                               SEQUENCE LISTING

<110> MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120> IL-33 SECRETING IMMUNORESPONSIVE CELLS AND USES THEREOF

<130> 072734.0798

<140> PCT/US2018/060992
<141> 2018-11-14

<150> 62/585,833
<151> 2017-11-14

<160> 76    

<170> PatentIn version 3.5

<210> 1
<211> 164
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210> 2
<211> 220
<212> PRT
<213> Homo sapiens

<400> 2
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210> 3
<211> 255
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210> 4
<211> 159
<212> PRT
<213> Homo sapiens

<400> 4
Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser 
1               5                   10                  15      


Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr 
            20                  25                  30          


Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val 
        35                  40                  45              


Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp 
    50                  55                  60                  


Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp 
65                  70                  75                  80  


Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys 
                85                  90                  95      


Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met 
            100                 105                 110         


His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe 
        115                 120                 125             


Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser 
    130                 135                 140                 


Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
145                 150                 155                 


<210> 5
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Glu Val Gln Leu Gln 
            20                  25                  30          


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser 
        35                  40                  45              


Cys Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val 
    50                  55                  60                  


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro 
65                  70                  75                  80  


Glu Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr 
                85                  90                  95      


Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser 
            100                 105                 110         


Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly Glu Thr 
                165                 170                 175     


Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Gly 
        195                 200                 205             


Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr Glu Asp 
225                 230                 235                 240 


Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Glu Gln Lys 
            260                 265                 270         


Leu Ile Ser Glu Glu Asp Leu Ile Glu Phe Met Tyr Pro Pro Pro Tyr 
        275                 280                 285             


Leu Asp Asn Glu Arg Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys 
    290                 295                 300                 


His Leu Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val 
305                 310                 315                 320 


Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala 
                325                 330                 335     


Leu Cys Val Ile Trp Thr Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr 
            340                 345                 350         


Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        355                 360                 365             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp 
    370                 375                 380                 


Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly 
385                 390                 395                 400 


Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     


Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             


Met Gln Thr Leu Ala Pro Arg 
    450                 455 


<210> 6
<211> 496
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Glu Val Gln Leu Gln 
            20                  25                  30          


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser 
        35                  40                  45              


Cys Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val 
    50                  55                  60                  


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro 
65                  70                  75                  80  


Glu Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr 
                85                  90                  95      


Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser 
            100                 105                 110         


Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly Glu Thr 
                165                 170                 175     


Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Gly 
        195                 200                 205             


Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr Glu Asp 
225                 230                 235                 240 


Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala Glu Gln Lys 
            260                 265                 270         


Leu Ile Ser Glu Glu Asp Leu Ile Glu Phe Met Tyr Pro Pro Pro Tyr 
        275                 280                 285             


Leu Asp Asn Glu Arg Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys 
    290                 295                 300                 


His Leu Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val 
305                 310                 315                 320 


Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala 
                325                 330                 335     


Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg 
    370                 375                 380                 


Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln 
            420                 425                 430         


Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
                485                 490                 495     


<210> 7
<211> 1491
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc tgaagtccag ctgcagcagt ctggggctga gcttgtgaga      120

cctgggacct ctgtgaagtt atcttgcaaa gtttctggcg ataccattac attttactac      180

atgcactttg tgaagcaaag gcctggacag ggtctggaat ggataggaag gattgatcct      240

gaggatgaaa gtactaaata ttctgagaag ttcaaaaaca aggcgacact cactgcagat      300

acatcttcca acacagccta cctgaagctc agcagcctga cctctgagga cactgcaacc      360

tatttttgta tctacggagg atactacttt gattactggg gccaaggggt catggtcaca      420

gtctcctcag gtggaggtgg atcaggtgga ggtggatctg gtggaggtgg atctgacatc      480

cagatgacac agtctccagc ttccctgtct acatctctgg gagaaactgt caccatccaa      540

tgtcaagcaa gtgaggacat ttacagtggt ttagcgtggt atcagcagaa gccagggaaa      600

tctcctcagc tcctgatcta tggtgcaagt gacttacaag acggcgtccc atcacgattc      660

agtggcagtg gatctggcac acagtattct ctcaagatca ccagcatgca aactgaagat      720

gaaggggttt atttctgtca acagggttta acgtatcctc ggacgttcgg tggcggcacc      780

aagctggaat tgaaacgggc ggccgcagaa cagaaactga tctctgaaga agacctgatt      840

gagttcatgt accctccgcc ttacctagac aacgagagga gcaatggaac tattattcac      900

ataaaagaga aacatctttg tcatactcag tcatctccta agctgttttg ggcactggtc      960

gtggttgctg gagtcctgtt ttgttatggc ttgctagtga cagtggctct ttgtgttatc     1020

tggacaaata gtagaaggaa cagactcctt caaagtgact acatgaacat gactccccgg     1080

aggcctgggc tcactcgaaa gccttaccag ccctacgccc ctgccagaga ctttgcagcg     1140

taccgcccca gagcaaaatt cagcaggagt gcagagactg ctgccaacct gcaggacccc     1200

aaccagctct acaatgagct caatctaggg cgaagagagg aatatgacgt cttggagaag     1260

aagcgggctc gggatccaga gatgggaggc aaacagcaga ggaggaggaa cccccaggaa     1320

ggcgtataca atgcactgca gaaagacaag atggcagaag cctacagtga gatcggcaca     1380

aaaggcgaga ggcggagagg caaggggcac gatggccttt accagggtct cagcactgcc     1440

accaaggaca cctatgatgc cctgcatatg cagaccctgg cccctcgcta a              1491


<210> 8
<211> 20
<212> PRT
<213> Homo sapiens

<400> 8
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210> 9
<211> 235
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210> 10
<211> 247
<212> PRT
<213> Mus musculus

<400> 10
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Met 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Val Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Pro 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Arg Ser Arg Lys 
    210                 215                 220                 


Arg Val Cys Lys Cys Pro Arg Pro Leu Val Arg Gln Glu Gly Lys Pro 
225                 230                 235                 240 


Arg Pro Ser Glu Lys Ile Val 
                245         


<210> 11
<211> 69
<212> PRT
<213> Mus musculus

<400> 11
Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro 
1               5                   10                  15      


Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly 
            20                  25                  30          


Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
        35                  40                  45              


Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile 
    50                  55                  60                  


Thr Leu Ile Cys Tyr 
65                  


<210> 12
<211> 207
<212> DNA
<213> Mus musculus

<400> 12
tctactacta ccaagccagt gctgcgaact ccctcacctg tgcaccctac cgggacatct       60

cagccccaga gaccagaaga ttgtcggccc cgtggctcag tgaaggggac cggattggac      120

ttcgcctgtg atatttacat ctgggcaccc ttggccggaa tctgcgtggc ccttctgctg      180

tccttgatca tcactctcat ctgctac                                          207


<210> 13
<211> 188
<212> PRT
<213> Mus musculus

<400> 13
Met Lys Trp Lys Val Ser Val Leu Ala Cys Ile Leu His Val Arg Phe 
1               5                   10                  15      


Pro Gly Ala Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Ile Thr Ala 
        35                  40                  45              


Leu Tyr Leu Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn 
    50                  55                  60                  


Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Asp Ser 
    130                 135                 140                 


His Phe Gln Ala Val Gln Phe Gly Asn Arg Arg Glu Arg Glu Gly Ser 
145                 150                 155                 160 


Glu Leu Thr Arg Thr Leu Gly Leu Arg Ala Arg Pro Lys Ala Cys Arg 
                165                 170                 175     


His Lys Lys Pro Leu Ser Leu Pro Ala Ala Val Ser 
            180                 185             


<210> 14
<211> 113
<212> PRT
<213> Mus musculus

<400> 14
Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg 
    


<210> 15
<211> 342
<212> DNA
<213> Mus musculus

<400> 15
agagcaaaat tcagcaggag tgcagagact gctgccaacc tgcaggaccc caaccagctc       60

tacaatgagc tcaatctagg gcgaagagag gaatatgacg tcttggagaa gaagcgggct      120

cgggatccag agatgggagg caaacagcag aggaggagga acccccagga aggcgtatac      180

aatgcactgc agaaagacaa gatggcagaa gcctacagtg agatcggcac aaaaggcgag      240

aggcggagag gcaaggggca cgatggcctt taccagggtc tcagcactgc caccaaggac      300

acctatgatg ccctgcatat gcagaccctg gcccctcgct aa                         342


<210> 16
<211> 218
<212> PRT
<213> Mus musculus

<400> 16
Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210> 17
<211> 123
<212> DNA
<213> Mus musculus

<400> 17
aatagtagaa ggaacagact ccttcaaagt gactacatga acatgactcc ccggaggcct       60

gggctcactc gaaagcctta ccagccctac gcccctgcca gagactttgc agcgtaccgc      120

ccc                                                                    123


<210> 18
<211> 277
<212> PRT
<213> Homo sapiens

<400> 18
Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210> 19
<211> 199
<212> PRT
<213> Homo sapiens

<400> 19
Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210> 20
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc tgaagtccag ctgcagcagt ctggggctga gcttgtgaga      120

cctgggacct ctgtgaagtt atcttgcaaa gtttctggcg ataccattac attttactac      180

atgcactttg tgaagcaaag gcctggacag ggtctggaat ggataggaag gattgatcct      240

gaggatgaaa gtactaaata ttctgagaag ttcaaaaaca aggcgacact cactgcagat      300

acatcttcca acacagccta cctgaagctc agcagcctga cctctgagga cactgcaacc      360

tatttttgta tctacggagg atactacttt gattactggg gccaaggggt catggtcaca      420

gtctcctcag gtggaggtgg atcaggtgga ggtggatctg gtggaggtgg atctgacatc      480

cagatgacac agtctccagc ttccctgtct acatctctgg gagaaactgt caccatccaa      540

tgtcaagcaa gtgaggacat ttacagtggt ttagcgtggt atcagcagaa gccagggaaa      600

tctcctcagc tcctgatcta tggtgcaagt gacttacaag acggcgtccc atcacgattc      660

agtggcagtg gatctggcac acagtattct ctcaagatca ccagcatgca aactgaagat      720

gaaggggttt atttctgtca acagggttta acgtatcctc ggacgttcgg tggcggcacc      780

aagctggaat tgaaacgggc ggccgcagaa cagaaactga tctctgaaga agacctgatt      840

gagttcatgt accctccgcc ttacctagac aacgagagga gcaatggaac tattattcac      900

ataaaagaga aacatctttg tcatactcag tcatctccta agctgttttg ggcactggtc      960

gtggttgctg gagtcctgtt ttgttatggc ttgctagtga cagtggctct ttgtgttatc     1020

tggacaagag caaaattcag caggagtgca gagactgctg ccaacctgca ggaccccaac     1080

cagctctaca atgagctcaa tctagggcga agagaggaat atgacgtctt ggagaagaag     1140

cgggctcggg atccagagat gggaggcaaa cagcagagga ggaggaaccc ccaggaaggc     1200

gtatacaatg cactgcagaa agacaagatg gcagaagcct acagtgagat cggcacaaaa     1260

ggcgagaggc ggagaggcaa ggggcacgat ggcctttacc agggtctcag cactgccacc     1320

aaggacacct atgatgccct gcatatgcag accctggccc ctcgctaa                  1368


<210> 21
<211> 158
<212> PRT
<213> Mus musculus

<400> 21
Ser Ile Gln Gly Thr Ser Leu Leu Thr Gln Ser Pro Ala Ser Leu Ser 
1               5                   10                  15      


Thr Tyr Asn Asp Gln Ser Val Ser Phe Val Leu Glu Asn Gly Cys Tyr 
            20                  25                  30          


Val Ile Asn Val Asp Asp Ser Gly Lys Asp Gln Glu Gln Asp Gln Val 
        35                  40                  45              


Leu Leu Arg Tyr Tyr Glu Ser Pro Cys Pro Ala Ser Gln Ser Gly Asp 
    50                  55                  60                  


Gly Val Asp Gly Lys Lys Leu Met Val Asn Met Ser Pro Ile Lys Asp 
65                  70                  75                  80  


Thr Asp Ile Trp Leu His Ala Asn Asp Lys Asp Tyr Ser Val Glu Leu 
                85                  90                  95      


Gln Arg Gly Asp Val Ser Pro Pro Glu Gln Ala Phe Phe Val Leu His 
            100                 105                 110         


Lys Lys Ser Ser Asp Phe Val Ser Phe Glu Cys Lys Asn Leu Pro Gly 
        115                 120                 125             


Thr Tyr Ile Gly Val Lys Asp Asn Gln Leu Ala Leu Val Glu Glu Lys 
    130                 135                 140                 


Asp Glu Ser Cys Asn Asn Ile Met Phe Lys Leu Ser Lys Ile 
145                 150                 155             


<210> 22
<211> 81
<212> DNA
<213> Homo sapiens

<400> 22
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 24
<211> 20
<212> PRT
<213> Mus musculus

<400> 24
Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser 
            20  


<210> 25
<211> 20
<212> PRT
<213> Homo sapiens

<400> 25
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210> 26
<211> 20
<212> PRT
<213> Mus musculus

<400> 26
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210> 27
<211> 21
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 28
<211> 16
<212> PRT
<213> Homo sapiens

<400> 28
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Ser Ser Ala Tyr Ser 
1               5                   10                  15      


<210> 29
<211> 30
<212> PRT
<213> Homo sapiens

<400> 29
Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Cys Gln Gly Val Val Ser 
            20                  25                  30  


<210> 30
<211> 442
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Phe Met Tyr Pro 
            260                 265                 270         


Pro Pro Tyr Leu Asp Asn Glu Arg Ser Asn Gly Thr Ile Ile His Ile 
        275                 280                 285             


Lys Glu Lys His Leu Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp 
    290                 295                 300                 


Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val 
305                 310                 315                 320 


Thr Val Ala Leu Cys Val Ile Trp Thr Arg Ala Lys Phe Ser Arg Ser 
                325                 330                 335     


Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu Tyr Asn Glu 
            340                 345                 350         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu Lys Lys Arg 
        355                 360                 365             


Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg Arg Asn Pro 
    370                 375                 380                 


Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Thr Leu Ala Pro Arg 
        435                 440         


<210> 31
<211> 1329
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgcagaggtg       60

aagctgcagc agtctggggc tgagctggtg aggcctgggt cctcagtgaa gatttcctgc      120

aaggcttctg gctatgcatt cagtagctac tggatgaact gggtgaagca gaggcctgga      180

cagggtcttg agtggattgg acagatttat cctggagatg gtgatactaa ctacaatgga      240

aagttcaagg gtcaagccac actgactgca gacaaatcct ccagcacagc ctacatgcag      300

ctcagcggcc taacatctga ggactctgcg gtctatttct gtgcaagaaa gaccattagt      360

tcggtagtag atttctactt tgactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggaggtg gatcaggtgg aggtggatct ggtggaggtg gatctgacat tgagctcacc      480

cagtctccaa aattcatgtc cacatcagta ggagacaggg tcagcgtcac ctgcaaggcc      540

agtcagaatg tgggtactaa tgtagcctgg tatcaacaga aaccaggaca atctcctaaa      600

ccactgattt actcggcaac ctaccggaac agtggagtcc ctgatcgctt cacaggcagt      660

ggatctggga cagatttcac tctcaccatc actaacgtgc agtctaaaga cttggcagac      720

tatttctgtc aacaatataa caggtatccg tacacgtccg gaggggggac caagctggag      780

atcaaacggg cggccgcaat tgagttcatg taccctccgc cttacctaga caacgagagg      840

agcaatggaa ctattattca cataaaagag aaacatcttt gtcatactca gtcatctcct      900

aagctgtttt gggcactggt cgtggttgct ggagtcctgt tttgttatgg cttgctagtg      960

acagtggctc tttgtgttat ctggacaaga gcaaaattca gcaggagtgc agagactgct     1020

gccaacctgc aggaccccaa ccagctctac aatgagctca atctagggcg aagagaggaa     1080

tatgacgtct tggagaagaa gcgggctcgg gatccagaga tgggaggcaa acagcagagg     1140

aggaggaacc cccaggaagg cgtatacaat gcactgcaga aagacaagat ggcagaagcc     1200

tacagtgaga tcggcacaaa aggcgagagg cggagaggca aggggcacga tggcctttac     1260

cagggtctca gcactgccac caaggacacc tatgatgccc tgcatatgca gaccctggcc     1320

cctcgctaa                                                             1329


<210> 32
<211> 444
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 
            260                 265                 270         


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
        275                 280                 285             


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    290                 295                 300                 


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe 
                325                 330                 335     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            340                 345                 350         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        355                 360                 365             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    370                 375                 380                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
385                 390                 395                 400 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                405                 410                 415     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            420                 425                 430         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 


<210> 33
<211> 1335
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgcagaggtg       60

aagctgcagc agtctggggc tgagctggtg aggcctgggt cctcagtgaa gatttcctgc      120

aaggcttctg gctatgcatt cagtagctac tggatgaact gggtgaagca gaggcctgga      180

cagggtcttg agtggattgg acagatttat cctggagatg gtgatactaa ctacaatgga      240

aagttcaagg gtcaagccac actgactgca gacaaatcct ccagcacagc ctacatgcag      300

ctcagcggcc taacatctga ggactctgcg gtctatttct gtgcaagaaa gaccattagt      360

tcggtagtag atttctactt tgactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggaggtg gatcaggtgg aggtggatct ggtggaggtg gatctgacat tgagctcacc      480

cagtctccaa aattcatgtc cacatcagta ggagacaggg tcagcgtcac ctgcaaggcc      540

agtcagaatg tgggtactaa tgtagcctgg tatcaacaga aaccaggaca atctcctaaa      600

ccactgattt actcggcaac ctaccggaac agtggagtcc ctgatcgctt cacaggcagt      660

ggatctggga cagatttcac tctcaccatc actaacgtgc agtctaaaga cttggcagac      720

tatttctgtc aacaatataa caggtatccg tacacgtccg gaggggggac caagctggag      780

atcaaacggg cggccgcaat tgaagttatg tatcctcctc cttacctaga caatgagaag      840

agcaatggaa ccattatcca tgtgaaaggg aaacaccttt gtccaagtcc cctatttccc      900

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      960

ttgctagtaa cagtggcctt tattattttc tgggtgagag tgaagttcag caggagcgca     1020

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1080

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1140

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1200

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1260

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1320

ctgccccctc gctag                                                      1335


<210> 34
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Phe Met Tyr Pro 
            260                 265                 270         


Pro Pro Tyr Leu Asp Asn Glu Arg Ser Asn Gly Thr Ile Ile His Ile 
        275                 280                 285             


Lys Glu Lys His Leu Cys His Thr Gln Ser Ser Pro Lys Leu Phe Trp 
    290                 295                 300                 


Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu Leu Val 
305                 310                 315                 320 


Thr Val Ala Leu Cys Val Ile Trp Thr Asn Ser Arg Arg Asn Arg Leu 
                325                 330                 335     


Leu Gln Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr 
            340                 345                 350         


Arg Lys Pro Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr 
        355                 360                 365             


Arg Pro Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu 
    370                 375                 380                 


Gln Asp Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu 
465                 470                 475                 480 


Ala Pro Arg 
            


<210> 35
<211> 1452
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgcagaggtg       60

aagctgcagc agtctggggc tgagctggtg aggcctgggt cctcagtgaa gatttcctgc      120

aaggcttctg gctatgcatt cagtagctac tggatgaact gggtgaagca gaggcctgga      180

cagggtcttg agtggattgg acagatttat cctggagatg gtgatactaa ctacaatgga      240

aagttcaagg gtcaagccac actgactgca gacaaatcct ccagcacagc ctacatgcag      300

ctcagcggcc taacatctga ggactctgcg gtctatttct gtgcaagaaa gaccattagt      360

tcggtagtag atttctactt tgactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggaggtg gatcaggtgg aggtggatct ggtggaggtg gatctgacat tgagctcacc      480

cagtctccaa aattcatgtc cacatcagta ggagacaggg tcagcgtcac ctgcaaggcc      540

agtcagaatg tgggtactaa tgtagcctgg tatcaacaga aaccaggaca atctcctaaa      600

ccactgattt actcggcaac ctaccggaac agtggagtcc ctgatcgctt cacaggcagt      660

ggatctggga cagatttcac tctcaccatc actaacgtgc agtctaaaga cttggcagac      720

tatttctgtc aacaatataa caggtatccg tacacgtccg gaggggggac caagctggag      780

atcaaacggg cggccgcaat tgagttcatg taccctccgc cttacctaga caacgagagg      840

agcaatggaa ctattattca cataaaagag aaacatcttt gtcatactca gtcatctcct      900

aagctgtttt gggcactggt cgtggttgct ggagtcctgt tttgttatgg cttgctagtg      960

acagtggctc tttgtgttat ctggacaaat agtagaagga acagactcct tcaaagtgac     1020

tacatgaaca tgactccccg gaggcctggg ctcactcgaa agccttacca gccctacgcc     1080

cctgccagag actttgcagc gtaccgcccc agagcaaaat tcagcaggag tgcagagact     1140

gctgccaacc tgcaggaccc caaccagctc tacaatgagc tcaatctagg gcgaagagag     1200

gaatatgacg tcttggagaa gaagcgggct cgggatccag agatgggagg caaacagcag     1260

aggaggagga acccccagga aggcgtatac aatgcactgc agaaagacaa gatggcagaa     1320

gcctacagtg agatcggcac aaaaggcgag aggcggagag gcaaggggca cgatggcctt     1380

taccagggtc tcagcactgc caccaaggac acctatgatg ccctgcatat gcagaccctg     1440

gcccctcgct ga                                                         1452


<210> 36
<211> 485
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 
            260                 265                 270         


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
        275                 280                 285             


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    290                 295                 300                 


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    450                 455                 460                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
465                 470                 475                 480 


Ala Leu Pro Pro Arg 
                485 


<210> 37
<211> 1458
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgcagaggtg       60

aagctgcagc agtctggggc tgagctggtg aggcctgggt cctcagtgaa gatttcctgc      120

aaggcttctg gctatgcatt cagtagctac tggatgaact gggtgaagca gaggcctgga      180

cagggtcttg agtggattgg acagatttat cctggagatg gtgatactaa ctacaatgga      240

aagttcaagg gtcaagccac actgactgca gacaaatcct ccagcacagc ctacatgcag      300

ctcagcggcc taacatctga ggactctgcg gtctatttct gtgcaagaaa gaccattagt      360

tcggtagtag atttctactt tgactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggaggtg gatcaggtgg aggtggatct ggtggaggtg gatctgacat tgagctcacc      480

cagtctccaa aattcatgtc cacatcagta ggagacaggg tcagcgtcac ctgcaaggcc      540

agtcagaatg tgggtactaa tgtagcctgg tatcaacaga aaccaggaca atctcctaaa      600

ccactgattt actcggcaac ctaccggaac agtggagtcc ctgatcgctt cacaggcagt      660

ggatctggga cagatttcac tctcaccatc actaacgtgc agtctaaaga cttggcagac      720

tatttctgtc aacaatataa caggtatccg tacacgtccg gaggggggac caagctggag      780

atcaaacggg cggccgcaat tgaagttatg tatcctcctc cttacctaga caatgagaag      840

agcaatggaa ccattatcca tgtgaaaggg aaacaccttt gtccaagtcc cctatttccc      900

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      960

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg     1020

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag     1080

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gagtgaagtt cagcaggagc     1140

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1200

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1260

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgctag                                                   1458


<210> 38
<211> 486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 
            260                 265                 270         


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
        275                 280                 285             


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    290                 295                 300                 


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210> 39
<211> 1461
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgcagaggtg       60

aagctgcagc agtctggggc tgagctggtg aggcctgggt cctcagtgaa gatttcctgc      120

aaggcttctg gctatgcatt cagtagctac tggatgaact gggtgaagca gaggcctgga      180

cagggtcttg agtggattgg acagatttat cctggagatg gtgatactaa ctacaatgga      240

aagttcaagg gtcaagccac actgactgca gacaaatcct ccagcacagc ctacatgcag      300

ctcagcggcc taacatctga ggactctgcg gtctatttct gtgcaagaaa gaccattagt      360

tcggtagtag atttctactt tgactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggaggtg gatcaggtgg aggtggatct ggtggaggtg gatctgacat tgagctcacc      480

cagtctccaa aattcatgtc cacatcagta ggagacaggg tcagcgtcac ctgcaaggcc      540

agtcagaatg tgggtactaa tgtagcctgg tatcaacaga aaccaggaca atctcctaaa      600

ccactgattt actcggcaac ctaccggaac agtggagtcc ctgatcgctt cacaggcagt      660

ggatctggga cagatttcac tctcaccatc actaacgtgc agtctaaaga cttggcagac      720

tatttctgtc aacaatataa caggtatccg tacacgtccg gaggggggac caagctggag      780

atcaaacggg cggccgcaat tgaagttatg tatcctcctc cttacctaga caatgagaag      840

agcaatggaa ccattatcca tgtgaaaggg aaacaccttt gtccaagtcc cctatttccc      900

ggaccttcta agcccttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      960

ttgctagtaa cagtggcctt tattattttc tgggtgaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta g                                               1461


<210> 40
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Phe Tyr Tyr Met His 
1               5   


<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Arg Ile Asp Pro Glu Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210> 42
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Gly Tyr Tyr Phe Asp Tyr 
1               5           


<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Gln Ala Ser Glu Asp Ile Tyr Ser Gly Leu Ala 
1               5                   10      


<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Ala Ser Asp Leu Gln Asp 
1               5           


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gln Gln Gly Leu Thr Tyr Pro Arg Thr 
1               5                   


<210> 46
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr 
            20                  25                  30          


Tyr Met His Phe Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ile Tyr Gly Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 47
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr 
65                  70                  75                  80  


Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210> 48
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gly Tyr Ala Phe Ser Ser 
1               5       


<210> 49
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Tyr Pro Gly Asp Gly Asp 
1               5       


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Lys Thr Ile Ser Ser Val Val Asp Phe 
1               5                   


<210> 51
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Asn Val Gly Thr Asn Val Ala 
1               5           


<210> 52
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Ser Ala Thr Tyr Arg Asn 
1               5       


<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Phe Cys Gln Gln Tyr Asn Arg Tyr 
1               5               


<210> 54
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 54
Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 55
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 55
Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Lys Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210> 56
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 56
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Glu Val Gln Leu Gln 
            20                  25                  30          


Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser 
        35                  40                  45              


Cys Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val 
    50                  55                  60                  


Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro 
65                  70                  75                  80  


Glu Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr 
                85                  90                  95      


Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser 
            100                 105                 110         


Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly Glu Thr 
                165                 170                 175     


Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile Tyr Gly 
        195                 200                 205             


Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr Glu Asp 
225                 230                 235                 240 


Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            260                 265     


<210> 57
<211> 798
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 57
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc tgaagtccag ctgcagcagt ctggggctga gcttgtgaga      120

cctgggacct ctgtgaagtt atcttgcaaa gtttctggcg ataccattac attttactac      180

atgcactttg tgaagcaaag gcctggacag ggtctggaat ggataggaag gattgatcct      240

gaggatgaaa gtactaaata ttctgagaag ttcaaaaaca aggcgacact cactgcagat      300

acatcttcca acacagccta cctgaagctc agcagcctga cctctgagga cactgcaacc      360

tatttttgta tctacggagg atactacttt gattactggg gccaaggggt catggtcaca      420

gtctcctcag gtggaggtgg atcaggtgga ggtggatctg gtggaggtgg atctgacatc      480

cagatgacac agtctccagc ttccctgtct acatctctgg gagaaactgt caccatccaa      540

tgtcaagcaa gtgaggacat ttacagtggt ttagcgtggt atcagcagaa gccagggaaa      600

tctcctcagc tcctgatcta tggtgcaagt gacttacaag acggcgtccc atcacgattc      660

agtggcagtg gatctggcac acagtattct ctcaagatca ccagcatgca aactgaagat      720

gaaggggttt atttctgtca acagggttta acgtatcctc ggacgttcgg tggcggcacc      780

aagctggaat tgaaacgg                                                    798


<210> 58
<211> 269
<212> PRT
<213> Mus musculus

<400> 58
Arg Pro Gln Lys Ser Leu Leu Val Glu Val Glu Glu Gly Gly Asn Val 
1               5                   10                  15      


Val Leu Pro Cys Leu Pro Asp Ser Ser Pro Val Ser Ser Glu Lys Leu 
            20                  25                  30          


Ala Trp Tyr Arg Gly Asn Gln Ser Thr Pro Phe Leu Glu Leu Ser Pro 
        35                  40                  45              


Gly Ser Pro Gly Leu Gly Leu His Val Gly Ser Leu Gly Ile Leu Leu 
    50                  55                  60                  


Val Ile Val Asn Val Ser Asp His Met Gly Gly Phe Tyr Leu Cys Gln 
65                  70                  75                  80  


Lys Arg Pro Pro Phe Lys Asp Ile Trp Gln Pro Ala Trp Thr Val Asn 
                85                  90                  95      


Val Glu Asp Ser Gly Glu Met Phe Arg Trp Asn Ala Ser Asp Val Arg 
            100                 105                 110         


Asp Leu Asp Cys Asp Leu Arg Asn Arg Ser Ser Gly Ser His Arg Ser 
        115                 120                 125             


Thr Ser Gly Ser Gln Leu Tyr Val Trp Ala Lys Asp His Pro Lys Val 
    130                 135                 140                 


Trp Gly Thr Lys Pro Val Cys Ala Pro Arg Gly Ser Ser Leu Asn Gln 
145                 150                 155                 160 


Ser Leu Ile Asn Gln Asp Leu Thr Val Ala Pro Gly Ser Thr Leu Trp 
                165                 170                 175     


Leu Ser Cys Gly Val Pro Pro Val Pro Val Ala Lys Gly Ser Ile Ser 
            180                 185                 190         


Trp Thr His Val His Pro Arg Arg Pro Asn Val Ser Leu Leu Ser Leu 
        195                 200                 205             


Ser Leu Gly Gly Glu His Pro Val Arg Glu Met Trp Val Trp Gly Ser 
    210                 215                 220                 


Leu Leu Leu Leu Pro Gln Ala Thr Ala Leu Asp Glu Gly Thr Tyr Tyr 
225                 230                 235                 240 


Cys Leu Arg Gly Asn Leu Thr Ile Glu Arg His Val Lys Val Ile Ala 
                245                 250                 255     


Arg Ser Ala Val Trp Leu Trp Leu Leu Arg Thr Gly Gly 
            260                 265                 


<210> 59
<211> 272
<212> PRT
<213> Homo sapiens

<400> 59
Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
1               5                   10                  15      


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
            20                  25                  30          


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
        35                  40                  45              


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
    50                  55                  60                  


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
                85                  90                  95      


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
            100                 105                 110         


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
        115                 120                 125             


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
    130                 135                 140                 


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
145                 150                 155                 160 


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
                165                 170                 175     


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
            180                 185                 190         


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
        195                 200                 205             


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
    210                 215                 220                 


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
225                 230                 235                 240 


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
                245                 250                 255     


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
            260                 265                 270         


<210> 60
<211> 263
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 60
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg 
            260             


<210> 61
<211> 789
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
atggctctcc cagtgactgc cctactgctt cccctagcgc ttctcctgca tgcagaggtg       60

aagctgcagc agtctggggc tgagctggtg aggcctgggt cctcagtgaa gatttcctgc      120

aaggcttctg gctatgcatt cagtagctac tggatgaact gggtgaagca gaggcctgga      180

cagggtcttg agtggattgg acagatttat cctggagatg gtgatactaa ctacaatgga      240

aagttcaagg gtcaagccac actgactgca gacaaatcct ccagcacagc ctacatgcag      300

ctcagcggcc taacatctga ggactctgcg gtctatttct gtgcaagaaa gaccattagt      360

tcggtagtag atttctactt tgactactgg ggccaaggga ccacggtcac cgtctcctca      420

ggtggaggtg gatcaggtgg aggtggatct ggtggaggtg gatctgacat tgagctcacc      480

cagtctccaa aattcatgtc cacatcagta ggagacaggg tcagcgtcac ctgcaaggcc      540

agtcagaatg tgggtactaa tgtagcctgg tatcaacaga aaccaggaca atctcctaaa      600

ccactgattt actcggcaac ctaccggaac agtggagtcc ctgatcgctt cacaggcagt      660

ggatctggga cagatttcac tctcaccatc actaacgtgc agtctaaaga cttggcagac      720

tatttctgtc aacaatataa caggtatccg tacacgtccg gaggggggac caagctggag      780

atcaaacgg                                                              789


<210> 62
<211> 18
<212> PRT
<213> Homo sapiens

<400> 62
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala 
        


<210> 63
<211> 42
<212> PRT
<213> Homo sapiens

<400> 63
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 64
<211> 126
<212> DNA
<213> Homo sapiens

<400> 64
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210> 65
<211> 41
<212> PRT
<213> Mus musculus

<400> 65
Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
        35                  40      


<210> 66
<211> 123
<212> DNA
<213> Mus musculus

<400> 66
aatagtagaa ggaacagact ccttcaaagt gactacatga acatgactcc ccggaggcct       60

gggctcactc gaaagcctta ccagccctac gcccctgcca gagactttgc agcgtaccgc      120

ccc                                                                    123


<210> 67
<211> 41
<212> PRT
<213> Homo sapiens

<400> 67
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 68
<211> 123
<212> DNA
<213> Homo sapiens

<400> 68
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210> 69
<211> 113
<212> PRT
<213> Mus musculus

<400> 69
Arg Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp 
1               5                   10                  15      


Pro Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Gln Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro 
            100                 105                 110         


Arg 
    


<210> 70
<211> 339
<212> DNA
<213> Mus musculus

<400> 70
agagcaaaat tcagcaggag tgcagagact gctgccaacc tgcaggaccc caaccagctc       60

tacaatgagc tcaatctagg gcgaagagag gaatatgacg tcttggagaa gaagcgggct      120

cgggatccag agatgggagg caaacagcag aggaggagga acccccagga aggcgtatac      180

aatgcactgc agaaagacaa gatggcagaa gcctacagtg agatcggcac aaaaggcgag      240

aggcggagag gcaaggggca cgatggcctt taccagggtc tcagcactgc caccaaggac      300

acctatgatg ccctgcatat gcagaccctg gcccctcgc                             339


<210> 71
<211> 112
<212> PRT
<213> Homo sapiens

<400> 71
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 72
<211> 336
<212> DNA
<213> Homo sapiens

<400> 72
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210> 73
<211> 27
<212> PRT
<213> Mus musculus

<400> 73
Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr 
            20                  25          


<210> 74
<211> 81
<212> DNA
<213> Mus musculus

<400> 74
ttttgggcac tggtcgtggt tgctggagtc ctgttttgtt atggcttgct agtgacagtg       60

gctctttgtg ttatctggac a                                                 81


<210> 75
<211> 27
<212> PRT
<213> Homo sapiens

<400> 75
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 76
<211> 81
<212> DNA
<213> Homo sapiens

<400> 76
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


