                         SEQUENCE LISTING

<110>  Ionis Pharmaceuticals, Inc.
       AstraZeneca AB
 
<120>  GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES
        THEREOF

<130>  BIOL0320US.L2

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  3
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  3

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25          


<210>  4
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  4

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25          


<210> 5
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Aib

<220>
<221> MOD_RES
<222> (29)..(29)
<223> Aib

<400> 5
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Phe Leu Val Arg Xaa Arg 
            20                  25                  30      


<210> 6
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Ala, Val, or Gly

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Gly, Lys, or Glu

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Gln or Lys

<220>
<221> MOD_RES
<222> (24)..(24)
<223> Ala or Glu

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Val or Lys

<220>
<221> MOD_RES
<222> (28)..(28)
<223> Lys, Asn, or Arg

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Arg or Gly

<220>
<221> MOD_RES
<222> (31)..(31)
<223> Gly, His, Pro, or not present

<400> 6
His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Xaa 
1               5                   10                  15      


Xaa Ala Ala Lys Glu Phe Ile Xaa Trp Leu Xaa Xaa Gly Xaa Xaa 
            20                  25                  30      


<210> 7
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 7
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210> 8
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 8
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Glu Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210> 9
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 9
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210> 10
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 10
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly 
            20                  25                  30      


<210> 11
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 11
His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly 
            20                  25                  30      


<210> 12
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 12
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Gly 
            20                  25                  30      


<210> 13
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 13
His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Gly 
            20                  25                  30      


<210> 14
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 14
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro 
            20                  25                  30      


<210> 15
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 15
His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro 
            20                  25                  30      


<210> 16
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 16
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30      


<210> 17
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 17
His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30      


<210> 18
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 18
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210> 19
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 19
His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210> 20
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 20
His Val Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Asn Gly Gly 
            20                  25                  30  


<210> 21
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Synthetic peptide


<400> 21
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Asn Gly Gly 
            20                  25                  30  

<210>  22
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  22

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  23
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is Penicillamine (Pen)

<400>  23

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  24
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  24

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Cys 
            20                  25                  30      


<210>  25
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  25

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  26
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  26

Ala Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  27
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is Penicillamine (Pen)

<400>  27

Ala Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  28
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  28

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val 
            20                  25          


<210>  29
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  29

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys 
            20                  25              


<210>  30
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  30

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  31
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  31

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210>  32
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  32

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro 
            20                  25                  30      


<210>  33
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  33

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


<210>  34
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  34

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser 
    


<210>  35
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  35

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly 
        


<210>  36
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  36

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala 
        35  


<210>  37
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  37

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro 
        35      


<210>  38
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is 4-azidonorleucine 

<400>  38

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  39
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  Xaa is 4-azidonorleucine

<400>  39

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Xaa 
            20                  25                  30          


<210>  40
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Lysine (5 azido pentanoic acid amide)

<400>  40

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Asn Xaa Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30          


<210>  41
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Xaa is 4-azidonorleucine

<400>  41

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa Arg Xaa 
            20                  25                  30          


<210>  42
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  Xaa is 4-azidonorleucine

<400>  42

His Ser Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Xaa 
            20                  25                  30      


<210>  43
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Xaa is 4-azidonorleucine

<400>  43

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Xaa 
        35              


<210>  44
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (44)..(44)
<223>  Xaa is 4-azidonorleucine 

<400>  44

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Xaa 
        


<210>  45
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is 4-azidonorleucine

<400>  45

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Xaa 
            20                  25                  


<210>  46
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is 4-azidonorleucine

<400>  46

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Xaa 
            20                  25              


<210>  47
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  47

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Cys 
            20                  25              


<210>  48
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is 4-azidonorleucine

<400>  48

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Xaa 
            20                  25          


<210>  49
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa is 4-azidonorleucine

<400>  49

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Xaa 
            20                  25      


<210>  50
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is 4-azidonorleucine

<400>  50

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Xaa 
            20  


<210>  51
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Xaa is 4-azidonorleucine
<400>  51

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Xaa 
            20                  25                  30  


<210>  52
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is 4-azidonorleucine

<400>  52

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Xaa 
            20                  25                  


<210>  53
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is 4-azidonorleucine

<400>  53

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Xaa 
            20                  25              


<210>  54
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is 4-azidonorleucine

<400>  54

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Xaa 
            20                  25          


<210>  55
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Xaa is 4-azidonorleucine

<400>  55

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Xaa 
            20                  25      


<210>  56
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is 4-azidonorleucine
<400>  56

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  57
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  57

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  58
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  58
tcagcattct aatagcagc                                                    19


<210>  59
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  59
tcatcttctt aaaataccc                                                    19


<210>  60
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  60
tcaggccaat acgccgtca                                                    19


<210>  61
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  61
tcagccaagg tctgaaggtc acc                                               23


<210>  62
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  62
gctgctatta gaatgc                                                       16


<210>  63
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  63
gcattctaat agcagc                                                       16


<210>  64
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  64
tcttcttaaa ataccc                                                       16


<210>  65
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  65
gcattctaat agcagc                                                       16


<210>  66
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  66
ccattctatc atcaacgggt acaa                                              24


<210>  67
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  67
agcaagtggg aaggtgtaat cc                                                22


<210>  68
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  68
cagtcacata cggccaatcc                                                   20


<210>  69
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  69
cgtaacttga tttgctgtcc tgaa                                              24


<210>  70
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  70
tgagcccttt gccccagatg cctat                                             25


<210>  71
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  71
gaggaatcag atgaggatat ggga                                              24


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  72
aagcaggctg acttggttgc                                                   20


<210>  73
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  73
tcggtctctt cgactaatcc cgccaa                                            26


<210>  74
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  74
aggcgttgtg cgtagaggat                                                   20


<210>  75
<211>  29
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  75
aaaggttacc ataagtaagt tccagaaaa                                         29


<210>  76
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Probe

<400>  76
agtggttggt aaaaatccgt gaggtcgg                                          28


<210>  77
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  77
ttatctataa tgatcaggta a                                                 21


<210>  78
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  siRNA

<400>  78
acctgatcat tatagataa                                                    19


<210>  79
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  79

Asp Leu Ser Lys Gln Met Glu Glu Glu Ala Val Arg Leu Phe Ile Glu  
1               5                   10                  15      


Trp Leu Lys Asn Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
            20                  25                  30          



