys  Asp Asp Met Tyr Val  Ala Leu Lys Ser Gly  Lys Lys Ala 
    1085                 1090                 1095             


Ser Asp  Glu Leu Asn Ser Asn  Glu Gln Thr Ser Lys  Lys Ile Asn 
    1100                 1105                 1110             


Tyr Phe  Leu Lys Tyr Gly Asn  Asn Ile Leu Gly Asp  Lys Lys Asp 
    1115                 1120                 1125             


Gln Leu  Tyr Leu Ala Gly Leu  Glu Leu Phe Glu Asn  Val Ala Glu 
    1130                 1135                 1140             


His Glu  Asn Ile Ile Ile Phe  Arg Asn Glu Ile Asp  His Phe His 
    1145                 1150                 1155             


Tyr Phe  Tyr Asp Arg Asp Arg  Ser Met Leu Asp Leu  Tyr Ser Glu 
    1160                 1165                 1170             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Leu  Arg Lys Asn 
    1175                 1180                 1185             


Val Val  Asn Met Leu Tyr Asn  Ile Leu Leu Asp His  Asn Ile Val 
    1190                 1195                 1200             


Ser Ser  Phe Val Phe Glu Thr  Gly Glu Lys Lys Val  Gly Arg Gly 
    1205                 1210                 1215             


Asp Ser  Glu Val Ile Lys Pro  Ser Ala Lys Ile Arg  Leu Arg Ala 
    1220                 1225                 1230             


Asn Asn  Gly Val Ser Ser Asp  Val Phe Thr Tyr Lys  Val Gly Ser 
    1235                 1240                 1245             


Lys Asp  Glu Leu Lys Ile Ala  Thr Leu Pro Ala Lys  Asn Glu Glu 
    1250                 1255                 1260             


Phe Leu  Leu Asn Val Ala Arg  Leu Ile Tyr Tyr Pro  Asp Met Glu 
    1265                 1270                 1275             


Ala Val  Ser Glu Asn Met Val  Arg Glu Gly Val Val  Lys Val Glu 
    1280                 1285                 1290             


Lys Ser  Asn Asp Lys Lys Gly  Lys Ile Ser Arg Gly  Ser Asn Thr 
    1295                 1300                 1305             


Arg Ser  Ser Asn Gln Ser Lys  Tyr Asn Asn Lys Ser  Lys Asn Arg 
    1310                 1315                 1320             


Met Asn  Tyr Ser Met Gly Ser  Ile Phe Glu Lys Met  Asp Leu Lys 
    1325                 1330                 1335             


Phe Asp  
    1340 


<210>  327
<211>  1437
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  327

Met Lys Ile Ser Lys Val Arg Glu Glu Asn Arg Gly Ala Lys Leu Thr 
1               5                   10                  15      


Val Asn Ala Lys Thr Ala Val Val Ser Glu Asn Arg Ser Gln Glu Gly 
            20                  25                  30          


Ile Leu Tyr Asn Asp Pro Ser Arg Tyr Gly Lys Ser Arg Lys Asn Asp 
        35                  40                  45              


Glu Asp Arg Asp Arg Tyr Ile Glu Ser Arg Leu Lys Ser Ser Gly Lys 
    50                  55                  60                  


Leu Tyr Arg Ile Phe Asn Glu Asp Lys Asn Lys Arg Glu Thr Asp Glu 
65                  70                  75                  80  


Leu Gln Trp Phe Leu Ser Glu Ile Val Lys Lys Ile Asn Arg Arg Asn 
                85                  90                  95      


Gly Leu Val Leu Ser Asp Met Leu Ser Val Asp Asp Arg Ala Phe Glu 
            100                 105                 110         


Lys Ala Phe Glu Lys Tyr Ala Glu Leu Ser Tyr Thr Asn Arg Arg Asn 
        115                 120                 125             


Lys Val Ser Gly Ser Pro Ala Phe Glu Thr Cys Gly Val Asp Ala Ala 
    130                 135                 140                 


Thr Ala Glu Arg Leu Lys Gly Ile Ile Ser Glu Thr Asn Phe Ile Asn 
145                 150                 155                 160 


Arg Ile Lys Asn Asn Ile Asp Asn Lys Val Ser Glu Asp Ile Ile Asp 
                165                 170                 175     


Arg Ile Ile Ala Lys Tyr Leu Lys Lys Ser Leu Cys Arg Glu Arg Val 
            180                 185                 190         


Lys Arg Gly Leu Lys Lys Leu Leu Met Asn Ala Phe Asp Leu Pro Tyr 
        195                 200                 205             


Ser Asp Pro Asp Ile Asp Val Gln Arg Asp Phe Ile Asp Tyr Val Leu 
    210                 215                 220                 


Glu Asp Phe Tyr His Val Arg Ala Lys Ser Gln Val Ser Arg Ser Ile 
225                 230                 235                 240 


Lys Asn Met Asn Met Pro Val Gln Pro Glu Gly Asp Gly Lys Phe Ala 
                245                 250                 255     


Ile Thr Val Ser Lys Gly Gly Thr Glu Ser Gly Asn Lys Arg Ser Ala 
            260                 265                 270         


Glu Lys Glu Ala Phe Lys Lys Phe Leu Ser Asp Tyr Ala Ser Leu Asp 
        275                 280                 285             


Glu Arg Val Arg Asp Asp Met Leu Arg Arg Met Arg Arg Leu Val Val 
    290                 295                 300                 


Leu Tyr Phe Tyr Gly Ser Asp Asp Ser Lys Leu Ser Asp Val Asn Glu 
305                 310                 315                 320 


Lys Phe Asp Val Trp Glu Asp His Ala Ala Arg Arg Val Asp Asn Arg 
                325                 330                 335     


Glu Phe Ile Lys Leu Pro Leu Glu Asn Lys Leu Ala Asn Gly Lys Thr 
            340                 345                 350         


Asp Lys Asp Ala Glu Arg Ile Arg Lys Asn Thr Val Lys Glu Leu Tyr 
        355                 360                 365             


Arg Asn Gln Asn Ile Gly Cys Tyr Arg Gln Ala Val Lys Ala Val Glu 
    370                 375                 380                 


Glu Asp Asn Asn Gly Arg Tyr Phe Asp Asp Lys Met Leu Asn Met Phe 
385                 390                 395                 400 


Phe Ile His Arg Ile Glu Tyr Gly Val Glu Lys Ile Tyr Ala Asn Leu 
                405                 410                 415     


Lys Gln Val Thr Glu Phe Lys Ala Arg Thr Gly Tyr Leu Ser Glu Lys 
            420                 425                 430         


Ile Trp Lys Asp Leu Ile Asn Tyr Ile Ser Ile Lys Tyr Ile Ala Met 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Tyr Ala Met Asp Glu Leu Asn Ala Ser Asp 
    450                 455                 460                 


Lys Lys Glu Ile Glu Leu Gly Lys Ile Ser Glu Glu Tyr Leu Ser Gly 
465                 470                 475                 480 


Ile Ser Ser Phe Asp Tyr Glu Leu Ile Lys Ala Glu Glu Met Leu Gln 
                485                 490                 495     


Arg Glu Thr Ala Val Tyr Val Ala Phe Ala Ala Arg His Leu Ser Ser 
            500                 505                 510         


Gln Thr Val Glu Leu Asp Ser Glu Asn Ser Asp Phe Leu Leu Leu Lys 
        515                 520                 525             


Pro Lys Gly Thr Met Asp Lys Asn Asp Lys Asn Lys Leu Ala Ser Asn 
    530                 535                 540                 


Asn Ile Leu Asn Phe Leu Lys Asp Lys Glu Thr Leu Arg Asp Thr Ile 
545                 550                 555                 560 


Leu Gln Tyr Phe Gly Gly His Ser Leu Trp Thr Asp Phe Pro Phe Asp 
                565                 570                 575     


Lys Tyr Leu Ala Gly Gly Lys Asp Asp Val Asp Phe Leu Thr Asp Leu 
            580                 585                 590         


Lys Asp Val Ile Tyr Ser Met Arg Asn Asp Ser Phe His Tyr Ala Thr 
        595                 600                 605             


Glu Asn His Asn Asn Gly Lys Trp Asn Lys Glu Leu Ile Ser Ala Met 
    610                 615                 620                 


Phe Glu His Glu Thr Glu Arg Met Thr Val Val Met Lys Asp Lys Phe 
625                 630                 635                 640 


Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Asn Asp Asp Leu Lys Lys 
                645                 650                 655     


Leu Leu Ile Asp Leu Tyr Lys Asp Asn Val Glu Arg Ala Ser Gln Val 
            660                 665                 670         


Pro Ser Phe Asn Lys Val Phe Val Arg Lys Asn Phe Pro Ala Leu Val 
        675                 680                 685             


Arg Asp Lys Asp Asn Leu Gly Ile Glu Leu Asp Leu Lys Ala Asp Ala 
    690                 695                 700                 


Asp Lys Gly Glu Asn Glu Leu Lys Phe Tyr Asn Ala Leu Tyr Tyr Met 
705                 710                 715                 720 


Phe Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Asn Asp Lys Asn Val Arg 
                725                 730                 735     


Glu Arg Phe Ile Thr Lys Ala Thr Lys Val Ala Asp Asn Tyr Asp Arg 
            740                 745                 750         


Asn Lys Glu Arg Asn Leu Lys Asp Arg Ile Lys Ser Ala Gly Ser Asp 
        755                 760                 765             


Glu Lys Lys Lys Leu Arg Glu Gln Leu Gln Asn Tyr Ile Ala Glu Asn 
    770                 775                 780                 


Asp Phe Gly Gln Arg Ile Lys Asn Ile Val Gln Val Asn Pro Asp Tyr 
785                 790                 795                 800 


Thr Leu Ala Gln Ile Cys Gln Leu Ile Met Thr Glu Tyr Asn Gln Gln 
                805                 810                 815     


Asn Asn Gly Cys Met Gln Lys Lys Ser Ala Ala Arg Lys Asp Ile Asn 
            820                 825                 830         


Lys Asp Ser Tyr Gln His Tyr Lys Met Leu Leu Leu Val Asn Leu Arg 
        835                 840                 845             


Lys Ala Phe Leu Glu Phe Ile Lys Glu Asn Tyr Ala Phe Val Leu Lys 
    850                 855                 860                 


Pro Tyr Lys His Asp Leu Cys Asp Lys Ala Asp Phe Val Pro Asp Phe 
865                 870                 875                 880 


Ala Lys Tyr Val Lys Pro Tyr Ala Gly Leu Ile Ser Arg Val Ala Gly 
                885                 890                 895     


Ser Ser Glu Leu Gln Lys Trp Tyr Ile Val Ser Arg Phe Leu Ser Pro 
            900                 905                 910         


Ala Gln Ala Asn His Met Leu Gly Phe Leu His Ser Tyr Lys Gln Tyr 
        915                 920                 925             


Val Trp Asp Ile Tyr Arg Arg Ala Ser Glu Thr Gly Thr Glu Ile Asn 
    930                 935                 940                 


His Ser Ile Ala Glu Asp Lys Ile Ala Gly Val Asp Ile Thr Asp Val 
945                 950                 955                 960 


Asp Ala Val Ile Asp Leu Ser Val Lys Leu Cys Gly Thr Ile Ser Ser 
                965                 970                 975     


Glu Ile Ser Asp Tyr Phe Lys Asp Asp Glu Val Tyr Ala Glu Tyr Ile 
            980                 985                 990         


Ser Ser Tyr Leu Asp Phe Glu Tyr  Asp Gly Gly Asn Tyr  Lys Asp Ser 
        995                 1000                 1005             


Leu Asn  Arg Phe Cys Asn Ser  Asp Ala Val Asn Asp  Gln Lys Val 
    1010                 1015                 1020             


Ala Leu  Tyr Tyr Asp Gly Glu  His Pro Lys Leu Asn  Arg Asn Ile 
    1025                 1030                 1035             


Ile Leu  Ser Lys Leu Tyr Gly  Glu Arg Arg Phe Leu  Glu Lys Ile 
    1040                 1045                 1050             


Thr Asp  Arg Val Ser Arg Ser  Asp Ile Val Glu Tyr  Tyr Lys Leu 
    1055                 1060                 1065             


Lys Lys  Glu Thr Ser Gln Tyr  Gln Thr Lys Gly Ile  Phe Asp Ser 
    1070                 1075                 1080             


Glu Asp  Glu Gln Lys Asn Ile  Lys Lys Phe Gln Glu  Met Lys Asn 
    1085                 1090                 1095             


Ile Val  Glu Phe Arg Asp Leu  Met Asp Tyr Ser Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Leu  Gln Gly Gln Leu Ile  Asn Trp Ile Tyr Leu  Arg Glu Arg 
    1115                 1120                 1125             


Asp Leu  Met Asn Phe Gln Leu  Gly Tyr His Tyr Ala  Cys Leu Asn 
    1130                 1135                 1140             


Asn Asp  Ser Asn Lys Gln Ala  Thr Tyr Val Thr Leu  Asp Tyr Gln 
    1145                 1150                 1155             


Gly Lys  Lys Asn Arg Lys Ile  Asn Gly Ala Ile Leu  Tyr Gln Ile 
    1160                 1165                 1170             


Cys Ala  Met Tyr Ile Asn Gly  Leu Pro Leu Tyr Tyr  Val Asp Lys 
    1175                 1180                 1185             


Asp Ser  Ser Glu Trp Thr Val  Ser Asp Gly Lys Glu  Ser Thr Gly 
    1190                 1195                 1200             


Ala Lys  Ile Gly Glu Phe Tyr  Arg Tyr Ala Lys Ser  Phe Glu Asn 
    1205                 1210                 1215             


Thr Ser  Asp Cys Tyr Ala Ser  Gly Leu Glu Ile Phe  Glu Asn Ile 
    1220                 1225                 1230             


Ser Glu  His Asp Asn Ile Thr  Glu Leu Arg Asn Tyr  Ile Glu His 
    1235                 1240                 1245             


Phe Arg  Tyr Tyr Ser Ser Phe  Asp Arg Ser Phe Leu  Gly Ile Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Arg 
    1265                 1270                 1275             


Lys Asn  Val Pro Thr Ile Leu  Tyr Asn Ile Leu Leu  Gln His Phe 
    1280                 1285                 1290             


Val Asn  Val Arg Phe Glu Phe  Val Ser Gly Lys Lys  Met Ile Gly 
    1295                 1300                 1305             


Ile Asp  Lys Lys Asp Arg Lys  Ile Ala Lys Glu Lys  Glu Cys Ala 
    1310                 1315                 1320             


Arg Ile  Thr Ile Arg Glu Lys  Asn Gly Val Tyr Ser  Glu Gln Phe 
    1325                 1330                 1335             


Thr Tyr  Lys Leu Lys Asn Gly  Thr Val Tyr Val Asp  Ala Arg Asp 
    1340                 1345                 1350             


Lys Arg  Tyr Leu Gln Ser Ile  Ile Arg Leu Leu Phe  Tyr Pro Glu 
    1355                 1360                 1365             


Lys Val  Asn Met Asp Glu Met  Ile Glu Val Lys Glu  Lys Lys Lys 
    1370                 1375                 1380             


Pro Ser  Asp Asn Asn Thr Gly  Lys Gly Tyr Ser Lys  Arg Asp Arg 
    1385                 1390                 1395             


Gln Gln  Asp Arg Lys Glu Tyr  Asp Lys Tyr Lys Glu  Lys Lys Lys 
    1400                 1405                 1410             


Lys Glu  Gly Asn Phe Leu Ser  Gly Met Gly Gly Asn  Ile Asn Trp 
    1415                 1420                 1425             


Asp Glu  Ile Asn Ala Gln Leu  Lys Asn 
    1430                 1435         


<210>  328
<211>  1385
<212>  PRT
<213>  Clostridium aminophilum

<400>  328

Met Lys Phe Ser Lys Val Asp His Thr Arg Ser Ala Val Gly Ile Gln 
1               5                   10                  15      


Lys Ala Thr Asp Ser Val His Gly Met Leu Tyr Thr Asp Pro Lys Lys 
            20                  25                  30          


Gln Glu Val Asn Asp Leu Asp Lys Arg Phe Asp Gln Leu Asn Val Lys 
        35                  40                  45              


Ala Lys Arg Leu Tyr Asn Val Phe Asn Gln Ser Lys Ala Glu Glu Asp 
    50                  55                  60                  


Asp Asp Glu Lys Arg Phe Gly Lys Val Val Lys Lys Leu Asn Arg Glu 
65                  70                  75                  80  


Leu Lys Asp Leu Leu Phe His Arg Glu Val Ser Arg Tyr Asn Ser Ile 
                85                  90                  95      


Gly Asn Ala Lys Tyr Asn Tyr Tyr Gly Ile Lys Ser Asn Pro Glu Glu 
            100                 105                 110         


Ile Val Ser Asn Leu Gly Met Val Glu Ser Leu Lys Gly Glu Arg Asp 
        115                 120                 125             


Pro Gln Lys Val Ile Ser Lys Leu Leu Leu Tyr Tyr Leu Arg Lys Gly 
    130                 135                 140                 


Leu Lys Pro Gly Thr Asp Gly Leu Arg Met Ile Leu Glu Ala Ser Cys 
145                 150                 155                 160 


Gly Leu Arg Lys Leu Ser Gly Asp Glu Lys Glu Leu Lys Val Phe Leu 
                165                 170                 175     


Gln Thr Leu Asp Glu Asp Phe Glu Lys Lys Thr Phe Lys Lys Asn Leu 
            180                 185                 190         


Ile Arg Ser Ile Glu Asn Gln Asn Met Ala Val Gln Pro Ser Asn Glu 
        195                 200                 205             


Gly Asp Pro Ile Ile Gly Ile Thr Gln Gly Arg Phe Asn Ser Gln Lys 
    210                 215                 220                 


Asn Glu Glu Lys Ser Ala Ile Glu Arg Met Met Ser Met Tyr Ala Asp 
225                 230                 235                 240 


Leu Asn Glu Asp His Arg Glu Asp Val Leu Arg Lys Leu Arg Arg Leu 
                245                 250                 255     


Asn Val Leu Tyr Phe Asn Val Asp Thr Glu Lys Thr Glu Glu Pro Thr 
            260                 265                 270         


Leu Pro Gly Glu Val Asp Thr Asn Pro Val Phe Glu Val Trp His Asp 
        275                 280                 285             


His Glu Lys Gly Lys Glu Asn Asp Arg Gln Phe Ala Thr Phe Ala Lys 
    290                 295                 300                 


Ile Leu Thr Glu Asp Arg Glu Thr Arg Lys Lys Glu Lys Leu Ala Val 
305                 310                 315                 320 


Lys Glu Ala Leu Asn Asp Leu Lys Ser Ala Ile Arg Asp His Asn Ile 
                325                 330                 335     


Met Ala Tyr Arg Cys Ser Ile Lys Val Thr Glu Gln Asp Lys Asp Gly 
            340                 345                 350         


Leu Phe Phe Glu Asp Gln Arg Ile Asn Arg Phe Trp Ile His His Ile 
        355                 360                 365             


Glu Ser Ala Val Glu Arg Ile Leu Ala Ser Ile Asn Pro Glu Lys Leu 
    370                 375                 380                 


Tyr Lys Leu Arg Ile Gly Tyr Leu Gly Glu Lys Val Trp Lys Asp Leu 
385                 390                 395                 400 


Leu Asn Tyr Leu Ser Ile Lys Tyr Ile Ala Val Gly Lys Ala Val Phe 
                405                 410                 415     


His Phe Ala Met Glu Asp Leu Gly Lys Thr Gly Gln Asp Ile Glu Leu 
            420                 425                 430         


Gly Lys Leu Ser Asn Ser Val Ser Gly Gly Leu Thr Ser Phe Asp Tyr 
        435                 440                 445             


Glu Gln Ile Arg Ala Asp Glu Thr Leu Gln Arg Gln Leu Ser Val Glu 
    450                 455                 460                 


Val Ala Phe Ala Ala Asn Asn Leu Phe Arg Ala Val Val Gly Gln Thr 
465                 470                 475                 480 


Gly Lys Lys Ile Glu Gln Ser Lys Ser Glu Glu Asn Glu Glu Asp Phe 
                485                 490                 495     


Leu Leu Trp Lys Ala Glu Lys Ile Ala Glu Ser Ile Lys Lys Glu Gly 
            500                 505                 510         


Glu Gly Asn Thr Leu Lys Ser Ile Leu Gln Phe Phe Gly Gly Ala Ser 
        515                 520                 525             


Ser Trp Asp Leu Asn His Phe Cys Ala Ala Tyr Gly Asn Glu Ser Ser 
    530                 535                 540                 


Ala Leu Gly Tyr Glu Thr Lys Phe Ala Asp Asp Leu Arg Lys Ala Ile 
545                 550                 555                 560 


Tyr Ser Leu Arg Asn Glu Thr Phe His Phe Thr Thr Leu Asn Lys Gly 
                565                 570                 575     


Ser Phe Asp Trp Asn Ala Lys Leu Ile Gly Asp Met Phe Ser His Glu 
            580                 585                 590         


Ala Ala Thr Gly Ile Ala Val Glu Arg Thr Arg Phe Tyr Ser Asn Asn 
        595                 600                 605             


Leu Pro Met Phe Tyr Arg Glu Ser Asp Leu Lys Arg Ile Met Asp His 
    610                 615                 620                 


Leu Tyr Asn Thr Tyr His Pro Arg Ala Ser Gln Val Pro Ser Phe Asn 
625                 630                 635                 640 


Ser Val Phe Val Arg Lys Asn Phe Arg Leu Phe Leu Ser Asn Thr Leu 
                645                 650                 655     


Asn Thr Asn Thr Ser Phe Asp Thr Glu Val Tyr Gln Lys Trp Glu Ser 
            660                 665                 670         


Gly Val Tyr Tyr Leu Phe Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Pro 
        675                 680                 685             


Ser Gly Asp Ala His His Leu Phe Phe Glu Gly Leu Arg Arg Ile Arg 
    690                 695                 700                 


Lys Glu Ala Asp Asn Leu Pro Ile Val Gly Lys Glu Ala Lys Lys Arg 
705                 710                 715                 720 


Asn Ala Val Gln Asp Phe Gly Arg Arg Cys Asp Glu Leu Lys Asn Leu 
                725                 730                 735     


Ser Leu Ser Ala Ile Cys Gln Met Ile Met Thr Glu Tyr Asn Glu Gln 
            740                 745                 750         


Asn Asn Gly Asn Arg Lys Val Lys Ser Thr Arg Glu Asp Lys Arg Lys 
        755                 760                 765             


Pro Asp Ile Phe Gln His Tyr Lys Met Leu Leu Leu Arg Thr Leu Gln 
    770                 775                 780                 


Glu Ala Phe Ala Ile Tyr Ile Arg Arg Glu Glu Phe Lys Phe Ile Phe 
785                 790                 795                 800 


Asp Leu Pro Lys Thr Leu Tyr Val Met Lys Pro Val Glu Glu Phe Leu 
                805                 810                 815     


Pro Asn Trp Lys Ser Gly Met Phe Asp Ser Leu Val Glu Arg Val Lys 
            820                 825                 830         


Gln Ser Pro Asp Leu Gln Arg Trp Tyr Val Leu Cys Lys Phe Leu Asn 
        835                 840                 845             


Gly Arg Leu Leu Asn Gln Leu Ser Gly Val Ile Arg Ser Tyr Ile Gln 
    850                 855                 860                 


Phe Ala Gly Asp Ile Gln Arg Arg Ala Lys Ala Asn His Asn Arg Leu 
865                 870                 875                 880 


Tyr Met Asp Asn Thr Gln Arg Val Glu Tyr Tyr Ser Asn Val Leu Glu 
                885                 890                 895     


Val Val Asp Phe Cys Ile Lys Gly Thr Ser Arg Phe Ser Asn Val Phe 
            900                 905                 910         


Ser Asp Tyr Phe Arg Asp Glu Asp Ala Tyr Ala Asp Tyr Leu Asp Asn 
        915                 920                 925             


Tyr Leu Gln Phe Lys Asp Glu Lys Ile Ala Glu Val Ser Ser Phe Ala 
    930                 935                 940                 


Ala Leu Lys Thr Phe Cys Asn Glu Glu Glu Val Lys Ala Gly Ile Tyr 
945                 950                 955                 960 


Met Asp Gly Glu Asn Pro Val Met Gln Arg Asn Ile Val Met Ala Lys 
                965                 970                 975     


Leu Phe Gly Pro Asp Glu Val Leu Lys Asn Val Val Pro Lys Val Thr 
            980                 985                 990         


Arg Glu Glu Ile Glu Glu Tyr Tyr  Gln Leu Glu Lys Gln  Ile Ala Pro 
        995                 1000                 1005             


Tyr Arg  Gln Asn Gly Tyr Cys  Lys Ser Glu Glu Asp  Gln Lys Lys 
    1010                 1015                 1020             


Leu Leu  Arg Phe Gln Arg Ile  Lys Asn Arg Val Glu  Phe Gln Thr 
    1025                 1030                 1035             


Ile Thr  Glu Phe Ser Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu 
    1040                 1045                 1050             


Ile Ser  Trp Ser Phe Leu Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln 
    1055                 1060                 1065             


Leu Gly  Phe His Tyr Leu Cys  Leu His Asn Asp Thr  Glu Lys Pro 
    1070                 1075                 1080             


Ala Glu  Tyr Lys Glu Ile Ser  Arg Glu Asp Gly Thr  Val Ile Arg 
    1085                 1090                 1095             


Asn Ala  Ile Leu His Gln Val  Ala Ala Met Tyr Val  Gly Gly Leu 
    1100                 1105                 1110             


Pro Val  Tyr Thr Leu Ala Asp  Lys Lys Leu Ala Ala  Phe Glu Lys 
    1115                 1120                 1125             


Gly Glu  Ala Asp Cys Lys Leu  Ser Ile Ser Lys Asp  Thr Ala Gly 
    1130                 1135                 1140             


Ala Gly  Lys Lys Ile Lys Asp  Phe Phe Arg Tyr Ser  Lys Tyr Val 
    1145                 1150                 1155             


Leu Ile  Lys Asp Arg Met Leu  Thr Asp Gln Asn Gln  Lys Tyr Thr 
    1160                 1165                 1170             


Ile Tyr  Leu Ala Gly Leu Glu  Leu Phe Glu Asn Thr  Asp Glu His 
    1175                 1180                 1185             


Asp Asn  Ile Thr Asp Val Arg  Lys Tyr Val Asp His  Phe Lys Tyr 
    1190                 1195                 1200             


Tyr Ala  Thr Ser Asp Glu Asn  Ala Met Ser Ile Leu  Asp Leu Tyr 
    1205                 1210                 1215             


Ser Glu  Ile His Asp Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Gln 
    1220                 1225                 1230             


Lys Asn  Val Ala Asn Met Leu  Glu Asn Ile Leu Leu  Arg His Phe 
    1235                 1240                 1245             


Val Leu  Ile Arg Pro Glu Phe  Phe Thr Gly Ser Lys  Lys Val Gly 
    1250                 1255                 1260             


Glu Gly  Lys Lys Ile Thr Cys  Lys Ala Arg Ala Gln  Ile Glu Ile 
    1265                 1270                 1275             


Ala Glu  Asn Gly Met Arg Ser  Glu Asp Phe Thr Tyr  Lys Leu Ser 
    1280                 1285                 1290             


Asp Gly  Lys Lys Asn Ile Ser  Thr Cys Met Ile Ala  Ala Arg Asp 
    1295                 1300                 1305             


Gln Lys  Tyr Leu Asn Thr Val  Ala Arg Leu Leu Tyr  Tyr Pro His 
    1310                 1315                 1320             


Glu Ala  Lys Lys Ser Ile Val  Asp Thr Arg Glu Lys  Lys Asn Asn 
    1325                 1330                 1335             


Lys Lys  Thr Asn Arg Gly Asp  Gly Thr Phe Asn Lys  Gln Lys Gly 
    1340                 1345                 1350             


Thr Ala  Arg Lys Glu Lys Asp  Asn Gly Pro Arg Glu  Phe Asn Asp 
    1355                 1360                 1365             


Thr Gly  Phe Ser Asn Thr Pro  Phe Ala Gly Phe Asp  Pro Phe Arg 
    1370                 1375                 1380             


Asn Ser  
    1385 


<210>  329
<211>  1334
<212>  PRT
<213>  Artificial

<220>
<223>  CRISPR guide nucleic acid sequence

<400>  329

Met Lys Ile Ser Lys Val Asp His Thr Arg Met Ala Val Ala Lys Gly 
1               5                   10                  15      


Asn Gln His Arg Arg Asp Glu Ile Ser Gly Ile Leu Tyr Lys Asp Pro 
            20                  25                  30          


Thr Lys Thr Gly Ser Ile Asp Phe Asp Glu Arg Phe Lys Lys Leu Asn 
        35                  40                  45              


Cys Ser Ala Lys Ile Leu Tyr His Val Phe Asn Gly Ile Ala Glu Gly 
    50                  55                  60                  


Ser Asn Lys Tyr Lys Asn Ile Val Asp Lys Val Asn Asn Asn Leu Asp 
65                  70                  75                  80  


Arg Val Leu Phe Thr Gly Lys Ser Tyr Asp Arg Lys Ser Ile Ile Asp 
                85                  90                  95      


Ile Asp Thr Val Leu Arg Asn Val Glu Lys Ile Asn Ala Phe Asp Arg 
            100                 105                 110         


Ile Ser Thr Glu Glu Arg Glu Gln Ile Ile Asp Asp Leu Leu Glu Ile 
        115                 120                 125             


Gln Leu Arg Lys Gly Leu Arg Lys Gly Lys Ala Gly Leu Arg Glu Val 
    130                 135                 140                 


Leu Leu Ile Gly Ala Gly Val Ile Val Arg Thr Asp Lys Lys Gln Glu 
145                 150                 155                 160 


Ile Ala Asp Phe Leu Glu Ile Leu Asp Glu Asp Phe Asn Lys Thr Asn 
                165                 170                 175     


Gln Ala Lys Asn Ile Lys Leu Ser Ile Glu Asn Gln Gly Leu Val Val 
            180                 185                 190         


Ser Pro Val Ser Arg Gly Glu Glu Arg Ile Phe Asp Val Ser Gly Ala 
        195                 200                 205             


Gln Lys Gly Lys Ser Ser Lys Lys Ala Gln Glu Lys Glu Ala Leu Ser 
    210                 215                 220                 


Ala Phe Leu Leu Asp Tyr Ala Asp Leu Asp Lys Asn Val Arg Phe Glu 
225                 230                 235                 240 


Tyr Leu Arg Lys Ile Arg Arg Leu Ile Asn Leu Tyr Phe Tyr Val Lys 
                245                 250                 255     


Asn Asp Asp Val Met Ser Leu Thr Glu Ile Pro Ala Glu Val Asn Leu 
            260                 265                 270         


Glu Lys Asp Phe Asp Ile Trp Arg Asp His Glu Gln Arg Lys Glu Glu 
        275                 280                 285             


Asn Gly Asp Phe Val Gly Cys Pro Asp Ile Leu Leu Ala Asp Arg Asp 
    290                 295                 300                 


Val Lys Lys Ser Asn Ser Lys Gln Val Lys Ile Ala Glu Arg Gln Leu 
305                 310                 315                 320 


Arg Glu Ser Ile Arg Glu Lys Asn Ile Lys Arg Tyr Arg Phe Ser Ile 
                325                 330                 335     


Lys Thr Ile Glu Lys Asp Asp Gly Thr Tyr Phe Phe Ala Asn Lys Gln 
            340                 345                 350         


Ile Ser Val Phe Trp Ile His Arg Ile Glu Asn Ala Val Glu Arg Ile 
        355                 360                 365             


Leu Gly Ser Ile Asn Asp Lys Lys Leu Tyr Arg Leu Arg Leu Gly Tyr 
    370                 375                 380                 


Leu Gly Glu Lys Val Trp Lys Asp Ile Leu Asn Phe Leu Ser Ile Lys 
385                 390                 395                 400 


Tyr Ile Ala Val Gly Lys Ala Val Phe Asn Phe Ala Met Asp Asp Leu 
                405                 410                 415     


Gln Glu Lys Asp Arg Asp Ile Glu Pro Gly Lys Ile Ser Glu Asn Ala 
            420                 425                 430         


Val Asn Gly Leu Thr Ser Phe Asp Tyr Glu Gln Ile Lys Ala Asp Glu 
        435                 440                 445             


Met Leu Gln Arg Glu Val Ala Val Asn Val Ala Phe Ala Ala Asn Asn 
    450                 455                 460                 


Leu Ala Arg Val Thr Val Asp Ile Pro Gln Asn Gly Glu Lys Glu Asp 
465                 470                 475                 480 


Ile Leu Leu Trp Asn Lys Ser Asp Ile Lys Lys Tyr Lys Lys Asn Ser 
                485                 490                 495     


Lys Lys Gly Ile Leu Lys Ser Ile Leu Gln Phe Phe Gly Gly Ala Ser 
            500                 505                 510         


Thr Trp Asn Met Lys Met Phe Glu Ile Ala Tyr His Asp Gln Pro Gly 
        515                 520                 525             


Asp Tyr Glu Glu Asn Tyr Leu Tyr Asp Ile Ile Gln Ile Ile Tyr Ser 
    530                 535                 540                 


Leu Arg Asn Lys Ser Phe His Phe Lys Thr Tyr Asp His Gly Asp Lys 
545                 550                 555                 560 


Asn Trp Asn Arg Glu Leu Ile Gly Lys Met Ile Glu His Asp Ala Glu 
                565                 570                 575     


Arg Val Ile Ser Val Glu Arg Glu Lys Phe His Ser Asn Asn Leu Pro 
            580                 585                 590         


Met Phe Tyr Lys Asp Ala Asp Leu Lys Lys Ile Leu Asp Leu Leu Tyr 
        595                 600                 605             


Ser Asp Tyr Ala Gly Arg Ala Ser Gln Val Pro Ala Phe Asn Thr Val 
    610                 615                 620                 


Leu Val Arg Lys Asn Phe Pro Glu Phe Leu Arg Lys Asp Met Gly Tyr 
625                 630                 635                 640 


Lys Val His Phe Asn Asn Pro Glu Val Glu Asn Gln Trp His Ser Ala 
                645                 650                 655     


Val Tyr Tyr Leu Tyr Lys Glu Ile Tyr Tyr Asn Leu Phe Leu Arg Asp 
            660                 665                 670         


Lys Glu Val Lys Asn Leu Phe Tyr Thr Ser Leu Lys Asn Ile Arg Ser 
        675                 680                 685             


Glu Val Ser Asp Lys Lys Gln Lys Leu Ala Ser Asp Asp Phe Ala Ser 
    690                 695                 700                 


Arg Cys Glu Glu Ile Glu Asp Arg Ser Leu Pro Glu Ile Cys Gln Ile 
705                 710                 715                 720 


Ile Met Thr Glu Tyr Asn Ala Gln Asn Phe Gly Asn Arg Lys Val Lys 
                725                 730                 735     


Ser Gln Arg Val Ile Glu Lys Asn Lys Asp Ile Phe Arg His Tyr Lys 
            740                 745                 750         


Met Leu Leu Ile Lys Thr Leu Ala Gly Ala Phe Ser Leu Tyr Leu Lys 
        755                 760                 765             


Gln Glu Arg Phe Ala Phe Ile Gly Lys Ala Thr Pro Ile Pro Tyr Glu 
    770                 775                 780                 


Thr Thr Asp Val Lys Asn Phe Leu Pro Glu Trp Lys Ser Gly Met Tyr 
785                 790                 795                 800 


Ala Ser Phe Val Glu Glu Ile Lys Asn Asn Leu Asp Leu Gln Glu Trp 
                805                 810                 815     


Tyr Ile Val Gly Arg Phe Leu Asn Gly Arg Met Leu Asn Gln Leu Ala 
            820                 825                 830         


Gly Ser Leu Arg Ser Tyr Ile Gln Tyr Ala Glu Asp Ile Glu Arg Arg 
        835                 840                 845             


Ala Ala Glu Asn Arg Asn Lys Leu Phe Ser Lys Pro Asp Glu Lys Ile 
    850                 855                 860                 


Glu Ala Cys Lys Lys Ala Val Arg Val Leu Asp Leu Cys Ile Lys Ile 
865                 870                 875                 880 


Ser Thr Arg Ile Ser Ala Glu Phe Thr Asp Tyr Phe Asp Ser Glu Asp 
                885                 890                 895     


Asp Tyr Ala Asp Tyr Leu Glu Lys Tyr Leu Lys Tyr Gln Asp Asp Ala 
            900                 905                 910         


Ile Lys Glu Leu Ser Gly Ser Ser Tyr Ala Ala Leu Asp His Phe Cys 
        915                 920                 925             


Asn Lys Asp Asp Leu Lys Phe Asp Ile Tyr Val Asn Ala Gly Gln Lys 
    930                 935                 940                 


Pro Ile Leu Gln Arg Asn Ile Val Met Ala Lys Leu Phe Gly Pro Asp 
945                 950                 955                 960 


Asn Ile Leu Ser Glu Val Met Glu Lys Val Thr Glu Ser Ala Ile Arg 
                965                 970                 975     


Glu Tyr Tyr Asp Tyr Leu Lys Lys Val Ser Gly Tyr Arg Val Arg Gly 
            980                 985                 990         


Lys Cys Ser Thr Glu Lys Glu Gln  Glu Asp Leu Leu Lys  Phe Gln Arg 
        995                 1000                 1005             


Leu Lys  Asn Ala Val Glu Phe  Arg Asp Val Thr Glu  Tyr Ala Glu 
    1010                 1015                 1020             


Val Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Ser Trp  Ser Tyr Leu 
    1025                 1030                 1035             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Met 
    1040                 1045                 1050             


Cys Leu  Lys Asn Lys Ser Phe  Lys Pro Ala Glu Tyr  Val Asp Ile 
    1055                 1060                 1065             


Arg Arg  Asn Asn Gly Thr Ile  Ile His Asn Ala Ile  Leu Tyr Gln 
    1070                 1075                 1080             


Ile Val  Ser Met Tyr Ile Asn  Gly Leu Asp Phe Tyr  Ser Cys Asp 
    1085                 1090                 1095             


Lys Glu  Gly Lys Thr Leu Lys  Pro Ile Glu Thr Gly  Lys Gly Val 
    1100                 1105                 1110             


Gly Ser  Lys Ile Gly Gln Phe  Ile Lys Tyr Ser Gln  Tyr Leu Tyr 
    1115                 1120                 1125             


Asn Asp  Pro Ser Tyr Lys Leu  Glu Ile Tyr Asn Ala  Gly Leu Glu 
    1130                 1135                 1140             


Val Phe  Glu Asn Ile Asp Glu  His Asp Asn Ile Thr  Asp Leu Arg 
    1145                 1150                 1155             


Lys Tyr  Val Asp His Phe Lys  Tyr Tyr Ala Tyr Gly  Asn Lys Met 
    1160                 1165                 1170             


Ser Leu  Leu Asp Leu Tyr Ser  Glu Phe Phe Asp Arg  Phe Phe Thr 
    1175                 1180                 1185             


Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Val Asn Val  Leu Glu Asn 
    1190                 1195                 1200             


Ile Leu  Leu Arg His Phe Val  Ile Phe Tyr Pro Lys  Phe Gly Ser 
    1205                 1210                 1215             


Gly Lys  Lys Asp Val Gly Ile  Arg Asp Cys Lys Lys  Glu Arg Ala 
    1220                 1225                 1230             


Gln Ile  Glu Ile Ser Glu Gln  Ser Leu Thr Ser Glu  Asp Phe Met 
    1235                 1240                 1245             


Phe Lys  Leu Asp Asp Lys Ala  Gly Glu Glu Ala Lys  Lys Phe Pro 
    1250                 1255                 1260             


Ala Arg  Asp Glu Arg Tyr Leu  Gln Thr Ile Ala Lys  Leu Leu Tyr 
    1265                 1270                 1275             


Tyr Pro  Asn Glu Ile Glu Asp  Met Asn Arg Phe Met  Lys Lys Gly 
    1280                 1285                 1290             


Glu Thr  Ile Asn Lys Lys Val  Gln Phe Asn Arg Lys  Lys Lys Ile 
    1295                 1300                 1305             


Thr Arg  Lys Gln Lys Asn Asn  Ser Ser Asn Glu Val  Leu Ser Ser 
    1310                 1315                 1320             


Thr Met  Gly Tyr Leu Phe Lys  Asn Ile Lys Leu 
    1325                 1330                 


<210>  330
<211>  1175
<212>  PRT
<213>  Carnobacterium gallinarum

<400>  330

Met Arg Ile Thr Lys Val Lys Ile Lys Leu Asp Asn Lys Leu Tyr Gln 
1               5                   10                  15      


Val Thr Met Gln Lys Glu Glu Lys Tyr Gly Thr Leu Lys Leu Asn Glu 
            20                  25                  30          


Glu Ser Arg Lys Ser Thr Ala Glu Ile Leu Arg Leu Lys Lys Ala Ser 
        35                  40                  45              


Phe Asn Lys Ser Phe His Ser Lys Thr Ile Asn Ser Gln Lys Glu Asn 
    50                  55                  60                  


Lys Asn Ala Thr Ile Lys Lys Asn Gly Asp Tyr Ile Ser Gln Ile Phe 
65                  70                  75                  80  


Glu Lys Leu Val Gly Val Asp Thr Asn Lys Asn Ile Arg Lys Pro Lys 
                85                  90                  95      


Met Ser Leu Thr Asp Leu Lys Asp Leu Pro Lys Lys Asp Leu Ala Leu 
            100                 105                 110         


Phe Ile Lys Arg Lys Phe Lys Asn Asp Asp Ile Val Glu Ile Lys Asn 
        115                 120                 125             


Leu Asp Leu Ile Ser Leu Phe Tyr Asn Ala Leu Gln Lys Val Pro Gly 
    130                 135                 140                 


Glu His Phe Thr Asp Glu Ser Trp Ala Asp Phe Cys Gln Glu Met Met 
145                 150                 155                 160 


Pro Tyr Arg Glu Tyr Lys Asn Lys Phe Ile Glu Arg Lys Ile Ile Leu 
                165                 170                 175     


Leu Ala Asn Ser Ile Glu Gln Asn Lys Gly Phe Ser Ile Asn Pro Glu 
            180                 185                 190         


Thr Phe Ser Lys Arg Lys Arg Val Leu His Gln Trp Ala Ile Glu Val 
        195                 200                 205             


Gln Glu Arg Gly Asp Phe Ser Ile Leu Asp Glu Lys Leu Ser Lys Leu 
    210                 215                 220                 


Ala Glu Ile Tyr Asn Phe Lys Lys Met Cys Lys Arg Val Gln Asp Glu 
225                 230                 235                 240 


Leu Asn Asp Leu Glu Lys Ser Met Lys Lys Gly Lys Asn Pro Glu Lys 
                245                 250                 255     


Glu Lys Glu Ala Tyr Lys Lys Gln Lys Asn Phe Lys Ile Lys Thr Ile 
            260                 265                 270         


Trp Lys Asp Tyr Pro Tyr Lys Thr His Ile Gly Leu Ile Glu Lys Ile 
        275                 280                 285             


Lys Glu Asn Glu Glu Leu Asn Gln Phe Asn Ile Glu Ile Gly Lys Tyr 
    290                 295                 300                 


Phe Glu His Tyr Phe Pro Ile Lys Lys Glu Arg Cys Thr Glu Asp Glu 
305                 310                 315                 320 


Pro Tyr Tyr Leu Asn Ser Glu Thr Ile Ala Thr Thr Val Asn Tyr Gln 
                325                 330                 335     


Leu Lys Asn Ala Leu Ile Ser Tyr Leu Met Gln Ile Gly Lys Tyr Lys 
            340                 345                 350         


Gln Phe Gly Leu Glu Asn Gln Val Leu Asp Ser Lys Lys Leu Gln Glu 
        355                 360                 365             


Ile Gly Ile Tyr Glu Gly Phe Gln Thr Lys Phe Met Asp Ala Cys Val 
    370                 375                 380                 


Phe Ala Thr Ser Ser Leu Lys Asn Ile Ile Glu Pro Met Arg Ser Gly 
385                 390                 395                 400 


Asp Ile Leu Gly Lys Arg Glu Phe Lys Glu Ala Ile Ala Thr Ser Ser 
                405                 410                 415     


Phe Val Asn Tyr His His Phe Phe Pro Tyr Phe Pro Phe Glu Leu Lys 
            420                 425                 430         


Gly Met Lys Asp Arg Glu Ser Glu Leu Ile Pro Phe Gly Glu Gln Thr 
        435                 440                 445             


Glu Ala Lys Gln Met Gln Asn Ile Trp Ala Leu Arg Gly Ser Val Gln 
    450                 455                 460                 


Gln Ile Arg Asn Glu Ile Phe His Ser Phe Asp Lys Asn Gln Lys Phe 
465                 470                 475                 480 


Asn Leu Pro Gln Leu Asp Lys Ser Asn Phe Glu Phe Asp Ala Ser Glu 
                485                 490                 495     


Asn Ser Thr Gly Lys Ser Gln Ser Tyr Ile Glu Thr Asp Tyr Lys Phe 
            500                 505                 510         


Leu Phe Glu Ala Glu Lys Asn Gln Leu Glu Gln Phe Phe Ile Glu Arg 
        515                 520                 525             


Ile Lys Ser Ser Gly Ala Leu Glu Tyr Tyr Pro Leu Lys Ser Leu Glu 
    530                 535                 540                 


Lys Leu Phe Ala Lys Lys Glu Met Lys Phe Ser Leu Gly Ser Gln Val 
545                 550                 555                 560 


Val Ala Phe Ala Pro Ser Tyr Lys Lys Leu Val Lys Lys Gly His Ser 
                565                 570                 575     


Tyr Gln Thr Ala Thr Glu Gly Thr Ala Asn Tyr Leu Gly Leu Ser Tyr 
            580                 585                 590         


Tyr Asn Arg Tyr Glu Leu Lys Glu Glu Ser Phe Gln Ala Gln Tyr Tyr 
        595                 600                 605             


Leu Leu Lys Leu Ile Tyr Gln Tyr Val Phe Leu Pro Asn Phe Ser Gln 
    610                 615                 620                 


Gly Asn Ser Pro Ala Phe Arg Glu Thr Val Lys Ala Ile Leu Arg Ile 
625                 630                 635                 640 


Asn Lys Asp Glu Ala Arg Lys Lys Met Lys Lys Asn Lys Lys Phe Leu 
                645                 650                 655     


Arg Lys Tyr Ala Phe Glu Gln Val Arg Glu Met Glu Phe Lys Glu Thr 
            660                 665                 670         


Pro Asp Gln Tyr Met Ser Tyr Leu Gln Ser Glu Met Arg Glu Glu Lys 
        675                 680                 685             


Val Arg Lys Ala Glu Lys Asn Asp Lys Gly Phe Glu Lys Asn Ile Thr 
    690                 695                 700                 


Met Asn Phe Glu Lys Leu Leu Met Gln Ile Phe Val Lys Gly Phe Asp 
705                 710                 715                 720 


Val Phe Leu Thr Thr Phe Ala Gly Lys Glu Leu Leu Leu Ser Ser Glu 
                725                 730                 735     


Glu Lys Val Ile Lys Glu Thr Glu Ile Ser Leu Ser Lys Lys Ile Asn 
            740                 745                 750         


Glu Arg Glu Lys Thr Leu Lys Ala Ser Ile Gln Val Glu His Gln Leu 
        755                 760                 765             


Val Ala Thr Asn Ser Ala Ile Ser Tyr Trp Leu Phe Cys Lys Leu Leu 
    770                 775                 780                 


Asp Ser Arg His Leu Asn Glu Leu Arg Asn Glu Met Ile Lys Phe Lys 
785                 790                 795                 800 


Gln Ser Arg Ile Lys Phe Asn His Thr Gln His Ala Glu Leu Ile Gln 
                805                 810                 815     


Asn Leu Leu Pro Ile Val Glu Leu Thr Ile Leu Ser Asn Asp Tyr Asp 
            820                 825                 830         


Glu Lys Asn Asp Ser Gln Asn Val Asp Val Ser Ala Tyr Phe Glu Asp 
        835                 840                 845             


Lys Ser Leu Tyr Glu Thr Ala Pro Tyr Val Gln Thr Asp Asp Arg Thr 
    850                 855                 860                 


Arg Val Ser Phe Arg Pro Ile Leu Lys Leu Glu Lys Tyr His Thr Lys 
865                 870                 875                 880 


Ser Leu Ile Glu Ala Leu Leu Lys Asp Asn Pro Gln Phe Arg Val Ala 
                885                 890                 895     


Ala Thr Asp Ile Gln Glu Trp Met His Lys Arg Glu Glu Ile Gly Glu 
            900                 905                 910         


Leu Val Glu Lys Arg Lys Asn Leu His Thr Glu Trp Ala Glu Gly Gln 
        915                 920                 925             


Gln Thr Leu Gly Ala Glu Lys Arg Glu Glu Tyr Arg Asp Tyr Cys Lys 
    930                 935                 940                 


Lys Ile Asp Arg Phe Asn Trp Lys Ala Asn Lys Val Thr Leu Thr Tyr 
945                 950                 955                 960 


Leu Ser Gln Leu His Tyr Leu Ile Thr Asp Leu Leu Gly Arg Met Val 
                965                 970                 975     


Gly Phe Ser Ala Leu Phe Glu Arg Asp Leu Val Tyr Phe Ser Arg Ser 
            980                 985                 990         


Phe Ser Glu Leu Gly Gly Glu Thr  Tyr His Ile Ser Asp  Tyr Lys Asn 
        995                 1000                 1005             


Leu Ser  Gly Val Leu Arg Leu  Asn Ala Glu Val Lys  Pro Ile Lys 
    1010                 1015                 1020             


Ile Lys  Asn Ile Lys Val Ile  Asp Asn Glu Glu Asn  Pro Tyr Lys 
    1025                 1030                 1035             


Gly Asn  Glu Pro Glu Val Lys  Pro Phe Leu Asp Arg  Leu His Ala 
    1040                 1045                 1050             


Tyr Leu  Glu Asn Val Ile Gly  Ile Lys Ala Val His  Gly Lys Ile 
    1055                 1060                 1065             


Arg Asn  Gln Thr Ala His Leu  Ser Val Leu Gln Leu  Glu Leu Ser 
    1070                 1075                 1080             


Met Ile  Glu Ser Met Asn Asn  Leu Arg Asp Leu Met  Ala Tyr Asp 
    1085                 1090                 1095             


Arg Lys  Leu Lys Asn Ala Val  Thr Lys Ser Met Ile  Lys Ile Leu 
    1100                 1105                 1110             


Asp Lys  His Gly Met Ile Leu  Lys Leu Lys Ile Asp  Glu Asn His 
    1115                 1120                 1125             


Lys Asn  Phe Glu Ile Glu Ser  Leu Ile Pro Lys Glu  Ile Ile His 
    1130                 1135                 1140             


Leu Lys  Asp Lys Ala Ile Lys  Thr Asn Gln Val Ser  Glu Glu Tyr 
    1145                 1150                 1155             


Cys Gln  Leu Val Leu Ala Leu  Leu Thr Thr Asn Pro  Gly Asn Gln 
    1160                 1165                 1170             


Leu Asn  
    1175 


<210>  331
<211>  1154
<212>  PRT
<213>  Paludibacter propionicigenes

<400>  331

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Ser Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Thr Leu Asn Lys Thr Ile Ile Lys Phe Asp 
    50                  55                  60                  


Thr Ala Lys Lys Gln Lys Leu Asn Val Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Lys Ala 
                85                  90                  95      


Glu Glu Ile Leu Pro Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Gln Ala Gln Asp Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Ala Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Lys Met Leu Gln Asp Val Lys Pro Leu Thr Asp Asp Lys Gly Lys Ile 
    210                 215                 220                 


Asn Thr Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Val Pro Asn Glu Ala Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ala His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr 
        355                 360                 365             


Asn Asp Ile Leu Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp 
    370                 375                 380                 


Asn Thr Asn Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Gly Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Lys Thr Val Phe Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Arg Phe 
    450                 455                 460                 


Ile Asn Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Val Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Gln Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ser Tyr Asn Ala Arg Tyr Phe Met Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Gly Phe Thr Thr Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys 
            580                 585                 590         


Gln Ala Glu Lys Val Asn Pro Arg Lys Lys Glu Ala Tyr Ala Phe Glu 
        595                 600                 605             


Ala Val Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala 
    610                 615                 620                 


Tyr Val Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys 
625                 630                 635                 640 


Val Ala Glu Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val 
                645                 650                 655     


Phe Ile Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe 
            660                 665                 670         


Val Gln Met Pro Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln 
        675                 680                 685             


Lys Ala Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys 
    690                 695                 700                 


Lys Leu Thr Pro Gln Tyr Ala Lys Ala Asp Asp Ala Thr His Ile Ala 
705                 710                 715                 720 


Phe Tyr Val Phe Cys Lys Leu Leu Asp Ala Ala His Leu Ser Asn Leu 
                725                 730                 735     


Arg Asn Glu Leu Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe 
            740                 745                 750         


His His Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val 
        755                 760                 765             


Val Pro Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu 
    770                 775                 780                 


Ala Arg Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp 
785                 790                 795                 800 


Ser Asp Leu Phe Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala 
                805                 810                 815     


Asn Ile Glu Leu Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln 
            820                 825                 830         


Ile Ile Asn Lys Asp Thr Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr 
        835                 840                 845             


Ala Trp Asn Thr Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg 
    850                 855                 860                 


Glu Asp His His Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys 
865                 870                 875                 880 


Glu Lys Gln Glu Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe 
                885                 890                 895     


Ile Glu Lys His Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn 
            900                 905                 910         


Thr Tyr Asn Trp Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg 
        915                 920                 925             


Leu His Gly Leu Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val 
    930                 935                 940                 


Ala Leu Phe Asp Arg Asp Phe Gln Phe Phe Asp Glu Gln Gln Ile Ala 
945                 950                 955                 960 


Asp Glu Phe Lys Leu His Gly Phe Val Asn Leu His Ser Ile Asp Lys 
                965                 970                 975     


Lys Leu Asn Glu Val Pro Thr Lys Lys Ile Lys Glu Ile Tyr Asp Ile 
            980                 985                 990         


Arg Asn Lys Ile Ile Gln Ile Asn  Gly Asn Lys Ile Asn  Glu Ser Val 
        995                 1000                 1005             


Arg Ala  Asn Leu Ile Gln Phe  Ile Ser Ser Lys Arg  Asn Tyr Tyr 
    1010                 1015                 1020             


Asn Asn  Ala Phe Leu His Val  Ser Asn Asp Glu Ile  Lys Glu Lys 
    1025                 1030                 1035             


Gln Met  Tyr Asp Ile Arg Asn  His Ile Ala His Phe  Asn Tyr Leu 
    1040                 1045                 1050             


Thr Lys  Asp Ala Ala Asp Phe  Ser Leu Ile Asp Leu  Ile Asn Glu 
    1055                 1060                 1065             


Leu Arg  Glu Leu Leu His Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1070                 1075                 1080             


Ser Lys  Ala Phe Ile Asp Leu  Phe Asp Lys His Gly  Met Ile Leu 
    1085                 1090                 1095             


Lys Leu  Lys Leu Asn Ala Asp  His Lys Leu Lys Val  Glu Ser Leu 
    1100                 1105                 1110             


Glu Pro  Lys Lys Ile Tyr His  Leu Gly Ser Ser Ala  Lys Asp Lys 
    1115                 1120                 1125             


Pro Glu  Tyr Gln Tyr Cys Thr  Asn Gln Val Met Met  Ala Tyr Cys 
    1130                 1135                 1140             


Asn Met  Cys Arg Ser Leu Leu  Glu Met Lys Lys 
    1145                 1150                 


<210>  332
<211>  1120
<212>  PRT
<213>  Listeria seeligeri

<400>  332

Met Trp Ile Ser Ile Lys Thr Leu Ile His His Leu Gly Val Leu Phe 
1               5                   10                  15      


Phe Cys Asp Tyr Met Tyr Asn Arg Arg Glu Lys Lys Ile Ile Glu Val 
            20                  25                  30          


Lys Thr Met Arg Ile Thr Lys Val Glu Val Asp Arg Lys Lys Val Leu 
        35                  40                  45              


Ile Ser Arg Asp Lys Asn Gly Gly Lys Leu Val Tyr Glu Asn Glu Met 
    50                  55                  60                  


Gln Asp Asn Thr Glu Gln Ile Met His His Lys Lys Ser Ser Phe Tyr 
65                  70                  75                  80  


Lys Ser Val Val Asn Lys Thr Ile Cys Arg Pro Glu Gln Lys Gln Met 
                85                  90                  95      


Lys Lys Leu Val His Gly Leu Leu Gln Glu Asn Ser Gln Glu Lys Ile 
            100                 105                 110         


Lys Val Ser Asp Val Thr Lys Leu Asn Ile Ser Asn Phe Leu Asn His 
        115                 120                 125             


Arg Phe Lys Lys Ser Leu Tyr Tyr Phe Pro Glu Asn Ser Pro Asp Lys 
    130                 135                 140                 


Ser Glu Glu Tyr Arg Ile Glu Ile Asn Leu Ser Gln Leu Leu Glu Asp 
145                 150                 155                 160 


Ser Leu Lys Lys Gln Gln Gly Thr Phe Ile Cys Trp Glu Ser Phe Ser 
                165                 170                 175     


Lys Asp Met Glu Leu Tyr Ile Asn Trp Ala Glu Asn Tyr Ile Ser Ser 
            180                 185                 190         


Lys Thr Lys Leu Ile Lys Lys Ser Ile Arg Asn Asn Arg Ile Gln Ser 
        195                 200                 205             


Thr Glu Ser Arg Ser Gly Gln Leu Met Asp Arg Tyr Met Lys Asp Ile 
    210                 215                 220                 


Leu Asn Lys Asn Lys Pro Phe Asp Ile Gln Ser Val Ser Glu Lys Tyr 
225                 230                 235                 240 


Gln Leu Glu Lys Leu Thr Ser Ala Leu Lys Ala Thr Phe Lys Glu Ala 
                245                 250                 255     


Lys Lys Asn Asp Lys Glu Ile Asn Tyr Lys Leu Lys Ser Thr Leu Gln 
            260                 265                 270         


Asn His Glu Arg Gln Ile Ile Glu Glu Leu Lys Glu Asn Ser Glu Leu 
        275                 280                 285             


Asn Gln Phe Asn Ile Glu Ile Arg Lys His Leu Glu Thr Tyr Phe Pro 
    290                 295                 300                 


Ile Lys Lys Thr Asn Arg Lys Val Gly Asp Ile Arg Asn Leu Glu Ile 
305                 310                 315                 320 


Gly Glu Ile Gln Lys Ile Val Asn His Arg Leu Lys Asn Lys Ile Val 
                325                 330                 335     


Gln Arg Ile Leu Gln Glu Gly Lys Leu Ala Ser Tyr Glu Ile Glu Ser 
            340                 345                 350         


Thr Val Asn Ser Asn Ser Leu Gln Lys Ile Lys Ile Glu Glu Ala Phe 
        355                 360                 365             


Ala Leu Lys Phe Ile Asn Ala Cys Leu Phe Ala Ser Asn Asn Leu Arg 
    370                 375                 380                 


Asn Met Val Tyr Pro Val Cys Lys Lys Asp Ile Leu Met Ile Gly Glu 
385                 390                 395                 400 


Phe Lys Asn Ser Phe Lys Glu Ile Lys His Lys Lys Phe Ile Arg Gln 
                405                 410                 415     


Trp Ser Gln Phe Phe Ser Gln Glu Ile Thr Val Asp Asp Ile Glu Leu 
            420                 425                 430         


Ala Ser Trp Gly Leu Arg Gly Ala Ile Ala Pro Ile Arg Asn Glu Ile 
        435                 440                 445             


Ile His Leu Lys Lys His Ser Trp Lys Lys Phe Phe Asn Asn Pro Thr 
    450                 455                 460                 


Phe Lys Val Lys Lys Ser Lys Ile Ile Asn Gly Lys Thr Lys Asp Val 
465                 470                 475                 480 


Thr Ser Glu Phe Leu Tyr Lys Glu Thr Leu Phe Lys Asp Tyr Phe Tyr 
                485                 490                 495     


Ser Glu Leu Asp Ser Val Pro Glu Leu Ile Ile Asn Lys Met Glu Ser 
            500                 505                 510         


Ser Lys Ile Leu Asp Tyr Tyr Ser Ser Asp Gln Leu Asn Gln Val Phe 
        515                 520                 525             


Thr Ile Pro Asn Phe Glu Leu Ser Leu Leu Thr Ser Ala Val Pro Phe 
    530                 535                 540                 


Ala Pro Ser Phe Lys Arg Val Tyr Leu Lys Gly Phe Asp Tyr Gln Asn 
545                 550                 555                 560 


Gln Asp Glu Ala Gln Pro Asp Tyr Asn Leu Lys Leu Asn Ile Tyr Asn 
                565                 570                 575     


Glu Lys Ala Phe Asn Ser Glu Ala Phe Gln Ala Gln Tyr Ser Leu Phe 
            580                 585                 590         


Lys Met Val Tyr Tyr Gln Val Phe Leu Pro Gln Phe Thr Thr Asn Asn 
        595                 600                 605             


Asp Leu Phe Lys Ser Ser Val Asp Phe Ile Leu Thr Leu Asn Lys Glu 
    610                 615                 620                 


Arg Lys Gly Tyr Ala Lys Ala Phe Gln Asp Ile Arg Lys Met Asn Lys 
625                 630                 635                 640 


Asp Glu Lys Pro Ser Glu Tyr Met Ser Tyr Ile Gln Ser Gln Leu Met 
                645                 650                 655     


Leu Tyr Gln Lys Lys Gln Glu Glu Lys Glu Lys Ile Asn His Phe Glu 
            660                 665                 670         


Lys Phe Ile Asn Gln Val Phe Ile Lys Gly Phe Asn Ser Phe Ile Glu 
        675                 680                 685             


Lys Asn Arg Leu Thr Tyr Ile Cys His Pro Thr Lys Asn Thr Val Pro 
    690                 695                 700                 


Glu Asn Asp Asn Ile Glu Ile Pro Phe His Thr Asp Met Asp Asp Ser 
705                 710                 715                 720 


Asn Ile Ala Phe Trp Leu Met Cys Lys Leu Leu Asp Ala Lys Gln Leu 
                725                 730                 735     


Ser Glu Leu Arg Asn Glu Met Ile Lys Phe Ser Cys Ser Leu Gln Ser 
            740                 745                 750         


Thr Glu Glu Ile Ser Thr Phe Thr Lys Ala Arg Glu Val Ile Gly Leu 
        755                 760                 765             


Ala Leu Leu Asn Gly Glu Lys Gly Cys Asn Asp Trp Lys Glu Leu Phe 
    770                 775                 780                 


Asp Asp Lys Glu Ala Trp Lys Lys Asn Met Ser Leu Tyr Val Ser Glu 
785                 790                 795                 800 


Glu Leu Leu Gln Ser Leu Pro Tyr Thr Gln Glu Asp Gly Gln Thr Pro 
                805                 810                 815     


Val Ile Asn Arg Ser Ile Asp Leu Val Lys Lys Tyr Gly Thr Glu Thr 
            820                 825                 830         


Ile Leu Glu Lys Leu Phe Ser Ser Ser Asp Asp Tyr Lys Val Ser Ala 
        835                 840                 845             


Lys Asp Ile Ala Lys Leu His Glu Tyr Asp Val Thr Glu Lys Ile Ala 
    850                 855                 860                 


Gln Gln Glu Ser Leu His Lys Gln Trp Ile Glu Lys Pro Gly Leu Ala 
865                 870                 875                 880 


Arg Asp Ser Ala Trp Thr Lys Lys Tyr Gln Asn Val Ile Asn Asp Ile 
                885                 890                 895     


Ser Asn Tyr Gln Trp Ala Lys Thr Lys Val Glu Leu Thr Gln Val Arg 
            900                 905                 910         


His Leu His Gln Leu Thr Ile Asp Leu Leu Ser Arg Leu Ala Gly Tyr 
        915                 920                 925             


Met Ser Ile Ala Asp Arg Asp Phe Gln Phe Ser Ser Asn Tyr Ile Leu 
    930                 935                 940                 


Glu Arg Glu Asn Ser Glu Tyr Arg Val Thr Ser Trp Ile Leu Leu Ser 
945                 950                 955                 960 


Glu Asn Lys Asn Lys Asn Lys Tyr Asn Asp Tyr Glu Leu Tyr Asn Leu 
                965                 970                 975     


Lys Asn Ala Ser Ile Lys Val Ser Ser Lys Asn Asp Pro Gln Leu Lys 
            980                 985                 990         


Val Asp Leu Lys Gln Leu Arg Leu  Thr Leu Glu Tyr Leu  Glu Leu Phe 
        995                 1000                 1005             


Asp Asn  Arg Leu Lys Glu Lys  Arg Asn Asn Ile Ser  His Phe Asn 
    1010                 1015                 1020             


Tyr Leu  Asn Gly Gln Leu Gly  Asn Ser Ile Leu Glu  Leu Phe Asp 
    1025                 1030                 1035             


Asp Ala  Arg Asp Val Leu Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1040                 1045                 1050             


Val Ser  Lys Ser Leu Lys Glu  Ile Leu Ser Ser His  Gly Met Glu 
    1055                 1060                 1065             


Val Thr  Phe Lys Pro Leu Tyr  Gln Thr Asn His His  Leu Lys Ile 
    1070                 1075                 1080             


Asp Lys  Leu Gln Pro Lys Lys  Ile His His Leu Gly  Glu Lys Ser 
    1085                 1090                 1095             


Thr Val  Ser Ser Asn Gln Val  Ser Asn Glu Tyr Cys  Gln Leu Val 
    1100                 1105                 1110             


Arg Thr  Leu Leu Thr Met Lys  
    1115                 1120 


<210>  333
<211>  1051
<212>  PRT
<213>  Listeria newyorkensis

<400>  333

Met Lys Ile Thr Lys Met Arg Val Asp Gly Arg Thr Ile Val Met Glu 
1               5                   10                  15      


Arg Thr Ser Lys Glu Gly Gln Leu Gly Tyr Glu Gly Ile Asp Gly Asn 
            20                  25                  30          


Lys Thr Thr Glu Ile Ile Phe Asp Lys Lys Lys Glu Ser Phe Tyr Lys 
        35                  40                  45              


Ser Ile Leu Asn Lys Thr Val Arg Lys Pro Asp Glu Lys Glu Lys Asn 
    50                  55                  60                  


Arg Arg Lys Gln Ala Ile Asn Lys Ala Ile Asn Lys Glu Ile Thr Glu 
65                  70                  75                  80  


Leu Met Leu Ala Val Leu His Gln Glu Val Pro Ser Gln Lys Leu His 
                85                  90                  95      


Asn Leu Lys Ser Leu Asn Thr Glu Ser Leu Thr Lys Leu Phe Lys Pro 
            100                 105                 110         


Lys Phe Gln Asn Met Ile Ser Tyr Pro Pro Ser Lys Gly Ala Glu His 
        115                 120                 125             


Val Gln Phe Cys Leu Thr Asp Ile Ala Val Pro Ala Ile Arg Asp Leu 
    130                 135                 140                 


Asp Glu Ile Lys Pro Asp Trp Gly Ile Phe Phe Glu Lys Leu Lys Pro 
145                 150                 155                 160 


Tyr Thr Asp Trp Ala Glu Ser Tyr Ile His Tyr Lys Gln Thr Thr Ile 
                165                 170                 175     


Gln Lys Ser Ile Glu Gln Asn Lys Ile Gln Ser Pro Asp Ser Pro Arg 
            180                 185                 190         


Lys Leu Val Leu Gln Lys Tyr Val Thr Ala Phe Leu Asn Gly Glu Pro 
        195                 200                 205             


Leu Gly Leu Asp Leu Val Ala Lys Lys Tyr Lys Leu Ala Asp Leu Ala 
    210                 215                 220                 


Glu Ser Phe Lys Leu Val Asp Leu Asn Glu Asp Lys Ser Ala Asn Tyr 
225                 230                 235                 240 


Lys Ile Lys Ala Cys Leu Gln Gln His Gln Arg Asn Ile Leu Asp Glu 
                245                 250                 255     


Leu Lys Glu Asp Pro Glu Leu Asn Gln Tyr Gly Ile Glu Val Lys Lys 
            260                 265                 270         


Tyr Ile Gln Arg Tyr Phe Pro Ile Lys Arg Ala Pro Asn Arg Ser Lys 
        275                 280                 285             


His Ala Arg Ala Asp Phe Leu Lys Lys Glu Leu Ile Glu Ser Thr Val 
    290                 295                 300                 


Glu Gln Gln Phe Lys Asn Ala Val Tyr His Tyr Val Leu Glu Gln Gly 
305                 310                 315                 320 


Lys Met Glu Ala Tyr Glu Leu Thr Asp Pro Lys Thr Lys Asp Leu Gln 
                325                 330                 335     


Asp Ile Arg Ser Gly Glu Ala Phe Ser Phe Lys Phe Ile Asn Ala Cys 
            340                 345                 350         


Ala Phe Ala Ser Asn Asn Leu Lys Met Ile Leu Asn Pro Glu Cys Glu 
        355                 360                 365             


Lys Asp Ile Leu Gly Lys Gly Asn Phe Lys Lys Asn Leu Pro Asn Ser 
    370                 375                 380                 


Thr Thr Arg Ser Asp Val Val Lys Lys Met Ile Pro Phe Phe Ser Asp 
385                 390                 395                 400 


Glu Leu Gln Asn Val Asn Phe Asp Glu Ala Ile Trp Ala Ile Arg Gly 
                405                 410                 415     


Ser Ile Gln Gln Ile Arg Asn Glu Val Tyr His Cys Lys Lys His Ser 
            420                 425                 430         


Trp Lys Ser Ile Leu Lys Ile Lys Gly Phe Glu Phe Glu Pro Asn Asn 
        435                 440                 445             


Met Lys Tyr Ala Asp Ser Asp Met Gln Lys Leu Met Asp Lys Asp Ile 
    450                 455                 460                 


Ala Lys Ile Pro Glu Phe Ile Glu Glu Lys Leu Lys Ser Ser Gly Val 
465                 470                 475                 480 


Val Arg Phe Tyr Arg His Asp Glu Leu Gln Ser Ile Trp Glu Met Lys 
                485                 490                 495     


Gln Gly Phe Ser Leu Leu Thr Thr Asn Ala Pro Phe Val Pro Ser Phe 
            500                 505                 510         


Lys Arg Val Tyr Ala Lys Gly His Asp Tyr Gln Thr Ser Lys Asn Arg 
        515                 520                 525             


Tyr Tyr Asn Leu Asp Leu Thr Thr Phe Asp Ile Leu Glu Tyr Gly Glu 
    530                 535                 540                 


Glu Asp Phe Arg Ala Arg Tyr Phe Leu Thr Lys Leu Val Tyr Tyr Gln 
545                 550                 555                 560 


Gln Phe Met Pro Trp Phe Thr Ala Asp Asn Asn Ala Phe Arg Asp Ala 
                565                 570                 575     


Ala Asn Phe Val Leu Arg Leu Asn Lys Asn Arg Gln Gln Asp Ala Lys 
            580                 585                 590         


Ala Phe Ile Asn Ile Arg Glu Val Glu Glu Gly Glu Met Pro Arg Asp 
        595                 600                 605             


Tyr Met Gly Tyr Val Gln Gly Gln Ile Ala Ile His Glu Asp Ser Ile 
    610                 615                 620                 


Glu Asp Thr Pro Asn His Phe Glu Lys Phe Ile Ser Gln Val Phe Ile 
625                 630                 635                 640 


Lys Gly Phe Asp Arg His Met Arg Ser Ala Asn Leu Lys Phe Ile Lys 
                645                 650                 655     


Asn Pro Arg Asn Gln Gly Leu Glu Gln Ser Glu Ile Glu Glu Met Ser 
            660                 665                 670         


Phe Asp Ile Lys Val Glu Pro Ser Phe Leu Lys Asn Lys Asp Asp Tyr 
        675                 680                 685             


Ile Ala Phe Trp Ile Phe Cys Lys Met Leu Asp Ala Arg His Leu Ser 
    690                 695                 700                 


Glu Leu Arg Asn Glu Met Ile Lys Tyr Asp Gly His Leu Thr Gly Glu 
705                 710                 715                 720 


Gln Glu Ile Ile Gly Leu Ala Leu Leu Gly Val Asp Ser Arg Glu Asn 
                725                 730                 735     


Asp Trp Lys Gln Phe Phe Ser Ser Glu Arg Glu Tyr Glu Lys Ile Met 
            740                 745                 750         


Lys Gly Tyr Val Val Glu Glu Leu Tyr Gln Arg Glu Pro Tyr Arg Gln 
        755                 760                 765             


Ser Asp Gly Lys Thr Pro Ile Leu Phe Arg Gly Val Glu Gln Ala Arg 
    770                 775                 780                 


Lys Tyr Gly Thr Glu Thr Val Ile Gln Arg Leu Phe Asp Ala Asn Pro 
785                 790                 795                 800 


Glu Phe Lys Val Ser Lys Cys Asn Leu Ala Glu Trp Glu Arg Gln Lys 
                805                 810                 815     


Glu Thr Ile Glu Glu Thr Ile Lys Arg Arg Lys Glu Leu His Asn Glu 
            820                 825                 830         


Trp Ala Lys Asn Pro Lys Lys Pro Gln Asn Asn Ala Phe Phe Lys Glu 
        835                 840                 845             


Tyr Lys Glu Cys Cys Asp Ala Ile Asp Ala Tyr Asn Trp His Lys Asn 
    850                 855                 860                 


Lys Thr Thr Leu Ala Tyr Val Asn Glu Leu His His Leu Leu Ile Glu 
865                 870                 875                 880 


Ile Leu Gly Arg Tyr Val Gly Tyr Val Ala Ile Ala Asp Arg Asp Phe 
                885                 890                 895     


Gln Cys Met Ala Asn Gln Tyr Phe Lys His Ser Gly Ile Thr Glu Arg 
            900                 905                 910         


Val Glu Tyr Trp Gly Asp Asn Arg Leu Lys Ser Ile Lys Lys Leu Asp 
        915                 920                 925             


Thr Phe Leu Lys Lys Glu Gly Leu Phe Val Ser Glu Lys Asn Ala Arg 
    930                 935                 940                 


Asn His Ile Ala His Leu Asn Tyr Leu Ser Leu Lys Ser Glu Cys Thr 
945                 950                 955                 960 


Leu Leu Tyr Leu Ser Glu Arg Leu Arg Glu Ile Phe Lys Tyr Asp Arg 
                965                 970                 975     


Lys Leu Lys Asn Ala Val Ser Lys Ser Leu Ile Asp Ile Leu Asp Arg 
            980                 985                 990         


His Gly Met Ser Val Val Phe Ala  Asn Leu Lys Glu Asn  Lys His Arg 
        995                 1000                 1005             


Leu Val  Ile Lys Ser Leu Glu  Pro Lys Lys Leu Arg  His Leu Gly 
    1010                 1015                 1020             


Gly Lys  Lys Ile Asp Gly Gly  Tyr Ile Glu Thr Asn  Gln Val Ser 
    1025                 1030                 1035             


Glu Glu  Tyr Cys Gly Ile Val  Lys Arg Leu Leu Glu  Met 
    1040                 1045                 1050     


<210>  334
<211>  1182
<212>  PRT
<213>  Leptotrichia wadei

<400>  334

Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys 
1               5                   10                  15      


Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Lys Asp Leu Asp Glu Arg 
            20                  25                  30          


Lys Gln Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys Gln Ile Glu Ser 
        35                  40                  45              


Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys Arg Ile Glu 
    50                  55                  60                  


Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe Ile Lys Glu 
65                  70                  75                  80  


Leu Tyr Leu Asn Glu Lys Asn Glu Glu Trp Glu Leu Lys Asn Ile Asn 
                85                  90                  95      


Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly Tyr Lys Phe 
            100                 105                 110         


Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Tyr Lys Glu Tyr Tyr Leu 
        115                 120                 125             


Arg Ile Leu Phe Asn Asn Leu Ile Glu Lys Val Gln Asn Glu Asn Arg 
    130                 135                 140                 


Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Lys Tyr Lys Asn Arg Lys Ile Asp Leu Leu Leu Lys Ser Ile Asn 
                165                 170                 175     


Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu Glu 
            180                 185                 190         


Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe Tyr Glu 
        195                 200                 205             


Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile Leu 
    210                 215                 220                 


Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn Ile 
225                 230                 235                 240 


Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly Lys 
                245                 250                 255     


Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu Glu Asn Asn 
            260                 265                 270         


Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys Asn 
    290                 295                 300                 


Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met Phe 
305                 310                 315                 320 


Ile Glu Glu Val Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Phe Lys 
                325                 330                 335     


Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile Leu 
            340                 345                 350         


Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile Lys 
        355                 360                 365             


Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys 
    370                 375                 380                 


Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn 
385                 390                 395                 400 


Ser Tyr Tyr Asn Leu Phe Gly Arg Val Ser Gly Asp Ile Leu Gly Thr 
                405                 410                 415     


Glu Val Val Lys Ser Ser Lys Thr Asn Val Ile Lys Val Gly Ser His 
            420                 425                 430         


Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Phe Glu Ile Phe 
        435                 440                 445             


Asp Ala Asn Lys Ile Val Glu Ile Leu Glu Ser Ile Ser Tyr Ser Ile 
    450                 455                 460                 


Tyr Asn Val Arg Asn Gly Val Gly His Phe Asn Lys Leu Ile Leu Gly 
465                 470                 475                 480 


Lys Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Ile Glu Glu Asp 
                485                 490                 495     


Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg Gly 
            500                 505                 510         


Glu Ile Glu Arg Lys Val Lys Glu Lys Phe Leu Ser Asn Asn Leu Gln 
        515                 520                 525             


Tyr Tyr Tyr Ser Lys Glu Lys Ile Glu Asn Tyr Phe Glu Val Tyr Glu 
    530                 535                 540                 


Phe Glu Ile Leu Lys Arg Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg 
545                 550                 555                 560 


Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Asn Asn Lys Lys 
                565                 570                 575     


Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys 
            580                 585                 590         


Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn 
        595                 600                 605             


Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Glu Lys Ile 
    610                 615                 620                 


Val Leu Glu Val Lys Glu Glu Lys Lys Ser Arg Gly Asn Ile Asn Asn 
625                 630                 635                 640 


Lys Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys 
                645                 650                 655     


Ile Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu 
            660                 665                 670         


Arg Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr 
        675                 680                 685             


Ile Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr 
    690                 695                 700                 


Leu Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile 
705                 710                 715                 720 


Leu Cys Asn Asn Asn Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn 
                725                 730                 735     


Glu Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu 
            740                 745                 750         


Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu 
        755                 760                 765             


Phe Arg Asn Glu Leu Val Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu 
    770                 775                 780                 


Asp Glu Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr 
785                 790                 795                 800 


Leu Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys 
                805                 810                 815     


Ser Glu Glu Ile Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp 
            820                 825                 830         


Ser Asn Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp 
        835                 840                 845             


Glu Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn 
    850                 855                 860                 


Lys Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly 
865                 870                 875                 880 


Thr Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys 
                885                 890                 895     


Val Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu 
            900                 905                 910         


Gln Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu 
        915                 920                 925             


Leu His Lys Lys Trp Glu Gln Asn Lys Ile Thr Glu Lys Glu Ile Glu 
    930                 935                 940                 


Lys Tyr Asn Asn Thr Thr Arg Lys Ile Asn Glu Tyr Asn Tyr Leu Lys 
945                 950                 955                 960 


Asn Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser 
                965                 970                 975     


Asp Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp 
            980                 985                 990         


Phe Lys Phe Ile Val Ile Ala Ile  Lys Gln Phe Leu Arg  Glu Asn Asp 
        995                 1000                 1005             


Lys Glu  Lys Val Asn Glu Phe  Leu Asn Pro Pro Asp  Asn Ser Lys 
    1010                 1015                 1020             


Gly Lys  Lys Val Tyr Phe Ser  Val Ser Lys Tyr Lys  Asn Thr Val 
    1025                 1030                 1035             


Glu Asn  Ile Asp Gly Ile His  Lys Asn Phe Met Asn  Leu Ile Phe 
    1040                 1045                 1050             


Leu Asn  Asn Lys Phe Met Asn  Arg Lys Ile Asp Lys  Met Asn Cys 
    1055                 1060                 1065             


Ala Ile  Trp Val Tyr Phe Arg  Asn Tyr Ile Ala His  Phe Leu His 
    1070                 1075                 1080             


Leu His  Thr Lys Asn Glu Lys  Ile Ser Leu Ile Ser  Gln Met Asn 
    1085                 1090                 1095             


Leu Leu  Ile Lys Leu Phe Ser  Tyr Asp Lys Lys Val  Gln Asn His 
    1100                 1105                 1110             


Ile Leu  Lys Ser Thr Lys Thr  Leu Leu Glu Lys Tyr  Asn Ile Gln 
    1115                 1120                 1125             


Ile Asn  Phe Glu Ile Ser Asn  Asp Lys Asn Glu Val  Phe Lys Tyr 
    1130                 1135                 1140             


Lys Ile  Lys Asn Arg Leu Tyr  Ser Lys Lys Gly Lys  Met Leu Gly 
    1145                 1150                 1155             


Lys Asn  Asn Lys Phe Glu Ile  Leu Glu Asn Glu Phe  Leu Glu Asn 
    1160                 1165                 1170             


Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1175                 1180         


<210>  335
<211>  1285
<212>  PRT
<213>  Rhodobacter capsulatus

<400>  335

Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
1               5                   10                  15      


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
            20                  25                  30          


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
        35                  40                  45              


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
    50                  55                  60                  


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
65                  70                  75                  80  


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
                85                  90                  95      


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
            100                 105                 110         


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
        115                 120                 125             


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
    130                 135                 140                 


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
                165                 170                 175     


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
            180                 185                 190         


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
        195                 200                 205             


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
    210                 215                 220                 


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
225                 230                 235                 240 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
                245                 250                 255     


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
            260                 265                 270         


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
        275                 280                 285             


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
    290                 295                 300                 


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
305                 310                 315                 320 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
                325                 330                 335     


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
            340                 345                 350         


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
        355                 360                 365             


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
    370                 375                 380                 


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
385                 390                 395                 400 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
                405                 410                 415     


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
            420                 425                 430         


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
        435                 440                 445             


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
    450                 455                 460                 


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
465                 470                 475                 480 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
                485                 490                 495     


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
            500                 505                 510         


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
        515                 520                 525             


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
    530                 535                 540                 


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
545                 550                 555                 560 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
                565                 570                 575     


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
            580                 585                 590         


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
        595                 600                 605             


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
    610                 615                 620                 


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
625                 630                 635                 640 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
                645                 650                 655     


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
            660                 665                 670         


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
        675                 680                 685             


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
    690                 695                 700                 


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
705                 710                 715                 720 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
                725                 730                 735     


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
            740                 745                 750         


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
        755                 760                 765             


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
    770                 775                 780                 


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
785                 790                 795                 800 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
                805                 810                 815     


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
            820                 825                 830         


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
        835                 840                 845             


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
    850                 855                 860                 


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
865                 870                 875                 880 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
                885                 890                 895     


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
            900                 905                 910         


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
        915                 920                 925             


Ala Glu Ile Glu Asp Glu Thr Gln Glu Lys Ser Gln Ile Val Ala Ala 
    930                 935                 940                 


Gln Glu Leu Arg Thr Asp Leu His Asp Lys Val Met Lys Cys His Pro 
945                 950                 955                 960 


Lys Thr Ile Ser Pro Glu Glu Arg Gln Ser Tyr Ala Ala Ala Ile Lys 
                965                 970                 975     


Thr Ile Glu Glu His Arg Phe Leu Val Gly Arg Val Tyr Leu Gly Asp 
            980                 985                 990         


His Leu Arg Leu His Arg Leu Met  Met Asp Val Ile Gly  Arg Leu Ile 
        995                 1000                 1005             


Asp Tyr  Ala Gly Ala Tyr Glu  Arg Asp Thr Gly Thr  Phe Leu Ile 
    1010                 1015                 1020             


Asn Ala  Ser Lys Gln Leu Gly  Ala Gly Ala Asp Trp  Ala Val Thr 
    1025                 1030                 1035             


Ile Ala  Gly Ala Ala Asn Thr  Asp Ala Arg Thr Gln  Thr Arg Lys 
    1040                 1045                 1050             


Asp Leu  Ala His Phe Asn Val  Leu Asp Arg Ala Asp  Gly Thr Pro 
    1055                 1060                 1065             


Asp Leu  Thr Ala Leu Val Asn  Arg Ala Arg Glu Met  Met Ala Tyr 
    1070                 1075                 1080             


Asp Arg  Lys Arg Lys Asn Ala  Val Pro Arg Ser Ile  Leu Asp Met 
    1085                 1090                 1095             


Leu Ala  Arg Leu Gly Leu Thr  Leu Lys Trp Gln Met  Lys Asp His 
    1100                 1105                 1110             


Leu Leu  Gln Asp Ala Thr Ile  Thr Gln Ala Ala Ile  Lys His Leu 
    1115                 1120                 1125             


Asp Lys  Val Arg Leu Thr Val  Gly Gly Pro Ala Ala  Val Thr Glu 
    1130                 1135                 1140             


Ala Arg  Phe Ser Gln Asp Tyr  Leu Gln Met Val Ala  Ala Val Phe 
    1145                 1150                 1155             


Asn Gly  Ser Val Gln Asn Pro  Lys Pro Arg Arg Arg  Asp Asp Gly 
    1160                 1165                 1170             


Asp Ala  Trp His Lys Pro Pro  Lys Pro Ala Thr Ala  Gln Ser Gln 
    1175                 1180                 1185             


Pro Asp  Gln Lys Pro Pro Asn  Lys Ala Pro Ser Ala  Gly Ser Arg 
    1190                 1195                 1200             


Leu Pro  Pro Pro Gln Val Gly  Glu Val Tyr Glu Gly  Val Val Val 
    1205                 1210                 1215             


Lys Val  Ile Asp Thr Gly Ser  Leu Gly Phe Leu Ala  Val Glu Gly 
    1220                 1225                 1230             


Val Ala  Gly Asn Ile Gly Leu  His Ile Ser Arg Leu  Arg Arg Ile 
    1235                 1240                 1245             


Arg Glu  Asp Ala Ile Ile Val  Gly Arg Arg Tyr Arg  Phe Arg Val 
    1250                 1255                 1260             


Glu Ile  Tyr Val Pro Pro Lys  Ser Asn Thr Ser Lys  Leu Asn Ala 
    1265                 1270                 1275             


Ala Asp  Leu Val Arg Ile Asp  
    1280                 1285 


<210>  336
<211>  1159
<212>  PRT
<213>  Leptotrichia buccalis

<400>  336

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val 
            820                 825                 830         


Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr 
        915                 920                 925             


Lys Gln Ala Ile Glu Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Glu Asn Lys Lys Asn  Val Lys Tyr Lys Gly  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp 
    1010                 1015                 1020             


Glu Val  Lys Ile Asn Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ile Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  337
<211>  1389
<212>  PRT
<213>  Leptotrichia shahii

<400>  337

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Lys Asp Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Leu 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Lys Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Ile Leu Asn Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Arg Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ile Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro 
        675                 680                 685             


Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Asp Asp Leu Glu Glu Asn Glu Ser Lys Asn Ile Phe Leu Gln Glu Leu 
                725                 730                 735     


Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly Tyr 
    770                 775                 780                 


Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp Lys Thr Ile Val Ile 
            820                 825                 830         


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
        835                 840                 845             


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
                885                 890                 895     


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
            900                 905                 910         


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn 
        915                 920                 925             


Tyr Tyr Glu Asp Ile Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp 
    930                 935                 940                 


Ile Asn Gly Cys Asp Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile 
945                 950                 955                 960 


Phe Asp Asp Glu Thr Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu 
                965                 970                 975     


Gln Asp Glu Gln Arg Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys 
            980                 985                 990         


Lys Lys Val Asp Gln Tyr Ile Lys  Asp Lys Asp Gln Glu  Ile Lys Ser 
        995                 1000                 1005             


Lys Ile  Leu Cys Arg Ile Ile  Phe Asn Ser Asp Phe  Leu Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Glu Asp Met  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Asn Lys Phe Gln Glu  Ile Tyr Tyr Pro Lys  Glu Arg Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Asn Asp Ile 
    1070                 1075                 1080             


Lys Met  Ala Asp Ala Lys Phe  Leu Phe Asn Ile Asp  Gly Lys Asn 
    1085                 1090                 1095             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1100                 1105                 1110             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys 
    1115                 1120                 1125             


Tyr Ile  Lys Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1130                 1135                 1140             


Ile Gln  Asn Lys Asn Tyr Lys  Ser Phe Glu Lys Asp  Tyr Asn Arg 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Glu  Leu Lys Lys 
    1325                 1330                 1335             


Lys Phe  Lys Leu Ile Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met 
    1340                 1345                 1350             


Lys Pro  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu 
    1370                 1375                 1380             


Asn Thr  Asn Asp Thr Leu 
    1385                 


<210>  338
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  338

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


