                         SEQUENCE LISTING

<110>  The General Hospital Corporation
 
<120>  ANTAGONISTIC ANTI-TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY 
       POLYPEPTIDES

<130>  00786-580WO3

<150>  US 62/647,254
<151>  2018-03-23

<150>  US 62/583,897
<151>  2017-11-09

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ser Thr Tyr Thr Gln Leu 
1               5           


<210>  3
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Glu Cys Leu Ser Cys Gly Ser 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ile Cys Thr Cys Arg Pro Gly 
1               5               


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Cys Ser Pro Gly 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val 
1               5                   10                  15      


Pro 
    


<210>  7
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser 
1               5                   10                  15      


Ser Asp 
        


<210>  8
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala 
1               5                   10                  15      


Lys Val Phe Cys 
            20  


<210>  9
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Cys Arg Pro Gly 
1               5   


<210>  10
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Glu Asn Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Gly Ala Val Ser Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 


<210>  12
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  12

Ala Asp Ala Ala Pro 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Val Ala Ala Pro 
1               5   


<210>  14
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  14

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
1               5                   10      


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Pro Lys Ala Ala Pro 
1               5       


<210>  17
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
1               5                   10              


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Gly Gly Ser Gly Gly 
1               5   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic Construct

<400>  20

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10              


<210>  21
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  21

Ala Lys Thr Thr Ala Pro 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ser Thr Lys Gly Pro 
1               5       


<210>  23
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  23

Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
1               5                   10              


<210>  24
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Gly Gly Gly Gly Ser Gly 
1               5       


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  28
<211>  458
<212>  PRT
<213>  Bison bison

<400>  28

Met Ala Pro Thr Ala Phe Trp Ala Ala Leu Ala Val Gly Leu Gln Phe 
1               5                   10                  15      


Trp Ala Ala Gly Arg Ala Val Pro Ala Gln Ala Val Phe Thr Pro Tyr 
            20                  25                  30          


Ile Pro Glu Pro Gly Ser Ser Cys Arg Gln Gln Glu Tyr Tyr Asn His 
        35                  40                  45              


Lys Ile Gln Met Cys Cys Ser Lys Cys Pro Pro Gly Tyr Arg Val Gln 
    50                  55                  60                  


Ser Leu Cys Asn Thr Thr Leu Asp Thr Ile Cys Ala Ser Cys Glu Ser 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Leu Val Thr Ala Cys Phe Ser Cys 
                85                  90                  95      


Asn Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Thr 
            100                 105                 110         


Lys Gln Asn Arg Ile Cys Thr Cys Lys Pro Gly Trp Tyr Cys Thr Leu 
        115                 120                 125             


Gly Arg Gln Glu Gly Cys Arg Leu Cys Val Ala Leu Arg Lys Cys Gly 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Lys Pro Gly Thr Ala Thr Thr Asn Val Ile 
145                 150                 155                 160 


Cys Ala Pro Cys Gly Pro Gly Thr Phe Ser Asp Thr Thr Ser Tyr Thr 
                165                 170                 175     


Asp Thr Cys Lys Pro His Arg Asn Cys Ser Ser Val Ala Ile Pro Gly 
            180                 185                 190         


Thr Ala Ser Thr Asp Ala Val Cys Thr Ser Val Leu Pro Thr Arg Lys 
        195                 200                 205             


Val Ala Arg Gly Pro Ala Thr Thr Arg Ser Gln His Met Glu Pro Thr 
    210                 215                 220                 


Leu Gly Pro Ser Thr Ala Pro Ser Thr Phe Phe Leu Leu Pro Lys Val 
225                 230                 235                 240 


Pro Ser Pro Pro Ser Ser Pro Val Glu Gln Pro Asn Ala Gly Asn Ile 
                245                 250                 255     


Ser Leu Pro Ile Glu Leu Ile Val Gly Val Thr Ala Leu Gly Leu Leu 
            260                 265                 270         


Leu Ile Val Val Val Asn Cys Val Ile Met Thr Gln Lys Lys Lys Lys 
        275                 280                 285             


Pro Phe Cys Leu Gln Gly Asp Ala Lys Val Pro His Leu Pro Ala Asn 
    290                 295                 300                 


Lys Ala Gln Gly Ala Pro Gly Pro Glu Gln Gln His Leu Leu Thr Thr 
305                 310                 315                 320 


Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Thr Ser Ser Thr 
                325                 330                 335     


Asp Lys Arg Ala Pro Thr Arg Ser Gln Leu Gln Ser Pro Gly Val Glu 
            340                 345                 350         


Ala Asn Thr Ser Gly Glu Ala Gln Thr Gly Cys Ser Ser Ser Glu Ala 
        355                 360                 365             


Ser Ser Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile Val Asn 
    370                 375                 380                 


Val Cys Ser Gly Pro Asp His Ser Ser Gln Cys Pro Ser Gln Ala Gly 
385                 390                 395                 400 


Ser Thr Arg Asp Thr Asp Ala Ser Thr Pro Asn Ser Pro Lys Glu Glu 
                405                 410                 415     


Gln Val Pro Phe Ser Lys Glu Glu Arg Pro Phe Gln Ser Gln Pro Gly 
            420                 425                 430         


Ala Pro Glu Thr Leu Leu Gln Gly Leu Glu Glu Lys Pro Leu Pro Leu 
        435                 440                 445             


Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455             


<210>  29
<211>  474
<212>  PRT
<213>  Mus musculus

<400>  29

Met Ala Pro Ala Ala Leu Trp Val Ala Leu Val Phe Glu Leu Gln Leu 
1               5                   10                  15      


Trp Ala Thr Gly His Thr Val Pro Ala Gln Val Val Leu Thr Pro Tyr 
            20                  25                  30          


Lys Pro Glu Pro Gly Tyr Glu Cys Gln Ile Ser Gln Glu Tyr Tyr Asp 
        35                  40                  45              


Arg Lys Ala Gln Met Cys Cys Ala Lys Cys Pro Pro Gly Gln Tyr Val 
    50                  55                  60                  


Lys His Phe Cys Asn Lys Thr Ser Asp Thr Val Cys Ala Asp Cys Glu 
65                  70                  75                  80  


Ala Ser Met Tyr Thr Gln Val Trp Asn Gln Phe Arg Thr Cys Leu Ser 
                85                  90                  95      


Cys Ser Ser Ser Cys Thr Thr Asp Gln Val Glu Ile Arg Ala Cys Thr 
            100                 105                 110         


Lys Gln Gln Asn Arg Val Cys Ala Cys Glu Ala Gly Arg Tyr Cys Ala 
        115                 120                 125             


Leu Lys Thr His Ser Gly Ser Cys Arg Gln Cys Met Arg Leu Ser Lys 
    130                 135                 140                 


Cys Gly Pro Gly Phe Gly Val Ala Ser Ser Arg Ala Pro Asn Gly Asn 
145                 150                 155                 160 


Val Leu Cys Lys Ala Cys Ala Pro Gly Thr Phe Ser Asp Thr Thr Ser 
                165                 170                 175     


Ser Thr Asp Val Cys Arg Pro His Arg Ile Cys Ser Ile Leu Ala Ile 
            180                 185                 190         


Pro Gly Asn Ala Ser Thr Asp Ala Val Cys Ala Pro Glu Ser Pro Thr 
        195                 200                 205             


Leu Ser Ala Ile Pro Arg Thr Leu Tyr Val Ser Gln Pro Glu Pro Thr 
    210                 215                 220                 


Arg Ser Gln Pro Leu Asp Gln Glu Pro Gly Pro Ser Gln Thr Pro Ser 
225                 230                 235                 240 


Ile Leu Thr Ser Leu Gly Ser Thr Pro Ile Ile Glu Gln Ser Thr Lys 
                245                 250                 255     


Gly Gly Ile Ser Leu Pro Ile Gly Leu Ile Val Gly Val Thr Ser Leu 
            260                 265                 270         


Gly Leu Leu Met Leu Gly Leu Val Asn Cys Ile Ile Leu Val Gln Arg 
        275                 280                 285             


Lys Lys Lys Pro Ser Cys Leu Gln Arg Asp Ala Lys Val Pro His Val 
    290                 295                 300                 


Pro Asp Glu Lys Ser Gln Asp Ala Val Gly Leu Glu Gln Gln His Leu 
305                 310                 315                 320 


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
                325                 330                 335     


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
            340                 345                 350         


Val Met Ala Glu Ala Gln Gly Phe Gln Glu Ala Arg Ala Ser Ser Arg 
        355                 360                 365             


Ile Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
    370                 375                 380                 


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
385                 390                 395                 400 


Ser Gln Ala Ser Ala Thr Val Gly Asp Pro Asp Ala Lys Pro Ser Ala 
                405                 410                 415     


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
            420                 425                 430         


Gln Ser Pro Cys Glu Thr Thr Glu Thr Leu Gln Ser His Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Met Gly Met Lys Pro Ser Gln Ala Gly 
    450                 455                 460                 


Trp Phe Asp Gln Ile Ala Val Lys Val Ala 
465                 470                 


<210>  30
<211>  474
<212>  PRT
<213>  Rattus norvegicus

<400>  30

Met Ala Pro Ala Ala Leu Trp Val Ala Leu Val Val Glu Leu Gln Leu 
1               5                   10                  15      


Trp Ala Thr Gly His Thr Val Pro Ala Lys Val Val Leu Thr Pro Tyr 
            20                  25                  30          


Lys Pro Glu Pro Gly Asn Gln Cys Gln Ile Ser Gln Glu Tyr Tyr Asp 
        35                  40                  45              


Lys Lys Ala Gln Met Cys Cys Ala Lys Cys Pro Pro Gly Gln Tyr Ala 
    50                  55                  60                  


Lys His Phe Cys Asn Lys Thr Ser Asp Thr Val Cys Ala Asp Cys Ala 
65                  70                  75                  80  


Ala Gly Met Phe Thr Gln Val Trp Asn His Leu His Thr Cys Leu Ser 
                85                  90                  95      


Cys Ser Ser Ser Cys Ser Asp Asp Gln Val Glu Thr His Asn Cys Thr 
            100                 105                 110         


Lys Lys Gln Asn Arg Val Cys Ala Cys Asn Ala Asp Ser Tyr Cys Ala 
        115                 120                 125             


Leu Lys Leu His Ser Gly Asn Cys Arg Gln Cys Met Lys Leu Ser Lys 
    130                 135                 140                 


Cys Gly Pro Gly Phe Gly Val Ala Arg Ser Arg Thr Ser Asn Gly Asn 
145                 150                 155                 160 


Val Ile Cys Ser Ala Cys Ala Pro Gly Thr Phe Ser Asp Thr Thr Ser 
                165                 170                 175     


Ser Thr Asp Val Cys Arg Pro His Arg Ile Cys Ser Ile Leu Ala Ile 
            180                 185                 190         


Pro Gly Asn Ala Ser Thr Asp Ala Val Cys Ala Ser Glu Ser Pro Thr 
        195                 200                 205             


Pro Ser Ala Val Pro Arg Thr Ile Tyr Val Ser Gln Pro Glu Pro Thr 
    210                 215                 220                 


Arg Ser Gln Pro Met Asp Gln Glu Pro Gly Pro Ser Gln Thr Pro His 
225                 230                 235                 240 


Ile Pro Val Ser Leu Gly Ser Thr Pro Ile Ile Glu Pro Ser Ile Thr 
                245                 250                 255     


Gly Gly Ile Ser Leu Pro Ile Gly Leu Ile Val Gly Leu Thr Thr Leu 
            260                 265                 270         


Gly Leu Leu Met Leu Gly Leu Ala Asn Cys Phe Ile Leu Val Gln Arg 
        275                 280                 285             


Lys Lys Lys Pro Ser Cys Leu Gln Arg Glu Thr Met Val Pro His Leu 
    290                 295                 300                 


Pro Asp Asp Lys Ser Gln Asp Ala Ile Gly Leu Glu Gln Gln His Leu 
305                 310                 315                 320 


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
                325                 330                 335     


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
            340                 345                 350         


Val Thr Ala Glu Ala Gln Gly Ser Gln Glu Ala Cys Ala Gly Ser Arg 
        355                 360                 365             


Ser Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
    370                 375                 380                 


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
385                 390                 395                 400 


Ser Gln Ala Ser Thr Thr Val Gly Asp Pro Asp Ala Asn Pro Ser Gly 
                405                 410                 415     


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
            420                 425                 430         


Gln Ser Gln Trp Glu Thr Thr Glu Thr Leu Gln Asn His Asp Lys Pro 
        435                 440                 445             


Phe Pro Leu Gly Val Pro Asp Val Gly Met Lys Pro Asn Gln Pro Gly 
    450                 455                 460                 


Trp Tyr Asp Gln Ile Ala Val Lys Val Pro 
465                 470                 


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Ser Thr Asp Ile Cys Arg Pro His Gln Ile 
1               5                   10      


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Ala Leu Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu 
1               5                   10                  15  


<210>  33
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  33

Thr Ser Asp Val Val Cys Lys Pro Cys Ala 
1               5                   10  


<210>  34
<211>  459
<212>  PRT
<213>  Bos taurus

<400>  34

Met Ala Pro Thr Ala Phe Trp Ala Ala Leu Ala Val Gly Leu Gln Phe 
1               5                   10                  15      


Trp Ala Ala Gly Arg Ala Val Pro Ala Gln Ala Val Phe Thr Pro Tyr 
            20                  25                  30          


Ile Pro Glu Pro Gly Ser Ser Cys Arg Gln Gln Glu Tyr Tyr Asn Gln 
        35                  40                  45              


Lys Ile Gln Met Cys Cys Ser Lys Cys Pro Pro Gly Tyr Arg Val Gln 
    50                  55                  60                  


Ser Leu Cys Asn Met Thr Leu Asp Thr Ile Cys Ala Ser Cys Glu Ser 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Leu Val Thr Ala Cys Phe Ser Cys 
                85                  90                  95      


Asn Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Thr 
            100                 105                 110         


Lys Gln Asn Arg Ile Cys Thr Cys Lys Pro Gly Trp Tyr Cys Thr Leu 
        115                 120                 125             


Gly Arg Gln Glu Gly Cys Arg Leu Cys Val Ala Leu Arg Lys Cys Gly 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Lys Pro Gly Thr Ala Thr Thr Asn Val Ile 
145                 150                 155                 160 


Cys Ala Pro Cys Gly Pro Gly Thr Phe Ser Asp Thr Thr Ser Tyr Thr 
                165                 170                 175     


Asp Thr Cys Lys Pro His Arg Asn Cys Ser Ser Val Ala Ile Pro Gly 
            180                 185                 190         


Thr Ala Ser Thr Asp Ala Val Cys Thr Ser Val Leu Pro Thr Arg Lys 
        195                 200                 205             


Val Ala Arg Gly Pro Ala Thr Thr Arg Ser Gln His Met Glu Pro Thr 
    210                 215                 220                 


Leu Gly Pro Ser Thr Ala Pro Ser Thr Phe Phe Leu Leu Pro Lys Val 
225                 230                 235                 240 


Pro Ser Pro Pro Ser Ser Pro Val Glu Gln Pro Asn Thr Gly Asn Ile 
                245                 250                 255     


Ser Leu Pro Ile Glu Leu Ile Val Gly Val Thr Ala Leu Gly Leu Leu 
            260                 265                 270         


Leu Ile Val Val Val Asn Cys Val Ile Met Thr Gln Lys Lys Lys Lys 
        275                 280                 285             


Pro Phe Cys Leu Gln Gly Asp Ala Lys Val Pro His Leu Pro Ala Asn 
    290                 295                 300                 


Lys Ala Gln Gly Ala Pro Gly Pro Glu Gln Gln His Leu Leu Thr Thr 
305                 310                 315                 320 


Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Thr Ser Ser Thr 
                325                 330                 335     


Asp Lys Arg Ala Pro Thr Arg Ser Gln Leu Gln Ser Pro Gly Val Glu 
            340                 345                 350         


Lys Ala Ser Thr Ser Gly Glu Ala Gln Thr Gly Cys Ser Ser Ser Glu 
        355                 360                 365             


Ala Ser Ser Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile Val 
    370                 375                 380                 


Asn Val Cys Ser Gly Pro Asp His Ser Ser Gln Cys Pro Ser Gln Ala 
385                 390                 395                 400 


Gly Ser Thr Arg Asp Thr Asp Ala Ser Thr Pro Asn Ser Pro Lys Glu 
                405                 410                 415     


Glu Gln Val Pro Phe Ser Lys Glu Glu Arg Pro Phe Gln Ser Gln Pro 
            420                 425                 430         


Gly Ala Pro Glu Thr Leu Leu Gln Gly Leu Glu Glu Lys Pro Leu Pro 
        435                 440                 445             


Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is any amino acid

<400>  35

Xaa Arg Xaa Asp Gly Xaa Ser Xaa Tyr Xaa Xaa Phe Asp Xaa 
1               5                   10                  


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  Xaa is any amino acid

<400>  36

Xaa Arg Xaa Asp Gly Ser Tyr Xaa Xaa Phe Asp Xaa Xaa Xaa 
1               5                   10                  


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Arg, Lys, or His

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Asn, Gln, Ser, or Thr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<400>  37

Gln Xaa Val Xaa Xaa Tyr Xaa Ser Xaa Trp Tyr Xaa Xaa Xaa 
1               5                   10                  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Lys, Arg, or His

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asn, Gln, Ser, or Thr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<400>  38

Ala Xaa Asp Xaa Xaa Xaa Xaa Ser Pro Xaa Xaa Xaa Trp Gly 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  39

Gln Arg Val Asp Gly Tyr Ser Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  40

Ala Arg Asp Asp Gly Ser Tyr Ser Pro Phe Asp Tyr Trp Gly 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  41

Ala Arg Asp Asp Gly Ser Tyr Ser Pro Phe Asp Tyr Phe Gly 
1               5                   10                  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any amino acid

<400>  42

Gly Xaa Thr Phe Xaa Xaa Tyr Xaa 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Asn, Gln, Ser, or Thr

<400>  43

Val Asp Pro Glu Tyr Xaa Xaa Thr 
1               5               


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<400>  44

Gln Asn Ile Asn Lys Xaa 
1               5       


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asn, Gln, Ser, or Thr

<400>  45

Cys Leu Gln Xaa Val Asn Leu Xaa Xaa 
1               5                   


<210>  46
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  46

Gly Tyr Thr Phe Thr Asp Tyr Leu 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  47

Val Asp Pro Glu Tyr Gly Ser Thr 
1               5               


<210>  48
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  48

Gln Asn Ile Asn Lys Tyr 
1               5       


<210>  49
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu or Ile

<400>  49

Cys Leu Gln Tyr Val Asn Leu Xaa Thr 
1               5                   


<210>  50
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is any amino acid

<400>  50

Gly Xaa Thr Phe Xaa Xaa Tyr 
1               5           


<210>  51
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any amino acid

<400>  51

Gly Xaa Thr Phe Xaa Xaa Tyr Xaa 
1               5               


<210>  52
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Asn, Gln, Ser, or Thr

<400>  52

Ser Ser Gly Xaa Xaa Tyr 
1               5       


<210>  53
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<400>  53

Ser Ala Ser Ser Ser Val Tyr Tyr Met Xaa 
1               5                   10  


<210>  54
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Asn, Gln, Ser, or Thr

<400>  54

Ser Thr Ser Asn Leu Ala Xaa 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ala, Val, Leu, Ile, Pro, Met, Trp, Phe, or Tyr

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Asn, Gln, Ser, or Thr

<400>  55

Gln Gln Arg Arg Asn Xaa Pro Tyr Xaa 
1               5                   


<210>  56
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  56

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  57
<211>  8
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu or Ile

<400>  57

Gly Tyr Thr Phe Thr Asp Tyr Xaa 
1               5               


<210>  58
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  58

Ser Ser Gly Gly Ser Tyr 
1               5       


<210>  59
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  59

Ser Ala Ser Ser Ser Val Tyr Tyr Met Tyr 
1               5                   10  


<210>  60
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  60

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  61

Gln Gln Arg Arg Asn Tyr Pro Tyr Thr 
1               5                   


<210>  62
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  62

Gly Tyr Thr Phe Thr Asp Tyr Ile 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  63

Gly Tyr Thr Phe Thr Asp Val Ile 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  64

Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               


<210>  65
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  65

Cys Leu Gln Tyr Val Asn Leu Leu Thr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  66

Cys Leu Gln Tyr Val Asn Leu Ile Thr 
1               5                   


<210>  67
<211>  4
<212>  PRT
<213>  Mus musculus

<400>  67

Leu Leu Ile Arg 
1               


<210>  68
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  68

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Arg Val Asp Gly Tyr Ser Ser Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser 
        115                 120             


<210>  69
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  69

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Tyr Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Arg Asn Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105             


