                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  CHIMERIC ANTIGEN RECEPTORS TARGETING TUMOR ANTIGENS

<130>  4239-99836-02

<150>  US 62/584,421
<151>  2017-11-10

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (GMCSFRss)

<400>  1
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atccca                                                                  66


<210>  2
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide (GMCSFRss)

<400>  2

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  3
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (CD8alpha hinge)

<400>  3
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgac                                                       135


<210>  4
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (CD8alpha hinge)

<400>  4

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  5
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (CD8alpha TM)

<400>  5
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

acc                                                                     63


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (CD8alpha TM)

<400>  6

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  7
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (4-1BB)

<400>  7
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (4-1BB)

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (CD3zeta signaling domain)

<400>  9
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (CD3zeta signaling domain)

<400>  10

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  11
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (T2A)

<400>  11
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct             54


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide (T2A)

<400>  12

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  13
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (huEGFRt)

<400>  13
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga      720

cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag      780

acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta cgcagacgcc      840

ggccatgtgt gccacctgtg ccatccaaac tgcacctacg gatgcactgg gccaggtctt      900

gaaggctgtc caacgaatgg gcctaagatc ccgtccatcg ccactgggat ggtgggggcc      960

ctcctcttgc tgctggtggt ggccctgggg atcggcctct tcatg                     1005


<210>  14
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (huEGFRt)

<400>  14

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  15
<211>  2601
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pMH289)

<400>  15
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacata tggaggtgca gcttgttgag tctggtggag gattggtgca gcctggaggg      120

tcattgagac tctcatgtgc agcctctgga ttcaccttca ataagaatgc catgaattgg      180

gtccgccagg ctccaggaaa gggtttggaa tgggttggcc gcataagaaa taaaactaat      240

aattatgcaa catattatgc cgattcagtg aaagccaggt ttaccatctc cagagatgat      300

tcaaagaact cactctatct gcaaatgaac agcttgaaaa ccgaggacac agccgtgtac      360

tattgtgtgg ctggtaactc gtttgcttac tggggccaag ggactctggt cactgtctct      420

gcaggcggag gcggatcagg tggtggcgga tctggaggtg gcggaagcga cattgtgatg      480

acccagtctc cagactccct agctgtgtca ctgggagaga gggccactat caactgcaag      540

tccagtcaga gccttttata tagcagcaat caaaagaact acttggcctg gtaccaacag      600

aaaccagggc agcctcctaa actgctgatt tactgggcat ccagtaggga atctggggtc      660

cctgatcgct tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      720

caggctgaag acgtggcagt ttattactgt cagcaatatt ataactatcc gctcacgttc      780

ggtcagggga ccaagttgga gatcaaaact agtaccacga cgccagcgcc gcgaccacca      840

acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gtgccggcca      900

gcggcggggg gcgcagtgca cacgaggggg ctggacttcg cctgtgacat ctacatctgg      960

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgcgagggca gaggaagtct tctaacatgc     1500

ggtgacgtgg aggagaatcc cggccctatg cttctcctgg tgacaagcct tctgctctgt     1560

gagttaccac acccagcatt cctcctgatc ccacgcaaag tgtgtaacgg aataggtatt     1620

ggtgaattta aagactcact ctccataaat gctacgaata ttaaacactt caaaaactgc     1680

acctccatca gtggcgatct ccacatcctg ccggtggcat ttaggggtga ctccttcaca     1740

catactcctc ctctggatcc acaggaactg gatattctga aaaccgtaaa ggaaatcaca     1800

gggtttttgc tgattcaggc ttggcctgaa aacaggacgg acctccatgc ctttgagaac     1860

ctagaaatca tacgcggcag gaccaagcaa catggtcagt tttctcttgc agtcgtcagc     1920

ctgaacataa catccttggg attacgctcc ctcaaggaga taagtgatgg agatgtgata     1980

atttcaggaa acaaaaattt gtgctatgca aatacaataa actggaaaaa actgtttggg     2040

acctccggtc agaaaaccaa aattataagc aacagaggtg aaaacagctg caaggccaca     2100

ggccaggtct gccatgcctt gtgctccccc gagggctgct ggggcccgga gcccagggac     2160

tgcgtctctt gccggaatgt cagccgaggc agggaatgcg tggacaagtg caaccttctg     2220

gagggtgagc caagggagtt tgtggagaac tctgagtgca tacagtgcca cccagagtgc     2280

ctgcctcagg ccatgaacat cacctgcaca ggacggggac cagacaactg tatccagtgt     2340

gcccactaca ttgacggccc ccactgcgtc aagacctgcc cggcaggagt catgggagaa     2400

aacaacaccc tggtctggaa gtacgcagac gccggccatg tgtgccacct gtgccatcca     2460

aactgcacct acggatgcac tgggccaggt cttgaaggct gtccaacgaa tgggcctaag     2520

atcccgtcca tcgccactgg gatggtgggg gccctcctct tgctgctggt ggtggccctg     2580

gggatcggcc tcttcatgtg a                                               2601


<210>  16
<211>  866
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (hYP7-CAR)

<400>  16

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro His Met Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Asn Lys Asn Ala Met Asn Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Arg Asn Lys Thr Asn 
65                  70                  75                  80  


Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asp Ser Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val Ala Gly Asn Ser Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr 
                165                 170                 175     


Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys 
            180                 185                 190         


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr 
                245                 250                 255     


Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr Ser Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser 
                485                 490                 495     


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu 
            500                 505                 510         


Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu 
        515                 520                 525             


Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys 
    530                 535                 540                 


Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys 
545                 550                 555                 560 


Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly 
                565                 570                 575     


Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile 
            580                 585                 590         


Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp 
        595                 600                 605             


Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile 
    610                 615                 620                 


Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser 
625                 630                 635                 640 


Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp 
                645                 650                 655     


Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr 
            660                 665                 670         


Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile 
        675                 680                 685             


Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys 
    690                 695                 700                 


His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp 
705                 710                 715                 720 


Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys 
                725                 730                 735     


Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu 
            740                 745                 750         


Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr 
        755                 760                 765             


Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile 
    770                 775                 780                 


Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu 
785                 790                 795                 800 


Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His 
                805                 810                 815     


Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu 
            820                 825                 830         


Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met 
        835                 840                 845             


Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu 
    850                 855                 860                 


Phe Met 
865     


<210>  17
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pMH288)

<400>  17
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacata tgcaggtgca gctggtgcag tctgggggag gcttggtaca gcctggaggg      120

tccctgagac tctcctgtgc agcctcttat ttcgatttcg attcttatga aatgagctgg      180

gtccgccagg ctccagggaa gggcctagag tggattggga gtatctatca tagtgggagc      240

acctactaca acccgtccct caagagtcga gtcaccatct ccagagacaa ttccaagaac      300

acgctgtatc tgcaaatgaa caccctgaga gccgaggaca cagccacgta ttactgtgcg      360

agagtaaata tggaccgatt tgactactgg ggccagggaa ccctggtcac cgtctcctca      420

actagtacca cgacgccagc gccgcgacca ccaacaccgg cgcccaccat cgcgtcgcag      480

cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg ggggcgcagt gcacacgagg      540

gggctggact tcgcctgtga catctacatc tgggcgccct tggccgggac ttgtggggtc      600

cttctcctgt cactggttat caccaaacgg ggcagaaaga aactcctgta tatattcaaa      660

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt      720

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc      780

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      840

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      900

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      960

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1020

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1080

cctcgcgagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct     1140

atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg     1200

atcccacgca aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata     1260

aatgctacga atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc     1320

ctgccggtgg catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa     1380

ctggatattc tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct     1440

gaaaacagga cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag     1500

caacatggtc agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc     1560

tccctcaagg agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat     1620

gcaaatacaa taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata     1680

agcaacagag gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc     1740

cccgagggct gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga     1800

ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag     1860

aactctgagt gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc     1920

acaggacggg gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc     1980

gtcaagacct gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca     2040

gacgccggcc atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca     2100

ggtcttgaag gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg     2160

ggggccctcc tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gtga           2214


<210>  18
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (HN3-CAR)

<400>  18

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro His Met Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Tyr Phe Asp Phe Asp Ser Tyr Glu Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Val Asn Met Asp Arg Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Thr Thr 
    130                 135                 140                 


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
145                 150                 155                 160 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
                165                 170                 175     


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
            180                 185                 190         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        195                 200                 205             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    210                 215                 220                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
225                 230                 235                 240 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                245                 250                 255     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            260                 265                 270         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        275                 280                 285             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    290                 295                 300                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
305                 310                 315                 320 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                325                 330                 335     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            340                 345                 350         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu 
        355                 360                 365             


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu 
    370                 375                 380                 


Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu 
385                 390                 395                 400 


Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp 
                405                 410                 415     


Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr 
            420                 425                 430         


Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp 
        435                 440                 445             


Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu 
    450                 455                 460                 


Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro 
465                 470                 475                 480 


Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg 
                485                 490                 495     


Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu 
            500                 505                 510         


Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly 
        515                 520                 525             


Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile 
    530                 535                 540                 


Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile 
545                 550                 555                 560 


Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His 
                565                 570                 575     


Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys 
            580                 585                 590         


Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys 
        595                 600                 605             


Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys 
    610                 615                 620                 


Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys 
625                 630                 635                 640 


Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
                645                 650                 655     


Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
            660                 665                 670         


Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
        675                 680                 685             


Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
    690                 695                 700                 


Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val 
705                 710                 715                 720 


Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe 
                725                 730                 735     


Met 
    


<210>  19
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (pMH290)

<400>  19
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacata tgcaggtgca gctggtgcag tctgggggag gcttggtaca gcctggaggg      120

tccctgagac tctcctgtgc agcctctgat ttctatttct atgattatga aatgagctgg      180

gtccgccagg ctccagggaa gggtctggag tggattggga ctgtctccta tagtgggagc      240

acctactaca acccgtccct caagagtcga gtcaccatct ccagagacaa ttccaagaac      300

acgctgtatc tgcaaatgaa caccctaaga gccgaggaca cagccatgta ttactgtgcg      360

agaggttaca gctatgatga ctcccgatat tttgactact ggggccaggg aaccctggtc      420

accgtctcct caactagtac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      480

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      540

gtgcacacga gggggctgga cttcgcctgt gacatctaca tctgggcgcc cttggccggg      600

acttgtgggg tccttctcct gtcactggtt atcaccaaac ggggcagaaa gaaactcctg      660

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      720

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg      780

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta      840

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg      900

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag      960

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1020

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1080

caggccctgc cccctcgcga gggcagagga agtcttctaa catgcggtga cgtggaggag     1140

aatcccggcc ctatgcttct cctggtgaca agccttctgc tctgtgagtt accacaccca     1200

gcattcctcc tgatcccacg caaagtgtgt aacggaatag gtattggtga atttaaagac     1260

tcactctcca taaatgctac gaatattaaa cacttcaaaa actgcacctc catcagtggc     1320

gatctccaca tcctgccggt ggcatttagg ggtgactcct tcacacatac tcctcctctg     1380

gatccacagg aactggatat tctgaaaacc gtaaaggaaa tcacagggtt tttgctgatt     1440

caggcttggc ctgaaaacag gacggacctc catgcctttg agaacctaga aatcatacgc     1500

ggcaggacca agcaacatgg tcagttttct cttgcagtcg tcagcctgaa cataacatcc     1560

ttgggattac gctccctcaa ggagataagt gatggagatg tgataatttc aggaaacaaa     1620

aatttgtgct atgcaaatac aataaactgg aaaaaactgt ttgggacctc cggtcagaaa     1680

accaaaatta taagcaacag aggtgaaaac agctgcaagg ccacaggcca ggtctgccat     1740

gccttgtgct cccccgaggg ctgctggggc ccggagccca gggactgcgt ctcttgccgg     1800

aatgtcagcc gaggcaggga atgcgtggac aagtgcaacc ttctggaggg tgagccaagg     1860

gagtttgtgg agaactctga gtgcatacag tgccacccag agtgcctgcc tcaggccatg     1920

aacatcacct gcacaggacg gggaccagac aactgtatcc agtgtgccca ctacattgac     1980

ggcccccact gcgtcaagac ctgcccggca ggagtcatgg gagaaaacaa caccctggtc     2040

tggaagtacg cagacgccgg ccatgtgtgc cacctgtgcc atccaaactg cacctacgga     2100

tgcactgggc caggtcttga aggctgtcca acgaatgggc ctaagatccc gtccatcgcc     2160

actgggatgg tgggggccct cctcttgctg ctggtggtgg ccctggggat cggcctcttc     2220

atgtga                                                                2226


<210>  20
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (LH7-CAR)

<400>  20

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro His Met Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Asp Phe Tyr Phe Tyr Asp Tyr Glu Met Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Thr Val Ser Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Tyr Asp Asp Ser 
        115                 120                 125             


Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
145                 150                 155                 160 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                165                 170                 175     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            180                 185                 190         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        195                 200                 205             


Leu Val Ile Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    210                 215                 220                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
225                 230                 235                 240 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                245                 250                 255     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            260                 265                 270         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        275                 280                 285             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    290                 295                 300                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
305                 310                 315                 320 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                325                 330                 335     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            340                 345                 350         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gly 
        355                 360                 365             


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
    370                 375                 380                 


Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
385                 390                 395                 400 


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
                405                 410                 415     


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
            420                 425                 430         


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
        435                 440                 445             


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
    450                 455                 460                 


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
465                 470                 475                 480 


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
                485                 490                 495     


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
            500                 505                 510         


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
        515                 520                 525             


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
    530                 535                 540                 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
545                 550                 555                 560 


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
                565                 570                 575     


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
            580                 585                 590         


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
        595                 600                 605             


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
    610                 615                 620                 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
625                 630                 635                 640 


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
                645                 650                 655     


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
            660                 665                 670         


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
        675                 680                 685             


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
    690                 695                 700                 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
705                 710                 715                 720 


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
                725                 730                 735     


Ile Gly Leu Phe Met 
            740     


<210>  21
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (YP7 VH domain)

<400>  21
gaggtgcagc ttgttgagac tggtggagga atggtgcagc ctgaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat aagaatgcca tgaattgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaaata aaactaataa ttatgcaaca      180

tattatgccg attcagtgaa agccaggttt accatctcca gagatgattc acaaagcatg      240

ctctatctgc aaatgaacaa cttgaaaatt gaggacacag ccatgtacta ttgtgtggct      300

ggtaactcgt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (YP7 VH domain)

<400>  22

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  23
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (YP7 VL domain)

<400>  23
gacattgtga tgtcacagtc tccatcctcc ctagttgtgt caattggaga gaaggttact       60

atgacctgca agtccagtca gagcctttta tatagcagca atcaaaagaa ctacttggcc      120

tggtaccaac agaaaccagg gcagtctcct aaactgctga tttactgggc atccagtagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttattact gtcagcaata ttataactat      300

ccgctcacgt tcggtgctgg gaccaagttg gagctgaaa                             339


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (YP7 VL domain)

<400>  24

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  25
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (hYP7 VH domain)

<400>  25
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctggagggtc attgagactc       60

tcatgtgcag cctctggatt caccttcaat aagaatgcca tgaattgggt ccgccaggct      120

ccaggaaagg gtttggaatg ggttggccgc ataagaaata aaactaataa ttatgcaaca      180

tattatgccg attcagtgaa agccaggttt accatctcca gagatgattc aaagaactca      240

ctctatctgc aaatgaacag cttgaaaacc gaggacacag ccgtgtacta ttgtgtggct      300

ggtaactcgt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (hYP7 VH domain)

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  27
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (hYP7 VL domain)

<400>  27
gacattgtga tgacccagtc tccagactcc ctagctgtgt cactgggaga gagggccact       60

atcaactgca agtccagtca gagcctttta tatagcagca atcaaaagaa ctacttggcc      120

tggtaccaac agaaaccagg gcagcctcct aaactgctga tttactgggc atccagtagg      180

gaatctgggg tccctgatcg cttcagtggc agtggatctg ggacagattt cactctcacc      240

atcagcagtc tgcaggctga agacgtggca gtttattact gtcagcaata ttataactat      300

ccgctcacgt tcggtcaggg gaccaagttg gagatcaaa                             339


<210>  28
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (hYP7 VL domain)

<400>  28

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  29
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (HN3)

<400>  29
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttattt cgatttcgat tcttatgaaa tgagctgggt ccgccaggct      120

ccagggaagg gcctagagtg gattgggagt atctatcata gtgggagcac ctactacaac      180

ccgtccctca agagtcgagt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca ccctgagagc cgaggacaca gccacgtatt actgtgcgag agtaaatatg      300

gaccgatttg actactgggg ccagggaacc ctggtcaccg tctcctcaag t               351


<210>  30
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (HN3)

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Phe Asp Phe Asp Ser Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Asn Met Asp Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ser 
        115         


<210>  31
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (LH7)

<400>  31
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctgattt ctatttctat gattatgaaa tgagctgggt ccgccaggct      120

ccagggaagg gtctggagtg gattgggact gtctcctata gtgggagcac ctactacaac      180

ccgtccctca agagtcgagt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca ccctaagagc cgaggacaca gccatgtatt actgtgcgag aggttacagc      300

tatgatgact cccgatattt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  32
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (LH7)

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Tyr Phe Tyr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Val Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Ser Tyr Asp Asp Ser Arg Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (LH4)

<400>  33
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctcttcttt ctatttcgat gattatgaaa tgagctgggt ccgccaggct      120

ccagggaagg ccctggagtg gattgggcgt atctatacca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatctcc agagacaatt ccaagaacac gctgtatctg      240

caaatgaaca ccctgagagc cgaggacaca gccacgtatt actgtgcgag gggatattgt      300

agtggtggta gctgctactt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  34
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (LH4)

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Tyr Phe Asp Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Cys Ser Gly Gly Ser Cys Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  35
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (LH6)

<400>  35
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctgattt ctatttcgat gattatgaaa tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaact attagtggta gtggtggtgg cacatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccacat attactgtgc gagaggttac      300

agttatgacg actcccgata ttttgactac tggggccagg gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  36
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (LH6)

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Tyr Phe Asp Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Tyr Asp Asp Ser Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  37
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (YP218 VH domain)

<400>  37
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctgagggatc cctgacactc       60

acctgcaaag cctctggatt cgacctcggt ttctactttt acgcctgttg ggtccgccag      120

gctccaggga agggcctgga gtggatcgca tgcatttata ctgctggtag tggtagcacg      180

tactacgcga gctgggcgaa aggccgattc accatctcca aagcctcgtc gaccacggtg      240

actctgcaaa tgaccagtct ggcagccgcg gacacggcca cctatttctg tgcgagatct      300

actgctaata ctagaagtac ttattatctt aacttgtggg gcccaggcac cctggtcacc      360

gtctcctca                                                              369


<210>  38
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (YP218 VH domain)

<400>  38

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Leu Gly Phe Tyr 
            20                  25                  30          


Phe Tyr Ala Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Ala Gly Ser Gly Ser Thr Tyr Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Ser Leu Ala Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ser Thr Ala Asn Thr Arg Ser Thr Tyr Tyr Leu Asn Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  39
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (YP218 VL domain)

<400>  39
gacgtcgtga tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gaggattagt agttacttat cctggtatca gcagaaacca      120

gggcagcgtc ccaagctcct gatctttggt gcatccactc tggcatctgg ggtcccctcg      180

cggttcaaag gcagtggatc tgggacagaa tacactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcagagt tatgcttatt ttgatagtaa taattggcat      300

gctttcggcg gagggaccga ggtggtggtc                                       330


<210>  40
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (YP218 VL domain)

<400>  40

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Arg Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Ala Tyr Phe Asp Ser 
                85                  90                  95      


Asn Asn Trp His Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110 


<210>  41
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide (SD1)

<400>  41
caggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctgattt cgatttcgct gcttatgaaa tgagctgggt ccgccaggct      120

ccaggacaag gccttgagtg ggtggcaatt atatcacatg atggaatcga taaatactac      180

acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acaccctgag agccgaggac acagccacgt attactgttt aaggcttggt      300

gctgtaggcc agggaaccct ggtcaccgtc tcctcaagt                             339


<210>  42
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide (SD1)

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Asp Phe Ala Ala Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser His Asp Gly Ile Asp Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Leu Arg Leu Gly Ala Val Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ser 
    


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  43
gcagtctctg gaagaaggag                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  44
tggtgacagg tggcgtccgg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  45
cggttttcca aggtgagttc                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  46
ggtcacgtct tgctcctcgg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  47
gacatcaatg agtgcctccg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  48
gataataagc agatctatat                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  49
cgttttccgc cacagggcta                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  50
agggtgtcgt tttccgccac                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  51
gaggcagagc aggtagtcag                                                   20


