                         SEQUENCE LISTING

<110>  ATHERTON, Matthew John
       LICHTY, Brian
 
<120>  Combination Prime:Boost Therapy

<130>  PAT 104130W-90

<140>  PCT/CA2018/051329
<141>  2018-10-19

<150>  US 62/575,215
<151>  2017-10-20

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  1

Lys Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln 
1               5                   10                  15  


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  2

Val Tyr Asp Phe Ala Phe Arg Asp Leu 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  3

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  4

Lys Leu Pro Gln Leu Cys Thr Glu Leu 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  5

Thr Ile His Asp Ile Ile Leu Glu Cys Val 
1               5                   10  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  6

Phe Ala Phe Arg Asp Leu Cys Ile Val 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  7

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  8

Leu Leu Met Gly Thr Leu Gly Ile Val 
1               5                   


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  9

Thr Leu Gly Ile Val Pro Ile 
1               5           


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  10

Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  11

Leu Phe Leu Asn Thr Leu Ser Phe Val Pro Trp Cys Ala Ser 
1               5                   10                  


<210>  12
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  12

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  13

Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile 
1               5                   10                  15      


Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr 
            20                  25                  30          


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  14

Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp 
1               5                   10                  15      


Leu Cys Ile Val Tyr Arg Asp Gly Asn 
            20                  25  


<210>  15
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  15

Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg 
1               5                   10                  15      


Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
            20                  25                  30          


<210>  16
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  16

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
            20                  25                  30          


Asp Ile Arg 
        35  


<210>  17
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  17

Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Asp 
1               5                   10                  15      


Lys Leu Lys Phe Tyr Ser Lys Ile 
            20                  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  18

Asp Lys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys 
1               5                   10                  15      


Tyr Ser Val Tyr Gly Thr Thr Leu 
            20                  


<210>  19
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  19

His Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn 
1               5                   10                  15      


Lys Pro Leu Cys Asp Leu Leu Ile Arg 
            20                  25  


<210>  20
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  20

Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu 
1               5                   10                  15      


Leu Ile Arg Ile Asn Gln Lys Pro Leu Cys Pro Glu Glu Lys 
            20                  25                  30  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  21

Arg Ile Asn Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu 
1               5                   10                  15      


Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr 
            20                  25                  30  


<210>  22
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  22

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Gln Leu Asn Asp Ser Ser Glu Glu Glu 
            20                  25                  30          


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  23

Leu Tyr Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly 
1               5                   10                  15      


Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr 
            20                  25                  30          


<210>  24
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  24

Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu 
1               5                   10                  15      


Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Pro Ile Cys Ser Gln 
            20                  25                  30          


Lys Pro 
        


<210>  25
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  25

Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys 
1               5                   10                  15      


Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
            20                  25      


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  26

Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr 
1               5                   10                  15      


Cys Tyr Ser Leu Tyr Gly Thr Thr Leu 
            20                  25  


<210>  27
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  27

His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn 
1               5                   10                  15      


Lys Pro Leu Cys Asp Leu Leu Ile Arg 
            20                  25  


<210>  28
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  28

Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu 
1               5                   10                  15      


Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys 
            20                  25                  30          


<210>  29
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  29

Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg 
1               5                   10                  15      


His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr 
            20                  25                  30          


<210>  30
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  30

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu 
        35  


<210>  31
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  31

Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu 
1               5                   10                  15      


Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn 
            20                  25                  30          


Ile Val Thr 
        35  


<210>  32
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  32

Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu 
1               5                   10                  15      


Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser 
            20                  25                  30          


Gln Lys Pro 
        35  


<210>  33
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  33

Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Lys 
1               5                   10                  15      


Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu 
            20                  25                  30          


Phe Leu Asn Thr Leu Ser Phe Val Pro Trp Cys Ala Ser 
        35                  40                  45  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope flanking sequence

<400>  34

Met Ser Ile Gln Met Leu Ala Gln Val Ile Lys Glu 
1               5                   10          


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope flanking sequence

<400>  35

Lys Ile Leu Met Phe Lys Leu Asn Ala Pro Ala 
1               5                   10      


<210>  36
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  36

Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala Asp 
1               5                   10                  15      


Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu 
            20                  25                  


<210>  37
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  37

Ile Ile Leu Glu Cys Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val 
1               5                   10                  15      


Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn 
            20                  25                  30          


Pro Tyr Ala Val Cys Asp Lys 
        35                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  38

Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe 
1               5                   10                  15      


Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr 
            20                  25                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  39

Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg 
1               5                   10                  15      


Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu 
            20                  25                  30          


Arg Leu Cys Val Gln Ser Thr 
        35                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigenic protein sequence

<400>  40

Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile 
1               5                   10                  15      


Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu 
            20                  25                  


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteasomally degradeable linker

<400>  41

Gly Gly Gly Gly Gly Ala Ala Tyr 
1               5               


<210>  42
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E6 protein domain


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (143)..(143)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (146)..(146)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Xaa Val Tyr Xaa Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Xaa Asp Lys Xaa Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Xaa Ile Asn 
            100                 105                 110         


Xaa Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Xaa Met 
    130                 135                 140                 


Ser Xaa Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  43
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV18 E6 protein domain


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (65)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (65)..(68)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (141)..(141)
<223>  Xaa can be any naturally occurring amino acid

<400>  43

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Xaa 
            20                  25                  30          


Val Tyr Xaa Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Xaa His Lys Xaa Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Xaa Leu Arg Xaa Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly His Tyr Arg Gly Gln Xaa His Ser Xaa Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  44
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E7 protein domain


<220>
<221>  MISC_FEATURE
<222>  (24)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Xaa Xaa Xaa Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Xaa Pro Ile Xaa Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  45
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV18 E7 protein domain


<220>
<221>  MISC_FEATURE
<222>  (27)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Xaa Xaa Xaa Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Xaa Pro Trp Xaa Ala Ser Gln Gln 
            100                 105 


<210>  46
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary HPV E6/E7 protein domain

<400>  46

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Asp Lys Leu Lys Phe Tyr Ser Lys Ile Ser Glu 
65                  70                  75                  80  


Tyr Arg His Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln 
                85                  90                  95      


Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Ile Asn Gln Lys Pro 
            100                 105                 110         


Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe 
        115                 120                 125             


His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg 
    130                 135                 140                 


Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 


<210>  47
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary HPV E6/E7 protein domain

<400>  47

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


His Lys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His Tyr Ser 
65                  70                  75                  80  


Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly Leu 
                85                  90                  95      


Tyr Asn Leu Leu Ile Arg Leu Arg Gln Lys Pro Leu Asn Pro Ala Glu 
            100                 105                 110         


Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His Asn Ile Ala Gly 
        115                 120                 125             


His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln Glu 
    130                 135                 140                 


Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 


<210>  48
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary HPV E6/E7 protein domain

<400>  48

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Gln Leu Asn Asp Ser Ser Glu Glu Glu 
            20                  25                  30          


Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His 
        35                  40                  45              


Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu 
    50                  55                  60                  


Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu 
65                  70                  75                  80  


Met Gly Thr Leu Gly Ile Val Pro Ile Cys Ser Gln Lys Pro 
                85                  90                  


<210>  49
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary HPV E6/E7 protein domain

<400>  49

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Gln Leu Ser Asp Ser Glu 
            20                  25                  30          


Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu Pro Ala 
        35                  40                  45              


Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys 
    50                  55                  60                  


Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala Asp Asp Leu 
65                  70                  75                  80  


Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Pro Trp 
                85                  90                  95      


Cys Ala Ser Gln Gln 
            100     


<210>  50
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary HPV E6/E7 fusion protein

<400>  50

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Asp Lys Leu Lys Phe Tyr Ser Lys Ile Ser Glu 
65                  70                  75                  80  


Tyr Arg His Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln 
                85                  90                  95      


Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Ile Asn Gln Lys Pro 
            100                 105                 110         


Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe 
        115                 120                 125             


His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg 
    130                 135                 140                 


Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu Gly Gly Gly Gly Gly Ala 
145                 150                 155                 160 


Ala Tyr Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu 
                165                 170                 175     


Pro Asp Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile 
            180                 185                 190         


Thr Cys Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu 
        195                 200                 205             


Phe Ala Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His 
    210                 215                 220                 


Ala Ala His Lys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
225                 230                 235                 240 


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                245                 250                 255     


Gly Leu Tyr Asn Leu Leu Ile Arg Leu Arg Gln Lys Pro Leu Asn Pro 
            260                 265                 270         


Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His Asn Ile 
        275                 280                 285             


Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg 
    290                 295                 300                 


Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Ala Ala Tyr Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met 
                325                 330                 335     


Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gln Leu Asn Asp Ser 
            340                 345                 350         


Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro 
        355                 360                 365             


Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser 
    370                 375                 380                 


Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu 
385                 390                 395                 400 


Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Pro Ile Cys Ser Gln 
                405                 410                 415     


Lys Pro Gly Gly Gly Gly Gly Ala Ala Tyr Met His Gly Pro Lys Ala 
            420                 425                 430         


Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro 
        435                 440                 445             


Val Asp Leu Leu Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile 
    450                 455                 460                 


Asp Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln 
465                 470                 475                 480 


Arg His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Lys 
                485                 490                 495     


Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu 
            500                 505                 510         


Phe Leu Asn Thr Leu Ser Phe Val Pro Trp Cys Ala Ser Gln Gln 
        515                 520                 525         


<210>  51
<211>  1584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding exemplary HPV E6/E7 fusion protein

<400>  51
atgcatcaga agcgaactgc tatgtttcag gaccctcagg agcggccacg caaactgcct       60

cagctgtgca ccgaactgca gacaactatc cacgacatca ttctggaatg cgtgtactgt      120

aagcagcagc tgctgaggag agaggtctat gacttcgctt ttcgcgatct gtgcatcgtg      180

taccgagacg gaaacccata tgcagtcgat aagctgaagt tctacagcaa gatctccgaa      240

tacaggcatt actgttacag cgtgtacggg accacactgg agcagcagta taacaagccc      300

ctgtgcgacc tgctgatcag aattaatcag aagcccctgt gccctgagga aaaacagagg      360

cacctggata agaaacagag atttcataac atccgaggac gatggaccgg gcggtgcatg      420

tcctgctgta gaagctcccg gactcgacga gagacccagc tgggcggagg aggaggagca      480

gcttacatgg cacgattcga ggaccctacc cgaaggccat ataagctgcc cgacctgtgc      540

acagaactga atacttctct gcaggacatc gagattacat gcgtgtactg taaaaccgtc      600

ctggagctga cagaagtgtt cgagtttgct ttcaaggacc tgtttgtggt ctaccgggat      660

tcaatccctc acgcagccca taaaatcgac ttctacagca ggatcaggga actgcgccac      720

tactccgaca gcgtgtacgg ggatacactg gagaagctga caaacactgg cctgtacaat      780

ctgctgatcc gactgcgaca gaagccactg aacccagccg aaaaactgag acacctgaac      840

gagaagagac ggtttcacaa tattgcaggc cattataggg gacagtgcca tagttgctgt      900

aatcgagcca ggcaggaaag actgcagcgc cgaagggaga ctcaagtcgg cggaggagga      960

ggagctgcat acatgcacgg cgacaccccc acactgcatg aatatatgct ggatctgcag     1020

cctgagacta ccgacctgta ccagctgaac gattctagtg aggaagagga cgaaatcgac     1080

ggaccagcag gacaggcaga gcctgaccgg gcccactata atattgtgac attctgctgt     1140

aagtgcgatt ctactctgcg gctgtgcgtg cagagtactc atgtcgacat ccgcaccctg     1200

gaggatctgc tgatggggac tctgggcatc gtcccaattt gtagccagaa accaggcggc     1260

ggcggcggag cagcttacat gcacggaccc aaggctaccc tgcaggacat cgtgctgcat     1320

ctggaacctc agaatgagat tccagtcgac ctgctgcagc tgagtgattc agaagaggaa     1380

aacgacgaga tcgacggcgt gaatcaccag catctgcctg ctagacgggc agagccacag     1440

cgacacacaa tgctgtgcat gtgctgtaag tgtgaagcca ggatcaagct ggtggtcgag     1500

tcaagcgccg acgatctgcg cgccttccag cagctgttcc tgaatactct gtcatttgtc     1560

ccttggtgtg cctcccagca gtga                                            1584


<210>  52
<211>  12754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maraba MG1 DNA sequence encoding an exemplary HPV-E6E7 fusion 
       protein

<400>  52
acgaagacaa acaaaccatt gatagaatta agaggctcat gaaaatcctt aacagcgttc       60

aaaatgtctg ttacagtcaa gagagtcatt gatgattcac tcatcacccc caaattgcct      120

gcgaatgagg accctgtgga gtaccctgct gattatttca aaaagtcccg tgatattccg      180

gtgtacataa acacgaccaa aagtttgtct gatttgcggg gctatgttta tcaaggccta      240

aagtcaggca acatctctat aattcatgtc aacagttatc tgtatgcagc attaaaagag      300

atcagaggaa aattggacag agattggatc acctttggta tccaaatcgg aaaaacagga      360

gatagcgtgg ggatattcga tttactgacc ctaaaacctc tagatggtgt tttaccagat      420

ggggtgtctg atgctactcg aactagctca gacgatgcat ggcttccact gtatctattg      480

gggttataca gagttggtcg aacacagatg ccagaataca ggaagaagct gatggatggt      540

ctgattaatc aatgtaagat gatcaatgag cagtttgaac cactgttgcc agaaggaaga      600

gatgtctttg atgtctgggg aaatgacagc aattacacaa agattgtggc cgctgtagat      660

atgttcttcc atatgttcaa aaagcatgag aaggcctctt tcaggtatgg cacaatagtg      720

tcaagattta aggattgtgc agcattggct acatttggtc atctgtgtaa gatcactggt      780

atgtccactg aagatgtgac aacttggatt ctaaacaggg aggtggctga tgagatggtt      840

caaatgatgt acccaggaca ggagatagat aaggctgatt cttacatgcc ttatctaatc      900

gacttaggtc tgtcctcaaa atctccatat tcatcagtta aaaatccagc tttccatttt      960

tggggtcaat tgaccgcatt gttactgaga tcaaccagag ccagaaatgc acgtcagccg     1020

gatgacatcg agtatacatc cctgaccact gctgggctgt tgtatgcata tgccgttggt     1080

tcgtctgcag acctggctca acaattctac gttggggaca acaagtatgt gccagaaact     1140

ggagatggag gattaaccac caatgcaccg ccacaagggc gagatgtggt cgagtggctt     1200

agttggtttg aagatcaaaa cagaaaacct accccagaca tgctcatgta tgctaagaga     1260

gctgtcagtg ctttacaagg attgagggag aagacgattg gcaagtacgc caagtcagag     1320

tttgacaaat gacaactcac tcaccatatg tattactacc tttgcttcat atgaaaaaaa     1380

ctaacagcga tcatggatca gctatcaaag gtcaaggaat tccttaagac ttacgcgcag     1440

ttggatcaag cagtacaaga gatggatgac attgagtctc agagagagga aaagactaat     1500

tttgatttgt ttcaggaaga aggattggag attaaggaga agccttccta ttatcgggca     1560

gatgaagaag agattgattc agatgaagac agcgtggatg atgcacaaga cttagggata     1620

cgtacatcaa caagtcccat cgaggggtat gtggatgagg agcaggatga ttatgaggat     1680

gaggaagtga acgtggtgtt tacatcggac tggaaacagc ctgagctgga atccgacggg     1740

gatgggaaaa ctctccgatt gacgatacca gatggattga ctggggagca gaagtcgcaa     1800

tggcttgcca cgattaaggc agttgttcag agtgctaaat attggaacat ctcagaatgt     1860

tcatttgaga gttatgagca aggggttttg attagagaga gacaaatgac tcctgatgtc     1920

tacaaagtca ctcctgtttt aaatgctcca ccggttcaaa tgacagctaa tcaagatgtt     1980

tggtctctca gcagcactcc atttacattt ttgcccaaga aacaaggtgt gactccattg     2040

accatgtcct tagaagaact cttcaacacc cgaggtgaat tcatatctct gggaggaaac     2100

gggaaaatga gtcaccggga ggccatcatt ctagggttga gacacaagaa gctctataat     2160

caagccagac taaagtataa cttagcttga atatgaaaaa aactaacaga tatcaaaaga     2220

tatctctaac tcagtccatt gtgttcagtt caatcatgag ctctctcaag aaaattttgg     2280

gtattaaagg gaaagggaag aaatctaaga aattaggtat ggctccccca ccctatgaag     2340

aagagactcc aatggaatat tctccaagtg caccttatga taagtcattg tttggagtcg     2400

aagatatgga tttccatgat caacgtcaac tccgatatga gaaatttcac ttctcattga     2460

agatgactgt gagatcaaac aaaccatttc gaaattatga tgacgttgca gcagcggtgt     2520

ccaattggga tcatatgtac atcggcatgg caggaaaacg tcctttttat aagatattag     2580

cattcatggg ttctactcta ttgaaggcta caccagccgt ctgggctgac caaggacagc     2640

cagaatatca tgctcactgt gagggacgag cttacttgcc gcatcggtta gggccgaccc     2700

ctccgatgtt gaatgtccct gaacattttc gccgtccatt taacatcgga ttattcagag     2760

ggacaatcga cataaccctg gtacttttcg atgatgaatc tgtagattct gccccggtca     2820

tatgggatca ttttaatgca tccagattga gcagcttcag agaaaaggct ttgttgtttg     2880

gtttgattct agaaaagaaa gccactggga attgggtatt ggactctatt agtcatttca     2940

agtaattatc acaagtgttg aggtgatggg cagactatga aaaaaactaa cagggttcaa     3000

acactcttga tcgaggtacc cagttatatt tgttacaaca atgttgagac tttttctctt     3060

ttgtttcttg gccttaggag cccactccaa atttactata gtattccctc atcatcaaaa     3120

agggaattgg aagaatgtgc cttccacata tcattattgc ccttctagtt ctgaccagaa     3180

ttggcataat gatttgactg gagttagtct tcatgtgaaa attcccaaaa gtcacaaagc     3240

tatacaagca gatggctgga tgtgccacgc tgctaaatgg gtgactactt gtgacttcag     3300

atggtacgga cccaaataca tcacgcattc catacactct atgtcaccca ccctagaaca     3360

gtgcaagacc agtattgagc agacaaagca aggagtttgg attaatccag gctttccccc     3420

tcaaagctgc ggatatgcta cagtgacgga tgcagaggtg gttgttgtac aagcaacacc     3480

tcatcatgtg ttggttgatg agtacacagg agaatggatt gactcacaat tggtgggggg     3540

caaatgttcc aaggaggttt gtcaaacggt tcacaactcg accgtgtggc atgctgatta     3600

caagattaca gggctgtgcg agtcaaatct ggcatcagtg gatatcacct tcttctctga     3660

ggatggtcaa aagacgtctt tgggaaaacc gaacactgga ttcaggagta atcactttgc     3720

ttacgaaagt ggagagaagg catgccgtat gcagtactgc acacgatggg gaatccgact     3780

accttctgga gtatggtttg aattagtgga caaagatctc ttccaggcgg caaaattgcc     3840

tgaatgtcct agaggatcca gtatctcagc tccttctcag acttctgtgg atgttagttt     3900

gatacaagac gtagagagga tcttagatta ctctctatgc caggagacgt ggagtaagat     3960

acgagccaag cttcctgtat ctccagtaga tctgagttat ctcgccccaa aaaatccagg     4020

gagcggaccg gccttcacta tcattaatgg cactttgaaa tatttcgaaa caagatacat     4080

cagagttgac ataagtaatc ccatcatccc tcacatggtg ggaacaatga gtggaaccac     4140

gactgagcgt gaattgtgga atgattggta tccatatgaa gacgtagaga ttggtccaaa     4200

tggggtgttg aaaactccca ctggtttcaa gtttccgctg tacatgattg ggcacggaat     4260

gttggattcc gatctccaca aatcctccca ggctcaagtc ttcgaacatc cacacgcaaa     4320

ggacgctgca tcacagcttc ctgatgatga gactttattt tttggtgaca caggactatc     4380

aaaaaaccca gtagagttag tagaaggctg gttcagtagc tggaagagca cattggcatc     4440

gttctttctg attataggct tgggggttgc attaatcttc atcattcgaa ttattgttgc     4500

gattcgctat aaatacaagg ggaggaagac ccaaaaaatt tacaatgatg tcgagatgag     4560

tcgattggga aataaataac agatgacgca tgagggtcag atcagattta cagcgtaagt     4620

gtgatattta ggattataaa ggttccttaa ttttaatttg ttacgcgttg tatgaaaaaa     4680

actcatcaac agccatcatg catcagaagc gaactgctat gtttcaggac cctcaggagc     4740

ggccacgcaa actgcctcag ctgtgcaccg aactgcagac aactatccac gacatcattc     4800

tggaatgcgt gtactgtaag cagcagctgc tgaggagaga ggtctatgac ttcgcttttc     4860

gcgatctgtg catcgtgtac cgagacggaa acccatatgc agtcgataag ctgaagttct     4920

acagcaagat ctccgaatac aggcattact gttacagcgt gtacgggacc acactggagc     4980

agcagtataa caagcccctg tgcgacctgc tgatcagaat taatcagaag cccctgtgcc     5040

ctgaggaaaa acagaggcac ctggataaga aacagagatt tcataacatc cgaggacgat     5100

ggaccgggcg gtgcatgtcc tgctgtagaa gctcccggac tcgacgagag acccagctgg     5160

gcggaggagg aggagcagct tacatggcac gattcgagga ccctacccga aggccatata     5220

agctgcccga cctgtgcaca gaactgaata cttctctgca ggacatcgag attacatgcg     5280

tgtactgtaa aaccgtcctg gagctgacag aagtgttcga gtttgctttc aaggacctgt     5340

ttgtggtcta ccgggattca atccctcacg cagcccataa aatcgacttc tacagcagga     5400

tcagggaact gcgccactac tccgacagcg tgtacgggga tacactggag aagctgacaa     5460

acactggcct gtacaatctg ctgatccgac tgcgacagaa gccactgaac ccagccgaaa     5520

aactgagaca cctgaacgag aagagacggt ttcacaatat tgcaggccat tataggggac     5580

agtgccatag ttgctgtaat cgagccaggc aggaaagact gcagcgccga agggagactc     5640

aagtcggcgg aggaggagga gctgcataca tgcacggcga cacccccaca ctgcatgaat     5700

atatgctgga tctgcagcct gagactaccg acctgtacca gctgaacgat tctagtgagg     5760

aagaggacga aatcgacgga ccagcaggac aggcagagcc tgaccgggcc cactataata     5820

ttgtgacatt ctgctgtaag tgcgattcta ctctgcggct gtgcgtgcag agtactcatg     5880

tcgacatccg caccctggag gatctgctga tggggactct gggcatcgtc ccaatttgta     5940

gccagaaacc aggcggcggc ggcggagcag cttacatgca cggacccaag gctaccctgc     6000

aggacatcgt gctgcatctg gaacctcaga atgagattcc agtcgacctg ctgcagctga     6060

gtgattcaga agaggaaaac gacgagatcg acggcgtgaa tcaccagcat ctgcctgcta     6120

gacgggcaga gccacagcga cacacaatgc tgtgcatgtg ctgtaagtgt gaagccagga     6180

tcaagctggt ggtcgagtca agcgccgacg atctgcgcgc cttccagcag ctgttcctga     6240

atactctgtc atttgtccct tggtgtgcct cccagcagtg acgtacgtgt atgaaaaaaa     6300

ctcatcaaca gccatcatgg atgttaacga ttttgagttg catgaggact ttgcattgtc     6360

tgaagatgac tttgtcactt cagaatttct caatccggaa gaccaaatga catacctgaa     6420

tcatgccgat tataatttga attctccctt aatcagcgat gatattgatt tcctgatcaa     6480

gaaatataat catgagcaaa ttccgaaaat gtgggatgtc aagaattggg agggagtgtt     6540

agagatgttg acagcctgtc aagccagtcc aattttatct agcactatgc ataagtgggt     6600

gggaaagtgg ctcatgtctg atgatcatga cgcaagccaa ggcttcagtt ttcttcatga     6660

agtggacaaa gaagctgatc tgacgtttga ggtggtggag acattcatta gaggatgggg     6720

aggtcgagaa ttgcagtaca agaggaaaga cacatttccg gactccttta gagttgcagc     6780

ctcattgtgt caaaaattcc ttgatttgca caaactcact ctgataatga attcagtctc     6840

tgaagtcgaa cttaccaacc tagcaaagaa ttttaaagga aaaaacagga aagcaaaaag     6900

cggaaatctg ataaccagat tgagggttcc cagtttaggt cctgcttttg tgactcaggg     6960

atgggtgtac atgaagaagt tggaaatgat tatggatcgg aattttttgt tgatgttgaa     7020

agacgttatc atcgggagga tgcagacgat cctgtccatg atctcaagag atgataatct     7080

cttctccgag tctgatatct ttactgtatt aaagatatac cggatagggg ataagatatt     7140

agaaaggcaa gggacaaagg gttacgactt gatcaaaatg attgagccta tttgtaactt     7200

aaagatgatg aatctggcac gtaaatatcg tcctctcatc cctacatttc ctcattttga     7260

aaaacatatt gctgactctg ttaaggaagg atcgaaaata gacaaaggga ttgagtttat     7320

atatgatcac attatgtcaa tccctggtgt ggacttgacc ttagttattt acggatcatt     7380

tcggcactgg ggtcatcctt ttatcaacta ctatgagggc ttagagaagc tacacaagca     7440

ggttacaatg cccaagacta ttgacagaga atatgcagaa tgtcttgcta gtgatctggc     7500

aagaatcgtt cttcagcaac aattcaatga acataagaaa tggtttgttg atgtagataa     7560

agtcccacaa tcccatcctt tcaaaagcca tatgaaagag aatacttggc ctactgcagc     7620

ccaagttcag gattacggcg atcgctggca tcagctccca ctcatcaaat gcttcgaaat     7680

cccagatttg ttagatccat cgatcatcta ctcagacaaa agtcattcca tgaaccggtc     7740

tgaagtacta cgacatgtaa gacttacacc tcatgtgccc attccaagca ggaaagtatt     7800

gcagacaatg ttggagacta aggcaacaga ctggaaagag tttttaaaga aaattgacga     7860

agaggggtta gaggatgatg atcttgtcat aggactcaaa gggaaagaga gagaattaaa     7920

aattgcggga agattctttt ctttgatgtc ctggaagctc agagagtatt ttgtcatcac     7980

tgagtatttg attaagacgc actttgtccc gatgtttaaa gggttgacca tggcggatga     8040

cttgacagcg gtgataaaga agatgatgga cacatcttca ggacaaggct tagataatta     8100

tgaatccatt tgtatagcca accatattga ctatgagaag tggaacaatc atcaaagaaa     8160

agagtcgaac gggcccgtgt tcaaggtgat gggtcaattc ttgggatatc cacgtctgat     8220

tgagagaact catgaatttt ttgagaagag tctgatatat tacaatggac gaccagatct     8280

gatgcgggtt cgaggaaatt ctctagtcaa cgcctcatct ttaaatgtct gctgggaggg     8340

tcaagctggg ggattagaag gactgcgaca gaagggatgg agtattctaa atttgcttgt     8400

cattcagaga gaagcaaaaa taaggaacac cgccgtgaaa gtgctagctc aaggtgacaa     8460

tcaggtgata tgtactcagt ataaaacgaa gaaatcccgg aatgatattg agcttaaggc     8520

agctctaaca cagatggtat ctaataatga gatgattatg tctgcgatta aatcaggcac     8580

cgagaaactg ggtcttttga ttaatgatga tgagacaatg caatctgctg attacctcaa     8640

ttacgggaag gttcccattt tcagaggagt aatcagaggc cttgagacaa aaagatggtc     8700

tcgagtgacc tgtgtgacaa atgatcagat tccaacgtgt gcgaacatta tgagctctgt     8760

gtcaactaat gcattaactg tagcccattt tgccgagaat ccagtcaatg ccatcattca     8820

gtataactac tttggaacat ttgcaaggct actgctgatg atgcatgacc ccgctctgag     8880

gatctctctg tatgaagtcc aatcaaaaat tccaggactt cacagtttga catttaaata     8940

ttctatgttg tatctggatc cttcgatagg aggagtctcc ggaatgtcac tctcgagatt     9000

cctcataaga tcatttccag atccagtgac agaaagtttg gcgttctgga aatttatcca     9060

ctctcatgca agaagcgatt cattaaagga gatatgtgca gtttttggaa atcctgaaat     9120

tgcaagattt cggctaactc atgtcgataa attggtggaa gacccaacct cattgaacat     9180

agctatggga atgagtcctg ctaatctatt aaagacagag gtaaaaaaat gtctactgga     9240

atcaaggcag agcatcaaga accagattgt aagagatgct actatttacc tacaccatga     9300

ggaagacaaa cttcgtagtt tcttatggtc cataacacca ctgttccctc ggttcttgag     9360

tgaattcaaa tctgggacat tcatcggagt agcagatggc ctgatcagct tatttcagaa     9420

ctctaggact attcgaaatt cttttaaaaa gcgttatcac agggaacttg atgatttaat     9480

aatcaagagc gaagtttcct cacttatgca tttgggtaag ctacatttga ggcgaggctc     9540

agttcgtatg tggacttgct cttctactca ggctgatctt ctccgattcc ggtcatgggg     9600

aagatctgtt ataggaacca cagtccctca tcccttagag atgttaggac aacattttaa     9660

aaaggagact ccttgcagtg cttgcaacat atccggatta gactatgtat ctgtccactg     9720

tccgaatggg attcatgacg tttttgaatc acgtggtcca ctccctgcat atttgggttc     9780

taaaacatcc gaatcaactt cgatcttgca gccgtgggag agagagagta aagtaccgtt     9840

gattaagcgt gccacaaggc ttcgtgatgc aatttcatgg tttgtgtctc ccgactctaa     9900

cttggcctca actatcctta agaacataaa tgcattaaca ggagaagaat ggtcaaagaa     9960

gcagcatgga tttaaaagga cgggatcggc gttacacagg ttctccacat ccaggatgag    10020

tcatggtggt tttgcttctc agagtacggc tgccttgact agattgatgg caactactga    10080

cactatgaga gatctgggag aacagaacta tgatttcctg tttcaggcga cattattgta    10140

tgctcaaata accacaactg tagtcaggaa tggatcattt catagctgca cggaccatta    10200

ccatataacc tgcaaatctt gtctgagggc cattgatgag attaccttgg attcagcgat    10260

ggaatatagc cctccagatg tatcatcagt tttacaatct tggaggaatg gagaaggctc    10320

ttggggacat gaagtgaaac aaatataccc agttgaaggt gactggaggg gactatctcc    10380

tgttgaacaa tcttatcaag tcggacgctg tatcgggttt ctgttcggtg atctggcgta    10440

tagaaaatca tcccatgcag atgatagctc catgtttccg ttatctatac aaaacaaagt    10500

cagaggaaga ggctttttaa aagggcttat ggatgggtta atgagagcca gttgttgcca    10560

ggtgatccat cgtcgaagct tagcccatct gaagagaccg gctaatgcag tctatggagg    10620

gctgatttat ttgatagaca aattgagtgc atctgcccct tttctttcac tgacgagaca    10680

tggaccttta agggaagaat tagaaactgt tccacataag ataccgactt cttatcctac    10740

gagcaaccga gatatggggg tgatagttcg taattatttt aaatatcagt gcagactggt    10800

agaaaaaggt cggtacaaga cacattatcc tcaattgtgg cttttctcag atgtgctgtc    10860

cattgatttc ttaggacccc tgtctatatc ttcaactcta ttgggtattc tgtataaaca    10920

gacgttatct tctcgagaca aaaatgagtt gagagaactc gctaacttgt cttcattgtt    10980

gagatcagga gaaggatggg aagatatcca tgtcaaattc ttctctaagg acactttact    11040

ctgccctgaa gagatccgac atgcgtgcaa atttgggatt gctaaggaat ccgctgtttt    11100

aagctattat cctccttggt ctcaagagtc ttatggaggc atcacctcga tccccgtata    11160

tttttcgacc aggaagtatc ccaaaatttt agatgtccct cctcgggttc aaaacccatt    11220

ggtctcgggt ctacgattgg ggcaactccc tactggagca cattataaga ttaggagcat    11280

tgtaaagaac aagaaccttc gttatagaga tttccttagt tgtggggatg gatctggggg    11340

gatgaccgcg gcactattga gagaaaacag acaaagtagg ggaatcttca acagcctgtt    11400

agagttagcc ggatctctta tgagaggagc atctccagag cctccaagtg cactggagac    11460

gctcgggcaa gaacgatcta ggtgtgtgaa tggaagcaca tgttgggagt actcatctga    11520

cctaagccaa aaagagacat gggattactt cttaagattg aagagaggcc tgggtttgac    11580

cgtggactta atcaccatgg acatggaggt cagagaccct aatacaagtt tgatgataga    11640

aaagaacctc aaagtttatc tgcatcagat attagaacca actggtgtct taatatataa    11700

aacatacggg acccatattg cgacacaaac agataatatc ctgacgataa tcggtccttt    11760

ctttgagacg gttgacctag tccagtccga atacagcagc tcacaaacgt ccgaggtcta    11820

ttttgtagga cgaggcttgc gctctcatgt tgacgaaccc tgggtggact ggccatcctt    11880

aatggacaat tggagatcca tttatgcttt tcatgatcct actacagaat ttatcagagc    11940

aaaaaaagtc tgtgaaattg acagtcttat aggcattccg gctcaattca ttccagaccc    12000

atttgtaaat ctcgagacca tgctacagat agttggtgtt ccaacaggag tttcgcatgc    12060

cgcagctcta ttatcatcac aatatccaaa tcaattggtc acaacgtcaa tattttatat    12120

gacactcgtg tcttattata atgtaaacca tattcgaaga agccccaagc ctttctctcc    12180

tccgtctgat ggagtctcac agaacattgg ttcagccata gtcggactaa gtttttgggt    12240

gagtttgatg gagaatgatc tcggattata caaacaggct ctaggtgcaa taaagacgtc    12300

attccctatt agatggtcct ctgtccagac caaggatggg tttacacaag aatggagaac    12360

taaaggaaac ggaattccta aagattgtcg tctctcagac tctttggctc agataggaaa    12420

ctggatcaga gcgatggaat tggttaggaa caaaacgagg caatcaggat tttctgaaac    12480

cctatttgat caattctgcg gacttgcaga ccatcacctc aaatggcgga agttgggaaa    12540

cagaacagga attattgatt ggctaaataa tagaatttca tccattgaca aatccatctt    12600

ggtgaccaaa agtgatctgc atgacgagaa ctcatggagg gagtgaagat gtattcttcc    12660

acctctcatt gggtgatacc catatatgaa aaaaactata agtactttaa actctctttg    12720

ttttttaatg tatatctggt tttgttgttt ccgt                                12754


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope sequence

<400>  53

Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
1               5                   10                  15      


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln 
            20                  25                  


<210>  54
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E6 protein

<400>  54

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


<210>  55
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E6 protein

<400>  55

Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
1               5                   10                  15      


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
            20                  25                  30          


<210>  56
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E6 protein

<400>  56

Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
1               5                   10                  15      


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
            20                  25                  30          


<210>  57
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E6 protein

<400>  57

Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
1               5                   10                  15      


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
            20                  25                  30          


<210>  58
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E7 protein

<400>  58

Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
1               5                   10                  15      


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
            20                  25                  30  


<210>  59
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E7 protein

<400>  59

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu 
        35  


<210>  60
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E7 protein

<400>  60

Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu Pro Ala 
1               5                   10                  15      


Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys Cys Lys 
            20                  25                  30          


Cys Glu Ala 
        35  


<210>  61
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of wild-type HPV18 E7 protein

<400>  61

Arg Ile Lys Leu Val Val Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe 
1               5                   10                  15      


Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val Cys Pro Trp Cys Ala 
            20                  25                  30          


Ser Gln Gln 
        35  


