﻿                         SEQUENCE LISTING

<110>  同济大学苏州研究院
       房健民
 
<120>  c-MET激动型抗体及其用途

<130>  OP180646

<140>  PCT/CN2018/112874
<141>  2018-10-31

<150>  CN 201711116927.1
<151>  2017-11-13

<160>  14    

<170>  PatentIn version 3.2

<210>  1
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Artifical sequence


<220>
<221>  primer
<222>  (1)..(44)

<400>  1
tataccggtc gccaccatga aggcccccgc tgtgcttgca cctg                      44


<210>  2
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Artifical sequence


<220>
<221>  primer
<222>  (1)..(56)

<400>  2
cgcgtcgacc tagtgatggt gatgatggtg tgtgaaattc tgatctggtt gacata         56


<210>  3
<211>  2796
<212>  DNA
<213>  Homo sapiens


<220>
<221>  gene
<222>  (1)..(2796)

<400>  3
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag     60

aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag    120

tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat    180

cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag    240

gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac    300

tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta    360

gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc    420

tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc    480

atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg    540

ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc    600

ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag    660

gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag    720

ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac    780

ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg    840

ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc    900

acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg    960

tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac   1020

attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct   1080

gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa   1140

aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg   1200

acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt   1260

accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca   1320

tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt   1380

cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc   1440

ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc   1500

tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc   1560

agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg   1620

tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc   1680

tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg   1740

ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa   1800

actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat   1860

acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt   1920

tcaaatggcc acgggacaac acaatacagt acattctcct atgtggatcc tgtaataaca   1980

agtatttcgc cgaaatacgg tcctatggct ggtggcactt tacttacttt aactggaaat   2040

tacctaaaca gtgggaattc tagacacatt tcaattggtg gaaaaacatg tactttaaaa   2100

agtgtgtcaa acagtattct tgaatgttat accccagccc aaaccatttc aactgagttt   2160

gctgttaaat tgaaaattga cttagccaac cgagagacaa gcatcttcag ttaccgtgaa   2220

gatcccattg tctatgaaat tcatccaacc aaatctttta ttagtggtgg gagcacaata   2280

acaggtgttg ggaaaaacct gaattcagtt agtgtcccga gaatggtcat aaatgtgcat   2340

gaagcaggaa ggaactttac agtggcatgt caacatcgct ctaattcaga gataatctgt   2400

tgtaccactc cttccctgca acagctgaat ctgcaactcc ccctgaaaac caaagccttt   2460

ttcatgttag atgggatcct ttccaaatac tttgatctca tttatgtaca taatcctgtg   2520

tttaagcctt ttgaaaagcc agtgatgatc tcaatgggca atgaaaatgt actggaaatt   2580

aagggaaatg atattgaccc tgaagcagtt aaaggtgaag tgttaaaagt tggaaataag   2640

agctgtgaga atatacactt acattctgaa gccgttttat gcacggtccc caatgacctg   2700

ctgaaattga acagcgagct aaatatagag tggaagcaag caatttcttc aaccgtcctt   2760

ggaaaagtaa tagttcaacc agatcagaat ttcaca                             2796


<210>  4
<211>  932
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(932)

<400>  4

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr 
    930         


<210>  5
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Artifical sequence


<220>
<221>  primer
<222>  (1)..(20)

<400>  5
sargtrmagc tgmagsagtc                                                 20


<210>  6
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence


<220>
<221>  primer
<222>  (1)..(27)

<400>  6
aattttcttg tccaccttgg tgctgct                                         27


<210>  7
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence


<220>
<221>  primer
<222>  (1)..(21)

<400>  7
gayattgtdm tsacmcarwc t                                               21


<210>  8
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence


<220>
<221>  primer
<222>  (1)..(26)

<400>  8
ggatacagtt ggtgcagcat cagccc                                          26


<210>  9
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial sequence


<220>
<221>  peptide
<222>  (1)..(8)

<400>  9

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Artifical sequence


<220>
<221>  peptide
<222>  (1)..(8)

<400>  10

Ile Asp Pro Ser Asp Ser Glu Ser 
1               5               


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Artifical sequence


<220>
<221>  peptide
<222>  (1)..(15)

<400>  11

Ala Arg Ser Gly Tyr His Gly Thr Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial sequence


<220>
<221>  peptide
<222>  (1)..(11)

<400>  12

Lys Ser Leu Leu His Ser Asp Gly Ile Thr Tyr 
1               5                   10      


<210>  13
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial sequence


<220>
<221>  peptide
<222>  (1)..(3)

<400>  13

Gln Met Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial sequence


<220>
<221>  peptide
<222>  (1)..(9)

<400>  14

Ala Gln Asn Leu Glu Leu Pro Pro Thr 
1               5                   


