                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Isacoff, Ehud Y
 
<120>  COMPOSITIONS AND METHODS FOR ENHANCING VISUAL FUNCTION

<130>  BERK-366WO

<150>  62/585,237
<151>  2017-11-13

<150>  62/589,476
<151>  2017-11-21

<150>  62/641,783
<151>  2018-03-12

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Ile Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Val Val 
            100                 105                 110         


Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Thr Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Val Leu Ala Phe Cys Phe Cys Trp Gly Pro Tyr Ala Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Pro Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Phe Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  2
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  3
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val Pro 
305                 310 


<210>  4
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Thr Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Ile Val 
            100                 105                 110         


Asn Gln Val Ser Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Ile Pro Leu Ala Ile Ile Met Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Ile Phe Ala Tyr Cys Val Cys Trp Gly Pro Tyr Thr Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Ala Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Tyr Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  5
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Lys Met Ser Glu Glu Glu Phe Tyr Leu Phe Lys Asn Ile Ser 
1               5                   10                  15      


Ser Val Gly Pro Trp Asp Gly Pro Gln Tyr His Ile Ala Pro Val Trp 
            20                  25                  30          


Ala Phe Tyr Leu Gln Ala Ala Phe Met Gly Thr Val Phe Leu Ile Gly 
        35                  40                  45              


Phe Pro Leu Asn Ala Met Val Leu Val Ala Thr Leu Arg Tyr Lys Lys 
    50                  55                  60                  


Leu Arg Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly 
65                  70                  75                  80  


Phe Leu Leu Cys Ile Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys 
                85                  90                  95      


Asn Gly Tyr Phe Val Phe Gly Arg His Val Cys Ala Leu Glu Gly Phe 
            100                 105                 110         


Leu Gly Thr Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu 
        115                 120                 125             


Ala Phe Glu Arg Tyr Ile Val Ile Cys Lys Pro Phe Gly Asn Phe Arg 
    130                 135                 140                 


Phe Ser Ser Lys His Ala Leu Thr Val Val Leu Ala Thr Trp Thr Ile 
145                 150                 155                 160 


Gly Ile Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile 
                165                 170                 175     


Pro Glu Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly 
            180                 185                 190         


Thr Lys Tyr Arg Ser Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys 
        195                 200                 205             


Phe Ile Val Pro Leu Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu 
    210                 215                 220                 


Arg Ala Leu Lys Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr 
225                 230                 235                 240 


Gln Lys Ala Glu Arg Glu Val Ser Arg Met Val Val Val Met Val Gly 
                245                 250                 255     


Ser Phe Cys Val Cys Tyr Val Pro Tyr Ala Ala Phe Ala Met Tyr Met 
            260                 265                 270         


Val Asn Asn Arg Asn His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro 
        275                 280                 285             


Ser Phe Phe Ser Lys Ser Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys 
    290                 295                 300                 


Phe Met Asn Lys Gln Phe Gln Ala Cys Ile Met Lys Met Val Cys Gly 
305                 310                 315                 320 


Lys Ala Met Thr Asp Glu Ser Asp Thr Cys Ser Ser Gln Lys Thr Glu 
                325                 330                 335     


Val Ser Thr Val Ser Ser Thr Gln Val Gly Pro Asn 
            340                 345             


<210>  6
<211>  346
<212>  PRT
<213>  Mus Musculus

<400>  6

Met Ser Gly Glu Asp Asp Phe Tyr Leu Phe Gln Asn Ile Ser Ser Val 
1               5                   10                  15      


Gly Pro Trp Asp Gly Pro Gln Tyr His Leu Ala Pro Val Trp Ala Phe 
            20                  25                  30          


Arg Leu Gln Ala Ala Phe Met Gly Phe Val Phe Phe Val Gly Thr Pro 
        35                  40                  45              


Leu Asn Ala Ile Val Leu Val Ala Thr Leu His Tyr Lys Lys Leu Arg 
    50                  55                  60                  


Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Leu Gly Gly Phe Leu 
65                  70                  75                  80  


Phe Cys Ile Phe Ser Val Phe Thr Val Phe Ile Ala Ser Cys His Gly 
                85                  90                  95      


Tyr Phe Leu Phe Gly Arg His Val Cys Ala Leu Glu Ala Phe Leu Gly 
            100                 105                 110         


Ser Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu Ala Phe 
        115                 120                 125             


Glu Arg Tyr Val Val Ile Cys Lys Pro Phe Gly Ser Ile Arg Phe Asn 
    130                 135                 140                 


Ser Lys His Ala Leu Met Val Val Leu Ala Thr Trp Ile Ile Gly Ile 
145                 150                 155                 160 


Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile Pro Glu 
                165                 170                 175     


Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly Thr Lys 
            180                 185                 190         


Tyr Arg Ser Glu Tyr Tyr Thr Trp Phe Leu Phe Ile Phe Cys Phe Ile 
        195                 200                 205             


Ile Pro Leu Ser Leu Ile Cys Phe Ser Tyr Ser Gln Leu Leu Arg Thr 
    210                 215                 220                 


Leu Arg Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr Gln Lys 
225                 230                 235                 240 


Ala Glu Arg Glu Val Ser His Met Val Val Val Met Val Gly Ser Phe 
                245                 250                 255     


Cys Leu Cys Tyr Val Pro Tyr Ala Ala Leu Ala Met Tyr Met Val Asn 
            260                 265                 270         


Asn Arg Asn His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro Ala Phe 
        275                 280                 285             


Phe Ser Lys Ser Ser Cys Val Tyr Asn Pro Ile Ile Tyr Cys Phe Met 
    290                 295                 300                 


Asn Lys Gln Phe Arg Ala Cys Ile Leu Glu Met Val Cys Arg Lys Pro 
305                 310                 315                 320 


Met Ala Asp Glu Ser Asp Val Ser Gly Ser Gln Lys Thr Glu Val Ser 
                325                 330                 335     


Thr Val Ser Ser Ser Lys Val Gly Pro His 
            340                 345     


<210>  7
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Glu Asp Asp Phe Tyr Leu Phe Gln Asn Ile Ser Ser Val Gly Pro Trp 
1               5                   10                  15      


Asp Gly Pro Gln Tyr His Leu Ala Pro Val Trp Ala Phe Tyr Leu Gln 
            20                  25                  30          


Ala Ala Phe Met Gly Thr Val Phe Leu Ile Gly Phe Pro Leu Asn Ala 
        35                  40                  45              


Met Val Leu Val Ala Thr Leu His Tyr Lys Lys Leu Arg Gln Pro Leu 
    50                  55                  60                  


Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly Phe Leu Leu Cys Ile 
65                  70                  75                  80  


Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys Asn Gly Tyr Phe Val 
                85                  90                  95      


Phe Gly Arg His Val Cys Ala Leu Glu Gly Phe Leu Gly Thr Val Ala 
            100                 105                 110         


Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu Ala Phe Glu Arg Tyr 
        115                 120                 125             


Val Val Ile Cys Lys Pro Phe Gly Ser Ile Arg Phe Asn Ser Lys His 
    130                 135                 140                 


Ala Leu Thr Val Val Leu Ala Thr Trp Thr Ile Gly Ile Gly Val Ser 
145                 150                 155                 160 


Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile Pro Glu Gly Leu Gln 
                165                 170                 175     


Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly Thr Lys Tyr Arg Ser 
            180                 185                 190         


Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys Phe Ile Val Pro Leu 
        195                 200                 205             


Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu Arg Ala Leu Arg Ala 
    210                 215                 220                 


Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr Gln Lys Ala Glu Arg 
225                 230                 235                 240 


Glu Val Ser His Met Val Val Val Met Val Gly Ser Phe Cys Val Cys 
                245                 250                 255     


Tyr Val Pro Tyr Ala Ala Phe Ala Met Tyr Met Val Asn Asn Arg Asn 
            260                 265                 270         


His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro Ser Phe Phe Ser Lys 
        275                 280                 285             


Ser Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys Phe Met Asn Lys Gln 
    290                 295                 300                 


Phe Arg Ala Cys Ile Leu Glu Met Val Cys Arg Lys Pro Met Ala Asp 
305                 310                 315                 320 


Glu Ser Asp Val Ser Gly Ser Gln Lys Thr Glu Val Ser Thr Val Ser 
                325                 330                 335     


Ser Ser Lys Val Gly Pro His 
            340             


<210>  8
<211>  359
<212>  PRT
<213>  Mus Musculus

<400>  8

Met Ala Gln Arg Leu Thr Gly Glu Gln Thr Leu Asp His Tyr Glu Asp 
1               5                   10                  15      


Ser Thr His Ala Ser Ile Phe Thr Tyr Thr Asn Ser Asn Ser Thr Lys 
            20                  25                  30          


Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala Pro Arg Trp Val Tyr 
        35                  40                  45              


His Leu Thr Ser Thr Trp Met Ile Leu Val Val Val Ala Ser Val Phe 
    50                  55                  60                  


Thr Asn Gly Leu Val Leu Ala Ala Thr Met Arg Phe Lys Lys Leu Arg 
65                  70                  75                  80  


His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala Val Ala Asp Leu Ala 
                85                  90                  95      


Glu Thr Ile Ile Ala Ser Thr Ile Ser Val Val Asn Gln Ile Tyr Gly 
            100                 105                 110         


Tyr Phe Val Leu Gly His Pro Leu Cys Val Ile Glu Gly Tyr Ile Val 
        115                 120                 125             


Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu Ala Ile Ile Ser Trp 
    130                 135                 140                 


Glu Arg Trp Leu Val Val Cys Lys Pro Phe Gly Asn Val Arg Phe Asp 
145                 150                 155                 160 


Ala Lys Leu Ala Thr Val Gly Ile Val Phe Ser Trp Val Trp Ala Ala 
                165                 170                 175     


Ile Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser Arg Tyr Trp Pro Tyr 
            180                 185                 190         


Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe Ser Gly Thr Ser Tyr 
        195                 200                 205             


Pro Gly Val Gln Ser Tyr Met Met Val Leu Met Val Thr Cys Cys Ile 
    210                 215                 220                 


Phe Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu Gln Val Trp Leu Ala 
225                 230                 235                 240 


Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser Glu Ser Thr Gln Lys 
                245                 250                 255     


Ala Glu Lys Glu Val Thr Arg Met Val Val Val Met Val Phe Ala Tyr 
            260                 265                 270         


Cys Leu Cys Trp Gly Pro Tyr Thr Phe Phe Ala Cys Phe Ala Thr Ala 
        275                 280                 285             


His Pro Gly Tyr Ala Phe His Pro Leu Val Ala Ser Leu Pro Ser Tyr 
    290                 295                 300                 


Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Ile Ile Tyr Val Phe Met 
305                 310                 315                 320 


Asn Arg Gln Phe Arg Asn Cys Ile Leu His Leu Phe Gly Lys Lys Val 
                325                 330                 335     


Asp Asp Ser Ser Glu Leu Ser Ser Thr Ser Lys Thr Glu Val Ser Ser 
            340                 345                 350         


Val Ser Ser Val Ser Pro Ala 
        355                 


<210>  9
<211>  348
<212>  PRT
<213>  Mus Musculus

<400>  9

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Val 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Gln Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Phe Gly Gly Phe Thr Thr Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Val Phe Thr 
145                 150                 155                 160 


Trp Ile Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Val Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Met Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Val Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Phe Phe Leu Ile Cys Trp Leu Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Leu Pro Ala Phe Phe Ala Lys Ser Ser Ser Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Leu Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Leu Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Asp Ala Ser Ala Thr 
                325                 330                 335     


Ala Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  10
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  11
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Val Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asp Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asn Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


