                         SEQUENCE LISTING

<110>  Bar-Ilan University
       RUTHSTEIN, Sharon
       SHENBERGER, Yulia
 
<120>  COPPER-CONTAINING COMPLEX AND USES THEREOF

<130>  75415

<150>  US 62/583,630
<151>  2017-11-09

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pep1 peptide amino acid sequence

<400>  1

Met Asp His Ser His His Met Gly Met Ser Tyr Met Asp Ser 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pep2 peptide amino acid sequence

<400>  2

Met Asp His Ser His His Met Ala Met Ser Tyr Met Asp Ser 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pep3 peptide amino acid sequence

<400>  3

Met Asp Ala Ser His His Met Gly Met Ser Tyr Met Asp Ser 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pep4 peptide amino acid sequence

<400>  4

Met Asp His Ser Ala His Met Gly Met Ser Tyr Met Asp Ser 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pep5 peptide amino acid sequence

<400>  5

Met Asp His Ser His Ala Met Gly Met Ser Tyr Met Asp Ser 
1               5                   10                  


<210>  6
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<400>  6

Cys Met Asp His Ser His His Met Gly Met Ser Tyr Met Asp Ser Cys 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<400>  7

Cys Ala Asp His Ser His His Met Gly Met Ser Tyr Met Asp Ser Cys 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<400>  8

Cys Met Asp His Ser His His Ala Gly Met Ser Tyr Met Asp Ser Cys 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<400>  9

Cys Met Asp His Ser His His Met Gly Ala Ser Tyr Met Asp Ser Cys 
1               5                   10                  15      


<210>  10
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  MTSSL 
       (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl 
       methanesulfonothioate) conjugate

<400>  10

Cys Met Asp His Ser His His Met Gly Met Ser Tyr Ala Asp Ser Cys 
1               5                   10                  15      


<210>  11
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary tetrapeptides amino acid sequence

<400>  11

His Ala Ala His 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary tetrapeptides amino acid sequence

<400>  12

His Ala Ala Met 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Exemplary tetrapeptides amino acid sequence

<400>  13

His Ala Ala Gly 
1               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Met 1 peptide sequence

<400>  14

Met Tyr Gly Met Lys Gly Met Ser 
1               5               


<210>  15
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Met2  peptide sequence

<400>  15

Met Tyr Gly Met Lys 
1               5   


<210>  16
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cys1 peptide sequence

<400>  16

Lys Ser Met Ala Ala Cys Ala Met 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cys2 peptide sequence

<400>  17

Ala Ser Cys Gly Gly Cys Ala Met 
1               5               


<210>  18
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cys3 peptide sequence

<400>  18

His Thr Gly Cys Lys 
1               5   


<210>  19
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Cys Xaa Xaa Met Xaa Xaa Met 
1               5           


<210>  20
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Cys Xaa Xaa His Xaa Xaa His 
1               5           


<210>  21
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Met Xaa Xaa His Xaa Xaa His 
1               5           


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mets motif amino acid sequence


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Met Xaa Xaa Xaa Xaa Met 
1               5       


<210>  23
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mets motif amino acid sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Met Xaa Xaa Xaa Met 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Met Xaa Xaa Xaa Cys 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  25

Met Xaa Xaa Xaa His 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Cys Xaa Xaa Xaa Met 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Cys Xaa Xaa Xaa Cys 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  28

Cys Xaa Xaa Xaa His 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  29

His Xaa Xaa Xaa Met 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

His Xaa Xaa Xaa Cys 
1               5   


<210>  31
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  31

Met Xaa Xaa Met 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Met Xaa Xaa Cys 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Met Xaa Xaa His 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Cys Xaa Xaa Met 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Cys Xaa Xaa Cys 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Cys Xaa Xaa His 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

His Xaa Xaa Met 
1               


<210>  38
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

His Xaa Xaa Cys 
1               


<210>  39
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

His Xaa Xaa Xaa His 
1               5   


<210>  40
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

His Xaa Xaa His 
1               


<210>  41
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Met Xaa Xaa Met Xaa Xaa Met 
1               5           


<210>  42
<211>  189
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ctr1 amino acid sequence

<400>  42

Met Asp His Ser His His Met Gly Met Ser Tyr Met Asp Ser Asn Ser 
1               5                   10                  15      


Thr Met Gln Pro Ser His His His Pro Thr Thr Ser Ala Ser His Ser 
            20                  25                  30          


His Gly Gly Gly Asp Ser Ser Met Met Met Met Pro Met Thr Phe Tyr 
        35                  40                  45              


Phe Gly Phe Lys Asn Val Glu Leu Leu Phe Ser Gly Leu Val Ile Asn 
    50                  55                  60                  


Thr Ala Gly Glu Met Ala Gly Ala Phe Val Ala Val Phe Leu Leu Ala 
65                  70                  75                  80  


Met Phe Tyr Glu Gly Leu Lys Ile Ala Arg Glu Ser Leu Leu Arg Lys 
                85                  90                  95      


Ser Gln Val Ser Ile Arg Tyr Asn Ser Met Pro Val Pro Gly Pro Asn 
            100                 105                 110         


Gly Thr Ile Leu Met Glu Thr His Thr Val Gly Gln Gln Met Leu Ser 
        115                 120                 125             


Phe Pro His Leu Leu Gln Thr Val Leu His Ile Ile Gln Val Val Ile 
    130                 135                 140                 


Ser Tyr Phe Leu Met Leu Ile Phe Met Thr Tyr Asn Gly Tyr Leu Cys 
145                 150                 155                 160 


Ile Ala Val Ala Ala Gly Ala Gly Thr Gly Tyr Phe Leu Phe Ser Trp 
                165                 170                 175     


Lys Lys Ala Val Val Val Asp Ile Thr Glu His Cys His 
            180                 185                 


<210>  43
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  native Ctr1 amino acid sequence with a 3 additional amino acids 
       at the N-terminus

<400>  43

Gly Thr Thr Met Asp His Ser His His Met Gly Met Ser Tyr Met Asp 
1               5                   10                  15      


Ser Asn Ser Thr Met Gln Pro Ser His His His Pro Thr Thr Ser Ala 
            20                  25                  30          


Ser His Ser His Gly Gly Gly Asp Ser Ser Met Met Met Met Pro Met 
        35                  40                  45              


Thr Phe Tyr Phe Gly Phe Lys Asn Val Glu Leu Leu Phe Ser Gly Leu 
    50                  55                  60                  


Val Ile Asn Thr Ala Gly Glu Met Ala Gly Ala Phe Val Ala Val Phe 
65                  70                  75                  80  


Leu Leu Ala Met Phe Tyr Glu Gly Leu Lys Ile Ala Arg Glu Ser Leu 
                85                  90                  95      


Leu Arg Lys Ser Gln Val Ser Ile Arg Tyr Asn Ser Met Pro Val Pro 
            100                 105                 110         


Gly Pro Asn Gly Thr Ile Leu Met Glu Thr His Thr Val Gly Gln Gln 
        115                 120                 125             


Met Leu Ser Phe Pro His Leu Leu Gln Thr Val Leu His Ile Ile Gln 
    130                 135                 140                 


Val Val Ile Ser Tyr Phe Leu Met Leu Ile Phe Met Thr Tyr Asn Gly 
145                 150                 155                 160 


Tyr Leu Cys Ile Ala Val Ala Ala Gly Ala Gly Thr Gly Tyr Phe Leu 
                165                 170                 175     


Phe Ser Trp Lys Lys Ala Val Val Val Asp Ile Thr Glu His Cys His 
            180                 185                 190         


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a His residue, a Met residue or a  Gly residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  X is Ala residue or Gly residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is a His residue, a Met residue or a  Gly residue

<400>  44

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is His residue, a Met residue or a Gly residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  X is Ala residue or a Gly residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is His residue, a Met residue or a Gly residue

<400>  45

Xaa Xaa Xaa Xaa 
1               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is a His, Met or Cys residue

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  X is a Ala, Arg, Asp, Glu, Gly, Lys, Ser, Thr or Tyr residue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is a His, Met or Cys residue

<400>  46

Xaa Xaa Xaa Xaa 
1               


<210>  47
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence

<400>  47

His Ala Gly Ala His 
1               5   


<210>  48
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence

<400>  48

His Gly Gly His 
1               


<210>  49
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence

<400>  49

His Thr Gly Met Lys 
1               5   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence

<400>  50

Met Tyr Gly Met Lys Gly Met Ser Tyr 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide sequence

<400>  51

Lys Ser Met Ala Ala Cys Ala Met Tyr 
1               5                   


