                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Compositions And Methods For Treating Cancer Using RHOA Dominant 
       Negative Forms

<130>  DFS-198.25

<140>  PCT/US2018/059188
<141>  2018-11-05

<150>  US 62/583,166
<151>  2017-11-08

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Asn Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210>  2
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Val Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210>  3
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Glu Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Ala Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val 
            180                 185                 190         


Leu 
    


<210>  4
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  4
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtgg aaagaattgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  5
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  5
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtgg aaagaactgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  6
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  6
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtgt taagacatgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  7
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  7
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtgt caagacatgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  8
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  8
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtgt gaagacatgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  9
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  9
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtgt aaagacatgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  10
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  10
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtga aaagacatgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  11
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  11
atggctgcca tccggaagaa actggtgatt gttggtgatg gagcctgtga gaagacatgc       60

ttgctcatag tcttcagcaa ggaccagttc ccagaggtgt atgtgcccac agtgtttgag      120

aactatgtgg cagatatcga ggtggatgga aagcaggtag agttggcttt gtgggacaca      180

gctgggcagg aagattatga tcgcctgagg cccctctcct acccagatac cgatgttata      240

ctgatgtgtt tttccatcga cagccctgat agtttagaaa acatcccaga aaagtggacc      300

ccagaagtca agcatttctg tcccaacgtg cccatcatcc tggttgggaa taagaaggat      360

cttcggaatg atgagcacac aaggcgggag ctagccaaga tgaagcagga gccggtgaaa      420

cctgaagaag gcagagatat ggcaaacagg attggcgctt ttgggtacat ggagtgttca      480

gcaaagacca aagatggagt gagagaggtt tttgaaatgg ctacgagagc tgctctgcaa      540

gctagacgtg ggaagaaaaa atctgggtgc cttgtcttgt ga                         582


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: linker amino acid 
       sequence"

<400>  12

Gly Gly Gly Gly Ala Gly Gly Gly Gly 
1               5                   