                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  METHODS TO PREVENT TERATOGENICITY OF IMID LIKE MOLECULES AND IMID
        BASED DEGRADERS/PROTACS

<130>  D0504.70143WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/672,441
<151>  2018-05-16

<150>  US 62/584,015
<151>  2017-11-09

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  1053
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Arg Arg Lys Gln Ala Lys Pro Gln His Ile Asn Ser Glu Glu 
1               5                   10                  15      


Asp Gln Gly Glu Gln Gln Pro Gln Gln Gln Thr Pro Glu Phe Ala Asp 
            20                  25                  30          


Ala Ala Pro Ala Ala Pro Ala Ala Gly Glu Leu Gly Ala Pro Val Asn 
        35                  40                  45              


His Pro Gly Asn Asp Glu Val Ala Ser Glu Asp Glu Ala Thr Val Lys 
    50                  55                  60                  


Arg Leu Arg Arg Glu Glu Thr His Val Cys Glu Lys Cys Cys Ala Glu 
65                  70                  75                  80  


Phe Phe Ser Ile Ser Glu Phe Leu Glu His Lys Lys Asn Cys Thr Lys 
                85                  90                  95      


Asn Pro Pro Val Leu Ile Met Asn Asp Ser Glu Gly Pro Val Pro Ser 
            100                 105                 110         


Glu Asp Phe Ser Gly Ala Val Leu Ser His Gln Pro Thr Ser Pro Gly 
        115                 120                 125             


Ser Lys Asp Cys His Arg Glu Asn Gly Gly Ser Ser Glu Asp Met Lys 
    130                 135                 140                 


Glu Lys Pro Asp Ala Glu Ser Val Val Tyr Leu Lys Thr Glu Thr Ala 
145                 150                 155                 160 


Leu Pro Pro Thr Pro Gln Asp Ile Ser Tyr Leu Ala Lys Gly Lys Val 
                165                 170                 175     


Ala Asn Thr Asn Val Thr Leu Gln Ala Leu Arg Gly Thr Lys Val Ala 
            180                 185                 190         


Val Asn Gln Arg Ser Ala Asp Ala Leu Pro Ala Pro Val Pro Gly Ala 
        195                 200                 205             


Asn Ser Ile Pro Trp Val Leu Glu Gln Ile Leu Cys Leu Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gln Ile Gln Leu Thr Glu Gln Ile Arg Ile Gln Val Asn 
225                 230                 235                 240 


Met Trp Ala Ser His Ala Leu His Ser Ser Gly Ala Gly Ala Asp Thr 
                245                 250                 255     


Leu Lys Thr Leu Gly Ser His Met Ser Gln Gln Val Ser Ala Ala Val 
            260                 265                 270         


Ala Leu Leu Ser Gln Lys Ala Gly Ser Gln Gly Leu Ser Leu Asp Ala 
        275                 280                 285             


Leu Lys Gln Ala Lys Leu Pro His Ala Asn Ile Pro Ser Ala Thr Ser 
    290                 295                 300                 


Ser Leu Ser Pro Gly Leu Ala Pro Phe Thr Leu Lys Pro Asp Gly Thr 
305                 310                 315                 320 


Arg Val Leu Pro Asn Val Met Ser Arg Leu Pro Ser Ala Leu Leu Pro 
                325                 330                 335     


Gln Ala Pro Gly Ser Val Leu Phe Gln Ser Pro Phe Ser Thr Val Ala 
            340                 345                 350         


Leu Asp Thr Ser Lys Lys Gly Lys Gly Lys Pro Pro Asn Ile Ser Ala 
        355                 360                 365             


Val Asp Val Lys Pro Lys Asp Glu Ala Ala Leu Tyr Lys His Lys Cys 
    370                 375                 380                 


Lys Tyr Cys Ser Lys Val Phe Gly Thr Asp Ser Ser Leu Gln Ile His 
385                 390                 395                 400 


Leu Arg Ser His Thr Gly Glu Arg Pro Phe Val Cys Ser Val Cys Gly 
                405                 410                 415     


His Arg Phe Thr Thr Lys Gly Asn Leu Lys Val His Phe His Arg His 
            420                 425                 430         


Pro Gln Val Lys Ala Asn Pro Gln Leu Phe Ala Glu Phe Gln Asp Lys 
        435                 440                 445             


Val Ala Ala Gly Asn Gly Ile Pro Tyr Ala Leu Ser Val Pro Asp Pro 
    450                 455                 460                 


Ile Asp Glu Pro Ser Leu Ser Leu Asp Ser Lys Pro Val Leu Val Thr 
465                 470                 475                 480 


Thr Ser Val Gly Leu Pro Gln Asn Leu Ser Ser Gly Thr Asn Pro Lys 
                485                 490                 495     


Asp Leu Thr Gly Gly Ser Leu Pro Gly Asp Leu Gln Pro Gly Pro Ser 
            500                 505                 510         


Pro Glu Ser Glu Gly Gly Pro Thr Leu Pro Gly Val Gly Pro Asn Tyr 
        515                 520                 525             


Asn Ser Pro Arg Ala Gly Gly Phe Gln Gly Ser Gly Thr Pro Glu Pro 
    530                 535                 540                 


Gly Ser Glu Thr Leu Lys Leu Gln Gln Leu Val Glu Asn Ile Asp Lys 
545                 550                 555                 560 


Ala Thr Thr Asp Pro Asn Glu Cys Leu Ile Cys His Arg Val Leu Ser 
                565                 570                 575     


Cys Gln Ser Ser Leu Lys Met His Tyr Arg Thr His Thr Gly Glu Arg 
            580                 585                 590         


Pro Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn 
        595                 600                 605             


Leu Lys Thr His Leu Gly Val His Arg Thr Asn Thr Ser Ile Lys Thr 
    610                 615                 620                 


Gln His Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val Met 
625                 630                 635                 640 


Leu Gln Gln His Ile Arg Met His Met Gly Gly Gln Ile Pro Asn Thr 
                645                 650                 655     


Pro Leu Pro Glu Asn Pro Cys Asp Phe Thr Gly Ser Glu Pro Met Thr 
            660                 665                 670         


Val Gly Glu Asn Gly Ser Thr Gly Ala Ile Cys His Asp Asp Val Ile 
        675                 680                 685             


Glu Ser Ile Asp Val Glu Glu Val Ser Ser Gln Glu Ala Pro Ser Ser 
    690                 695                 700                 


Ser Ser Lys Val Pro Thr Pro Leu Pro Ser Ile His Ser Ala Ser Pro 
705                 710                 715                 720 


Thr Leu Gly Phe Ala Met Met Ala Ser Leu Asp Ala Pro Gly Lys Val 
                725                 730                 735     


Gly Pro Ala Pro Phe Asn Leu Gln Arg Gln Gly Ser Arg Glu Asn Gly 
            740                 745                 750         


Ser Val Glu Ser Asp Gly Leu Thr Asn Asp Ser Ser Ser Leu Met Gly 
        755                 760                 765             


Asp Gln Glu Tyr Gln Ser Arg Ser Pro Asp Ile Leu Glu Thr Thr Ser 
    770                 775                 780                 


Phe Gln Ala Leu Ser Pro Ala Asn Ser Gln Ala Glu Ser Ile Lys Ser 
785                 790                 795                 800 


Lys Ser Pro Asp Ala Gly Ser Lys Ala Glu Ser Ser Glu Asn Ser Arg 
                805                 810                 815     


Thr Glu Met Glu Gly Arg Ser Ser Leu Pro Ser Thr Phe Ile Arg Ala 
            820                 825                 830         


Pro Pro Thr Tyr Val Lys Val Glu Val Pro Gly Thr Phe Val Gly Pro 
        835                 840                 845             


Ser Thr Leu Ser Pro Gly Met Thr Pro Leu Leu Ala Ala Gln Pro Arg 
    850                 855                 860                 


Arg Gln Ala Lys Gln His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser 
865                 870                 875                 880 


Ser Ala Ser Ala Leu Gln Ile His Glu Arg Thr His Thr Gly Glu Lys 
                885                 890                 895     


Pro Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn 
            900                 905                 910         


Leu Lys Val His Tyr Met Thr His Gly Ala Asn Asn Asn Ser Ala Arg 
        915                 920                 925             


Arg Gly Arg Lys Leu Ala Ile Glu Asn Thr Met Ala Leu Leu Gly Thr 
    930                 935                 940                 


Asp Gly Lys Arg Val Ser Glu Ile Phe Pro Lys Glu Ile Leu Ala Pro 
945                 950                 955                 960 


Ser Val Asn Val Asp Pro Val Val Trp Asn Gln Tyr Thr Ser Met Leu 
                965                 970                 975     


Asn Gly Gly Leu Ala Val Lys Thr Asn Glu Ile Ser Val Ile Gln Ser 
            980                 985                 990         


Gly Gly Val Pro Thr Leu Pro Val  Ser Leu Gly Ala Thr  Ser Val Val 
        995                 1000                 1005             


Asn Asn  Ala Thr Val Ser Lys  Met Asp Gly Ser Gln  Ser Gly Ile 
    1010                 1015                 1020             


Ser Ala  Asp Val Glu Lys Pro  Ser Ala Thr Asp Gly  Val Pro Lys 
    1025                 1030                 1035             


His Gln  Phe Pro His Phe Leu  Glu Glu Asn Lys Ile  Ala Val Ser 
    1040                 1045                 1050             


<210>  2
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Glu Gly Asp Gln Gln Asp Ala Ala His Asn Met Gly Asn 
1               5                   10                  15      


His Leu Pro Leu Leu Pro Ala Glu Ser Glu Glu Glu Asp Glu Met Glu 
            20                  25                  30          


Val Glu Asp Gln Asp Ser Lys Glu Ala Lys Lys Pro Asn Ile Ile Asn 
        35                  40                  45              


Phe Asp Thr Ser Leu Pro Thr Ser His Thr Tyr Leu Gly Ala Asp Met 
    50                  55                  60                  


Glu Glu Phe His Gly Arg Thr Leu His Asp Asp Asp Ser Cys Gln Val 
65                  70                  75                  80  


Ile Pro Val Leu Pro Gln Val Met Met Ile Leu Ile Pro Gly Gln Thr 
                85                  90                  95      


Leu Pro Leu Gln Leu Phe His Pro Gln Glu Val Ser Met Val Arg Asn 
            100                 105                 110         


Leu Ile Gln Lys Asp Arg Thr Phe Ala Val Leu Ala Tyr Ser Asn Val 
        115                 120                 125             


Gln Glu Arg Glu Ala Gln Phe Gly Thr Thr Ala Glu Ile Tyr Ala Tyr 
    130                 135                 140                 


Arg Glu Glu Gln Asp Phe Gly Ile Glu Ile Val Lys Val Lys Ala Ile 
145                 150                 155                 160 


Gly Arg Gln Arg Phe Lys Val Leu Glu Leu Arg Thr Gln Ser Asp Gly 
                165                 170                 175     


Ile Gln Gln Ala Lys Val Gln Ile Leu Pro Glu Cys Val Leu Pro Ser 
            180                 185                 190         


Thr Met Ser Ala Val Gln Leu Glu Ser Leu Asn Lys Cys Gln Ile Phe 
        195                 200                 205             


Pro Ser Lys Pro Val Ser Arg Glu Asp Gln Cys Ser Tyr Lys Trp Trp 
    210                 215                 220                 


Gln Lys Tyr Gln Lys Arg Lys Phe His Cys Ala Asn Leu Thr Ser Trp 
225                 230                 235                 240 


Pro Arg Trp Leu Tyr Ser Leu Tyr Asp Ala Glu Thr Leu Met Asp Arg 
                245                 250                 255     


Ile Lys Lys Gln Leu Arg Glu Trp Asp Glu Asn Leu Lys Asp Asp Ser 
            260                 265                 270         


Leu Pro Ser Asn Pro Ile Asp Phe Ser Tyr Arg Val Ala Ala Cys Leu 
        275                 280                 285             


Pro Ile Asp Asp Val Leu Arg Ile Gln Leu Leu Lys Ile Gly Ser Ala 
    290                 295                 300                 


Ile Gln Arg Leu Arg Cys Glu Leu Asp Ile Met Asn Lys Cys Thr Ser 
305                 310                 315                 320 


Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys Asn Glu 
                325                 330                 335     


Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val Asn Pro 
            340                 345                 350         


His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys Asn Leu 
        355                 360                 365             


Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly Tyr 
    370                 375                 380                 


Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly Trp 
385                 390                 395                 400 


Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe Trp Gly 
                405                 410                 415     


Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro Asp Thr Glu Asp Glu 
            420                 425                 430         


Ile Ser Pro Asp Lys Val Ile Leu Cys Leu 
        435                 440         


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
aagtactgta acaaggtttt tg                                                22


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
acacttgtgc ttgtagag                                                     18


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
tctgtctgtg ctcatcgctt cac                                               23


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
gcacacgaag ggtctctc                                                     18


<210>  7
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
ctctgtctgt aatcatcgct tcaccac                                           27


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
cacacgaagg gtctctct                                                     18


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
aagatctgtg cccgagcctt ttc                                               23


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
acactggaac ggtctctc                                                     18


<210>  11
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
taagatctgt aaccgagcct tttctac                                           27


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
cactggaacg gtctctcc                                                     18


<210>  13
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
agggcaatct caaggtccac tttcaccgac accctcaggt gaaggcaaac cccc             54


<210>  14
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
tggtggtgaa gcggtgacca cagacagagc acacgaaagg tctctctccg gtgtg            55


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
ggtcctcgag cagatcttgt                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
ggcatccaga gacagacctt                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
gaaggtgaag gtcggagtc                                                    19


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
gaagatggtg atgggatttc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
tgcgggtaaa cagacatggc                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
cctcctccga gttgatgtgc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
accccagcac atcaactcgg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
ccagcacatc aactcggagg                                                   20


<210>  23
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His 
            20              


<210>  24
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Met Lys Lys His 
            20              


<210>  25
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Phe Val Cys Ser Val Cys Gly His Arg Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Phe His Arg His 
            20              


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Phe Gln Cys Lys Ile Cys Gly Arg Ala Phe Ser Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Thr His Leu Gly Val His 
            20              


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly 
1               5                   10                  15      


Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly 
            20                  25                  30          


Trp 
    


<210>  28
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly 
1               5                   10                  15      


Tyr Ala Trp Thr Val Ala Gln Cys Arg Ile Cys Ala Ser His Ile Gly 
            20                  25                  30          


Trp 
    


<210>  29
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Leu Asn Leu Ile Gly Arg Pro Ser Thr Val His Ser Trp Phe Pro Gly 
1               5                   10                  15      


Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile Gly 
            20                  25                  30          


Trp 
    


<210>  30
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Leu Asn Leu Ser Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro Gly 
1               5                   10                  15      


Tyr Ala Trp Thr Ile Ala Gln Cys Arg Ile Cys Gly Asn His Met Gly 
            20                  25                  30          


Trp 
    


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Leu Asn Leu Ile Gly Arg Pro Ser Thr Leu His Ser Trp Phe Pro Gly 
1               5                   10                  15      


Tyr Ala Trp Thr Ile Ala Gln Cys Arg Thr Cys Ser Ser His Met Gly 
            20                  25                  30          


Trp 
    


<210>  32
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Tyr Val Cys Pro Ile Cys Gly His Arg Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Leu Gln Arg His 
            20              


<210>  33
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Tyr Val Cys Pro Val Cys Gly His Arg Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Phe His Arg His 
            20              


<210>  34
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Phe Lys Cys Asn Ile Cys Gly Asn Arg Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Phe Gln Arg His 
            20              


<210>  35
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Tyr Lys Cys Asn Ile Cys Gly Asn Arg Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Phe Gln Arg His 
            20              


<210>  36
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile Ser Phe Asn Val Leu 
1               5                   10                  15      


Met Val His Lys Arg Ser His 
            20              


<210>  37
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly Pro Asn Val Leu 
1               5                   10                  15      


Met Val His Lys Arg Ser His 
            20              


<210>  38
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Tyr Lys Cys Glu Phe Cys Gly Arg Ser Tyr Lys Gln Arg Ser Ser Leu 
1               5                   10                  15      


Glu Glu His Lys Glu Arg Cys 
            20              


<210>  39
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

His Lys Cys Gly Tyr Cys Gly Arg Ser Tyr Lys Gln Arg Ser Ser Leu 
1               5                   10                  15      


Glu Glu His Lys Glu Arg Cys His 
            20                  


<210>  40
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Gln Arg Lys His 
            20              


<210>  41
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Leu Gln Cys Glu Ile Cys Gly Tyr Gln Cys Arg Gln Arg Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Met Lys Lys His 
            20              


<210>  42
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Tyr Arg Cys Asp Thr Cys Gly Gln Thr Phe Ala Asn Arg Cys Asn Leu 
1               5                   10                  15      


Lys Ser His Gln Arg His Val His 
            20                  


<210>  43
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Tyr Arg Cys Thr Val Cys Gly His Tyr Ser Ser Thr Leu Asn Leu Met 
1               5                   10                  15      


Ser Lys His Val Gly Val His 
            20              


<210>  44
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Met Arg Cys Asp Phe Cys Gly Ala Gly Phe Asp Thr Arg Ala Gly Leu 
1               5                   10                  15      


Ser Ser His Ala Arg Ala His 
            20              


<210>  45
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Thr Thr Cys Glu Val Cys Gly Ala Cys Phe Glu Thr Arg Lys Gly Leu 
1               5                   10                  15      


Ser Ser His Ala Arg Ser His 
            20              


<210>  46
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  46

Tyr Ser Cys His Val Cys Gly Phe Glu Thr Glu Leu Asn Val Gln Phe 
1               5                   10                  15      


Val Ser His Met Ser Leu His 
            20              


<210>  47
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Tyr Ser Cys Lys Val Cys Gly Lys Arg Phe Ala His Thr Ser Glu Phe 
1               5                   10                  15      


Asn Tyr His Arg Arg Ile His 
            20              


<210>  48
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  48

Tyr Gly Cys Thr Glu Cys Gly Ala Arg Phe Ser Gln Pro Ser Ala Leu 
1               5                   10                  15      


Lys Thr His Met Arg Ile His 
            20              


<210>  49
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  49

Phe Val Cys Asp Glu Cys Gly Ala Arg Phe Thr Gln Asn His Met Leu 
1               5                   10                  15      


Ile Tyr His Lys Arg Cys His 
            20              


<210>  50
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  50

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Arg Leu Ser His Leu 
1               5                   10                  15      


Thr Thr His Lys Ile Ile His 
            20              


<210>  51
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  51

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Arg Leu Ser His Leu 
1               5                   10                  15      


Thr Thr His Lys Arg Ile His 
            20              


<210>  52
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  52

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Thr Leu 
1               5                   10                  15      


Thr Thr His Lys Ile Ile His 
            20              


<210>  53
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  53

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Lys Gln Ser Ser Thr Leu 
1               5                   10                  15      


Thr Thr His Lys Arg Ile His 
            20              


<210>  54
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  54

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Leu Ser Ser Gln Leu 
1               5                   10                  15      


Thr Thr His Lys Ile Ile His 
            20              


<210>  55
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  55

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser His Leu 
1               5                   10                  15      


Thr Thr His Lys Met Ile His 
            20              


<210>  56
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ala Asn Leu 
1               5                   10                  15      


Thr Thr His Lys Arg Ile His 
            20              


<210>  57
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  57

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Gln Ser Ser Thr Leu 
1               5                   10                  15      


Ser Lys His Lys Val Ile His 
            20              


<210>  58
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  58

Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Asn Ser Ser Ile Leu 
1               5                   10                  15      


Asn Arg His Lys Met Ile His 
            20              


<210>  59
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  59

Tyr Lys Cys Lys Glu Cys Gly Lys Ala Tyr Asn Glu Ala Ser Asn Leu 
1               5                   10                  15      


Ser Thr His Lys Arg Ile His 
            20              


<210>  60
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  60

Leu Ala Cys Gly Glu Cys Gly Trp Ala Phe Ala Asp Pro Thr Ala Leu 
1               5                   10                  15      


Glu Gln His Arg Gln Leu His 
            20              


<210>  61
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  61

His Arg Cys Gly Gln Cys Gly Lys Gly Leu Ser Ser Lys Thr Ala Leu 
1               5                   10                  15      


Arg Leu His Glu Arg Thr His 
            20              


<210>  62
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  62

His Gly Cys Thr Arg Cys Gly Lys Asn Phe Ser Ser Ala Ser Ala Leu 
1               5                   10                  15      


Gln Ile His Glu Arg Thr His 
            20              


<210>  63
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  63

Tyr Cys Cys Asp Gln Cys Gly Lys Gln Phe Thr Gln Leu Asn Ala Leu 
1               5                   10                  15      


Gln Arg His Arg Arg Ile His 
            20              


<210>  64
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His 
            20              


<210>  65
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  65

Phe Val Cys Asn Ile Cys Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu 
1               5                   10                  15      


Lys Val His Tyr Met Thr His 
            20              


<210>  66
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  66

Phe Thr Cys Asp Arg Cys Gly Lys Arg Phe Glu Lys Leu Asp Ser Val 
1               5                   10                  15      


Lys Phe His Thr Leu Lys Ser His 
            20                  


<210>  67
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  67

Phe Pro Cys Glu Phe Cys Gly Lys Arg Phe Glu Lys Pro Asp Ser Val 
1               5                   10                  15      


Ala Ala His Arg Ser Lys Ser His 
            20                  


<210>  68
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  68

Phe Ser Cys Asn Ile Cys Gly Lys Lys Phe Glu Lys Lys Asp Ser Val 
1               5                   10                  15      


Val Ala His Lys Ala Lys Ser His 
            20                  


<210>  69
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  69

Phe Pro Cys Glu Leu Cys Gly Lys Lys Phe Lys Arg Lys Lys Asp Val 
1               5                   10                  15      


Lys Arg His Val Leu Gln Val His 
            20                  


<210>  70
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  70

Phe Met Cys Asn Ala Cys Gly Arg Thr Phe Thr Asp Lys Ser Thr Leu 
1               5                   10                  15      


Arg Arg His Thr Ser Ile His 
            20              


<210>  71
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  71

Phe Gln Cys Pro Ile Cys Gly Leu Val Ile Lys Arg Lys Ser Tyr Trp 
1               5                   10                  15      


Lys Arg His Met Val Ile His 
            20              


<210>  72
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  72

Phe Pro Cys Asp Val Cys Gly Lys Val Phe Gly Arg Gln Gln Thr Leu 
1               5                   10                  15      


Ser Arg His Leu Ser Leu His 
            20              


<210>  73
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  73

Phe Met Cys Glu Thr Cys Gly Lys Ser Phe Ala Ser Lys Glu Tyr Leu 
1               5                   10                  15      


Lys His His Asn Arg Ile His 
            20              


<210>  74
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  74

Phe Thr Cys Glu Thr Cys Gly Lys Ser Phe Lys Arg Lys Asn His Leu 
1               5                   10                  15      


Glu Val His Arg Arg Thr His 
            20              


<210>  75
<211>  1140
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ser Tyr Asn Tyr Val Val Thr Ala Gln Lys Pro Thr Ala Val Asn 
1               5                   10                  15      


Gly Cys Val Thr Gly His Phe Thr Ser Ala Glu Asp Leu Asn Leu Leu 
            20                  25                  30          


Ile Ala Lys Asn Thr Arg Leu Glu Ile Tyr Val Val Thr Ala Glu Gly 
        35                  40                  45              


Leu Arg Pro Val Lys Glu Val Gly Met Tyr Gly Lys Ile Ala Val Met 
    50                  55                  60                  


Glu Leu Phe Arg Pro Lys Gly Glu Ser Lys Asp Leu Leu Phe Ile Leu 
65                  70                  75                  80  


Thr Ala Lys Tyr Asn Ala Cys Ile Leu Glu Tyr Lys Gln Ser Gly Glu 
                85                  90                  95      


Ser Ile Asp Ile Ile Thr Arg Ala His Gly Asn Val Gln Asp Arg Ile 
            100                 105                 110         


Gly Arg Pro Ser Glu Thr Gly Ile Ile Gly Ile Ile Asp Pro Glu Cys 
        115                 120                 125             


Arg Met Ile Gly Leu Arg Leu Tyr Asp Gly Leu Phe Lys Val Ile Pro 
    130                 135                 140                 


Leu Asp Arg Asp Asn Lys Glu Leu Lys Ala Phe Asn Ile Arg Leu Glu 
145                 150                 155                 160 


Glu Leu His Val Ile Asp Val Lys Phe Leu Tyr Gly Cys Gln Ala Pro 
                165                 170                 175     


Thr Ile Cys Phe Val Tyr Gln Asp Pro Gln Gly Arg His Val Lys Thr 
            180                 185                 190         


Tyr Glu Val Ser Leu Arg Glu Lys Glu Phe Asn Lys Gly Pro Trp Lys 
        195                 200                 205             


Gln Glu Asn Val Glu Ala Glu Ala Ser Met Val Ile Ala Val Pro Glu 
    210                 215                 220                 


Pro Phe Gly Gly Ala Ile Ile Ile Gly Gln Glu Ser Ile Thr Tyr His 
225                 230                 235                 240 


Asn Gly Asp Lys Tyr Leu Ala Ile Ala Pro Pro Ile Ile Lys Gln Ser 
                245                 250                 255     


Thr Ile Val Cys His Asn Arg Val Asp Pro Asn Gly Ser Arg Tyr Leu 
            260                 265                 270         


Leu Gly Asp Met Glu Gly Arg Leu Phe Met Leu Leu Leu Glu Lys Glu 
        275                 280                 285             


Glu Gln Met Asp Gly Thr Val Thr Leu Lys Asp Leu Arg Val Glu Leu 
    290                 295                 300                 


Leu Gly Glu Thr Ser Ile Ala Glu Cys Leu Thr Tyr Leu Asp Asn Gly 
305                 310                 315                 320 


Val Val Phe Val Gly Ser Arg Leu Gly Asp Ser Gln Leu Val Lys Leu 
                325                 330                 335     


Asn Val Asp Ser Asn Glu Gln Gly Ser Tyr Val Val Ala Met Glu Thr 
            340                 345                 350         


Phe Thr Asn Leu Gly Pro Ile Val Asp Met Cys Val Val Asp Leu Glu 
        355                 360                 365             


Arg Gln Gly Gln Gly Gln Leu Val Thr Cys Ser Gly Ala Phe Lys Glu 
    370                 375                 380                 


Gly Ser Leu Arg Ile Ile Arg Asn Gly Ile Gly Ile His Glu His Ala 
385                 390                 395                 400 


Ser Ile Asp Leu Pro Gly Ile Lys Gly Leu Trp Pro Leu Arg Ser Asp 
                405                 410                 415     


Pro Asn Arg Glu Thr Asp Asp Thr Leu Val Leu Ser Phe Val Gly Gln 
            420                 425                 430         


Thr Arg Val Leu Met Leu Asn Gly Glu Glu Val Glu Glu Thr Glu Leu 
        435                 440                 445             


Met Gly Phe Val Asp Asp Gln Gln Thr Phe Phe Cys Gly Asn Val Ala 
    450                 455                 460                 


His Gln Gln Leu Ile Gln Ile Thr Ser Ala Ser Val Arg Leu Val Ser 
465                 470                 475                 480 


Gln Glu Pro Lys Ala Leu Val Ser Glu Trp Lys Glu Pro Gln Ala Lys 
                485                 490                 495     


Asn Ile Ser Val Ala Ser Cys Asn Ser Ser Gln Val Val Val Ala Val 
            500                 505                 510         


Gly Arg Ala Leu Tyr Tyr Leu Gln Ile His Pro Gln Glu Leu Arg Gln 
        515                 520                 525             


Ile Ser His Thr Glu Met Glu His Glu Val Ala Cys Leu Asp Ile Thr 
    530                 535                 540                 


Pro Leu Gly Asp Ser Asn Gly Leu Ser Pro Leu Cys Ala Ile Gly Leu 
545                 550                 555                 560 


Trp Thr Asp Ile Ser Ala Arg Ile Leu Lys Leu Pro Ser Phe Glu Leu 
                565                 570                 575     


Leu His Lys Glu Met Leu Gly Gly Glu Ile Ile Pro Arg Ser Ile Leu 
            580                 585                 590         


Met Thr Thr Phe Glu Ser Ser His Tyr Leu Leu Cys Ala Leu Gly Asp 
        595                 600                 605             


Gly Ala Leu Phe Tyr Phe Gly Leu Asn Ile Glu Thr Gly Leu Leu Ser 
    610                 615                 620                 


Asp Arg Lys Lys Val Thr Leu Gly Thr Gln Pro Thr Val Leu Arg Thr 
625                 630                 635                 640 


Phe Arg Ser Leu Ser Thr Thr Asn Val Phe Ala Cys Ser Asp Arg Pro 
                645                 650                 655     


Thr Val Ile Tyr Ser Ser Asn His Lys Leu Val Phe Ser Asn Val Asn 
            660                 665                 670         


Leu Lys Glu Val Asn Tyr Met Cys Pro Leu Asn Ser Asp Gly Tyr Pro 
        675                 680                 685             


Asp Ser Leu Ala Leu Ala Asn Asn Ser Thr Leu Thr Ile Gly Thr Ile 
    690                 695                 700                 


Asp Glu Ile Gln Lys Leu His Ile Arg Thr Val Pro Leu Tyr Glu Ser 
705                 710                 715                 720 


Pro Arg Lys Ile Cys Tyr Gln Glu Val Ser Gln Cys Phe Gly Val Leu 
                725                 730                 735     


Ser Ser Arg Ile Glu Val Gln Asp Thr Ser Gly Gly Thr Thr Ala Leu 
            740                 745                 750         


Arg Pro Ser Ala Ser Thr Gln Ala Leu Ser Ser Ser Val Ser Ser Ser 
        755                 760                 765             


Lys Leu Phe Ser Ser Ser Thr Ala Pro His Glu Thr Ser Phe Gly Glu 
    770                 775                 780                 


Glu Val Glu Val His Asn Leu Leu Ile Ile Asp Gln His Thr Phe Glu 
785                 790                 795                 800 


Val Leu His Ala His Gln Phe Leu Gln Asn Glu Tyr Ala Leu Ser Leu 
                805                 810                 815     


Val Ser Cys Lys Leu Gly Lys Asp Pro Asn Thr Tyr Phe Ile Val Gly 
            820                 825                 830         


Thr Ala Met Val Tyr Pro Glu Glu Ala Glu Pro Lys Gln Gly Arg Ile 
        835                 840                 845             


Val Val Phe Gln Tyr Ser Asp Gly Lys Leu Gln Thr Val Ala Glu Lys 
    850                 855                 860                 


Glu Val Lys Gly Ala Val Tyr Ser Met Val Glu Phe Asn Gly Lys Leu 
865                 870                 875                 880 


Leu Ala Ser Ile Asn Ser Thr Val Arg Leu Tyr Glu Trp Thr Thr Glu 
                885                 890                 895     


Lys Glu Leu Arg Thr Glu Cys Asn His Tyr Asn Asn Ile Met Ala Leu 
            900                 905                 910         


Tyr Leu Lys Thr Lys Gly Asp Phe Ile Leu Val Gly Asp Leu Met Arg 
        915                 920                 925             


Ser Val Leu Leu Leu Ala Tyr Lys Pro Met Glu Gly Asn Phe Glu Glu 
    930                 935                 940                 


Ile Ala Arg Asp Phe Asn Pro Asn Trp Met Ser Ala Val Glu Ile Leu 
945                 950                 955                 960 


Asp Asp Asp Asn Phe Leu Gly Ala Glu Asn Ala Phe Asn Leu Phe Val 
                965                 970                 975     


Cys Gln Lys Asp Ser Ala Ala Thr Thr Asp Glu Glu Arg Gln His Leu 
            980                 985                 990         


Gln Glu Val Gly Leu Phe His Leu  Gly Glu Phe Val Asn  Val Phe Cys 
        995                 1000                 1005             


His Gly  Ser Leu Val Met Gln  Asn Leu Gly Glu Thr  Ser Thr Pro 
    1010                 1015                 1020             


Thr Gln  Gly Ser Val Leu Phe  Gly Thr Val Asn Gly  Met Ile Gly 
    1025                 1030                 1035             


Leu Val  Thr Ser Leu Ser Glu  Ser Trp Tyr Asn Leu  Leu Leu Asp 
    1040                 1045                 1050             


Met Gln  Asn Arg Leu Asn Lys  Val Ile Lys Ser Val  Gly Lys Ile 
    1055                 1060                 1065             


Glu His  Ser Phe Trp Arg Ser  Phe His Thr Glu Arg  Lys Thr Glu 
    1070                 1075                 1080             


Pro Ala  Thr Gly Phe Ile Asp  Gly Asp Leu Ile Glu  Ser Phe Leu 
    1085                 1090                 1095             


Asp Ile  Ser Arg Pro Lys Met  Gln Glu Val Val Ala  Asn Leu Gln 
    1100                 1105                 1110             


Tyr Asp  Asp Gly Ser Gly Met  Lys Arg Glu Ala Thr  Ala Asp Asp 
    1115                 1120                 1125             


Leu Ile  Lys Val Val Glu Glu  Leu Thr Arg Ile His  
    1130                 1135                 1140 


