                         SEQUENCE LISTING

<110>  PROTHENA BIOSCIENCES, INC.
       SALMANS, JOSHUA  R.
       ALEXANDER, SVETLANA
       BARBOUR, ROBIN
       HIGAKI, JEFFREY  N.
       NIJJAR, TARLOCHAN
 
<120>  ANTI-TRANSTHYRETIN ANTIBODIES

<130>  057450-516711

<150>  US 62/569,436
<151>  2017-10-06

<150>  US 62/598,965
<151>  2017-12-14

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  139
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  1

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Asn Leu Ser Cys Val Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Phe Trp Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gly Gln Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Phe Leu Gln Met Ser Lys Val Arg Ser Glu Asp Ser Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210>  2
<211>  417
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  2
atggattttg ggctgatttt tttcattgtt gcccttttaa aaggggtcca gtgtgaggta       60

aagcttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa tctctcctgt      120

gtagcctcag gattcgattt tagtagattc tggatgagtt gggctcggca ggctccaggg      180

agaggacagg aatggattgg agagattaat ccaggaagca gtacgataaa ctatacgcca      240

tctctgaagg ataaattcat catctccaga gacaacgcca aaaatacgct gttcctgcaa      300

atgagcaaag tgagatctga ggactcagcc ctttattact gtgcaagact ggggtatggt      360

aactacggat gggctctgga ctactggggt caaggaacct cagtcaccgt ctcctca         417


<210>  3
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  3

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Arg Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val Asp Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys 
    130     


<210>  4
<211>  393
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  4
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagaagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag cattgtagat agtaatggaa acacctattt agaatggtac      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggaatttat tactgctttc aaggttcaca tgttccgctc      360

acgttcggtg ctgggaccaa gttggagctg aaa                                   393


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  5

Gly Phe Asp Phe Ser Arg Phe Trp Met Ser 
1               5                   10  


<210>  6
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  6
ggattcgatt ttagtagatt ctggatgagt                                        30


<210>  7
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  7

Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys 
1               5                   10                  15      


Asp 
    


<210>  8
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  8
gagattaatc caggaagcag tacgataaac tatacgccat ctctgaagga t                51


<210>  9
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  9

Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr 
1               5                   10          


<210>  10
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  10
ctggggtatg gtaactacgg atgggctctg gactac                                 36


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  11

Arg Ser Ser Gln Ser Ile Val Asp Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  12
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  12
agatctagtc agagcattgt agatagtaat ggaaacacct atttagaa                    48


<210>  13
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  13

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  14
aaagtttcca accgattttc t                                                 21


<210>  15
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  15

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  16
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  16
tttcaaggtt cacatgttcc gctcacg                                           27


<210>  17
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  17

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  18
<211>  993
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  18
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacacgc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa tga                                   993


<210>  19
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  19

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  20
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  20
cggggaactg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa       60

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      120

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      180

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      240

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      300

aagagcttca acaggggaga gtgttag                                          327


<210>  21
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  21

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  22
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  23
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  23

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  24
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  24

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  25
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  25

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  26
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  27
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Gln Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  28
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu Met Val Lys Val 
1               5                   10                  15      


Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val Ala Val His Val 
            20                  25                  30          


Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys 
        35                  40                  45              


Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu Glu Gln Phe 
    50                  55                  60                  


Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys Ser Tyr Trp Lys 
65                  70                  75                  80  


Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu Val Val Phe Thr 
                85                  90                  95      


Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser 
            100                 105                 110         


Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
        115                 120                 125         


<210>  29
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Ser Tyr Ser 
        115                 120                 125             


Thr Thr Ala Val Val Thr Asn Pro Lys Glu 
    130                 135             


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Pro Arg Arg Tyr Thr Ile Ala Ala 
1               5                   


<210>  31
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  31

Phe His Glu His Ala Glu Val Val Phe Thr Ala Asn Asp Ser Gly Pro 
1               5                   10                  15      


Arg Arg Tyr Thr Ile Ala Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr 
            20                  25                  30          


Thr Ala Val Val Thr Asn Pro Lys Glu 
        35                  40      


<210>  32
<211>  990
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  32
gcctccacca agggtccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggtaaa                                       990


<210>  33
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  33
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  34
<211>  318
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  34
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  35
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  35

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  36
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  36
atgaactttg ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgt          57


<210>  37
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  37

Met Glu Ser His Thr Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly 
            20  


<210>  38
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  38
atggagtcac atactcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60


<210>  39
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  39

Ser Tyr Thr Met Ser 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  40

Glu Ile Asn Asn Ser Gly Asp Thr Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  41

His Tyr Tyr Tyr Gly Gly Gly Tyr Gly Gly Trp Phe Phe Asp Val 
1               5                   10                  15  


<210>  42
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  42

Arg Ser Asn Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  43
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  43

Arg Val Ser Asn Leu Ala Ser 
1               5           


<210>  44
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  44

Met Gln His Leu Glu Tyr Pro Leu Thr 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  45

Glu His Ala Glu Val Val Phe Thr Ala 
1               5                   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  46

Asn Tyr Ala Met Ser 
1               5   


<210>  47
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  47

Ser Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  48
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  48

Tyr Tyr Tyr Gly Gln Tyr Phe Asp Phe 
1               5                   


<210>  49
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  49

Lys Ala Ser Gln Asp Val Ser Thr Thr Val Ala 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  50

Ser Ala Ser Tyr Arg Cys Thr 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  51

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  52

Asn Tyr Tyr Met Ser 
1               5   


<210>  53
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  53

Tyr Ile Ser Ile Asp Gly Asn Asn Ile Tyr His Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  54

Asp Ser Asp Tyr Gly Tyr Phe Asp Val 
1               5                   


<210>  55
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  55

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  56
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  56

Lys Val Ser Lys Arg Phe Ser 
1               5           


<210>  57
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  57

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  58
<211>  455
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ser Gly Thr Tyr Thr Tyr Tyr Thr Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Lys Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Ala Tyr Gly Arg Glu Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu 
                165                 170                 175     


Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr 
    210                 215                 220                 


Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro 
225                 230                 235                 240 


Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys 
                245                 250                 255     


Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Glu Asp Asp Pro Asp Val Arg Ile Ser Trp Phe Val Asn 
        275                 280                 285             


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
    290                 295                 300                 


Asn Ser Thr Ile Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
305                 310                 315                 320 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg 
            340                 345                 350         


Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg 
        355                 360                 365             


Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp 
    370                 375                 380                 


Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys 
385                 390                 395                 400 


Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser 
                405                 410                 415     


Lys Leu Asp Ile Lys Thr Ser Thr Val Gly Glu Asn Arg Phe Leu Leu 
            420                 425                 430         


Met Gln Arg Glu Thr Arg Gly Ser Glu Lys Leu Leu Pro Glu Glu Asp 
        435                 440                 445             


His Leu Pro Ser Pro Gly Lys 
    450                 455 


<210>  59
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  59

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asp Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Asn Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Lys Gln 
                85                  90                  95      


Ser Asn Tyr Leu Arg Thr Phe Gly Gly Gly Thr Arg Val Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  60
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  60

Arg Tyr Trp Ile Thr 
1               5   


<210>  61
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  61

Asp Ile Tyr Pro Gly Ser Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  62
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  62

Tyr Tyr Gly Ser Thr Tyr Phe Tyr Val 
1               5                   


<210>  63
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  63

Arg Ser Ser Lys Ser Leu Leu Tyr Lys Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  64

Leu Met Ser Thr Arg Ala Ser 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  65

Gln Gln Leu Val Glu Tyr Pro Arg Thr 
1               5                   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  66

Ser Tyr Ala Met Ser 
1               5   


<210>  67
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  67

Ser Ile Ser Gly Ser Gly Asp Thr Thr Lys Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  68

Asp Gly Ser Gly Arg Ile Asp Pro Phe Ala Leu 
1               5                   10      


<210>  69
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  69

Arg Ser Ser Arg Ser Leu Val Tyr Ser Asp Gly Asn Ile Tyr Leu Asn 
1               5                   10                  15      


<210>  70
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  70

Lys Val Ser Asn Arg Asp Ser Gly 
1               5               


<210>  71
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  71

Met Gln Gly Thr His Trp Pro Arg Thr 
1               5                   


<210>  72
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  72

Ala Asp Asp Thr Trp Glu Pro Phe Ala Ser Gly Lys Thr 
1               5                   10              


<210>  73
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  73

Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr Glu 
1               5                   10              


<210>  74
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  74

Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val 
1               5                   10              


<210>  75
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  75

Ser Tyr Thr Met Ser 
1               5   


<210>  76
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  76

Glu Ile Ser Asn Ser Gly Asp Thr Thr Tyr Tyr Pro Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  77

His Tyr Tyr Tyr Gly Gly Gly Tyr Gly Gly Trp Phe Phe Asp Val 
1               5                   10                  15  


<210>  78
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  78

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  79
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  79

Arg Val Ser Asn Leu Ala Ser 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  80

Met Gln His Leu Glu Tyr Pro Leu Thr 
1               5                   


<210>  81
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  81

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Val Ala Ser Gly Phe Asp Phe Ser Arg Phe 
            20                  25                  30          


Trp Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gly Gln Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  82
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  82

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Leu Ala Tyr Ser Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Asp Asn Ile Leu Asp Tyr Val Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  83
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Asn Ser Asn Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            100                 105                 110         


<210>  84
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  85
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Phe 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  86
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  86

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Phe 
            20                  25                  30          


Trp Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Gln Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn Tyr Thr Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  87
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  87

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Asp Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  88
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  88

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  89
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  89

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  90
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  91
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  91

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Asp Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  92
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  92

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Asp Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  93
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  93

Arg Phe Trp Met Ser 
1               5   


<210>  94
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  94

Gly Phe Asp Phe Ser Arg Phe 
1               5           


<210>  95
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  95

Ser Arg Phe Trp Met Ser 
1               5       


<210>  96
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  96

Asn Pro Gly Ser Ser Thr 
1               5       


<210>  97
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  97

Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn 
1               5                   10  


<210>  98
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  98

Trp Ile Gly Glu Ile Asn Pro Gly Ser Ser Thr Ile Asn 
1               5                   10              


<210>  99
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  99

Ala Arg Leu Gly Tyr Gly Asn Tyr Gly Trp Ala Leu Asp 
1               5                   10              


<210>  100
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  100

Asn Thr Tyr Leu Glu Trp Tyr 
1               5           


<210>  101
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  101

Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
1               5                   10  


<210>  102
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  102

Phe Gln Gly Ser His Val Pro Leu 
1               5               


