                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE
       THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
 
<120>  HIGHLY SPECIFIC ZIKA NEUTRALIZING HUMAN ANTIBODIES

<130>  V0139.70122WO00

<140>  Not Yet Assigned
<141>  Concurrently herewith

<150>  US 62/589,006
<151>  2017-11-21

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Thr Gly Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Phe Trp Arg Ser Gly Arg Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr His Phe Asp Ile Val Asp Tyr 
            20                  25                  30          


Asp Tyr Leu Ser Trp Tyr Gln Gln His Pro Gly Asn Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Val Ser Asn Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Ser Ile Ser 
                85                  90                  95      


Ser Thr Leu Leu Val Phe Gly Gly Gly Thr Lys Leu Ser Val 
            100                 105                 110 


<210>  3
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ala Phe Ser Asn Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Asp Asp Gly Ser Asp Gln Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Gly Gly Ser Ser Ala Tyr Asn Gly Asp Asn Gly Trp Arg Glu Ala 
            100                 105                 110         


Ala Ser Leu Asp Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  4
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Phe Cys Ser Gly Ser Ser Asn Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Asn Ser Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Arg 
                85                  90                  95      


Arg Thr Trp Val Phe Gly Gly Gly Thr Ile Val Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ala Arg Ser Asp Phe Trp Arg Ser Gly Arg Tyr Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ser Ser Tyr Ser Ile Ser Ser Thr Leu Leu Val 
1               5                   10      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Val Gly Gly Ser Ser Ala Tyr Asn Gly Asp Asn Gly Trp Arg Glu Ala 
1               5                   10                  15      


Ala Ser Leu Asp Asp 
            20      


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Ser Ser Tyr Thr Ser Arg Arg Thr Trp Val 
1               5                   10  


<210>  9
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
gaggtgcagc tgttggagtc tgggggaggc ttggttcagg cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac acctatgcca tgagttgggt ccgccagcct      120

ccagggaagg ggctggagtg ggtctccgct attagcactg gtggtggcag caaatactac      180

gcagactccg taaagggccg gctcaccatc tccagagaca attcccagaa cacgctgtat      240

ctgcagatga gcagcctgag agccgacgac acggccgtat attactgtgc gaggtccgat      300

ttttggagga gtggtcgtta ttactactac atggacgtct ggggcagagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  10
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
cagtctgccc tgactcagcc tgcctccgtg tctgcgtccc ctggacaatc gatcaccatc       60

tcctgcactg gaacccactt tgacattgtt gattatgact atctctcctg gtaccaacaa      120

cacccaggca acgcccccaa actcctgatt tatggtgtca gtaatcggcc ctcaggggtc      180

tcaagtcgct tctctggttc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgagggtga ttattattgc agctcctatt caatctccag cactctccta      300

gttttcggcg gagggacgaa gctgtccgtc                                       330


<210>  11
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc ccttagactc       60

tcctgtgtag catctggatt cgccttcagt aactatcaca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcaatt atctgggatg atggaagtga tcaatattat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacattgttt      240

ctgcaaatga acagactgag agccgaggac acggctctct attactgtgt gggaggatcc      300

tctgcctata acggtgacaa cggttggcgg gaagctgcga gcctggacga ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210>  12
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacaatc gatcaccatt       60

ttctgcagtg gaagcagcaa tgacgttgga ggttataatt atgtctcctg gtaccagcaa      120

tacccaggca aagtccccaa actcctgatt tatgatgtca atagtcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattattgc agctcatata caagtagaag aacttgggtg      300

ttcggcggag ggaccatagt gaccgtccta                                       330


<210>  13
<211>  3423
<212>  PRT
<213>  Zika virus

<400>  13

Met Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Ser Pro Phe Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Lys Lys Arg Arg Gly Ala Asp Thr Ser Val Gly Ile 
            100                 105                 110         


Val Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Val Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala 
    130                 135                 140                 


Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His 
        435                 440                 445             


Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro 
    450                 455                 460                 


Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys 
465                 470                 475                 480 


Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met 
                485                 490                 495     


Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro 
            500                 505                 510         


Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn 
        515                 520                 525             


Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr 
    530                 535                 540                 


Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala 
545                 550                 555                 560 


Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser 
                565                 570                 575     


Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly 
            580                 585                 590         


Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro 
        595                 600                 605             


Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly 
    610                 615                 620                 


Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln 
625                 630                 635                 640 


Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr 
                645                 650                 655     


Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe 
            660                 665                 670         


Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His 
        675                 680                 685             


His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr 
    690                 695                 700                 


Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp 
705                 710                 715                 720 


Phe Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His 
                725                 730                 735     


Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp 
            740                 745                 750         


Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn 
        755                 760                 765             


Thr Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val 
    770                 775                 780                 


Leu Ile Phe Leu Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val 
785                 790                 795                 800 


Asp Phe Ser Lys Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Val Tyr 
                805                 810                 815     


Asn Asp Val Glu Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser 
            820                 825                 830         


Pro Arg Arg Leu Ala Ala Ala Val Lys Gln Ala Trp Glu Asp Gly Ile 
        835                 840                 845             


Cys Gly Ile Ser Ser Val Ser Arg Met Glu Asn Ile Met Trp Arg Ser 
    850                 855                 860                 


Val Glu Gly Glu Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu 
865                 870                 875                 880 


Thr Val Val Val Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln 
                885                 890                 895     


Arg Leu Pro Val Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp 
            900                 905                 910         


Gly Lys Ser Tyr Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val 
        915                 920                 925             


Val Asp Gly Asp Thr Leu Lys Glu Cys Pro Leu Lys His Arg Ala Trp 
    930                 935                 940                 


Asn Ser Phe Leu Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser 
945                 950                 955                 960 


Val Trp Leu Lys Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala 
                965                 970                 975     


Val Ile Gly Thr Ala Val Lys Gly Lys Glu Ala Val His Ser Asp Leu 
            980                 985                 990         


Gly Tyr Trp Ile Glu Ser Glu Lys  Asn Asp Thr Trp Arg  Leu Lys Arg 
        995                 1000                 1005             


Ala His  Leu Ile Glu Met Lys  Thr Cys Glu Trp Pro  Lys Ser His 
    1010                 1015                 1020             


Thr Leu  Trp Thr Asp Gly Ile  Glu Glu Ser Asp Leu  Ile Ile Pro 
    1025                 1030                 1035             


Lys Ser  Leu Ala Gly Pro Leu  Ser His His Asn Thr  Arg Glu Gly 
    1040                 1045                 1050             


Tyr Arg  Thr Gln Met Lys Gly  Pro Trp His Ser Glu  Glu Leu Glu 
    1055                 1060                 1065             


Ile Arg  Phe Glu Glu Cys Pro  Gly Thr Lys Val His  Val Glu Glu 
    1070                 1075                 1080             


Thr Cys  Gly Thr Arg Gly Pro  Ser Leu Arg Ser Thr  Thr Ala Ser 
    1085                 1090                 1095             


Gly Arg  Val Ile Glu Glu Trp  Cys Cys Arg Glu Cys  Thr Met Pro 
    1100                 1105                 1110             


Pro Leu  Ser Phe Arg Ala Lys  Asp Gly Cys Trp Tyr  Gly Met Glu 
    1115                 1120                 1125             


Ile Arg  Pro Arg Lys Glu Pro  Glu Ser Asn Leu Val  Arg Ser Met 
    1130                 1135                 1140             


Val Thr  Ala Gly Ser Thr Asp  His Met Asp His Phe  Ser Leu Gly 
    1145                 1150                 1155             


Val Leu  Val Ile Leu Leu Met  Val Gln Glu Gly Leu  Lys Lys Arg 
    1160                 1165                 1170             


Met Thr  Thr Lys Ile Ile Ile  Ser Thr Ser Met Ala  Val Leu Val 
    1175                 1180                 1185             


Ala Met  Ile Leu Gly Gly Phe  Ser Met Ser Asp Leu  Ala Lys Leu 
    1190                 1195                 1200             


Ala Ile  Leu Met Gly Ala Thr  Phe Ala Glu Met Asn  Thr Gly Gly 
    1205                 1210                 1215             


Asp Val  Ala His Leu Ala Leu  Ile Ala Ala Phe Lys  Val Arg Pro 
    1220                 1225                 1230             


Ala Leu  Leu Val Ser Phe Ile  Phe Arg Ala Asn Trp  Thr Pro Arg 
    1235                 1240                 1245             


Glu Ser  Met Leu Leu Ala Leu  Ala Ser Cys Leu Leu  Gln Thr Ala 
    1250                 1255                 1260             


Ile Ser  Ala Leu Glu Gly Asp  Leu Met Val Leu Ile  Asn Gly Phe 
    1265                 1270                 1275             


Ala Leu  Ala Trp Leu Ala Ile  Arg Ala Met Val Val  Pro Arg Thr 
    1280                 1285                 1290             


Asp Asn  Ile Thr Leu Ala Ile  Leu Ala Ala Leu Thr  Pro Leu Ala 
    1295                 1300                 1305             


Arg Gly  Thr Leu Leu Val Ala  Trp Arg Ala Gly Leu  Ala Thr Cys 
    1310                 1315                 1320             


Gly Gly  Phe Met Leu Leu Ser  Leu Lys Gly Lys Gly  Ser Val Lys 
    1325                 1330                 1335             


Lys Asn  Leu Pro Phe Val Met  Ala Leu Gly Leu Thr  Ala Val Arg 
    1340                 1345                 1350             


Leu Val  Asp Pro Ile Asn Val  Val Gly Leu Leu Leu  Leu Thr Arg 
    1355                 1360                 1365             


Ser Gly  Lys Arg Ser Trp Pro  Pro Ser Glu Val Leu  Thr Ala Val 
    1370                 1375                 1380             


Gly Leu  Ile Cys Ala Leu Ala  Gly Gly Phe Ala Lys  Ala Asp Ile 
    1385                 1390                 1395             


Glu Met  Ala Gly Pro Met Ala  Ala Val Gly Leu Leu  Ile Val Ser 
    1400                 1405                 1410             


Tyr Val  Val Ser Gly Lys Ser  Val Asp Met Tyr Ile  Glu Arg Ala 
    1415                 1420                 1425             


Gly Asp  Ile Thr Trp Glu Lys  Asp Ala Glu Val Thr  Gly Asn Ser 
    1430                 1435                 1440             


Pro Arg  Leu Asp Val Ala Leu  Asp Glu Ser Gly Asp  Phe Ser Leu 
    1445                 1450                 1455             


Val Glu  Asp Asp Gly Pro Pro  Met Arg Glu Ile Ile  Leu Lys Val 
    1460                 1465                 1470             


Val Leu  Met Thr Ile Cys Gly  Met Asn Pro Ile Ala  Ile Pro Phe 
    1475                 1480                 1485             


Ala Ala  Gly Ala Trp Tyr Val  Tyr Val Lys Thr Gly  Lys Arg Ser 
    1490                 1495                 1500             


Gly Ala  Leu Trp Asp Val Pro  Ala Pro Lys Glu Val  Lys Lys Gly 
    1505                 1510                 1515             


Glu Thr  Thr Asp Gly Val Tyr  Arg Val Met Thr Arg  Arg Leu Leu 
    1520                 1525                 1530             


Gly Ser  Thr Gln Val Gly Val  Gly Val Met Gln Glu  Gly Val Phe 
    1535                 1540                 1545             


His Thr  Met Trp His Val Thr  Lys Gly Ser Ala Leu  Arg Ser Gly 
    1550                 1555                 1560             


Glu Gly  Arg Leu Asp Pro Tyr  Trp Gly Asp Val Lys  Gln Asp Leu 
    1565                 1570                 1575             


Val Ser  Tyr Cys Gly Pro Trp  Lys Leu Asp Ala Ala  Trp Asp Gly 
    1580                 1585                 1590             


His Ser  Glu Val Gln Leu Leu  Ala Val Pro Pro Gly  Glu Arg Ala 
    1595                 1600                 1605             


Arg Asn  Ile Gln Thr Leu Pro  Gly Ile Phe Lys Thr  Lys Asp Gly 
    1610                 1615                 1620             


Asp Ile  Gly Ala Val Ala Leu  Asp Tyr Pro Ala Gly  Thr Ser Gly 
    1625                 1630                 1635             


Ser Pro  Ile Leu Asp Lys Cys  Gly Arg Val Ile Gly  Leu Tyr Gly 
    1640                 1645                 1650             


Asn Gly  Val Val Ile Lys Asn  Gly Ser Tyr Val Ser  Ala Ile Thr 
    1655                 1660                 1665             


Gln Gly  Arg Arg Glu Glu Glu  Thr Pro Val Glu Cys  Phe Glu Pro 
    1670                 1675                 1680             


Ser Met  Leu Lys Lys Lys Gln  Leu Thr Val Leu Asp  Leu His Pro 
    1685                 1690                 1695             


Gly Ala  Gly Lys Thr Arg Arg  Val Leu Pro Glu Ile  Val Arg Glu 
    1700                 1705                 1710             


Ala Ile  Lys Thr Arg Leu Arg  Thr Val Ile Leu Ala  Pro Thr Arg 
    1715                 1720                 1725             


Val Val  Ala Ala Glu Met Glu  Glu Ala Leu Arg Gly  Leu Pro Val 
    1730                 1735                 1740             


Arg Tyr  Met Thr Thr Ala Val  Asn Val Thr His Ser  Gly Thr Glu 
    1745                 1750                 1755             


Ile Val  Asp Leu Met Cys His  Ala Thr Phe Thr Ser  Arg Leu Leu 
    1760                 1765                 1770             


Gln Pro  Ile Arg Val Pro Asn  Tyr Asn Leu Tyr Ile  Met Asp Glu 
    1775                 1780                 1785             


Ala His  Phe Thr Asp Pro Ser  Ser Ile Ala Ala Arg  Gly Tyr Ile 
    1790                 1795                 1800             


Ser Thr  Arg Val Glu Met Gly  Glu Ala Ala Ala Ile  Phe Met Thr 
    1805                 1810                 1815             


Ala Thr  Pro Pro Gly Thr Arg  Asp Ala Phe Pro Asp  Ser Asn Ser 
    1820                 1825                 1830             


Pro Ile  Met Asp Thr Glu Val  Glu Val Pro Glu Arg  Ala Trp Ser 
    1835                 1840                 1845             


Ser Gly  Phe Asp Trp Val Thr  Asp His Ser Gly Lys  Thr Val Trp 
    1850                 1855                 1860             


Phe Val  Pro Ser Val Arg Asn  Gly Asn Glu Ile Ala  Ala Cys Leu 
    1865                 1870                 1875             


Thr Lys  Ala Gly Lys Arg Val  Ile Gln Leu Ser Arg  Lys Thr Phe 
    1880                 1885                 1890             


Glu Thr  Glu Phe Gln Lys Thr  Lys His Gln Glu Trp  Asp Phe Val 
    1895                 1900                 1905             


Val Thr  Thr Asp Ile Ser Glu  Met Gly Ala Asn Phe  Lys Ala Asp 
    1910                 1915                 1920             


Arg Val  Ile Asp Ser Arg Arg  Cys Leu Lys Pro Val  Ile Leu Asp 
    1925                 1930                 1935             


Gly Glu  Arg Val Ile Leu Ala  Gly Pro Met Pro Val  Thr His Ala 
    1940                 1945                 1950             


Ser Ala  Ala Gln Arg Arg Gly  Arg Ile Gly Arg Asn  Pro Asn Lys 
    1955                 1960                 1965             


Pro Gly  Asp Glu Tyr Leu Tyr  Gly Gly Gly Cys Ala  Glu Thr Asp 
    1970                 1975                 1980             


Glu Asp  His Ala His Trp Leu  Glu Ala Arg Met Leu  Leu Asp Asn 
    1985                 1990                 1995             


Ile Tyr  Leu Gln Asp Gly Leu  Ile Ala Ser Leu Tyr  Arg Pro Glu 
    2000                 2005                 2010             


Ala Asp  Lys Val Ala Ala Ile  Glu Gly Glu Phe Lys  Leu Arg Thr 
    2015                 2020                 2025             


Glu Gln  Arg Lys Thr Phe Val  Glu Leu Met Lys Arg  Gly Asp Leu 
    2030                 2035                 2040             


Pro Val  Trp Leu Ala Tyr Gln  Val Ala Ser Ala Gly  Ile Thr Tyr 
    2045                 2050                 2055             


Thr Asp  Arg Arg Trp Cys Phe  Asp Gly Thr Thr Asn  Asn Thr Ile 
    2060                 2065                 2070             


Met Glu  Asp Ser Val Pro Ala  Glu Val Trp Thr Arg  His Gly Glu 
    2075                 2080                 2085             


Lys Arg  Val Leu Lys Pro Arg  Trp Met Asp Ala Arg  Val Cys Ser 
    2090                 2095                 2100             


Asp His  Ala Ala Leu Lys Ser  Phe Lys Glu Phe Ala  Ala Gly Lys 
    2105                 2110                 2115             


Arg Gly  Ala Ala Phe Gly Val  Met Glu Ala Leu Gly  Thr Leu Pro 
    2120                 2125                 2130             


Gly His  Met Thr Glu Arg Phe  Gln Glu Ala Ile Asp  Asn Leu Ala 
    2135                 2140                 2145             


Val Leu  Met Arg Ala Glu Thr  Gly Ser Arg Pro Tyr  Lys Ala Ala 
    2150                 2155                 2160             


Ala Ala  Gln Leu Pro Glu Thr  Leu Glu Thr Ile Met  Leu Leu Gly 
    2165                 2170                 2175             


Leu Leu  Gly Thr Val Ser Leu  Gly Ile Phe Phe Val  Leu Met Arg 
    2180                 2185                 2190             


Asn Lys  Gly Ile Gly Lys Met  Gly Phe Gly Met Val  Thr Leu Gly 
    2195                 2200                 2205             


Ala Ser  Ala Trp Leu Met Trp  Leu Ser Glu Ile Glu  Pro Ala Arg 
    2210                 2215                 2220             


Ile Ala  Cys Val Leu Ile Val  Val Phe Leu Leu Leu  Val Val Leu 
    2225                 2230                 2235             


Ile Pro  Glu Pro Glu Lys Gln  Arg Ser Pro Gln Asp  Asn Gln Met 
    2240                 2245                 2250             


Ala Ile  Ile Ile Met Val Ala  Val Gly Leu Leu Gly  Leu Ile Thr 
    2255                 2260                 2265             


Ala Asn  Glu Leu Gly Trp Leu  Glu Arg Thr Lys Ser  Asp Leu Ser 
    2270                 2275                 2280             


His Leu  Met Gly Arg Arg Glu  Glu Gly Ala Thr Ile  Gly Phe Ser 
    2285                 2290                 2295             


Met Asp  Ile Asp Leu Arg Pro  Ala Ser Ala Trp Ala  Ile Tyr Ala 
    2300                 2305                 2310             


Ala Leu  Thr Thr Phe Ile Thr  Pro Ala Val Gln His  Ala Val Thr 
    2315                 2320                 2325             


Thr Ser  Tyr Asn Asn Tyr Ser  Leu Met Ala Met Ala  Thr Gln Ala 
    2330                 2335                 2340             


Gly Val  Leu Phe Gly Met Gly  Lys Gly Met Pro Phe  Tyr Ala Trp 
    2345                 2350                 2355             


Asp Phe  Gly Val Pro Leu Leu  Met Ile Gly Cys Tyr  Ser Gln Leu 
    2360                 2365                 2370             


Thr Pro  Leu Thr Leu Ile Val  Ala Ile Ile Leu Leu  Val Ala His 
    2375                 2380                 2385             


Tyr Met  Tyr Leu Ile Pro Gly  Leu Gln Ala Ala Ala  Ala Arg Ala 
    2390                 2395                 2400             


Ala Gln  Lys Arg Thr Ala Ala  Gly Ile Met Lys Asn  Pro Val Val 
    2405                 2410                 2415             


Asp Gly  Ile Val Val Thr Asp  Ile Asp Thr Met Thr  Ile Asp Pro 
    2420                 2425                 2430             


Gln Val  Glu Lys Lys Met Gly  Gln Val Leu Leu Ile  Ala Val Ala 
    2435                 2440                 2445             


Val Ser  Ser Ala Ile Leu Ser  Arg Thr Ala Trp Gly  Trp Gly Glu 
    2450                 2455                 2460             


Ala Gly  Ala Leu Ile Thr Ala  Ala Thr Ser Thr Leu  Trp Glu Gly 
    2465                 2470                 2475             


Ser Pro  Asn Lys Tyr Trp Asn  Ser Ser Thr Ala Thr  Ser Leu Cys 
    2480                 2485                 2490             


Asn Ile  Phe Arg Gly Ser Tyr  Leu Ala Gly Ala Ser  Leu Ile Tyr 
    2495                 2500                 2505             


Thr Val  Thr Arg Asn Ala Gly  Leu Val Lys Arg Arg  Gly Gly Gly 
    2510                 2515                 2520             


Thr Gly  Glu Thr Leu Gly Glu  Lys Trp Lys Ala Arg  Leu Asn Gln 
    2525                 2530                 2535             


Met Ser  Ala Leu Glu Phe Tyr  Ser Tyr Lys Lys Ser  Gly Ile Thr 
    2540                 2545                 2550             


Glu Val  Cys Arg Glu Glu Ala  Arg Arg Ala Leu Lys  Asp Gly Val 
    2555                 2560                 2565             


Ala Thr  Gly Gly His Ala Val  Ser Arg Gly Ser Ala  Lys Leu Arg 
    2570                 2575                 2580             


Trp Leu  Val Glu Arg Gly Tyr  Leu Gln Pro Tyr Gly  Lys Val Ile 
    2585                 2590                 2595             


Asp Leu  Gly Cys Gly Arg Gly  Gly Trp Ser Tyr Tyr  Ala Ala Thr 
    2600                 2605                 2610             


Ile Arg  Lys Val Gln Glu Val  Lys Gly Tyr Thr Lys  Gly Gly Pro 
    2615                 2620                 2625             


Gly His  Glu Glu Pro Met Leu  Val Gln Ser Tyr Gly  Trp Asn Ile 
    2630                 2635                 2640             


Val Arg  Leu Lys Ser Gly Val  Asp Val Phe His Met  Ala Ala Glu 
    2645                 2650                 2655             


Pro Cys  Asp Thr Leu Leu Cys  Asp Ile Gly Glu Ser  Ser Ser Ser 
    2660                 2665                 2670             


Pro Glu  Val Glu Glu Ala Arg  Thr Leu Arg Val Leu  Ser Met Val 
    2675                 2680                 2685             


Gly Asp  Trp Leu Glu Lys Arg  Pro Gly Ala Phe Cys  Ile Lys Val 
    2690                 2695                 2700             


Leu Cys  Pro Tyr Thr Ser Thr  Met Met Glu Thr Leu  Glu Arg Leu 
    2705                 2710                 2715             


Gln Arg  Arg Tyr Gly Gly Gly  Leu Val Arg Val Pro  Leu Ser Arg 
    2720                 2725                 2730             


Asn Ser  Thr His Glu Met Tyr  Trp Val Ser Gly Ala  Lys Ser Asn 
    2735                 2740                 2745             


Thr Ile  Lys Ser Val Ser Thr  Thr Ser Gln Leu Leu  Leu Gly Arg 
    2750                 2755                 2760             


Met Asp  Gly Pro Arg Arg Pro  Val Lys Tyr Glu Glu  Asp Val Asn 
    2765                 2770                 2775             


Leu Gly  Ser Gly Thr Arg Ala  Val Val Ser Cys Ala  Glu Ala Pro 
    2780                 2785                 2790             


Asn Met  Lys Ile Ile Gly Asn  Arg Ile Glu Arg Ile  Arg Ser Glu 
    2795                 2800                 2805             


His Ala  Glu Thr Trp Phe Phe  Asp Glu Asn His Pro  Tyr Arg Thr 
    2810                 2815                 2820             


Trp Ala  Tyr His Gly Ser Tyr  Glu Ala Pro Thr Gln  Gly Ser Ala 
    2825                 2830                 2835             


Ser Ser  Leu Ile Asn Gly Val  Val Arg Leu Leu Ser  Lys Pro Trp 
    2840                 2845                 2850             


Asp Val  Val Thr Gly Val Thr  Gly Ile Ala Met Thr  Asp Thr Thr 
    2855                 2860                 2865             


Pro Tyr  Gly Gln Gln Arg Val  Phe Lys Glu Lys Val  Asp Thr Arg 
    2870                 2875                 2880             


Val Pro  Asp Pro Gln Glu Gly  Thr Arg Gln Val Met  Ser Met Val 
    2885                 2890                 2895             


Ser Ser  Trp Leu Trp Lys Glu  Leu Gly Lys His Lys  Arg Pro Arg 
    2900                 2905                 2910             


Val Cys  Thr Lys Glu Glu Phe  Ile Asn Lys Val Arg  Ser Asn Ala 
    2915                 2920                 2925             


Ala Leu  Gly Ala Ile Phe Glu  Glu Glu Lys Glu Trp  Lys Thr Ala 
    2930                 2935                 2940             


Val Glu  Ala Val Asn Asp Pro  Arg Phe Trp Ala Leu  Val Asp Lys 
    2945                 2950                 2955             


Glu Arg  Glu His His Leu Arg  Gly Glu Cys Gln Ser  Cys Val Tyr 
    2960                 2965                 2970             


Asn Met  Met Gly Lys Arg Glu  Lys Lys Gln Gly Glu  Phe Gly Lys 
    2975                 2980                 2985             


Ala Lys  Gly Ser Arg Ala Ile  Trp Tyr Met Trp Leu  Gly Ala Arg 
    2990                 2995                 3000             


Phe Leu  Glu Phe Glu Ala Leu  Gly Phe Leu Asn Glu  Asp His Trp 
    3005                 3010                 3015             


Met Gly  Arg Glu Asn Ser Gly  Gly Gly Val Glu Gly  Leu Gly Leu 
    3020                 3025                 3030             


Gln Arg  Leu Gly Tyr Val Leu  Glu Glu Met Ser Arg  Ile Pro Gly 
    3035                 3040                 3045             


Gly Arg  Met Tyr Ala Asp Asp  Thr Ala Gly Trp Asp  Thr Arg Ile 
    3050                 3055                 3060             


Ser Arg  Phe Asp Leu Glu Asn  Glu Ala Leu Ile Thr  Asn Gln Met 
    3065                 3070                 3075             


Glu Lys  Gly His Arg Ala Leu  Ala Leu Ala Ile Ile  Lys Tyr Thr 
    3080                 3085                 3090             


Tyr Gln  Asn Lys Val Val Lys  Val Leu Arg Pro Ala  Glu Lys Gly 
    3095                 3100                 3105             


Lys Thr  Val Met Asp Ile Ile  Ser Arg Gln Asp Gln  Arg Gly Ser 
    3110                 3115                 3120             


Gly Gln  Val Val Thr Tyr Ala  Leu Asn Thr Phe Thr  Asn Leu Val 
    3125                 3130                 3135             


Val Gln  Leu Ile Arg Asn Met  Glu Ala Glu Glu Val  Leu Glu Met 
    3140                 3145                 3150             


Gln Asp  Leu Trp Leu Leu Arg  Arg Ser Glu Lys Val  Thr Asn Trp 
    3155                 3160                 3165             


Leu Gln  Ser Asn Gly Trp Asp  Arg Leu Lys Arg Met  Ala Val Ser 
    3170                 3175                 3180             


Gly Asp  Asp Cys Val Val Lys  Pro Ile Asp Asp Arg  Phe Ala His 
    3185                 3190                 3195             


Ala Leu  Arg Phe Leu Asn Asp  Met Gly Lys Val Arg  Lys Asp Thr 
    3200                 3205                 3210             


Gln Glu  Trp Lys Pro Ser Thr  Gly Trp Asp Asn Trp  Glu Glu Val 
    3215                 3220                 3225             


Pro Phe  Cys Ser His His Phe  Asn Lys Leu His Leu  Lys Asp Gly 
    3230                 3235                 3240             


Arg Ser  Ile Val Val Pro Cys  Arg His Gln Asp Glu  Leu Ile Gly 
    3245                 3250                 3255             


Arg Ala  Arg Val Ser Pro Gly  Ala Gly Trp Ser Ile  Arg Glu Thr 
    3260                 3265                 3270             


Ala Cys  Leu Ala Lys Ser Tyr  Ala Gln Met Trp Gln  Leu Leu Tyr 
    3275                 3280                 3285             


Phe His  Arg Arg Asp Leu Arg  Leu Met Ala Asn Ala  Ile Cys Ser 
    3290                 3295                 3300             


Ser Val  Pro Val Asp Trp Val  Pro Thr Gly Arg Thr  Thr Trp Ser 
    3305                 3310                 3315             


Ile His  Gly Lys Gly Glu Trp  Met Thr Thr Glu Asp  Met Leu Val 
    3320                 3325                 3330             


Val Trp  Asn Arg Val Trp Ile  Glu Glu Asn Asp His  Met Glu Asp 
    3335                 3340                 3345             


Lys Thr  Pro Val Thr Lys Trp  Thr Asp Ile Pro Tyr  Leu Gly Lys 
    3350                 3355                 3360             


Arg Glu  Asp Leu Trp Cys Gly  Ser Leu Ile Gly His  Arg Pro Arg 
    3365                 3370                 3375             


Thr Thr  Trp Ala Glu Asn Ile  Lys Asn Thr Val Asn  Met Val Arg 
    3380                 3385                 3390             


Arg Ile  Ile Gly Asp Glu Glu  Lys Tyr Met Asp Tyr  Leu Ser Thr 
    3395                 3400                 3405             


Gln Val  Arg Tyr Leu Gly Glu  Glu Gly Ser Thr Pro  Gly Val Leu 
    3410                 3415                 3420             


<210>  14
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  15
<211>  3419
<212>  PRT
<213>  Zika virus

<400>  15

Met Lys Asn Pro Lys Glu Glu Ile Arg Arg Ile Arg Ile Val Asn Met 
1               5                   10                  15      


Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Leu Lys Arg 
            20                  25                  30          


Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met Val Leu 
        35                  40                  45              


Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser Leu Gly 
    50                  55                  60                  


Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met Glu Ile 
65                  70                  75                  80  


Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile Ile Asn 
                85                  90                  95      


Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile Gly Ile 
            100                 105                 110         


Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile Thr Arg Arg 
        115                 120                 125             


Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala 
    130                 135                 140                 


Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys His Val Gln Ile 
145                 150                 155                 160 


Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro 
                165                 170                 175     


Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn 
            180                 185                 190         


Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly 
        195                 200                 205             


Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr 
    210                 215                 220                 


Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr 
225                 230                 235                 240 


Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe Arg Asn Pro Gly 
                245                 250                 255     


Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr 
            260                 265                 270         


Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala 
        275                 280                 285             


Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly 
    290                 295                 300                 


Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys 
305                 310                 315                 320 


Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val 
                325                 330                 335     


Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu 
            340                 345                 350         


Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly 
        355                 360                 365             


Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg 
    370                 375                 380                 


Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys 
385                 390                 395                 400 


Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser Lys Lys Met Thr 
                405                 410                 415     


Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser 
            420                 425                 430         


Val His Gly Ser Gln His Ser Gly Met Ile Gly Tyr Glu Thr Asp Glu 
        435                 440                 445             


Asp Arg Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala 
    450                 455                 460                 


Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr 
465                 470                 475                 480 


Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His 
                485                 490                 495     


Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His 
            500                 505                 510         


Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu 
        515                 520                 525             


Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu 
    530                 535                 540                 


Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu 
545                 550                 555                 560 


Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys 
                565                 570                 575     


Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser 
            580                 585                 590         


Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu 
        595                 600                 605             


His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro 
    610                 615                 620                 


Cys Lys Ile Pro Val Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro 
625                 630                 635                 640 


Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu 
                645                 650                 655     


Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr 
            660                 665                 670         


Ile Val Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg 
        675                 680                 685             


Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala 
    690                 695                 700                 


Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val 
705                 710                 715                 720 


Gly Gly Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly 
                725                 730                 735     


Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile 
            740                 745                 750         


Leu Ile Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly 
        755                 760                 765             


Ser Ile Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu 
    770                 775                 780                 


Ser Thr Ala Val Ser Ala Asp Val Gly Cys Ser Val Asp Phe Ser Lys 
785                 790                 795                 800 


Lys Glu Thr Arg Cys Gly Thr Gly Val Phe Ile Tyr Asn Asp Val Glu 
                805                 810                 815     


Ala Trp Arg Asp Arg Tyr Lys Tyr His Pro Asp Ser Pro Arg Arg Leu 
            820                 825                 830         


Ala Ala Ala Val Lys Gln Ala Trp Glu Glu Gly Ile Cys Gly Ile Ser 
        835                 840                 845             


Ser Val Ser Arg Met Glu Asn Ile Met Trp Lys Ser Val Glu Gly Glu 
    850                 855                 860                 


Leu Asn Ala Ile Leu Glu Glu Asn Gly Val Gln Leu Thr Val Val Val 
865                 870                 875                 880 


Gly Ser Val Lys Asn Pro Met Trp Arg Gly Pro Gln Arg Leu Pro Val 
                885                 890                 895     


Pro Val Asn Glu Leu Pro His Gly Trp Lys Ala Trp Gly Lys Ser Tyr 
            900                 905                 910         


Phe Val Arg Ala Ala Lys Thr Asn Asn Ser Phe Val Val Asp Gly Asp 
        915                 920                 925             


Thr Leu Lys Glu Cys Pro Leu Glu His Arg Ala Trp Asn Ser Phe Leu 
    930                 935                 940                 


Val Glu Asp His Gly Phe Gly Val Phe His Thr Ser Val Trp Leu Lys 
945                 950                 955                 960 


Val Arg Glu Asp Tyr Ser Leu Glu Cys Asp Pro Ala Val Ile Gly Thr 
                965                 970                 975     


Ala Val Lys Gly Arg Glu Ala Ala His Ser Asp Leu Gly Tyr Trp Ile 
            980                 985                 990         


Glu Ser Glu Lys Asn Asp Thr Trp  Arg Leu Lys Arg Ala  His Leu Ile 
        995                 1000                 1005             


Glu Met  Lys Thr Cys Glu Trp  Pro Lys Ser His Thr  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Val Glu Glu Ser Asp  Leu Ile Ile Pro Lys  Ser Leu Ala 
    1025                 1030                 1035             


Gly Pro  Leu Ser His His Asn  Thr Arg Glu Gly Tyr  Arg Thr Gln 
    1040                 1045                 1050             


Val Lys  Gly Pro Trp His Ser  Glu Glu Leu Glu Ile  Arg Phe Glu 
    1055                 1060                 1065             


Glu Cys  Pro Gly Thr Lys Val  Tyr Val Glu Glu Thr  Cys Gly Thr 
    1070                 1075                 1080             


Arg Gly  Pro Ser Leu Arg Ser  Thr Thr Ala Ser Gly  Arg Val Ile 
    1085                 1090                 1095             


Glu Glu  Trp Cys Cys Arg Glu  Cys Thr Met Pro Pro  Leu Ser Phe 
    1100                 1105                 1110             


Arg Ala  Lys Asp Gly Cys Trp  Tyr Gly Met Glu Ile  Arg Pro Arg 
    1115                 1120                 1125             


Lys Glu  Pro Glu Ser Asn Leu  Val Arg Ser Met Val  Thr Ala Gly 
    1130                 1135                 1140             


Ser Thr  Asp His Met Asp His  Phe Ser Leu Gly Val  Leu Val Ile 
    1145                 1150                 1155             


Leu Leu  Met Val Gln Glu Gly  Leu Lys Lys Arg Met  Thr Thr Lys 
    1160                 1165                 1170             


Ile Ile  Met Ser Thr Ser Met  Ala Val Leu Val Val  Met Ile Leu 
    1175                 1180                 1185             


Gly Gly  Phe Ser Met Ser Asp  Leu Ala Lys Leu Val  Ile Leu Met 
    1190                 1195                 1200             


Gly Ala  Thr Phe Ala Glu Met  Asn Thr Gly Gly Asp  Val Ala His 
    1205                 1210                 1215             


Leu Ala  Leu Val Ala Ala Phe  Lys Val Arg Pro Ala  Leu Leu Val 
    1220                 1225                 1230             


Ser Phe  Ile Phe Arg Ala Asn  Trp Thr Pro Arg Glu  Ser Met Leu 
    1235                 1240                 1245             


Leu Ala  Leu Ala Ser Cys Leu  Leu Gln Thr Ala Ile  Ser Ala Leu 
    1250                 1255                 1260             


Glu Gly  Asp Leu Met Val Leu  Ile Asn Gly Phe Ala  Leu Ala Trp 
    1265                 1270                 1275             


Leu Ala  Ile Arg Ala Met Ala  Val Pro Arg Thr Asp  Asn Ile Ala 
    1280                 1285                 1290             


Leu Pro  Ile Leu Ala Ala Leu  Thr Pro Leu Ala Arg  Gly Thr Leu 
    1295                 1300                 1305             


Leu Val  Ala Trp Arg Ala Gly  Leu Ala Thr Cys Gly  Gly Ile Met 
    1310                 1315                 1320             


Leu Leu  Ser Leu Lys Gly Lys  Gly Ser Val Lys Lys  Asn Leu Pro 
    1325                 1330                 1335             


Phe Val  Met Ala Leu Gly Leu  Thr Ala Val Arg Val  Val Asp Pro 
    1340                 1345                 1350             


Ile Asn  Val Val Gly Leu Leu  Leu Leu Thr Arg Ser  Gly Lys Arg 
    1355                 1360                 1365             


Ser Trp  Pro Pro Ser Glu Val  Leu Thr Ala Val Gly  Leu Ile Cys 
    1370                 1375                 1380             


Ala Leu  Ala Gly Gly Phe Ala  Lys Ala Asp Ile Glu  Met Ala Gly 
    1385                 1390                 1395             


Pro Met  Ala Ala Val Gly Leu  Leu Ile Val Ser Tyr  Val Val Ser 
    1400                 1405                 1410             


Gly Lys  Ser Val Asp Met Tyr  Ile Glu Arg Ala Gly  Asp Ile Thr 
    1415                 1420                 1425             


Trp Glu  Lys Asp Ala Glu Val  Thr Gly Asn Ser Pro  Arg Leu Asp 
    1430                 1435                 1440             


Val Ala  Leu Asp Glu Ser Gly  Asp Phe Ser Leu Val  Glu Glu Asp 
    1445                 1450                 1455             


Gly Pro  Pro Met Arg Glu Ile  Ile Leu Lys Val Val  Leu Met Ala 
    1460                 1465                 1470             


Ile Cys  Gly Met Asn Pro Ile  Ala Ile Pro Phe Ala  Ala Gly Ala 
    1475                 1480                 1485             


Trp Tyr  Val Tyr Val Lys Thr  Gly Lys Arg Ser Gly  Ala Leu Trp 
    1490                 1495                 1500             


Asp Val  Pro Ala Pro Lys Glu  Val Lys Lys Gly Glu  Thr Thr Asp 
    1505                 1510                 1515             


Gly Val  Tyr Arg Val Met Thr  Arg Arg Leu Leu Gly  Ser Thr Gln 
    1520                 1525                 1530             


Val Gly  Val Gly Val Met Gln  Glu Gly Val Phe His  Thr Met Trp 
    1535                 1540                 1545             


His Val  Thr Lys Gly Ala Ala  Leu Arg Ser Gly Glu  Gly Arg Leu 
    1550                 1555                 1560             


Asp Pro  Tyr Trp Gly Asp Val  Lys Gln Asp Leu Val  Ser Tyr Cys 
    1565                 1570                 1575             


Gly Pro  Trp Lys Leu Asp Ala  Ala Trp Asp Gly Leu  Ser Glu Val 
    1580                 1585                 1590             


Gln Leu  Leu Ala Val Pro Pro  Gly Glu Arg Ala Arg  Asn Ile Gln 
    1595                 1600                 1605             


Thr Leu  Pro Gly Ile Phe Lys  Thr Lys Asp Gly Asp  Ile Gly Ala 
    1610                 1615                 1620             


Val Ala  Leu Asp Tyr Pro Ala  Gly Thr Ser Gly Ser  Pro Ile Leu 
    1625                 1630                 1635             


Asp Lys  Cys Gly Arg Val Ile  Gly Leu Tyr Gly Asn  Gly Val Val 
    1640                 1645                 1650             


Ile Lys  Asn Gly Ser Tyr Val  Ser Ala Ile Thr Gln  Gly Lys Arg 
    1655                 1660                 1665             


Glu Glu  Glu Thr Pro Val Glu  Cys Phe Glu Pro Ser  Met Leu Lys 
    1670                 1675                 1680             


Lys Lys  Gln Leu Thr Val Leu  Asp Leu His Pro Gly  Ala Gly Lys 
    1685                 1690                 1695             


Thr Arg  Arg Val Leu Pro Glu  Ile Val Arg Glu Ala  Ile Lys Lys 
    1700                 1705                 1710             


Arg Leu  Arg Thr Val Ile Leu  Ala Pro Thr Arg Val  Val Ala Ala 
    1715                 1720                 1725             


Glu Met  Glu Glu Ala Leu Arg  Gly Leu Pro Val Arg  Tyr Met Thr 
    1730                 1735                 1740             


Thr Ala  Val Asn Val Thr His  Ser Gly Thr Glu Ile  Val Asp Leu 
    1745                 1750                 1755             


Met Cys  His Ala Thr Phe Thr  Ser Arg Leu Leu Gln  Pro Ile Arg 
    1760                 1765                 1770             


Val Pro  Asn Tyr Asn Leu Asn  Ile Met Asp Glu Ala  His Phe Thr 
    1775                 1780                 1785             


Asp Pro  Ser Ser Ile Ala Ala  Arg Gly Tyr Ile Ser  Thr Arg Val 
    1790                 1795                 1800             


Glu Met  Gly Glu Ala Ala Ala  Ile Phe Met Thr Ala  Thr Pro Pro 
    1805                 1810                 1815             


Gly Thr  Arg Asp Ala Phe Pro  Asp Ser Asn Ser Pro  Ile Met Asp 
    1820                 1825                 1830             


Thr Glu  Val Glu Val Pro Glu  Arg Ala Trp Ser Ser  Gly Phe Asp 
    1835                 1840                 1845             


Trp Val  Thr Asp His Ser Gly  Lys Thr Val Trp Phe  Val Pro Ser 
    1850                 1855                 1860             


Val Arg  Asn Gly Asn Glu Ile  Ala Ala Cys Leu Thr  Lys Ala Gly 
    1865                 1870                 1875             


Lys Arg  Val Ile Gln Leu Ser  Arg Lys Thr Phe Glu  Thr Glu Phe 
    1880                 1885                 1890             


Gln Lys  Thr Lys Asn Gln Glu  Trp Asp Phe Val Ile  Thr Thr Asp 
    1895                 1900                 1905             


Ile Ser  Glu Met Gly Ala Asn  Phe Lys Ala Asp Arg  Val Ile Asp 
    1910                 1915                 1920             


Ser Arg  Arg Cys Leu Lys Pro  Val Ile Leu Asp Gly  Glu Arg Val 
    1925                 1930                 1935             


Ile Leu  Ala Gly Pro Met Pro  Val Thr His Ala Ser  Ala Ala Gln 
    1940                 1945                 1950             


Arg Arg  Gly Arg Ile Gly Arg  Asn Pro Asn Lys Pro  Gly Asp Glu 
    1955                 1960                 1965             


Tyr Met  Tyr Gly Gly Gly Cys  Ala Glu Thr Asp Glu  Gly His Ala 
    1970                 1975                 1980             


His Trp  Leu Glu Ala Arg Met  Leu Leu Asp Asn Ile  Tyr Leu Gln 
    1985                 1990                 1995             


Asp Gly  Leu Ile Ala Ser Leu  Tyr Arg Pro Glu Ala  Asp Lys Val 
    2000                 2005                 2010             


Ala Ala  Ile Glu Gly Glu Phe  Lys Leu Arg Thr Glu  Gln Arg Lys 
    2015                 2020                 2025             


Thr Phe  Val Glu Leu Met Lys  Arg Gly Asp Leu Pro  Val Trp Leu 
    2030                 2035                 2040             


Ala Tyr  Gln Val Ala Ser Ala  Gly Ile Thr Tyr Thr  Asp Arg Arg 
    2045                 2050                 2055             


Trp Cys  Phe Asp Gly Thr Thr  Asn Asn Thr Ile Met  Glu Asp Ser 
    2060                 2065                 2070             


Val Pro  Ala Glu Val Trp Thr  Lys Tyr Gly Glu Lys  Arg Val Leu 
    2075                 2080                 2085             


Lys Pro  Arg Trp Met Asp Ala  Arg Val Cys Ser Asp  His Ala Ala 
    2090                 2095                 2100             


Leu Lys  Ser Phe Lys Glu Phe  Ala Ala Gly Lys Arg  Gly Ala Ala 
    2105                 2110                 2115             


Leu Gly  Val Met Glu Ala Leu  Gly Thr Leu Pro Gly  His Met Thr 
    2120                 2125                 2130             


Glu Arg  Phe Gln Glu Ala Ile  Asp Asn Leu Ala Val  Leu Met Arg 
    2135                 2140                 2145             


Ala Glu  Thr Gly Ser Arg Pro  Tyr Lys Ala Ala Ala  Ala Gln Leu 
    2150                 2155                 2160             


Pro Glu  Thr Leu Glu Thr Ile  Met Leu Leu Gly Leu  Leu Gly Thr 
    2165                 2170                 2175             


Val Ser  Leu Gly Ile Phe Phe  Val Leu Met Arg Asn  Lys Gly Ile 
    2180                 2185                 2190             


Gly Lys  Met Gly Phe Gly Met  Val Thr Leu Gly Ala  Ser Ala Trp 
    2195                 2200                 2205             


Leu Met  Trp Leu Ser Glu Ile  Glu Pro Ala Arg Ile  Ala Cys Val 
    2210                 2215                 2220             


Leu Ile  Val Val Phe Leu Leu  Leu Val Val Leu Ile  Pro Glu Pro 
    2225                 2230                 2235             


Glu Lys  Gln Arg Ser Pro Gln  Asp Asn Gln Met Ala  Ile Ile Ile 
    2240                 2245                 2250             


Met Val  Ala Val Gly Leu Leu  Gly Leu Ile Thr Ala  Asn Glu Leu 
    2255                 2260                 2265             


Gly Trp  Leu Glu Arg Thr Lys  Asn Asp Ile Ala His  Leu Met Gly 
    2270                 2275                 2280             


Arg Arg  Glu Glu Gly Ala Thr  Met Gly Phe Ser Met  Asp Ile Asp 
    2285                 2290                 2295             


Leu Arg  Pro Ala Ser Ala Trp  Ala Ile Tyr Ala Ala  Leu Thr Thr 
    2300                 2305                 2310             


Leu Ile  Thr Pro Ala Val Gln  His Ala Val Thr Thr  Ser Tyr Asn 
    2315                 2320                 2325             


Asn Tyr  Ser Leu Met Ala Met  Ala Thr Gln Ala Gly  Val Leu Phe 
    2330                 2335                 2340             


Gly Met  Gly Lys Gly Met Pro  Phe Met His Gly Asp  Leu Gly Val 
    2345                 2350                 2355             


Pro Leu  Leu Met Met Gly Cys  Tyr Ser Gln Leu Thr  Pro Leu Thr 
    2360                 2365                 2370             


Leu Ile  Val Ala Ile Ile Leu  Leu Val Ala His Tyr  Met Tyr Leu 
    2375                 2380                 2385             


Ile Pro  Gly Leu Gln Ala Ala  Ala Ala Arg Ala Ala  Gln Lys Arg 
    2390                 2395                 2400             


Thr Ala  Ala Gly Ile Met Lys  Asn Pro Val Val Asp  Gly Ile Val 
    2405                 2410                 2415             


Val Thr  Asp Ile Asp Thr Met  Thr Ile Asp Pro Gln  Val Glu Lys 
    2420                 2425                 2430             


Lys Met  Gly Gln Val Leu Leu  Ile Ala Val Ala Ile  Ser Ser Ala 
    2435                 2440                 2445             


Val Leu  Leu Arg Thr Ala Trp  Gly Trp Gly Glu Ala  Gly Ala Leu 
    2450                 2455                 2460             


Ile Thr  Ala Ala Thr Ser Thr  Leu Trp Glu Gly Ser  Pro Asn Lys 
    2465                 2470                 2475             


Tyr Trp  Asn Ser Ser Thr Ala  Thr Ser Leu Cys Asn  Ile Phe Arg 
    2480                 2485                 2490             


Gly Ser  Tyr Leu Ala Gly Ala  Ser Leu Ile Tyr Thr  Val Thr Arg 
    2495                 2500                 2505             


Asn Ala  Gly Leu Val Lys Arg  Arg Gly Gly Gly Thr  Gly Glu Thr 
    2510                 2515                 2520             


Leu Gly  Glu Lys Trp Lys Ala  Arg Leu Asn Gln Met  Ser Ala Leu 
    2525                 2530                 2535             


Glu Phe  Tyr Ser Tyr Lys Lys  Ser Gly Ile Thr Glu  Val Cys Arg 
    2540                 2545                 2550             


Glu Glu  Ala Arg Arg Ala Leu  Lys Asp Gly Val Ala  Thr Gly Gly 
    2555                 2560                 2565             


His Ala  Val Ser Arg Gly Ser  Ala Lys Ile Arg Trp  Leu Glu Glu 
    2570                 2575                 2580             


Arg Gly  Tyr Leu Gln Pro Tyr  Gly Lys Val Val Asp  Leu Gly Cys 
    2585                 2590                 2595             


Gly Arg  Gly Gly Trp Ser Tyr  Tyr Ala Ala Thr Ile  Arg Lys Val 
    2600                 2605                 2610             


Gln Glu  Val Arg Gly Tyr Thr  Lys Gly Gly Pro Gly  His Glu Glu 
    2615                 2620                 2625             


Pro Met  Leu Val Gln Ser Tyr  Gly Trp Asn Ile Val  Arg Leu Lys 
    2630                 2635                 2640             


Ser Gly  Val Asp Val Phe His  Met Ala Ala Glu Pro  Cys Asp Thr 
    2645                 2650                 2655             


Leu Leu  Cys Asp Ile Gly Glu  Ser Ser Ser Ser Pro  Glu Val Glu 
    2660                 2665                 2670             


Glu Thr  Arg Thr Leu Arg Val  Leu Ser Met Val Gly  Asp Trp Leu 
    2675                 2680                 2685             


Glu Lys  Arg Pro Gly Ala Phe  Cys Ile Lys Val Leu  Cys Pro Tyr 
    2690                 2695                 2700             


Thr Ser  Thr Met Met Glu Thr  Met Glu Arg Leu Gln  Arg Arg His 
    2705                 2710                 2715             


Gly Gly  Gly Leu Val Arg Val  Pro Leu Cys Arg Asn  Ser Thr His 
    2720                 2725                 2730             


Glu Met  Tyr Trp Val Ser Gly  Ala Lys Ser Asn Ile  Ile Lys Ser 
    2735                 2740                 2745             


Val Ser  Thr Thr Ser Gln Leu  Leu Leu Gly Arg Met  Asp Gly Pro 
    2750                 2755                 2760             


Arg Arg  Pro Val Lys Tyr Glu  Glu Asp Val Asn Leu  Gly Ser Gly 
    2765                 2770                 2775             


Thr Arg  Ala Val Ala Ser Cys  Ala Glu Ala Pro Asn  Met Lys Ile 
    2780                 2785                 2790             


Ile Gly  Arg Arg Ile Glu Arg  Ile Arg Asn Glu His  Ala Glu Thr 
    2795                 2800                 2805             


Trp Phe  Leu Asp Glu Asn His  Pro Tyr Arg Thr Trp  Ala Tyr His 
    2810                 2815                 2820             


Gly Ser  Tyr Glu Ala Pro Thr  Gln Gly Ser Ala Ser  Ser Leu Val 
    2825                 2830                 2835             


Asn Gly  Val Val Arg Leu Leu  Ser Lys Pro Trp Asp  Val Val Thr 
    2840                 2845                 2850             


Gly Val  Thr Gly Ile Ala Met  Thr Asp Thr Thr Pro  Tyr Gly Gln 
    2855                 2860                 2865             


Gln Arg  Val Phe Lys Glu Lys  Val Asp Thr Arg Val  Pro Asp Pro 
    2870                 2875                 2880             


Gln Glu  Gly Thr Arg Gln Val  Met Asn Ile Val Ser  Ser Trp Leu 
    2885                 2890                 2895             


Trp Lys  Glu Leu Gly Lys Arg  Lys Arg Pro Arg Val  Cys Thr Lys 
    2900                 2905                 2910             


Glu Glu  Phe Ile Asn Lys Val  Arg Ser Asn Ala Ala  Leu Gly Ala 
    2915                 2920                 2925             


Ile Phe  Glu Glu Glu Lys Glu  Trp Lys Thr Ala Val  Glu Ala Val 
    2930                 2935                 2940             


Asn Asp  Pro Arg Phe Trp Ala  Leu Val Asp Arg Glu  Arg Glu His 
    2945                 2950                 2955             


His Leu  Arg Gly Glu Cys His  Ser Cys Val Tyr Asn  Met Met Gly 
    2960                 2965                 2970             


Lys Arg  Glu Lys Lys Gln Gly  Glu Phe Gly Lys Ala  Lys Gly Ser 
    2975                 2980                 2985             


Arg Ala  Ile Trp Tyr Met Trp  Leu Gly Ala Arg Phe  Leu Glu Phe 
    2990                 2995                 3000             


Glu Ala  Leu Gly Phe Leu Asn  Glu Asp His Trp Met  Gly Arg Glu 
    3005                 3010                 3015             


Asn Ser  Gly Gly Gly Val Glu  Gly Leu Gly Leu Gln  Arg Leu Gly 
    3020                 3025                 3030             


Tyr Ile  Leu Glu Glu Met Asn  Arg Ala Pro Gly Gly  Lys Met Tyr 
    3035                 3040                 3045             


Ala Asp  Asp Thr Ala Gly Trp  Asp Thr Arg Ile Ser  Lys Phe Asp 
    3050                 3055                 3060             


Leu Glu  Asn Glu Ala Leu Ile  Thr Asn Gln Met Glu  Glu Gly His 
    3065                 3070                 3075             


Arg Thr  Leu Ala Leu Ala Val  Ile Lys Tyr Thr Tyr  Gln Asn Lys 
    3080                 3085                 3090             


Val Val  Lys Val Leu Arg Pro  Ala Glu Gly Gly Lys  Thr Val Met 
    3095                 3100                 3105             


Asp Ile  Ile Ser Arg Gln Asp  Gln Arg Gly Ser Gly  Gln Val Val 
    3110                 3115                 3120             


Thr Tyr  Ala Leu Asn Thr Phe  Thr Asn Leu Val Val  Gln Leu Ile 
    3125                 3130                 3135             


Arg Asn  Met Glu Ala Glu Glu  Val Leu Glu Met Gln  Asp Leu Trp 
    3140                 3145                 3150             


Leu Leu  Arg Lys Pro Glu Lys  Val Thr Arg Trp Leu  Gln Ser Asn 
    3155                 3160                 3165             


Gly Trp  Asp Arg Leu Lys Arg  Met Ala Val Ser Gly  Asp Asp Cys 
    3170                 3175                 3180             


Val Val  Lys Pro Ile Asp Asp  Arg Phe Ala His Ala  Leu Arg Phe 
    3185                 3190                 3195             


Leu Asn  Asp Met Gly Lys Val  Arg Lys Asp Thr Gln  Glu Trp Lys 
    3200                 3205                 3210             


Pro Ser  Thr Gly Trp Ser Asn  Trp Glu Glu Val Pro  Phe Cys Ser 
    3215                 3220                 3225             


His His  Phe Asn Lys Leu Tyr  Leu Lys Asp Gly Arg  Ser Ile Val 
    3230                 3235                 3240             


Val Pro  Cys Arg His Gln Asp  Glu Leu Ile Gly Arg  Ala Arg Val 
    3245                 3250                 3255             


Ser Pro  Gly Ala Gly Trp Ser  Ile Arg Glu Thr Ala  Cys Leu Ala 
    3260                 3265                 3270             


Lys Ser  Tyr Ala Gln Met Trp  Gln Leu Leu Tyr Phe  His Arg Arg 
    3275                 3280                 3285             


Asp Leu  Arg Leu Met Ala Asn  Ala Ile Cys Ser Ala  Val Pro Val 
    3290                 3295                 3300             


Asp Trp  Val Pro Thr Gly Arg  Thr Thr Trp Ser Ile  His Gly Lys 
    3305                 3310                 3315             


Gly Glu  Trp Met Thr Thr Glu  Asp Met Leu Met Val  Trp Asn Arg 
    3320                 3325                 3330             


Val Trp  Ile Glu Glu Asn Asp  His Met Glu Asp Lys  Thr Pro Val 
    3335                 3340                 3345             


Thr Lys  Trp Thr Asp Ile Pro  Tyr Leu Gly Lys Arg  Glu Asp Leu 
    3350                 3355                 3360             


Trp Cys  Gly Ser Leu Ile Gly  His Arg Pro Arg Thr  Thr Trp Ala 
    3365                 3370                 3375             


Glu Asn  Ile Lys Asp Thr Val  Asn Met Val Arg Arg  Ile Ile Gly 
    3380                 3385                 3390             


Asp Glu  Glu Lys Tyr Met Asp  Tyr Leu Ser Thr Gln  Val Arg Tyr 
    3395                 3400                 3405             


Leu Gly  Glu Glu Gly Ser Thr  Pro Gly Val Leu 
    3410                 3415                 


<210>  16
<211>  504
<212>  PRT
<213>  Zika virus

<400>  16

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys 
        115                 120                 125             


Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His 
    130                 135                 140                 


Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr 
145                 150                 155                 160 


Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala 
                165                 170                 175     


Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
            180                 185                 190         


Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
        195                 200                 205             


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
    210                 215                 220                 


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
225                 230                 235                 240 


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
                245                 250                 255     


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
            260                 265                 270         


Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His 
        275                 280                 285             


Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser 
    290                 295                 300                 


Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu 
305                 310                 315                 320 


Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp 
                325                 330                 335     


Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu 
            340                 345                 350         


Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser 
        355                 360                 365             


Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp 
    370                 375                 380                 


Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp 
385                 390                 395                 400 


His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg 
                405                 410                 415     


Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly 
            420                 425                 430         


Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile 
        435                 440                 445             


Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser 
    450                 455                 460                 


Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys 
465                 470                 475                 480 


Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile 
                485                 490                 495     


Phe Leu Ser Thr Ala Val Ser Ala 
            500                 


<210>  17
<211>  51
<212>  PRT
<213>  ZIKV ED1

<400>  17

Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser 
1               5                   10                  15      


Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr 
        35                  40                  45              


Thr Val Ser 
    50      


<210>  18
<211>  61
<212>  PRT
<213>  ZIKV ED1

<400>  18

Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln 
1               5                   10                  15      


His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn 
            20                  25                  30          


Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr 
        35                  40                  45              


Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro 
    50                  55                  60      


<210>  19
<211>  16
<212>  PRT
<213>  ZIKV ED1

<400>  19

Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg Leu Lys Met 
1               5                   10                  15      


<210>  20
<211>  80
<212>  PRT
<213>  ZIKV ED2

<400>  20

Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp 
1               5                   10                  15      


Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp 
            20                  25                  30          


Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg 
        35                  40                  45              


Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr 
    50                  55                  60                  


Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln 
65                  70                  75                  80  


<210>  21
<211>  87
<212>  PRT
<213>  ZIKV ED2

<400>  21

Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn 
1               5                   10                  15      


Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro 
            20                  25                  30          


Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu 
        35                  40                  45              


Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val 
    50                  55                  60                  


Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala 
65                  70                  75                  80  


Leu Glu Ala Glu Met Asp Gly 
                85          


<210>  22
<211>  108
<212>  PRT
<213>  ZIKV ED3

<400>  22

Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala 
1               5                   10                  15      


Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly Thr Val Thr 
            20                  25                  30          


Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala 
        35                  40                  45              


Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile 
    50                  55                  60                  


Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met 
65                  70                  75                  80  


Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val 
                85                  90                  95      


Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser 
            100                 105             


<210>  23
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Thr Gly Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Phe Trp Arg Ser Gly Arg Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val 
    


<210>  24
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr His Phe Asp Ile Val Asp Tyr 
            20                  25                  30          


Asp Tyr Leu Ser Trp Tyr Gln Gln His Pro Gly Asn Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Val Ser Asn Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Ser Ser Tyr Ser Ile Ser 
                85                  90                  95      


Ser Thr Leu Leu Val 
            100     


<210>  25
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ala Phe Ser Asn Tyr His 
            20                  25                  30          


His His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Ile Ile Trp Asp Asp Gly Ser Asp Gln Tyr Tyr Asp Ser Tyr Lys Gln 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln 
65                  70                  75                  80  


Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Val Gly 
                85                  90                  95      


Gly Ser Ser Ala Tyr Asn Gly Asp Asn Gly Trp Arg Glu Ala Ala Ser 
            100                 105                 110         


Leu Asp Asp 
        115 


<210>  26
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Phe Cys Ser Gly Ser Ser Asn Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Asn Ser Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Arg 
                85                  90                  95      


Arg Thr Trp Val 
            100 


