﻿                         序列表

<110>  暨南大学

<120>  一种抑制肿瘤血管新生的peptibody多表位疫苗及其应用

<160>  6

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  345
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  peptibody多表位疫苗


<400>  1
Met Ala Ser Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr Lys Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys 
            20                  25                  30          
Ser Gly Gly Gly Gly Ser Val Ala Ser Ala Val Phe Tyr Ser Ala Leu 
        35                  40                  45              
Val Glu Gly Gly Gly Gly Ser Cys Gly Gly Gly Gly Ser Ala Met Lys 
    50                  55                  60                  
Glu Asp Gly Arg Leu Leu Ala Ser Lys Gly Gly Gly Gly Ser Ile His 
65                  70                  75                  80  
Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Gly Gly Gly Gly 
                85                  90                  95      
Ser Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr 
            100                 105                 110         
Thr Ser Gly Ser Ser Gly Val Cys Asp Lys Thr His Thr Cys Pro Pro 
        115                 120                 125             
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    130                 135                 140                 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
145                 150                 155                 160 
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                165                 170                 175     
Trp Tyr Val Asp Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            180                 185                 190         
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        195                 200                 205             
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    210                 215                 220                 
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
225                 230                 235                 240 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                245                 250                 255     
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            260                 265                 270         
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        275                 280                 285             
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    290                 295                 300                 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
305                 310                 315                 320 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                325                 330                 335     
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345 

<210>  2
<211>  1038
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  peptibody多表位疫苗的核苷酸序列


<400>  2
atggctagcc agaaacgtaa acgtaagaaa tcccgttaca aatccggtgg cggtggctcg        60
cgtccgaaga aagaccgtgc tcgtcaggaa aagaaatccg gtggcggtgg ctcggttgct       120
tccgctgttt tctactccgc tctggttgaa ggtggcggtg gctcgtgcgg cggtggtggt       180
tctgctatga aagaagacgg tcgtctgctg gcttccaaag gtggcggtgg ctcgatccac       240
ccggacggtc gtgttgacgg tgttcgtgaa aaatccggtg gcggtggctc gcgtctggaa       300
tccaacaact acaacaccta ccgttcccgt aaatacacct ccggatcctc ttgtgacaaa       360
actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc       420
ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg       480
gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg       540
gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg       600
gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag       660
gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag       720
ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag       780
gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag       840
agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc       900
tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc       960
ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc      1020
ctgtctccgg gtaaataa                                                    1038

<210>  3
<211>  33
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  上游引物F1


<400>  3
ccatgggcca gaaacgtaaa cgtaagaaat ccc                                     33

<210>  4
<211>  27
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  下游引物R1


<400>  4
ggatccggag gtgtatttac gggaacc                                            27

<210>  5
<211>  26
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  上游引物F2


<400>  5
ggatcctctt gtgacaaaac tcacac                                             26

<210>  6
<211>  26
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  下游引物R2


<400>  6
ctcgagtttt acccggagac agggag                                             26

