                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  NON-HUMAN ANIMALS COMPRISING A HUMANIZED TRKB LOCUS

<130>  57766-523380

<150>  US 62/592,905
<151>  2017-11-30

<150>  US 62/661,373
<151>  2018-04-23

<160>  125   

<170>  PatentIn version 3.5

<210>  1
<211>  821
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (32)..(429)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (430)..(453)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (454)..(821)
<223>  Cytoplasmic Domain

<400>  1

Met Ser Pro Trp Leu Lys Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Leu Cys Leu Leu Val Leu Gly Phe Trp Arg Ala Ser Leu Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ser Ala Arg Ile Trp Cys Thr Glu Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Leu Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala Tyr Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Arg His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Arg His Phe Arg His Leu Asp Leu Ser Asp Leu Ile 
    130                 135                 140                 


Leu Thr Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Leu Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Thr Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Met Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Arg Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Val Thr Leu Ser Cys Ser Val Gly Gly Asp Pro 
    210                 215                 220                 


Leu Pro Thr Leu Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Arg Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Met Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Arg Gln Ile Ser Ala His Phe Met Gly Arg Pro Gly Val 
    370                 375                 380                 


Asp Tyr Glu Thr Asn Pro Asn Tyr Pro Glu Val Leu Tyr Glu Asp Trp 
385                 390                 395                 400 


Thr Thr Pro Thr Asp Ile Gly Asp Thr Thr Asn Lys Ser Asn Glu Ile 
                405                 410                 415     


Pro Ser Thr Asp Val Ala Asp Gln Ser Asn Arg Glu His Leu Ser Val 
            420                 425                 430         


Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu Val 
        435                 440                 445             


Met Leu Leu Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met Lys 
    450                 455                 460                 


Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro Leu 
465                 470                 475                 480 


His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly Gly 
                485                 490                 495     


Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu Asn 
            500                 505                 510         


Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr Phe 
        515                 520                 525             


Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu Gly 
    530                 535                 540                 


Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Cys 
545                 550                 555                 560 


Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp Ala 
                565                 570                 575     


Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu Thr 
            580                 585                 590         


Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val Glu 
        595                 600                 605             


Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp Leu 
    610                 615                 620                 


Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala Glu 
625                 630                 635                 640 


Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile Ala 
                645                 650                 655     


Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe Val 
            660                 665                 670         


His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu Leu 
        675                 680                 685             


Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp 
    690                 695                 700                 


Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met Pro 
705                 710                 715                 720 


Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp 
                725                 730                 735     


Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro 
            740                 745                 750         


Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln Gly 
        755                 760                 765             


Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu Leu 
    770                 775                 780                 


Met Leu Gly Cys Trp Gln Arg Glu Pro His Thr Arg Lys Asn Ile Lys 
785                 790                 795                 800 


Ser Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val Tyr 
                805                 810                 815     


Leu Asp Ile Leu Gly 
            820     


<210>  2
<211>  821
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (32)..(429)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (430)..(453)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (454)..(821)
<223>  Cytoplasmic Domain

<400>  2

Met Ser Pro Trp Pro Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Leu Cys Leu Leu Val Leu Gly Phe Trp Arg Ala Ser Leu Ala Cys 
            20                  25                  30          


Pro Met Ser Cys Lys Cys Ser Thr Thr Arg Ile Trp Cys Thr Glu Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Ile Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Leu Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Lys Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala Tyr Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Gly Asn Leu Arg His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Arg His Phe Arg His Leu Asp Leu Ser Asp Leu Ile 
    130                 135                 140                 


Leu Thr Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Leu Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Thr Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Thr Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Arg Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Val Thr Ile Ser Cys Ser Val Gly Gly Asp Pro 
    210                 215                 220                 


Leu Pro Thr Leu Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Arg Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Met Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Arg Gln Ile Ser Ala His Phe Met Gly Arg Pro Gly Val 
    370                 375                 380                 


Asp Tyr Glu Thr Asn Pro Asn Tyr Pro Glu Val Leu Tyr Glu Asp Trp 
385                 390                 395                 400 


Thr Thr Pro Thr Asp Ile Gly Asp Thr Thr Asn Lys Ser Asn Glu Ile 
                405                 410                 415     


Pro Ser Thr Asp Val Ala Asp Gln Thr Asn Arg Glu His Leu Ser Val 
            420                 425                 430         


Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu Val 
        435                 440                 445             


Met Leu Leu Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met Lys 
    450                 455                 460                 


Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro Leu 
465                 470                 475                 480 


His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly Gly 
                485                 490                 495     


Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu Asn 
            500                 505                 510         


Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr Phe 
        515                 520                 525             


Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu Gly 
    530                 535                 540                 


Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Cys 
545                 550                 555                 560 


Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp Ala 
                565                 570                 575     


Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu Thr 
            580                 585                 590         


Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val Glu 
        595                 600                 605             


Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp Leu 
    610                 615                 620                 


Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala Glu 
625                 630                 635                 640 


Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile Ala 
                645                 650                 655     


Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe Val 
            660                 665                 670         


His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu Leu 
        675                 680                 685             


Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp 
    690                 695                 700                 


Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met Pro 
705                 710                 715                 720 


Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp 
                725                 730                 735     


Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro 
            740                 745                 750         


Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln Gly 
        755                 760                 765             


Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu Leu 
    770                 775                 780                 


Met Leu Gly Cys Trp Gln Arg Glu Pro His Thr Arg Lys Asn Ile Lys 
785                 790                 795                 800 


Asn Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val Tyr 
                805                 810                 815     


Leu Asp Ile Leu Gly 
            820     


<210>  3
<211>  838
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (32)..(430)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (431)..(454)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (455)..(838)
<223>  Cytoplasmic Domain

<400>  3

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
                565                 570                 575     


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
            580                 585                 590         


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
        595                 600                 605             


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
    610                 615                 620                 


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
                645                 650                 655     


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
            660                 665                 670         


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
        675                 680                 685             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
    690                 695                 700                 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
705                 710                 715                 720 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
                725                 730                 735     


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
            740                 745                 750         


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
        755                 760                 765             


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
    770                 775                 780                 


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
785                 790                 795                 800 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
                805                 810                 815     


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
            820                 825                 830         


Tyr Leu Asp Ile Leu Gly 
        835             


<210>  4
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Mouse Sequence

<220>
<221>  MISC_FEATURE
<222>  (32)..(430)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (32)..(432)
<223>  Human Sequence

<220>
<221>  MISC_FEATURE
<222>  (431)..(454)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (433)..(822)
<223>  Mouse Sequence

<220>
<221>  MISC_FEATURE
<222>  (455)..(822)
<223>  Cytoplasmic Domain

<400>  4

Met Ser Pro Trp Leu Lys Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Leu Cys Leu Leu Val Leu Gly Phe Trp Arg Ala Ser Leu Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Leu Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Thr Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Ser Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  5
<211>  822
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Rat Sequence

<220>
<221>  MISC_FEATURE
<222>  (32)..(430)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (32)..(432)
<223>  Human Sequence

<220>
<221>  MISC_FEATURE
<222>  (431)..(454)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (433)..(822)
<223>  Rat Sequence

<220>
<221>  MISC_FEATURE
<222>  (455)..(822)
<223>  Cytoplasmic Domain

<400>  5

Met Ser Pro Trp Pro Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Leu Cys Leu Leu Val Leu Gly Phe Trp Arg Ala Ser Leu Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Leu Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Thr Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Asn Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  6
<211>  8744
<212>  DNA
<213>  Mus musculus

<400>  6
gtctggaggg tgctatgcta tgcgtgtgtg cgtgtgtgtg cgcgcgcgcg tgtgtgagcg       60

tgtgtgtttt tggatttcat actaattttc tggagtttct gcccctgctc tgcgtcagcc      120

ctcacgtcac ttcgccagca gtagcagagg cggcggcggc ggcggccgcc ggttagagcc      180

cagtcgctgc ttcagctgct gttgctgctt ctgcagcgct ctgctccctg cgcttgctac      240

gggaggccgg ggaagccgcg cggacagtcc tcggtggcct gggccggcac tgtcctgcta      300

ccgcagttgc tccccagccc tgaggtgcgc accgatatcg atattcgtgc cggtttagcg      360

gttctgcgac ccaaagagtc cagggagatc caccgagtgg tgcctggcgt ataggactat      420

gcagccgcct tgtggctcgg agcagcggcc cgcgatgtcc cagccactgt gaaccatttg      480

gtcagcgcca acctgctcag ccccagcacc gacaggctca gcctctggta cgctccactc      540

cgcgggaggc caccagcacc aagcagcaag agggcgcagg gaaggcctcc cccctccggc      600

gggggacgcc tggctcagcg tagggacacg cactccgact gactggcact ggcagctcgg      660

gatgtcgccc tggctgaagt ggcatggacc cgccatggcg cggctctggg gcttatgcct      720

gctggtcttg ggcttctgga gggcctctct cgcctgcccg acgtcctgca aatgcagttc      780

cgctaggatt tggtgtactg agccttctcc aggcatcgtg gcattcccga ggttggaacc      840

taacagcgtt gacccggaga acatcacgga aattctcatt gcaaaccaga aaaggctaga      900

aatcatcaat gaagatgacg ttgaagctta cgtggggctg agaaacctta caattgtgga      960

ttccggctta aagtttgtgg cttacaaagc gtttctgaaa aacagcaacc tgcggcacat     1020

aaatttcaca cgaaacaagc tgacgagttt gtccaggaga catttccgcc accttgactt     1080

gtctgacctg atcctgacgg gtaatccgtt cacgtgctcc tgcgacatca tgtggctcaa     1140

gactctccag gagactaaat ccagccccga cactcaggat ttgtactgcc tcaatgagag     1200

cagcaagaac atgcccctgg cgaacctgca gatacccaat tgtggtctgc catctgcacg     1260

tctggctgct cctaacctca ccgtggagga aggaaagtct gtgacccttt cctgcagtgt     1320

ggggggtgac ccactcccca ccttgtactg ggacgttggg aatttggttt ccaagcacat     1380

gaatgaaaca agccacacac agggctcctt aaggataacg aacatttcat ctgatgacag     1440

tggaaagcaa atctcttgtg tggcagaaaa ccttgtagga gaagatcaag attctgtgaa     1500

cctcactgtg cattttgcgc caactatcac gtttctcgag tctccaacct cagatcacca     1560

ctggtgcatt ccattcactg tgagaggcaa ccccaagcct gcgcttcagt ggttctacaa     1620

tggggccata ctgaatgagt ccaagtacat ctgtactaag atccacgtca ccaatcacac     1680

ggagtaccat ggctgcctcc agctggataa ccccactcat atgaataacg gagactacac     1740

cctgatggcc aagaacgagt atgggaagga tgagagacag atctccgctc acttcatggg     1800

ccggcctgga gtcgactacg agacaaaccc aaattaccct gaagtcctct atgaagactg     1860

gaccacgcca actgacattg gggatactac gaacaaaagt aatgaaatcc cctccacgga     1920

tgttgctgac caaagcaatc gggagcatct ctcggtctat gccgtggtgg tgattgcatc     1980

tgtggtggga ttctgcctgc tggtgatgtt gctcctgctc aagttggcga gacattccaa     2040

gtttggcatg aaaggcccag cttcggtcat cagcaacgac gatgactctg ccagccccct     2100

ccaccacatc tccaatggga gtaacactcc atcttcttcg gagggcggtc ccgacgctgt     2160

cattattgga atgaccaaga ttcctgttat tgaaaacccc cagtactttg gcatcaccaa     2220

cagtcagctc aagccagaca catttgttca gcatatcaag agacacaaca tcgttctgaa     2280

gagggaactt ggggaaggag ccttcgggaa agttttcctt gccgagtgct acaacctctg     2340

cccagagcag gataagatcc tggtggctgt gaagacgctg aaggacgcca gcgacaatgc     2400

acgcaaggac tttcatcggg aagctgagct gctgaccaac ctccagcacg agcacattgt     2460

caagttctac ggtgtctgtg tggagggcga cccactcatc atggtctttg agtacatgaa     2520

gcacggggac ctcaacaagt tccttagggc acacgggccc gacgcagtgc tgatggcaga     2580

gggtaacccg cccacagagc tgacgcagtc gcagatgctg cacatcgctc agcaaatcgc     2640

agcaggtatg gtctacctgg cgtcccaaca ctttgtgcac cgtgacctgg ccacccggaa     2700

ctgcctggtg ggagagaacc tgctggtgaa aattggggac tttgggatgt cccgagatgt     2760

gtacagcacc gactactatc gggtcggtgg ccacacaatg ttgcccatcc gatggatgcc     2820

tccagagagc atcatgtaca ggaaattcac caccgagagc gacgtctgga gcctgggcgt     2880

tgtgttgtgg gagatcttca cctacggcaa gcagccctgg tatcagctat cgaacaatga     2940

ggtgatagag tgcatcaccc agggaagagt ccttcagcgg cctcgaacgt gtccccagga     3000

ggtgtatgag ctcatgcttg gatgctggca gcgggaacca cacacccgga agaacatcaa     3060

gagcatccac accctccttc agaacttggc caaggcatct cccgtctacc tggatatcct     3120

aggctagggt cctccttctg cccagaccgt ccttcccaag gccctcctca gactggccta     3180

cacgacgaac ctcttgactg ccgctgacgt catgaccttg ctgtccttcg ctctgacagt     3240

gttgacagga ccaggagcgg ctctttgggg gaggcagtgt gtgcttctcc atccacagac     3300

agtattaact cgcttctggc attgtctctt tctctccctt gggtttgttt ctttcttttg     3360

ccccttcccc ttttatcatt atttattcat ttatttattt tctggtcttc accgcttcac     3420

ggccctcagt ctctccttga ccaatctggc ttctgcattc ctattaactg tacatagaca     3480

aaggccttaa caaacctaat ttgttatatc agcagacact ccagtttgcc caccacaact     3540

aacaatgcct tgttgtattc ctgcctttga cgtggatgaa aaaaagggaa aaaaaaatca     3600

aacatctgac ttaagctgtc acttccgatg tacagacgtg gggcgtttct atggattcac     3660

ttctatttat tatttattaa tttatttatt tatcactctt cttattgttt tctggtggtt     3720

ttaacctatg tgtgagaagg aaaagttgtg tacaatctgg gaaaacttta tcagtgggaa     3780

atgaaaacga gagcgagcaa gcgagcaaga gagggagaga gagagagaag cgttaccata     3840

aaccacggca tgagcgagac agagacaagc catgggatca gtcgggagtc cgttgtgctt     3900

aggaaaaccc agcagccatt agctggggga gcatgttcgg ctctgtcccc caagcacctt     3960

tctgaggagg acacaggatg ttgaactctg cttcacgggc agagcttcta atgacagata     4020

ctggcttgca ctggaaagac agttcccacg ggacctggac ggacaacaca tcctacattc     4080

agacattgtg gtcgggcacg gtgacagagt tgatccgttt ctcaagtgtt atctaccaag     4140

cttttgtgaa gttccatcga aggaggtaga ttcttgctca gatataattt caggaaaacc     4200

cgagtccttg acaaagacag gagacgctct caatttggag gcaagtttct cttaccttga     4260

actttttcag acagcaactc cgcccagccc ccatcttcca ctctcacctg tcttgtaact     4320

gtgcaaacaa aagtgtgcat ggtctttgtc aattgatacc tatgtgcacg tgtgcagaaa     4380

ctgttgttcc agctggggtg tctgattagg agggcagatc cataaaaggt ctaacctagg     4440

caacttcggg aaaggagacc agatcagtag ctggaggcac tctccagtag gcggtgaggg     4500

gtttactgag taggcatgct gaagcccgga tattcaccca tctcaaaccc cccgggctgc     4560

aggacaggca caggccatcc ctgaggagaa ggggagccct tttgggatac cacctgaggt     4620

tatgttcagt gtgctctggt caagtccctt gctcggggct ctgtttgggg agagtggttt     4680

cattccaagg tactcattat tagtatgctg ttttgttaac tatactccat taaaaagtta     4740

aaaaaaaaaa gaattaagcc ttgacactgt atggctgaca ggaggctgtg cccagactga     4800

gcctggagat ttgcgcccgc acatggtcat tggttttccg aaaagagagg gtaaatttat     4860

atagaaattt acaggtattt gggtagtcat ttagaccgag ggagaccagt gtttccattt     4920

ctctgcgccc cctctgtgag gggaagttcg atacacttga cacctttata aacggagcca     4980

gataggaagg gagtgactta attcacctta gaacatttca tttggtgttt atttctgaag     5040

gtgcaagagc tctgtgtagg tttcatttgt gcccgagcat ttctggagca ctgtgttttc     5100

tagcagaaac tccgagagcc agttctcaca atgaaacttt aaaacctgtg taaattgaca     5160

gagagcagaa ggcgatccaa gaggcccact caagtgagtg gtggcacgag gcacatgcgg     5220

tggccctttc tgttgtgctg gcccatgaga gatgggagct attttgtcct cttcgtccat     5280

taaaacaaac ccctccagaa tacctatagt aatataatga aagccatatc tctgtgatct     5340

ataccgtcag gtatagatca ttaaaggacc catggtactg tcaggcactg tggaaccgtg     5400

aggcagcgga aaggcaaggg cacatttgta catgttcctc tagcttccgc cagccgtgac     5460

ctatgaactc acataggccg gttgctccta gtctgacggg ctgccctggg aggaaaagct     5520

gcaagatgct cagcagagag caaaggagag gatagtcttg gaaaaggcca aggttgggga     5580

tgccatacag gattacacca aagggctgta ctgagaatgt gggagcattc cattccaggt     5640

ttgtattttc ctcagcaaga aaaaagagca gatagaaggg cagaggagga tagagaggaa     5700

gagaaaggag agggagaaga gagcagagaa gagagagaga gagagagaga gagagaatct     5760

ttatactttt tggcaagtcc tcgaaggtct caaaatgaaa gtgtctatgc aagtgcaaat     5820

ttttacagtt atttatacta attattatta ttgttattaa ttattattat tactagtctg     5880

ttgtctcaag aatatgtgca gatttcagag cattaaagag tatttggttt cttttaaagt     5940

agttgggtga gccaaggaca ccttaaaata attgtcactg ttcatctgct atcgcctttc     6000

tcatggtatt ttaagtttta gaaaagaaac attcttgttc taaaacatat ccctctccat     6060

agatgacaaa aaaaaatggt gttagcaaac cgaaacctcc cccgattcct gtctgacatc     6120

cgatccattt ctcaactgct tgatgatttc cgagcgcttt ttgcatatgt tgtcaaaata     6180

ttcatattat tttggtgagg gaatggagac tcagaaactc agaggacaaa cataagcttc     6240

accgaagtct gtctgccaga tacaaactaa catacaaaca agacagccgg gaaggaaatg     6300

tgctggtagc gtgtctgtgg agcagggtgg gggttagaac agaaggagac ctgggcagtg     6360

cacgcagaag agatgttaca tcatgtgctt ctgctcctgg cttctgctga ctcccaactt     6420

tgcgctcagc ctcatttaga aaacgcttca aacactgctc ttcagggttc tgtcagaact     6480

cacacacacg tgctcacacc agccccgctt gtgacgtttt tatgtacttc tatataaata     6540

tatacataat atatgttata aacacttgat ttatacatat acaaatgcac acatgtagtg     6600

tgtttgtgtg tttatgtata aacatatagg ctcatggtaa tagaataatt ataagtaggg     6660

tgcaatatga ataatttgct taatatttgc taagtaacca aaactttcca acgtcatgtg     6720

gcagttcata tttccactct cagtgtgggt aaggatgggc tacaccacac tttcagctct     6780

gtgcagccct tggatggaag atgtgttgaa aaaaaaatca catcttccct gaaacaactg     6840

actgaaagcc atcctctaca ttgaatctgt tctctggctc tttgcaaagg agaaatgcag     6900

acaaatggtc tccttgtgtc ccagtcctgg gaaggagaag tgggttttct cttcttgcac     6960

atttgggccg tgctcacctt tcctggctct atgcccttta cactgggctc agagatgaag     7020

cagtctagac ccaagctgca gggctgtagg gaggcaaatg tcttcgaggc tgatagcaaa     7080

gcatccaaaa atctatagca agatgcgcag cttgaagtca ctcctcatcc acacggcaag     7140

caagagccag ggcatgcagt gctgtccatc tctaggactg ggcagtgggg tccccggtca     7200

agggcagtct ttccctaagc ctctcctttt gcaaatggca ctgccagcag tacctggcat     7260

taagtcacga aaaatttcta aaatggcagc acagacccgt gtgccctcat tgctctgccc     7320

ccacatgcct catcattaga gggctccagt tttcaaactt gactttccat ttggccctgt     7380

atcgtggtta aaggaaatct caacagaggg atggccaatt gacctaaatc cccagatgtc     7440

caagtttgca gtgaaagcca gttcttccca aatgtataac tggaatgtag ggactcaggt     7500

tgtgatactt catacaggaa tctcagatgt tattgtaaag aactgggttg ggagggattc     7560

atcactaagc caacaataat gcaggagggc gtggctgatc gttaagccaa tagtagtgca     7620

ggagggcgtg gctgctgtga gggctggaat ccatctctgc tgctaaagtt cagggttctc     7680

aactcttttc agctgttgca gcccttcact tctttccctt cggcgttatt tatttgtgta     7740

tttatttatt tatttattta tttatctatc tatctatcaa cttttggtcc attcatcacc     7800

aacataaagc aaaaacaatt ttttacatat atgtaaatgt gttgcaagtg aaacactgtg     7860

aatctcacaa ccacctccta gcaactatgc tgccatcttg acgtgcgtct caggagtcga     7920

gacgggaaaa gacgaggacg tcattttgca gcctacgcat tctgggccag gtccgtgttc     7980

gttttatttc tttagtctgt gagttaagaa aacaatccga gtggagggtg acggatgttc     8040

ggcaagttcg gtgaagcagc acgagctctt tgcagctata ggttcgagca agaagaaaaa     8100

ccatgggaga tggagaaggg aaatttgatg gaggggtggg gtggggtggg ggctctgtct     8160

tacagctcgt gtagcttact gttgcttaaa aatgtataca acagctggaa atgttttcaa     8220

cacaaggtat ttgaaataaa tgtgaatctt aaatatgtac tcccttaagg aatgaacata     8280

ttatggtgaa atattgctcc cccgcgtccc ctacaaatct gcctagagat gtggatacct     8340

acatttgctt aagcatcaga ccagtgtttg tatatacccg ggccatacac actcatctcg     8400

acgtctctct gcggatgtat ttccccttca ctggtgacct ggtatttaga actccgtctt     8460

ttcagttggt ttatttccct ttaatgtgat gtctctgtgc cgattattac cggttcttac     8520

ttgtttttgc aatccgtttt gaggtccagt gttttactga gactcattgc atcttggctg     8580

atttcaaagt gacacccgaa tacagtgttt aaaaaaaaag tttgtttgta aatcatgtga     8640

ccagcttctc tcaccctgac atggaatgtc tcttgtacta cagtgtattt aataataaaa     8700

gaaaaaaatg atgtcttaca ataaataaca tcttccacaa gagg                      8744


<210>  7
<211>  4750
<212>  DNA
<213>  Rattus norvegicus

<400>  7
tgtgcgtgcg tgcgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg       60

tgagcgtgtg tgtttttgga tttcatacta attttctgga gtttctgccc ctgctctgcg      120

tcagccctca cgtcacttcg ccagcagtag cagaggcggc ggcggccgcc ggttagagcc      180

cagtcgctgc ttcagctgct gttgctgctt ctgcggcgct ctgctccctg cgctggctac      240

gggaggccgg gggagccgcg ccgacagtcc tctgtggcca gggccggcac tgtcctgcta      300

ccgcagttgc tccccagccc tgaggtgcgc accgatatcg atatccgtgc cggtttagcg      360

gttctgcgac ccaaagagtc cagggagagc caccgagtgg cgcctggcgt ataggaccat      420

gcagccgcct tgtggcttgg agcagcggcc cgtgatgttc cagccactgt gaaccatttg      480

gtcagcgcca acctgctcag ccccagcacc gacaggctca gcctctggta cgctcctctc      540

ggcgggaggc catcagcacc aagcagcaag agggctcagg gaaggcctcc cccctccggc      600

gggggacgcc tggctcagcg tagggacacg cactctgact gactggcact ggcagctcgg      660

gatgtcgccc tggccgaggt ggcatggacc cgccatggcg cggctctggg gcttatgctt      720

gctggtcttg ggcttctgga gggcttctct tgcctgcccc atgtcctgca aatgcagcac      780

cactaggatt tggtgtaccg agccttctcc tggcatcgtg gcatttccga ggttggaacc      840

taacagcatt gacccagaga acatcaccga aattctcatt gcaaaccaga aaaggttaga      900

aatcatcaat gaagatgatg tcgaagctta cgtggggctg aaaaacctta caattgtgga      960

ttccggctta aagtttgtgg cttacaaggc gtttctgaag aacggcaacc tgcggcacat     1020

caatttcact cgaaacaagc tgacgagttt gtccaggaga catttccgcc accttgactt     1080

gtctgacctg atcctgacgg gtaatccgtt cacgtgttcc tgtgacatca tgtggctcaa     1140

gactctccag gagacgaaat ccagccccga cactcaggat ttgtattgcc tcaatgagag     1200

cagcaagaat acccctctgg cgaacctgca gattcccaat tgtggtctgc cgtctgcacg     1260

tctggccgct cctaacctca cggtggagga agggaagtct gtgaccattt cctgcagcgt     1320

cgggggtgac ccgctcccca ccttgtactg ggacgttggg aatttggttt ccaaacacat     1380

gaatgaaaca agccacacac agggctcctt aaggataaca aacatttcat cggatgacag     1440

tgggaaacaa atctcttgtg tggcagaaaa cctcgttgga gaagatcaag actctgtgaa     1500

cctcactgtg cattttgcac caaccatcac atttctcgaa tctccaacct cagaccacca     1560

ctggtgcatc ccattcactg tgagaggcaa ccccaagcca gcacttcagt ggttctacaa     1620

cggagccata ctgaatgaat ccaagtacat ctgtaccaaa atacacgtca ccaatcacac     1680

ggagtaccac ggctgcctcc agctggataa ccccactcat atgaataatg gagactacac     1740

cctaatggcc aagaatgaat atgggaagga cgagagacag atttctgctc acttcatggg     1800

ccggcctgga gttgactatg agacaaaccc aaattaccct gaagtcctct atgaagactg     1860

gaccacgcca actgacatcg gggatactac aaacaaaagt aatgagatcc cctccacgga     1920

tgttgctgac caaaccaatc gggagcatct ctcggtctat gccgtggtgg tgattgcctc     1980

tgtggtagga ttctgcctgc tggtgatgct gcttctgctc aagttggcga gacattccaa     2040

gtttggcatg aaaggcccag cttccgtcat cagcaacgac gatgactctg ccagccctct     2100

ccaccacatc tccaacggga gcaacactcc gtcttcttcg gagggcgggc ccgatgctgt     2160

catcattggg atgaccaaga tccctgtcat tgaaaacccc cagtacttcg gtatcaccaa     2220

cagccagctc aagccggaca catttgttca gcacatcaag agacacaaca tcgttctgaa     2280

gagggagctt ggagaaggag cctttgggaa agttttccta gcggagtgct ataacctctg     2340

ccccgagcag gataagatcc tggtggccgt gaagacgctg aaggacgcca gcgacaatgc     2400

tcgcaaggac tttcatcgcg aagccgagct gctgaccaac ctccagcacg agcacattgt     2460

caagttctac ggtgtctgtg tggagggcga cccactcatc atggtctttg agtacatgaa     2520

gcacggggac ctcaacaagt tccttagggc acacgggcca gatgcagtgc tgatggcaga     2580

gggtaacccg cccaccgagc tgacgcagtc gcagatgctg cacatcgctc agcaaatcgc     2640

agcaggcatg gtctacctgg catcccaaca cttcgtgcac cgagacctgg ccacccggaa     2700

ctgcttggta ggagagaacc tgctggtgaa aattggggac ttcgggatgt cccgggatgt     2760

atacagcacc gactactacc gggttggtgg ccacacaatg ttgcccatcc gatggatgcc     2820

tccagagagc atcatgtaca ggaaattcac caccgagagt gacgtctgga gcctgggagt     2880

tgtgttgtgg gagatcttca cctacggcaa gcagccctgg tatcagctat caaacaacga     2940

ggtgatagaa tgcatcaccc agggcagagt ccttcagcgg cctcgcacgt gtccccagga     3000

ggtgtacgag ctgatgctgg gatgctggca gcgggaacca cacacaagga agaacatcaa     3060

gaacatccac acactccttc agaacttggc gaaggcgtcg cccgtctacc tggacatcct     3120

aggctagact ccctcttctc ccagacggcc cttcccaagg cacccctcag acctcttaac     3180

tgccgctgat gtcaccacct tgctgtcctt cgctctgaca gtgttaacaa gacaaggagc     3240

ggctctccgg ggtgaggcag tgcgcacttc cccatccaca gacagtatcg actcgcttct     3300

ggctttgtcg ctttctctcc ctttggtttg tttctttctt ttgcccattc tccatttatt     3360

tatttattta tttatttatt tatttattta tttatctatc tatctatcta tctatctatc     3420

tatttattta tttattggtc ttcactgctt catggtcctc ggcctctctc cttgaccgat     3480

ctggcttctg tactcctatt cactgtacat agacaaaggc cttaacaaac ctgatttgtt     3540

atatcagcag acactccagt ttgcccacca caactaacaa tgccttgttg tattcctgcc     3600

tttgatgtgg atgaaaaaaa gggaaaaaaa aataatcaaa catctgactt aaaccgtcac     3660

ttccgatgta cagacacggg gcgtttctat ggattcactt ctatctatct atttatttat     3720

ttatctattt atttatttct cttctttgtt gttttccggt ggttttagcc tgtgtatgag     3780

aagggaaagt catgtacagt ctgggaaaac tttatctgtg ggaaatggaa accagaaagg     3840

gaaagaagct ttaccataaa gcacagcagg agtgagacac agaaaagcca ttggatcagc     3900

cagagtccgt cctgcatagg aaaacccagc agccatcagg ctggaggatc atgttcggca     3960

ctgacccccg aggacctttc tgaggaggac acagaatgtt aaactctgca tcatggacac     4020

agtttccgat cacagatact ggccttcaat ggaaaaaaaa aaaaacccag atagttcttg     4080

tgagacctgg acagcacgtc caacatccag acattgtggt cgggcacagt gacagagttg     4140

atgcatttct cacgggttat tctacagagc ttttgtcaag tccaatggaa ggaggtagat     4200

tcttgttcag atatgatttc gggaaaaacc gagtccttga caaagacagg agacaccctc     4260

agttgggagg caagtttctc ttaccttgga ctttctcaca cagcaattct cacccccacc     4320

ccctccactc tcacctgtct tgtaactgtg caaacaaaag tgtgcatggt ctttgtcagt     4380

tgataccttt gtgcacctct gtgcagaaac tgctgtctgt cccggctgtg gtacccgatc     4440

agtggggtag atccacgaaa ggtctcattt taggccgctt tgggaaggta accagatcgg     4500

tagctggaag cactctccag taggtggcga agggtgagtg ggtctgctga agcctgcata     4560

tcttcaccca cctcaaaccc accgggctgc acaggggaca ggcacaggcc acccctgagg     4620

gacagggaag ctctcttggg ataccacctg agtttacatt cagtgtgctc aggtcaagtc     4680

tctcgctcgg ggctctgttt cggggagaat ggtttcattc caacgcactc attatcagga     4740

ttctgttttc                                                            4750


<210>  8
<211>  4057
<212>  DNA
<213>  Homo sapiens

<400>  8
gggagcagga gcctcgctgg ctgcttcgct cgcgctctac gcgctcagtc cccggcggta       60

gcaggagcct ggacccaggc gccggcggcg ggcgtgaggc gccggagccc ggcctcgagg      120

tgcataccgg acccccattc gcatctaaca aggaatctgc gccccagaga gtcccggacg      180

ccgccggtcg gtgcccggcg cgccgggcca tgcagcgacg gccgccgcgg agctccgagc      240

agcggtagcg cccccctgta aagcggttcg ctatgccggg accactgtga accctgccgc      300

ctgccggaac actcttcgct ccggaccagc tcagcctctg ataagctgga ctcggcacgc      360

ccgcaacaag caccgaggag ttaagagagc cgcaagcgca gggaaggcct ccccgcacgg      420

gtgggggaaa gcggccggtg cagcgcgggg acaggcactc gggctggcac tggctgctag      480

ggatgtcgtc ctggataagg tggcatggac ccgccatggc gcggctctgg ggcttctgct      540

ggctggttgt gggcttctgg agggccgctt tcgcctgtcc cacgtcctgc aaatgcagtg      600

cctctcggat ctggtgcagc gacccttctc ctggcatcgt ggcatttccg agattggagc      660

ctaacagtgt agatcctgag aacatcaccg aaattttcat cgcaaaccag aaaaggttag      720

aaatcatcaa cgaagatgat gttgaagctt atgtgggact gagaaatctg acaattgtgg      780

attctggatt aaaatttgtg gctcataaag catttctgaa aaacagcaac ctgcagcaca      840

tcaattttac ccgaaacaaa ctgacgagtt tgtctaggaa acatttccgt caccttgact      900

tgtctgaact gatcctggtg ggcaatccat ttacatgctc ctgtgacatt atgtggatca      960

agactctcca agaggctaaa tccagtccag acactcagga tttgtactgc ctgaatgaaa     1020

gcagcaagaa tattcccctg gcaaacctgc agatacccaa ttgtggtttg ccatctgcaa     1080

atctggccgc acctaacctc actgtggagg aaggaaagtc tatcacatta tcctgtagtg     1140

tggcaggtga tccggttcct aatatgtatt gggatgttgg taacctggtt tccaaacata     1200

tgaatgaaac aagccacaca cagggctcct taaggataac taacatttca tccgatgaca     1260

gtgggaagca gatctcttgt gtggcggaaa atcttgtagg agaagatcaa gattctgtca     1320

acctcactgt gcattttgca ccaactatca catttctcga atctccaacc tcagaccacc     1380

actggtgcat tccattcact gtgaaaggca accccaaacc agcgcttcag tggttctata     1440

acggggcaat attgaatgag tccaaataca tctgtactaa aatacatgtt accaatcaca     1500

cggagtacca cggctgcctc cagctggata atcccactca catgaacaat ggggactaca     1560

ctctaatagc caagaatgag tatgggaagg atgagaaaca gatttctgct cacttcatgg     1620

gctggcctgg aattgacgat ggtgcaaacc caaattatcc tgatgtaatt tatgaagatt     1680

atggaactgc agcgaatgac atcggggaca ccacgaacag aagtaatgaa atcccttcca     1740

cagacgtcac tgataaaacc ggtcgggaac atctctcggt ctatgctgtg gtggtgattg     1800

cgtctgtggt gggattttgc cttttggtaa tgctgtttct gcttaagttg gcaagacact     1860

ccaagtttgg catgaaagat ttctcatggt ttggatttgg gaaagtaaaa tcaagacaag     1920

gtgttggccc agcctccgtt atcagcaatg atgatgactc tgccagccca ctccatcaca     1980

tctccaatgg gagtaacact ccatcttctt cggaaggtgg cccagatgct gtcattattg     2040

gaatgaccaa gatccctgtc attgaaaatc cccagtactt tggcatcacc aacagtcagc     2100

tcaagccaga cacatttgtt cagcacatca agcgacataa cattgttctg aaaagggagc     2160

taggcgaagg agcctttgga aaagtgttcc tagctgaatg ctataacctc tgtcctgagc     2220

aggacaagat cttggtggca gtgaagaccc tgaaggatgc cagtgacaat gcacgcaagg     2280

acttccaccg tgaggccgag ctcctgacca acctccagca tgagcacatc gtcaagttct     2340

atggcgtctg cgtggagggc gaccccctca tcatggtctt tgagtacatg aagcatgggg     2400

acctcaacaa gttcctcagg gcacacggcc ctgatgccgt gctgatggct gagggcaacc     2460

cgcccacgga actgacgcag tcgcagatgc tgcatatagc ccagcagatc gccgcgggca     2520

tggtctacct ggcgtcccag cacttcgtgc accgcgattt ggccaccagg aactgcctgg     2580

tcggggagaa cttgctggtg aaaatcgggg actttgggat gtcccgggac gtgtacagca     2640

ctgactacta cagggtcggt ggccacacaa tgctgcccat tcgctggatg cctccagaga     2700

gcatcatgta caggaaattc acgacggaaa gcgacgtctg gagcctgggg gtcgtgttgt     2760

gggagatttt cacctatggc aaacagccct ggtaccagct gtcaaacaat gaggtgatag     2820

agtgtatcac tcagggccga gtcctgcagc gaccccgcac gtgcccccag gaggtgtatg     2880

agctgatgct ggggtgctgg cagcgagagc cccacatgag gaagaacatc aagggcatcc     2940

ataccctcct tcagaacttg gccaaggcat ctccggtcta cctggacatt ctaggctagg     3000

gcccttttcc ccagaccgat ccttcccaac gtactcctca gacgggctga gaggatgaac     3060

atcttttaac tgccgctgga ggccaccaag ctgctctcct tcactctgac agtattaaca     3120

tcaaagactc cgagaagctc tcgagggaag cagtgtgtac ttcttcatcc atagacacag     3180

tattgacttc tttttggcat tatctctttc tctctttcca tctcccttgg ttgttccttt     3240

ttcttttttt aaattttctt tttcttcttt tttttcgtct tccctgcttc acgattctta     3300

ccctttcttt tgaatcaatc tggcttctgc attactatta actctgcata gacaaaggcc     3360

ttaacaaacg taatttgtta tatcagcaga cactccagtt tgcccaccac aactaacaat     3420

gccttgttgt attcctgcct ttgatgtgga tgaaaaaaag ggaaaacaaa tatttcactt     3480

aaactttgtc acttctgctg tacagatatc gagagtttct atggattcac ttctatttat     3540

ttattattat tactgttctt attgtttttg gatggcttaa gcctgtgtat aaaaaagaaa     3600

acttgtgttc aatctgtgaa gcctttatct atgggagatt aaaaccagag agaaagaaga     3660

tttattatga accgcaatat gggaggaaca aagacaacca ctgggatcag ctggtgtcag     3720

tccctactta ggaaatactc agcaactgtt agctgggaag aatgtattcg gcaccttccc     3780

ctgaggacct ttctgaggag taaaaagact actggcctct gtgccatgga tgattctttt     3840

cccatcacca gaaatgatag cgtgcagtag agagcaaaga tggcttccgt gagacacaag     3900

atggcgcata gtgtgctcgg acacagtttt gtcttcgtag gttgtgatga tagcactggt     3960

ttgtttctca agcgctatcc acagaacctt tgtcaacttc agttgaaaag aggtggattc     4020

atgtccagag ctcatttcgg ggtcaggtgg gaaagcc                              4057


<210>  9
<211>  2466
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (94)..(1287)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (1288)..(1359)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (1360)..(2463)
<223>  Cytoplasmic Domain

<400>  9
atgtcgccct ggctgaagtg gcatggaccc gccatggcgc ggctctgggg cttatgcctg       60

ctggtcttgg gcttctggag ggcctctctc gcctgcccga cgtcctgcaa atgcagttcc      120

gctaggattt ggtgtactga gccttctcca ggcatcgtgg cattcccgag gttggaacct      180

aacagcgttg acccggagaa catcacggaa attctcattg caaaccagaa aaggctagaa      240

atcatcaatg aagatgacgt tgaagcttac gtggggctga gaaaccttac aattgtggat      300

tccggcttaa agtttgtggc ttacaaagcg tttctgaaaa acagcaacct gcggcacata      360

aatttcacac gaaacaagct gacgagtttg tccaggagac atttccgcca ccttgacttg      420

tctgacctga tcctgacggg taatccgttc acgtgctcct gcgacatcat gtggctcaag      480

actctccagg agactaaatc cagccccgac actcaggatt tgtactgcct caatgagagc      540

agcaagaaca tgcccctggc gaacctgcag atacccaatt gtggtctgcc atctgcacgt      600

ctggctgctc ctaacctcac cgtggaggaa ggaaagtctg tgaccctttc ctgcagtgtg      660

gggggtgacc cactccccac cttgtactgg gacgttggga atttggtttc caagcacatg      720

aatgaaacaa gccacacaca gggctcctta aggataacga acatttcatc tgatgacagt      780

ggaaagcaaa tctcttgtgt ggcagaaaac cttgtaggag aagatcaaga ttctgtgaac      840

ctcactgtgc attttgcgcc aactatcacg tttctcgagt ctccaacctc agatcaccac      900

tggtgcattc cattcactgt gagaggcaac cccaagcctg cgcttcagtg gttctacaat      960

ggggccatac tgaatgagtc caagtacatc tgtactaaga tccacgtcac caatcacacg     1020

gagtaccatg gctgcctcca gctggataac cccactcata tgaataacgg agactacacc     1080

ctgatggcca agaacgagta tgggaaggat gagagacaga tctccgctca cttcatgggc     1140

cggcctggag tcgactacga gacaaaccca aattaccctg aagtcctcta tgaagactgg     1200

accacgccaa ctgacattgg ggatactacg aacaaaagta atgaaatccc ctccacggat     1260

gttgctgacc aaagcaatcg ggagcatctc tcggtctatg ccgtggtggt gattgcatct     1320

gtggtgggat tctgcctgct ggtgatgttg ctcctgctca agttggcgag acattccaag     1380

tttggcatga aaggcccagc ttcggtcatc agcaacgacg atgactctgc cagccccctc     1440

caccacatct ccaatgggag taacactcca tcttcttcgg agggcggtcc cgacgctgtc     1500

attattggaa tgaccaagat tcctgttatt gaaaaccccc agtactttgg catcaccaac     1560

agtcagctca agccagacac atttgttcag catatcaaga gacacaacat cgttctgaag     1620

agggaacttg gggaaggagc cttcgggaaa gttttccttg ccgagtgcta caacctctgc     1680

ccagagcagg ataagatcct ggtggctgtg aagacgctga aggacgccag cgacaatgca     1740

cgcaaggact ttcatcggga agctgagctg ctgaccaacc tccagcacga gcacattgtc     1800

aagttctacg gtgtctgtgt ggagggcgac ccactcatca tggtctttga gtacatgaag     1860

cacggggacc tcaacaagtt ccttagggca cacgggcccg acgcagtgct gatggcagag     1920

ggtaacccgc ccacagagct gacgcagtcg cagatgctgc acatcgctca gcaaatcgca     1980

gcaggtatgg tctacctggc gtcccaacac tttgtgcacc gtgacctggc cacccggaac     2040

tgcctggtgg gagagaacct gctggtgaaa attggggact ttgggatgtc ccgagatgtg     2100

tacagcaccg actactatcg ggtcggtggc cacacaatgt tgcccatccg atggatgcct     2160

ccagagagca tcatgtacag gaaattcacc accgagagcg acgtctggag cctgggcgtt     2220

gtgttgtggg agatcttcac ctacggcaag cagccctggt atcagctatc gaacaatgag     2280

gtgatagagt gcatcaccca gggaagagtc cttcagcggc ctcgaacgtg tccccaggag     2340

gtgtatgagc tcatgcttgg atgctggcag cgggaaccac acacccggaa gaacatcaag     2400

agcatccaca ccctccttca gaacttggcc aaggcatctc ccgtctacct ggatatccta     2460

ggctag                                                                2466


<210>  10
<211>  2466
<212>  DNA
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (94)..(1287)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (1288)..(1359)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (1360)..(2463)
<223>  Cytoplasmic Domain

<400>  10
atgtcgccct ggccgaggtg gcatggaccc gccatggcgc ggctctgggg cttatgcttg       60

ctggtcttgg gcttctggag ggcttctctt gcctgcccca tgtcctgcaa atgcagcacc      120

actaggattt ggtgtaccga gccttctcct ggcatcgtgg catttccgag gttggaacct      180

aacagcattg acccagagaa catcaccgaa attctcattg caaaccagaa aaggttagaa      240

atcatcaatg aagatgatgt cgaagcttac gtggggctga aaaaccttac aattgtggat      300

tccggcttaa agtttgtggc ttacaaggcg tttctgaaga acggcaacct gcggcacatc      360

aatttcactc gaaacaagct gacgagtttg tccaggagac atttccgcca ccttgacttg      420

tctgacctga tcctgacggg taatccgttc acgtgttcct gtgacatcat gtggctcaag      480

actctccagg agacgaaatc cagccccgac actcaggatt tgtattgcct caatgagagc      540

agcaagaata cccctctggc gaacctgcag attcccaatt gtggtctgcc gtctgcacgt      600

ctggccgctc ctaacctcac ggtggaggaa gggaagtctg tgaccatttc ctgcagcgtc      660

gggggtgacc cgctccccac cttgtactgg gacgttggga atttggtttc caaacacatg      720

aatgaaacaa gccacacaca gggctcctta aggataacaa acatttcatc ggatgacagt      780

gggaaacaaa tctcttgtgt ggcagaaaac ctcgttggag aagatcaaga ctctgtgaac      840

ctcactgtgc attttgcacc aaccatcaca tttctcgaat ctccaacctc agaccaccac      900

tggtgcatcc cattcactgt gagaggcaac cccaagccag cacttcagtg gttctacaac      960

ggagccatac tgaatgaatc caagtacatc tgtaccaaaa tacacgtcac caatcacacg     1020

gagtaccacg gctgcctcca gctggataac cccactcata tgaataatgg agactacacc     1080

ctaatggcca agaatgaata tgggaaggac gagagacaga tttctgctca cttcatgggc     1140

cggcctggag ttgactatga gacaaaccca aattaccctg aagtcctcta tgaagactgg     1200

accacgccaa ctgacatcgg ggatactaca aacaaaagta atgagatccc ctccacggat     1260

gttgctgacc aaaccaatcg ggagcatctc tcggtctatg ccgtggtggt gattgcctct     1320

gtggtaggat tctgcctgct ggtgatgctg cttctgctca agttggcgag acattccaag     1380

tttggcatga aaggcccagc ttccgtcatc agcaacgacg atgactctgc cagccctctc     1440

caccacatct ccaacgggag caacactccg tcttcttcgg agggcgggcc cgatgctgtc     1500

atcattggga tgaccaagat ccctgtcatt gaaaaccccc agtacttcgg tatcaccaac     1560

agccagctca agccggacac atttgttcag cacatcaaga gacacaacat cgttctgaag     1620

agggagcttg gagaaggagc ctttgggaaa gttttcctag cggagtgcta taacctctgc     1680

cccgagcagg ataagatcct ggtggccgtg aagacgctga aggacgccag cgacaatgct     1740

cgcaaggact ttcatcgcga agccgagctg ctgaccaacc tccagcacga gcacattgtc     1800

aagttctacg gtgtctgtgt ggagggcgac ccactcatca tggtctttga gtacatgaag     1860

cacggggacc tcaacaagtt ccttagggca cacgggccag atgcagtgct gatggcagag     1920

ggtaacccgc ccaccgagct gacgcagtcg cagatgctgc acatcgctca gcaaatcgca     1980

gcaggcatgg tctacctggc atcccaacac ttcgtgcacc gagacctggc cacccggaac     2040

tgcttggtag gagagaacct gctggtgaaa attggggact tcgggatgtc ccgggatgta     2100

tacagcaccg actactaccg ggttggtggc cacacaatgt tgcccatccg atggatgcct     2160

ccagagagca tcatgtacag gaaattcacc accgagagtg acgtctggag cctgggagtt     2220

gtgttgtggg agatcttcac ctacggcaag cagccctggt atcagctatc aaacaacgag     2280

gtgatagaat gcatcaccca gggcagagtc cttcagcggc ctcgcacgtg tccccaggag     2340

gtgtacgagc tgatgctggg atgctggcag cgggaaccac acacaaggaa gaacatcaag     2400

aacatccaca cactccttca gaacttggcg aaggcgtcgc ccgtctacct ggacatccta     2460

ggctag                                                                2466


<210>  11
<211>  2517
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (94)..(1290)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (1291)..(1362)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (1363)..(2514)
<223>  Cytoplasmic Domain

<400>  11
atgtcgtcct ggataaggtg gcatggaccc gccatggcgc ggctctgggg cttctgctgg       60

ctggttgtgg gcttctggag ggccgctttc gcctgtccca cgtcctgcaa atgcagtgcc      120

tctcggatct ggtgcagcga cccttctcct ggcatcgtgg catttccgag attggagcct      180

aacagtgtag atcctgagaa catcaccgaa attttcatcg caaaccagaa aaggttagaa      240

atcatcaacg aagatgatgt tgaagcttat gtgggactga gaaatctgac aattgtggat      300

tctggattaa aatttgtggc tcataaagca tttctgaaaa acagcaacct gcagcacatc      360

aattttaccc gaaacaaact gacgagtttg tctaggaaac atttccgtca ccttgacttg      420

tctgaactga tcctggtggg caatccattt acatgctcct gtgacattat gtggatcaag      480

actctccaag aggctaaatc cagtccagac actcaggatt tgtactgcct gaatgaaagc      540

agcaagaata ttcccctggc aaacctgcag atacccaatt gtggtttgcc atctgcaaat      600

ctggccgcac ctaacctcac tgtggaggaa ggaaagtcta tcacattatc ctgtagtgtg      660

gcaggtgatc cggttcctaa tatgtattgg gatgttggta acctggtttc caaacatatg      720

aatgaaacaa gccacacaca gggctcctta aggataacta acatttcatc cgatgacagt      780

gggaagcaga tctcttgtgt ggcggaaaat cttgtaggag aagatcaaga ttctgtcaac      840

ctcactgtgc attttgcacc aactatcaca tttctcgaat ctccaacctc agaccaccac      900

tggtgcattc cattcactgt gaaaggcaac cccaaaccag cgcttcagtg gttctataac      960

ggggcaatat tgaatgagtc caaatacatc tgtactaaaa tacatgttac caatcacacg     1020

gagtaccacg gctgcctcca gctggataat cccactcaca tgaacaatgg ggactacact     1080

ctaatagcca agaatgagta tgggaaggat gagaaacaga tttctgctca cttcatgggc     1140

tggcctggaa ttgacgatgg tgcaaaccca aattatcctg atgtaattta tgaagattat     1200

ggaactgcag cgaatgacat cggggacacc acgaacagaa gtaatgaaat cccttccaca     1260

gacgtcactg ataaaaccgg tcgggaacat ctctcggtct atgctgtggt ggtgattgcg     1320

tctgtggtgg gattttgcct tttggtaatg ctgtttctgc ttaagttggc aagacactcc     1380

aagtttggca tgaaagattt ctcatggttt ggatttggga aagtaaaatc aagacaaggt     1440

gttggcccag cctccgttat cagcaatgat gatgactctg ccagcccact ccatcacatc     1500

tccaatggga gtaacactcc atcttcttcg gaaggtggcc cagatgctgt cattattgga     1560

atgaccaaga tccctgtcat tgaaaatccc cagtactttg gcatcaccaa cagtcagctc     1620

aagccagaca catttgttca gcacatcaag cgacataaca ttgttctgaa aagggagcta     1680

ggcgaaggag cctttggaaa agtgttccta gctgaatgct ataacctctg tcctgagcag     1740

gacaagatct tggtggcagt gaagaccctg aaggatgcca gtgacaatgc acgcaaggac     1800

ttccaccgtg aggccgagct cctgaccaac ctccagcatg agcacatcgt caagttctat     1860

ggcgtctgcg tggagggcga ccccctcatc atggtctttg agtacatgaa gcatggggac     1920

ctcaacaagt tcctcagggc acacggccct gatgccgtgc tgatggctga gggcaacccg     1980

cccacggaac tgacgcagtc gcagatgctg catatagccc agcagatcgc cgcgggcatg     2040

gtctacctgg cgtcccagca cttcgtgcac cgcgatttgg ccaccaggaa ctgcctggtc     2100

ggggagaact tgctggtgaa aatcggggac tttgggatgt cccgggacgt gtacagcact     2160

gactactaca gggtcggtgg ccacacaatg ctgcccattc gctggatgcc tccagagagc     2220

atcatgtaca ggaaattcac gacggaaagc gacgtctgga gcctgggggt cgtgttgtgg     2280

gagattttca cctatggcaa acagccctgg taccagctgt caaacaatga ggtgatagag     2340

tgtatcactc agggccgagt cctgcagcga ccccgcacgt gcccccagga ggtgtatgag     2400

ctgatgctgg ggtgctggca gcgagagccc cacatgagga agaacatcaa gggcatccat     2460

accctccttc agaacttggc caaggcatct ccggtctacc tggacattct aggctag        2517


<210>  12
<211>  2469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (94)..(1290)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (94)..(1296)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (1291)..(1362)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (1297)..(2466)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (1363)..(2466)
<223>  Cytoplasmic Domain

<400>  12
atgtcgccct ggctgaagtg gcatggaccc gccatggcgc ggctctgggg cttatgcctg       60

ctggtcttgg gcttctggag ggcctctctc gcctgtccca cgtcctgcaa atgcagtgcc      120

tctcggatct ggtgcagcga cccttctcct ggcatcgtgg catttccgag attggagcct      180

aacagtgtag atcctgagaa catcaccgaa attttcatcg caaaccagaa aaggttagaa      240

atcatcaacg aagatgatgt tgaagcttat gtgggactga gaaatctgac aattgtggat      300

tctggattaa aatttgtggc tcataaagca tttctgaaaa acagcaacct gcagcacatc      360

aattttaccc gaaacaaact gacgagtttg tctaggaaac atttccgtca ccttgacttg      420

tctgaactga tcctggtggg caatccattt acatgctcct gtgacattat gtggatcaag      480

actctccaag aggctaaatc cagtccagac actcaggatt tgtactgcct gaatgaaagc      540

agcaagaata ttcccctggc aaacctgcag atacccaatt gtggtttgcc atctgcaaat      600

ctggccgcac ctaacctcac tgtggaggaa ggaaagtcta tcacattatc ctgtagtgtg      660

gcaggtgatc cggttcctaa tatgtattgg gatgttggta acctggtttc caaacatatg      720

aatgaaacaa gccacacaca gggctcctta aggataacta acatttcatc cgatgacagt      780

gggaagcaga tctcttgtgt ggcggaaaat cttgtaggag aagatcaaga ttctgtcaac      840

ctcactgtgc attttgcacc aactatcaca tttctcgaat ctccaacctc agaccaccac      900

tggtgcattc cattcactgt gaaaggcaac cccaaaccag cgcttcagtg gttctataac      960

ggggcaatat tgaatgagtc caaatacatc tgtactaaaa tacatgttac caatcacacg     1020

gagtaccacg gctgcctcca gctggataat cccactcaca tgaacaatgg ggactacact     1080

ctaatagcca agaatgagta tgggaaggat gagaaacaga tttctgctca cttcatgggc     1140

tggcctggaa ttgacgatgg tgcaaaccca aattatcctg atgtaattta tgaagattat     1200

ggaactgcag cgaatgacat cggggacacc acgaacagaa gtaatgaaat cccttccaca     1260

gacgtcactg ataaaaccgg tcgggaacat ctctcggtct atgccgtggt ggtgattgca     1320

tctgtggtgg gattctgcct gctggtgatg ttgctcctgc tcaagttggc gagacattcc     1380

aagtttggca tgaaaggccc agcttcggtc atcagcaacg acgatgactc tgccagcccc     1440

ctccaccaca tctccaatgg gagtaacact ccatcttctt cggagggcgg tcccgacgct     1500

gtcattattg gaatgaccaa gattcctgtt attgaaaacc cccagtactt tggcatcacc     1560

aacagtcagc tcaagccaga cacatttgtt cagcatatca agagacacaa catcgttctg     1620

aagagggaac ttggggaagg agccttcggg aaagttttcc ttgccgagtg ctacaacctc     1680

tgcccagagc aggataagat cctggtggct gtgaagacgc tgaaggacgc cagcgacaat     1740

gcacgcaagg actttcatcg ggaagctgag ctgctgacca acctccagca cgagcacatt     1800

gtcaagttct acggtgtctg tgtggagggc gacccactca tcatggtctt tgagtacatg     1860

aagcacgggg acctcaacaa gttccttagg gcacacgggc ccgacgcagt gctgatggca     1920

gagggtaacc cgcccacaga gctgacgcag tcgcagatgc tgcacatcgc tcagcaaatc     1980

gcagcaggta tggtctacct ggcgtcccaa cactttgtgc accgtgacct ggccacccgg     2040

aactgcctgg tgggagagaa cctgctggtg aaaattgggg actttgggat gtcccgagat     2100

gtgtacagca ccgactacta tcgggtcggt ggccacacaa tgttgcccat ccgatggatg     2160

cctccagaga gcatcatgta caggaaattc accaccgaga gcgacgtctg gagcctgggc     2220

gttgtgttgt gggagatctt cacctacggc aagcagccct ggtatcagct atcgaacaat     2280

gaggtgatag agtgcatcac ccagggaaga gtccttcagc ggcctcgaac gtgtccccag     2340

gaggtgtatg agctcatgct tggatgctgg cagcgggaac cacacacccg gaagaacatc     2400

aagagcatcc acaccctcct tcagaacttg gccaaggcat ctcccgtcta cctggatatc     2460

ctaggctag                                                             2469


<210>  13
<211>  2469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Rat Sequence

<220>
<221>  misc_feature
<222>  (94)..(1290)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (94)..(1296)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (1291)..(1362)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (1297)..(2466)
<223>  Rat Sequence

<220>
<221>  misc_feature
<222>  (1363)..(2466)
<223>  Cytoplasmic Domain

<400>  13
atgtcgccct ggccgaggtg gcatggaccc gccatggcgc ggctctgggg cttatgcttg       60

ctggtcttgg gcttctggag ggcttctctt gcctgtccca cgtcctgcaa atgcagtgcc      120

tctcggatct ggtgcagcga cccttctcct ggcatcgtgg catttccgag attggagcct      180

aacagtgtag atcctgagaa catcaccgaa attttcatcg caaaccagaa aaggttagaa      240

atcatcaacg aagatgatgt tgaagcttat gtgggactga gaaatctgac aattgtggat      300

tctggattaa aatttgtggc tcataaagca tttctgaaaa acagcaacct gcagcacatc      360

aattttaccc gaaacaaact gacgagtttg tctaggaaac atttccgtca ccttgacttg      420

tctgaactga tcctggtggg caatccattt acatgctcct gtgacattat gtggatcaag      480

actctccaag aggctaaatc cagtccagac actcaggatt tgtactgcct gaatgaaagc      540

agcaagaata ttcccctggc aaacctgcag atacccaatt gtggtttgcc atctgcaaat      600

ctggccgcac ctaacctcac tgtggaggaa ggaaagtcta tcacattatc ctgtagtgtg      660

gcaggtgatc cggttcctaa tatgtattgg gatgttggta acctggtttc caaacatatg      720

aatgaaacaa gccacacaca gggctcctta aggataacta acatttcatc cgatgacagt      780

gggaagcaga tctcttgtgt ggcggaaaat cttgtaggag aagatcaaga ttctgtcaac      840

ctcactgtgc attttgcacc aactatcaca tttctcgaat ctccaacctc agaccaccac      900

tggtgcattc cattcactgt gaaaggcaac cccaaaccag cgcttcagtg gttctataac      960

ggggcaatat tgaatgagtc caaatacatc tgtactaaaa tacatgttac caatcacacg     1020

gagtaccacg gctgcctcca gctggataat cccactcaca tgaacaatgg ggactacact     1080

ctaatagcca agaatgagta tgggaaggat gagaaacaga tttctgctca cttcatgggc     1140

tggcctggaa ttgacgatgg tgcaaaccca aattatcctg atgtaattta tgaagattat     1200

ggaactgcag cgaatgacat cggggacacc acgaacagaa gtaatgaaat cccttccaca     1260

gacgtcactg ataaaaccgg tcgggaacat ctctcggtct atgccgtggt ggtgattgcc     1320

tctgtggtag gattctgcct gctggtgatg ctgcttctgc tcaagttggc gagacattcc     1380

aagtttggca tgaaaggccc agcttccgtc atcagcaacg acgatgactc tgccagccct     1440

ctccaccaca tctccaacgg gagcaacact ccgtcttctt cggagggcgg gcccgatgct     1500

gtcatcattg ggatgaccaa gatccctgtc attgaaaacc cccagtactt cggtatcacc     1560

aacagccagc tcaagccgga cacatttgtt cagcacatca agagacacaa catcgttctg     1620

aagagggagc ttggagaagg agcctttggg aaagttttcc tagcggagtg ctataacctc     1680

tgccccgagc aggataagat cctggtggcc gtgaagacgc tgaaggacgc cagcgacaat     1740

gctcgcaagg actttcatcg cgaagccgag ctgctgacca acctccagca cgagcacatt     1800

gtcaagttct acggtgtctg tgtggagggc gacccactca tcatggtctt tgagtacatg     1860

aagcacgggg acctcaacaa gttccttagg gcacacgggc cagatgcagt gctgatggca     1920

gagggtaacc cgcccaccga gctgacgcag tcgcagatgc tgcacatcgc tcagcaaatc     1980

gcagcaggca tggtctacct ggcatcccaa cacttcgtgc accgagacct ggccacccgg     2040

aactgcttgg taggagagaa cctgctggtg aaaattgggg acttcgggat gtcccgggat     2100

gtatacagca ccgactacta ccgggttggt ggccacacaa tgttgcccat ccgatggatg     2160

cctccagaga gcatcatgta caggaaattc accaccgaga gtgacgtctg gagcctggga     2220

gttgtgttgt gggagatctt cacctacggc aagcagccct ggtatcagct atcaaacaac     2280

gaggtgatag aatgcatcac ccagggcaga gtccttcagc ggcctcgcac gtgtccccag     2340

gaggtgtacg agctgatgct gggatgctgg cagcgggaac cacacacaag gaagaacatc     2400

aagaacatcc acacactcct tcagaacttg gcgaaggcgt cgcccgtcta cctggacatc     2460

ctaggctag                                                             2469


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
aggtgggtag gtcctggaag tg                                                22


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
aatgctgtcc caagagtggg                                                   20


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
gtcctgcatc ccttgtcttt g                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
atgtgggcgt tgtgcagtct c                                                 21


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
cgctgcagtg cattgaactc agca                                              24


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
ctgtggaggg acgtgaccag                                                   20


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
tccgctagga tttggtgtac tg                                                22


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
agccttctcc aggcatcgtg gcat                                              24


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
tccgggtcaa cgctgttag                                                    19


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
tcctgcgagg gttctgac                                                     18


<210>  24
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
tgggtgctca tatgccagag aaattgtca                                         29


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
cgatctgtga tggcctgctt ac                                                22


<210>  26
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
gggctcaggc aggtatatgt tg                                                22


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
acagatgctg tcccaaacat agcaaga                                           27


<210>  28
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
ccaaccctaa gccagtgaaa cag                                               23


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gtgctggaga ccaggagact                                                   20


<210>  30
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
tgccatactc agtttatacg gtgctgac                                          28


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gcctggtggc tcagtcaatg                                                   20


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gcagacactg gatgggtca                                                    19


<210>  33
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
ccattcgcga gttatgagaa gctgca                                            26


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
acagggttag ctggtgaatg ga                                                22


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
tcggagcaca ggactacag                                                    19


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
caagaggaac tgtgtccagg aaagc                                             25


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
agcgtgcctc acctaacctc ta                                                22


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
gcacagcact gtaaaggca                                                    19


<210>  39
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
acggaactcg aaggaattgg tattgttgt                                         29


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
acacagctat gggagaaaga ctg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
ccggttggcg agtgcgcatg cac                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
ccttccggtt ggcgagtgcg cat                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
ccaagggtgc gttgatggat cta                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
gaatgccaag ggtgcgttga tgg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
ctgggtgatt gggactgaga aag                                               23


<210>  46
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
cagccttgaa agtatggctt gggc                                              24


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gcactcgcca accggaag                                                     18


<210>  48
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gaccagctca cccttactta tgg                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
actgaatgcc aagggtgcgt tga                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
tcttggaaat ccgctgaaga gtt                                               23


<210>  51
<211>  31
<212>  PRT
<213>  Mus musculus

<400>  51

Met Ser Pro Trp Leu Lys Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Leu Cys Leu Leu Val Leu Gly Phe Trp Arg Ala Ser Leu Ala 
            20                  25                  30      


<210>  52
<211>  398
<212>  PRT
<213>  Mus musculus

<400>  52

Cys Pro Thr Ser Cys Lys Cys Ser Ser Ala Arg Ile Trp Cys Thr Glu 
1               5                   10                  15      


Pro Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val 
            20                  25                  30          


Asp Pro Glu Asn Ile Thr Glu Ile Leu Ile Ala Asn Gln Lys Arg Leu 
        35                  40                  45              


Glu Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn 
    50                  55                  60                  


Leu Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala Tyr Lys Ala Phe 
65                  70                  75                  80  


Leu Lys Asn Ser Asn Leu Arg His Ile Asn Phe Thr Arg Asn Lys Leu 
                85                  90                  95      


Thr Ser Leu Ser Arg Arg His Phe Arg His Leu Asp Leu Ser Asp Leu 
            100                 105                 110         


Ile Leu Thr Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Leu 
        115                 120                 125             


Lys Thr Leu Gln Glu Thr Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr 
    130                 135                 140                 


Cys Leu Asn Glu Ser Ser Lys Asn Met Pro Leu Ala Asn Leu Gln Ile 
145                 150                 155                 160 


Pro Asn Cys Gly Leu Pro Ser Ala Arg Leu Ala Ala Pro Asn Leu Thr 
                165                 170                 175     


Val Glu Glu Gly Lys Ser Val Thr Leu Ser Cys Ser Val Gly Gly Asp 
            180                 185                 190         


Pro Leu Pro Thr Leu Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His 
        195                 200                 205             


Met Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile 
    210                 215                 220                 


Ser Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu 
225                 230                 235                 240 


Val Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro 
                245                 250                 255     


Thr Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile 
            260                 265                 270         


Pro Phe Thr Val Arg Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr 
        275                 280                 285             


Asn Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His 
    290                 295                 300                 


Val Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro 
305                 310                 315                 320 


Thr His Met Asn Asn Gly Asp Tyr Thr Leu Met Ala Lys Asn Glu Tyr 
                325                 330                 335     


Gly Lys Asp Glu Arg Gln Ile Ser Ala His Phe Met Gly Arg Pro Gly 
            340                 345                 350         


Val Asp Tyr Glu Thr Asn Pro Asn Tyr Pro Glu Val Leu Tyr Glu Asp 
        355                 360                 365             


Trp Thr Thr Pro Thr Asp Ile Gly Asp Thr Thr Asn Lys Ser Asn Glu 
    370                 375                 380                 


Ile Pro Ser Thr Asp Val Ala Asp Gln Ser Asn Arg Glu His 
385                 390                 395             


<210>  53
<211>  24
<212>  PRT
<213>  Mus musculus

<400>  53

Leu Ser Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys 
1               5                   10                  15      


Leu Leu Val Met Leu Leu Leu Leu 
            20                  


<210>  54
<211>  368
<212>  PRT
<213>  Mus musculus

<400>  54

Lys Leu Ala Arg His Ser Lys Phe Gly Met Lys Gly Pro Ala Ser Val 
1               5                   10                  15      


Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro Leu His His Ile Ser Asn 
            20                  25                  30          


Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly Gly Pro Asp Ala Val Ile 
        35                  40                  45              


Ile Gly Met Thr Lys Ile Pro Val Ile Glu Asn Pro Gln Tyr Phe Gly 
    50                  55                  60                  


Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr Phe Val Gln His Ile Lys 
65                  70                  75                  80  


Arg His Asn Ile Val Leu Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly 
                85                  90                  95      


Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Cys Pro Glu Gln Asp Lys 
            100                 105                 110         


Ile Leu Val Ala Val Lys Thr Leu Lys Asp Ala Ser Asp Asn Ala Arg 
        115                 120                 125             


Lys Asp Phe His Arg Glu Ala Glu Leu Leu Thr Asn Leu Gln His Glu 
    130                 135                 140                 


His Ile Val Lys Phe Tyr Gly Val Cys Val Glu Gly Asp Pro Leu Ile 
145                 150                 155                 160 


Met Val Phe Glu Tyr Met Lys His Gly Asp Leu Asn Lys Phe Leu Arg 
                165                 170                 175     


Ala His Gly Pro Asp Ala Val Leu Met Ala Glu Gly Asn Pro Pro Thr 
            180                 185                 190         


Glu Leu Thr Gln Ser Gln Met Leu His Ile Ala Gln Gln Ile Ala Ala 
        195                 200                 205             


Gly Met Val Tyr Leu Ala Ser Gln His Phe Val His Arg Asp Leu Ala 
    210                 215                 220                 


Thr Arg Asn Cys Leu Val Gly Glu Asn Leu Leu Val Lys Ile Gly Asp 
225                 230                 235                 240 


Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Val Gly 
                245                 250                 255     


Gly His Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Met 
            260                 265                 270         


Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Leu Gly Val Val 
        275                 280                 285             


Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser 
    290                 295                 300                 


Asn Asn Glu Val Ile Glu Cys Ile Thr Gln Gly Arg Val Leu Gln Arg 
305                 310                 315                 320 


Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu Leu Met Leu Gly Cys Trp 
                325                 330                 335     


Gln Arg Glu Pro His Thr Arg Lys Asn Ile Lys Ser Ile His Thr Leu 
            340                 345                 350         


Leu Gln Asn Leu Ala Lys Ala Ser Pro Val Tyr Leu Asp Ile Leu Gly 
        355                 360                 365             


<210>  55
<211>  31
<212>  PRT
<213>  Rattus norvegicus

<400>  55

Met Ser Pro Trp Pro Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Leu Cys Leu Leu Val Leu Gly Phe Trp Arg Ala Ser Leu Ala 
            20                  25                  30      


<210>  56
<211>  398
<212>  PRT
<213>  Rattus norvegicus

<400>  56

Cys Pro Met Ser Cys Lys Cys Ser Thr Thr Arg Ile Trp Cys Thr Glu 
1               5                   10                  15      


Pro Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Ile 
            20                  25                  30          


Asp Pro Glu Asn Ile Thr Glu Ile Leu Ile Ala Asn Gln Lys Arg Leu 
        35                  40                  45              


Glu Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Lys Asn 
    50                  55                  60                  


Leu Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala Tyr Lys Ala Phe 
65                  70                  75                  80  


Leu Lys Asn Gly Asn Leu Arg His Ile Asn Phe Thr Arg Asn Lys Leu 
                85                  90                  95      


Thr Ser Leu Ser Arg Arg His Phe Arg His Leu Asp Leu Ser Asp Leu 
            100                 105                 110         


Ile Leu Thr Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Leu 
        115                 120                 125             


Lys Thr Leu Gln Glu Thr Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr 
    130                 135                 140                 


Cys Leu Asn Glu Ser Ser Lys Asn Thr Pro Leu Ala Asn Leu Gln Ile 
145                 150                 155                 160 


Pro Asn Cys Gly Leu Pro Ser Ala Arg Leu Ala Ala Pro Asn Leu Thr 
                165                 170                 175     


Val Glu Glu Gly Lys Ser Val Thr Ile Ser Cys Ser Val Gly Gly Asp 
            180                 185                 190         


Pro Leu Pro Thr Leu Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His 
        195                 200                 205             


Met Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile 
    210                 215                 220                 


Ser Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu 
225                 230                 235                 240 


Val Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro 
                245                 250                 255     


Thr Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile 
            260                 265                 270         


Pro Phe Thr Val Arg Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr 
        275                 280                 285             


Asn Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His 
    290                 295                 300                 


Val Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro 
305                 310                 315                 320 


Thr His Met Asn Asn Gly Asp Tyr Thr Leu Met Ala Lys Asn Glu Tyr 
                325                 330                 335     


Gly Lys Asp Glu Arg Gln Ile Ser Ala His Phe Met Gly Arg Pro Gly 
            340                 345                 350         


Val Asp Tyr Glu Thr Asn Pro Asn Tyr Pro Glu Val Leu Tyr Glu Asp 
        355                 360                 365             


Trp Thr Thr Pro Thr Asp Ile Gly Asp Thr Thr Asn Lys Ser Asn Glu 
    370                 375                 380                 


Ile Pro Ser Thr Asp Val Ala Asp Gln Thr Asn Arg Glu His 
385                 390                 395             


<210>  57
<211>  24
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Leu Ser Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys 
1               5                   10                  15      


Leu Leu Val Met Leu Leu Leu Leu 
            20                  


<210>  58
<211>  368
<212>  PRT
<213>  Rattus norvegicus

<400>  58

Lys Leu Ala Arg His Ser Lys Phe Gly Met Lys Gly Pro Ala Ser Val 
1               5                   10                  15      


Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro Leu His His Ile Ser Asn 
            20                  25                  30          


Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly Gly Pro Asp Ala Val Ile 
        35                  40                  45              


Ile Gly Met Thr Lys Ile Pro Val Ile Glu Asn Pro Gln Tyr Phe Gly 
    50                  55                  60                  


Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr Phe Val Gln His Ile Lys 
65                  70                  75                  80  


Arg His Asn Ile Val Leu Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly 
                85                  90                  95      


Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Cys Pro Glu Gln Asp Lys 
            100                 105                 110         


Ile Leu Val Ala Val Lys Thr Leu Lys Asp Ala Ser Asp Asn Ala Arg 
        115                 120                 125             


Lys Asp Phe His Arg Glu Ala Glu Leu Leu Thr Asn Leu Gln His Glu 
    130                 135                 140                 


His Ile Val Lys Phe Tyr Gly Val Cys Val Glu Gly Asp Pro Leu Ile 
145                 150                 155                 160 


Met Val Phe Glu Tyr Met Lys His Gly Asp Leu Asn Lys Phe Leu Arg 
                165                 170                 175     


Ala His Gly Pro Asp Ala Val Leu Met Ala Glu Gly Asn Pro Pro Thr 
            180                 185                 190         


Glu Leu Thr Gln Ser Gln Met Leu His Ile Ala Gln Gln Ile Ala Ala 
        195                 200                 205             


Gly Met Val Tyr Leu Ala Ser Gln His Phe Val His Arg Asp Leu Ala 
    210                 215                 220                 


Thr Arg Asn Cys Leu Val Gly Glu Asn Leu Leu Val Lys Ile Gly Asp 
225                 230                 235                 240 


Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Val Gly 
                245                 250                 255     


Gly His Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Met 
            260                 265                 270         


Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Leu Gly Val Val 
        275                 280                 285             


Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser 
    290                 295                 300                 


Asn Asn Glu Val Ile Glu Cys Ile Thr Gln Gly Arg Val Leu Gln Arg 
305                 310                 315                 320 


Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu Leu Met Leu Gly Cys Trp 
                325                 330                 335     


Gln Arg Glu Pro His Thr Arg Lys Asn Ile Lys Asn Ile His Thr Leu 
            340                 345                 350         


Leu Gln Asn Leu Ala Lys Ala Ser Pro Val Tyr Leu Asp Ile Leu Gly 
        355                 360                 365             


<210>  59
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala 
            20                  25                  30      


<210>  60
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  60

Cys Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp 
1               5                   10                  15      


Pro Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val 
            20                  25                  30          


Asp Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu 
        35                  40                  45              


Glu Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn 
    50                  55                  60                  


Leu Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe 
65                  70                  75                  80  


Leu Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu 
                85                  90                  95      


Thr Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu 
            100                 105                 110         


Ile Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile 
        115                 120                 125             


Lys Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr 
    130                 135                 140                 


Cys Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile 
145                 150                 155                 160 


Pro Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr 
                165                 170                 175     


Val Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp 
            180                 185                 190         


Pro Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His 
        195                 200                 205             


Met Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile 
    210                 215                 220                 


Ser Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu 
225                 230                 235                 240 


Val Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro 
                245                 250                 255     


Thr Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile 
            260                 265                 270         


Pro Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr 
        275                 280                 285             


Asn Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His 
    290                 295                 300                 


Val Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro 
305                 310                 315                 320 


Thr His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr 
                325                 330                 335     


Gly Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly 
            340                 345                 350         


Ile Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp 
        355                 360                 365             


Tyr Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn 
    370                 375                 380                 


Glu Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His 
385                 390                 395                 


<210>  61
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  61

Leu Ser Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys 
1               5                   10                  15      


Leu Leu Val Met Leu Phe Leu Leu 
            20                  


<210>  62
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  62

Lys Leu Ala Arg His Ser Lys Phe Gly Met Lys Asp Phe Ser Trp Phe 
1               5                   10                  15      


Gly Phe Gly Lys Val Lys Ser Arg Gln Gly Val Gly Pro Ala Ser Val 
            20                  25                  30          


Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro Leu His His Ile Ser Asn 
        35                  40                  45              


Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly Gly Pro Asp Ala Val Ile 
    50                  55                  60                  


Ile Gly Met Thr Lys Ile Pro Val Ile Glu Asn Pro Gln Tyr Phe Gly 
65                  70                  75                  80  


Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr Phe Val Gln His Ile Lys 
                85                  90                  95      


Arg His Asn Ile Val Leu Lys Arg Glu Leu Gly Glu Gly Ala Phe Gly 
            100                 105                 110         


Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Cys Pro Glu Gln Asp Lys 
        115                 120                 125             


Ile Leu Val Ala Val Lys Thr Leu Lys Asp Ala Ser Asp Asn Ala Arg 
    130                 135                 140                 


Lys Asp Phe His Arg Glu Ala Glu Leu Leu Thr Asn Leu Gln His Glu 
145                 150                 155                 160 


His Ile Val Lys Phe Tyr Gly Val Cys Val Glu Gly Asp Pro Leu Ile 
                165                 170                 175     


Met Val Phe Glu Tyr Met Lys His Gly Asp Leu Asn Lys Phe Leu Arg 
            180                 185                 190         


Ala His Gly Pro Asp Ala Val Leu Met Ala Glu Gly Asn Pro Pro Thr 
        195                 200                 205             


Glu Leu Thr Gln Ser Gln Met Leu His Ile Ala Gln Gln Ile Ala Ala 
    210                 215                 220                 


Gly Met Val Tyr Leu Ala Ser Gln His Phe Val His Arg Asp Leu Ala 
225                 230                 235                 240 


Thr Arg Asn Cys Leu Val Gly Glu Asn Leu Leu Val Lys Ile Gly Asp 
                245                 250                 255     


Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp Tyr Tyr Arg Val Gly 
            260                 265                 270         


Gly His Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Met 
        275                 280                 285             


Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Leu Gly Val Val 
    290                 295                 300                 


Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser 
305                 310                 315                 320 


Asn Asn Glu Val Ile Glu Cys Ile Thr Gln Gly Arg Val Leu Gln Arg 
                325                 330                 335     


Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu Leu Met Leu Gly Cys Trp 
            340                 345                 350         


Gln Arg Glu Pro His Met Arg Lys Asn Ile Lys Gly Ile His Thr Leu 
        355                 360                 365             


Leu Gln Asn Leu Ala Lys Ala Ser Pro Val Tyr Leu Asp Ile Leu Gly 
    370                 375                 380                 


<210>  63
<211>  93
<212>  DNA
<213>  Mus musculus

<400>  63
atgtcgccct ggctgaagtg gcatggaccc gccatggcgc ggctctgggg cttatgcctg       60

ctggtcttgg gcttctggag ggcctctctc gcc                                    93


<210>  64
<211>  1194
<212>  DNA
<213>  Mus musculus

<400>  64
tgcccgacgt cctgcaaatg cagttccgct aggatttggt gtactgagcc ttctccaggc       60

atcgtggcat tcccgaggtt ggaacctaac agcgttgacc cggagaacat cacggaaatt      120

ctcattgcaa accagaaaag gctagaaatc atcaatgaag atgacgttga agcttacgtg      180

gggctgagaa accttacaat tgtggattcc ggcttaaagt ttgtggctta caaagcgttt      240

ctgaaaaaca gcaacctgcg gcacataaat ttcacacgaa acaagctgac gagtttgtcc      300

aggagacatt tccgccacct tgacttgtct gacctgatcc tgacgggtaa tccgttcacg      360

tgctcctgcg acatcatgtg gctcaagact ctccaggaga ctaaatccag ccccgacact      420

caggatttgt actgcctcaa tgagagcagc aagaacatgc ccctggcgaa cctgcagata      480

cccaattgtg gtctgccatc tgcacgtctg gctgctccta acctcaccgt ggaggaagga      540

aagtctgtga ccctttcctg cagtgtgggg ggtgacccac tccccacctt gtactgggac      600

gttgggaatt tggtttccaa gcacatgaat gaaacaagcc acacacaggg ctccttaagg      660

ataacgaaca tttcatctga tgacagtgga aagcaaatct cttgtgtggc agaaaacctt      720

gtaggagaag atcaagattc tgtgaacctc actgtgcatt ttgcgccaac tatcacgttt      780

ctcgagtctc caacctcaga tcaccactgg tgcattccat tcactgtgag aggcaacccc      840

aagcctgcgc ttcagtggtt ctacaatggg gccatactga atgagtccaa gtacatctgt      900

actaagatcc acgtcaccaa tcacacggag taccatggct gcctccagct ggataacccc      960

actcatatga ataacggaga ctacaccctg atggccaaga acgagtatgg gaaggatgag     1020

agacagatct ccgctcactt catgggccgg cctggagtcg actacgagac aaacccaaat     1080

taccctgaag tcctctatga agactggacc acgccaactg acattgggga tactacgaac     1140

aaaagtaatg aaatcccctc cacggatgtt gctgaccaaa gcaatcggga gcat           1194


<210>  65
<211>  72
<212>  DNA
<213>  Mus musculus

<400>  65
ctctcggtct atgccgtggt ggtgattgca tctgtggtgg gattctgcct gctggtgatg       60

ttgctcctgc tc                                                           72


<210>  66
<211>  1104
<212>  DNA
<213>  Mus musculus

<400>  66
aagttggcga gacattccaa gtttggcatg aaaggcccag cttcggtcat cagcaacgac       60

gatgactctg ccagccccct ccaccacatc tccaatggga gtaacactcc atcttcttcg      120

gagggcggtc ccgacgctgt cattattgga atgaccaaga ttcctgttat tgaaaacccc      180

cagtactttg gcatcaccaa cagtcagctc aagccagaca catttgttca gcatatcaag      240

agacacaaca tcgttctgaa gagggaactt ggggaaggag ccttcgggaa agttttcctt      300

gccgagtgct acaacctctg cccagagcag gataagatcc tggtggctgt gaagacgctg      360

aaggacgcca gcgacaatgc acgcaaggac tttcatcggg aagctgagct gctgaccaac      420

ctccagcacg agcacattgt caagttctac ggtgtctgtg tggagggcga cccactcatc      480

atggtctttg agtacatgaa gcacggggac ctcaacaagt tccttagggc acacgggccc      540

gacgcagtgc tgatggcaga gggtaacccg cccacagagc tgacgcagtc gcagatgctg      600

cacatcgctc agcaaatcgc agcaggtatg gtctacctgg cgtcccaaca ctttgtgcac      660

cgtgacctgg ccacccggaa ctgcctggtg ggagagaacc tgctggtgaa aattggggac      720

tttgggatgt cccgagatgt gtacagcacc gactactatc gggtcggtgg ccacacaatg      780

ttgcccatcc gatggatgcc tccagagagc atcatgtaca ggaaattcac caccgagagc      840

gacgtctgga gcctgggcgt tgtgttgtgg gagatcttca cctacggcaa gcagccctgg      900

tatcagctat cgaacaatga ggtgatagag tgcatcaccc agggaagagt ccttcagcgg      960

cctcgaacgt gtccccagga ggtgtatgag ctcatgcttg gatgctggca gcgggaacca     1020

cacacccgga agaacatcaa gagcatccac accctccttc agaacttggc caaggcatct     1080

cccgtctacc tggatatcct aggc                                            1104


<210>  67
<211>  93
<212>  DNA
<213>  Rattus norvegicus

<400>  67
atgtcgccct ggccgaggtg gcatggaccc gccatggcgc ggctctgggg cttatgcttg       60

ctggtcttgg gcttctggag ggcttctctt gcc                                    93


<210>  68
<211>  1194
<212>  DNA
<213>  Rattus norvegicus

<400>  68
tgccccatgt cctgcaaatg cagcaccact aggatttggt gtaccgagcc ttctcctggc       60

atcgtggcat ttccgaggtt ggaacctaac agcattgacc cagagaacat caccgaaatt      120

ctcattgcaa accagaaaag gttagaaatc atcaatgaag atgatgtcga agcttacgtg      180

gggctgaaaa accttacaat tgtggattcc ggcttaaagt ttgtggctta caaggcgttt      240

ctgaagaacg gcaacctgcg gcacatcaat ttcactcgaa acaagctgac gagtttgtcc      300

aggagacatt tccgccacct tgacttgtct gacctgatcc tgacgggtaa tccgttcacg      360

tgttcctgtg acatcatgtg gctcaagact ctccaggaga cgaaatccag ccccgacact      420

caggatttgt attgcctcaa tgagagcagc aagaataccc ctctggcgaa cctgcagatt      480

cccaattgtg gtctgccgtc tgcacgtctg gccgctccta acctcacggt ggaggaaggg      540

aagtctgtga ccatttcctg cagcgtcggg ggtgacccgc tccccacctt gtactgggac      600

gttgggaatt tggtttccaa acacatgaat gaaacaagcc acacacaggg ctccttaagg      660

ataacaaaca tttcatcgga tgacagtggg aaacaaatct cttgtgtggc agaaaacctc      720

gttggagaag atcaagactc tgtgaacctc actgtgcatt ttgcaccaac catcacattt      780

ctcgaatctc caacctcaga ccaccactgg tgcatcccat tcactgtgag aggcaacccc      840

aagccagcac ttcagtggtt ctacaacgga gccatactga atgaatccaa gtacatctgt      900

accaaaatac acgtcaccaa tcacacggag taccacggct gcctccagct ggataacccc      960

actcatatga ataatggaga ctacacccta atggccaaga atgaatatgg gaaggacgag     1020

agacagattt ctgctcactt catgggccgg cctggagttg actatgagac aaacccaaat     1080

taccctgaag tcctctatga agactggacc acgccaactg acatcgggga tactacaaac     1140

aaaagtaatg agatcccctc cacggatgtt gctgaccaaa ccaatcggga gcat           1194


<210>  69
<211>  72
<212>  DNA
<213>  Rattus norvegicus

<400>  69
ctctcggtct atgccgtggt ggtgattgcc tctgtggtag gattctgcct gctggtgatg       60

ctgcttctgc tc                                                           72


<210>  70
<211>  1104
<212>  DNA
<213>  Rattus norvegicus

<400>  70
aagttggcga gacattccaa gtttggcatg aaaggcccag cttccgtcat cagcaacgac       60

gatgactctg ccagccctct ccaccacatc tccaacggga gcaacactcc gtcttcttcg      120

gagggcgggc ccgatgctgt catcattggg atgaccaaga tccctgtcat tgaaaacccc      180

cagtacttcg gtatcaccaa cagccagctc aagccggaca catttgttca gcacatcaag      240

agacacaaca tcgttctgaa gagggagctt ggagaaggag cctttgggaa agttttccta      300

gcggagtgct ataacctctg ccccgagcag gataagatcc tggtggccgt gaagacgctg      360

aaggacgcca gcgacaatgc tcgcaaggac tttcatcgcg aagccgagct gctgaccaac      420

ctccagcacg agcacattgt caagttctac ggtgtctgtg tggagggcga cccactcatc      480

atggtctttg agtacatgaa gcacggggac ctcaacaagt tccttagggc acacgggcca      540

gatgcagtgc tgatggcaga gggtaacccg cccaccgagc tgacgcagtc gcagatgctg      600

cacatcgctc agcaaatcgc agcaggcatg gtctacctgg catcccaaca cttcgtgcac      660

cgagacctgg ccacccggaa ctgcttggta ggagagaacc tgctggtgaa aattggggac      720

ttcgggatgt cccgggatgt atacagcacc gactactacc gggttggtgg ccacacaatg      780

ttgcccatcc gatggatgcc tccagagagc atcatgtaca ggaaattcac caccgagagt      840

gacgtctgga gcctgggagt tgtgttgtgg gagatcttca cctacggcaa gcagccctgg      900

tatcagctat caaacaacga ggtgatagaa tgcatcaccc agggcagagt ccttcagcgg      960

cctcgcacgt gtccccagga ggtgtacgag ctgatgctgg gatgctggca gcgggaacca     1020

cacacaagga agaacatcaa gaacatccac acactccttc agaacttggc gaaggcgtcg     1080

cccgtctacc tggacatcct aggc                                            1104


<210>  71
<211>  93
<212>  DNA
<213>  Homo sapiens

<400>  71
atgtcgtcct ggataaggtg gcatggaccc gccatggcgc ggctctgggg cttctgctgg       60

ctggttgtgg gcttctggag ggccgctttc gcc                                    93


<210>  72
<211>  1197
<212>  DNA
<213>  Homo sapiens

<400>  72
tgtcccacgt cctgcaaatg cagtgcctct cggatctggt gcagcgaccc ttctcctggc       60

atcgtggcat ttccgagatt ggagcctaac agtgtagatc ctgagaacat caccgaaatt      120

ttcatcgcaa accagaaaag gttagaaatc atcaacgaag atgatgttga agcttatgtg      180

ggactgagaa atctgacaat tgtggattct ggattaaaat ttgtggctca taaagcattt      240

ctgaaaaaca gcaacctgca gcacatcaat tttacccgaa acaaactgac gagtttgtct      300

aggaaacatt tccgtcacct tgacttgtct gaactgatcc tggtgggcaa tccatttaca      360

tgctcctgtg acattatgtg gatcaagact ctccaagagg ctaaatccag tccagacact      420

caggatttgt actgcctgaa tgaaagcagc aagaatattc ccctggcaaa cctgcagata      480

cccaattgtg gtttgccatc tgcaaatctg gccgcaccta acctcactgt ggaggaagga      540

aagtctatca cattatcctg tagtgtggca ggtgatccgg ttcctaatat gtattgggat      600

gttggtaacc tggtttccaa acatatgaat gaaacaagcc acacacaggg ctccttaagg      660

ataactaaca tttcatccga tgacagtggg aagcagatct cttgtgtggc ggaaaatctt      720

gtaggagaag atcaagattc tgtcaacctc actgtgcatt ttgcaccaac tatcacattt      780

ctcgaatctc caacctcaga ccaccactgg tgcattccat tcactgtgaa aggcaacccc      840

aaaccagcgc ttcagtggtt ctataacggg gcaatattga atgagtccaa atacatctgt      900

actaaaatac atgttaccaa tcacacggag taccacggct gcctccagct ggataatccc      960

actcacatga acaatgggga ctacactcta atagccaaga atgagtatgg gaaggatgag     1020

aaacagattt ctgctcactt catgggctgg cctggaattg acgatggtgc aaacccaaat     1080

tatcctgatg taatttatga agattatgga actgcagcga atgacatcgg ggacaccacg     1140

aacagaagta atgaaatccc ttccacagac gtcactgata aaaccggtcg ggaacat        1197


<210>  73
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  73
ctctcggtct atgctgtggt ggtgattgcg tctgtggtgg gattttgcct tttggtaatg       60

ctgtttctgc tt                                                           72


<210>  74
<211>  1152
<212>  DNA
<213>  Homo sapiens

<400>  74
aagttggcaa gacactccaa gtttggcatg aaagatttct catggtttgg atttgggaaa       60

gtaaaatcaa gacaaggtgt tggcccagcc tccgttatca gcaatgatga tgactctgcc      120

agcccactcc atcacatctc caatgggagt aacactccat cttcttcgga aggtggccca      180

gatgctgtca ttattggaat gaccaagatc cctgtcattg aaaatcccca gtactttggc      240

atcaccaaca gtcagctcaa gccagacaca tttgttcagc acatcaagcg acataacatt      300

gttctgaaaa gggagctagg cgaaggagcc tttggaaaag tgttcctagc tgaatgctat      360

aacctctgtc ctgagcagga caagatcttg gtggcagtga agaccctgaa ggatgccagt      420

gacaatgcac gcaaggactt ccaccgtgag gccgagctcc tgaccaacct ccagcatgag      480

cacatcgtca agttctatgg cgtctgcgtg gagggcgacc ccctcatcat ggtctttgag      540

tacatgaagc atggggacct caacaagttc ctcagggcac acggccctga tgccgtgctg      600

atggctgagg gcaacccgcc cacggaactg acgcagtcgc agatgctgca tatagcccag      660

cagatcgccg cgggcatggt ctacctggcg tcccagcact tcgtgcaccg cgatttggcc      720

accaggaact gcctggtcgg ggagaacttg ctggtgaaaa tcggggactt tgggatgtcc      780

cgggacgtgt acagcactga ctactacagg gtcggtggcc acacaatgct gcccattcgc      840

tggatgcctc cagagagcat catgtacagg aaattcacga cggaaagcga cgtctggagc      900

ctgggggtcg tgttgtggga gattttcacc tatggcaaac agccctggta ccagctgtca      960

aacaatgagg tgatagagtg tatcactcag ggccgagtcc tgcagcgacc ccgcacgtgc     1020

ccccaggagg tgtatgagct gatgctgggg tgctggcagc gagagcccca catgaggaag     1080

aacatcaagg gcatccatac cctccttcag aacttggcca aggcatctcc ggtctacctg     1140

gacattctag gc                                                         1152


<210>  75
<211>  822
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  Signal Peptide

<220>
<221>  MISC_FEATURE
<222>  (32)..(430)
<223>  Extracellular Domain

<220>
<221>  MISC_FEATURE
<222>  (431)..(454)
<223>  Transmembrane Domain

<220>
<221>  MISC_FEATURE
<222>  (455)..(822)
<223>  Cytoplasmic Domain

<400>  75

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  76
<211>  8498
<212>  DNA
<213>  Homo sapiens

<400>  76
cctcgaggtg cataccggac ccccattcgc atctaacaag gaatctgcgc cccagagagt       60

cccgggagcg ccgccggtcg gtgcccggcg cgccgggcca tgcagcgacg gccgccgcgg      120

agctccgagc agcggtagcg cccccctgta aagcggttcg ctatgccggg gccactgtga      180

accctgccgc ctgccggaac actcttcgct ccggaccagc tcagcctctg ataagctgga      240

ctcggcacgc ccgcaacaag caccgaggag ttaagagagc cgcaagcgca gggaaggcct      300

ccccgcacgg gtgggggaaa gcggccggtg cagcgcgggg acaggcactc gggctggcac      360

tggctgctag ggatgtcgtc ctggataagg tggcatggac ccgccatggc gcggctctgg      420

ggcttctgct ggctggttgt gggcttctgg agggccgctt tcgcctgtcc cacgtcctgc      480

aaatgcagtg cctctcggat ctggtgcagc gacccttctc ctggcatcgt ggcatttccg      540

agattggagc ctaacagtgt agatcctgag aacatcaccg aaattttcat cgcaaaccag      600

aaaaggttag aaatcatcaa cgaagatgat gttgaagctt atgtgggact gagaaatctg      660

acaattgtgg attctggatt aaaatttgtg gctcataaag catttctgaa aaacagcaac      720

ctgcagcaca tcaattttac ccgaaacaaa ctgacgagtt tgtctaggaa acatttccgt      780

caccttgact tgtctgaact gatcctggtg ggcaatccat ttacatgctc ctgtgacatt      840

atgtggatca agactctcca agaggctaaa tccagtccag acactcagga tttgtactgc      900

ctgaatgaaa gcagcaagaa tattcccctg gcaaacctgc agatacccaa ttgtggtttg      960

ccatctgcaa atctggccgc acctaacctc actgtggagg aaggaaagtc tatcacatta     1020

tcctgtagtg tggcaggtga tccggttcct aatatgtatt gggatgttgg taacctggtt     1080

tccaaacata tgaatgaaac aagccacaca cagggctcct taaggataac taacatttca     1140

tccgatgaca gtgggaagca gatctcttgt gtggcggaaa atcttgtagg agaagatcaa     1200

gattctgtca acctcactgt gcattttgca ccaactatca catttctcga atctccaacc     1260

tcagaccacc actggtgcat tccattcact gtgaaaggca accccaaacc agcgcttcag     1320

tggttctata acggggcaat attgaatgag tccaaataca tctgtactaa aatacatgtt     1380

accaatcaca cggagtacca cggctgcctc cagctggata atcccactca catgaacaat     1440

ggggactaca ctctaatagc caagaatgag tatgggaagg atgagaaaca gatttctgct     1500

cacttcatgg gctggcctgg aattgacgat ggtgcaaacc caaattatcc tgatgtaatt     1560

tatgaagatt atggaactgc agcgaatgac atcggggaca ccacgaacag aagtaatgaa     1620

atcccttcca cagacgtcac tgataaaacc ggtcgggaac atctctcggt ctatgctgtg     1680

gtggtgattg cgtctgtggt gggattttgc cttttggtaa tgctgtttct gcttaagttg     1740

gcaagacact ccaagtttgg catgaaaggc ccagcctccg ttatcagcaa tgatgatgac     1800

tctgccagcc cactccatca catctccaat gggagtaaca ctccatcttc ttcggaaggt     1860

ggcccagatg ctgtcattat tggaatgacc aagatccctg tcattgaaaa tccccagtac     1920

tttggcatca ccaacagtca gctcaagcca gacacatttg ttcagcacat caagcgacat     1980

aacattgttc tgaaaaggga gctaggcgaa ggagcctttg gaaaagtgtt cctagctgaa     2040

tgctataacc tctgtcctga gcaggacaag atcttggtgg cagtgaagac cctgaaggat     2100

gccagtgaca atgcacgcaa ggacttccac cgtgaggccg agctcctgac caacctccag     2160

catgagcaca tcgtcaagtt ctatggcgtc tgcgtggagg gcgaccccct catcatggtc     2220

tttgagtaca tgaagcatgg ggacctcaac aagttcctca gggcacacgg ccctgatgcc     2280

gtgctgatgg ctgagggcaa cccgcccacg gaactgacgc agtcgcagat gctgcatata     2340

gcccagcaga tcgccgcggg catggtctac ctggcgtccc agcacttcgt gcaccgcgat     2400

ttggccacca ggaactgcct ggtcggggag aacttgctgg tgaaaatcgg ggactttggg     2460

atgtcccggg acgtgtacag cactgactac tacagggtcg gtggccacac aatgctgccc     2520

attcgctgga tgcctccaga gagcatcatg tacaggaaat tcacgacgga aagcgacgtc     2580

tggagcctgg gggtcgtgtt gtgggagatt ttcacctatg gcaaacagcc ctggtaccag     2640

ctgtcaaaca atgaggtgat agagtgtatc actcagggcc gagtcctgca gcgaccccgc     2700

acgtgccccc aggaggtgta tgagctgatg ctggggtgct ggcagcgaga gccccacatg     2760

aggaagaaca tcaagggcat ccataccctc cttcagaact tggccaaggc atctccggtc     2820

tacctggaca ttctaggcta gggccctttt ccccagaccg atccttccca acgtactcct     2880

cagacgggct gagaggatga acatctttta actgccgctg gaggccacca agctgctctc     2940

cttcactctg acagtattaa catcaaagac tccgagaagc tctcgaggga agcagtgtgt     3000

acttcttcat ccatagacac agtattgact tctttttggc attatctctt tctctctttc     3060

catctccctt ggttgttcct ttttcttttt ttaaattttc tttttctttt ttttttcgtc     3120

ttccctgctt cacgattctt accctttctt ttgaatcaat ctggcttctg cattactatt     3180

aactctgcat agacaaaggc cttaacaaac gtaatttgtt atatcagcag acactccagt     3240

ttgcccacca caactaacaa tgccttgttg tattcctgcc tttgatgtgg atgaaaaaaa     3300

gggaaaacaa atatttcact taaactttgt cacttctgct gtacagatat cgagagtttc     3360

tatggattca cttctattta tttattatta ttactgttct tattgttttt ggatggctta     3420

agcctgtgta taaaaaagaa aacttgtgtt caatctgtga agcctttatc tatgggagat     3480

taaaaccaga gagaaagaag atttattatg aaccgcaata tgggaggaac aaagacaacc     3540

actgggatca gctggtgtca gtccctactt aggaaatact cagcaactgt tagctgggaa     3600

gaatgtattc ggcaccttcc cctgaggacc tttctgagga gtaaaaagac tactggcctc     3660

tgtgccatgg atgattcttt tcccatcacc agaaatgata gcgtgcagta gagagcaaag     3720

atggcttccg tgagacacaa gatggcgcat agtgtgctcg gacacagttt tgtcttcgta     3780

ggttgtgatg atagcactgg tttgtttctc aagcgctatc cacagaacct ttgtcaactt     3840

cagttgaaaa gaggtggatt catgtccaga gctcatttcg gggtcaggtg ggaaagccaa     3900

gaacttggaa aagataagac aagctataaa ttcggaggca agtttctttt acaatgaact     3960

tttcagatct cacttccctc cgacccctaa cttccatgcc cacccgtcct tttaactgtg     4020

caagcaaaat tgtgcatggt cttcgtcgat taataccttg tgtgcagaca ctactgctcc     4080

agacgtcgtt tccctgatag gtagagcaga tccataaaaa ggtatgactt atacaattag     4140

gggaagctaa tggagtttat tagctgagta tcaatgtctc tgcgttgtac ggtggtgatg     4200

ggttttaatg aatatggacc ctgaagcctg gaaatcctca tccacgtcga acccacagga     4260

ctgtgggaag ggcagaatca atccctaagg gaaaggaaac ctcaccctga gggcatcaca     4320

tgcactcatg ttcagtgtac acaggtcaag tcccttgctc tgggctctag ttgggagagt     4380

ggtttcattc caagtgtact ccattgtcag tatgctgttt ttgtttcctt cactccattc     4440

aaaaagtcaa aatacaaaat ttggcacagc atgccaacgg gaggctgtgc ccagaccaag     4500

cactggaagt gtgcttctag gcatagtcat tggttttgca aaaagagggc tcaaatttaa     4560

atagaaattt acagctattt gaatggtcag atataccaag aaagaaaaat atttctgttc     4620

ctcaagaaaa cttgctaccc tctgtgaggg gaattttgct aaacttgaca tctttataac     4680

atgagccaga ttgaaaggga gtgattttca ttcatcttag gtcatgttat ttcatatttg     4740

tttctgaagg tgcgatagct ctgttttagg ttttgcttgc gcctgttaat tactggaaca     4800

ccttattttt cattaaaggc tttgaaagcc aattctcaaa aattcaaaag tgcaaattaa     4860

cagaacaaaa ggaaatccag tagcaactgc agtcaagcga gggagttgac aagataaacc     4920

ttacgtccat tcaagttata tgctggccta tgagagatga gagttgggtc gtttgttctc     4980

tttgttgatg attttaaaaa aaccctctag aatacacata ataacataat gaaagccata     5040

tctccatgat atatatgtgc acatatatat acatacatgt gcatgtatgt atcatattaa     5100

ggacccatgg tactcttaaa acactgtaga actctgtgac gcagtaagga aggggcagat     5160

ttgtacaaaa acttttctag attccatcag caaaaaccaa cacaggtttg tcacgctgca     5220

tgtctggcca gctaatctcg ggggaaaagc tacaagttat ttattttatt ttaagagaat     5280

aaagtaggta ataatttaag ggatcaaatt caaggaggaa tgtgcaattt tagagcaaag     5340

atttgtttaa ggcaaatgag actttgggag catcccattc cagttttgtc ttttttttct     5400

ctgaaagaaa aaagcaaaaa ataaaataaa attccactta taccttctga caagtcccta     5460

aaggtcttga aataaaaggt tctatgcaag tgcaaagttt tatagttatt tttattgctg     5520

attattacta ttactatctc tgttgtctta agagtatgtg ctgatttcag agacatctca     5580

aattgaaaga atatcagatt gcttttaaag tagctgaacg agccacagaa tatctgaaat     5640

tattcattgt tgttcctcca ccaccccctt tctcatggtc tgatttttag aagagtggca     5700

tcctcgttct aaaatgtaat gatcaccaaa tacggccttc catcaaattt gtgaaaacta     5760

caacagtata acagtgacaa acctaattct ctagcccaaa cctggtctga caatcatttc     5820

catttagaag tcattgaata gttttccaaa cactttccat gtgtgttagc aaattattcc     5880

tattttgtgt agatgaggac gttgagactc agagacattc agaggcacgc tagaggtctc     5940

cagcctagct tccagcacca ttgggactga atccaagtac tctcactctg aacttcgtgg     6000

ttctgtccac tagagactct aatatgcaaa caagcagttc aggaaagaaa gcatgctaac     6060

acattcatga agcagtatat gaagttagaa gaacaaaagg aaatacagga gatgacaagc     6120

aactgagata ttgtgatata taatcatgct cttagcttca gctaaattca gctaaattct     6180

tgtacactga accaatgtca taatcaggct tatttagaaa acactttgaa ctatgctata     6240

aaagattata tcagaattca tattatacat gtgttcacat cagcgctacc tgtgatgttt     6300

tcatgtattt atgtatgtgt tataaatact tgatttatac atatacaaat gcacatacgt     6360

agtgtgtttg tgtgtttatg tataaattta taggcacaca ataatagagg taattataag     6420

taggatgcgg tatgaataat ttgcttaaaa tatgctaaat aaccaaaact gtttaacgtc     6480

atgttgctgt tagtgcttcc atactccacg tgggtaggac tacatcacac ttttcaactc     6540

tgtgcagtac tgcatgggtg gaagacatat ttaagataat gtgcttccca aaacaactga     6600

ataaaagcca tcccactaca ttgagtgctt tctctggctc cttgcaaaga aagatacttt     6660

ttgtaatggt ccaggaaagg aacattgctt tctttttgtc tttcagcaca tttgtattat     6720

gctcaccttg tctctgtctc actgtgaccc ctttacactt gagttcagag ttcaagcatt     6780

ccaaatataa attggaatgt tggcagccca gtggcttgaa ggccaatgat gagcagtcca     6840

agaccccaca gcgagatgag caactcttag gaattcccac atcctagagt gaatgcacca     6900

actaacagta tagaatgctg tccttttcaa agcgtcctaa cagcaggatt acctggtcaa     6960

gtatggactt tctttgaatc tttcttttca caaattggac tgcctgtaat accaataaca     7020

ttgttgtatc taactaaata aatgactgca tatacacaca taccctcaat tctcttgctt     7080

ccccattttc tttttcatcc cctgtctcag gacttttatt ttcaatgttg acctttggtt     7140

tggccatata tcactgttat aggaaatctc atgagaggaa tggctagtga cccaactctc     7200

caaatgtcta agttagtagt tacagctgat tttttatgat gcataattgg aatgtggagc     7260

ctctgaggtt gtgatagctt gtacatgaat ttcaaatgtc attctaaaga atgaggggtg     7320

ggagggattt atagttagaa acgacagtgc aggaaggggt attttcttgt tgtcagggct     7380

ggaatgaatc actgctgctc aagtcaaagg ttcttgaata tccttagttt ttgcatttcc     7440

cctccttttc ctttgacctt tatttattta attatgtatt tatttattta tttatatact     7500

tttgctccat tcagcacaaa cacaaagcaa agcaaaaaaa aaaatatata tatatatatc     7560

tgtatatgtg ttgtaggcaa aacactgtga atttcacaac aaccaccacc aagcaactat     7620

tttgccatct taacatacat ctcaggagac gaaatgagaa aagatgggga tgtcattttt     7680

tagtctatgc gtttgaggcc aggtccatgt ttatttattt ctttagtcta tgcattaatg     7740

aaaatgatcc tgagtggagg ttagctgaac gttcaatgta ctggagcaag catcataaaa     7800

gctgctagta gccatgtgtt tgaacaggaa aaatattaca gaaaatgaaa tgtaaaggcc     7860

tatatcttgc agcttgtata tcttactatt gcttaaaaaa tgtataaagc agctggaaat     7920

gttttaaata caaggtcttt gaattaaatg tggattttaa atatgtaatc ccttgacaaa     7980

tgaccaaatt atggtgaact attgctccct gcgttctttg atcattacct atgacttaca     8040

aatctgcctg gagatgtgga cattctgcat ttgcttctgt atctggagag atgtttgtat     8100

atatccaggc cgtatacaca cacatttcca tatctctcta cagatatatt tccccttcaa     8160

tcgtgacctg gtatttggaa ctctcctttt catttggctt atcttccttt taatgtgatg     8220

tctctgtgct aatacttacc agttcttgtt ttgcaatctg ttttgaggtc cattgcttta     8280

ctaagaccca ctgcatcttg gctgatttca aagtgacacc tgaatacagt gtttaaaaaa     8340

aaaaaagttt tgtttgtaaa tcatgtgacc agcttctctc aacctgacat ggaaagtctc     8400

ttgtactaca gtgtatttaa taaaaatgat gtcttacaat aaataacata ctccaaaaga     8460

gagactaaaa atgaaaaaaa aaaaaaaaaa aaaaaaaa                             8498


<210>  77
<211>  2469
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(93)
<223>  Signal Peptide

<220>
<221>  misc_feature
<222>  (94)..(1290)
<223>  Extracellular Domain

<220>
<221>  misc_feature
<222>  (1291)..(1362)
<223>  Transmembrane Domain

<220>
<221>  misc_feature
<222>  (1363)..(2466)
<223>  Cytoplasmic Domain

<400>  77
atgtcgtcct ggataaggtg gcatggaccc gccatggcgc ggctctgggg cttctgctgg       60

ctggttgtgg gcttctggag ggccgctttc gcctgtccca cgtcctgcaa atgcagtgcc      120

tctcggatct ggtgcagcga cccttctcct ggcatcgtgg catttccgag attggagcct      180

aacagtgtag atcctgagaa catcaccgaa attttcatcg caaaccagaa aaggttagaa      240

atcatcaacg aagatgatgt tgaagcttat gtgggactga gaaatctgac aattgtggat      300

tctggattaa aatttgtggc tcataaagca tttctgaaaa acagcaacct gcagcacatc      360

aattttaccc gaaacaaact gacgagtttg tctaggaaac atttccgtca ccttgacttg      420

tctgaactga tcctggtggg caatccattt acatgctcct gtgacattat gtggatcaag      480

actctccaag aggctaaatc cagtccagac actcaggatt tgtactgcct gaatgaaagc      540

agcaagaata ttcccctggc aaacctgcag atacccaatt gtggtttgcc atctgcaaat      600

ctggccgcac ctaacctcac tgtggaggaa ggaaagtcta tcacattatc ctgtagtgtg      660

gcaggtgatc cggttcctaa tatgtattgg gatgttggta acctggtttc caaacatatg      720

aatgaaacaa gccacacaca gggctcctta aggataacta acatttcatc cgatgacagt      780

gggaagcaga tctcttgtgt ggcggaaaat cttgtaggag aagatcaaga ttctgtcaac      840

ctcactgtgc attttgcacc aactatcaca tttctcgaat ctccaacctc agaccaccac      900

tggtgcattc cattcactgt gaaaggcaac cccaaaccag cgcttcagtg gttctataac      960

ggggcaatat tgaatgagtc caaatacatc tgtactaaaa tacatgttac caatcacacg     1020

gagtaccacg gctgcctcca gctggataat cccactcaca tgaacaatgg ggactacact     1080

ctaatagcca agaatgagta tgggaaggat gagaaacaga tttctgctca cttcatgggc     1140

tggcctggaa ttgacgatgg tgcaaaccca aattatcctg atgtaattta tgaagattat     1200

ggaactgcag cgaatgacat cggggacacc acgaacagaa gtaatgaaat cccttccaca     1260

gacgtcactg ataaaaccgg tcgggaacat ctctcggtct atgctgtggt ggtgattgcg     1320

tctgtggtgg gattttgcct tttggtaatg ctgtttctgc ttaagttggc aagacactcc     1380

aagtttggca tgaaaggccc agcctccgtt atcagcaatg atgatgactc tgccagccca     1440

ctccatcaca tctccaatgg gagtaacact ccatcttctt cggaaggtgg cccagatgct     1500

gtcattattg gaatgaccaa gatccctgtc attgaaaatc cccagtactt tggcatcacc     1560

aacagtcagc tcaagccaga cacatttgtt cagcacatca agcgacataa cattgttctg     1620

aaaagggagc taggcgaagg agcctttgga aaagtgttcc tagctgaatg ctataacctc     1680

tgtcctgagc aggacaagat cttggtggca gtgaagaccc tgaaggatgc cagtgacaat     1740

gcacgcaagg acttccaccg tgaggccgag ctcctgacca acctccagca tgagcacatc     1800

gtcaagttct atggcgtctg cgtggagggc gaccccctca tcatggtctt tgagtacatg     1860

aagcatgggg acctcaacaa gttcctcagg gcacacggcc ctgatgccgt gctgatggct     1920

gagggcaacc cgcccacgga actgacgcag tcgcagatgc tgcatatagc ccagcagatc     1980

gccgcgggca tggtctacct ggcgtcccag cacttcgtgc accgcgattt ggccaccagg     2040

aactgcctgg tcggggagaa cttgctggtg aaaatcgggg actttgggat gtcccgggac     2100

gtgtacagca ctgactacta cagggtcggt ggccacacaa tgctgcccat tcgctggatg     2160

cctccagaga gcatcatgta caggaaattc acgacggaaa gcgacgtctg gagcctgggg     2220

gtcgtgttgt gggagatttt cacctatggc aaacagccct ggtaccagct gtcaaacaat     2280

gaggtgatag agtgtatcac tcagggccga gtcctgcagc gaccccgcac gtgcccccag     2340

gaggtgtatg agctgatgct ggggtgctgg cagcgagagc cccacatgag gaagaacatc     2400

aagggcatcc ataccctcct tcagaacttg gccaaggcat ctccggtcta cctggacatt     2460

ctaggctag                                                             2469


<210>  78
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cagcttcagt agctttggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtgtcagtt atatcatatg atggaattaa tacatactat      180

acagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acggcctgag agctgaggac acggctcttt attactgtgt gcaagggtca      300

attggaaccg tttttgaata ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  79
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Tyr Asp Gly Ile Asn Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Gln Gly Ser Ile Gly Thr Val Phe Glu Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  80
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
ggattcagct tcagtagctt tggc                                              24


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Gly Phe Ser Phe Ser Ser Phe Gly 
1               5               


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
atatcatatg atggaattaa taca                                              24


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Ile Ser Tyr Asp Gly Ile Asn Thr 
1               5               


<210>  84
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
gtgcaagggt caattggaac cgtttttgaa tac                                    33


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

Val Gln Gly Ser Ile Gly Thr Val Phe Glu Tyr 
1               5                   10      


<210>  86
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gggcattagc aattatttag cctggtatca gcagaaacca      120

gggaaagttc ctaaactcct gatctatgct gcatccactt tacaatcagg ggtcccatct      180

cggttcggtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagatgttg caacttatta ctgtcaaaag tataccagtg ccccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  87
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Thr Ser Ala Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  88
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
cagggcatta gcaattat                                                     18


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  90
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
gctgcatcc                                                                9


<210>  91
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91

Ala Ala Ser 
1           


<210>  92
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
caaaagtata ccagtgcccc attcact                                           27


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  93

Gln Lys Tyr Thr Ser Ala Pro Phe Thr 
1               5                   


<210>  94
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  94
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctaaaactc       60

tcctgtacag cctctgggtt caccttcagt ggctctgtta ttcactgggt ccgccaggct      120

tccgggaaag ggctggagtg gattggccgt attagaaaca aggctaacag ttacgcgaca      180

gcatatggtg cgtcggtgac aggcaggttc accatctcca gagatgattc aaagaacacg      240

gcgtatctgc aaatgaacag cctgaaaacc gaggacacgg ccgtttatta ctgtactttc      300

ccgggtgtag tgggacgagg aggttttgac tactggggcc agggcaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  95
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Arg Asn Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Gly Ala 
    50                  55                  60                  


Ser Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Phe Pro Gly Val Val Gly Arg Gly Gly Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  96
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  96
gggttcacct tcagtggctc tgtt                                              24


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97

Gly Phe Thr Phe Ser Gly Ser Val 
1               5               


<210>  98
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
attagaaaca aggctaacag ttacgcgaca                                        30


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99

Ile Arg Asn Lys Ala Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  100
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100
actttcccgg gtgtagtggg acgaggaggt tttgactac                              39


<210>  101
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101

Thr Phe Pro Gly Val Val Gly Arg Gly Gly Phe Asp Tyr 
1               5                   10              


<210>  102
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gggggccacc       60

atcaactgca tgtccagcca gagtgtttta ttcagctcca acaataagaa ctacttagct      120

tggtaccaac agaaaccagg acagcctcct aagttgctct tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcggtggc agcgggtctg ggacagattt ctctctcacc      240

atcaacagcc tgcagactga agatgtggca gtttattact gtctccaata ttatagtatt      300

ccgtggacgt tcggccaagg gaccaaggtg gaaatcaaa                             339


<210>  103
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Gly Ala Thr Ile Asn Cys Met Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Phe Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 
65                  70                  75                  80  


Ile Asn Ser Leu Gln Thr Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln 
                85                  90                  95      


Tyr Tyr Ser Ile Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  104
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104
cagagtgttt tattcagctc caacaataag aactac                                 36


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105

Gln Ser Val Leu Phe Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  106
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106
tgggcatct                                                                9


<210>  107
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107

Trp Ala Ser 
1           


<210>  108
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  108
ctccaatatt atagtattcc gtggacg                                           27


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  109

Leu Gln Tyr Tyr Ser Ile Pro Trp Thr 
1               5                   


<210>  110
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  110
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgacactc       60

tcctgtgcag cctctggatt caatttccgt gattatgaaa tgatctgggt ccgccagact      120

ccagggaagg ggctggagtg gatttcatac attagtaata gtggttatac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaggaa ctcaatatat      240

ctgcaagtga acagcctgag agccgaggac acggctgttt attactgttc gagacgtact      300

actatgattc ggggcattag ggcgtactac tattacggtc tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210>  111
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Arg Asp Tyr 
            20                  25                  30          


Glu Met Ile Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Asn Ser Gly Tyr Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Ile Tyr 
65                  70                  75                  80  


Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Arg Thr Thr Met Ile Arg Gly Ile Arg Ala Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  112
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
ggattcaatt tccgtgatta tgaa                                              24


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  113

Gly Phe Asn Phe Arg Asp Tyr Glu 
1               5               


<210>  114
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  114
attagtaata gtggttatac cata                                              24


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  115

Ile Ser Asn Ser Gly Tyr Thr Ile 
1               5               


<210>  116
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  116
tcgagacgta ctactatgat tcggggcatt agggcgtact actattacgg tctggacgtc       60


<210>  117
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  117

Ser Arg Arg Thr Thr Met Ile Arg Gly Ile Arg Ala Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Leu Asp Val 
            20  


<210>  118
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  118
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccgtca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgat caccttcggc      300

caagggacac gactggagat taaa                                             324


<210>  119
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  119

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  120
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  120
cagagcatta gcagctat                                                     18


<210>  121
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  121

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  122
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  122
gctgcatcc                                                                9


<210>  123
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123

Ala Ala Ser 
1           


<210>  124
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
caacagagtt acagtacccc tccgatcacc                                        30


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


