                               SEQUENCE LISTING

<110> THE CHARLES STARK DRAPER LABORATORY, INC.
 
<120> HYBRIDIZATION IMMUNOPRECIPITATION SEQUENCING (HIP-SEQ)

<130> 0352.0043WO1

<140>
<141>

<150> 62/572,240
<151> 2017-10-13

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 149
<212> PRT
<213> Enterobacteria phage T7

<400> 1
Met Ala Gly Tyr Gly Ala Lys Gly Ile Arg Lys Val Gly Ala Phe Arg 
1               5                   10                  15      


Ser Gly Leu Glu Asp Lys Val Ser Lys Gln Leu Glu Ser Lys Gly Ile 
            20                  25                  30          


Lys Phe Glu Tyr Glu Glu Trp Lys Val Pro Tyr Val Ile Pro Ala Ser 
        35                  40                  45              


Asn His Thr Tyr Thr Pro Asp Phe Leu Leu Pro Asn Gly Ile Phe Val 
    50                  55                  60                  


Glu Thr Lys Gly Leu Trp Glu Ser Asp Asp Arg Lys Lys His Leu Leu 
65                  70                  75                  80  


Ile Arg Glu Gln His Pro Glu Leu Asp Ile Arg Ile Val Phe Ser Ser 
                85                  90                  95      


Ser Arg Thr Lys Leu Tyr Lys Gly Ser Pro Thr Ser Tyr Gly Glu Phe 
            100                 105                 110         


Cys Glu Lys His Gly Ile Lys Phe Ala Asp Lys Leu Ile Pro Ala Glu 
        115                 120                 125             


Trp Ile Lys Glu Pro Lys Lys Glu Val Pro Phe Asp Arg Leu Lys Arg 
    130                 135                 140                 


Lys Gly Gly Lys Lys 
145                 


<210> 2
<211> 157
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Bacteria recombination endonuclease VII sequence"

<400> 2
Met Leu Leu Thr Gly Lys Leu Tyr Lys Glu Glu Lys Gln Lys Phe Tyr 
1               5                   10                  15      


Asp Ala Gln Asn Gly Lys Cys Leu Ile Cys Gln Arg Glu Leu Asn Pro 
            20                  25                  30          


Asp Val Gln Ala Asn His Leu Asp His Asp His Glu Leu Asn Gly Pro 
        35                  40                  45              


Lys Ala Gly Lys Val Arg Gly Leu Leu Cys Asn Leu Cys Asn Ala Ala 
    50                  55                  60                  


Glu Gly Gln Met Lys His Lys Phe Asn Arg Ser Gly Leu Lys Gly Gln 
65                  70                  75                  80  


Gly Val Asp Tyr Leu Glu Trp Leu Glu Asn Leu Leu Thr Tyr Leu Lys 
                85                  90                  95      


Ser Asp Tyr Thr Gln Asn Asn Ile His Pro Asn Phe Val Gly Asp Lys 
            100                 105                 110         


Ser Lys Glu Phe Ser Arg Leu Gly Lys Glu Glu Met Met Ala Glu Met 
        115                 120                 125             


Leu Gln Arg Gly Phe Glu Tyr Asn Glu Ser Asp Thr Lys Thr Gln Leu 
    130                 135                 140                 


Ile Ala Ser Phe Lys Lys Gln Leu Arg Lys Ser Leu Lys 
145                 150                 155         


<210> 3
<211> 296
<212> PRT
<213> Apium graveolens

<400> 3
Met Thr Arg Leu Tyr Ser Val Phe Phe Leu Leu Leu Ala Leu Val Val 
1               5                   10                  15      


Glu Pro Gly Val Arg Ala Trp Ser Lys Glu Gly His Val Met Thr Cys 
            20                  25                  30          


Gln Ile Ala Gln Asp Leu Leu Glu Pro Glu Ala Ala His Ala Val Lys 
        35                  40                  45              


Met Leu Leu Pro Asp Tyr Ala Asn Gly Asn Leu Ser Ser Leu Cys Val 
    50                  55                  60                  


Trp Pro Asp Gln Ile Arg His Trp Tyr Lys Tyr Arg Trp Thr Ser Ser 
65                  70                  75                  80  


Leu His Phe Ile Asp Thr Pro Asp Gln Ala Cys Ser Phe Asp Tyr Gln 
                85                  90                  95      


Arg Asp Cys His Asp Pro His Gly Gly Lys Asp Met Cys Val Ala Gly 
            100                 105                 110         


Ala Ile Gln Asn Phe Thr Ser Gln Leu Gly His Phe Arg His Gly Thr 
        115                 120                 125             


Ser Asp Arg Arg Tyr Asn Met Thr Glu Ala Leu Leu Phe Leu Ser His 
    130                 135                 140                 


Phe Met Gly Asp Ile His Gln Pro Met His Val Gly Phe Thr Ser Asp 
145                 150                 155                 160 


Met Gly Gly Asn Ser Ile Asp Leu Arg Trp Phe Arg His Lys Ser Asn 
                165                 170                 175     


Leu His His Val Trp Asp Arg Glu Ile Ile Leu Thr Ala Ala Ala Asp 
            180                 185                 190         


Tyr His Gly Lys Asp Met His Ser Leu Leu Gln Asp Ile Gln Arg Asn 
        195                 200                 205             


Phe Thr Glu Gly Ser Trp Leu Gln Asp Val Glu Ser Trp Lys Glu Cys 
    210                 215                 220                 


Asp Asp Ile Ser Thr Cys Ala Asn Lys Tyr Ala Lys Glu Ser Ile Lys 
225                 230                 235                 240 


Leu Ala Cys Asn Trp Gly Tyr Lys Asp Val Glu Ser Gly Glu Thr Leu 
                245                 250                 255     


Ser Asp Lys Tyr Phe Asn Thr Arg Met Pro Ile Val Met Lys Arg Ile 
            260                 265                 270         


Ala Gln Gly Gly Ile Arg Leu Ser Met Ile Leu Asn Arg Val Leu Gly 
        275                 280                 285             


Ser Ser Ala Asp His Ser Leu Ala 
    290                 295     


<210> 4
<211> 310
<212> PRT
<213> Apium graveolens

<400> 4
Met Gly Met Leu Thr Tyr Thr Gly Ile Tyr Phe Leu Leu Leu Leu Pro 
1               5                   10                  15      


Ser Val Phe Cys Trp Gly Lys Gln Gly His Phe Ala Ile Cys Lys Ile 
            20                  25                  30          


Ala Gln Gly Phe Leu Ser Lys Asp Ala Leu Thr Ala Val Lys Ala Leu 
        35                  40                  45              


Leu Pro Glu Tyr Ala Asp Gly Asp Leu Ala Ala Val Cys Ser Trp Ala 
    50                  55                  60                  


Asp Glu Val Arg Phe His Met Arg Trp Ser Ser Pro Leu His Tyr Val 
65                  70                  75                  80  


Asp Thr Pro Asp Phe Arg Cys Asn Tyr Lys Tyr Cys Arg Asp Cys His 
                85                  90                  95      


Asp Ser Val Gly Arg Lys Asp Arg Cys Val Thr Gly Ala Ile His Asn 
            100                 105                 110         


Tyr Thr Glu Gln Leu Leu Leu Gly Val His Asp Leu Asn Ser Lys Met 
        115                 120                 125             


Asn Asn Asn Leu Thr Glu Ala Leu Met Phe Leu Ser His Phe Val Gly 
    130                 135                 140                 


Asp Val His Gln Pro Leu His Val Gly Phe Leu Gly Asp Glu Gly Gly 
145                 150                 155                 160 


Asn Thr Ile Thr Val Arg Trp Tyr Arg Arg Lys Thr Asn Leu His His 
                165                 170                 175     


Val Trp Asp Thr Met Met Ile Glu Ser Ser Leu Lys Thr Phe Tyr Asn 
            180                 185                 190         


Ser Asp Leu Ser Ser Leu Ile Gln Ala Ile Gln Ser Asn Ile Thr Gly 
        195                 200                 205             


Val Trp Leu Thr Asp Ser Leu Ser Trp Ser Asn Cys Thr Ala Asp His 
    210                 215                 220                 


Val Val Cys Pro Asp Pro Tyr Ala Ser Glu Ser Ile Glu Leu Ala Cys 
225                 230                 235                 240 


Lys Phe Ala Tyr Arg Asn Ala Thr Pro Gly Thr Thr Leu Gly Asp Glu 
                245                 250                 255     


Tyr Phe Leu Ser Arg Leu Pro Val Ala Glu Lys Arg Leu Ala Gln Ala 
            260                 265                 270         


Gly Val Arg Leu Ala Ala Thr Leu Asn Arg Ile Phe Thr Ser Asn Pro 
        275                 280                 285             


Ser Asp Leu Thr Arg Leu Asn Met His Asn Gly Gly His Arg Ser Ser 
    290                 295                 300                 


Asn Asn Ile Glu Ile Val 
305                 310 


<210> 5
<211> 853
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Proteobacteria DNA mismatch repair protein MutS sequence"

<400> 5
Met Ser Ala Ile Glu Asn Phe Asp Ala His Thr Pro Met Met Gln Gln 
1               5                   10                  15      


Tyr Leu Arg Leu Lys Ala Gln His Pro Glu Ile Leu Leu Phe Tyr Arg 
            20                  25                  30          


Met Gly Asp Phe Tyr Glu Leu Phe Tyr Asp Asp Ala Lys Arg Ala Ser 
        35                  40                  45              


Gln Leu Leu Asp Ile Ser Leu Thr Lys Arg Gly Ala Ser Ala Gly Glu 
    50                  55                  60                  


Pro Ile Pro Met Ala Gly Ile Pro Tyr His Ala Val Glu Asn Tyr Leu 
65                  70                  75                  80  


Ala Lys Leu Val Asn Gln Gly Glu Ser Val Ala Ile Cys Glu Gln Ile 
                85                  90                  95      


Gly Asp Pro Ala Thr Ser Lys Gly Pro Val Glu Arg Lys Val Val Arg 
            100                 105                 110         


Ile Val Thr Pro Gly Thr Ile Ser Asp Glu Ala Leu Leu Gln Glu Arg 
        115                 120                 125             


Gln Asp Asn Leu Leu Ala Ala Ile Trp Gln Asp Ser Lys Gly Phe Gly 
    130                 135                 140                 


Tyr Ala Thr Leu Asp Ile Ser Ser Gly Arg Phe Arg Leu Ser Glu Pro 
145                 150                 155                 160 


Ala Asp Arg Glu Thr Met Ala Ala Glu Leu Gln Arg Thr Asn Pro Ala 
                165                 170                 175     


Glu Leu Leu Tyr Ala Glu Asp Phe Ala Glu Met Ser Leu Ile Glu Gly 
            180                 185                 190         


Arg Arg Gly Leu Arg Arg Arg Pro Leu Trp Glu Phe Glu Ile Asp Thr 
        195                 200                 205             


Ala Arg Gln Gln Leu Asn Leu Gln Phe Gly Thr Arg Asp Leu Val Gly 
    210                 215                 220                 


Phe Gly Val Glu Asn Ala Pro Arg Gly Leu Cys Ala Ala Gly Cys Leu 
225                 230                 235                 240 


Leu Gln Tyr Ala Lys Asp Thr Gln Arg Thr Thr Leu Pro His Ile Arg 
                245                 250                 255     


Ser Ile Thr Met Glu Arg Glu Gln Asp Ser Ile Ile Met Asp Ala Ala 
            260                 265                 270         


Thr Arg Arg Asn Leu Glu Ile Thr Gln Asn Leu Ala Gly Gly Ala Glu 
        275                 280                 285             


Asn Thr Leu Ala Ser Val Leu Asp Cys Thr Val Thr Pro Met Gly Ser 
    290                 295                 300                 


Arg Met Leu Lys Arg Trp Leu His Met Pro Val Arg Asp Thr Arg Val 
305                 310                 315                 320 


Leu Leu Glu Arg Gln Gln Thr Ile Gly Ala Leu Gln Asp Phe Thr Ala 
                325                 330                 335     


Gly Leu Gln Pro Val Leu Arg Gln Val Gly Asp Leu Glu Arg Ile Leu 
            340                 345                 350         


Ala Arg Leu Ala Leu Arg Thr Ala Arg Pro Arg Asp Leu Ala Arg Met 
        355                 360                 365             


Arg His Ala Phe Gln Gln Leu Pro Glu Leu Arg Ala Gln Leu Glu Thr 
    370                 375                 380                 


Val Asp Ser Ala Pro Val Gln Ala Leu Arg Glu Lys Met Gly Glu Phe 
385                 390                 395                 400 


Ala Glu Leu Arg Asp Leu Leu Glu Arg Ala Ile Ile Asp Thr Pro Pro 
                405                 410                 415     


Val Leu Val Arg Asp Gly Gly Val Ile Ala Ser Gly Tyr Asn Glu Glu 
            420                 425                 430         


Leu Asp Glu Trp Arg Ala Leu Ala Asp Gly Ala Thr Asp Tyr Leu Glu 
        435                 440                 445             


Arg Leu Glu Val Arg Glu Arg Glu Arg Thr Gly Leu Asp Thr Leu Lys 
    450                 455                 460                 


Val Gly Phe Asn Ala Val His Gly Tyr Tyr Ile Gln Ile Ser Arg Gly 
465                 470                 475                 480 


Gln Ser His Leu Ala Pro Ile Asn Tyr Met Arg Arg Gln Thr Leu Lys 
                485                 490                 495     


Asn Ala Glu Arg Tyr Ile Ile Pro Glu Leu Lys Glu Tyr Glu Asp Lys 
            500                 505                 510         


Val Leu Thr Ser Lys Gly Lys Ala Leu Ala Leu Glu Lys Gln Leu Tyr 
        515                 520                 525             


Glu Glu Leu Phe Asp Leu Leu Leu Pro His Leu Glu Ala Leu Gln Gln 
    530                 535                 540                 


Ser Ala Ser Ala Leu Ala Glu Leu Asp Val Leu Val Asn Leu Ala Glu 
545                 550                 555                 560 


Arg Ala Tyr Thr Leu Asn Tyr Thr Cys Pro Thr Phe Ile Asp Lys Pro 
                565                 570                 575     


Gly Ile Arg Ile Thr Glu Gly Arg His Pro Val Val Glu Gln Val Leu 
            580                 585                 590         


Asn Glu Pro Phe Ile Ala Asn Pro Leu Asn Leu Ser Pro Gln Arg Arg 
        595                 600                 605             


Met Leu Ile Ile Thr Gly Pro Asn Met Gly Gly Lys Ser Thr Tyr Met 
    610                 615                 620                 


Arg Gln Thr Ala Leu Ile Ala Leu Met Ala Tyr Ile Gly Ser Tyr Val 
625                 630                 635                 640 


Pro Ala Gln Lys Val Glu Ile Gly Pro Ile Asp Arg Ile Phe Thr Arg 
                645                 650                 655     


Val Gly Ala Ala Asp Asp Leu Ala Ser Gly Arg Ser Thr Phe Met Val 
            660                 665                 670         


Glu Met Thr Glu Thr Ala Asn Ile Leu His Asn Ala Thr Glu Tyr Ser 
        675                 680                 685             


Leu Val Leu Met Asp Glu Ile Gly Arg Gly Thr Ser Thr Tyr Asp Gly 
    690                 695                 700                 


Leu Ser Leu Ala Trp Ala Cys Ala Glu Asn Leu Ala Asn Lys Ile Lys 
705                 710                 715                 720 


Ala Leu Thr Leu Phe Ala Thr His Tyr Phe Glu Leu Thr Gln Leu Pro 
                725                 730                 735     


Glu Lys Met Glu Gly Val Ala Asn Val His Leu Asp Ala Leu Glu His 
            740                 745                 750         


Gly Asp Thr Ile Ala Phe Met His Ser Val Gln Asp Gly Ala Ala Ser 
        755                 760                 765             


Lys Ser Tyr Gly Leu Ala Val Ala Ala Leu Ala Gly Val Pro Lys Glu 
    770                 775                 780                 


Val Ile Lys Arg Ala Arg Gln Lys Leu Arg Glu Leu Glu Ser Ile Ser 
785                 790                 795                 800 


Pro Asn Ala Ala Ala Thr Gln Val Asp Gly Thr Gln Met Ser Leu Leu 
                805                 810                 815     


Ser Val Pro Glu Glu Thr Ser Pro Ala Val Glu Ala Leu Glu Asn Leu 
            820                 825                 830         


Asp Pro Asp Ser Leu Thr Pro Arg Gln Ala Leu Glu Trp Ile Tyr Arg 
        835                 840                 845             


Leu Lys Ser Leu Val 
    850             


<210> 6
<211> 964
<212> PRT
<213> Saccharomyces cerevisiae S288C

<400> 6
Met Ser Ser Thr Arg Pro Glu Leu Lys Phe Ser Asp Val Ser Glu Glu 
1               5                   10                  15      


Arg Asn Phe Tyr Lys Lys Tyr Thr Gly Leu Pro Lys Lys Pro Leu Lys 
            20                  25                  30          


Thr Ile Arg Leu Val Asp Lys Gly Asp Tyr Tyr Thr Val Ile Gly Ser 
        35                  40                  45              


Asp Ala Ile Phe Val Ala Asp Ser Val Tyr His Thr Gln Ser Val Leu 
    50                  55                  60                  


Lys Asn Cys Gln Leu Asp Pro Val Thr Ala Lys Asn Phe His Glu Pro 
65                  70                  75                  80  


Thr Lys Tyr Val Thr Val Ser Leu Gln Val Leu Ala Thr Leu Leu Lys 
                85                  90                  95      


Leu Cys Leu Leu Asp Leu Gly Tyr Lys Val Glu Ile Tyr Asp Lys Gly 
            100                 105                 110         


Trp Lys Leu Ile Lys Ser Ala Ser Pro Gly Asn Ile Glu Gln Val Asn 
        115                 120                 125             


Glu Leu Met Asn Met Asn Ile Asp Ser Ser Ile Ile Ile Ala Ser Leu 
    130                 135                 140                 


Lys Val Gln Trp Asn Ser Gln Asp Gly Asn Cys Ile Ile Gly Val Ala 
145                 150                 155                 160 


Phe Ile Asp Thr Thr Ala Tyr Lys Val Gly Met Leu Asp Ile Val Asp 
                165                 170                 175     


Asn Glu Val Tyr Ser Asn Leu Glu Ser Phe Leu Ile Gln Leu Gly Val 
            180                 185                 190         


Lys Glu Cys Leu Val Gln Asp Leu Thr Ser Asn Ser Asn Ser Asn Ala 
        195                 200                 205             


Glu Met Gln Lys Val Ile Asn Val Ile Asp Arg Cys Gly Cys Val Val 
    210                 215                 220                 


Thr Leu Leu Lys Asn Ser Glu Phe Ser Glu Lys Asp Val Glu Leu Asp 
225                 230                 235                 240 


Leu Thr Lys Leu Leu Gly Asp Asp Leu Ala Leu Ser Leu Pro Gln Lys 
                245                 250                 255     


Tyr Ser Lys Leu Ser Met Gly Ala Cys Asn Ala Leu Ile Gly Tyr Leu 
            260                 265                 270         


Gln Leu Leu Ser Glu Gln Asp Gln Val Gly Lys Tyr Glu Leu Val Glu 
        275                 280                 285             


His Lys Leu Lys Glu Phe Met Lys Leu Asp Ala Ser Ala Ile Lys Ala 
    290                 295                 300                 


Leu Asn Leu Phe Pro Gln Gly Pro Gln Asn Pro Phe Gly Ser Asn Asn 
305                 310                 315                 320 


Leu Ala Val Ser Gly Phe Thr Ser Ala Gly Asn Ser Gly Lys Val Thr 
                325                 330                 335     


Ser Leu Phe Gln Leu Leu Asn His Cys Lys Thr Asn Ala Gly Val Arg 
            340                 345                 350         


Leu Leu Asn Glu Trp Leu Lys Gln Pro Leu Thr Asn Ile Asp Glu Ile 
        355                 360                 365             


Asn Lys Arg His Asp Leu Val Asp Tyr Leu Ile Asp Gln Ile Glu Leu 
    370                 375                 380                 


Arg Gln Met Leu Thr Ser Glu Tyr Leu Pro Met Ile Pro Asp Ile Arg 
385                 390                 395                 400 


Arg Leu Thr Lys Lys Leu Asn Lys Arg Gly Asn Leu Glu Asp Val Leu 
                405                 410                 415     


Lys Ile Tyr Gln Phe Ser Lys Arg Ile Pro Glu Ile Val Gln Val Phe 
            420                 425                 430         


Thr Ser Phe Leu Glu Asp Asp Ser Pro Thr Glu Pro Val Asn Glu Leu 
        435                 440                 445             


Val Arg Ser Val Trp Leu Ala Pro Leu Ser His His Val Glu Pro Leu 
    450                 455                 460                 


Ser Lys Phe Glu Glu Met Val Glu Thr Thr Val Asp Leu Asp Ala Tyr 
465                 470                 475                 480 


Glu Glu Asn Asn Glu Phe Met Ile Lys Val Glu Phe Asn Glu Glu Leu 
                485                 490                 495     


Gly Lys Ile Arg Ser Lys Leu Asp Thr Leu Arg Asp Glu Ile His Ser 
            500                 505                 510         


Ile His Leu Asp Ser Ala Glu Asp Leu Gly Phe Asp Pro Asp Lys Lys 
        515                 520                 525             


Leu Lys Leu Glu Asn His His Leu His Gly Trp Cys Met Arg Leu Thr 
    530                 535                 540                 


Arg Asn Asp Ala Lys Glu Leu Arg Lys His Lys Lys Tyr Ile Glu Leu 
545                 550                 555                 560 


Ser Thr Val Lys Ala Gly Ile Phe Phe Ser Thr Lys Gln Leu Lys Ser 
                565                 570                 575     


Ile Ala Asn Glu Thr Asn Ile Leu Gln Lys Glu Tyr Asp Lys Gln Gln 
            580                 585                 590         


Ser Ala Leu Val Arg Glu Ile Ile Asn Ile Thr Leu Thr Tyr Thr Pro 
        595                 600                 605             


Val Phe Glu Lys Leu Ser Leu Val Leu Ala His Leu Asp Val Ile Ala 
    610                 615                 620                 


Ser Phe Ala His Thr Ser Ser Tyr Ala Pro Ile Pro Tyr Ile Arg Pro 
625                 630                 635                 640 


Lys Leu His Pro Met Asp Ser Glu Arg Arg Thr His Leu Ile Ser Ser 
                645                 650                 655     


Arg His Pro Val Leu Glu Met Gln Asp Asp Ile Ser Phe Ile Ser Asn 
            660                 665                 670         


Asp Val Thr Leu Glu Ser Gly Lys Gly Asp Phe Leu Ile Ile Thr Gly 
        675                 680                 685             


Pro Asn Met Gly Gly Lys Ser Thr Tyr Ile Arg Gln Val Gly Val Ile 
    690                 695                 700                 


Ser Leu Met Ala Gln Ile Gly Cys Phe Val Pro Cys Glu Glu Ala Glu 
705                 710                 715                 720 


Ile Ala Ile Val Asp Ala Ile Leu Cys Arg Val Gly Ala Gly Asp Ser 
                725                 730                 735     


Gln Leu Lys Gly Val Ser Thr Phe Met Val Glu Ile Leu Glu Thr Ala 
            740                 745                 750         


Ser Ile Leu Lys Asn Ala Ser Lys Asn Ser Leu Ile Ile Val Asp Glu 
        755                 760                 765             


Leu Gly Arg Gly Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala 
    770                 775                 780                 


Ile Ala Glu His Ile Ala Ser Lys Ile Gly Cys Phe Ala Leu Phe Ala 
785                 790                 795                 800 


Thr His Phe His Glu Leu Thr Glu Leu Ser Glu Lys Leu Pro Asn Val 
                805                 810                 815     


Lys Asn Met His Val Val Ala His Ile Glu Lys Asn Leu Lys Glu Gln 
            820                 825                 830         


Lys His Asp Asp Glu Asp Ile Thr Leu Leu Tyr Lys Val Glu Pro Gly 
        835                 840                 845             


Ile Ser Asp Gln Ser Phe Gly Ile His Val Ala Glu Val Val Gln Phe 
    850                 855                 860                 


Pro Glu Lys Ile Val Lys Met Ala Lys Arg Lys Ala Asn Glu Leu Asp 
865                 870                 875                 880 


Asp Leu Lys Thr Asn Asn Glu Asp Leu Lys Lys Ala Lys Leu Ser Leu 
                885                 890                 895     


Gln Glu Val Asn Glu Gly Asn Ile Arg Leu Lys Ala Leu Leu Lys Glu 
            900                 905                 910         


Trp Ile Arg Lys Val Lys Glu Glu Gly Leu His Asp Pro Ser Lys Ile 
        915                 920                 925             


Thr Glu Glu Ala Ser Gln His Lys Ile Gln Glu Leu Leu Arg Ala Ile 
    930                 935                 940                 


Ala Asn Glu Pro Glu Lys Glu Asn Asp Asn Tyr Leu Lys Tyr Ile Lys 
945                 950                 955                 960 


Ala Leu Leu Leu 
                


<210> 7
<211> 1018
<212> PRT
<213> Saccharomyces cerevisiae S288C

<400> 7
Met Ala Gly Gln Pro Thr Ile Ser Arg Phe Phe Lys Lys Ala Val Lys 
1               5                   10                  15      


Ser Glu Leu Thr His Lys Gln Glu Gln Glu Val Ala Val Gly Asn Gly 
            20                  25                  30          


Ala Gly Ser Glu Ser Ile Cys Leu Asp Thr Asp Glu Glu Asp Asn Leu 
        35                  40                  45              


Ser Ser Val Ala Ser Thr Thr Val Thr Asn Asp Ser Phe Pro Leu Lys 
    50                  55                  60                  


Gly Ser Val Ser Ser Lys Asn Ser Lys Asn Ser Glu Lys Thr Ser Gly 
65                  70                  75                  80  


Thr Ser Thr Thr Phe Asn Asp Ile Asp Phe Ala Lys Lys Leu Asp Arg 
                85                  90                  95      


Ile Met Lys Arg Arg Ser Asp Glu Asn Val Glu Ala Glu Asp Asp Glu 
            100                 105                 110         


Glu Glu Gly Glu Glu Asp Phe Val Lys Lys Lys Ala Arg Lys Ser Pro 
        115                 120                 125             


Thr Ala Lys Leu Thr Pro Leu Asp Lys Gln Val Lys Asp Leu Lys Met 
    130                 135                 140                 


His His Arg Asp Lys Val Leu Val Ile Arg Val Gly Tyr Lys Tyr Lys 
145                 150                 155                 160 


Cys Phe Ala Glu Asp Ala Val Thr Val Ser Arg Ile Leu His Ile Lys 
                165                 170                 175     


Leu Val Pro Gly Lys Leu Thr Ile Asp Glu Ser Asn Pro Gln Asp Cys 
            180                 185                 190         


Asn His Arg Gln Phe Ala Tyr Cys Ser Phe Pro Asp Val Arg Leu Asn 
        195                 200                 205             


Val His Leu Glu Arg Leu Val His His Asn Leu Lys Val Ala Val Val 
    210                 215                 220                 


Glu Gln Ala Glu Thr Ser Ala Ile Lys Lys His Asp Pro Gly Ala Ser 
225                 230                 235                 240 


Lys Ser Ser Val Phe Glu Arg Lys Ile Ser Asn Val Phe Thr Lys Ala 
                245                 250                 255     


Thr Phe Gly Val Asn Ser Thr Phe Val Leu Arg Gly Lys Arg Ile Leu 
            260                 265                 270         


Gly Asp Thr Asn Ser Ile Trp Ala Leu Ser Arg Asp Val His Gln Gly 
        275                 280                 285             


Lys Val Ala Lys Tyr Ser Leu Ile Ser Val Asn Leu Asn Asn Gly Glu 
    290                 295                 300                 


Val Val Tyr Asp Glu Phe Glu Glu Pro Asn Leu Ala Asp Glu Lys Leu 
305                 310                 315                 320 


Gln Ile Arg Ile Lys Tyr Leu Gln Pro Ile Glu Val Leu Val Asn Thr 
                325                 330                 335     


Asp Asp Leu Pro Leu His Val Ala Lys Phe Phe Lys Asp Ile Ser Cys 
            340                 345                 350         


Pro Leu Ile His Lys Gln Glu Tyr Asp Leu Glu Asp His Val Val Gln 
        355                 360                 365             


Ala Ile Lys Val Met Asn Glu Lys Ile Gln Leu Ser Pro Ser Leu Ile 
    370                 375                 380                 


Arg Leu Val Ser Lys Leu Tyr Ser His Met Val Glu Tyr Asn Asn Glu 
385                 390                 395                 400 


Gln Val Met Leu Ile Pro Ser Ile Tyr Ser Pro Phe Ala Ser Lys Ile 
                405                 410                 415     


His Met Leu Leu Asp Pro Asn Ser Leu Gln Ser Leu Asp Ile Phe Thr 
            420                 425                 430         


His Asp Gly Gly Lys Gly Ser Leu Phe Trp Leu Leu Asp His Thr Arg 
        435                 440                 445             


Thr Ser Phe Gly Leu Arg Met Leu Arg Glu Trp Ile Leu Lys Pro Leu 
    450                 455                 460                 


Val Asp Val His Gln Ile Glu Glu Arg Leu Asp Ala Ile Glu Cys Ile 
465                 470                 475                 480 


Thr Ser Glu Ile Asn Asn Ser Ile Phe Phe Glu Ser Leu Asn Gln Met 
                485                 490                 495     


Leu Asn His Thr Pro Asp Leu Leu Arg Thr Leu Asn Arg Ile Met Tyr 
            500                 505                 510         


Gly Thr Thr Ser Arg Lys Glu Val Tyr Phe Tyr Leu Lys Gln Ile Thr 
        515                 520                 525             


Ser Phe Val Asp His Phe Lys Met His Gln Ser Tyr Leu Ser Glu His 
    530                 535                 540                 


Phe Lys Ser Ser Asp Gly Arg Ile Gly Lys Gln Ser Pro Leu Leu Phe 
545                 550                 555                 560 


Arg Leu Phe Ser Glu Leu Asn Glu Leu Leu Ser Thr Thr Gln Leu Pro 
                565                 570                 575     


His Phe Leu Thr Met Ile Asn Val Ser Ala Val Met Glu Lys Asn Ser 
            580                 585                 590         


Asp Lys Gln Val Met Asp Phe Phe Asn Leu Asn Asn Tyr Asp Cys Ser 
        595                 600                 605             


Glu Gly Ile Ile Lys Ile Gln Arg Glu Ser Glu Ser Val Arg Ser Gln 
    610                 615                 620                 


Leu Lys Glu Glu Leu Ala Glu Ile Arg Lys Tyr Leu Lys Arg Pro Tyr 
625                 630                 635                 640 


Leu Asn Phe Arg Asp Glu Val Asp Tyr Leu Ile Glu Val Lys Asn Ser 
                645                 650                 655     


Gln Ile Lys Asp Leu Pro Asp Asp Trp Ile Lys Val Asn Asn Thr Lys 
            660                 665                 670         


Met Val Ser Arg Phe Thr Thr Pro Arg Thr Gln Lys Leu Thr Gln Lys 
        675                 680                 685             


Leu Glu Tyr Tyr Lys Asp Leu Leu Ile Arg Glu Ser Glu Leu Gln Tyr 
    690                 695                 700                 


Lys Glu Phe Leu Asn Lys Ile Thr Ala Glu Tyr Thr Glu Leu Arg Lys 
705                 710                 715                 720 


Ile Thr Leu Asn Leu Ala Gln Tyr Asp Cys Ile Leu Ser Leu Ala Ala 
                725                 730                 735     


Thr Ser Cys Asn Val Asn Tyr Val Arg Pro Thr Phe Val Asn Gly Gln 
            740                 745                 750         


Gln Ala Ile Ile Ala Lys Asn Ala Arg Asn Pro Ile Ile Glu Ser Leu 
        755                 760                 765             


Asp Val His Tyr Val Pro Asn Asp Ile Met Met Ser Pro Glu Asn Gly 
    770                 775                 780                 


Lys Ile Asn Ile Ile Thr Gly Pro Asn Met Gly Gly Lys Ser Ser Tyr 
785                 790                 795                 800 


Ile Arg Gln Val Ala Leu Leu Thr Ile Met Ala Gln Ile Gly Ser Phe 
                805                 810                 815     


Val Pro Ala Glu Glu Ile Arg Leu Ser Ile Phe Glu Asn Val Leu Thr 
            820                 825                 830         


Arg Ile Gly Ala His Asp Asp Ile Ile Asn Gly Asp Ser Thr Phe Lys 
        835                 840                 845             


Val Glu Met Leu Asp Ile Leu His Ile Leu Lys Asn Cys Asn Lys Arg 
    850                 855                 860                 


Ser Leu Leu Leu Leu Asp Glu Val Gly Arg Gly Thr Gly Thr His Asp 
865                 870                 875                 880 


Gly Ile Ala Ile Ser Tyr Ala Leu Ile Lys Tyr Phe Ser Glu Leu Ser 
                885                 890                 895     


Asp Cys Pro Leu Ile Leu Phe Thr Thr His Phe Pro Met Leu Gly Glu 
            900                 905                 910         


Ile Lys Ser Pro Leu Ile Arg Asn Tyr His Met Asp Tyr Val Glu Glu 
        915                 920                 925             


Gln Lys Thr Gly Glu Asp Trp Met Ser Val Ile Phe Leu Tyr Lys Leu 
    930                 935                 940                 


Lys Lys Gly Leu Thr Tyr Asn Ser Tyr Gly Met Asn Val Ala Lys Leu 
945                 950                 955                 960 


Ala Arg Leu Asp Lys Asp Ile Ile Asn Arg Ala Phe Ser Ile Ser Glu 
                965                 970                 975     


Glu Leu Arg Lys Glu Ser Ile Asn Glu Asp Ala Leu Lys Leu Phe Ser 
            980                 985                 990         


Ser Leu Lys Arg Ile Leu Lys Ser  Asp Asn Ile Thr Ala  Thr Asp Lys 
        995                 1000                 1005             


Leu Ala  Lys Leu Leu Ser Leu  Asp Ile His 
    1010                 1015             


<210> 8
<211> 1242
<212> PRT
<213> Saccharomyces cerevisiae

<400> 8
Met Ala Pro Ala Thr Pro Lys Thr Ser Lys Thr Ala His Phe Lys Asn 
1               5                   10                  15      


Gly Ser Thr Ser Ser Gln Lys Lys Met Lys Gln Ser Ser Leu Leu Ser 
            20                  25                  30          


Phe Phe Ser Lys Gln Val Pro Ser Gly Thr Pro Ser Lys Lys Val Gln 
        35                  40                  45              


Lys Pro Thr Pro Ala Thr Leu Glu Asn Thr Ala Thr Asp Lys Ile Thr 
    50                  55                  60                  


Lys Asn Pro Glu Gly Gly Lys Thr Gly Lys Leu Phe Val Asp Ala Asp 
65                  70                  75                  80  


Glu Asp Asn Asp Leu Thr Ile Ala Glu Glu Thr Val Ser Thr Val Arg 
                85                  90                  95      


Ser Asp Ile Met His Ser Gln Glu Pro Gln Ser Asp Thr Met Leu Asn 
            100                 105                 110         


Ser Asn Thr Thr Glu Pro Lys Ser Thr Thr Thr Asp Glu Asp Leu Ser 
        115                 120                 125             


Ser Ser Gln Ser Arg Arg Asn His Lys Arg Arg Leu Asn Tyr Ala Glu 
    130                 135                 140                 


Ser Asp Asp Asp Asp Ser Asp Thr Thr Phe Thr Ala Lys Arg Lys Lys 
145                 150                 155                 160 


Gly Lys Val Val Asp Ser Glu Ser Asp Glu Asp Glu Tyr Leu Pro Asp 
                165                 170                 175     


Lys Asn Asp Gly Asp Glu Asp Asp Asp Ile Ala Asp Asp Lys Glu Asp 
            180                 185                 190         


Ile Lys Gly Glu Leu Ala Glu Asp Ser Gly Asp Asp Asp Asp Leu Ile 
        195                 200                 205             


Ser Leu Ala Glu Thr Thr Ser Lys Lys Lys Phe Ser Tyr Asn Thr Ser 
    210                 215                 220                 


His Ser Ser Ser Pro Phe Thr Arg Asn Ile Ser Arg Asn Asn Ser Lys 
225                 230                 235                 240 


Lys Lys Ser Arg Pro Asn Gln Ala Pro Ser Arg Ser Tyr Asn Pro Ser 
                245                 250                 255     


His Ser Gln Pro Ser Ala Thr Ser Lys Ser Ser Lys Phe Asn Lys Gln 
            260                 265                 270         


Asn Glu Glu Arg Tyr Gln Trp Leu Val Asp Glu Arg Asp Ala Gln Arg 
        275                 280                 285             


Arg Pro Lys Ser Asp Pro Glu Tyr Asp Pro Arg Thr Leu Tyr Ile Pro 
    290                 295                 300                 


Ser Ser Ala Trp Asn Lys Phe Thr Pro Phe Glu Lys Gln Tyr Trp Glu 
305                 310                 315                 320 


Ile Lys Ser Lys Met Trp Asp Cys Ile Val Phe Phe Lys Lys Gly Lys 
                325                 330                 335     


Phe Phe Glu Leu Tyr Glu Lys Asp Ala Leu Leu Ala Asn Ala Leu Phe 
            340                 345                 350         


Asp Leu Lys Ile Ala Gly Gly Gly Arg Ala Asn Met Gln Leu Ala Gly 
        355                 360                 365             


Ile Pro Glu Met Ser Phe Glu Tyr Trp Ala Ala Gln Phe Ile Gln Met 
    370                 375                 380                 


Gly Tyr Lys Val Ala Lys Val Asp Gln Arg Glu Ser Met Leu Ala Lys 
385                 390                 395                 400 


Glu Met Arg Glu Gly Ser Lys Gly Ile Val Lys Arg Glu Leu Gln Cys 
                405                 410                 415     


Ile Leu Thr Ser Gly Thr Leu Thr Asp Gly Asp Met Leu His Ser Asp 
            420                 425                 430         


Leu Ala Thr Phe Cys Leu Ala Ile Arg Glu Glu Pro Gly Asn Phe Tyr 
        435                 440                 445             


Asn Glu Thr Gln Leu Asp Ser Ser Thr Ile Val Gln Lys Leu Asn Thr 
    450                 455                 460                 


Lys Ile Phe Gly Ala Ala Phe Ile Asp Thr Ala Thr Gly Glu Leu Gln 
465                 470                 475                 480 


Met Leu Glu Phe Glu Asp Asp Ser Glu Cys Thr Lys Leu Asp Thr Leu 
                485                 490                 495     


Met Ser Gln Val Arg Pro Met Glu Val Val Met Glu Arg Asn Asn Leu 
            500                 505                 510         


Ser Thr Leu Ala Asn Lys Ile Val Lys Phe Asn Ser Ala Pro Asn Ala 
        515                 520                 525             


Ile Phe Asn Glu Val Lys Ala Gly Glu Glu Phe Tyr Asp Cys Asp Lys 
    530                 535                 540                 


Thr Tyr Ala Glu Ile Ile Ser Ser Glu Tyr Phe Ser Thr Glu Glu Asp 
545                 550                 555                 560 


Trp Pro Glu Val Leu Lys Ser Tyr Tyr Asp Thr Gly Lys Lys Val Gly 
                565                 570                 575     


Phe Ser Ala Phe Gly Gly Leu Leu Tyr Tyr Leu Lys Trp Leu Lys Leu 
            580                 585                 590         


Asp Lys Asn Leu Ile Ser Met Lys Asn Ile Lys Glu Tyr Asp Phe Val 
        595                 600                 605             


Lys Ser Gln His Ser Met Val Leu Asp Gly Ile Thr Leu Gln Asn Leu 
    610                 615                 620                 


Glu Ile Phe Ser Asn Ser Phe Asp Gly Ser Asp Lys Gly Thr Leu Phe 
625                 630                 635                 640 


Lys Leu Phe Asn Arg Ala Ile Thr Pro Met Gly Lys Arg Met Met Lys 
                645                 650                 655     


Lys Trp Leu Met His Pro Leu Leu Arg Lys Asn Asp Ile Glu Ser Arg 
            660                 665                 670         


Leu Asp Ser Val Asp Ser Leu Leu Gln Asp Ile Thr Leu Arg Glu Gln 
        675                 680                 685             


Leu Glu Ile Thr Phe Ser Lys Leu Pro Asp Leu Glu Arg Met Leu Ala 
    690                 695                 700                 


Arg Ile His Ser Arg Thr Ile Lys Val Lys Asp Phe Glu Lys Val Ile 
705                 710                 715                 720 


Thr Ala Phe Glu Thr Ile Ile Glu Leu Gln Asp Ser Leu Lys Ser Asn 
                725                 730                 735     


Asp Leu Lys Gly Asp Val Ser Lys Tyr Ile Ser Ser Phe Pro Glu Gly 
            740                 745                 750         


Leu Val Glu Ala Val Lys Ser Trp Thr Asn Ala Phe Glu Arg Gln Lys 
        755                 760                 765             


Ala Ile Asn Glu Asn Ile Ile Val Pro Gln Arg Gly Phe Asp Ile Glu 
    770                 775                 780                 


Phe Asp Lys Ser Met Asp Arg Ile Gln Glu Leu Glu Asp Glu Leu Met 
785                 790                 795                 800 


Glu Ile Leu Met Thr Tyr Arg Lys Gln Phe Lys Cys Ser Asn Ile Gln 
                805                 810                 815     


Tyr Lys Asp Ser Gly Lys Glu Ile Tyr Thr Ile Glu Ile Pro Ile Ser 
            820                 825                 830         


Ala Thr Lys Asn Val Pro Ser Asn Trp Val Gln Met Ala Ala Asn Lys 
        835                 840                 845             


Thr Tyr Lys Arg Tyr Tyr Ser Asp Glu Val Arg Ala Leu Ala Arg Ser 
    850                 855                 860                 


Met Ala Glu Ala Lys Glu Ile His Lys Thr Leu Glu Glu Asp Leu Lys 
865                 870                 875                 880 


Asn Arg Leu Cys Gln Lys Phe Asp Ala His Tyr Asn Thr Ile Trp Met 
                885                 890                 895     


Pro Thr Ile Gln Ala Ile Ser Asn Ile Asp Cys Leu Leu Ala Ile Thr 
            900                 905                 910         


Arg Thr Ser Glu Tyr Leu Gly Ala Pro Ser Cys Arg Pro Thr Ile Val 
        915                 920                 925             


Asp Glu Val Asp Ser Lys Thr Asn Thr Gln Leu Asn Gly Phe Leu Lys 
    930                 935                 940                 


Phe Lys Ser Leu Arg His Pro Cys Phe Asn Leu Gly Ala Thr Thr Ala 
945                 950                 955                 960 


Lys Asp Phe Ile Pro Asn Asp Ile Glu Leu Gly Lys Glu Gln Pro Arg 
                965                 970                 975     


Leu Gly Leu Leu Thr Gly Ala Asn Ala Ala Gly Lys Ser Thr Ile Leu 
            980                 985                 990         


Arg Met Ala Cys Ile Ala Val Ile  Met Ala Gln Met Gly  Cys Tyr Val 
        995                 1000                 1005             


Pro Cys  Glu Ser Ala Val Leu  Thr Pro Ile Asp Arg  Ile Met Thr 
    1010                 1015                 1020             


Arg Leu  Gly Ala Asn Asp Asn  Ile Met Gln Gly Lys  Ser Thr Phe 
    1025                 1030                 1035             


Phe Val  Glu Leu Ala Glu Thr  Lys Lys Ile Leu Asp  Met Ala Thr 
    1040                 1045                 1050             


Asn Arg  Ser Leu Leu Val Val  Asp Glu Leu Gly Arg  Gly Gly Ser 
    1055                 1060                 1065             


Ser Ser  Asp Gly Phe Ala Ile  Ala Glu Ser Val Leu  His His Val 
    1070                 1075                 1080             


Ala Thr  His Ile Gln Ser Leu  Gly Phe Phe Ala Thr  His Tyr Gly 
    1085                 1090                 1095             


Thr Leu  Ala Ser Ser Phe Lys  His His Pro Gln Val  Arg Pro Leu 
    1100                 1105                 1110             


Lys Met  Ser Ile Leu Val Asp  Glu Ala Thr Arg Asn  Val Thr Phe 
    1115                 1120                 1125             


Leu Tyr  Lys Met Leu Glu Gly  Gln Ser Glu Gly Ser  Phe Gly Met 
    1130                 1135                 1140             


His Val  Ala Ser Met Cys Gly  Ile Ser Lys Glu Ile  Ile Asp Asn 
    1145                 1150                 1155             


Ala Gln  Ile Ala Ala Asp Asn  Leu Glu His Thr Ser  Arg Leu Val 
    1160                 1165                 1170             


Lys Glu  Arg Asp Leu Ala Ala  Asn Asn Leu Asn Gly  Glu Val Val 
    1175                 1180                 1185             


Ser Val  Pro Gly Gly Leu Gln  Ser Asp Phe Val Arg  Ile Ala Tyr 
    1190                 1195                 1200             


Gly Asp  Gly Leu Lys Asn Thr  Lys Leu Gly Ser Gly  Glu Ala Val 
    1205                 1210                 1215             


Leu Asn  Tyr Asp Trp Asn Ile  Lys Arg Asn Val Leu  Lys Ser Leu 
    1220                 1225                 1230             


Phe Ser  Ile Ile Asp Asp Leu  Gln Ser 
    1235                 1240         


<210> 9
<211> 209
<212> PRT
<213> Saccharomyces cerevisiae S288C

<400> 9
Met Ala Pro Ser Ile Ala Thr Val Lys Ile Ala Arg Asp Met Val Leu 
1               5                   10                  15      


Pro Leu Arg Ile Phe Val Asn Arg Lys Gln Ile Leu Gln Thr Asn Asp 
            20                  25                  30          


Lys Thr Ser Asn Lys Ser Asn Ala Thr Ile Phe Glu Ala Pro Leu Leu 
        35                  40                  45              


Ser Asn Asn Ser Ile Ile Cys Leu Lys Ser Pro Asn Thr Arg Ile Tyr 
    50                  55                  60                  


Leu Ser Gln Gln Asp Lys Lys Asn Leu Cys Asp Glu Ile Lys Glu Asp 
65                  70                  75                  80  


Leu Leu Leu Ile Val Tyr Glu Leu Ala Ser Pro Glu Ile Ile Ser Ser 
                85                  90                  95      


Val Leu Ser Lys Ile Arg Val Gly His Ser Thr Asp Phe Gln Ile Asn 
            100                 105                 110         


Val Leu Pro Lys Leu Phe Ala Gly Ala Asp Thr Asp Asn Ala Val Thr 
        115                 120                 125             


Ser His Ile Gln Ser Val Thr Arg Leu Ala Lys Phe Lys Tyr Lys Leu 
    130                 135                 140                 


His Tyr Lys His Lys Trp Glu Leu Asp Ile Phe Ile Asn Ser Ile Lys 
145                 150                 155                 160 


Lys Ile Ala Asn Leu Arg His Tyr Leu Met Phe Gln Thr Leu Thr Leu 
                165                 170                 175     


Asn Gly Phe Ser Leu Asn Ala Gly Pro Lys Thr Leu Leu Ala Arg Lys 
            180                 185                 190         


Ile Glu Lys Gln Pro Gln Val Pro Asn Leu Leu Ile Glu Asn Gly Asp 
        195                 200                 205             


Ala 
    


<210> 10
<211> 231
<212> PRT
<213> Homo sapiens

<400> 10
Met Phe Ile Leu Thr Pro Lys Leu Gln Ile Pro Ala Thr Phe Asp Gly 
1               5                   10                  15      


Met Ala Asn Val Lys Ala Ala Pro Lys Ile Ile Asp Thr Gly Gly Gly 
            20                  25                  30          


Phe Ile Leu Glu Glu Glu Glu Glu Glu Glu Gln Lys Ile Gly Lys Val 
        35                  40                  45              


Val His Gln Pro Gly Pro Val Met Glu Phe Asp Tyr Val Ile Cys Glu 
    50                  55                  60                  


Glu Cys Gly Lys Glu Phe Met Asp Ser Tyr Leu Met Asn His Phe Asp 
65                  70                  75                  80  


Leu Pro Thr Cys Asp Asn Cys Arg Asp Ala Asp Asp Lys His Lys Leu 
                85                  90                  95      


Ile Thr Lys Thr Glu Ala Lys Gln Glu Tyr Leu Leu Lys Asp Cys Asp 
            100                 105                 110         


Leu Glu Lys Arg Glu Pro Pro Leu Lys Phe Ile Val Lys Lys Asn Pro 
        115                 120                 125             


His His Ser Gln Trp Gly Asp Met Lys Leu Tyr Leu Lys Leu Gln Ile 
    130                 135                 140                 


Val Lys Arg Ser Leu Glu Val Trp Gly Ser Gln Glu Ala Leu Glu Glu 
145                 150                 155                 160 


Ala Lys Glu Val Arg Gln Glu Asn Arg Glu Lys Met Lys Gln Lys Lys 
                165                 170                 175     


Phe Asp Lys Lys Val Lys Glu Leu Arg Arg Ala Val Arg Ser Ser Val 
            180                 185                 190         


Trp Lys Arg Glu Thr Ile Val His Gln His Glu Tyr Gly Pro Glu Glu 
        195                 200                 205             


Asn Leu Glu Asp Asp Met Tyr Arg Lys Thr Cys Thr Met Cys Gly His 
    210                 215                 220                 


Glu Leu Thr Tyr Glu Lys Met 
225                 230     


