﻿                         序列表

<110>  王跃驹

<120>  植物作为宿主在表达卡那抗体中的应用

<130>  OP180790

<160>  4

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1350
<212>  DNA
<213>  Heavy chain of Canakinumab

<400>  1
atgcaagtgc aactcgttga atccggcggt ggcgtagttc agcctggccg aagcctgcgt        60
ttgtcctgtg ccgcttctgg atttacattt agcgtttatg gaatgaattg ggttaggcag       120
gcacctggga aaggacttga gtgggtagct atcatctggt acgatggcga caaccaatac       180
tacgcagatt ctgtgaaggg ccgatttacg atctcccgtg ataactctaa gaacacactg       240
tatctgcaaa tgaacggact tagggctgaa gataccgccg tctactattg cgcaagagat       300
ttaagaactg ggcccttcga ctactggggt caggggactt tagtcacggt ttcttcagcc       360
tcaacaaaag gtccaagcgt tttccctctc gctccatcct caaaatctac gagtggcggg       420
acagctgcac tgggatgctt agttaaggat tatttccctg aaccggttac agtaagttgg       480
aactctgggg ctcttacttc aggcgtacat acgttcccag cagtccttca gagctccggg       540
ttgtacagtc tgtcctcagt tgtgaccgtg ccgtcttcta gccttggtac acaaacgtat       600
atctgcaatg tcaatcacaa accgtccaac actaaggttg acaagcgagt cgagcccaaa       660
tcttgcgata agacccacac atgtcctcca tgccccgctc ccgaactctt agggggcccg       720
tccgtgttcc tgtttccacc gaagcccaag gacacactca tgatttcccg tacgccggaa       780
gttacttgcg tggttgtgga tgtctcacac gaagacccag aggttaaatt taattggtat       840
gtagatgggg tagaggtgca taatgcaaaa acgaaaccga gggaggagca gtataactct       900
acttatagag tagtaagcgt tttgacggtg ttacatcagg actggcttaa tggcaaagag       960
tataagtgta aagtaagtaa caaagcctta cctgccccca tagaaaagac tatatctaaa      1020
gctaaaggtc aacctcgtga acctcaggtc tatacgctgc ctccgtctag ggaagaaatg      1080
actaagaatc aagtttccct gacgtgcctt gttaaaggct tctatccaag cgacatcgct      1140
gtcgagtggg aaagtaatgg gcaacctgag aacaactaca aaacgactcc accggtttta      1200
gactctgacg gctccttctt tttgtacagt aagttaacgg tagacaagtc taggtggcag      1260
cagggaaacg tcttttcatg ctctgtcatg catgaagccc tgcacaatca ttatacacag      1320
aagagtttaa gtctcagtcc gggtaaataa                                       1350

<210>  2
<211>  448
<212>  PRT
<213>  Heavy chain of Canakinumab

<400>  2
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ile Ile Trp Tyr Asp Gly Asp Asn Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Leu Arg Thr Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             

<210>  3
<211>  648
<212>  DNA
<213>  Light chain of Canakinumab

<400>  3
atggagatag tattgacaca atcccctgat ttccaatctg taaccccaaa ggaaaaagtc        60
accatcacat gccgtgcttc ccagagcatt ggttcctcac tccattggta tcaacaaaag       120
cccgaccagt ctcccaagct gctgatcaaa tatgcttctc aaagtttttc aggtgtgcca       180
tccaggttct ctgggtctgg gagtggcacg gatttcactc ttactataaa cagtcttgaa       240
gctgaggatg ctgccgccta ctactgtcac caaagcagca gcctgccttt tacgtttggc       300
cccggaacaa aagtggatat taagagaacc gtcgccgccc catcagtatt tatctttcct       360
cccagcgatg agcagttaaa atctggtacg gcaagcgtgg tctgcctctt aaacaatttt       420
tacccacgtg aggctaaagt tcaatggaaa gtagacaacg ctcttcagtc tggaaatagc       480
caggaaagcg tgactgagca agatagcaag gattccacat acagtctttc atccacactg       540
acattatcaa aggccgacta tgaaaaacat aaagtttatg cttgcgaagt cacacatcag       600
ggtctctcct cacccgtgac caaaagtttc aataggggtg aatgttaa                    648

<210>  4
<211>  214
<212>  PRT
<213>  Light chain of Canakinumab

<400>  4
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

