<110>    HUB Biotech Co., Ltd.

<120>    Recombinant Cell and Method for Production of Endogenous
         Polypeptide

<130>    DPP20182127KR

<150>    KR10-2017-0143973
<151>    2017-10-31

<160>    21

<170>    KopatentIn 3.0

<210>    1
<211>    12
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (Essential part of crRNA)


<400>    1
guuuuagagc ua                                                             12


<210>    2
<211>    10
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (3'-terminal part of crRNA)


<400>    2
ugcuguuuug                                                                10


<210>    3
<211>    60
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (Essential part of tracrRNA)


<400>    3
uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc gagucggugc         60

                                                                          60


<210>    4
<211>    1368
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic (Cas9 from Streptococcus pyogenes)


<400>    4
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val
  1               5                  10                  15 

Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe
             20                  25                  30 

Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile
         35                  40                  45 

Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu
     50                  55                  60 

Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys
 65                  70                  75                  80 

Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser
                 85                  90                  95 

Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys
            100                 105                 110 

His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr
        115                 120                 125 

His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp
    130                 135                 140 

Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His
145                 150                 155                 160 

Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro
                165                 170                 175 

Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr
            180                 185                 190 

Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala
        195                 200                 205 

Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn
    210                 215                 220 

Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn
225                 230                 235                 240 

Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe
                245                 250                 255 

Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp
            260                 265                 270 

Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp
        275                 280                 285 

Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp
    290                 295                 300 

Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser
305                 310                 315                 320 

Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys
                325                 330                 335 

Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe
            340                 345                 350 

Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser
        355                 360                 365 

Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp
    370                 375                 380 

Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg
385                 390                 395                 400 

Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu
                405                 410                 415 

Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe
            420                 425                 430 

Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile
        435                 440                 445 

Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp
    450                 455                 460 

Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu
465                 470                 475                 480 

Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr
                485                 490                 495 

Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser
            500                 505                 510 

Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys
        515                 520                 525 

Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln
    530                 535                 540 

Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr
545                 550                 555                 560 

Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp
                565                 570                 575 

Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly
            580                 585                 590 

Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp
        595                 600                 605 

Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr
    610                 615                 620 

Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala
625                 630                 635                 640 

His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr
                645                 650                 655 

Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp
            660                 665                 670 

Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe
        675                 680                 685 

Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe
    690                 695                 700 

Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu
705                 710                 715                 720 

His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly
                725                 730                 735 

Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly
            740                 745                 750 

Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln
        755                 760                 765 

Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile
    770                 775                 780 

Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro
785                 790                 795                 800 

Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu
                805                 810                 815 

Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg
            820                 825                 830 

Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys
        835                 840                 845 

Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg
    850                 855                 860 

Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys
865                 870                 875                 880 

Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys
                885                 890                 895 

Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp
            900                 905                 910 

Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr
        915                 920                 925 

Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp
    930                 935                 940 

Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser
945                 950                 955                 960 

Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg
                965                 970                 975 

Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val
            980                 985                 990 

Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe
        995                1000                1005 

Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys
   1010                1015                1020 

Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser
1025               1030                1035                1040 

Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu
               1045                1050                1055 

Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile
           1060                1065                1070 

Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser
       1075                1080                1085 

Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly
   1090                1095                1100 

Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile
1105               1110                1115                1120 

Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser
               1125                1130                1135 

Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly
           1140                1145                1150 

Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile
       1155                1160                1165 

Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala
   1170                1175                1180 

Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys
1185               1190                1195                1200 

Tyr Ser Leu Phe Glu Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser
               1205                1210                1215 

Ala Gly Glu Leu Gln Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr
           1220                1225                1230 

Val Asn Phe Leu Tyr Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser
       1235                1240                1245 

Pro Glu Asp Asn Glu Gln Lys Gln Leu Phe Val Glu Gln His Lys His
   1250                1255                1260 

Tyr Leu Asp Glu Ile Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val
1265               1270                1275                1280 

Ile Leu Ala Asp Ala Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys
               1285                1290                1295 

His Arg Asp Lys Pro Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu
           1300                1305                1310 

Phe Thr Leu Thr Asn Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp
       1315                1320                1325 

Thr Thr Ile Asp Arg Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp
   1330                1335                1340 

Ala Thr Leu Ile His Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile
1345               1350                1355                1360 

Asp Leu Ser Gln Leu Gly Gly Asp
               1365            


<210>    5
<211>    14
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (General formula of SpCas9 crRNA)


<220>
<221>    misc_feature
<222>    (1)
<223>    n is targeting sequence comprising 18-22 or 20 nucleotides


<220>
<221>    misc_feature
<222>    (14)
<223>    n comprises 8-12 or 10 nucleotides, each of which is A, U, C, or
         G


<400>    5
nguuuuagag cuan                                                           14


<210>    6
<211>    61
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (General formula of SpCas9 tracrRNA)


<220>
<221>    misc_feature
<222>    (1)
<223>    n comprises 6-20 or 8-19 nucleotides, each of which is A, U, C,
         or G


<400>    6
nuagcaaguu aaaauaaggc uaguccguua ucaacuugaa aaaguggcac cgagucggug         60

c                                                                         61


<210>    7
<211>    80
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (General formula of SpCas9 sgRNA)


<220>
<221>    misc_feature
<222>    (1)
<223>    n is targeting sequence comprising 18-22 or 20 nucleotides


<220>
<221>    misc_feature
<222>    (14)
<223>    n is a linker comprising 3-5 or 4 nucleotides


<400>    7
nguuucaguu gcunaugcuc uguaaucauu uaaaaguauu uugaacggac cucuguuuga         60

cacgucugaa uaacuaaaaa                                                     80


<210>    8
<211>    22
<212>    RNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (General formula of Cpf1 crRNA)


<220>
<221>    misc_feature
<222>    (1)
<223>    n is absent, U, A, or G


<220>
<221>    misc_feature
<222>    (2)
<223>    n is A, or G


<220>
<221>    misc_feature
<222>    (5)
<223>    n is U, A, or C


<220>
<221>    misc_feature
<222>    (12)
<223>    n is absent, G, C, or A


<220>
<221>    misc_feature
<222>    (13)
<223>    n is absent, A, U, C, or G


<220>
<221>    misc_feature
<222>    (14)
<223>    n is U, G, or C


<220>
<221>    misc_feature
<222>    (15)
<223>    n is U or G


<400>    8
nnaunucuac unnnnguaga un                                                  22


<210>    9
<211>    1758
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (HygR-sfGFP)


<400>    9
atgaaaaagc ctgaactcac cgcgacgtct gtcgagaagt ttctgatcga aaagttcgac         60

agcgtctccg acctgatgca gctctcggag ggcgaagaat ctcgtgcttt cagcttcgat        120

gtaggagggc gtggatatgt cctgcgggta aatagctgcg ccgatggttt ctacaaagat        180

cgttatgttt atcggcactt tgcatcggcc gcgctcccga ttccggaagt gcttgacatt        240

ggggaattca gcgagagcct gacctattgc atctcccgcc gtgcacaggg tgtcacgttg        300

caagacctgc ctgaaaccga actgcccgct gttctgcagc cggtcgcgga ggccatggat        360

gcgatcgctg cggccgatct tagccagacg agcgggttcg gcccattcgg accgcaagga        420

atcggtcaat acactacatg gcgtgatttc atatgcgcga ttgctgatcc ccatgtgtat        480

cactggcaaa ctgtgatgga cgacaccgtc agtgcgtccg tcgcgcaggc tctcgatgag        540

ctgatgcttt gggccgagga ctgccccgaa gtccggcacc tcgtgcacgc ggatttcggc        600

tccaacaatg tcctgacgga caatggccgc ataacagcgg tcattgactg gagcgaggcg        660

atgttcgggg attcccaata cgaggtcgcc aacatcttct tctggaggcc gtggttggct        720

tgtatggagc agcagacgcg ctacttcgag cggaggcatc cggagcttgc aggatcgccg        780

cggctccggg cgtatatgct ccgcattggt cttgaccaac tctatcagag cttggttgac        840

ggcaatttcg atgatgcagc ttgggcgcag ggtcgatgcg acgcaatcgt ccgatccgga        900

gccgggactg tcgggcgtac acaaatcgcc cgcagaagcg cggccgtctg gaccgatggc        960

tgtgtagaag tactcgccga tagtggaaac cgacgcccca gcactcgtcc ggatcgggag       1020

atgggggaga ctagaatgtc taagggcgag gaactgttca ccggcgtggt gcccatcctg       1080

gtggaactgg atggcgacgt gaacggccac aagttctctg tgcggggaga gggcgaaggc       1140

gacgccacaa atggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg       1200

ccttggccta ccctcgtgac cacactgacc tacggcgtgc agtgcttcag cagatacccc       1260

gaccacatga agcggcacga tttcttcaag agcgccatgc ccgagggcta tgtgcaggaa       1320

cggaccatca gcttcaagga cgacggcacc tacaagacca gagccgaagt gaagttcgag       1380

ggcgacaccc tcgtgaaccg gatcgagctg aagggcatcg acttcaaaga ggacggcaac       1440

atcctgggcc acaagctgga gtacaacttc aacagccaca acgtgtacat caccgccgac       1500

aagcagaaga acggcatcaa ggccaacttc aagatccggc acaacgtgga agatggcagc       1560

gtgcagctgg ccgaccacta ccagcagaac acccccatcg gagatggccc cgtgctgctg       1620

cccgacaacc actacctgag cacccagagc gtgctgagca aggaccccaa cgagaagcgg       1680

gaccacatgg tgctgctgga atttgtgacc gccgctggca tcacccacgg catggacgag       1740

ctgtacaagt ctagttga                                                     1758


<210>    10
<211>    588
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (CMV(Cytomegalovirus) promoter)


<400>    10
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg         60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt        120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca        180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc        240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta        300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac        360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg        420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg        480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt        540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagat                     588


<210>    11
<211>    133
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (SV40 intron)


<400>    11
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga         60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc        120

tttctctcca cag                                                           133


<210>    12
<211>    75
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (signal peptide coding sequence)


<400>    12
atggagcgca gtggctgggc ccggcagact tttctcctag cgctgttgct gggggcgacg         60

ctgagagcgc gcgcg                                                          75


<210>    13
<211>    24
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (FLAG tag)


<400>    13
gattacaagg atgacgatga caag                                                24


<210>    14
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (RELN_sg1)


<400>    14
gcgctaggag gaaagtctgc cgg                                                 23


<210>    15
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (RELN_sg2)


<400>    15
tttcctccta gcgctgttgc tgg                                                 23


<210>    16
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (RELN_sg3)


<400>    16
ttcctcctag cgctgttgct ggg                                                 23


<210>    17
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (RELN_sg4)


<400>    17
tcctcctagc gctgttgctg ggg                                                 23


<210>    18
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (RELN_sg5)


<400>    18
cccccagcaa cagcgctagg agg                                                 23


<210>    19
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (RELN_sg6)


<400>    19
tgttgctggg ggcgacgctg agg                                                 23


<210>    20
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (RELN_sg7)


<400>    20
gttgctgggg gcgacgctga ggg                                                 23


<210>    21
<211>    9172
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic (full sequence of pAAY-hygro-sfGFP plasmid)


<400>    21
gagacggtca cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg         60

tcagcgggtg ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta        120

ctgagagtgc accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc        180

atcaggcgcc attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc        240

tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta        300

acgccagggt tttcccagtc acgacgttgt aaaacgacgg ccagtgggat accccgaaga        360

gtgagtttgc caagcagtca ccccacagtt ggaggagaat ccacccaaaa ggcagcctgg        420

tagacagggc tggggtggcc tctcgtgggg tccaggccaa gtaggtggcc tggggcctct        480

gggggatgca ggggaagggg gatgcagggg aacggggatg caggggaacg gggctcagtc        540

tgaagagcag agccaggaac ccctgtaggg aaggggcagg agagccaggg gcatgagatg        600

gtggacgagg aagggggaca gggaagcctg agcgcctctc ctgggcttgc caaggactca        660

aacccagaag cccagagcag ggccttaggg aagcgggacc ctgctctggg cggaggaata        720

tgtcccagat agcactgggg actctttaag gaaagaagga tggagaaaga gaaagggagt        780

agaggcggcc acgacctggt gaacacctag gacgcaccat tctcacaaag ggagttttcc        840

acacggacac ccccctcctc accacagccc tgccaggacg gggctggcta ctggccttat        900

ctcacaggta aaactgacgc acggaggaac aatataaatt ggggactaga aaggtgaaga        960

gccaaagtta gaactcagga ccaacttatt ctgattttgt ttttccaaac tgcttctcct       1020

cttgggaagt gtaaggaagc tgcagcacca ggatcagtga aacgcaccag acagccgcgt       1080

cagagcagct caggttctgg gagagggtag cgcagggtgg ccactgagaa ccgggcaggt       1140

cacgaattcg agctcggtac ccggggatcc ttcgggggtg tttggcagcc acagacgccc       1200

ggtgttcgtg tcgcgccagt acatgcggtc catgcccagg ccatccaaaa accatgggtc       1260

tgtctgctca gtccagtcgt ggacctgacc ccacgcaacg cccaaaataa taacccccac       1320

gaaccataaa ccattcccca tgggggaccc cgtccctaac ccacggggcc agtggctatg       1380

gcagggcctg ccgccccgac gttggctgcg agccctgggc cttcacccga acttgggggg       1440

tggggtgggg aaaaggaaga aacgcgggcg tattggcccc aatggggtct cggtggggta       1500

tcgacagagt gccagccctg ggaccgaacc ccgcgtttat gaacaaacga cccaacaccc       1560

gtgcgtttta ttctgtcttt ttattgccgt catagcgcgg gttccttccg gtattgtctc       1620

cttccgtgtt tcaactagac ttgtacagct cgtccatgcc gtgggtgatg ccagcggcgg       1680

tcacaaattc cagcagcacc atgtggtccc gcttctcgtt ggggtccttg ctcagcacgc       1740

tctgggtgct caggtagtgg ttgtcgggca gcagcacggg gccatctccg atgggggtgt       1800

tctgctggta gtggtcggcc agctgcacgc tgccatcttc cacgttgtgc cggatcttga       1860

agttggcctt gatgccgttc ttctgcttgt cggcggtgat gtacacgttg tggctgttga       1920

agttgtactc cagcttgtgg cccaggatgt tgccgtcctc tttgaagtcg atgcccttca       1980

gctcgatccg gttcacgagg gtgtcgccct cgaacttcac ttcggctctg gtcttgtagg       2040

tgccgtcgtc cttgaagctg atggtccgtt cctgcacata gccctcgggc atggcgctct       2100

tgaagaaatc gtgccgcttc atgtggtcgg ggtatctgct gaagcactgc acgccgtagg       2160

tcagtgtggt cacgagggta ggccaaggca cgggcagctt gccggtggtg cagatgaact       2220

tcagggtcag cttgccattt gtggcgtcgc cttcgccctc tccccgcaca gagaacttgt       2280

ggccgttcac gtcgccatcc agttccacca ggatgggcac cacgccggtg aacagttcct       2340

cgcccttaga cattctagtc tcccccatct cccgatccgg acgagtgctg gggcgtcggt       2400

ttccactatc ggcgagtact tctacacagc catcggtcca gacggccgcg cttctgcggg       2460

cgatttgtgt acgcccgaca gtcccggctc cggatcggac gattgcgtcg catcgaccct       2520

gcgcccaagc tgcatcatcg aaattgccgt caaccaagct ctgatagagt tggtcaagac       2580

caatgcggag catatacgcc cggagccgcg gcgatcctgc aagctccgga tgcctccgct       2640

cgaagtagcg cgtctgctgc tccatacaag ccaaccacgg cctccagaag aagatgttgg       2700

cgacctcgta ttgggaatcc ccgaacatcg cctcgctcca gtcaatgacc gctgttatgc       2760

ggccattgtc cgtcaggaca ttgttggagc cgaaatccgc gtgcacgagg tgccggactt       2820

cggggcagtc ctcggcccaa agcatcagct catcgagagc ctgcgcgacg gacgcactga       2880

cggtgtcgtc catcacagtt tgccagtgat acacatgggg atcagcaatc gcgcatatga       2940

aatcacgcca tgtagtgtat tgaccgattc cttgcggtcc gaatgggccg aacccgctcg       3000

tctggctaag atcggccgca gcgatcgcat ccatggcctc cgcgaccggc tgcagaacag       3060

cgggcagttc ggtttcaggc aggtcttgca acgtgacacc ctgtgcacgg cgggagatgc       3120

aataggtcag gctctcgctg aattccccaa tgtcaagcac ttccggaatc gggagcgcgg       3180

ccgatgcaaa gtgccgataa acataacgat ctttgtagaa accatcggcg cagctattta       3240

cccgcaggac atatccacgc cctcctacat cgaagctgaa agcacgagat tcttcgccct       3300

ccgagagctg catcaggtcg gagacgctgt cgaacttttc gatcagaaac ttctcgacag       3360

acgtcgcggt gagttcaggc tttttcatat ctcattgccc cccgggatct gcggcacgct       3420

gttgacgctg ttaagcgggt cgctgcaggg tcgctcggtg ttcgaggcca cacgcgtcac       3480

cttaatatgc gaagtggacc tcggaccgcg ccgccccgac tgcatctgcg tgttcgaatt       3540

cgccaatgac aagacgctgg gcggggtttg tgtcatcata gaactaaaga catgcaaata       3600

tatttcttcc ggggatgcat tagttattaa tagtaatcaa ttacggggtc attagttcat       3660

agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg       3720

cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata       3780

gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta       3840

catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc       3900

gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca gtacatctac       3960

gtattagtca tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga       4020

tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg       4080

ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg       4140

caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctgg tttagtgaac       4200

cgtcagatcg tttaaacaag ttggtcgtga ggcactgggc aggtaagtat caaggttaca       4260

agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt       4320

ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc cacaggtgtc       4380

cagggtaccc gatcgggatc caccggtcgt ctcgccgggg cagggggcga attcgtcgac       4440

ctcgaggccg ccatggcagt gagcaagggc gaggagctgt tcaccggggt ggtgcccatc       4500

ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg cgagggcgag       4560

ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg caagctgccc       4620

gtgccctggc ccaccctcgt gaccaccttc ggctacggcc tgcagtgctt cgcccgctac       4680

cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag       4740

gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc       4800

gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc       4860

aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta tatcatggcc       4920

gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat cgaggacggc       4980

agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg ccccgtgctg       5040

ctgcccgaca accactacct gagctaccag tccgccctga gcaaagaccc caacgagaag       5100

cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct cggcatggac       5160

gagctgtaca aggctgcaca ccatcaccat caccatcacc atcaccatta ggcggccgcg       5220

gctagcagcg gccgcacaga gacatctcag gtagcaccag catagaatca acctctggat       5280

tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt tacgctatgt       5340

ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc tttcattttc       5400

tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc cgttgtcagg       5460

caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg gggcattgcc       5520

accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc cacggcggaa       5580

ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg cactgacaat       5640

tccgtggtgt tgtcggggaa gctgacgtcc tttccatggc tgctcgcctg tgttgccacc       5700

tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc agcggacctt       5760

ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgaga tctgcctcga       5820

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       5880

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc       5940

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt       6000

gggaagacaa tagcaggcat gctggggatt aagggcgcga ttaggatctt cctagagcat       6060

ggctacgtag ataagtagca tggcgggttc tagagtcgac ctgcaggcat gcaagcttga       6120

ggttctggca aggagagaga tggctccagg aaatgggggt gtgtcaccag ataaggaatc       6180

tgcctaacag gaggtggggg ttagacccaa tatcaggaga ctaggaagga ggaggcctaa       6240

ggatggggct tttctgtcac caatcctgtc cctagtggcc ccactgtggg gtggagggga       6300

cagataaaag tacccagaac cagagccaca ttaaccggcc ctgggaatat aaggtggtcc       6360

cagctcgggg acacaggatc cctggaggca gcaaacatgc tgtcctgaag tggacatagg       6420

ggcccgggtt ggaggaagaa gactagctga gctctcggac ccctggaaga tgccatgaca       6480

gggggctgga agagctagca cagactagag aggtaagggg ggtaggggag ctgcccaaat       6540

gaaaggagtg agaggtgacc cgaatccaca ggagaacggg gtgtccaggc aaagaaagca       6600

agaggatgga gaggtggcta aagccaggga gacggggtac tttggggttg tccagaaaaa       6660

cggtgatgat gcaggcctac aagaagggga ggcgggacgc aagggagaca tccgtcggag       6720

aaggccatcc taagaaacga gagatggcac aggccccaga aggagaagga aaagggaacc       6780

cagcgagtga agacggcatg gggttgggtg agggaggaga gatgcccgga gaggacccag       6840

acacggggag gatccgctca gaggacatca cgtggtgcag cgccgagaag gaagtgctcc       6900

ggaaagagca tccttgggca gcaacacagc agagagcagg cgtaatcatg gtcatagctg       6960

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata       7020

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca       7080

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc       7140

gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg       7200

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta       7260

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc       7320

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag       7380

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac       7440

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc       7500

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt       7560

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc       7620

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga       7680

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta       7740

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta       7800

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga       7860

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg       7920

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag       7980

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc       8040

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact       8100

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt       8160

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta       8220

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta       8280

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc       8340

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat       8400

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt       8460

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg       8520

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca       8580

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta       8640

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg       8700

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact       8760

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg       8820

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt       8880

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga       8940

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc       9000

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa       9060

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt       9120

attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg tc               9172
