               SEQUENCE LISTING

<110> c-LEcta GmbH  New Matterhorn  LLC

<120> Sucrose phosphorylase

<130> C71261PC

<160> 18

<170> BiSSAP 1.3.6

<210> 1
<211> 504
<212> PRT
<213> Bifidobacterium magnum


<220> 
<223> wild-type

<400> 1
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 2
<211> 504
<212> PRT
<213> Bifidobacterium longum


<220> 
<223> wild-type

<400> 2
Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asp Arg Leu Gly Asp 
1               5                   10                  15      
Gly Thr Leu Ser Ser Met Thr Asp Ile Leu Arg Thr Arg Phe Asp Gly 
            20                  25                  30          
Val Tyr Asp Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Gly Trp Asp Asp Val Ala Glu Leu Ser Lys Thr His Gly Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Lys Gln Phe 
                85                  90                  95      
Gln Asp Val Leu Glu Lys Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Asn Gly Ala Thr Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Lys 
    130                 135                 140                 
Phe Ala Gly Lys Thr Arg Leu Val Trp Val Ser Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ala Ala Ser His Val Ser Tyr Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Lys Leu Ile Ser Arg Leu Arg Glu Glu Gly Val Lys 
    210                 215                 220                 
Arg Gly Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Val Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Asn Thr Gly His Val Glu Pro Val Ala 
            260                 265                 270         
His Trp Thr Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Leu Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Pro Asp Glu Asp Val Asp Asn Leu Val Asn 
305                 310                 315                 320 
Ala Ile His Ala Asn Thr His Gly Glu Ser Gln Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Ser Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln His Tyr Ile Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Lys Asn Asp Met Glu Leu Leu Arg Lys Thr Asn Asn Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Thr Ala Glu Ile Asp Glu Asn Leu Gln 
                405                 410                 415     
Arg Pro Val Val Lys Ala Leu Asn Ala Leu Ala Lys Phe Arg Asn Glu 
            420                 425                 430         
Leu Asp Ala Phe Asp Gly Thr Phe Ser Tyr Ser Ala Asp Gly Asp Thr 
        435                 440                 445             
Ser Ile Ser Phe Thr Trp Glu Gly Thr Thr Thr Gln Ala Thr Leu Thr 
    450                 455                 460                 
Phe Glu Pro Gly Arg Gly Leu Gly Val Glu Asn Thr Ala Ser Val Ala 
465                 470                 475                 480 
Thr Leu Glu Trp Arg Asp Ala Ala Gly Glu His Arg Thr Asp Asp Leu 
                485                 490                 495     
Ile Ala Asn Pro Pro Val Val Ala 
            500                 

<210> 3
<211> 506
<212> PRT
<213> Bifidobacterium animalis


<220> 
<223> wild-type

<400> 3
Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asp Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Met Thr Asp Ile Leu Arg Thr Arg Phe Asp Gly 
            20                  25                  30          
Val Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Ala Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asp Asp Ile Ala Glu Leu Ala Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Gln Ser Lys Gln Phe 
                85                  90                  95      
Gln Asp Val Leu Ala Asn Gly Glu Asp Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Asp Gly Ala Thr Glu Glu Glu Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Ser 
    130                 135                 140                 
Phe Ala Gly Lys Thr Arg Leu Val Trp Val Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Ala Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Lys Tyr Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Glu Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Gly Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Val Glu Ile Ala Ala Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Lys Val Asp Ala Leu Ala 
            260                 265                 270         
His Trp Thr Glu Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Leu Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Pro Asp Ala Asp Val Asp Asn Met Val Glu 
305                 310                 315                 320 
Thr Ile Ala Lys Asn Thr His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Ser Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln His Tyr Ile Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Glu Asn Asp Met Glu Leu Leu Lys Arg Thr Asn Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Thr Thr Ser Glu Ile Asp Lys Asn Leu Glu 
                405                 410                 415     
Arg Pro Val Val Lys Ala Leu Asn Ala Leu Ala Arg Phe Arg Asn Glu 
            420                 425                 430         
Leu Pro Ala Phe Asp Gly Asp Phe Ser Tyr Ser Val Gly Asp Asp Glu 
        435                 440                 445             
Ser Ile Ala Phe Ser Trp Asn Gly Phe Gly Ser Ser Ala Thr Leu Thr 
    450                 455                 460                 
Phe Thr Pro Ser Lys Gly Met Gly Val Glu Asn Pro Gln Ser Val Ala 
465                 470                 475                 480 
Thr Leu Val Trp Thr Asp Ser Thr Gly Glu His Arg Thr Asp Asp Leu 
                485                 490                 495     
Ile Ala Asn Pro Pro Val Met Gln Ala Ser 
            500                 505     

<210> 4
<211> 503
<212> PRT
<213> Bifidobacterium thermophilum


<220> 
<223> wild-type

<400> 4
Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asn Arg Leu Gly Glu 
1               5                   10                  15      
Gly Thr Ile Lys Ser Leu Thr Asp Val Leu Arg Thr Arg Phe Asp Gly 
            20                  25                  30          
Val Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Val Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Thr Trp Asp Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Thr Ile Val Asn His Met Ser Trp Glu Ser Lys Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Arg Gly Glu Asp Ser Pro Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Asp Gly Ala Thr Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Thr 
    130                 135                 140                 
Trp Gly Gly Lys Thr Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Lys Glu Gly Trp Asp Tyr Leu Leu Ser 
                165                 170                 175     
Ile Leu Asp Gln Leu Ser Arg Ser His Val Ser Tyr Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Gln Ala Lys Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Asp Leu Ile Gly Arg Ile Lys Ala Glu Ala Glu Ser 
    210                 215                 220                 
Arg Gly Leu Glu Thr Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Val Ala Ile Ala Asn Lys Val Asp Arg Val Tyr Asp Phe Ala Ile Pro 
                245                 250                 255     
Gly Leu Leu Leu His Ala Leu Thr Thr Gly Lys Thr Glu Pro Ile Ala 
            260                 265                 270         
Lys Trp Val Glu Val Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Leu Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Pro Asp Glu Glu Val Asp Gln Leu Val Glu 
305                 310                 315                 320 
Thr Ile His Glu Asn Thr His Gly Glu Ser Arg Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Ser Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln His Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Ala Asn Asp Met Glu Leu Leu His Arg Thr Asn Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Glu Glu Ile Asp Arg Asn Leu Glu 
                405                 410                 415     
Arg Pro Val Val Lys Ala Leu Asn Ala Leu Cys Arg Met Arg Asn Gln 
            420                 425                 430         
Leu Asp Ala Phe Asp Gly Glu Phe Thr Phe Ser His Glu Gly Asp Thr 
        435                 440                 445             
Leu Thr Phe Asp Trp Lys Gly Glu Thr Thr Ser Ala Thr Leu Thr Phe 
    450                 455                 460                 
Glu Pro Lys Arg Gly Leu Gly Val Asp Asn Gln Ala Ser Val Cys Thr 
465                 470                 475                 480 
Leu Arg Trp Ser Asp Ala Ala Gly Glu His Glu Thr Asp Asp Leu Leu 
                485                 490                 495     
Ala Ala Pro Pro Thr Val Ala 
            500             

<210> 5
<211> 504
<212> PRT
<213> Bifidobacterium adolescentis


<220> 
<223> wild-type

<400> 5
Met Lys Asn Lys Val Gln Leu Ile Thr Tyr Ala Asp Arg Leu Gly Asp 
1               5                   10                  15      
Gly Thr Ile Lys Ser Met Thr Asp Ile Leu Arg Thr Arg Phe Asp Gly 
            20                  25                  30          
Val Tyr Asp Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Glu Arg 
    50                  55                  60                  
Leu Gly Ser Trp Asp Asp Val Ala Glu Leu Ser Lys Thr His Asn Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Lys Gln Phe 
                85                  90                  95      
Gln Asp Val Leu Ala Lys Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Asn Gly Ala Thr Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr His Tyr Lys 
    130                 135                 140                 
Phe Ala Gly Lys Thr Arg Leu Val Trp Val Ser Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ala Ala Ser His Val Ser Tyr Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Lys Leu Ile Ser Arg Leu Arg Glu Glu Gly Val Lys 
    210                 215                 220                 
Arg Gly Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Val Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ala Leu Ser Thr Gly His Val Glu Pro Val Ala 
            260                 265                 270         
His Trp Thr Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Leu Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Pro Asp Glu Asp Val Asp Asn Leu Val Asn 
305                 310                 315                 320 
Thr Ile His Ala Asn Thr His Gly Glu Ser Gln Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Ser Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln His Tyr Ile Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Lys Asn Asp Met Glu Leu Leu Arg Lys Thr Asn Asn Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Thr Ala Glu Ile Asp Glu Asn Leu Lys 
                405                 410                 415     
Arg Pro Val Val Lys Ala Leu Asn Ala Leu Ala Lys Phe Arg Asn Glu 
            420                 425                 430         
Leu Asp Ala Phe Asp Gly Thr Phe Ser Tyr Thr Thr Asp Asp Asp Thr 
        435                 440                 445             
Ser Ile Ser Phe Thr Trp Arg Gly Glu Thr Ser Gln Ala Thr Leu Thr 
    450                 455                 460                 
Phe Glu Pro Lys Arg Gly Leu Gly Val Asp Asn Thr Thr Pro Val Ala 
465                 470                 475                 480 
Met Leu Glu Trp Glu Asp Ser Ala Gly Asp His Arg Ser Asp Asp Leu 
                485                 490                 495     
Ile Ala Asn Pro Pro Val Val Ala 
            500                 

<210> 6
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >E92L

<400> 6
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Leu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 7
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >S124Q

<400> 7
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Gln Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 8
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >S124K

<400> 8
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Lys Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 9
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >S124T

<400> 9
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Thr Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 10
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >A148R

<400> 10
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Arg Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 11
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >A148K

<400> 11
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Lys Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 12
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >T157D

<400> 12
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Asp Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 13
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >Q188Y

<400> 13
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Tyr Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 14
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >I231V

<400> 14
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Val Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 15
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >L371A

<400> 15
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Ala Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 16
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >T461G

<400> 16
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Ala Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Gln Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Gly Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 17
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >A148K_Q188Y

<400> 17
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Lys Asn Arg Leu Val Trp Thr Thr Phe Thr Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Tyr Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Leu Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Thr Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

<210> 18
<211> 504
<212> PRT
<213> Artificial Sequence


<220> 
<223> >A148K_T157D_Q188Y_L371A_T461G

<400> 18
Met Lys Asn Lys Val Gln Met Ile Thr Tyr Ala Asn Arg Leu Gly Asp 
1               5                   10                  15      
Gly Asn Leu Ala Ser Leu Thr Glu Ile Leu Arg Thr Arg Phe Asn Gly 
            20                  25                  30          
Ala Tyr Glu Gly Val His Ile Leu Pro Phe Phe Thr Pro Phe Asp Gly 
        35                  40                  45              
Ala Asp Ala Gly Phe Asp Pro Ile Asp His Thr Lys Val Asp Pro Arg 
    50                  55                  60                  
Leu Gly Asp Trp Asn Asp Ile Ala Glu Leu Ser Lys Thr His Asp Ile 
65                  70                  75                  80  
Met Val Asp Ala Ile Val Asn His Met Ser Trp Glu Ser Ala Gln Phe 
                85                  90                  95      
Gln Asp Val Met Lys Asn Gly Glu Glu Ser Glu Tyr Tyr Pro Met Phe 
            100                 105                 110         
Leu Thr Met Ser Ser Val Phe Pro Leu Gly Ala Ser Glu Glu Asp Leu 
        115                 120                 125             
Ala Gly Ile Tyr Arg Pro Arg Pro Gly Leu Pro Phe Thr Pro Tyr Arg 
    130                 135                 140                 
Phe Gly Asn Lys Asn Arg Leu Val Trp Thr Thr Phe Asp Pro Gln Gln 
145                 150                 155                 160 
Val Asp Ile Asp Thr Asp Ser Asp Lys Gly Trp Glu Tyr Leu Met Ser 
                165                 170                 175     
Ile Phe Asp Gln Met Ser Lys Ser His Val Ser Tyr Ile Arg Leu Asp 
            180                 185                 190         
Ala Val Gly Tyr Gly Ala Lys Glu Ala Gly Thr Ser Cys Phe Met Thr 
        195                 200                 205             
Pro Lys Thr Phe Arg Leu Ile Ser Arg Leu Arg Glu Glu Gly Ala Lys 
    210                 215                 220                 
Arg Cys Leu Glu Ile Leu Ile Glu Val His Ser Tyr Tyr Lys Lys Gln 
225                 230                 235                 240 
Ile Glu Ile Ala Ser Lys Val Asp Arg Val Tyr Asp Phe Ala Leu Pro 
                245                 250                 255     
Pro Leu Leu Leu His Ser Leu Phe Thr Gly Asp Val Asp Ala Leu Ser 
            260                 265                 270         
His Trp Ile Asp Ile Arg Pro Asn Asn Ala Val Thr Val Leu Asp Thr 
        275                 280                 285             
His Asp Gly Ile Gly Val Ile Asp Ile Gly Ser Asp Gln Gln Asp Arg 
    290                 295                 300                 
Ser Leu Lys Gly Leu Val Ser Asp Glu Ala Val Asp Ala Leu Val Glu 
305                 310                 315                 320 
Lys Ile Ala Glu Asn Ser His Gly Glu Ser Lys Ala Ala Thr Gly Ala 
                325                 330                 335     
Ala Ala Ser Asn Leu Asp Leu Tyr Gln Val Asn Cys Thr Tyr Tyr Ser 
            340                 345                 350         
Ala Leu Gly Cys Asn Asp Gln Gln Tyr Leu Ala Ala Arg Ala Val Gln 
        355                 360                 365             
Phe Phe Ala Pro Gly Val Pro Gln Val Tyr Tyr Val Gly Ala Leu Ala 
    370                 375                 380                 
Gly Arg Asn Asp Met Thr Leu Leu Lys Glu Thr Gly Val Gly Arg Asp 
385                 390                 395                 400 
Ile Asn Arg His Tyr Tyr Ser Val Ala Glu Ile Asp Glu Asp Leu Lys 
                405                 410                 415     
Arg Pro Val Val Arg Ala Leu Asn Asp Leu Ala Lys Phe Arg Asn Asp 
            420                 425                 430         
Cys Pro Ala Phe Asp Gly Glu Phe Thr Trp Glu Arg Asp Gly Gln Asp 
        435                 440                 445             
Ser Val Thr Leu Thr Trp Thr Asn Gly Asp Ser His Gly Ser Leu Thr 
    450                 455                 460                 
Phe Gln Pro Asn Leu Gly Thr Gln Asp Ala Gly Ala Pro Val Ala Thr 
465                 470                 475                 480 
Leu Thr Trp Asn Asp Ala Asp Gly Glu His Thr Ser Ala Asp Leu Leu 
                485                 490                 495     
Thr Asn Pro Pro Val Tyr Arg Lys 
            500                 

