                         SEQUENCE LISTING

<110>  OREGON HEALTH & SCIENCE UNIVERSITY
 
<120>  NUCLEAR-TARGETED DNA REPAIR ENZYMES AND METHODS OF USE

<130>  O046-0021PCT

<150>  US 62/585,947
<151>  2017-11-14

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  DNA
<213>  HIV

<400>  1
tatggccgca aaaagcgccg tcagcgccgt cgc                                    33


<210>  2
<211>  11
<212>  PRT
<213>  HIV

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  3
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding a nuclear localization signal (NLS) 
       and TAT

<400>  3
ccaaagaaga ggaaaaggag gctatatggc cgcaaaaagc gccgtcagcg ccgtcgc          57


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for an NLS-TAT

<400>  4

Pro Lys Lys Arg Lys Arg Arg Leu Tyr Gly Arg Lys Lys Arg Arg Gln 
1               5                   10                  15      


Arg Arg Arg 
            


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding a nuclear localization signal (NLS) 
       used in the UVDE-NLS-TAT-His6 expression construct

<400>  5
ccaaagaaga ggaaaaggag g                                                 21


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of NLS used in the UVDE-NLS-TAT-His6 
       expression construct

<400>  6

Pro Lys Lys Arg Lys Arg Arg 
1               5           


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a linker

<400>  7

Leu Ala Ala Ala Leu Glu 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hexa-histidine tag

<400>  8

His His His His His His 
1               5       


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding a nuclear localization signal (NLS) 
       used in the cv-pdg-NLS-His6 expression construct

<400>  9
cccgggccaa agaaaaagag gaagaggcta                                        30


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for an NLS used in the cv-pdg-NLS-His6 
       expression construct

<400>  10

Pro Gly Pro Lys Lys Lys Arg Gly Arg Leu 
1               5                   10  


<210>  11
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding UVDE-TAT-His6

<400>  11
gatgatcatg ctccacgaga gatgtttgat tgtttggaca aacccatacc ctggcgagga       60

cgattggggt atgcttgttt gaatactatt ttaaggtcaa tgaaggagag ggttttttgt      120

tcacgcacct gccgaattac aaccattcaa cgtgatgggc tcgaaagtgt caagcagcta      180

ggtacgcaaa atgttttaga tttaatcaaa ttggttgagt ggaatcacaa ctttggcatt      240

cacttcatga gagtgagttc tgatttattt cctttcgcaa gccatgcaaa gtatggatat      300

acccttgaat ttgcacaatc tcatctcgag gaggtgggca agctggcaaa taaatataat      360

catcgattga ctatgcatcc tggtcagtac acccagatag cctctccacg agaagtcgta      420

gttgattcgg caatacgtga tttggcttat catgatgaaa ttctcagtcg tatgaagttg      480

aatgaacaat taaataaaga cgctgtttta attattcacc ttggtggtac ctttgaagga      540

aaaaaagaaa cattggatag gtttcgtaaa aattatcaac gcttgtctga ttcggttaaa      600

gctcgtttag ttttagaaaa cgatgatgtt tcttggtcag ttcaagattt attaccttta      660

tgccaagaac ttaatattcc tctagttttg gattggcatc atcacaacat agtgccagga      720

acgcttcgtg aaggaagttt agatttaatg ccattaatcc caactattcg agaaacctgg      780

acaagaaagg gaattacaca gaagcaacat tactcagaat cggctgatcc aacggcgatt      840

tctgggatga aacgacgtgc tcactctgat agggtgtttg actttccacc gtgtgatcct      900

acaatggatc taatgataga agctaaggaa aaggaacagg ctgtatttga attgtgtaga      960

cgttatgagt tacaaaatcc accatgtcct cttgaaatta tggggcctga atacgatcaa     1020

actcgagatg gatattatcc gcccggagct gaaaagcgtt taactgcaag aaaaaggcgt     1080

agtagaaaag aagaagtaga agaggatgaa aagctttatg gccgcaaaaa gcgccgtcag     1140

cgccgtcgcc accaccacca ccaccac                                         1167


<210>  12
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for a UVDE-TAT-His6 recombinant polypeptide

<400>  12

Asp Asp His Ala Pro Arg Glu Met Phe Asp Cys Leu Asp Lys Pro Ile 
1               5                   10                  15      


Pro Trp Arg Gly Arg Leu Gly Tyr Ala Cys Leu Asn Thr Ile Leu Arg 
            20                  25                  30          


Ser Met Lys Glu Arg Val Phe Cys Ser Arg Thr Cys Arg Ile Thr Thr 
        35                  40                  45              


Ile Gln Arg Asp Gly Leu Glu Ser Val Lys Gln Leu Gly Thr Gln Asn 
    50                  55                  60                  


Val Leu Asp Leu Ile Lys Leu Val Glu Trp Asn His Asn Phe Gly Ile 
65                  70                  75                  80  


His Phe Met Arg Val Ser Ser Asp Leu Phe Pro Phe Ala Ser His Ala 
                85                  90                  95      


Lys Tyr Gly Tyr Thr Leu Glu Phe Ala Gln Ser His Leu Glu Glu Val 
            100                 105                 110         


Gly Lys Leu Ala Asn Lys Tyr Asn His Arg Leu Thr Met His Pro Gly 
        115                 120                 125             


Gln Tyr Thr Gln Ile Ala Ser Pro Arg Glu Val Val Val Asp Ser Ala 
    130                 135                 140                 


Ile Arg Asp Leu Ala Tyr His Asp Glu Ile Leu Ser Arg Met Lys Leu 
145                 150                 155                 160 


Asn Glu Gln Leu Asn Lys Asp Ala Val Leu Ile Ile His Leu Gly Gly 
                165                 170                 175     


Thr Phe Glu Gly Lys Lys Glu Thr Leu Asp Arg Phe Arg Lys Asn Tyr 
            180                 185                 190         


Gln Arg Leu Ser Asp Ser Val Lys Ala Arg Leu Val Leu Glu Asn Asp 
        195                 200                 205             


Asp Val Ser Trp Ser Val Gln Asp Leu Leu Pro Leu Cys Gln Glu Leu 
    210                 215                 220                 


Asn Ile Pro Leu Val Leu Asp Trp His His His Asn Ile Val Pro Gly 
225                 230                 235                 240 


Thr Leu Arg Glu Gly Ser Leu Asp Leu Met Pro Leu Ile Pro Thr Ile 
                245                 250                 255     


Arg Glu Thr Trp Thr Arg Lys Gly Ile Thr Gln Lys Gln His Tyr Ser 
            260                 265                 270         


Glu Ser Ala Asp Pro Thr Ala Ile Ser Gly Met Lys Arg Arg Ala His 
        275                 280                 285             


Ser Asp Arg Val Phe Asp Phe Pro Pro Cys Asp Pro Thr Met Asp Leu 
    290                 295                 300                 


Met Ile Glu Ala Lys Glu Lys Glu Gln Ala Val Phe Glu Leu Cys Arg 
305                 310                 315                 320 


Arg Tyr Glu Leu Gln Asn Pro Pro Cys Pro Leu Glu Ile Met Gly Pro 
                325                 330                 335     


Glu Tyr Asp Gln Thr Arg Asp Gly Tyr Tyr Pro Pro Gly Ala Glu Lys 
            340                 345                 350         


Arg Leu Thr Ala Arg Lys Arg Arg Ser Arg Lys Glu Glu Val Glu Glu 
        355                 360                 365             


Asp Glu Lys Leu Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg His 
    370                 375                 380                 


His His His His His 
385                 


<210>  13
<211>  1191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding UVDE-NLS-TAT-His6

<400>  13
gatgatcatg ctccacgaga gatgtttgat tgtttggaca aacccatacc ctggcgagga       60

cgattggggt atgcttgttt gaatactatt ttaaggtcaa tgaaggagag ggttttttgt      120

tcacgcacct gccgaattac aaccattcaa cgtgatgggc tcgaaagtgt caagcagcta      180

ggtacgcaaa atgttttaga tttaatcaaa ttggttgagt ggaatcacaa ctttggcatt      240

cacttcatga gagtgagttc tgatttattt cctttcgcaa gccatgcaaa gtatggatat      300

acccttgaat ttgcacaatc tcatctcgag gaggtgggca agctggcaaa taaatataat      360

catcgattga ctatgcatcc tggtcagtac acccagatag cctctccacg agaagtcgta      420

gttgattcgg caatacgtga tttggcttat catgatgaaa ttctcagtcg tatgaagttg      480

aatgaacaat taaataaaga cgctgtttta attattcacc ttggtggtac ctttgaagga      540

aaaaaagaaa cattggatag gtttcgtaaa aattatcaac gcttgtctga ttcggttaaa      600

gctcgtttag ttttagaaaa cgatgatgtt tcttggtcag ttcaagattt attaccttta      660

tgccaagaac ttaatattcc tctagttttg gattggcatc atcacaacat agtgccagga      720

acgcttcgtg aaggaagttt agatttaatg ccattaatcc caactattcg agaaacctgg      780

acaagaaagg gaattacaca gaagcaacat tactcagaat cggctgatcc aacggcgatt      840

tctgggatga aacgacgtgc tcactctgat agggtgtttg actttccacc gtgtgatcct      900

acaatggatc taatgataga agctaaggaa aaggaacagg ctgtatttga attgtgtaga      960

cgttatgagt tacaaaatcc accatgtcct cttgaaatta tggggcctga atacgatcaa     1020

actcgagatg gatattatcc gcccggagct gaaaagcgtt taactgcaag aaaaaggcgt     1080

agtagaaaag aagaagtaga agaggatgaa aagcttccaa agaagaggaa aaggaggcta     1140

tatggccgca aaaagcgccg tcagcgccgt cgccaccacc accaccacca c              1191


<210>  14
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for a UVDE-NLS-TAT-His6 recombinant 
       polypeptide

<400>  14

Asp Asp His Ala Pro Arg Glu Met Phe Asp Cys Leu Asp Lys Pro Ile 
1               5                   10                  15      


Pro Trp Arg Gly Arg Leu Gly Tyr Ala Cys Leu Asn Thr Ile Leu Arg 
            20                  25                  30          


Ser Met Lys Glu Arg Val Phe Cys Ser Arg Thr Cys Arg Ile Thr Thr 
        35                  40                  45              


Ile Gln Arg Asp Gly Leu Glu Ser Val Lys Gln Leu Gly Thr Gln Asn 
    50                  55                  60                  


Val Leu Asp Leu Ile Lys Leu Val Glu Trp Asn His Asn Phe Gly Ile 
65                  70                  75                  80  


His Phe Met Arg Val Ser Ser Asp Leu Phe Pro Phe Ala Ser His Ala 
                85                  90                  95      


Lys Tyr Gly Tyr Thr Leu Glu Phe Ala Gln Ser His Leu Glu Glu Val 
            100                 105                 110         


Gly Lys Leu Ala Asn Lys Tyr Asn His Arg Leu Thr Met His Pro Gly 
        115                 120                 125             


Gln Tyr Thr Gln Ile Ala Ser Pro Arg Glu Val Val Val Asp Ser Ala 
    130                 135                 140                 


Ile Arg Asp Leu Ala Tyr His Asp Glu Ile Leu Ser Arg Met Lys Leu 
145                 150                 155                 160 


Asn Glu Gln Leu Asn Lys Asp Ala Val Leu Ile Ile His Leu Gly Gly 
                165                 170                 175     


Thr Phe Glu Gly Lys Lys Glu Thr Leu Asp Arg Phe Arg Lys Asn Tyr 
            180                 185                 190         


Gln Arg Leu Ser Asp Ser Val Lys Ala Arg Leu Val Leu Glu Asn Asp 
        195                 200                 205             


Asp Val Ser Trp Ser Val Gln Asp Leu Leu Pro Leu Cys Gln Glu Leu 
    210                 215                 220                 


Asn Ile Pro Leu Val Leu Asp Trp His His His Asn Ile Val Pro Gly 
225                 230                 235                 240 


Thr Leu Arg Glu Gly Ser Leu Asp Leu Met Pro Leu Ile Pro Thr Ile 
                245                 250                 255     


Arg Glu Thr Trp Thr Arg Lys Gly Ile Thr Gln Lys Gln His Tyr Ser 
            260                 265                 270         


Glu Ser Ala Asp Pro Thr Ala Ile Ser Gly Met Lys Arg Arg Ala His 
        275                 280                 285             


Ser Asp Arg Val Phe Asp Phe Pro Pro Cys Asp Pro Thr Met Asp Leu 
    290                 295                 300                 


Met Ile Glu Ala Lys Glu Lys Glu Gln Ala Val Phe Glu Leu Cys Arg 
305                 310                 315                 320 


Arg Tyr Glu Leu Gln Asn Pro Pro Cys Pro Leu Glu Ile Met Gly Pro 
                325                 330                 335     


Glu Tyr Asp Gln Thr Arg Asp Gly Tyr Tyr Pro Pro Gly Ala Glu Lys 
            340                 345                 350         


Arg Leu Thr Ala Arg Lys Arg Arg Ser Arg Lys Glu Glu Val Glu Glu 
        355                 360                 365             


Asp Glu Lys Leu Pro Lys Lys Arg Lys Arg Arg Leu Tyr Gly Arg Lys 
    370                 375                 380                 


Lys Arg Arg Gln Arg Arg Arg His His His His His His 
385                 390                 395         


<210>  15
<211>  1800
<212>  DNA
<213>  Schizosaccharomyces pombe

<400>  15
atgcttaggc tattgaaacg aaatattcaa atctctaaac gcattgtttt caccatatta       60

aaacaaaagg catttaaagg taatcatcct tgtgtaccgt cggtttgtac cattacttac      120

tctcgttttc attgtttacc cgataccctt aaaagtttac ttccaatgag ctcaaaaacc      180

acactctcaa tgttaccgca agttaatatc ggtgcgaatt cattctctgc cgaaacacca      240

gtcgacttaa aaaaagaaaa tgagactgag ttagctaata tcagtggacc tcacaaaaaa      300

agtacttcta cgtctacacg aaagagggca cgtagcagta aaaagaaagc gacagattct      360

gtttccgata aaattgatga gtctgttgcg tcctatgatt cttcaactca tcttaggcga      420

tcgtcgagat caaaaaaacc ggtcaactac aattcctcgt cagaatccga atcggaggag      480

caaattagta aagctactaa aaaagttaaa caaaaagagg aagaggagta tgttgaagaa      540

gtcgacgaaa agtctcttaa aaatgaaagt agctctgacg agttcgaacc ggttgtgccg      600

gaacagttgg aaactccaat ttctaaacga agacggtctc gttcttctgc aaaaaattta      660

gaaaaagaat ctacaatgaa tcttgatgat catgctccac gagagatgtt tgattgtttg      720

gacaaaccca taccctggcg aggacgattg gggtatgctt gtttgaatac tattttaagg      780

tcaatgaagg agagggtttt ttgttcacgc acctgccgaa ttacaaccat tcaacgtgat      840

gggctcgaaa gtgtcaagca gctaggtacg caaaatgttt tagatttaat caaattggtt      900

gagtggaatc acaactttgg cattcacttc atgagagtga gttctgattt atttcctttc      960

gcaagccatg caaagtatgg atataccctt gaatttgcac aatctcatct cgaggaggtg     1020

ggcaagctgg caaataaata taatcatcga ttgactatgc atcctggtca gtacacccag     1080

atagcctctc cacgagaagt cgtagttgat tcggcaatac gtgatttggc ttatcatgat     1140

gaaattctca gtcgtatgaa gttgaatgaa caattaaata aagacgctgt tttaattatt     1200

caccttggtg gtacctttga aggaaaaaaa gaaacattgg ataggtttcg taaaaattat     1260

caacgcttgt ctgattcggt taaagctcgt ttagttttag aaaacgatga tgtttcttgg     1320

tcagttcaag atttattacc tttatgccaa gaacttaata ttcctctagt tttggattgg     1380

catcatcaca acatagtgcc aggaacgctt cgtgaaggaa gtttagattt aatgccatta     1440

atcccaacta ttcgagaaac ctggacaaga aagggaatta cacagaagca acattactca     1500

gaatcggctg atccaacggc gatttctggg atgaaacgac gtgctcactc tgatagggtg     1560

tttgactttc caccgtgtga tcctacaatg gatctaatga tagaagctaa ggaaaaggaa     1620

caggctgtat ttgaattgtg tagacgttat gagttacaaa atccaccatg tcctcttgaa     1680

attatggggc ctgaatacga tcaaactcga gatggatatt atccgcccgg agctgaaaag     1740

cgtttaactg caagaaaaag gcgtagtaga aaagaagaag tagaagagga tgaaaaataa     1800


<210>  16
<211>  599
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  16

Met Leu Arg Leu Leu Lys Arg Asn Ile Gln Ile Ser Lys Arg Ile Val 
1               5                   10                  15      


Phe Thr Ile Leu Lys Gln Lys Ala Phe Lys Gly Asn His Pro Cys Val 
            20                  25                  30          


Pro Ser Val Cys Thr Ile Thr Tyr Ser Arg Phe His Cys Leu Pro Asp 
        35                  40                  45              


Thr Leu Lys Ser Leu Leu Pro Met Ser Ser Lys Thr Thr Leu Ser Met 
    50                  55                  60                  


Leu Pro Gln Val Asn Ile Gly Ala Asn Ser Phe Ser Ala Glu Thr Pro 
65                  70                  75                  80  


Val Asp Leu Lys Lys Glu Asn Glu Thr Glu Leu Ala Asn Ile Ser Gly 
                85                  90                  95      


Pro His Lys Lys Ser Thr Ser Thr Ser Thr Arg Lys Arg Ala Arg Ser 
            100                 105                 110         


Ser Lys Lys Lys Ala Thr Asp Ser Val Ser Asp Lys Ile Asp Glu Ser 
        115                 120                 125             


Val Ala Ser Tyr Asp Ser Ser Thr His Leu Arg Arg Ser Ser Arg Ser 
    130                 135                 140                 


Lys Lys Pro Val Asn Tyr Asn Ser Ser Ser Glu Ser Glu Ser Glu Glu 
145                 150                 155                 160 


Gln Ile Ser Lys Ala Thr Lys Lys Val Lys Gln Lys Glu Glu Glu Glu 
                165                 170                 175     


Tyr Val Glu Glu Val Asp Glu Lys Ser Leu Lys Asn Glu Ser Ser Ser 
            180                 185                 190         


Asp Glu Phe Glu Pro Val Val Pro Glu Gln Leu Glu Thr Pro Ile Ser 
        195                 200                 205             


Lys Arg Arg Arg Ser Arg Ser Ser Ala Lys Asn Leu Glu Lys Glu Ser 
    210                 215                 220                 


Thr Met Asn Leu Asp Asp His Ala Pro Arg Glu Met Phe Asp Cys Leu 
225                 230                 235                 240 


Asp Lys Pro Ile Pro Trp Arg Gly Arg Leu Gly Tyr Ala Cys Leu Asn 
                245                 250                 255     


Thr Ile Leu Arg Ser Met Lys Glu Arg Val Phe Cys Ser Arg Thr Cys 
            260                 265                 270         


Arg Ile Thr Thr Ile Gln Arg Asp Gly Leu Glu Ser Val Lys Gln Leu 
        275                 280                 285             


Gly Thr Gln Asn Val Leu Asp Leu Ile Lys Leu Val Glu Trp Asn His 
    290                 295                 300                 


Asn Phe Gly Ile His Phe Met Arg Val Ser Ser Asp Leu Phe Pro Phe 
305                 310                 315                 320 


Ala Ser His Ala Lys Tyr Gly Tyr Thr Leu Glu Phe Ala Gln Ser His 
                325                 330                 335     


Leu Glu Glu Val Gly Lys Leu Ala Asn Lys Tyr Asn His Arg Leu Thr 
            340                 345                 350         


Met His Pro Gly Gln Tyr Thr Gln Ile Ala Ser Pro Arg Glu Val Val 
        355                 360                 365             


Val Asp Ser Ala Ile Arg Asp Leu Ala Tyr His Asp Glu Ile Leu Ser 
    370                 375                 380                 


Arg Met Lys Leu Asn Glu Gln Leu Asn Lys Asp Ala Val Leu Ile Ile 
385                 390                 395                 400 


His Leu Gly Gly Thr Phe Glu Gly Lys Lys Glu Thr Leu Asp Arg Phe 
                405                 410                 415     


Arg Lys Asn Tyr Gln Arg Leu Ser Asp Ser Val Lys Ala Arg Leu Val 
            420                 425                 430         


Leu Glu Asn Asp Asp Val Ser Trp Ser Val Gln Asp Leu Leu Pro Leu 
        435                 440                 445             


Cys Gln Glu Leu Asn Ile Pro Leu Val Leu Asp Trp His His His Asn 
    450                 455                 460                 


Ile Val Pro Gly Thr Leu Arg Glu Gly Ser Leu Asp Leu Met Pro Leu 
465                 470                 475                 480 


Ile Pro Thr Ile Arg Glu Thr Trp Thr Arg Lys Gly Ile Thr Gln Lys 
                485                 490                 495     


Gln His Tyr Ser Glu Ser Ala Asp Pro Thr Ala Ile Ser Gly Met Lys 
            500                 505                 510         


Arg Arg Ala His Ser Asp Arg Val Phe Asp Phe Pro Pro Cys Asp Pro 
        515                 520                 525             


Thr Met Asp Leu Met Ile Glu Ala Lys Glu Lys Glu Gln Ala Val Phe 
    530                 535                 540                 


Glu Leu Cys Arg Arg Tyr Glu Leu Gln Asn Pro Pro Cys Pro Leu Glu 
545                 550                 555                 560 


Ile Met Gly Pro Glu Tyr Asp Gln Thr Arg Asp Gly Tyr Tyr Pro Pro 
                565                 570                 575     


Gly Ala Glu Lys Arg Leu Thr Ala Arg Lys Arg Arg Ser Arg Lys Glu 
            580                 585                 590         


Glu Val Glu Glu Asp Glu Lys 
        595                 


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for an SV40 large T antigen nuclear 
       localization signal (NLS)

<400>  17

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Amino acid sequence for a c-Myc nuclear localization signal (NLS)

<400>  18

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  19
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for a putative consensus sequence of the 
       bipartite nuclear localization signal (NLS)       
       (K/R)(K/R)X10-12(K/R)3/5


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Positions 3 to 12/3 to 14, any amino acid or none (such that 
       there are 10-12 amino acids)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Positions 15 to 19, any amino acid so long as 3 of the 5 are 
       either K or R

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Positions 15 to 19, any amino acid so long as 3 of the 5 are 
       either K or R

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Positions 15 to 19, any amino acid so long as 3 of the 5 are 
       either K or R

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Positions 15 to 19, any amino acid so long as 3 of the 5 are 
       either K or R

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Positions 15 to 19, any amino acid so long as 3 of the 5 are 
       either K or R

<400>  19

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  20

Pro Lys Lys Lys Arg Met Val 
1               5           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  21

Pro Lys Lys Lys Arg Lys Val Glu Asp Pro 
1               5                   10  


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  22

Pro Lys Lys Gly Ser Lys Lys Ala 
1               5               


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  23

Pro Lys Thr Lys Arg Lys Val 
1               5           


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  24

Cys Gly Gly Pro Lys Lys Lys Arg Lys Val Gly 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  25

Pro Lys Lys Lys Ile Lys Val 
1               5           


<210>  26
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  26

Cys Tyr Asp Asp Glu Ala Thr Ala Asp Ser Gln His Ser Thr Pro Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Glu Asp Pro Lys Asp Phe Glu Ser Glu Leu 
            20                  25                  30          


Leu Ser 
        


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  27

Cys Gly Tyr Gly Pro Lys Lys Lys Arg Lys Val Gly Gly 
1               5                   10              


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  28

Cys Gly Tyr Gly Val Ser Arg Lys Arg Pro Arg Pro Gly 
1               5                   10              


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  29

Ala Pro Thr Lys Arg Lys Gly Ser 
1               5               


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  30

Ala Pro Lys Arg Lys Ser Gly Val Ser Lys Cys 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  31

Pro Asn Lys Lys Lys Arg Lys 
1               5           


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  32

Glu Glu Asp Gly Pro Gln Lys Lys Lys Arg Arg Leu 
1               5                   10          


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  33

Gly Lys Lys Arg Ser Lys Ala 
1               5           


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  34

Cys Gly Gly Leu Ser Ser Lys Arg Pro Arg Pro 
1               5                   10      


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  35

Leu Lys Asp Lys Asp Ala Lys Lys Ser Lys Gln Glu 
1               5                   10          


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  36

Gly Asn Lys Ala Lys Arg Gln Arg Ser Thr 
1               5                   10  


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  37

Pro Phe Leu Asp Arg Leu Arg Arg Asp Gln Lys 
1               5                   10      


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  38

Ser Val Thr Lys Lys Arg Lys Leu Glu 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  39

Ser Ala Ser Lys Arg Arg Arg Leu Glu 
1               5                   


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  40

Pro Pro Lys Lys Arg Met Arg Arg Arg Ile Glu 
1               5                   10      


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  41

Tyr Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr 
1               5                   10                  15      


Lys Lys 
        


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  42

Lys Ile Lys Gly Ile Gln Gln Ala Thr Ala 
1               5                   10  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  43

Arg Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg 
1               5                   10                  15      


Asp 
    


<210>  44
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  44

Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
1               5                   10                  15      


Met Ile Asn Ala Cys Ile Asp Asn Leu Trp Pro Ser Pro Leu Met Ile 
            20                  25                  30          


Lys Arg Ser Lys 
        35      


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  45

Arg Lys Phe Lys Lys Phe Asn Lys 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  46

Pro Leu Leu Lys Lys Ile Lys Gln 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  47

Pro Pro Gln Lys Lys Ile Lys Ser 
1               5               


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  48

Pro Gln Pro Lys Lys Lys Pro 
1               5           


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  49

Ser Lys Arg Val Ala Lys Arg Lys Leu 
1               5                   


<210>  50
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  50

Met Thr Gly Ser Lys Thr Arg Lys His Arg Gly Ser Gly Ala 
1               5                   10                  


<210>  51
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  51

Arg His Arg Lys His Pro 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  52

Lys Arg Arg Lys His Pro 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  53

Lys Tyr Arg Lys His Pro 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  54

Lys His Arg Arg His Pro 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  55

Lys His Lys Lys His Pro 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  56

Arg His Leu Lys His Pro 
1               5       


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  57

Pro Glu Thr Thr Trp Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr 
1               5                   10                  15      


Pro 
    


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  58

Ser Pro Arg Arg Arg Arg Ser Pro Arg Arg Arg Arg Ser Gln Ser 
1               5                   10                  15  


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  59

Ala Ser Lys Ser Arg Lys Arg Lys Leu 
1               5                   


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  60

Gly Gly Leu Cys Ser Ala Arg Leu His Arg His Ala Leu Leu Ala Thr 
1               5                   10                  15      


<210>  61
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary nuclear localization signal (NLS) sequence

<400>  61

Asp Thr Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg Leu Leu Arg Leu 
1               5                   10                  15      


Asp Glu 
        


<210>  62
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding a hexahistadine tag

<400>  62
caccaccacc accaccac                                                     18


<210>  63
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding a truncated Schizosaccharomyces 
       pombe UVDE lacking amino acid residues 1 - 228

<400>  63
gatgatcatg ctccacgaga gatgtttgat tgtttggaca aacccatacc ctggcgagga       60

cgattggggt atgcttgttt gaatactatt ttaaggtcaa tgaaggagag ggttttttgt      120

tcacgcacct gccgaattac aaccattcaa cgtgatgggc tcgaaagtgt caagcagcta      180

ggtacgcaaa atgttttaga tttaatcaaa ttggttgagt ggaatcacaa ctttggcatt      240

cacttcatga gagtgagttc tgatttattt cctttcgcaa gccatgcaaa gtatggatat      300

acccttgaat ttgcacaatc tcatctcgag gaggtgggca agctggcaaa taaatataat      360

catcgattga ctatgcatcc tggtcagtac acccagatag cctctccacg agaagtcgta      420

gttgattcgg caatacgtga tttggcttat catgatgaaa ttctcagtcg tatgaagttg      480

aatgaacaat taaataaaga cgctgtttta attattcacc ttggtggtac ctttgaagga      540

aaaaaagaaa cattggatag gtttcgtaaa aattatcaac gcttgtctga ttcggttaaa      600

gctcgtttag ttttagaaaa cgatgatgtt tcttggtcag ttcaagattt attaccttta      660

tgccaagaac ttaatattcc tctagttttg gattggcatc atcacaacat agtgccagga      720

acgcttcgtg aaggaagttt agatttaatg ccattaatcc caactattcg agaaacctgg      780

acaagaaagg gaattacaca gaagcaacat tactcagaat cggctgatcc aacggcgatt      840

tctgggatga aacgacgtgc tcactctgat agggtgtttg actttccacc gtgtgatcct      900

acaatggatc taatgataga agctaaggaa aaggaacagg ctgtatttga attgtgtaga      960

cgttatgagt tacaaaatcc accatgtcct cttgaaatta tggggcctga atacgatcaa     1020

actcgagatg gatattatcc gcccggagct gaaaagcgtt taactgcaag aaaaaggcgt     1080

agtagaaaag aagaagtaga agaggatgaa aag                                  1113


<210>  64
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ?228-UVDE Amino acid sequence for a truncated Schizosaccharomyces
       pombe UVDE lacking amino acid residues 1 - 228

<400>  64

Asp Asp His Ala Pro Arg Glu Met Phe Asp Cys Leu Asp Lys Pro Ile 
1               5                   10                  15      


Pro Trp Arg Gly Arg Leu Gly Tyr Ala Cys Leu Asn Thr Ile Leu Arg 
            20                  25                  30          


Ser Met Lys Glu Arg Val Phe Cys Ser Arg Thr Cys Arg Ile Thr Thr 
        35                  40                  45              


Ile Gln Arg Asp Gly Leu Glu Ser Val Lys Gln Leu Gly Thr Gln Asn 
    50                  55                  60                  


Val Leu Asp Leu Ile Lys Leu Val Glu Trp Asn His Asn Phe Gly Ile 
65                  70                  75                  80  


His Phe Met Arg Val Ser Ser Asp Leu Phe Pro Phe Ala Ser His Ala 
                85                  90                  95      


Lys Tyr Gly Tyr Thr Leu Glu Phe Ala Gln Ser His Leu Glu Glu Val 
            100                 105                 110         


Gly Lys Leu Ala Asn Lys Tyr Asn His Arg Leu Thr Met His Pro Gly 
        115                 120                 125             


Gln Tyr Thr Gln Ile Ala Ser Pro Arg Glu Val Val Val Asp Ser Ala 
    130                 135                 140                 


Ile Arg Asp Leu Ala Tyr His Asp Glu Ile Leu Ser Arg Met Lys Leu 
145                 150                 155                 160 


Asn Glu Gln Leu Asn Lys Asp Ala Val Leu Ile Ile His Leu Gly Gly 
                165                 170                 175     


Thr Phe Glu Gly Lys Lys Glu Thr Leu Asp Arg Phe Arg Lys Asn Tyr 
            180                 185                 190         


Gln Arg Leu Ser Asp Ser Val Lys Ala Arg Leu Val Leu Glu Asn Asp 
        195                 200                 205             


Asp Val Ser Trp Ser Val Gln Asp Leu Leu Pro Leu Cys Gln Glu Leu 
    210                 215                 220                 


Asn Ile Pro Leu Val Leu Asp Trp His His His Asn Ile Val Pro Gly 
225                 230                 235                 240 


Thr Leu Arg Glu Gly Ser Leu Asp Leu Met Pro Leu Ile Pro Thr Ile 
                245                 250                 255     


Arg Glu Thr Trp Thr Arg Lys Gly Ile Thr Gln Lys Gln His Tyr Ser 
            260                 265                 270         


Glu Ser Ala Asp Pro Thr Ala Ile Ser Gly Met Lys Arg Arg Ala His 
        275                 280                 285             


Ser Asp Arg Val Phe Asp Phe Pro Pro Cys Asp Pro Thr Met Asp Leu 
    290                 295                 300                 


Met Ile Glu Ala Lys Glu Lys Glu Gln Ala Val Phe Glu Leu Cys Arg 
305                 310                 315                 320 


Arg Tyr Glu Leu Gln Asn Pro Pro Cys Pro Leu Glu Ile Met Gly Pro 
                325                 330                 335     


Glu Tyr Asp Gln Thr Arg Asp Gly Tyr Tyr Pro Pro Gly Ala Glu Lys 
            340                 345                 350         


Arg Leu Thr Ala Arg Lys Arg Arg Ser Arg Lys Glu Glu Val Glu Glu 
        355                 360                 365             


Asp Glu Lys 
    370     


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of a linker

<400>  65

Ala Ala Ala Leu Glu 
1               5   


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  66

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  67
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  67

Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  68

Tyr Ala Arg Val Arg Arg Arg Gly Pro Arg Arg 
1               5                   10      


<210>  69
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  69

Thr Lys Arg Arg Ile Thr Pro Lys Asp Val Ile Asp Val Arg Ser Thr 
1               5                   10                  15      


Val Thr Thr Glu Ile Asn Thr 
            20              


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  70

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  71
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  71

Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  72
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  72

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Pro Lys Lys Lys Arg Lys Val 
            20                  


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  73

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  74
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  74

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  75

Leu Leu Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His Ser 
1               5                   10                  15      


Lys 
    


<210>  76
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  76

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  77

Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   


<210>  78
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  78

Val Arg Leu Pro Pro Pro Val Arg Leu Pro Pro Pro Val Arg Leu Pro 
1               5                   10                  15      


Pro Pro 
        


<210>  79
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  79

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  80

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  81

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  82
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  82

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  83
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary cell-penetrating peptide

<400>  83

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210>  84
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of His6SUMO-UVDE-TAT

<400>  84

Met His His His His His His Gly Ser Leu Gln Asp Ser Glu Val Asn 
1               5                   10                  15      


Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His 
            20                  25                  30          


Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile 
        35                  40                  45              


Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg 
    50                  55                  60                  


Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp Gly Ile Glu 
65                  70                  75                  80  


Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp 
                85                  90                  95      


Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Asp Asp His Ala Pro 
            100                 105                 110         


Arg Glu Met Phe Asp Cys Leu Asp Lys Pro Ile Pro Trp Arg Gly Arg 
        115                 120                 125             


Leu Gly Tyr Ala Cys Leu Asn Thr Ile Leu Arg Ser Met Lys Glu Arg 
    130                 135                 140                 


Val Phe Cys Ser Arg Thr Cys Arg Ile Thr Thr Ile Gln Arg Asp Gly 
145                 150                 155                 160 


Leu Glu Ser Val Lys Gln Leu Gly Thr Gln Asn Val Leu Asp Leu Ile 
                165                 170                 175     


Lys Leu Val Glu Trp Asn His Asn Phe Gly Ile His Phe Met Arg Val 
            180                 185                 190         


Ser Ser Asp Leu Phe Pro Phe Ala Ser His Ala Lys Tyr Gly Tyr Thr 
        195                 200                 205             


Leu Glu Phe Ala Gln Ser His Leu Glu Glu Val Gly Lys Leu Ala Asn 
    210                 215                 220                 


Lys Tyr Asn His Arg Leu Thr Met His Pro Gly Gln Tyr Thr Gln Ile 
225                 230                 235                 240 


Ala Ser Pro Arg Glu Val Val Val Asp Ser Ala Ile Arg Asp Leu Ala 
                245                 250                 255     


Tyr His Asp Glu Ile Leu Ser Arg Met Lys Leu Asn Glu Gln Leu Asn 
            260                 265                 270         


Lys Asp Ala Val Leu Ile Ile His Leu Gly Gly Thr Phe Glu Gly Lys 
        275                 280                 285             


Lys Glu Thr Leu Asp Arg Phe Arg Lys Asn Tyr Gln Arg Leu Ser Asp 
    290                 295                 300                 


Ser Val Lys Ala Arg Leu Val Leu Glu Asn Asp Asp Val Ser Trp Ser 
305                 310                 315                 320 


Val Gln Asp Leu Leu Pro Leu Cys Gln Glu Leu Asn Ile Pro Leu Val 
                325                 330                 335     


Leu Asp Trp His His His Asn Ile Val Pro Gly Thr Leu Arg Glu Gly 
            340                 345                 350         


Ser Leu Asp Leu Met Pro Leu Ile Pro Thr Ile Arg Glu Thr Trp Thr 
        355                 360                 365             


Arg Lys Gly Ile Thr Gln Lys Gln His Tyr Ser Glu Ser Ala Asp Pro 
    370                 375                 380                 


Thr Ala Ile Ser Gly Met Lys Arg Arg Ala His Ser Asp Arg Val Phe 
385                 390                 395                 400 


Asp Phe Pro Pro Cys Asp Pro Thr Met Asp Leu Met Ile Glu Ala Lys 
                405                 410                 415     


Glu Lys Glu Gln Ala Val Phe Glu Leu Cys Arg Arg Tyr Glu Leu Gln 
            420                 425                 430         


Asn Pro Pro Cys Pro Leu Glu Ile Met Gly Pro Glu Tyr Asp Gln Thr 
        435                 440                 445             


Arg Asp Gly Tyr Tyr Pro Pro Gly Ala Glu Lys Arg Leu Thr Ala Arg 
    450                 455                 460                 


Lys Arg Arg Ser Arg Lys Glu Glu Val Glu Glu Asp Glu Lys Leu Tyr 
465                 470                 475                 480 


Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
                485                 490 


<210>  85
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence of His6SUMO-UVDE-TAT

<400>  85
atgcatcatc accaccatca cgggtccctg caggactcag aagtcaatca agaagctaag       60

ccagaggtca agccagaagt caagcctgag actcacatca atttaaaggt gtccgatgga      120

tcttcagaga tcttcttcaa gatcaaaaag accactcctt taagaaggct gatggaagcg      180

ttcgctaaaa gacagggtaa ggaaatggac tccttaacgt tcttgtacga cggtattgaa      240

attcaagctg atcagacccc tgaagatttg gacatggagg ataacgatat tattgaggct      300

caccgcgaac agattggagg tgatgatcat gctccacgag agatgtttga ttgtttggac      360

aaacccatac cctggcgagg acgattgggg tatgcttgtt tgaatactat tttaaggtca      420

atgaaggaga gggttttttg ttcacgcacc tgccgaatta caaccattca acgtgatggg      480

ctcgaaagtg tcaagcagct aggtacgcaa aatgttttag atttaatcaa attggttgag      540

tggaatcaca actttggcat tcacttcatg agagtgagtt ctgatttatt tcctttcgca      600

agccatgcaa agtatggata tacccttgaa tttgcacaat ctcatctcga ggaggtgggc      660

aagctggcaa ataaatataa tcatcgattg actatgcatc ctggtcagta cacccagata      720

gcctctccac gagaagtcgt agttgattcg gcaatacgtg atttggctta tcatgatgaa      780

attctcagtc gtatgaagtt gaatgaacaa ttaaataaag acgctgtttt aattattcac      840

cttggtggta cctttgaagg aaaaaaagaa acattggata ggtttcgtaa aaattatcaa      900

cgcttgtctg attcggttaa agctcgttta gttttagaaa acgatgatgt ttcttggtca      960

gttcaagatt tattaccttt atgccaagaa cttaatattc ctctagtttt ggattggcat     1020

catcacaaca tagtgccagg aacgcttcgt gaaggaagtt tagatttaat gccattaatc     1080

ccaactattc gagaaacctg gacaagaaag ggaattacac agaagcaaca ttactcagaa     1140

tcggctgatc caacggcgat ttctgggatg aaacgacgtg ctcactctga tagggtgttt     1200

gactttccac cgtgtgatcc tacaatggat ctaatgatag aagctaagga aaaggaacag     1260

gctgtatttg aattgtgtag acgttatgag ttacaaaatc caccatgtcc tcttgaaatt     1320

atggggcctg aatacgatca aactcgagat ggatattatc cgcccggagc tgaaaagcgt     1380

ttaactgcaa gaaaaaggcg tagtagaaaa gaagaagtag aagaggatga aaaactatat     1440

ggccgcaaaa agcgccgtca gcgccgtcgc taa                                  1473


