                         SEQUENCE LISTING

<110>  University of Georgia Research Foundation, Inc.
       YIN, HANG
       XIE, LIWEI
 
<120>  COMPOSITIONS AND METHODS FOR MODULATING HIF-2A TO IMPROVE MUSCLE 
       GENERATION AND REPAIR

<130>  UGA 2017-198

<150>  U.S.S.N. 62/588,786
<151>  2017-11-20

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  5184
<212>  DNA
<213>  Homo sapiens

<400>  1
gctttacact cgcgagcgga ccgccacacg ggtccggtgc ccgctgcgct tccgccccag       60

cgctcctgag gcggccgtac aatcctcggc agtgtcctga gactgtatgg tcagctcagc      120

ccggcctccg actccttccg actcccagca ttcgagccac tttttttttt ctttgaaaac      180

tcagaaaagt gactcctttt ccagggaaaa aggaacttgg gttcccttct ctccgtcctc      240

ttttcgggtc tgacagcctc cacccactcc ttccccggac cccgcctccg cgcgcaggtt      300

cctcccagtc acctttctcc acccccgccc ccgcacctag cccgccgcgc gccaccttcc      360

acctgactgc gcggggcgct cgggacctgc gcgcacctcg gaccttcacc acccgcccgg      420

gccgcgggga gcggacgagg gccacagccc cccacccgcc agggagccca ggtgctcggc      480

gtctgaacgt ctcaaagggc cacagcgaca atgacagctg acaaggagaa gaaaaggagt      540

agctcggaga ggaggaagga gaagtcccgg gatgctgcgc ggtgccggcg gagcaaggag      600

acggaggtgt tctatgagct ggcccatgag ctgcctctgc cccacagtgt gagctcccat      660

ctggacaagg cctccatcat gcgactggca atcagcttcc tgcgaacaca caagctcctc      720

tcctcagttt gctctgaaaa cgagtccgaa gccgaagctg accagcagat ggacaacttg      780

tacctgaaag ccttggaggg tttcattgcc gtggtgaccc aagatggcga catgatcttt      840

ctgtcagaaa acatcagcaa gttcatggga cttacacagg tggagctaac aggacatagt      900

atctttgact tcactcatcc ctgcgaccat gaggagattc gtgagaacct gagtctcaaa      960

aatggctctg gttttgggaa aaaaagcaaa gacatgtcca cagagcggga cttcttcatg     1020

aggatgaagt gcacggtcac caacagaggc cgtactgtca acctcaagtc agccacctgg     1080

aaggtcttgc actgcacggg ccaggtgaaa gtctacaaca actgccctcc tcacaatagt     1140

ctgtgtggct acaaggagcc cctgctgtcc tgcctcatca tcatgtgtga accaatccag     1200

cacccatccc acatggacat ccccctggat agcaagacct tcctgagccg ccacagcatg     1260

gacatgaagt tcacctactg tgatgacaga atcacagaac tgattggtta ccaccctgag     1320

gagctgcttg gccgctcagc ctatgaattc taccatgcgc tagactccga gaacatgacc     1380

aagagtcacc agaacttgtg caccaagggt caggtagtaa gtggccagta ccggatgctc     1440

gcaaagcatg ggggctacgt gtggctggag acccagggga cggtcatcta caaccctcgc     1500

aacctgcagc cccagtgcat catgtgtgtc aactacgtcc tgagtgagat tgagaagaat     1560

gacgtggtgt tctccatgga ccagactgaa tccctgttca agccccacct gatggccatg     1620

aacagcatct ttgatagcag tggcaagggg gctgtgtctg agaagagtaa cttcctattc     1680

accaagctaa aggaggagcc cgaggagctg gcccagctgg ctcccacccc aggagacgcc     1740

atcatctctc tggatttcgg gaatcagaac ttcgaggagt cctcagccta tggcaaggcc     1800

atcctgcccc cgagccagcc atgggccacg gagttgagga gccacagcac ccagagcgag     1860

gctgggagcc tgcctgcctt caccgtgccc caggcagctg ccccgggcag caccaccccc     1920

agtgccacca gcagcagcag cagctgctcc acgcccaata gccctgaaga ctattacaca     1980

tctttggata acgacctgaa gattgaagtg attgagaagc tcttcgccat ggacacagag     2040

gccaaggacc aatgcagtac ccagacggat ttcaatgagc tggacttgga gacactggca     2100

ccctatatcc ccatggacgg ggaagacttc cagctaagcc ccatctgccc cgaggagcgg     2160

ctcttggcgg agaacccaca gtccaccccc cagcactgct tcagtgccat gacaaacatc     2220

ttccagccac tggcccctgt agccccgcac agtcccttcc tcctggacaa gtttcagcag     2280

cagctggaga gcaagaagac agagcccgag caccggccca tgtcctccat cttctttgat     2340

gccggaagca aagcatccct gccaccgtgc tgtggccagg ccagcacccc tctctcttcc     2400

atggggggca gatccaatac ccagtggccc ccagatccac cattacattt tgggcccaca     2460

aagtgggccg tcggggatca gcgcacagag ttcttgggag cagcgccgtt ggggccccct     2520

gtctctccac cccatgtctc caccttcaag acaaggtctg caaagggttt tggggctcga     2580

ggcccagacg tgctgagtcc ggccatggta gccctctcca acaagctgaa gctgaagcga     2640

cagctggagt atgaagagca agccttccag gacctgagcg ggggggaccc acctggtggc     2700

agcacctcac atttgatgtg gaaacggatg aagaacctca ggggtgggag ctgccctttg     2760

atgccggaca agccactgag cgcaaatgta cccaatgata agttcaccca aaaccccatg     2820

aggggcctgg gccatcccct gagacatctg ccgctgccac agcctccatc tgccatcagt     2880

cccggggaga acagcaagag caggttcccc ccacagtgct acgccaccca gtaccaggac     2940

tacagcctgt cgtcagccca caaggtgtca ggcatggcaa gccggctgct cgggccctca     3000

tttgagtcct acctgctgcc cgaactgacc agatatgact gtgaggtgaa cgtgcccgtg     3060

ctgggaagct ccacgctcct gcaaggaggg gacctcctca gagccctgga ccaggccacc     3120

tgagccaggc cttctacctg ggcagcacct ctgccgacgc cgtcccacca gcttcactct     3180

ctccgtctgt ttttgcaact aggtatttct aacgccagca cactatttac aagatggact     3240

tacctggcag acttgcccag gtcaccaagc agtggccttt ttctgagatg ctcactttat     3300

tatccctatt tttaaagtac acaattgttt tacctgttct gaaatgttct taaattttgt     3360

aggatttttt tcctccccac cttcaatgac ttctaattta tattatccat aggtttctct     3420

ccctccttct ccttctcaca cacaactgtc catactaaca agtttggtgc atgtctgttc     3480

ttctgtaggg agaagcttta gcttcatttt actaaaaaga ttcctcgtta ttgttgttgc     3540

caaagagaaa caaaaatgat tttgctttcc aagcttggtt tgtggcgtct ccctcgcaga     3600

gcccttctcg tttctttttt aaactaatca ccatattgta aatttcaggg tttttttttt     3660

tttgtttaag ctgactcttt gctctaattt tggaaaaaaa gaaatgtgaa gggtcaactc     3720

caacgtatgt ggttatctgt gaaagttgca cagcgtggct tttcctaaac tggtgttttt     3780

cccccgcatt tggtggattt tttattatta ttcaaaaaca taactgagtt ttttaaaaga     3840

ggagaaaatt tatatctggg ttaagtgttt atcatatata tgggtacttt gtaatatcta     3900

aaaacttaga aacggaaatg gaatcctgct cacaaaatca ctttaagatc ttttcgaagc     3960

tgttaatttt tcttagtgtt gtggacactg cagacttgtc cagtgctccc acggcctgta     4020

cggacactgt ggaaggcctc cctctgtcgg ctttttgcca tctgtgatat gccataggtg     4080

tgacaatccg agcagtggag tcattcagcg ggagcactgc gcgctatccc ctcacattct     4140

ctatgtacta tgtatgtatg tattattatt attgctgcca agagggtctg atggcacgtt     4200

gtggggtcgg ggggtggggc ggggaagtgc tctaactttt cttaaggttt tgttgctagc     4260

ccttcaagtg cactgagcta tgtgactcgg atggtctttc acacggcaca tttggacatt     4320

tccagaacta ccatgagatg gtttagacgg gaattcatgc aaatgagggg tcaaaaatgg     4380

tatagtgacc ccgtccacgt cctccaagct cacgaccttg gagccccgtg gagctggact     4440

gaggaggagg ctgcacagcg ggagagcagc tggtccagac cagccctgca gcccccactc     4500

agccggcagc cagatggccc cgcaaggcct ccagggatgg cccctagcca caggccctgg     4560

ctgaggtctc tgggtcggtc agtgacatgt aggtaggaag cactgaaaat agtgttccca     4620

gagcactttg caactccctg ggtaagaggg acgacacctc tggtttttca ataccaatta     4680

catggaactt ttctgtaatg ggtacaatga agaagtttct aaaaacacac acaaagcaca     4740

ttgggccaac tatttagtaa gcccggatag acttattgcc aaaaacaaaa aatagctttc     4800

aaaagaaatt taagttctat gagaaattcc ttagtcatgg tgttgcgtaa atcatatttt     4860

agctgcacgg cattacccca cacagggtgg cagaacttga agggttactg acgtgtaaat     4920

gctggtattt gatttcctgt gtgtgttgcc ctggcattaa gggcatttta cccttgcagt     4980

tttactaaaa cactgaaaaa tattccaagc ttcatattaa ccctacctgt caacgtaacg     5040

atttcatgaa cgttattata ttgtcgaatt cctactgaca acattataac tgtatgggag     5100

cttaacttta taaggaaatg tattttgaca ctggtatctt attaaagtat tctgatccta     5160

ccactgaaaa aaaaaaaaaa aaaa                                            5184


<210>  2
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ala Asp Lys Glu Lys Lys Arg Ser Ser Ser Glu Arg Arg Lys 
1               5                   10                  15      


Glu Lys Ser Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys Glu Thr Glu 
            20                  25                  30          


Val Phe Tyr Glu Leu Ala His Glu Leu Pro Leu Pro His Ser Val Ser 
        35                  40                  45              


Ser His Leu Asp Lys Ala Ser Ile Met Arg Leu Ala Ile Ser Phe Leu 
    50                  55                  60                  


Arg Thr His Lys Leu Leu Ser Ser Val Cys Ser Glu Asn Glu Ser Glu 
65                  70                  75                  80  


Ala Glu Ala Asp Gln Gln Met Asp Asn Leu Tyr Leu Lys Ala Leu Glu 
                85                  90                  95      


Gly Phe Ile Ala Val Val Thr Gln Asp Gly Asp Met Ile Phe Leu Ser 
            100                 105                 110         


Glu Asn Ile Ser Lys Phe Met Gly Leu Thr Gln Val Glu Leu Thr Gly 
        115                 120                 125             


His Ser Ile Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Ile Arg 
    130                 135                 140                 


Glu Asn Leu Ser Leu Lys Asn Gly Ser Gly Phe Gly Lys Lys Ser Lys 
145                 150                 155                 160 


Asp Met Ser Thr Glu Arg Asp Phe Phe Met Arg Met Lys Cys Thr Val 
                165                 170                 175     


Thr Asn Arg Gly Arg Thr Val Asn Leu Lys Ser Ala Thr Trp Lys Val 
            180                 185                 190         


Leu His Cys Thr Gly Gln Val Lys Val Tyr Asn Asn Cys Pro Pro His 
        195                 200                 205             


Asn Ser Leu Cys Gly Tyr Lys Glu Pro Leu Leu Ser Cys Leu Ile Ile 
    210                 215                 220                 


Met Cys Glu Pro Ile Gln His Pro Ser His Met Asp Ile Pro Leu Asp 
225                 230                 235                 240 


Ser Lys Thr Phe Leu Ser Arg His Ser Met Asp Met Lys Phe Thr Tyr 
                245                 250                 255     


Cys Asp Asp Arg Ile Thr Glu Leu Ile Gly Tyr His Pro Glu Glu Leu 
            260                 265                 270         


Leu Gly Arg Ser Ala Tyr Glu Phe Tyr His Ala Leu Asp Ser Glu Asn 
        275                 280                 285             


Met Thr Lys Ser His Gln Asn Leu Cys Thr Lys Gly Gln Val Val Ser 
    290                 295                 300                 


Gly Gln Tyr Arg Met Leu Ala Lys His Gly Gly Tyr Val Trp Leu Glu 
305                 310                 315                 320 


Thr Gln Gly Thr Val Ile Tyr Asn Pro Arg Asn Leu Gln Pro Gln Cys 
                325                 330                 335     


Ile Met Cys Val Asn Tyr Val Leu Ser Glu Ile Glu Lys Asn Asp Val 
            340                 345                 350         


Val Phe Ser Met Asp Gln Thr Glu Ser Leu Phe Lys Pro His Leu Met 
        355                 360                 365             


Ala Met Asn Ser Ile Phe Asp Ser Ser Gly Lys Gly Ala Val Ser Glu 
    370                 375                 380                 


Lys Ser Asn Phe Leu Phe Thr Lys Leu Lys Glu Glu Pro Glu Glu Leu 
385                 390                 395                 400 


Ala Gln Leu Ala Pro Thr Pro Gly Asp Ala Ile Ile Ser Leu Asp Phe 
                405                 410                 415     


Gly Asn Gln Asn Phe Glu Glu Ser Ser Ala Tyr Gly Lys Ala Ile Leu 
            420                 425                 430         


Pro Pro Ser Gln Pro Trp Ala Thr Glu Leu Arg Ser His Ser Thr Gln 
        435                 440                 445             


Ser Glu Ala Gly Ser Leu Pro Ala Phe Thr Val Pro Gln Ala Ala Ala 
    450                 455                 460                 


Pro Gly Ser Thr Thr Pro Ser Ala Thr Ser Ser Ser Ser Ser Cys Ser 
465                 470                 475                 480 


Thr Pro Asn Ser Pro Glu Asp Tyr Tyr Thr Ser Leu Asp Asn Asp Leu 
                485                 490                 495     


Lys Ile Glu Val Ile Glu Lys Leu Phe Ala Met Asp Thr Glu Ala Lys 
            500                 505                 510         


Asp Gln Cys Ser Thr Gln Thr Asp Phe Asn Glu Leu Asp Leu Glu Thr 
        515                 520                 525             


Leu Ala Pro Tyr Ile Pro Met Asp Gly Glu Asp Phe Gln Leu Ser Pro 
    530                 535                 540                 


Ile Cys Pro Glu Glu Arg Leu Leu Ala Glu Asn Pro Gln Ser Thr Pro 
545                 550                 555                 560 


Gln His Cys Phe Ser Ala Met Thr Asn Ile Phe Gln Pro Leu Ala Pro 
                565                 570                 575     


Val Ala Pro His Ser Pro Phe Leu Leu Asp Lys Phe Gln Gln Gln Leu 
            580                 585                 590         


Glu Ser Lys Lys Thr Glu Pro Glu His Arg Pro Met Ser Ser Ile Phe 
        595                 600                 605             


Phe Asp Ala Gly Ser Lys Ala Ser Leu Pro Pro Cys Cys Gly Gln Ala 
    610                 615                 620                 


Ser Thr Pro Leu Ser Ser Met Gly Gly Arg Ser Asn Thr Gln Trp Pro 
625                 630                 635                 640 


Pro Asp Pro Pro Leu His Phe Gly Pro Thr Lys Trp Ala Val Gly Asp 
                645                 650                 655     


Gln Arg Thr Glu Phe Leu Gly Ala Ala Pro Leu Gly Pro Pro Val Ser 
            660                 665                 670         


Pro Pro His Val Ser Thr Phe Lys Thr Arg Ser Ala Lys Gly Phe Gly 
        675                 680                 685             


Ala Arg Gly Pro Asp Val Leu Ser Pro Ala Met Val Ala Leu Ser Asn 
    690                 695                 700                 


Lys Leu Lys Leu Lys Arg Gln Leu Glu Tyr Glu Glu Gln Ala Phe Gln 
705                 710                 715                 720 


Asp Leu Ser Gly Gly Asp Pro Pro Gly Gly Ser Thr Ser His Leu Met 
                725                 730                 735     


Trp Lys Arg Met Lys Asn Leu Arg Gly Gly Ser Cys Pro Leu Met Pro 
            740                 745                 750         


Asp Lys Pro Leu Ser Ala Asn Val Pro Asn Asp Lys Phe Thr Gln Asn 
        755                 760                 765             


Pro Met Arg Gly Leu Gly His Pro Leu Arg His Leu Pro Leu Pro Gln 
    770                 775                 780                 


Pro Pro Ser Ala Ile Ser Pro Gly Glu Asn Ser Lys Ser Arg Phe Pro 
785                 790                 795                 800 


Pro Gln Cys Tyr Ala Thr Gln Tyr Gln Asp Tyr Ser Leu Ser Ser Ala 
                805                 810                 815     


His Lys Val Ser Gly Met Ala Ser Arg Leu Leu Gly Pro Ser Phe Glu 
            820                 825                 830         


Ser Tyr Leu Leu Pro Glu Leu Thr Arg Tyr Asp Cys Glu Val Asn Val 
        835                 840                 845             


Pro Val Leu Gly Ser Ser Thr Leu Leu Gln Gly Gly Asp Leu Leu Arg 
    850                 855                 860                 


Ala Leu Asp Gln Ala Thr 
865                 870 


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  3

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  5

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  6

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  7

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  8

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu Ala 
            20                  25                  


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  9

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Gly Lys Lys Arg Ser Lys Val 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Lys Ser Arg Lys Arg Lys Leu 
1               5           


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Asp Lys 
            


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp Lys Ala 
1               5                   10                  15      


Lys Lys Ser Lys 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  15

Lys Asp Cys Val Met Asn Lys His His Arg Asn Arg Cys Gln Tyr Cys 
1               5                   10                  15      


Arg Leu Gln Arg 
            20  


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  syntehtic polypeptide

<400>  16

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  syntehtic polypeptide

<400>  17

Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210>  18
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  18
tgctgttgac agtgagcgaa cacttgatgt ggaaacgtat tagtgaagcc acagatgtaa       60

tacgtttcca catcaagtgt gtgcctactg cctcgga                                97


<210>  19
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  19
tgctgttgac agtgagcgat ccaacaagct gaagctaaag tagtgaagcc acagatgtac       60

tttagcttca gcttgttgga ctgcctactg cctcgga                                97


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  20
gagtgtcctg ggttccttgc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  21
ggcataatgc atttgcaagc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  22
cccgtcactc aaccatttca                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  23
cttatcaatg ggggctctgg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  24
agatatggct ggctttgtgc                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  25
gaactcgctc aggttctgc                                                    19


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  26
acatggcccc cgatgaat                                                     18


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  27
caggtaaggc tcgaacgatg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  28
ggatttggcc gagagttgtt                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  29
cggctaggag aaggacacta                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  30
cggcgggatc ctataagttg                                                   20


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  31
gcgtggataa tggttggca                                                    19


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  32
tcctctgaca tttgcaggtc                                                   20


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  33
aaggcattgg ctggaaga                                                     18


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  34
cgccatgtct ctagtgatcc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  35
ggtcgatgtc tgctttcctc                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  36
acttcgtgca agaaatgctg a                                                 21


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  37
tctggattgt tcttcactct tgg                                               23


<210>  38
<211>  5011
<212>  DNA
<213>  Homo sapiens

<400>  38
cttttccagg gaaaaaggaa cttgggttcc cttctctccg tcctcttttc gggtctgaca       60

gcctccaccc actccttccc cggaccccgc ctccgcgcgc aggttcctcc cagtcacctt      120

tctccacccc cgcccccgca cctagcccgc cgcgcgccac cttccacctg actgcgcggg      180

gcgctcggga cctgcgcgca cctcggacct tcaccacccg cccgggccgc ggggagcgga      240

cgagggccac agccccccac ccgccaggga gcccaggtgc tcggcgtctg aacgtctcaa      300

agggccacag cgacaatgac agctgacaag gagaagaaaa ggagtagctc ggagaggagg      360

aaggagaagt cccgggatgc tgcgcggtgc cggcggagca aggagacgga ggtgttctat      420

gagctggccc atgagctgcc tctgccccac agtgtgagct cccatctgga caaggcctcc      480

atcatgcgac tggcaatcag cttcctgcga acacacaagc tcctctcctc agtttgctct      540

gaaaacgagt ccgaagccga agctgaccag cagatggaca acttgtacct gaaagccttg      600

gagggtttca ttgccgtggt gacccaagat ggcgacatga tctttctgtc agaaaacatc      660

agcaagttca tgggacttac acaggtggag ctaacaggac atagtatctt tgacttcact      720

catccctgcg accatgagga gattcgtgag aacctgagtc tcaaaaatgg ctctggtttt      780

gggaaaaaaa gcaaagacat gtccacagag cgggacttct tcatgaggat gaagtgcacg      840

gtcaccaaca gaggccgtac tgtcaacctc aagtcagcca cctggaaggt cttgcactgc      900

acgggccagg tgaaagtcta caacaactgc cctcctcaca atagtctgtg tggctacaag      960

gagcccctgc tgtcctgcct catcatcatg tgtgaaccaa tccagcaccc atcccacatg     1020

gacatccccc tggatagcaa gaccttcctg agccgccaca gcatggacat gaagttcacc     1080

tactgtgatg acagaatcac agaactgatt ggttaccacc ctgaggagct gcttggccgc     1140

tcagcctatg aattctacca tgcgctagac tccgagaaca tgaccaagag tcaccagaac     1200

ttgtgcacca agggtcaggt agtaagtggc cagtaccgga tgctcgcaaa gcatgggggc     1260

tacgtgtggc tggagaccca ggggacggtc atctacaacc ctcgcaacct gcagccccag     1320

tgcatcatgt gtgtcaacta cgtcctgagt gagattgaga agaatgacgt ggtgttctcc     1380

atggaccaga ctgaatccct gttcaagccc cacctgatgg ccatgaacag catctttgat     1440

agcagtggca agggggctgt gtctgagaag agtaacttcc tattcaccaa gctaaaggag     1500

gagcccgagg agctggccca gctggctccc accccaggag acgccatcat ctctctggat     1560

ttcgggaatc agaacttcga ggagtcctca gcctatggca aggccatcct gcccccgagc     1620

cagccatggg ccacggagtt gaggagccac agcacccaga gcgaggctgg gagcctgcct     1680

gccttcaccg tgccccaggc agctgccccg ggcagcacca cccccagtgc caccagcagc     1740

agcagcagct gctccacgcc caatagccct gaagactatt acacatcttt ggataacgac     1800

ctgaagattg aagtgattga gaagctcttc gccatggaca cagaggccaa ggaccaatgc     1860

agtacccaga cggatttcaa tgagctggac ttggagacac tggcacccta tatccccatg     1920

gacggggaag acttccagct aagccccatc tgccccgagg agcggctctt ggcggagaac     1980

ccacagtcca ccccccagca ctgcttcagt gccatgacaa acatcttcca gccactggcc     2040

cctgtagccc cgcacagtcc cttcctcctg gacaagtttc agcagcagct ggagagcaag     2100

aagacagagc ccgagcaccg gcccatgtcc tccatcttct ttgatgccgg aagcaaagca     2160

tccctgccac cgtgctgtgg ccaggccagc acccctctct cttccatggg gggcagatcc     2220

aatacccagt ggcccccaga tccaccatta cattttgggc ccacaaagtg ggccgtcggg     2280

gatcagcgca cagagttctt gggagcagcg ccgttggggc cccctgtctc tccaccccat     2340

gtctccacct tcaagacaag gtctgcaaag ggttttgggg ctcgaggccc agacgtgctg     2400

agtccggcca tggtagccct ctccaacaag ctgaagctga agcgacagct ggagtatgaa     2460

gagcaagcct tccaggacct gagcgggggg gacccacctg gtggcagcac ctcacatttg     2520

atgtggaaac ggatgaagaa cctcaggggt gggagctgcc ctttgatgcc ggacaagcca     2580

ctgagcgcaa atgtacccaa tgataagttc acccaaaacc ccatgagggg cctgggccat     2640

cccctgagac atctgccgct gccacagcct ccatctgcca tcagtcccgg ggagaacagc     2700

aagagcaggt tccccccaca gtgctacgcc acccagtacc aggactacag cctgtcgtca     2760

gcccacaagg tgtcaggcat ggcaagccgg ctgctcgggc cctcatttga gtcctacctg     2820

ctgcccgaac tgaccagata tgactgtgag gtgaacgtgc ccgtgctggg aagctccacg     2880

ctcctgcaag gaggggacct cctcagagcc ctggaccagg ccacctgagc caggccttct     2940

acctgggcag cacctctgcc gacgccgtcc caccagcttc actctctccg tctgtttttg     3000

caactaggta tttctaacgc cagcacacta tttacaagat ggacttacct ggcagacttg     3060

cccaggtcac caagcagtgg cctttttctg agatgctcac tttattatcc ctatttttaa     3120

agtacacaat tgttttacct gttctgaaat gttcttaaat tttgtaggat ttttttcctc     3180

cccaccttca atgacttcta atttatatta tccataggtt tctctccctc cttctccttc     3240

tcacacacaa ctgtccatac taacaagttt ggtgcatgtc tgttcttctg tagggagaag     3300

ctttagcttc attttactaa aaagattcct cgttattgtt gttgccaaag agaaacaaaa     3360

atgattttgc tttccaagct tggtttgtgg cgtctccctc gcagagccct tctcgtttct     3420

tttttaaact aatcaccata ttgtaaattt cagggttttt ttttttgttt aagctgactc     3480

tttgctctaa ttttggaaaa aaagaaatgt gaagggtcaa ctccaacgta tgtggttatc     3540

tgtgaaagtt gcacagcgtg gcttttccta aactggtgtt tttcccccgc atttggtgga     3600

ttttttatta ttattcaaaa acataactga gttttttaaa agaggagaaa atttatatct     3660

gggttaagtg tttatcatat atatgggtac tttgtaatat ctaaaaactt agaaacggaa     3720

atggaatcct gctcacaaaa tcactttaag atcttttcga agctgttaat ttttcttagt     3780

gttgtggaca ctgcagactt gtccagtgct cccacggcct gtacggacac tgtggaaggc     3840

ctccctctgt cggctttttg ccatctgtga tatgccatag gtgtgacaat ccgagcagtg     3900

gagtcattca gcgggagcac tgcgcgctat cccctcacat tctctatgta ctatgtatgt     3960

atgtattatt attattgctg ccaagagggt ctgatggcac gttgtggggt cggggggtgg     4020

ggcggggaag tgctctaact tttcttaagg ttttgttgct agcccttcaa gtgcactgag     4080

ctatgtgact cggatggtct ttcacacggc acatttggac atttccagaa ctaccatgag     4140

atggtttaga cgggaattca tgcaaatgag gggtcaaaaa tggtatagtg accccgtcca     4200

cgtcctccaa gctcacgacc ttggagcccc gtggagctgg actgaggagg aggctgcaca     4260

gcgggagagc agctggtcca gaccagccct gcagccccca ctcagccggc agccagatgg     4320

ccccgcaagg cctccaggga tggcccctag ccacaggccc tggctgaggt ctctgggtcg     4380

gtcagtgaca tgtaggtagg aagcactgaa aatagtgttc ccagagcact ttgcaactcc     4440

ctgggtaaga gggacgacac ctctggtttt tcaataccaa ttacatggaa cttttctgta     4500

atgggtacaa tgaagaagtt tctaaaaaca cacacaaagc acattgggcc aactatttag     4560

taagcccgga tagacttatt gccaaaaaca aaaaatagct ttcaaaagaa atttaagttc     4620

tatgagaaat tccttagtca tggtgttgcg taaatcatat tttagctgca cggcattacc     4680

ccacacaggg tggcagaact tgaagggtta ctgacgtgta aatgctggta tttgatttcc     4740

tgtgtgtgtt gccctggcat taagggcatt ttacccttgc agttttacta aaacactgaa     4800

aaatattcca agcttcatat taaccctacc tgtcaacgta acgatttcat gaacgttatt     4860

atattgtcga attcctactg acaacattat aactgtatgg gagcttaact ttataaggaa     4920

atgtattttg acactggtat cttattaaag tattctgatc ctaaaaaaaa aaaaaaaaaa     4980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    5011


<210>  39
<211>  883
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Leu Gly Leu Phe Val Phe Lys Thr Gly Thr Gln Arg Arg Asn Arg 
1               5                   10                  15      


Arg Leu Pro Tyr Ala Arg Ser Ser Ser Glu Arg Arg Lys Glu Lys Ser 
            20                  25                  30          


Arg Asp Ala Ala Arg Cys Arg Arg Ser Lys Glu Thr Glu Val Phe Tyr 
        35                  40                  45              


Glu Leu Ala His Glu Leu Pro Leu Pro His Ser Val Ser Ser His Leu 
    50                  55                  60                  


Asp Lys Ala Ser Ile Met Arg Leu Ala Ile Ser Phe Leu Arg Thr His 
65                  70                  75                  80  


Lys Leu Leu Ser Ser Val Cys Ser Glu Asn Glu Ser Glu Ala Glu Ala 
                85                  90                  95      


Asp Gln Gln Met Asp Asn Leu Tyr Leu Lys Ala Leu Glu Gly Phe Ile 
            100                 105                 110         


Ala Val Val Thr Gln Asp Gly Asp Met Ile Phe Leu Ser Glu Asn Ile 
        115                 120                 125             


Ser Lys Phe Met Gly Leu Thr Gln Val Glu Leu Thr Gly His Ser Ile 
    130                 135                 140                 


Phe Asp Phe Thr His Pro Cys Asp His Glu Glu Ile Arg Glu Asn Leu 
145                 150                 155                 160 


Ser Leu Lys Asn Gly Ser Gly Phe Gly Lys Lys Ser Lys Asp Met Ser 
                165                 170                 175     


Thr Glu Arg Asp Phe Phe Met Arg Met Lys Cys Thr Val Thr Asn Arg 
            180                 185                 190         


Gly Arg Thr Val Asn Leu Lys Ser Ala Thr Trp Lys Val Leu His Cys 
        195                 200                 205             


Thr Gly Gln Val Lys Val Tyr Asn Asn Cys Pro Pro His Asn Ser Leu 
    210                 215                 220                 


Cys Gly Tyr Lys Glu Pro Leu Leu Ser Cys Leu Ile Ile Met Cys Glu 
225                 230                 235                 240 


Pro Ile Gln His Pro Ser His Met Asp Ile Pro Leu Asp Ser Lys Thr 
                245                 250                 255     


Phe Leu Ser Arg His Ser Met Asp Met Lys Phe Thr Tyr Cys Asp Asp 
            260                 265                 270         


Arg Ile Thr Glu Leu Ile Gly Tyr His Pro Glu Glu Leu Leu Gly Arg 
        275                 280                 285             


Ser Ala Tyr Glu Phe Tyr His Ala Leu Asp Ser Glu Asn Met Thr Lys 
    290                 295                 300                 


Ser His Gln Asn Leu Cys Thr Lys Gly Gln Val Val Ser Gly Gln Tyr 
305                 310                 315                 320 


Arg Met Leu Ala Lys His Gly Gly Tyr Val Trp Leu Glu Thr Gln Gly 
                325                 330                 335     


Thr Val Ile Tyr Asn Pro Arg Asn Leu Gln Pro Gln Cys Ile Met Cys 
            340                 345                 350         


Val Asn Tyr Val Leu Ser Glu Ile Glu Lys Asn Asp Val Val Phe Ser 
        355                 360                 365             


Met Asp Gln Thr Glu Ser Leu Phe Lys Pro His Leu Met Ala Met Asn 
    370                 375                 380                 


Ser Ile Phe Asp Ser Ser Gly Lys Gly Ala Val Ser Glu Lys Ser Asn 
385                 390                 395                 400 


Phe Leu Phe Thr Lys Leu Lys Glu Glu Pro Glu Glu Leu Ala Gln Leu 
                405                 410                 415     


Ala Pro Thr Pro Gly Asp Ala Ile Ile Ser Leu Asp Phe Gly Asn Gln 
            420                 425                 430         


Asn Phe Glu Glu Ser Ser Ala Tyr Gly Lys Ala Ile Leu Pro Pro Ser 
        435                 440                 445             


Gln Pro Trp Ala Thr Glu Leu Arg Ser His Ser Thr Gln Ser Glu Ala 
    450                 455                 460                 


Gly Ser Leu Pro Ala Phe Thr Val Pro Gln Ala Ala Ala Pro Gly Ser 
465                 470                 475                 480 


Thr Thr Pro Ser Ala Thr Ser Ser Ser Ser Ser Cys Ser Thr Pro Asn 
                485                 490                 495     


Ser Pro Glu Asp Tyr Tyr Thr Ser Leu Asp Asn Asp Leu Lys Ile Glu 
            500                 505                 510         


Val Ile Glu Lys Leu Phe Ala Met Asp Thr Glu Ala Lys Asp Gln Cys 
        515                 520                 525             


Ser Thr Gln Thr Asp Phe Asn Glu Leu Asp Leu Glu Thr Leu Ala Pro 
    530                 535                 540                 


Tyr Ile Pro Met Asp Gly Glu Asp Phe Gln Leu Ser Pro Ile Cys Pro 
545                 550                 555                 560 


Glu Glu Arg Leu Leu Ala Glu Asn Pro Gln Ser Thr Pro Gln His Cys 
                565                 570                 575     


Phe Ser Ala Met Thr Asn Ile Phe Gln Pro Leu Ala Pro Val Ala Pro 
            580                 585                 590         


His Ser Pro Phe Leu Leu Asp Lys Phe Gln Gln Gln Leu Glu Ser Lys 
        595                 600                 605             


Lys Thr Glu Pro Glu His Arg Pro Met Ser Ser Ile Phe Phe Asp Ala 
    610                 615                 620                 


Gly Ser Lys Ala Ser Leu Pro Pro Cys Cys Gly Gln Ala Ser Thr Pro 
625                 630                 635                 640 


Leu Ser Ser Met Gly Gly Arg Ser Asn Thr Gln Trp Pro Pro Asp Pro 
                645                 650                 655     


Pro Leu His Phe Gly Pro Thr Lys Trp Ala Val Gly Asp Gln Arg Thr 
            660                 665                 670         


Glu Phe Leu Gly Ala Ala Pro Leu Gly Pro Pro Val Ser Pro Pro His 
        675                 680                 685             


Val Ser Thr Phe Lys Thr Arg Ser Ala Lys Gly Phe Gly Ala Arg Gly 
    690                 695                 700                 


Pro Asp Val Leu Ser Pro Ala Met Val Ala Leu Ser Asn Lys Leu Lys 
705                 710                 715                 720 


Leu Lys Arg Gln Leu Glu Tyr Glu Glu Gln Ala Phe Gln Asp Leu Ser 
                725                 730                 735     


Gly Gly Asp Pro Pro Gly Gly Ser Thr Ser His Leu Met Trp Lys Arg 
            740                 745                 750         


Met Lys Asn Leu Arg Gly Gly Ser Cys Pro Leu Met Pro Asp Lys Pro 
        755                 760                 765             


Leu Ser Ala Asn Val Pro Asn Asp Lys Phe Thr Gln Asn Pro Met Arg 
    770                 775                 780                 


Gly Leu Gly His Pro Leu Arg His Leu Pro Leu Pro Gln Pro Pro Ser 
785                 790                 795                 800 


Ala Ile Ser Pro Gly Glu Asn Ser Lys Ser Arg Phe Pro Pro Gln Cys 
                805                 810                 815     


Tyr Ala Thr Gln Tyr Gln Asp Tyr Ser Leu Ser Ser Ala His Lys Val 
            820                 825                 830         


Ser Gly Met Ala Ser Arg Leu Leu Gly Pro Ser Phe Glu Ser Tyr Leu 
        835                 840                 845             


Leu Pro Glu Leu Thr Arg Tyr Asp Cys Glu Val Asn Val Pro Val Leu 
    850                 855                 860                 


Gly Ser Ser Thr Leu Leu Gln Gly Gly Asp Leu Leu Arg Ala Leu Asp 
865                 870                 875                 880 


Gln Ala Thr 
            


