                         SEQUENCE LISTING

<110>  ISTITUTO ORTOPEDICO RIZZOLI
       ISTITUTO SUPERIORE DI SANITA'
 
<120>  Exosomes and uses thereof

<130>  61.I3257.12.WO.26

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-let-7c-5p

<400>  1
ugagguagua gguuguaugg uu                                                22


<210>  2
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-let-7g-5p

<400>  2
ugagguagua guuuguacag uu                                                22


<210>  3
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-1182

<400>  3
gggacuuguc acugccuguc uccucccucu ccagcagcga cuggauucug gaguccaucu       60

agagggucuu gggagggaug ugacuguugg gaagccc                                97


<210>  4
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-1249-5p

<400>  4
aggagggagg agaugggcca aguu                                              24


<210>  5
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-125a-3p

<400>  5
acaggugagg uucuugggag cc                                                22


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-1273g-3p

<400>  6
accacugcac uccagccuga g                                                 21


<210>  7
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-1295b-3p

<400>  7
aauaggccac ggaucugggc aa                                                22


<210>  8
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-134-5p

<400>  8
ugugacuggu ugaccagagg gg                                                22


<210>  9
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-1343-5p

<400>  9
uggggagcgg cccccgggug gg                                                22


<210>  10
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-15b-5p

<400>  10
uagcagcaca ucaugguuua ca                                                22


<210>  11
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-186-3p

<400>  11
gcccaaaggu gaauuuuuug gg                                                22


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-1910-5p

<400>  12
ccaguccugu gccugccgcc u                                                 21


<210>  13
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-1911-5p

<400>  13
ugaguaccgc caugucuguu ggg                                               23


<210>  14
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-196a-5p

<400>  14
uagguaguuu cauguuguug gg                                                22


<210>  15
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-196b-5p

<400>  15
uagguaguuu ccuguuguug gg                                                22


<210>  16
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-199a-3p

<400>  16
acaguagucu gcacauuggu ua                                                22


<210>  17
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-214-3p

<400>  17
acagcaggca cagacaggca gu                                                22


<210>  18
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-29a-3p

<400>  18
uagcaccauc ugaaaucggu ua                                                22


<210>  19
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-345-3p

<400>  19
gcccugaacg aggggucugg ag                                                22


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-3617-5p

<400>  20
aaagacauag uugcaagaug gg                                                22


<210>  21
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-3682-3p

<400>  21
ugaugauaca gguggaggua g                                                 21


<210>  22
<211>  93
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-3917

<400>  22
ggcgcuuuug ugcgcgcccg ggucuguugg ugcucagagu guggucaggc ggcucggacu       60

gagcaggugg gugcggggcu cggaggaggc ggc                                    93


<210>  23
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-3923

<400>  23
gguagaguga gcucuaaucc aauauuacua gcuucuuuau aagaagagga aacuaguaau       60

guuggauuag ggcucacucu acu                                               83


<210>  24
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-423-5p

<400>  24
ugaggggcag agagcgagac uuu                                               23


<210>  25
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-4271

<400>  25
aaaucucucu ccauaucuuu ccugcagccc ccaggugggg gggaagaaaa gguggggaau       60

uagauuc                                                                 67


<210>  26
<211>  76
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-4294

<400>  26
ccgaugccuc gggagucuac agcagggcca ugucugugag ggcccaaggg ugcauguguc       60

ucccagguuu cggugc                                                       76


<210>  27
<211>  73
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-4429

<400>  27
agggagaaaa gcugggcuga gaggcgacug gugucuaauu uguuugucuc uccaacucag       60

acugccuggc cca                                                          73


<210>  28
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-4443

<400>  28
gguggggguu ggaggcgugg guuuuagaac cuaucccuuu cuagcccuga gca              53


<210>  29
<211>  69
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-4499

<400>  29
aagacugaga ggagggaacu ggugaguugu acauagaaau gcuuucuaac uccuugucuc       60

agucuguuu                                                               69


<210>  30
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-4640-5p

<400>  30
ugggccaggg agcagcuggu ggg                                               23


<210>  31
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-4646-5p

<400>  31
acugggaaga ggagcugagg ga                                                22


<210>  32
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-4688

<400>  32
gucuacuccc agggugccaa gcuguuucgu guucccuccc uaggggaucc cagguagggg       60

cagcagagga ccugggccug gac                                               83


<210>  33
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-486-5p

<400>  33
uccuguacug agcugccccg ag                                                22


<210>  34
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-5003-3p

<400>  34
uacuuuucua gguuguuggg g                                                 21


<210>  35
<211>  79
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-5685

<400>  35
cucuacauca cagcccagca guuaucacgg gccccucccc ucaaugggcc cgugauaacu       60

gcagggcugu gauguagag                                                    79


<210>  36
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-6073

<400>  36
uagauguugg uccaaacuga aaguugauga gucacugugc cucucggggu agugaguuau       60

cagcuacagu gagagagcag uguuuggcc                                         89


<210>  37
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-6076

<400>  37
agcaugacag aggagaggug gagguaggcg agaguaauau aauuucucca ggagaacauc       60

ugagagggga aguugcuuuc cugcccuggc ccuuucaccc uccugaguuu ggg             113


<210>  38
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-6083

<400>  38
guaaaaagag uccagagucu gggaaggugg aaagggagca ggagcaucgu cuuuaagagg       60

gucagguacc uuugcucuua uaucagaggc ugugggcuuc cuacag                     106


<210>  39
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-623

<400>  39
guacacagua gaagcauccc uugcaggggc uguuggguug cauccuaagc ugugcuggag       60

cuucccgaug uacucuguag augucuuugc accuucug                               98


<210>  40
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-638

<400>  40
gugagcgggc gcggcaggga ucgcgggcgg guggcggccu agggcgcgga gggcggaccg       60

ggaauggcgc gccgugcgcc gccggcguaa cugcggcgcu                            100


<210>  41
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-642b-3p

<400>  41
agacacauuu ggagagggac cc                                                22


<210>  42
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6510-5p

<400>  42
cagcagggga gagagaggag uc                                                22


<210>  43
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-652-5p

<400>  43
caacccuagg agagggugcc auuca                                             25


<210>  44
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6728-5p

<400>  44
uugggauggu aggaccagag ggg                                               23


<210>  45
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6730-5p

<400>  45
agaaaggugg agggguuguc aga                                               23


<210>  46
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6738-5p

<400>  46
cgagggguag aagagcacag ggg                                               23


<210>  47
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6740-5p

<400>  47
aguuugggau ggagagagga ga                                                22


<210>  48
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6741-5p

<400>  48
gugggugcug gugggagccg ug                                                22


<210>  49
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6793-5p

<400>  49
uguggguucu ggguuggggu ga                                                22


<210>  50
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6820-5p

<400>  50
ugcggcagag cugggguca                                                    19


<210>  51
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-6870-5p

<400>  51
ugggggagau ggggguuga                                                    19


<210>  52
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-708-5p

<400>  52
aaggagcuua caaucuagcu ggg                                               23


<210>  53
<211>  70
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-718

<400>  53
ggccgcggcg cgcaagaugg cggcgggccc gggcaccgcc ccuuccgccc cgccgggcgu       60

cgcacgaggc                                                              70


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-miR-7847-3p

<400>  54
cguggaggac gaggaggagg c                                                 21


<210>  55
<211>  68
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-7975

<400>  55
gugcaaagag caggaggaca ggggauuuau cucccaaggg agguccccug auccuaguca       60

cggcacca                                                                68


<210>  56
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  hsa-mir-8087

<400>  56
ucuaagaagu gaagacuucu uggauuacag gggcccuacu uuaagggccc uuucaguugg       60

aaguuuuccu uucugccu                                                     78


<210>  57
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenza cDNA CD99 type I

<400>  57
atggcccgcg gggctgcgct ggcgctgctg ctcttcggcc tgctgggtgt tctggtcgcc       60

gccccggatg gtggtttcga tttatccgat gcccttcctg acaatgaaaa caagaaaccc      120

actgcaatcc ccaagaaacc cagtgctggg gatgactttg acttaggaga tgctgttgtt      180

gatggagaaa atgacgaccc acgaccaccg aacccaccca aaccgatgcc aaatccaaac      240

cccaaccacc ctagttcctc cggtagcttt tcagatgctg accttgcgga tggcgtttca      300

ggtggagaag gaaaaggagg cagtgatggt ggaggcagcc acaggaaaga aggggaagag      360

gccgacgccc caggcgtgat ccccgggatt gtgggggctg tcgtggtcgc cgtggctgga      420

gccatctcta gcttcattgc ttaccagaaa aagaagctat gcttcaaaga aaatgcagaa      480

caaggggagg tggacatgga gagccaccgg aatgccaacg cagagccagc tgttcagcgt      540

actcttttag agaaatag                                                    558


<210>  58
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequenza Proteina CD99 type I

<400>  58

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Asp Asn Glu Asn Lys Lys Pro Thr Ala Ile Pro Lys Lys Pro Ser 
        35                  40                  45              


Ala Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
    50                  55                  60                  


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
65                  70                  75                  80  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
                85                  90                  95      


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
            100                 105                 110         


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
        115                 120                 125             


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
    130                 135                 140                 


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
145                 150                 155                 160 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
                165                 170                 175     


Ala Val Gln Arg Thr Leu Leu Glu Lys 
            180                 185 


<210>  59
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequenza cDNA CD99 type II

<400>  59
atggcccgcg gggctgccct ggcgctgctg ctcttcggcc tgctgggtgt tctggtcgcc       60

gccccggatg gtggtttcga tttatctgat gcccttcctg acaatgaaaa caagaaaccc      120

actgcaatcc ccaagaaacc cagtgctggg gatgactttg acttaggaga tgctgttgtt      180

gatggagaaa atgacgaccc acgaccaccg aacccaccca aaccgatgcc aaatccaaac      240

cccaaccacc ctagttcctc cggtagcttt tcagatgctg accttgcgga tggcgtttca      300

ggtggagaag gaaaaggagg cagtgatggt ggaggcagcc acaggaaaga aggggaagag      360

gccgacgccc caggcgtgat ccccgggatt gtgggggctg tcgtggtcgc cgtggctgga      420

gccatctcta gcttcattgc ttaccagaaa aagaagctat gcttcaaaga aaatgatggc      480

tgaagaccta gggaacaagg ggaggtggac atggagagcc accggaatgc caacgcagag      540

ccagctgttc agcgtactct tttagagaaa tag                                   573


<210>  60
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteina CD99 type II

<400>  60

Met Ala Arg Gly Ala Ala Leu Ala Leu Leu Leu Phe Gly Leu Leu Gly 
1               5                   10                  15      


Val Leu Val Ala Ala Pro Asp Gly Gly Phe Asp Leu Ser Asp Ala Leu 
            20                  25                  30          


Pro Gly Asp Asp Phe Asp Leu Gly Asp Ala Val Val Asp Gly Glu Asn 
        35                  40                  45              


Asp Asp Pro Arg Pro Pro Asn Pro Pro Lys Pro Met Pro Asn Pro Asn 
    50                  55                  60                  


Pro Asn His Pro Ser Ser Ser Gly Ser Phe Ser Asp Ala Asp Leu Ala 
65                  70                  75                  80  


Asp Gly Val Ser Gly Gly Glu Gly Lys Gly Gly Ser Asp Gly Gly Gly 
                85                  90                  95      


Ser His Arg Lys Glu Gly Glu Glu Ala Asp Ala Pro Gly Val Ile Pro 
            100                 105                 110         


Gly Ile Val Gly Ala Val Val Val Ala Val Ala Gly Ala Ile Ser Ser 
        115                 120                 125             


Phe Ile Ala Tyr Gln Lys Lys Lys Leu Cys Phe Lys Glu Asn Ala Glu 
    130                 135                 140                 


Gln Gly Glu Val Asp Met Glu Ser His Arg Asn Ala Asn Ala Glu Pro 
145                 150                 155                 160 


Ala Val Gln Arg Thr Leu Leu Glu Lys 
                165                 


<210>  61
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  molecola short hairpin (sh) RNA specifica per il gene MIC2/CD99

<400>  61
gatccggctg gccattatta agtcttcaag agagacttaa taatggccag cctttttgga       60

aa                                                                      62


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'UTR del gene CD99 target di SEQ ID NO: 61

<400>  62
ggctggccat tattaagtc                                                    19


<210>  63
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miRNA 328-5p

<400>  63
gggggggcag gaggggcuca ggg                                               23


