                         SEQUENCE LISTING

<110>  MILLENNIUM PHARMACEUTICALS, INC.
      
<120>  BIOMARKERS AND METHODS FOR TREATMENT WITH NAE INHIBITORS

<130>  3817.041PC01

<150>  62/593,686
<151>  2017-12-01

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  9796
<212>  DNA
<213>  Homo sapiens

<400>  1
ggcagtggca gcggcgagag cttgggcggc cgccgccgcc tcctcgcgag cgccgcgcgc       60

ccgggtcccg ctcgcatgca agtcacgtcc gccccctcgg cgcggccgcc ccgagacgcc      120

ggccccgctg agtgatgaga acagacgtca aactgcctta tgaatattga tgcggaggct      180

aggctgcttt cgtagagaag cagaaggaag caagatggct gccctttagg atttgttaga      240

aaggagaccc gactgcaact gctggattgc tgcaaggctg agggacgaga acgaggctgg      300

caaacattca gcagcacacc ctctcaagat tgtttacttg cctttgctcc tgttgagtta      360

caacgcttgg aagcaggaga tgggctcagc agcagccaat aggacatgat ccaggaagag      420

cagtaaggga ctgagctgct gaattcaact agagggcagc cttgtggatg gccccgaagc      480

aagcctgatg gaacaggata gaaccaacca tgttgagggc aacagactaa gtccattcct      540

gataccatca cctcccattt gccagacaga acctctggct acaaagctcc agaatggaag      600

cccactgcct gagagagctc atccagaagt aaatggagac accaagtggc actctttcaa      660

aagttattat ggaataccct gtatgaaggg aagccagaat agtcgtgtga gtcctgactt      720

tacacaagaa agtagagggt attccaagtg tttgcaaaat ggaggaataa aacgcacagt      780

tagtgaacct tctctctctg ggctccttca gatcaagaaa ttgaaacaag accaaaaggc      840

taatggagaa agacgtaact tcggggtaag ccaagaaaga aatccaggtg aaagcagtca      900

accaaatgtc tccgatttga gtgataagaa agaatctgtg agttctgtag cccaagaaaa      960

tgcagttaaa gatttcacca gtttttcaac acataactgc agtgggcctg aaaatccaga     1020

gcttcagatt ctgaatgagc aggaggggaa aagtgctaat taccatgaca agaacattgt     1080

attacttaaa aacaaggcag tgctaatgcc taatggtgct acagtttctg cctcttccgt     1140

ggaacacaca catggtgaac tcctggaaaa aacactgtct caatattatc cagattgtgt     1200

ttccattgcg gtgcagaaaa ccacatctca cataaatgcc attaacagtc aggctactaa     1260

tgagttgtcc tgtgagatca ctcacccatc gcatacctca gggcagatca attccgcaca     1320

gacctctaac tctgagctgc ctccaaagcc agctgcagtg gtgagtgagg cctgtgatgc     1380

tgatgatgct gataatgcca gtaaactagc tgcaatgcta aatacctgtt cctttcagaa     1440

accagaacaa ctacaacaac aaaaatcagt ttttgagata tgcccatctc ctgcagaaaa     1500

taacatccag ggaaccacaa agctagcgtc tggtgaagaa ttctgttcag gttccagcag     1560

caatttgcaa gctcctggtg gcagctctga acggtattta aaacaaaatg aaatgaatgg     1620

tgcttacttc aagcaaagct cagtgttcac taaggattcc ttttctgcca ctaccacacc     1680

accaccacca tcacaattgc ttctttctcc ccctcctcct cttccacagg ttcctcagct     1740

tccttcagaa ggaaaaagca ctctgaatgg tggagtttta gaagaacacc accactaccc     1800

caaccaaagt aacacaacac ttttaaggga agtgaaaata gagggtaaac ctgaggcacc     1860

accttcccag agtcctaatc catctacaca tgtatgcagc ccttctccga tgctttctga     1920

aaggcctcag aataattgtg tgaacaggaa tgacatacag actgcaggga caatgactgt     1980

tccattgtgt tctgagaaaa caagaccaat gtcagaacac ctcaagcata acccaccaat     2040

ttttggtagc agtggagagc tacaggacaa ctgccagcag ttgatgagaa acaaagagca     2100

agagattctg aagggtcgag acaaggagca aacacgagat cttgtgcccc caacacagca     2160

ctatctgaaa ccaggatgga ttgaattgaa ggcccctcgt tttcaccaag cggaatccca     2220

tctaaaacgt aatgaggcat cactgccatc aattcttcag tatcaaccca atctctccaa     2280

tcaaatgacc tccaaacaat acactggaaa ttccaacatg cctggggggc tcccaaggca     2340

agcttacacc cagaaaacaa cacagctgga gcacaagtca caaatgtacc aagttgaaat     2400

gaatcaaggg cagtcccaag gtacagtgga ccaacatctc cagttccaaa aaccctcaca     2460

ccaggtgcac ttctccaaaa cagaccattt accaaaagct catgtgcagt cactgtgtgg     2520

cactagattt cattttcaac aaagagcaga ttcccaaact gaaaaactta tgtccccagt     2580

gttgaaacag cacttgaatc aacaggcttc agagactgag ccattttcaa actcacacct     2640

tttgcaacat aagcctcata aacaggcagc acaaacacaa ccatcccaga gttcacatct     2700

ccctcaaaac cagcaacagc agcaaaaatt acaaataaag aataaagagg aaatactcca     2760

gacttttcct cacccccaaa gcaacaatga tcagcaaaga gaaggatcat tctttggcca     2820

gactaaagtg gaagaatgtt ttcatggtga aaatcagtat tcaaaatcaa gcgagttcga     2880

gactcataat gtccaaatgg gactggagga agtacagaat ataaatcgta gaaattcccc     2940

ttatagtcag accatgaaat caagtgcatg caaaatacag gtttcttgtt caaacaatac     3000

acacctagtt tcagagaata aagaacagac tacacatcct gaactttttg caggaaacaa     3060

gacccaaaac ttgcatcaca tgcaatattt tccaaataat gtgatcccaa agcaagatct     3120

tcttcacagg tgctttcaag aacaggagca gaagtcacaa caagcttcag ttctacaggg     3180

atataaaaat agaaaccaag atatgtctgg tcaacaagct gcgcaacttg ctcagcaaag     3240

gtacttgata cataaccatg caaatgtttt tcctgtgcct gaccagggag gaagtcacac     3300

tcagacccct ccccagaagg acactcaaaa gcatgctgct ctaaggtggc atctcttaca     3360

gaagcaagaa cagcagcaaa cacagcaacc ccaaactgag tcttgccata gtcagatgca     3420

caggccaatt aaggtggaac ctggatgcaa gccacatgcc tgtatgcaca cagcaccacc     3480

agaaaacaaa acatggaaaa aggtaactaa gcaagagaat ccacctgcaa gctgtgataa     3540

tgtgcagcaa aagagcatca ttgagaccat ggagcagcat ctgaagcagt ttcacgccaa     3600

gtcgttattt gaccataagg ctcttactct caaatcacag aagcaagtaa aagttgaaat     3660

gtcagggcca gtcacagttt tgactagaca aaccactgct gcagaacttg atagccacac     3720

cccagcttta gagcagcaaa caacttcttc agaaaagaca ccaaccaaaa gaacagctgc     3780

ttctgttctc aataatttta tagagtcacc ttccaaatta ctagatactc ctataaaaaa     3840

tttattggat acacctgtca agactcaata tgatttccca tcttgcagat gtgtagagca     3900

aattattgaa aaagatgaag gtccttttta tacccatcta ggagcaggtc ctaatgtggc     3960

agctattaga gaaatcatgg aagaaaggtt tggacagaag ggtaaagcta ttaggattga     4020

aagagtcatc tatactggta aagaaggcaa aagttctcag ggatgtccta ttgctaagtg     4080

ggtggttcgc agaagcagca gtgaagagaa gctactgtgt ttggtgcggg agcgagctgg     4140

ccacacctgt gaggctgcag tgattgtgat tctcatcctg gtgtgggaag gaatcccgct     4200

gtctctggct gacaaactct actcggagct taccgagacg ctgaggaaat acggcacgct     4260

caccaatcgc cggtgtgcct tgaatgaaga gagaacttgc gcctgtcagg ggctggatcc     4320

agaaacctgt ggtgcctcct tctcttttgg ttgttcatgg agcatgtact acaatggatg     4380

taagtttgcc agaagcaaga tcccaaggaa gtttaagctg cttggggatg acccaaaaga     4440

ggaagagaaa ctggagtctc atttgcaaaa cctgtccact cttatggcac caacatataa     4500

gaaacttgca cctgatgcat ataataatca gattgaatat gaacacagag caccagagtg     4560

ccgtctgggt ctgaaggaag gccgtccatt ctcaggggtc actgcatgtt tggacttctg     4620

tgctcatgcc cacagagact tgcacaacat gcagaatggc agcacattgg tatgcactct     4680

cactagagaa gacaatcgag aatttggagg aaaacctgag gatgagcagc ttcacgttct     4740

gcctttatac aaagtctctg acgtggatga gtttgggagt gtggaagctc aggaggagaa     4800

aaaacggagt ggtgccattc aggtactgag ttcttttcgg cgaaaagtca ggatgttagc     4860

agagccagtc aagacttgcc gacaaaggaa actagaagcc aagaaagctg cagctgaaaa     4920

gctttcctcc ctggagaaca gctcaaataa aaatgaaaag gaaaagtcag ccccatcacg     4980

tacaaaacaa actgaaaacg caagccaggc taaacagttg gcagaacttt tgcgactttc     5040

aggaccagtc atgcagcagt cccagcagcc ccagcctcta cagaagcagc caccacagcc     5100

ccagcagcag cagagacccc agcagcagca gccacatcac cctcagacag agtctgtcaa     5160

ctcttattct gcttctggat ccaccaatcc atacatgaga cggcccaatc cagttagtcc     5220

ttatccaaac tcttcacaca cttcagatat ctatggaagc accagcccta tgaacttcta     5280

ttccacctca tctcaagctg caggttcata tttgaattct tctaatccca tgaaccctta     5340

ccctgggctt ttgaatcaga atacccaata tccatcatat caatgcaatg gaaacctatc     5400

agtggacaac tgctccccat atctgggttc ctattctccc cagtctcagc cgatggatct     5460

gtataggtat ccaagccaag accctctgtc taagctcagt ctaccaccca tccatacact     5520

ttaccagcca aggtttggaa atagccagag ttttacatct aaatacttag gttatggaaa     5580

ccaaaatatg cagggagatg gtttcagcag ttgtaccatt agaccaaatg tacatcatgt     5640

agggaaattg cctccttatc ccactcatga gatggatggc cacttcatgg gagccacctc     5700

tagattacca cccaatctga gcaatccaaa catggactat aaaaatggtg aacatcattc     5760

accttctcac ataatccata actacagtgc agctccgggc atgttcaaca gctctcttca     5820

tgccctgcat ctccaaaaca aggagaatga catgctttcc cacacagcta atgggttatc     5880

aaagatgctt ccagctctta accatgatag aactgcttgt gtccaaggag gcttacacaa     5940

attaagtgat gctaatggtc aggaaaagca gccattggca ctagtccagg gtgtggcttc     6000

tggtgcagag gacaacgatg aggtctggtc agacagcgag cagagctttc tggatcctga     6060

cattggggga gtggccgtgg ctccaactca tgggtcaatt ctcattgagt gtgcaaagcg     6120

tgagctgcat gccacaaccc ctttaaagaa tcccaatagg aatcacccca ccaggatctc     6180

cctcgtcttt taccagcata agagcatgaa tgagccaaaa catggcttgg ctctttggga     6240

agccaaaatg gctgaaaaag cccgtgagaa agaggaagag tgtgaaaagt atggcccaga     6300

ctatgtgcct cagaaatccc atggcaaaaa agtgaaacgg gagcctgctg agccacatga     6360

aacttcagag cccacttacc tgcgtttcat caagtctctt gccgaaagga ccatgtccgt     6420

gaccacagac tccacagtaa ctacatctcc atatgccttc actcgggtca cagggcctta     6480

caacagatat atatgatatc accccctttt gttggttacc tcacttgaaa agaccacaac     6540

caacctgtca gtagtatagt tctcatgacg tgggcagtgg ggaaaggtca cagtattcat     6600

gacaaatgtg gtgggaaaaa cctcagctca ccagcaacaa aagaggttat cttaccatag     6660

cacttaattt tcactggctc ccaagtggtc acagatggca tctaggaaaa gaccaaagca     6720

ttctatgcaa aaagaaggtg gggaagaaag tgttccgcaa tttacatttt taaacactgg     6780

ttctattatt ggacgagatg atatgtaaat gtgatccccc ccccccgctt acaactctac     6840

acatctgtga ccacttttaa taatatcaag tttgcatagt catggaacac aaatcaaaca     6900

agtactgtag tattacagtg acaggaatct taaaatacca tctggtgctg aatatatgat     6960

gtactgaaat actggaatta tggctttttg aaatgcagtt tttactgtaa tcttaacttt     7020

tatttatcaa aatagctaca ggaaacatga atagcaggaa aacactgaat ttgtttggat     7080

gttctaagaa atggtgctaa gaaaatggtg tctttaatag ctaaaaattt aatgccttta     7140

tatcatcaag atgctatcag tgtactccag tgcccttgaa taataggggt accttttcat     7200

tcaagttttt atcataatta cctattctta cacaagctta gtttttaaaa tgtggacatt     7260

ttaaaggcct ctggattttg ctcatccagt gaagtccttg taggacaata aacgtatata     7320

tgtacatata tacacaaaca tgtatatgtg cacacacatg tatatgtata aatattttaa     7380

atggtgtttt agaagcactt tgtctaccta agctttgaca acttgaacaa tgctaaggta     7440

ctgagatgtt taaaaaacaa gtttactttc attttagaat gcaaagttga tttttttaag     7500

gaaacaaaga aagcttttaa aatatttttg cttttagcca tgcatctgct gatgagcaat     7560

tgtgtccatt tttaacacag ccagttaaat ccaccatggg gcttactgga ttcaagggaa     7620

tacgttagtc cacaaaacat gttttctggt gctcatctca catgctatac tgtaaaacag     7680

ttttatacaa aattgtatga caagttcatt gctcaaaaat gtacagtttt aagaattttc     7740

tattaactgc aggtaataat tagctgcatg ctgcagactc aacaaagcta gttcactgaa     7800

gcctatgcta ttttatggat cataggctct tcagagaact gaatggcagt ctgcctttgt     7860

gttgataatt atgtacattg tgacgttgtc atttcttagc ttaagtgtcc tctttaacaa     7920

gaggattgag cagactgatg cctgcataag atgaataaac agggttagtt ccatgtgaat     7980

ctgtcagtta aaaagaaaca aaaacaggca gctggtttgc tgtggtggtt ttaaatcatt     8040

aatttgtata aagaagtgaa agagttgtat agtaaattaa attgtaaaca aaactttttt     8100

aatgcaatgc tttagtattt tagtactgta aaaaaattaa atatatacat atatatatat     8160

atatatatat atatatatat gagtttgaag cagaattcac atcatgatgg tgctactcag     8220

cctgctacaa atatatcata atgtgagcta agaattcatt aaatgtttga gtgatgttcc     8280

tacttgtcat atacctcaac actagtttgg caataggata ttgaactgag agtgaaagca     8340

ttgtgtacca tcattttttt ccaagtcctt ttttttattg ttaaaaaaaa aagcatacct     8400

tttttcaata cttgatttct tagcaagtat aacttgaact tcaacctttt tgttctaaaa     8460

attcagggat atttcagctc atgctctccc tatgccaaca tgtcacctgt gtttatgtaa     8520

aattgttgta ggttaataaa tatattcttt gtcagggatt taaccctttt attttgaatc     8580

ccttctattt tacttgtaca tgtgctgatg taactaaaac taattttgta aatctgttgg     8640

ctctttttat tgtaaagaaa agcattttaa aagtttgagg aatcttttga ctgtttcaag     8700

caggaaaaaa aaattacatg aaaatagaat gcactgagtt gataaaggga aaaattgtaa     8760

ggcaggagtt tggcaagtgg ctgttggcca gagacttact tgtaactctc taaatgaagt     8820

ttttttgatc ctgtaatcac tgaaggtaca tactccatgt ggacttccct taaacaggca     8880

aacacctaca ggtatggtgt gcaacagatt gtacaattac attttggcct aaatacattt     8940

ttgcttacta gtatttaaaa taaattctta atcagaggag gcctttgggt tttattggtc     9000

aaatctttgt aagctggctt ttgtcttttt aaaaaatttc ttgaatttgt ggttgtgtcc     9060

aatttgcaaa catttccaaa aatgtttgct ttgcttacaa accacatgat tttaatgttt     9120

tttgtatacc ataatatcta gccccaaaca tttgattact acatgtgcat tggtgatttt     9180

gatcatccat tcttaatatt tgatttctgt gtcacctact gtcatttgtt aaactgctgg     9240

ccaacaagaa caggaagtat agtttggggg gttggggaga gtttacataa ggaagagaag     9300

aaattgagtg gcatattgta aatatcagat ctataattgt aaatataaaa cctgcctcag     9360

ttagaatgaa tggaaagcag atctacaatt tgctaatata ggaatatcag gttgactata     9420

tagccatact tgaaaatgct tctgagtggt gtcaacttta cttgaatgaa tttttcatct     9480

tgattgacgc acagtgatgt acagttcact tctgaagcta gtggttaact tgtgtaggaa     9540

acttttgcag tttgacacta agataacttc tgtgtgcatt tttctatgct tttttaaaaa     9600

ctagtttcat ttcattttca tgagatgttt ggtttataag atctgaggat ggttataaat     9660

actgtaagta ttgtaatgtt atgaatgcag gttatttgaa agctgtttat tattatatca     9720

ttcctgataa tgctatgtga gtgtttttaa taaaatttat atttatttaa tgcactctaa     9780

aaaaaaaaaa aaaaaa                                                     9796


<210>  2
<211>  2002
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gln Asp Arg Thr Asn His Val Glu Gly Asn Arg Leu Ser Pro 
1               5                   10                  15      


Phe Leu Ile Pro Ser Pro Pro Ile Cys Gln Thr Glu Pro Leu Ala Thr 
            20                  25                  30          


Lys Leu Gln Asn Gly Ser Pro Leu Pro Glu Arg Ala His Pro Glu Val 
        35                  40                  45              


Asn Gly Asp Thr Lys Trp His Ser Phe Lys Ser Tyr Tyr Gly Ile Pro 
    50                  55                  60                  


Cys Met Lys Gly Ser Gln Asn Ser Arg Val Ser Pro Asp Phe Thr Gln 
65                  70                  75                  80  


Glu Ser Arg Gly Tyr Ser Lys Cys Leu Gln Asn Gly Gly Ile Lys Arg 
                85                  90                  95      


Thr Val Ser Glu Pro Ser Leu Ser Gly Leu Leu Gln Ile Lys Lys Leu 
            100                 105                 110         


Lys Gln Asp Gln Lys Ala Asn Gly Glu Arg Arg Asn Phe Gly Val Ser 
        115                 120                 125             


Gln Glu Arg Asn Pro Gly Glu Ser Ser Gln Pro Asn Val Ser Asp Leu 
    130                 135                 140                 


Ser Asp Lys Lys Glu Ser Val Ser Ser Val Ala Gln Glu Asn Ala Val 
145                 150                 155                 160 


Lys Asp Phe Thr Ser Phe Ser Thr His Asn Cys Ser Gly Pro Glu Asn 
                165                 170                 175     


Pro Glu Leu Gln Ile Leu Asn Glu Gln Glu Gly Lys Ser Ala Asn Tyr 
            180                 185                 190         


His Asp Lys Asn Ile Val Leu Leu Lys Asn Lys Ala Val Leu Met Pro 
        195                 200                 205             


Asn Gly Ala Thr Val Ser Ala Ser Ser Val Glu His Thr His Gly Glu 
    210                 215                 220                 


Leu Leu Glu Lys Thr Leu Ser Gln Tyr Tyr Pro Asp Cys Val Ser Ile 
225                 230                 235                 240 


Ala Val Gln Lys Thr Thr Ser His Ile Asn Ala Ile Asn Ser Gln Ala 
                245                 250                 255     


Thr Asn Glu Leu Ser Cys Glu Ile Thr His Pro Ser His Thr Ser Gly 
            260                 265                 270         


Gln Ile Asn Ser Ala Gln Thr Ser Asn Ser Glu Leu Pro Pro Lys Pro 
        275                 280                 285             


Ala Ala Val Val Ser Glu Ala Cys Asp Ala Asp Asp Ala Asp Asn Ala 
    290                 295                 300                 


Ser Lys Leu Ala Ala Met Leu Asn Thr Cys Ser Phe Gln Lys Pro Glu 
305                 310                 315                 320 


Gln Leu Gln Gln Gln Lys Ser Val Phe Glu Ile Cys Pro Ser Pro Ala 
                325                 330                 335     


Glu Asn Asn Ile Gln Gly Thr Thr Lys Leu Ala Ser Gly Glu Glu Phe 
            340                 345                 350         


Cys Ser Gly Ser Ser Ser Asn Leu Gln Ala Pro Gly Gly Ser Ser Glu 
        355                 360                 365             


Arg Tyr Leu Lys Gln Asn Glu Met Asn Gly Ala Tyr Phe Lys Gln Ser 
    370                 375                 380                 


Ser Val Phe Thr Lys Asp Ser Phe Ser Ala Thr Thr Thr Pro Pro Pro 
385                 390                 395                 400 


Pro Ser Gln Leu Leu Leu Ser Pro Pro Pro Pro Leu Pro Gln Val Pro 
                405                 410                 415     


Gln Leu Pro Ser Glu Gly Lys Ser Thr Leu Asn Gly Gly Val Leu Glu 
            420                 425                 430         


Glu His His His Tyr Pro Asn Gln Ser Asn Thr Thr Leu Leu Arg Glu 
        435                 440                 445             


Val Lys Ile Glu Gly Lys Pro Glu Ala Pro Pro Ser Gln Ser Pro Asn 
    450                 455                 460                 


Pro Ser Thr His Val Cys Ser Pro Ser Pro Met Leu Ser Glu Arg Pro 
465                 470                 475                 480 


Gln Asn Asn Cys Val Asn Arg Asn Asp Ile Gln Thr Ala Gly Thr Met 
                485                 490                 495     


Thr Val Pro Leu Cys Ser Glu Lys Thr Arg Pro Met Ser Glu His Leu 
            500                 505                 510         


Lys His Asn Pro Pro Ile Phe Gly Ser Ser Gly Glu Leu Gln Asp Asn 
        515                 520                 525             


Cys Gln Gln Leu Met Arg Asn Lys Glu Gln Glu Ile Leu Lys Gly Arg 
    530                 535                 540                 


Asp Lys Glu Gln Thr Arg Asp Leu Val Pro Pro Thr Gln His Tyr Leu 
545                 550                 555                 560 


Lys Pro Gly Trp Ile Glu Leu Lys Ala Pro Arg Phe His Gln Ala Glu 
                565                 570                 575     


Ser His Leu Lys Arg Asn Glu Ala Ser Leu Pro Ser Ile Leu Gln Tyr 
            580                 585                 590         


Gln Pro Asn Leu Ser Asn Gln Met Thr Ser Lys Gln Tyr Thr Gly Asn 
        595                 600                 605             


Ser Asn Met Pro Gly Gly Leu Pro Arg Gln Ala Tyr Thr Gln Lys Thr 
    610                 615                 620                 


Thr Gln Leu Glu His Lys Ser Gln Met Tyr Gln Val Glu Met Asn Gln 
625                 630                 635                 640 


Gly Gln Ser Gln Gly Thr Val Asp Gln His Leu Gln Phe Gln Lys Pro 
                645                 650                 655     


Ser His Gln Val His Phe Ser Lys Thr Asp His Leu Pro Lys Ala His 
            660                 665                 670         


Val Gln Ser Leu Cys Gly Thr Arg Phe His Phe Gln Gln Arg Ala Asp 
        675                 680                 685             


Ser Gln Thr Glu Lys Leu Met Ser Pro Val Leu Lys Gln His Leu Asn 
    690                 695                 700                 


Gln Gln Ala Ser Glu Thr Glu Pro Phe Ser Asn Ser His Leu Leu Gln 
705                 710                 715                 720 


His Lys Pro His Lys Gln Ala Ala Gln Thr Gln Pro Ser Gln Ser Ser 
                725                 730                 735     


His Leu Pro Gln Asn Gln Gln Gln Gln Gln Lys Leu Gln Ile Lys Asn 
            740                 745                 750         


Lys Glu Glu Ile Leu Gln Thr Phe Pro His Pro Gln Ser Asn Asn Asp 
        755                 760                 765             


Gln Gln Arg Glu Gly Ser Phe Phe Gly Gln Thr Lys Val Glu Glu Cys 
    770                 775                 780                 


Phe His Gly Glu Asn Gln Tyr Ser Lys Ser Ser Glu Phe Glu Thr His 
785                 790                 795                 800 


Asn Val Gln Met Gly Leu Glu Glu Val Gln Asn Ile Asn Arg Arg Asn 
                805                 810                 815     


Ser Pro Tyr Ser Gln Thr Met Lys Ser Ser Ala Cys Lys Ile Gln Val 
            820                 825                 830         


Ser Cys Ser Asn Asn Thr His Leu Val Ser Glu Asn Lys Glu Gln Thr 
        835                 840                 845             


Thr His Pro Glu Leu Phe Ala Gly Asn Lys Thr Gln Asn Leu His His 
    850                 855                 860                 


Met Gln Tyr Phe Pro Asn Asn Val Ile Pro Lys Gln Asp Leu Leu His 
865                 870                 875                 880 


Arg Cys Phe Gln Glu Gln Glu Gln Lys Ser Gln Gln Ala Ser Val Leu 
                885                 890                 895     


Gln Gly Tyr Lys Asn Arg Asn Gln Asp Met Ser Gly Gln Gln Ala Ala 
            900                 905                 910         


Gln Leu Ala Gln Gln Arg Tyr Leu Ile His Asn His Ala Asn Val Phe 
        915                 920                 925             


Pro Val Pro Asp Gln Gly Gly Ser His Thr Gln Thr Pro Pro Gln Lys 
    930                 935                 940                 


Asp Thr Gln Lys His Ala Ala Leu Arg Trp His Leu Leu Gln Lys Gln 
945                 950                 955                 960 


Glu Gln Gln Gln Thr Gln Gln Pro Gln Thr Glu Ser Cys His Ser Gln 
                965                 970                 975     


Met His Arg Pro Ile Lys Val Glu Pro Gly Cys Lys Pro His Ala Cys 
            980                 985                 990         


Met His Thr Ala Pro Pro Glu Asn  Lys Thr Trp Lys Lys  Val Thr Lys 
        995                 1000                 1005             


Gln Glu  Asn Pro Pro Ala Ser  Cys Asp Asn Val Gln  Gln Lys Ser 
    1010                 1015                 1020             


Ile Ile  Glu Thr Met Glu Gln  His Leu Lys Gln Phe  His Ala Lys 
    1025                 1030                 1035             


Ser Leu  Phe Asp His Lys Ala  Leu Thr Leu Lys Ser  Gln Lys Gln 
    1040                 1045                 1050             


Val Lys  Val Glu Met Ser Gly  Pro Val Thr Val Leu  Thr Arg Gln 
    1055                 1060                 1065             


Thr Thr  Ala Ala Glu Leu Asp  Ser His Thr Pro Ala  Leu Glu Gln 
    1070                 1075                 1080             


Gln Thr  Thr Ser Ser Glu Lys  Thr Pro Thr Lys Arg  Thr Ala Ala 
    1085                 1090                 1095             


Ser Val  Leu Asn Asn Phe Ile  Glu Ser Pro Ser Lys  Leu Leu Asp 
    1100                 1105                 1110             


Thr Pro  Ile Lys Asn Leu Leu  Asp Thr Pro Val Lys  Thr Gln Tyr 
    1115                 1120                 1125             


Asp Phe  Pro Ser Cys Arg Cys  Val Glu Gln Ile Ile  Glu Lys Asp 
    1130                 1135                 1140             


Glu Gly  Pro Phe Tyr Thr His  Leu Gly Ala Gly Pro  Asn Val Ala 
    1145                 1150                 1155             


Ala Ile  Arg Glu Ile Met Glu  Glu Arg Phe Gly Gln  Lys Gly Lys 
    1160                 1165                 1170             


Ala Ile  Arg Ile Glu Arg Val  Ile Tyr Thr Gly Lys  Glu Gly Lys 
    1175                 1180                 1185             


Ser Ser  Gln Gly Cys Pro Ile  Ala Lys Trp Val Val  Arg Arg Ser 
    1190                 1195                 1200             


Ser Ser  Glu Glu Lys Leu Leu  Cys Leu Val Arg Glu  Arg Ala Gly 
    1205                 1210                 1215             


His Thr  Cys Glu Ala Ala Val  Ile Val Ile Leu Ile  Leu Val Trp 
    1220                 1225                 1230             


Glu Gly  Ile Pro Leu Ser Leu  Ala Asp Lys Leu Tyr  Ser Glu Leu 
    1235                 1240                 1245             


Thr Glu  Thr Leu Arg Lys Tyr  Gly Thr Leu Thr Asn  Arg Arg Cys 
    1250                 1255                 1260             


Ala Leu  Asn Glu Glu Arg Thr  Cys Ala Cys Gln Gly  Leu Asp Pro 
    1265                 1270                 1275             


Glu Thr  Cys Gly Ala Ser Phe  Ser Phe Gly Cys Ser  Trp Ser Met 
    1280                 1285                 1290             


Tyr Tyr  Asn Gly Cys Lys Phe  Ala Arg Ser Lys Ile  Pro Arg Lys 
    1295                 1300                 1305             


Phe Lys  Leu Leu Gly Asp Asp  Pro Lys Glu Glu Glu  Lys Leu Glu 
    1310                 1315                 1320             


Ser His  Leu Gln Asn Leu Ser  Thr Leu Met Ala Pro  Thr Tyr Lys 
    1325                 1330                 1335             


Lys Leu  Ala Pro Asp Ala Tyr  Asn Asn Gln Ile Glu  Tyr Glu His 
    1340                 1345                 1350             


Arg Ala  Pro Glu Cys Arg Leu  Gly Leu Lys Glu Gly  Arg Pro Phe 
    1355                 1360                 1365             


Ser Gly  Val Thr Ala Cys Leu  Asp Phe Cys Ala His  Ala His Arg 
    1370                 1375                 1380             


Asp Leu  His Asn Met Gln Asn  Gly Ser Thr Leu Val  Cys Thr Leu 
    1385                 1390                 1395             


Thr Arg  Glu Asp Asn Arg Glu  Phe Gly Gly Lys Pro  Glu Asp Glu 
    1400                 1405                 1410             


Gln Leu  His Val Leu Pro Leu  Tyr Lys Val Ser Asp  Val Asp Glu 
    1415                 1420                 1425             


Phe Gly  Ser Val Glu Ala Gln  Glu Glu Lys Lys Arg  Ser Gly Ala 
    1430                 1435                 1440             


Ile Gln  Val Leu Ser Ser Phe  Arg Arg Lys Val Arg  Met Leu Ala 
    1445                 1450                 1455             


Glu Pro  Val Lys Thr Cys Arg  Gln Arg Lys Leu Glu  Ala Lys Lys 
    1460                 1465                 1470             


Ala Ala  Ala Glu Lys Leu Ser  Ser Leu Glu Asn Ser  Ser Asn Lys 
    1475                 1480                 1485             


Asn Glu  Lys Glu Lys Ser Ala  Pro Ser Arg Thr Lys  Gln Thr Glu 
    1490                 1495                 1500             


Asn Ala  Ser Gln Ala Lys Gln  Leu Ala Glu Leu Leu  Arg Leu Ser 
    1505                 1510                 1515             


Gly Pro  Val Met Gln Gln Ser  Gln Gln Pro Gln Pro  Leu Gln Lys 
    1520                 1525                 1530             


Gln Pro  Pro Gln Pro Gln Gln  Gln Gln Arg Pro Gln  Gln Gln Gln 
    1535                 1540                 1545             


Pro His  His Pro Gln Thr Glu  Ser Val Asn Ser Tyr  Ser Ala Ser 
    1550                 1555                 1560             


Gly Ser  Thr Asn Pro Tyr Met  Arg Arg Pro Asn Pro  Val Ser Pro 
    1565                 1570                 1575             


Tyr Pro  Asn Ser Ser His Thr  Ser Asp Ile Tyr Gly  Ser Thr Ser 
    1580                 1585                 1590             


Pro Met  Asn Phe Tyr Ser Thr  Ser Ser Gln Ala Ala  Gly Ser Tyr 
    1595                 1600                 1605             


Leu Asn  Ser Ser Asn Pro Met  Asn Pro Tyr Pro Gly  Leu Leu Asn 
    1610                 1615                 1620             


Gln Asn  Thr Gln Tyr Pro Ser  Tyr Gln Cys Asn Gly  Asn Leu Ser 
    1625                 1630                 1635             


Val Asp  Asn Cys Ser Pro Tyr  Leu Gly Ser Tyr Ser  Pro Gln Ser 
    1640                 1645                 1650             


Gln Pro  Met Asp Leu Tyr Arg  Tyr Pro Ser Gln Asp  Pro Leu Ser 
    1655                 1660                 1665             


Lys Leu  Ser Leu Pro Pro Ile  His Thr Leu Tyr Gln  Pro Arg Phe 
    1670                 1675                 1680             


Gly Asn  Ser Gln Ser Phe Thr  Ser Lys Tyr Leu Gly  Tyr Gly Asn 
    1685                 1690                 1695             


Gln Asn  Met Gln Gly Asp Gly  Phe Ser Ser Cys Thr  Ile Arg Pro 
    1700                 1705                 1710             


Asn Val  His His Val Gly Lys  Leu Pro Pro Tyr Pro  Thr His Glu 
    1715                 1720                 1725             


Met Asp  Gly His Phe Met Gly  Ala Thr Ser Arg Leu  Pro Pro Asn 
    1730                 1735                 1740             


Leu Ser  Asn Pro Asn Met Asp  Tyr Lys Asn Gly Glu  His His Ser 
    1745                 1750                 1755             


Pro Ser  His Ile Ile His Asn  Tyr Ser Ala Ala Pro  Gly Met Phe 
    1760                 1765                 1770             


Asn Ser  Ser Leu His Ala Leu  His Leu Gln Asn Lys  Glu Asn Asp 
    1775                 1780                 1785             


Met Leu  Ser His Thr Ala Asn  Gly Leu Ser Lys Met  Leu Pro Ala 
    1790                 1795                 1800             


Leu Asn  His Asp Arg Thr Ala  Cys Val Gln Gly Gly  Leu His Lys 
    1805                 1810                 1815             


Leu Ser  Asp Ala Asn Gly Gln  Glu Lys Gln Pro Leu  Ala Leu Val 
    1820                 1825                 1830             


Gln Gly  Val Ala Ser Gly Ala  Glu Asp Asn Asp Glu  Val Trp Ser 
    1835                 1840                 1845             


Asp Ser  Glu Gln Ser Phe Leu  Asp Pro Asp Ile Gly  Gly Val Ala 
    1850                 1855                 1860             


Val Ala  Pro Thr His Gly Ser  Ile Leu Ile Glu Cys  Ala Lys Arg 
    1865                 1870                 1875             


Glu Leu  His Ala Thr Thr Pro  Leu Lys Asn Pro Asn  Arg Asn His 
    1880                 1885                 1890             


Pro Thr  Arg Ile Ser Leu Val  Phe Tyr Gln His Lys  Ser Met Asn 
    1895                 1900                 1905             


Glu Pro  Lys His Gly Leu Ala  Leu Trp Glu Ala Lys  Met Ala Glu 
    1910                 1915                 1920             


Lys Ala  Arg Glu Lys Glu Glu  Glu Cys Glu Lys Tyr  Gly Pro Asp 
    1925                 1930                 1935             


Tyr Val  Pro Gln Lys Ser His  Gly Lys Lys Val Lys  Arg Glu Pro 
    1940                 1945                 1950             


Ala Glu  Pro His Glu Thr Ser  Glu Pro Thr Tyr Leu  Arg Phe Ile 
    1955                 1960                 1965             


Lys Ser  Leu Ala Glu Arg Thr  Met Ser Val Thr Thr  Asp Ser Thr 
    1970                 1975                 1980             


Val Thr  Thr Ser Pro Tyr Ala  Phe Thr Arg Val Thr  Gly Pro Tyr 
    1985                 1990                 1995             


Asn Arg  Tyr Ile 
    2000         


<210>  3
<211>  7274
<212>  DNA
<213>  Homo sapiens

<400>  3
catagagcca gcgggcgcgg gcgggacggg cgccccgcgg ccggacccag ccagggcacc       60

acgctgcccg gccctgcgcc gccaggcact tctttccggg gctcctaggg acgccagaag      120

gaagtcaacc tctgctgctt ctccttggcc tgcgttggac cttccttttt ttgttgtttt      180

tttttgtttt tcccctttct tccttttgaa ttaactggct tcttggctgg atgttttcaa      240

cttctttcct ggctgcgaac ttttccccaa ttgttttcct tttacaacag ggggagaaag      300

tgctctgtgg tccgaggcga gccgtgaagt tgcgtgtgcg tggcagtgtg cgtggcagga      360

tgtgcgtgcg tgtgtaaccc gagccgcccg atctgtttcg atctgcgccg cggagccctc      420

cctcaaggcc cgctccacct gctgcggtta cgcggcgctc gtgggtgttc gtgcctcgga      480

gcagctaacc ggcgggtgct gggcgacggt ggaggagtat cgtctcgctg ctgcccgagt      540

cagggctgag tcacccagct gatgtagaca gtggctgcct tccgaagagt gcgtgtttgc      600

atgtgtgtga ctctgcggct gctcaactcc caacaaacca gaggaccagc cacaaactta      660

accaacatcc ccaaacccga gttcacagat gtgggagagc tgtagaaccc tgagtgtcat      720

cgactgggcc ttcttatgat tgttgtttta agattagctg aagatctctg aaacgctgaa      780

ttttctgcac tgagcgtttt gacagaattc attgagagaa cagagaacat gacaagtact      840

tctagctcag cactgctcca actactgaag ctgattttca aggctactta aaaaaatctg      900

cagcgtacat taatggattt ctgttgtgtt taaattctcc acagattgta ttgtaaatat      960

tttatgaagt agagcatatg tatatattta tatatacgtg cacatacatt agtagcacta     1020

cctttggaag tctcagctct tgcttttcgg gactgaagcc agttttgcat gataaaagtg     1080

gccttgttac gggagataat tgtgttctgt tgggacttta gacaaaactc acctgcaaaa     1140

aactgacagg cattaactac tggaacttcc aaataatgtg tttgctgatc gttttactct     1200

tcgcataaat attttaggaa gtgtatgaga attttgcctt caggaacttt tctaacagcc     1260

aaagacagaa cttaacctct gcaagcaaga ttcgtggaag atagtctcca ctttttaatg     1320

cactaagcaa tcggttgcta ggagcccatc ctgggtcaga ggccgatccg cagaaccaga     1380

acgttttccc ctcctggact gttagtaact tagtctccct cctcccctaa ccacccccgc     1440

ccccccccac cccccgcagt aataaaggcc cctgaacgtg tatgttggtc tcccgggagc     1500

tgcttgctga agatccgcgc ccctgtcgcc gtctggtagg agctgtttgc agggtcctaa     1560

ctcaatcggc ttgttgtgat gcgtatcccc gtagatgcca gcacgagccg ccgcttcacg     1620

ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct gggcgccccg     1680

gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat ggtggaggtg     1740

ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct ctgctccgtg     1800

ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt ggtggcccta     1860

ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga aaactactcg     1920

gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt taatgacctc     1980

aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac tgtcttcaca     2040

aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga tgggccccga     2100

gaacctcgaa gacatcggca gaaactagat gatcagacca agcccgggag cttgtccttt     2160

tccgagcggc tcagtgaact ggagcagctg cggcgcacag ccatgagggt cagcccacac     2220

cacccagccc ccacgcccaa ccctcgtgcc tccctgaacc actccactgc ctttaaccct     2280

cagcctcaga gtcagatgca ggatacaagg cagatccaac catccccacc gtggtcctac     2340

gatcagtcct accaatacct gggatccatt gcctctcctt ctgtgcaccc agcaacgccc     2400

atttcacctg gacgtgccag cggcatgaca accctctctg cagaactttc cagtcgactc     2460

tcaacggcac ccgacctgac agcgttcagc gacccgcgcc agttccccgc gctgccctcc     2520

atctccgacc cccgcatgca ctatccaggc gccttcacct actccccgac gccggtcacc     2580

tcgggcatcg gcatcggcat gtcggccatg ggctcggcca cgcgctacca cacctacctg     2640

ccgccgccct accccggctc gtcgcaagcg cagggaggcc cgttccaagc cagctcgccc     2700

tcctaccacc tgtactacgg cgcctcggcc ggctcctacc agttctccat ggtgggcggc     2760

gagcgctcgc cgccgcgcat cctgccgccc tgcaccaacg cctccaccgg ctccgcgctg     2820

ctcaacccca gcctcccgaa ccagagcgac gtggtggagg ccgagggcag ccacagcaac     2880

tcccccacca acatggcgcc ctccgcgcgc ctggaggagg ccgtgtggag gccctactga     2940

ggcgccaggc ctggcccggc tgggccccgc gggccgccgc cttcgcctcc gggcgcgcgg     3000

gcctcctgtt cgcgacaagc ccgccgggat cccgggccct gggcccggcc accgtcctgg     3060

ggccgagggc gcccgacggc caggatctcg ctgtaggtca ggcccgcgca gcctcctgcg     3120

cccagaagcc cacgccgccg ccgtctgctg gcgccccggc cctcgcggag gtgtccgagg     3180

cgacgcacct cgagggtgtc cgccggcccc agcacccagg ggacgcgctg gaaagcaaac     3240

aggaagattc ccggagggaa actgtgaatg cttctgattt agcaatgctg tgaataaaaa     3300

gaaagatttt atacccttga cttaactttt taaccaagtt gtttattcca aagagtgtgg     3360

aattttggtt ggggtggggg gagaggaggg atgcaactcg ccctgtttgg catctaattc     3420

ttatttttaa tttttccgca ccttatcaat tgcaaaatgc gtatttgcat ttgggtggtt     3480

tttattttta tatacgttta tataaatata tataaattga gcttgcttct ttcttgcttt     3540

gaccatggaa agaaatatga ttcccttttc tttaagtttt atttaacttt tcttttggac     3600

ttttgggtag ttgttttttt ttgttttgtt ttgttttttt gagaaacagc tacagctttg     3660

ggtcattttt aactactgta ttcccacaag gaatccccag atatttatgt atcttgatgt     3720

tcagacattt atgtgttgat aattttttaa ttatttaaat gtacttatat taagaaaaat     3780

atcaagtact acattttctt ttgttcttga tagtagccaa agttaaatgt atcacattga     3840

agaaggctag aaaaaaagaa tgagtaatgt gatcgcttgg ttatccagaa gtattgttta     3900

cattaaactc cctttcatgt taatcaaaca agtgagtagc tcacgcagca acgtttttaa     3960

taggattttt agacactgag ggtcactcca aggatcagaa gtatggaatt ttctgccagg     4020

ctcaacaagg gtctcatatc taacttcctc cttaaaacag agaaggtcaa tctagttcca     4080

gagggttgag gcaggtgcca ataattacat ctttggagag gatttgattt ctgcccaggg     4140

atttgctcac cccaaggtca tctgataatt tcacagatgc tgtgtaacag aacacagcca     4200

aagtaaactg tgtaggggag ccacatttac ataggaacca aatcaatgaa tttaggggtt     4260

acgattatag caatttaagg gcccaccaga agcaggcctc gaggagtcaa tttgcctctg     4320

tgtgcctcag tggagacaag tgggaaaaca tggtcccacc tgtgcgagac cccctgtcct     4380

gtgctgctca ctcaacaaca tctttgtgtt gctttcacca ggctgagacc ctaccctatg     4440

gggtatatgg gcttttacct gtgcaccagt gtgacaggaa agattcatgt cactactgtc     4500

cgtggctaca attcaaaggt atccaatgtc gctgtaaatt ttatggcact atttttattg     4560

gaggatttgg tcagaatgca gttgttgtac aactcataaa tactaactgc tgattttgac     4620

acatgtgtgc tccaaatgat ctggtggtta tttaacgtac ctcttaaaat tcgttgaaac     4680

gatttcaggt caactctgaa gagtatttga aagcaggact tcagaacagt gtttgatttt     4740

tattttataa atttaagcat tcaaattagg caaatctttg gctgcaggca gcaaaaacag     4800

ctggacttat ttaaaacaac ttgtttttga gttttcttat atatatattg attatttgtt     4860

ttacacacat gcagtagcac tttggtaaga gttaaagagt aaagcagctt atgttgtcag     4920

gtcgttctta tctagagaag agctatagca gatctcggac aaactcagaa tatattcact     4980

ttcatttttg acaggattcc ctccacaact cagtttcata tattattccg tattacattt     5040

ttgcagctaa attaccataa aatgtcagca aatgtaaaaa tttaatttct gaaaagcacc     5100

attagcccat ttcccccaaa ttaaacgtaa atgttttttt tcagcacatg ttaccatgtc     5160

tgacctgcaa aaatgctgga gaaaaatgaa ggaaaaaatt atgtttttca gtttaattct     5220

gttaactgaa gatattccaa ctcaaaacca gcctcatgct ctgattagat aatcttttac     5280

attgaacctt tactctcaaa gccatgtgtg gagggggctt gtcactattg taggctcact     5340

ggattggtca tttagagttt cacagactct taccagcata tatagtattt aattgtttca     5400

aaaaaaatca aactgtagtt gttttggcga taggtctcac gcaacacatt tttgtatgtg     5460

tgtgtgtgtg cgtgtgtgtg tgtgtgtgtg aaaaattgca ttcattgact tcaggtagat     5520

taaggtatct ttttattcat tgccctcagg aaagttaagg tatcaatgag acccttaagc     5580

caatcatgta ataactgcat gtgtctggtc caggagaagt attgaataag ccatttctac     5640

tgcttactca tgtccctatt tatgatttca acatggatac atatttcagt tctttctttt     5700

tctcactatc tgaaaataca tttccctccc tctcttcccc ccaatatctc cctttttttc     5760

tctcttcctc tatcttccaa accccacttt ctccctcctc cttttcctgt gttctcttaa     5820

gcagatagca cataccccca cccagtacca aatttcagaa cacaagaagg tccagttctt     5880

cccccttcac ataaaggaac atggtttgtc agcctttctc ctgtttatgg gtttcttcca     5940

gcagaacaga gacattgcca accatattgg atctgcttgc tgtccaaacc agcaaacttt     6000

cctgggcaaa tcacaatcag tgagtaaata gacagccttt ctgctgcctt gggtttctgt     6060

gcagataaac agaaatgctc tgattagaaa ggaaatgaat ggttccactc aaatgtcctg     6120

caatttagga ttgcagattt ctgccttgaa atacctgttt ctttgggaca ttccgtcctg     6180

atgattttta tttttgttgg tttttatttt tggggggaat gacatgtttg ggtcttttat     6240

acatgaaaat ttgtttgaca ataatctcac aaaacatatt ttacatctga acaaaatgcc     6300

tttttgttta ccgtagcgta tacatttgtt ttgggatttt tgtgtgtttg ttgggaattt     6360

tgtttttagc caggtcagta ttgatgaggc tgatcatttg gctctttttt tccttccaga     6420

agagttgcat caacaaagtt aattgtattt atgtatgtaa atagatttta agcttcatta     6480

taaaatattg ttaatgccta taactttttt tcaatttttt tgtgtgtgtt tctaaggact     6540

ttttcttagg tttgctaaat actgtaggga aaaaaatgct tctttctact ttgtttattt     6600

tagactttaa aatgagctac ttcttattca cttttgtaaa cagctaatag catggttcca     6660

atttttttta agttcacttt ttttgttcta ggggaaatga atgtgcaaaa aaagaaaaag     6720

aactgttggt tatttgtgtt attctggatg tataaaaatc aatggaaaaa aataaacttt     6780

caaattgaaa tgacggtata acacatctac tgaaaaagca acgggaaatg tggtcctatt     6840

taagccagcc cccacctagg gtctatttgt gtggcagtta ttgggtttgg tcacaaaaca     6900

tcctgaaaat tcgtgcgtgg gcttctttct ccctggtaca aacgtatgga atgcttctta     6960

aaggggaact gtcaagctgg tgtcttcagc cagatgacat gagagaatat cccagaaccc     7020

tctctccaag gtgtttctag atagcacagg agagcaggca ctgcactgtc cacagtccac     7080

ggtacacagt cgggtgggcc gcctcccctc tcctgggagc attcgtcgtg cccagcctga     7140

gcagggcagc tggactgctg ctgttcagga gccaccagag ccttcctctc tttgtaccac     7200

agtttcttct gtaaatccag tgttacaatc agtgtgaatg gcaaataaac agtttgacaa     7260

gtacatacac cata                                                       7274


<210>  4
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                325                 330                 335     


Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
            340                 345                 350         


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
        355                 360                 365             


Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
    370                 375                 380                 


Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
385                 390                 395                 400 


Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn 
                405                 410                 415     


Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
            420                 425                 430         


Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala 
        435                 440                 445             


Val Trp Arg Pro Tyr 
    450             


<210>  5
<211>  4454
<212>  DNA
<213>  Homo sapiens

<400>  5
gaaacgtccc gtgtgggagg ggcgggtctg ggtgcggcct gccgcatgac tcgtggttcg       60

gaggcccacg tggccggggc ggggactcag gcgcctgggg cgccgactga ttacgtagcg      120

ggcggggccg gaagtgccgc tccttggtgg gggctgttca tggcggttcc ggggtctcca      180

acatttttcc cggctgtggt cctaaatctg tccaaagcag aggcagtgga gcttgaggtt      240

cttgctggtg tgaaatgact gagtacaaac tggtggtggt tggagcaggt ggtgttggga      300

aaagcgcact gacaatccag ctaatccaga accactttgt agatgaatat gatcccacca      360

tagaggattc ttacagaaaa caagtggtta tagatggtga aacctgtttg ttggacatac      420

tggatacagc tggacaagaa gagtacagtg ccatgagaga ccaatacatg aggacaggcg      480

aaggcttcct ctgtgtattt gccatcaata atagcaagtc atttgcggat attaacctct      540

acagggagca gattaagcga gtaaaagact cggatgatgt acctatggtg ctagtgggaa      600

acaagtgtga tttgccaaca aggacagttg atacaaaaca agcccacgaa ctggccaaga      660

gttacgggat tccattcatt gaaacctcag ccaagaccag acagggtgtt gaagatgctt      720

tttacacact ggtaagagaa atacgccagt accgaatgaa aaaactcaac agcagtgatg      780

atgggactca gggttgtatg ggattgccat gtgtggtgat gtaacaagat acttttaaag      840

ttttgtcaga aaagagccac tttcaagctg cactgacacc ctggtcctga cttccctgga      900

ggagaagtat tcctgttgct gtcttcagtc tcacagagaa gctcctgcta cttccccagc      960

tctcagtagt ttagtacaat aatctctatt tgagaagttc tcagaataac tacctcctca     1020

cttggctgtc tgaccagaga atgcacctct tgttactccc tgttattttt ctgccctggg     1080

ttcttccaca gcacaaacac acctctgcca ccccaggttt ttcatctgaa aagcagttca     1140

tgtctgaaac agagaaccaa accgcaaacg tgaaattcta ttgaaaacag tgtcttgagc     1200

tctaaagtag caactgctgg tgattttttt tttcttttta ctgttgaact tagaactatg     1260

ctaatttttg gagaaatgtc ataaattact gttttgccaa gaatatagtt attattgctg     1320

tttggtttgt ttataatgtt atcggctcta ttctctaaac tggcatctgc tctagattca     1380

taaatacaaa aatgaatact gaattttgag tctatcctag tcttcacaac tttgacgtaa     1440

ttaaatccaa ctttcacagt gaagtgcctt tttcctagaa gtggtttgta gacttccttt     1500

ataatatttc agtggaatag atgtctcaaa aatccttatg catgaaatga atgtctgaga     1560

tacgtctgtg acttatctac cattgaagga aagctatatc tatttgagag cagatgccat     1620

tttgtacatg tatgaaattg gttttccaga ggcctgtttt ggggctttcc caggagaaag     1680

atgaaactga aagcacatga ataatttcac ttaataattt ttacctaatc tccacttttt     1740

tcataggtta ctacctatac aatgtatgta atttgtttcc cctagcttac tgataaacct     1800

aatattcaat gaacttccat ttgtattcaa atttgtgtca taccagaaag ctctacattt     1860

gcagatgttc aaatattgta aaactttggt gcattgttat ttaatagctg tgatcagtga     1920

ttttcaaacc tcaaatatag tatattaaca aattacattt tcactgtata tcatggtatc     1980

ttaatgatgt atataattgc cttcaatccc cttctcaccc caccctctac agcttccccc     2040

acagcaatag gggcttgatt atttcagttg agtaaagcat ggtgctaatg gaccagggtc     2100

acagtttcaa aacttgaaca atccagttag catcacagag aaagaaattc ttctgcattt     2160

gctcattgca ccagtaactc cagctagtaa ttttgctagg tagctgcagt tagccctgca     2220

aggaaagaag aggtcagtta gcacaaaccc tttaccatga ctggaaaact cagtatcacg     2280

tatttaaaca tttttttttc ttttagccat gtagaaactc taaattaagc caatattctc     2340

atttgagaat gaggatgtct cagctgagaa acgttttaaa ttctctttat tcataatgtt     2400

ctttgaaggg tttaaaacaa gatgttgata aatctaagct gatgagtttg ctcaaaacag     2460

gaagttgaaa ttgttgagac aggaatggaa aatataatta attgatacct atgaggattt     2520

ggaggcttgg cattttaatt tgcagataat accctggtaa ttctcatgaa aaatagactt     2580

ggataacttt tgataaaaga ctaattccaa aatggccact ttgttcctgt ctttaatatc     2640

taaatactta ctgaggtcct ccatcttcta tattatgaat tttcatttat taagcaaatg     2700

tcatattacc ttgaaattca gaagagaaga aacatatact gtgtccagag tataatgaac     2760

ctgcagagtt gtgcttctta ctgctaattc tgggagcttt cacagtactg tcatcatttg     2820

taaatggaaa ttctgctttt ctgtttctgc tccttctgga gcagtgctac tctgtaattt     2880

tcctgaggct tatcacctca gtcatttctt ttttaaatgt ctgtgactgg cagtgattct     2940

ttttcttaaa aatctattaa atttgatgtc aaattaggga gaaagatagt tactcatctt     3000

gggctcttgt gccaatagcc cttgtatgta tgtacttaga gttttccaag tatgttctaa     3060

gcacagaagt ttctaaatgg ggccaaaatt cagacttgag tatgttcttt gaatacctta     3120

agaagttaca attagccggg catggtggcc cgtgcctgta gtcccagcta cttgagaggc     3180

tgaggcagga gaatcacttc aacccaggag gtggaggtta cagtgagcag agatcgtgcc     3240

actgcactcc agcctgggtg acaagagaga cttgtctcca aaaaaaaagt tacacctagg     3300

tgtgaatttt ggcacaaagg agtgacaaac ttatagttaa aagctgaata acttcagtgt     3360

ggtataaaac gtggttttta ggctatgttt gtgattgctg aaaagaattc tagtttacct     3420

caaaatcctt ctctttcccc aaattaagtg cctggccagc tgtcataaat tacatattcc     3480

ttttggtttt tttaaaggtt acatgttcaa gagtgaaaat aagatgttct gtctgaaggc     3540

taccatgccg gatctgtaaa tgaacctgtt aaatgctgta tttgctccaa cggcttacta     3600

tagaatgtta cttaatacaa tatcatactt attacaattt ttactatagg agtgtaatag     3660

gtaaaattaa tctctatttt agtgggccca tgtttagtct ttcaccatcc tttaaactgc     3720

tgtgaatttt tttgtcatga cttgaaagca aggatagaga aacactttag agatatgtgg     3780

ggttttttta ccattccaga gcttgtgagc ataatcatat ttgctttata tttatagtca     3840

tgaactccta agttggcagc tacaaccaag aaccaaaaaa tggtgcgttc tgcttcttgt     3900

aattcatctc tgctaataaa ttataagaag caaggaaaat tagggaaaat attttatttg     3960

gatggtttct ataaacaagg gactataatt cttgtacatt atttttcatc tttgctgttt     4020

ctttgagcag tctaatgtgc cacacaatta tctaaggtat ttgttttcta taagaattgt     4080

tttaaaagta ttcttgttac cagagtagtt gtattatatt tcaaaacgta agatgatttt     4140

taaaagcctg agtactgacc taagatggaa ttgtatgaac tctgctctgg agggagggga     4200

ggatgtccgt ggaagttgta agacttttat ttttttgtgc catcaaatat aggtaaaaat     4260

aattgtgcaa ttctgctgtt taaacaggaa ctattggcct ccttggccct aaatggaagg     4320

gccgatattt taagttgatt attttattgt aaattaatcc aacctagttc tttttaattt     4380

ggttgaatgt tttttcttgt taaatgatgt ttaaaaaata aaaactggaa gttcttggct     4440

tagtcataat tctt                                                       4454


<210>  6
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  7
<211>  5765
<212>  DNA
<213>  Homo sapiens

<400>  7
tcctaggcgg cggccgcggc ggcggaggca gcagcggcgg cggcagtggc ggcggcgaag       60

gtggcggcgg ctcggccagt actcccggcc cccgccattt cggactggga gcgagcgcgg      120

cgcaggcact gaaggcggcg gcggggccag aggctcagcg gctcccaggt gcgggagaga      180

ggcctgctga aaatgactga atataaactt gtggtagttg gagctggtgg cgtaggcaag      240

agtgccttga cgatacagct aattcagaat cattttgtgg acgaatatga tccaacaata      300

gaggattcct acaggaagca agtagtaatt gatggagaaa cctgtctctt ggatattctc      360

gacacagcag gtcaagagga gtacagtgca atgagggacc agtacatgag gactggggag      420

ggctttcttt gtgtatttgc cataaataat actaaatcat ttgaagatat tcaccattat      480

agagaacaaa ttaaaagagt taaggactct gaagatgtac ctatggtcct agtaggaaat      540

aaatgtgatt tgccttctag aacagtagac acaaaacagg ctcaggactt agcaagaagt      600

tatggaattc cttttattga aacatcagca aagacaagac agggtgttga tgatgccttc      660

tatacattag ttcgagaaat tcgaaaacat aaagaaaaga tgagcaaaga tggtaaaaag      720

aagaaaaaga agtcaaagac aaagtgtgta attatgtaaa tacaatttgt acttttttct      780

taaggcatac tagtacaagt ggtaattttt gtacattaca ctaaattatt agcatttgtt      840

ttagcattac ctaatttttt tcctgctcca tgcagactgt tagcttttac cttaaatgct      900

tattttaaaa tgacagtgga agtttttttt tcctctaagt gccagtattc ccagagtttt      960

ggtttttgaa ctagcaatgc ctgtgaaaaa gaaactgaat acctaagatt tctgtcttgg     1020

ggtttttggt gcatgcagtt gattacttct tatttttctt accaattgtg aatgttggtg     1080

tgaaacaaat taatgaagct tttgaatcat ccctattctg tgttttatct agtcacataa     1140

atggattaat tactaatttc agttgagacc ttctaattgg tttttactga aacattgagg     1200

gaacacaaat ttatgggctt cctgatgatg attcttctag gcatcatgtc ctatagtttg     1260

tcatccctga tgaatgtaaa gttacactgt tcacaaaggt tttgtctcct ttccactgct     1320

attagtcatg gtcactctcc ccaaaatatt atattttttc tataaaaaga aaaaaatgga     1380

aaaaaattac aaggcaatgg aaactattat aaggccattt ccttttcaca ttagataaat     1440

tactataaag actcctaata gcttttcctg ttaaggcaga cccagtatga aatggggatt     1500

attatagcaa ccattttggg gctatattta catgctacta aatttttata ataattgaaa     1560

agattttaac aagtataaaa aattctcata ggaattaaat gtagtctccc tgtgtcagac     1620

tgctctttca tagtataact ttaaatcttt tcttcaactt gagtctttga agatagtttt     1680

aattctgctt gtgacattaa aagattattt gggccagtta tagcttatta ggtgttgaag     1740

agaccaaggt tgcaaggcca ggccctgtgt gaacctttga gctttcatag agagtttcac     1800

agcatggact gtgtccccac ggtcatccag tgttgtcatg cattggttag tcaaaatggg     1860

gagggactag ggcagtttgg atagctcaac aagatacaat ctcactctgt ggtggtcctg     1920

ctgacaaatc aagagcattg cttttgtttc ttaagaaaac aaactctttt ttaaaaatta     1980

cttttaaata ttaactcaaa agttgagatt ttggggtggt ggtgtgccaa gacattaatt     2040

ttttttttaa acaatgaagt gaaaaagttt tacaatctct aggtttggct agttctctta     2100

acactggtta aattaacatt gcataaacac ttttcaagtc tgatccatat ttaataatgc     2160

tttaaaataa aaataaaaac aatccttttg ataaatttaa aatgttactt attttaaaat     2220

aaatgaagtg agatggcatg gtgaggtgaa agtatcactg gactaggaag aaggtgactt     2280

aggttctaga taggtgtctt ttaggactct gattttgagg acatcactta ctatccattt     2340

cttcatgtta aaagaagtca tctcaaactc ttagtttttt ttttttacaa ctatgtaatt     2400

tatattccat ttacataagg atacacttat ttgtcaagct cagcacaatc tgtaaatttt     2460

taacctatgt tacaccatct tcagtgccag tcttgggcaa aattgtgcaa gaggtgaagt     2520

ttatatttga atatccattc tcgttttagg actcttcttc catattagtg tcatcttgcc     2580

tccctacctt ccacatgccc catgacttga tgcagtttta atacttgtaa ttcccctaac     2640

cataagattt actgctgctg tggatatctc catgaagttt tcccactgag tcacatcaga     2700

aatgccctac atcttatttc ctcagggctc aagagaatct gacagatacc ataaagggat     2760

ttgacctaat cactaatttt caggtggtgg ctgatgcttt gaacatctct ttgctgccca     2820

atccattagc gacagtagga tttttcaaac ctggtatgaa tagacagaac cctatccagt     2880

ggaaggagaa tttaataaag atagtgctga aagaattcct taggtaatct ataactagga     2940

ctactcctgg taacagtaat acattccatt gttttagtaa ccagaaatct tcatgcaatg     3000

aaaaatactt taattcatga agcttacttt ttttttttgg tgtcagagtc tcgctcttgt     3060

cacccaggct ggaatgcagt ggcgccatct cagctcactg caacctccat ctcccaggtt     3120

caagcgattc tcgtgcctcg gcctcctgag tagctgggat tacaggcgtg tgccactaca     3180

ctcaactaat ttttgtattt ttaggagaga cggggtttca ccctgttggc caggctggtc     3240

tcgaactcct gacctcaagt gattcaccca ccttggcctc ataaacctgt tttgcagaac     3300

tcatttattc agcaaatatt tattgagtgc ctaccagatg ccagtcaccg cacaaggcac     3360

tgggtatatg gtatccccaa acaagagaca taatcccggt ccttaggtag tgctagtgtg     3420

gtctgtaata tcttactaag gcctttggta tacgacccag agataacacg atgcgtattt     3480

tagttttgca aagaaggggt ttggtctctg tgccagctct ataattgttt tgctacgatt     3540

ccactgaaac tcttcgatca agctacttta tgtaaatcac ttcattgttt taaaggaata     3600

aacttgatta tattgttttt ttatttggca taactgtgat tcttttagga caattactgt     3660

acacattaag gtgtatgtca gatattcata ttgacccaaa tgtgtaatat tccagttttc     3720

tctgcataag taattaaaat atacttaaaa attaatagtt ttatctgggt acaaataaac     3780

aggtgcctga actagttcac agacaaggaa acttctatgt aaaaatcact atgatttctg     3840

aattgctatg tgaaactaca gatctttgga acactgttta ggtagggtgt taagacttac     3900

acagtacctc gtttctacac agagaaagaa atggccatac ttcaggaact gcagtgctta     3960

tgaggggata tttaggcctc ttgaattttt gatgtagatg ggcatttttt taaggtagtg     4020

gttaattacc tttatgtgaa ctttgaatgg tttaacaaaa gatttgtttt tgtagagatt     4080

ttaaaggggg agaattctag aaataaatgt tacctaatta ttacagcctt aaagacaaaa     4140

atccttgttg aagttttttt aaaaaaagct aaattacata gacttaggca ttaacatgtt     4200

tgtggaagaa tatagcagac gtatattgta tcatttgagt gaatgttccc aagtaggcat     4260

tctaggctct atttaactga gtcacactgc ataggaattt agaacctaac ttttataggt     4320

tatcaaaact gttgtcacca ttgcacaatt ttgtcctaat atatacatag aaactttgtg     4380

gggcatgtta agttacagtt tgcacaagtt catctcattt gtattccatt gatttttttt     4440

ttcttctaaa cattttttct tcaaacagta tataactttt tttaggggat ttttttttag     4500

acagcaaaaa ctatctgaag atttccattt gtcaaaaagt aatgatttct tgataattgt     4560

gtagtaatgt tttttagaac ccagcagtta ccttaaagct gaatttatat ttagtaactt     4620

ctgtgttaat actggatagc atgaattctg cattgagaaa ctgaatagct gtcataaaat     4680

gaaactttct ttctaaagaa agatactcac atgagttctt gaagaatagt cataactaga     4740

ttaagatctg tgttttagtt taatagtttg aagtgcctgt ttgggataat gataggtaat     4800

ttagatgaat ttaggggaaa aaaaagttat ctgcagatat gttgagggcc catctctccc     4860

cccacacccc cacagagcta actgggttac agtgttttat ccgaaagttt ccaattccac     4920

tgtcttgtgt tttcatgttg aaaatacttt tgcatttttc ctttgagtgc caatttctta     4980

ctagtactat ttcttaatgt aacatgttta cctggaatgt attttaacta tttttgtata     5040

gtgtaaactg aaacatgcac attttgtaca ttgtgctttc ttttgtggga catatgcagt     5100

gtgatccagt tgttttccat catttggttg cgctgaccta ggaatgttgg tcatatcaaa     5160

cattaaaaat gaccactctt ttaattgaaa ttaactttta aatgtttata ggagtatgtg     5220

ctgtgaagtg atctaaaatt tgtaatattt ttgtcatgaa ctgtactact cctaattatt     5280

gtaatgtaat aaaaatagtt acagtgacta tgagtgtgta tttattcatg aaatttgaac     5340

tgtttgcccc gaaatggata tggaatactt tataagccat agacactata gtataccagt     5400

gaatctttta tgcagcttgt tagaagtatc ctttatttct aaaaggtgct gtggatatta     5460

tgtaaaggcg tgtttgctta aacttaaaac catatttaga agtagatgca aaacaaatct     5520

gcctttatga caaaaaaata ggataacatt atttatttat ttccttttat caaagaaggt     5580

aattgataca caacaggtga cttggtttta ggcccaaagg tagcagcagc aacattaata     5640

atggaaataa ttgaatagtt agttatgtat gttaatgcca gtcaccagca ggctatttca     5700

aggtcagaag taatgactcc atacatatta tttatttcta taactacatt taaatcatta     5760

ccagg                                                                 5765


<210>  8
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  9
<211>  4395
<212>  DNA
<213>  Homo sapiens

<400>  9
gcagtgggct ctggcggagg tcgggagaac tgcagggcga aggccgccgg gggctccgcg       60

ggctgcgggg ggaggcactt gacaccggcc cggggagagg aggggccgct gtccctgcgg      120

ccagtgctgg atgcggggac ccagcgcaga agcagcgcca ggtggagcca tcgaagcccc      180

cacccacagg ctgacagagg caccgttcac cagagggctc aacaccggga tctatgttta      240

agttttaact ctcgcctcca aagaccacga taattccttc cccaaagccc agcagccccc      300

cagccccgcg cagccccagc ctgcctcccg gcgcccagat gcccgccatg ccctccagcg      360

gccccgggga caccagcagc tctgctgcgg agcgggagga ggaccgaaag gacggagagg      420

agcaggagga gccgcgtggc aaggaggagc gccaagagcc cagcaccacg gcacggaagg      480

tggggcggcc tgggaggaag cgcaagcacc ccccggtgga aagcggtgac acgccaaagg      540

accctgcggt gatctccaag tccccatcca tggcccagga ctcaggcgcc tcagagctat      600

tacccaatgg ggacttggag aagcggagtg agccccagcc agaggagggg agccctgctg      660

gggggcagaa gggcggggcc ccagcagagg gagagggtgc agctgagacc ctgcctgaag      720

cctcaagagc agtggaaaat ggctgctgca cccccaagga gggccgagga gcccctgcag      780

aagcgggcaa agaacagaag gagaccaaca tcgaatccat gaaaatggag ggctcccggg      840

gccggctgcg gggtggcttg ggctgggagt ccagcctccg tcagcggccc atgccgaggc      900

tcaccttcca ggcgggggac ccctactaca tcagcaagcg caagcgggac gagtggctgg      960

cacgctggaa aagggaggct gagaagaaag ccaaggtcat tgcaggaatg aatgctgtgg     1020

aagaaaacca ggggcccggg gagtctcaga aggtggagga ggccagccct cctgctgtgc     1080

agcagcccac tgaccccgca tcccccactg tggctaccac gcctgagccc gtggggtccg     1140

atgctgggga caagaatgcc accaaagcag gcgatgacga gccagagtac gaggacggcc     1200

ggggctttgg cattggggag ctggtgtggg ggaaactgcg gggcttctcc tggtggccag     1260

gccgcattgt gtcttggtgg atgacgggcc ggagccgagc agctgaaggc acccgctggg     1320

tcatgtggtt cggagacggc aaattctcag tggtgtgtgt tgagaagctg atgccgctga     1380

gctcgttttg cagtgcgttc caccaggcca cgtacaacaa gcagcccatg taccgcaaag     1440

ccatctacga ggtcctgcag gtggccagca gccgcgcggg gaagctgttc ccggtgtgcc     1500

acgacagcga tgagagtgac actgccaagg ccgtggaggt gcagaacaag cccatgattg     1560

aatgggccct ggggggcttc cagccttctg gccctaaggg cctggagcca ccagaagaag     1620

agaagaatcc ctacaaagaa gtgtacacgg acatgtgggt ggaacctgag gcagctgcct     1680

acgcaccacc tccaccagcc aaaaagcccc ggaagagcac agcggagaag cccaaggtca     1740

aggagattat tgatgagcgc acaagagagc ggctggtgta cgaggtgcgg cagaagtgcc     1800

ggaacattga ggacatctgc atctcctgtg ggagcctcaa tgttaccctg gaacaccccc     1860

tcttcgttgg aggaatgtgc caaaactgca agaactgctt tctggagtgt gcgtaccagt     1920

acgacgacga cggctaccag tcctactgca ccatctgctg tgggggccgt gaggtgctca     1980

tgtgcggaaa caacaactgc tgcaggtgct tttgcgtgga gtgtgtggac ctcttggtgg     2040

ggccgggggc tgcccaggca gccattaagg aagacccctg gaactgctac atgtgcgggc     2100

acaagggtac ctacgggctg ctgcggcggc gagaggactg gccctcccgg ctccagatgt     2160

tcttcgctaa taaccacgac caggaatttg accctccaaa ggtttaccca cctgtcccag     2220

ctgagaagag gaagcccatc cgggtgctgt ctctctttga tggaatcgct acagggctcc     2280

tggtgctgaa ggacttgggc attcaggtgg accgctacat tgcctcggag gtgtgtgagg     2340

actccatcac ggtgggcatg gtgcggcacc aggggaagat catgtacgtc ggggacgtcc     2400

gcagcgtcac acagaagcat atccaggagt ggggcccatt cgatctggtg attgggggca     2460

gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa gggcctctac gagggcactg     2520

gccggctctt ctttgagttc taccgcctcc tgcatgatgc gcggcccaag gagggagatg     2580

atcgcccctt cttctggctc tttgagaatg tggtggccat gggcgttagt gacaagaggg     2640

acatctcgcg atttctcgag tccaaccctg tgatgattga tgccaaagaa gtgtcagctg     2700

cacacagggc ccgctacttc tggggtaacc ttcccggtat gaacaggccg ttggcatcca     2760

ctgtgaatga taagctggag ctgcaggagt gtctggagca tggcaggata gccaagttca     2820

gcaaagtgag gaccattact acgaggtcaa actccataaa gcagggcaaa gaccagcatt     2880

ttcctgtctt catgaatgag aaagaggaca tcttatggtg cactgaaatg gaaagggtat     2940

ttggtttccc agtccactat actgacgtct ccaacatgag ccgcttggcg aggcagagac     3000

tgctgggccg gtcatggagc gtgccagtca tccgccacct cttcgctccg ctgaaggagt     3060

attttgcgtg tgtgtaaggg acatgggggc aaactgaggt agcgacacaa agttaaacaa     3120

acaaacaaaa aacacaaaac ataataaaac accaagaaca tgaggatgga gagaagtatc     3180

agcacccaga agagaaaaag gaatttaaaa caaaaaccac agaggcggaa ataccggagg     3240

gctttgcctt gcgaaaaggg ttggacatca tctcctgatt tttcaatgtt attcttcagt     3300

cctatttaaa aacaaaacca agctcccttc ccttcctccc ccttcccttt tttttcggtc     3360

agacctttta ttttctactc ttttcagagg ggttttctgt ttgtttgggt tttgtttctt     3420

gctgtgactg aaacaagaag gttattgcag caaaaatcag taacaaaaaa tagtaacaat     3480

accttgcaga ggaaaggtgg gagagaggaa aaaaggaaat tctatagaaa tctatatatt     3540

gggttgtttt tttttttgtt ttttgttttt tttttttggg tttttttttt tactatatat     3600

cttttttttg ttgtctctag cctgatcaga taggagcaca agcaggggac ggaaagagag     3660

agacactcag gcggcagcat tccctcccag ccactgagct gtcgtgccag caccattcct     3720

ggtcacgcaa aacagaaccc agttagcagc agggagacga gaacaccaca caagacattt     3780

ttctacagta tttcaggtgc ctaccacaca ggaaaccttg aagaaaatca gtttctagaa     3840

gccgctgtta cctcttgttt acagtttata tatatatgat agatatgaga tatatatata     3900

aaaggtactg ttaactactg tacaacccga cttcataatg gtgctttcaa acagcgagat     3960

gagtaaaaac atcagcttcc acgttgcctt ctgcgcaaag ggtttcacca aggatggaga     4020

aagggagaca gcttgcagat ggcgcgttct cacggtgggc tcttcccctt ggtttgtaac     4080

gaagtgaagg aggagaactt gggagccagg ttctccctgc caaaaagggg gctagatgag     4140

gtggtcgggc ccgtggacag ctgagagtgg gattcatcca gactcatgca ataacccttt     4200

gattgttttc taaaaggaga ctccctcggc aagatggcag agggtacgga gtcttcaggc     4260

ccagtttctc actttagcca attcgagggc tccttgtggt gggatcagaa ctaatccaga     4320

gtgtgggaaa gtgacagtca aaaccccacc tggagcaaat aaaaaaacat acaaaacgta     4380

ctggtgcttt cctgt                                                      4395


<210>  10
<211>  912
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Ala Met Pro Ser Ser Gly Pro Gly Asp Thr Ser Ser Ser Ala 
1               5                   10                  15      


Ala Glu Arg Glu Glu Asp Arg Lys Asp Gly Glu Glu Gln Glu Glu Pro 
            20                  25                  30          


Arg Gly Lys Glu Glu Arg Gln Glu Pro Ser Thr Thr Ala Arg Lys Val 
        35                  40                  45              


Gly Arg Pro Gly Arg Lys Arg Lys His Pro Pro Val Glu Ser Gly Asp 
    50                  55                  60                  


Thr Pro Lys Asp Pro Ala Val Ile Ser Lys Ser Pro Ser Met Ala Gln 
65                  70                  75                  80  


Asp Ser Gly Ala Ser Glu Leu Leu Pro Asn Gly Asp Leu Glu Lys Arg 
                85                  90                  95      


Ser Glu Pro Gln Pro Glu Glu Gly Ser Pro Ala Gly Gly Gln Lys Gly 
            100                 105                 110         


Gly Ala Pro Ala Glu Gly Glu Gly Ala Ala Glu Thr Leu Pro Glu Ala 
        115                 120                 125             


Ser Arg Ala Val Glu Asn Gly Cys Cys Thr Pro Lys Glu Gly Arg Gly 
    130                 135                 140                 


Ala Pro Ala Glu Ala Gly Lys Glu Gln Lys Glu Thr Asn Ile Glu Ser 
145                 150                 155                 160 


Met Lys Met Glu Gly Ser Arg Gly Arg Leu Arg Gly Gly Leu Gly Trp 
                165                 170                 175     


Glu Ser Ser Leu Arg Gln Arg Pro Met Pro Arg Leu Thr Phe Gln Ala 
            180                 185                 190         


Gly Asp Pro Tyr Tyr Ile Ser Lys Arg Lys Arg Asp Glu Trp Leu Ala 
        195                 200                 205             


Arg Trp Lys Arg Glu Ala Glu Lys Lys Ala Lys Val Ile Ala Gly Met 
    210                 215                 220                 


Asn Ala Val Glu Glu Asn Gln Gly Pro Gly Glu Ser Gln Lys Val Glu 
225                 230                 235                 240 


Glu Ala Ser Pro Pro Ala Val Gln Gln Pro Thr Asp Pro Ala Ser Pro 
                245                 250                 255     


Thr Val Ala Thr Thr Pro Glu Pro Val Gly Ser Asp Ala Gly Asp Lys 
            260                 265                 270         


Asn Ala Thr Lys Ala Gly Asp Asp Glu Pro Glu Tyr Glu Asp Gly Arg 
        275                 280                 285             


Gly Phe Gly Ile Gly Glu Leu Val Trp Gly Lys Leu Arg Gly Phe Ser 
    290                 295                 300                 


Trp Trp Pro Gly Arg Ile Val Ser Trp Trp Met Thr Gly Arg Ser Arg 
305                 310                 315                 320 


Ala Ala Glu Gly Thr Arg Trp Val Met Trp Phe Gly Asp Gly Lys Phe 
                325                 330                 335     


Ser Val Val Cys Val Glu Lys Leu Met Pro Leu Ser Ser Phe Cys Ser 
            340                 345                 350         


Ala Phe His Gln Ala Thr Tyr Asn Lys Gln Pro Met Tyr Arg Lys Ala 
        355                 360                 365             


Ile Tyr Glu Val Leu Gln Val Ala Ser Ser Arg Ala Gly Lys Leu Phe 
    370                 375                 380                 


Pro Val Cys His Asp Ser Asp Glu Ser Asp Thr Ala Lys Ala Val Glu 
385                 390                 395                 400 


Val Gln Asn Lys Pro Met Ile Glu Trp Ala Leu Gly Gly Phe Gln Pro 
                405                 410                 415     


Ser Gly Pro Lys Gly Leu Glu Pro Pro Glu Glu Glu Lys Asn Pro Tyr 
            420                 425                 430         


Lys Glu Val Tyr Thr Asp Met Trp Val Glu Pro Glu Ala Ala Ala Tyr 
        435                 440                 445             


Ala Pro Pro Pro Pro Ala Lys Lys Pro Arg Lys Ser Thr Ala Glu Lys 
    450                 455                 460                 


Pro Lys Val Lys Glu Ile Ile Asp Glu Arg Thr Arg Glu Arg Leu Val 
465                 470                 475                 480 


Tyr Glu Val Arg Gln Lys Cys Arg Asn Ile Glu Asp Ile Cys Ile Ser 
                485                 490                 495     


Cys Gly Ser Leu Asn Val Thr Leu Glu His Pro Leu Phe Val Gly Gly 
            500                 505                 510         


Met Cys Gln Asn Cys Lys Asn Cys Phe Leu Glu Cys Ala Tyr Gln Tyr 
        515                 520                 525             


Asp Asp Asp Gly Tyr Gln Ser Tyr Cys Thr Ile Cys Cys Gly Gly Arg 
    530                 535                 540                 


Glu Val Leu Met Cys Gly Asn Asn Asn Cys Cys Arg Cys Phe Cys Val 
545                 550                 555                 560 


Glu Cys Val Asp Leu Leu Val Gly Pro Gly Ala Ala Gln Ala Ala Ile 
                565                 570                 575     


Lys Glu Asp Pro Trp Asn Cys Tyr Met Cys Gly His Lys Gly Thr Tyr 
            580                 585                 590         


Gly Leu Leu Arg Arg Arg Glu Asp Trp Pro Ser Arg Leu Gln Met Phe 
        595                 600                 605             


Phe Ala Asn Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro 
    610                 615                 620                 


Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe 
625                 630                 635                 640 


Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val 
            660                 665                 670         


Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg 
        675                 680                 685             


Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val 
    690                 695                 700                 


Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg 
705                 710                 715                 720 


Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg 
                725                 730                 735     


Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe 
            740                 745                 750         


Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp 
        755                 760                 765             


Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu 
    770                 775                 780                 


Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly 
785                 790                 795                 800 


Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln 
                805                 810                 815     


Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr 
            820                 825                 830         


Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe 
        835                 840                 845             


Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met 
    850                 855                 860                 


Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met 
865                 870                 875                 880 


Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro 
                885                 890                 895     


Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val 
            900                 905                 910         


<210>  11
<211>  2591
<212>  DNA
<213>  Homo sapiens

<400>  11
gatgggattg gggttttccc ctcccatgtg ctcaagactg gcgctaaaag ttttgagctt       60

ctcaaaagtc tagagccacc gtccagggag caggtagctg ctgggctccg gggacacttt      120

gcgttcgggc tgggagcgtg ctttccacga cggtgacacg cttccctgga ttggcagcca      180

gactgccttc cgggtcactg ccatggagga gccgcagtca gatcctagcg tcgagccccc      240

tctgagtcag gaaacatttt cagacctatg gaaactactt cctgaaaaca acgttctgtc      300

ccccttgccg tcccaagcaa tggatgattt gatgctgtcc ccggacgata ttgaacaatg      360

gttcactgaa gacccaggtc cagatgaagc tcccagaatg ccagaggctg ctccccccgt      420

ggcccctgca ccagcagctc ctacaccggc ggcccctgca ccagccccct cctggcccct      480

gtcatcttct gtcccttccc agaaaaccta ccagggcagc tacggtttcc gtctgggctt      540

cttgcattct gggacagcca agtctgtgac ttgcacgtac tcccctgccc tcaacaagat      600

gttttgccaa ctggccaaga cctgccctgt gcagctgtgg gttgattcca cacccccgcc      660

cggcacccgc gtccgcgcca tggccatcta caagcagtca cagcacatga cggaggttgt      720

gaggcgctgc ccccaccatg agcgctgctc agatagcgat ggtctggccc ctcctcagca      780

tcttatccga gtggaaggaa atttgcgtgt ggagtatttg gatgacagaa acacttttcg      840

acatagtgtg gtggtgccct atgagccgcc tgaggttggc tctgactgta ccaccatcca      900

ctacaactac atgtgtaaca gttcctgcat gggcggcatg aaccggaggc ccatcctcac      960

catcatcaca ctggaagact ccagtggtaa tctactggga cggaacagct ttgaggtgcg     1020

tgtttgtgcc tgtcctggga gagaccggcg cacagaggaa gagaatctcc gcaagaaagg     1080

ggagcctcac cacgagctgc ccccagggag cactaagcga gcactgccca acaacaccag     1140

ctcctctccc cagccaaaga agaaaccact ggatggagaa tatttcaccc ttcagatccg     1200

tgggcgtgag cgcttcgaga tgttccgaga gctgaatgag gccttggaac tcaaggatgc     1260

ccaggctggg aaggagccag gggggagcag ggctcactcc agccacctga agtccaaaaa     1320

gggtcagtct acctcccgcc ataaaaaact catgttcaag acagaagggc ctgactcaga     1380

ctgacattct ccacttcttg ttccccactg acagcctccc acccccatct ctccctcccc     1440

tgccattttg ggttttgggt ctttgaaccc ttgcttgcaa taggtgtgcg tcagaagcac     1500

ccaggacttc catttgcttt gtcccggggc tccactgaac aagttggcct gcactggtgt     1560

tttgttgtgg ggaggaggat ggggagtagg acataccagc ttagatttta aggtttttac     1620

tgtgagggat gtttgggaga tgtaagaaat gttcttgcag ttaagggtta gtttacaatc     1680

agccacattc taggtagggg cccacttcac cgtactaacc agggaagctg tccctcactg     1740

ttgaattttc tctaacttca aggcccatat ctgtgaaatg ctggcatttg cacctacctc     1800

acagagtgca ttgtgagggt taatgaaata atgtacatct ggccttgaaa ccacctttta     1860

ttacatgggg tctagaactt gacccccttg agggtgcttg ttccctctcc ctgttggtcg     1920

gtgggttggt agtttctaca gttgggcagc tggttaggta gagggagttg tcaagtctct     1980

gctggcccag ccaaaccctg tctgacaacc tcttggtgaa ccttagtacc taaaaggaaa     2040

tctcacccca tcccacaccc tggaggattt catctcttgt atatgatgat ctggatccac     2100

caagacttgt tttatgctca gggtcaattt cttttttctt tttttttttt ttttttcttt     2160

ttctttgaga ctgggtctcg ctttgttgcc caggctggag tggagtggcg tgatcttggc     2220

ttactgcagc ctttgcctcc ccggctcgag cagtcctgcc tcagcctccg gagtagctgg     2280

gaccacaggt tcatgccacc atggccagcc aacttttgca tgttttgtag agatggggtc     2340

tcacagtgtt gcccaggctg gtctcaaact cctgggctca ggcgatccac ctgtctcagc     2400

ctcccagagt gctgggatta caattgtgag ccaccacgtc cagctggaag ggtcaacatc     2460

ttttacattc tgcaagcaca tctgcatttt caccccaccc ttcccctcct tctccctttt     2520

tatatcccat ttttatatcg atctcttatt ttacaataaa actttgctgc cacctgtgtg     2580

tctgaggggt g                                                          2591


<210>  12
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  13
<211>  1818
<212>  DNA
<213>  Homo sapiens

<400>  13
tccccggcaa ggcccaatgg ggcggcaggc ccggcagccc cgccccggtg gtgcccgcgc       60

ggccagcgcc cgccaggccc agcgttagcc cgcggccagg cagccgggag gagcggcgcg      120

cgctcggacc tctcccgccc tgctcgttcg ctctccagct tgggatggcc ggctacctgc      180

gggtcgtgcg ctcgctctgc agagcctcag gctcgcggcc ggcctgggcg ccggcggccc      240

tgacagcccc cacctcgcaa gagcagccgc ggcgccacta tgccgacaaa aggatcaagg      300

tggcgaagcc cgtggtggag atggatggtg atgagatgac ccgtattatc tggcagttca      360

tcaaggagaa gctcatcctg ccccacgtgg acatccagct aaagtatttt gacctcgggc      420

tcccaaaccg tgaccagact gatgaccagg tcaccattga ctctgcactg gccacccaga      480

agtacagtgt ggctgtcaag tgtgccacca tcacccctga tgaggcccgt gtggaagagt      540

tcaagctgaa gaagatgtgg aaaagtccca atggaactat ccggaacatc ctggggggga      600

ctgtcttccg ggagcccatc atctgcaaaa acatcccacg cctagtccct ggctggacca      660

agcccatcac cattggcagg cacgcccatg gcgaccagta caaggccaca gactttgtgg      720

cagaccgggc cggcactttc aaaatggtct tcaccccaaa agatggcagt ggtgtcaagg      780

agtgggaagt gtacaacttc cccgcaggcg gcgtgggcat gggcatgtac aacaccgacg      840

agtccatctc aggttttgcg cacagctgct tccagtatgc catccagaag aaatggccgc      900

tgtacatgag caccaagaac accatactga aagcctacga tgggcgtttc aaggacatct      960

tccaggagat ctttgacaag cactataaga ccgacttcga caagaataag atctggtatg     1020

agcaccggct cattgatgac atggtggctc aggtcctcaa gtcttcgggt ggctttgtgt     1080

gggcctgcaa gaactatgac ggagatgtgc agtcagacat cctggcccag ggctttggct     1140

cccttggcct gatgacgtcc gtcctggtct gccctgatgg gaagacgatt gaggctgagg     1200

ccgctcatgg gaccgtcacc cgccactatc gggagcacca gaagggccgg cccaccagca     1260

ccaaccccat cgccagcatc tttgcctgga cacgtggcct ggagcaccgg gggaagctgg     1320

atgggaacca agacctcatc aggtttgccc agatgctgga gaaggtgtgc gtggagacgg     1380

tggagagtgg agccatgacc aaggacctgg cgggctgcat tcacggcctc agcaatgtga     1440

agctgaacga gcacttcctg aacaccacgg acttcctcga caccatcaag agcaacctgg     1500

acagagccct gggcaggcag tagggggagg cgccacccat ggctgcagtg gaggggccag     1560

ggctgagccg gcgggtcctc ctgagcgcgg cagagggtga gcctcacagc ccctctctgg     1620

aggcctttct aggggatgtt tttttataag ccagatgttt ttaaaagcat atgtgtgttt     1680

cccctcatgg tgacgtgagg caggagcagt gcgttttacc tcagccagtc agtatgtttt     1740

gcatactgta atttatattg cccttggaac acatggtgcc atatttagct actaaaaagc     1800

tcttcacaaa aaaaaaaa                                                   1818


<210>  14
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
1               5                   10                  15      


Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
            20                  25                  30          


Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
        35                  40                  45              


Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
    50                  55                  60                  


Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
65                  70                  75                  80  


Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                85                  90                  95      


Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
            100                 105                 110         


Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
        115                 120                 125             


Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
    130                 135                 140                 


Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
145                 150                 155                 160 


Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                165                 170                 175     


Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
            180                 185                 190         


Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
        195                 200                 205             


Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
    210                 215                 220                 


Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
225                 230                 235                 240 


Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                245                 250                 255     


Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
            260                 265                 270         


His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
        275                 280                 285             


Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
    290                 295                 300                 


Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
305                 310                 315                 320 


Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                325                 330                 335     


Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
            340                 345                 350         


Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
        355                 360                 365             


Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
    370                 375                 380                 


Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
385                 390                 395                 400 


Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                405                 410                 415     


Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
            420                 425                 430         


Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
        435                 440                 445             


Leu Gly Arg Gln 
    450         


<210>  15
<211>  2708
<212>  DNA
<213>  Homo sapiens

<400>  15
ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt       60

ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg      120

gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg      180

acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg      240

gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga      300

tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt      360

aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc      420

attgcgcggg actagggagt gttcggtgac cagtgacttg gattttccaa cacaagtcat      480

cccattaaag actctgaatg cagttgcttc agtacccata atgtattctt ggtctcccct      540

acagcagaat tttatggtgg aagatgaaac tgttttacat aacattcctt atatgggaga      600

tgaagtttta gatcaggatg gtactttcat tgaagaacta ataaaaaatt atgatgggaa      660

agtacacggg gatagagaat gtgggtttat aaatgatgaa atttttgtgg agttggtgaa      720

tgcccttggt caatataatg atgatgacga tgatgatgat ggagacgatc ctgaagaaag      780

agaagaaaag cagaaagatc tggaggatca ccgagatgat aaagaaagcc gcccacctcg      840

gaaatttcct tctgataaaa tttttgaagc catttcctca atgtttccag ataagggcac      900

agcagaagaa ctaaaggaaa aatataaaga actcaccgaa cagcagctcc caggcgcact      960

tcctcctgaa tgtaccccca acatagatgg accaaatgct aaatctgttc agagagagca     1020

aagcttacac tcctttcata cgcttttctg taggcgatgt tttaaatatg actgcttcct     1080

acatcctttt catgcaacac ccaacactta taagcggaag aacacagaaa cagctctaga     1140

caacaaacct tgtggaccac agtgttacca gcatttggag ggagcaaagg agtttgctgc     1200

tgctctcacc gctgagcgga taaagacccc accaaaacgt ccaggaggcc gcagaagagg     1260

acggcttccc aataacagta gcaggcccag cacccccacc attaatgtgc tggaatcaaa     1320

ggatacagac agtgataggg aagcagggac tgaaacgggg ggagagaaca atgataaaga     1380

agaagaagag aagaaagatg aaacttcgag ctcctctgaa gcaaattctc ggtgtcaaac     1440

accaataaag atgaagccaa atattgaacc tcctgagaat gtggagtgga gtggtgctga     1500

agcctcaatg tttagagtcc tcattggcac ttactatgac aatttctgtg ccattgctag     1560

gttaattggg accaaaacat gtagacaggt gtatgagttt agagtcaaag aatctagcat     1620

catagctcca gctcccgctg aggatgtgga tactcctcca aggaaaaaga agaggaaaca     1680

ccggttgtgg gctgcacact gcagaaagat acagctgaaa aaggacggct cctctaacca     1740

tgtttacaac tatcaaccct gtgatcatcc acggcagcct tgtgacagtt cgtgcccttg     1800

tgtgatagca caaaattttt gtgaaaagtt ttgtcaatgt agttcagagt gtcaaaaccg     1860

ctttccggga tgccgctgca aagcacagtg caacaccaag cagtgcccgt gctacctggc     1920

tgtccgagag tgtgaccctg acctctgtct tacttgtgga gccgctgacc attgggacag     1980

taaaaatgtg tcctgcaaga actgcagtat tcagcggggc tccaaaaagc atctattgct     2040

ggcaccatct gacgtggcag gctgggggat ttttatcaaa gatcctgtgc agaaaaatga     2100

attcatctca gaatactgtg gagagattat ttctcaagat gaagctgaca gaagagggaa     2160

agtgtatgat aaatacatgt gcagctttct gttcaacttg aacaatgatt ttgtggtgga     2220

tgcaacccgc aagggtaaca aaattcgttt tgcaaatcat tcggtaaatc caaactgcta     2280

tgcaaaagtt atgatggtta acggtgatca caggataggt atttttgcca agagagccat     2340

ccagactggc gaagagctgt tttttgatta cagatacagc caggctgatg ccctgaagta     2400

tgtcggcatc gaaagagaaa tggaaatccc ttgacatctg ctacctcctc ccccctcctc     2460

tgaaacagct gccttagctt caggaacctc gagtactgtg ggcaatttag aaaaagaaca     2520

tgcagtttga aattctgaat ttgcaaagta ctgtaagaat aatttatagt aatgagttta     2580

aaaatcaact ttttattgcc ttctcaccag ctgcaaagtg ttttgtacca gtgaattttt     2640

gcaataatgc agtatggtac atttttcaac tttgaataaa gaatacttga acttgtcctt     2700

gttgaatc                                                              2708


<210>  16
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  17
<211>  2402
<212>  DNA
<213>  Homo sapiens

<400>  17
gggctgagga ggcggggcct gggaggggac aaagccggga agaggaaaag ctcggaccta       60

ccctgtggtc ccgggtttct gcagagtcta cttcagaagc ggaggcactg ggagtccggt      120

ttgggattgc caggctgtgg ttgtgagtct gagcttgtga gcggctgtgg cgccccaact      180

cttcgccagc atatcatccc ggcaggcgat aaactacatt cagttgagtc tgcaagactg      240

ggaggaactg gggtgataag aaatctattc actgtcaagg tttattgaag tcaaaatgtc      300

caaaaaaatc agtggcggtt ctgtggtaga gatgcaagga gatgaaatga cacgaatcat      360

ttgggaattg attaaagaga aactcatttt tccctacgtg gaattggatc tacatagcta      420

tgatttaggc atagagaatc gtgatgccac caacgaccaa gtcaccaagg atgctgcaga      480

agctataaag aagcataatg ttggcgtcaa atgtgccact atcactcctg atgagaagag      540

ggttgaggag ttcaagttga aacaaatgtg gaaatcacca aatggcacca tacgaaatat      600

tctgggtggc acggtcttca gagaagccat tatctgcaaa aatatccccc ggcttgtgag      660

tggatgggta aaacctatca tcataggtcg tcatgcttat ggggatcaat acagagcaac      720

tgattttgtt gttcctgggc ctggaaaagt agagataacc tacacaccaa gtgacggaac      780

ccaaaaggtg acatacctgg tacataactt tgaagaaggt ggtggtgttg ccatggggat      840

gtataatcaa gataagtcaa ttgaagattt tgcacacagt tccttccaaa tggctctgtc      900

taagggttgg cctttgtatc tgagcaccaa aaacactatt ctgaagaaat atgatgggcg      960

ttttaaagac atctttcagg agatatatga caagcagtac aagtcccagt ttgaagctca     1020

aaagatctgg tatgagcata ggctcatcga cgacatggtg gcccaagcta tgaaatcaga     1080

gggaggcttc atctgggcct gtaaaaacta tgatggtgac gtgcagtcgg actctgtggc     1140

ccaagggtat ggctctctcg gcatgatgac cagcgtgctg gtttgtccag atggcaagac     1200

agtagaagca gaggctgccc acgggactgt aacccgtcac taccgcatgt accagaaagg     1260

acaggagacg tccaccaatc ccattgcttc catttttgcc tggaccagag ggttagccca     1320

cagagcaaag cttgataaca ataaagagct tgccttcttt gcaaatgctt tggaagaagt     1380

ctctattgag acaattgagg ctggcttcat gaccaaggac ttggctgctt gcattaaagg     1440

tttacccaat gtgcaacgtt ctgactactt gaatacattt gagttcatgg ataaacttgg     1500

agaaaacttg aagatcaaac tagctcaggc caaactttaa gttcatacct gagctaagaa     1560

ggataattgt cttttggtaa ctaggtctac aggtttacat ttttctgtgt tacactcaag     1620

gataaaggca aaatcaattt tgtaatttgt ttagaagcca gagtttatct tttctataag     1680

tttacagcct ttttcttata tatacagtta ttgccacctt tgtgaacatg gcaagggact     1740

tttttacaat ttttatttta ttttctagta ccagcctagg aattcggtta gtactcattt     1800

gtattcactg tcactttttc tcatgttcta attataaatg accaaaatca agattgctca     1860

aaagggtaaa tgatagccac agtattgctc cctaaaatat gcataaagta gaaattcact     1920

gccttcccct cctgtccatg accttgggca cagggaagtt ctggtgtcat agatatcccg     1980

ttttgtgagg tagagctgtg cattaaactt gcacatgact ggaacgaagt atgagtgcaa     2040

ctcaaatgtg ttgaagatac tgcagtcatt tttgtaaaga ccttgctgaa tgtttccaat     2100

agactaaata ctgtttaggc cgcaggagag tttggaatcc ggaataaata ctacctggag     2160

gtttgtcctc tccatttttc tctttctcct cctggcctgg cctgaatatt atactactct     2220

aaatagcata tttcatccaa gtgcaataat gtaagctgaa tcttttttgg acttctgctg     2280

gcctgtttta tttcttttat ataaatgtga tttctcagaa attgatatta aacactatct     2340

tatcttctcc tgaactgttg attttaatta aaattaagtg ctaattacca ttaaaaaaaa     2400

aa                                                                    2402


<210>  18
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


<210>  19
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  19
agaaaggagt ggggttgaaa agcgcttgcg caggacggct acggtacggg ggtgggaggg       60

cttcggagca cgcgcgcgga ggcgggactt gggaagcgct cgcgagatct tcagggtcta      120

tatataagcg cggggagcct gcgtcctttc cctggtgtga ttccgtcctg cgcggttgtt      180

ctctggagca gcgttctttt atctccgtcc gccttctctc ctacctaagt gcgtgccgcc      240

acccgatgga agattcgatg gacatggaca tgagccccct gaggccccag aactatcttt      300

tcggttgtga actaaaggcc gacaaagatt atcactttaa ggtggataat gatgaaaatg      360

agcaccagtt atctttaaga acggtcagtt taggggctgg tgcaaaggat gagttgcaca      420

ttgttgaagc agaggcaatg aattacgaag gcagtccaat taaagtaaca ctggcaactt      480

tgaaaatgtc tgtacagcca acggtttccc ttgggggctt tgaaataaca ccaccagtgg      540

tcttaaggtt gaagtgtggt tcagggccag tgcatattag tggacagcac ttagtagctg      600

tggaggaaga tgcagagtca gaagatgaag aggaggagga tgtgaaactc ttaagtatat      660

ctggaaagcg gtctgcccct ggaggtggta gcaaggttcc acagaaaaaa gtaaaacttg      720

ctgctgatga agatgatgac gatgatgatg aagaggatga tgatgaagat gatgatgatg      780

atgattttga tgatgaggaa gctgaagaaa aagcgccagt gaagaaatct atacgagata      840

ctccagccaa aaatgcacaa aagtcaaatc agaatggaaa agactcaaaa ccatcatcaa      900

caccaagatc aaaaggacaa gaatccttca agaaacagga aaaaactcct aaaacaccaa      960

aaggacctag ttctgtagaa gacattaaag caaaaatgca agcaagtata gaaaaaggtg     1020

gttctcttcc caaagtggaa gccaaattca tcaattatgt gaagaattgc ttccggatga     1080

ctgaccaaga ggctattcaa gatctctggc agtggaggaa gtctctttaa gaaaatagtt     1140

taaacaattt gttaaaaaat tttccgtctt atttcatttc tgtaacagtt gatatctggc     1200

tgtccttttt ataatgcaga gtgagaactt tccctaccgt gtttgataaa tgttgtccag     1260

gttctattgc caagaatgtg ttgtccaaaa tgcctgttta gtttttaaag atggaactcc     1320

accctttgct tggttttaag tatgtatgga atgttatgat aggacatagt agtagcggtg     1380

gtcagacatg gaaatggtgg ggagacaaaa atatacatgt gaaataaaac tcagtatttt     1440

aataaagta                                                             1449


<210>  20
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala 
    130                 135                 140                 


Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala 
145                 150                 155                 160 


Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp 
                165                 170                 175     


Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val 
            180                 185                 190         


Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn 
        195                 200                 205             


Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly 
    210                 215                 220                 


Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly 
225                 230                 235                 240 


Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu 
                245                 250                 255     


Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val 
            260                 265                 270         


Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp 
        275                 280                 285             


Gln Trp Arg Lys Ser Leu 
    290                 


<210>  21
<211>  4772
<212>  DNA
<213>  Homo sapiens

<400>  21
aagggcgctc cgcgagcccg tctctcctcg aatgaaagga aacaacctcc ggcgacagag       60

ccccgctctc aggcactgct ggagaaccga gaccgacttc tttctcttta ccctcattgg      120

cgcttctctc ctgcagtccg cctctgggcc ctgccgcatt tcttgagact taaagtggca      180

ttctaaaggc aatttaaaaa tcatgtcaag ctcagttgaa cagaaaaaag ggcctacaag      240

acagcgcaaa tgtggctttt gtaagtcaaa tagagacaag gaatgtggac agttactaat      300

atctgaaaac cagaaggtgg cagcgcacca taagtgcatg ctcttttcat ctgctttggt      360

atcatcacac tctgataatg aaagtcttgg tggattttct attgaagatg tccaaaagga      420

aattaaaaga ggcacgaagc tgatgtgttc tttgtgccat tgtcctggag caacaattgg      480

ttgtgatgtg aaaacatgtc acaggacata ccactaccac tgtgcattgc atgataaagc      540

tcaaatacga gagaaacctt cacaaggaat ttacatggtc tattgccgaa aacacaagaa      600

aactgcacat aactccgaag ctgatttaga agaaagtttt aatgaacatg aactggagcc      660

ctcatcacct aaaagtaaaa agaaaagtcg caaaggaagg ccaagaaaaa ctaattttaa      720

agggctgtca gaagatacca ggtccacatc ctcccatgga acagatgaaa tggaaagtag      780

ttcctataga gataggtctc cacacagaag cagccctagt gacaccaggc ctaaatgtgg      840

attttgccat gtaggggagg aagaaaatga agcacgagga aaactgcata tatttaatgc      900

caagaaggca gctgcccatt ataagtgcat gttgttttct tctggcacag tccagctcac      960

aacaacatca agagcagaat ttggagactt tgatattaaa actgtacttc aggagattaa     1020

acgaggaaaa agaatgaaat gtacactttg cagtcagcct ggtgctacta ttggatgtga     1080

aataaaagcc tgtgttaaga cttaccatta ccactgtgga gtacaagaca aagctaaata     1140

cattgaaaat atgtcacgag gaatttacaa actatactgt aaaaatcata gtggaaatga     1200

tgagagagat gaagaagatg aggaacgaga gagtaaaagc cgaggaaaag tagaaattga     1260

tcagcaacaa ctaactcagc agcaacttaa tggaaactag gtatgaaagt taattatatg     1320

ggatctgttg tcaggataca atacacactg atatatacat gttgaagtaa tggtatgcag     1380

taagattttt tttaatccta ttatgtttag ttaagagcat gttactaaaa tgctgaggat     1440

tttgtaggct tgcatagtag ttgtttttta actagctgat tttgtaacca taaaaacaag     1500

ctatctgctt tatcaataag tgtagttgta atgtcaaatc aataagatat tcacactcct     1560

caataacatt atattgattg tgttcccctc aagcatcata ttttacattt ttttatcatc     1620

ttttaaacag gttcatggga cagagttaga aaactgggaa tgaataagac atccataact     1680

actattcttt tttcactgtt ttctaaaatc aaaaagggtt tgtaactttt tactgcccaa     1740

ctcttagatc cttcattgaa ctgcctaaaa atgtcttgtt tgttttatga gccctcacta     1800

gaaggctgag tttgacatgt tgatattacg tagctatagt ttgcagtttc tgggaagcaa     1860

ttgaaacact attaaccctg tgtatagtgt caacagttaa agcagacgaa acgaagtaag     1920

ctatatttct ggactgaaca aagctctgct gtttagagca tttaagtttg tttagtggat     1980

ccatactcaa aggaaagcat aagcaaattt tcctttacaa tgcaaacatg ccactggtgg     2040

cagcacatgg taatttgtgg attttttttt catactcaag taatggaggc tagaaatgaa     2100

gagaaccttc tttttctctt gactttgaca gcacatgcta aaaatctctt ccaagaagta     2160

tgctaaagct tttcatttgg ttcctgttaa agttgttctc actgaccagc atggactcag     2220

gcaactggta atgataagct atgagctcca gtgcttttgc caaaattctc ttgacagcac     2280

acctcctctc tttccatgtt atacaaagga cttctggcaa aatgattgag tccttcaagt     2340

ttaaactaac atttggcaac agcaaattaa acgtttttaa gatgtaaaga aagggttacc     2400

gcttgctaag gacttcagac accatgtccg aaacctgttc ctctcaagtg ccctgttgtg     2460

tggaacactt cacatattgg cgcacagtac gtaaggaggt ctcatgtgct gtaggagtaa     2520

aaaagtcttt gcataaaaca gtatttattt ttacttttgt gaccactatt ttagaaactt     2580

tatttaatat tttaatgttt tcagtcattg ctttggttat ctataaaata ggcttttgtg     2640

ccctactttt cttcttgtag ggcttggtgg tgttttatcg attgtcagaa ttgtttttga     2700

aagcctaaga acccagcttt ttagaaagga ttttcacact ggcatttcta ggtagtgata     2760

ttttcttcca cttacctgct gaagcacatt tatgcatttc tttatggcaa aaccaaataa     2820

ctttagttgt ggtctgcctg atactaccat agcacctcag taccaagggg agggattttg     2880

actagttgaa ttattaagcc accacaataa agcagatttt taaataagaa ataataatgt     2940

taacttgact gtacattgag atattctgca gctgatagag cagcatttta aaaatgtaac     3000

aggtggaaaa ttacactgtg cttaatgact gatttttttt taaactgcga gtcccttaag     3060

atcacgtttg tcaagtgtgt attcacacat ttacttaaat caagggactc aatgcttgct     3120

tttattttaa ccatctttta ctatttttag aaggaaacta gctttagtag tgggttgccc     3180

tgtatgtttt ctctttttgc tcttaatatg ccattgggtt tttgtgtgta tgtgattttc     3240

aaaattcatg acttgaagtg caaggacaga tctagatgtt tgtttaccaa gctatgtgac     3300

ttctcccaaa ggatctgtac tttctttcct tacaacagct tgaaaatcat tattttaaaa     3360

tccttaaatc actgtgtcta gatcattttt tacattgtgt gccatagact tacccatggg     3420

acaacagagc tccttcattt ttggacaact actgtaatca tttttttttt aggaaaaatg     3480

gaaggtgccg ggggtaatca tggccagtca ataattatat aaaggagttc aaatactata     3540

gctgtcagtt gatgaatttg ttatgtagta aaatgtatga ctttgtatgg gtttcttcag     3600

ccctttttct gccactagca accagaatag cactttacct tttggttggc tagataagtg     3660

gctgactacc tgtttttctc actgtggtgt gattggctaa acaatctcgc attaaaaatt     3720

caaatgtaaa ttgaattcac atgaaaaatc atgtttggtt gtaaacctcc aatgttttga     3780

ttctctaatc atgttttcgt cacatgctga gtaaaagtgc cttacaatgt aaaaattgta     3840

cagtacttat gttcccaagt agcatcatca tcttctgggt agtaattaca ttgtggtatt     3900

aatatttaga aaaatggacc tcagcagtgt atttactgta catctcttaa gtccttaact     3960

gtagttttaa taagcatgac attatttgat aagtatataa catttacatc atttcaaaaa     4020

atactgccgt tactgtcttt tatgcatatt ttagcctgaa attttgaagc gtcttttttc     4080

tttctttttt ctttttttgt tttgtttttt gttattgata ttaaacagtg taatctttgc     4140

aagcgtatat tgaagattat tctggagcat ttattgcctt accagaaatg ttagtaggaa     4200

atgttcttta gagtagaaag atagacttga gtttctatac ttttaagaag agctctttgt     4260

tcctggggga ggggggcagg gggtgaattt tactttcatc tcaagttatt aaaaacccac     4320

aactgaagta aattttattt caagaatcag cagttttaga atttcagata gtacttgctc     4380

agaagtacat gctactcaag atattaagag ataacaagat ctgtagatct gctattgaat     4440

cagaatctgt gtacttgaac aaatgtgtga atctcaaata tctcaaagca aaagaaaaag     4500

tgttctagag tgttgttgct tttttaaaaa aagcgctgaa gttagaccaa ggtatacagt     4560

tttgttctaa cagacattta ggttaattgt aaagataagg aatgcattat gggtcaaaaa     4620

tcaaacattc ctctcatgtt atgtatattt tgttcctgtt atattggctt tattttcaaa     4680

attgtagttt gtagtattag tttcctttta ttggtattct tgcatatact attcattcaa     4740

taaatgactt atgactttca taaaaaaaaa aa                                   4772


<210>  22
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Ser Ser Val Glu Gln Lys Lys Gly Pro Thr Arg Gln Arg Lys 
1               5                   10                  15      


Cys Gly Phe Cys Lys Ser Asn Arg Asp Lys Glu Cys Gly Gln Leu Leu 
            20                  25                  30          


Ile Ser Glu Asn Gln Lys Val Ala Ala His His Lys Cys Met Leu Phe 
        35                  40                  45              


Ser Ser Ala Leu Val Ser Ser His Ser Asp Asn Glu Ser Leu Gly Gly 
    50                  55                  60                  


Phe Ser Ile Glu Asp Val Gln Lys Glu Ile Lys Arg Gly Thr Lys Leu 
65                  70                  75                  80  


Met Cys Ser Leu Cys His Cys Pro Gly Ala Thr Ile Gly Cys Asp Val 
                85                  90                  95      


Lys Thr Cys His Arg Thr Tyr His Tyr His Cys Ala Leu His Asp Lys 
            100                 105                 110         


Ala Gln Ile Arg Glu Lys Pro Ser Gln Gly Ile Tyr Met Val Tyr Cys 
        115                 120                 125             


Arg Lys His Lys Lys Thr Ala His Asn Ser Glu Ala Asp Leu Glu Glu 
    130                 135                 140                 


Ser Phe Asn Glu His Glu Leu Glu Pro Ser Ser Pro Lys Ser Lys Lys 
145                 150                 155                 160 


Lys Ser Arg Lys Gly Arg Pro Arg Lys Thr Asn Phe Lys Gly Leu Ser 
                165                 170                 175     


Glu Asp Thr Arg Ser Thr Ser Ser His Gly Thr Asp Glu Met Glu Ser 
            180                 185                 190         


Ser Ser Tyr Arg Asp Arg Ser Pro His Arg Ser Ser Pro Ser Asp Thr 
        195                 200                 205             


Arg Pro Lys Cys Gly Phe Cys His Val Gly Glu Glu Glu Asn Glu Ala 
    210                 215                 220                 


Arg Gly Lys Leu His Ile Phe Asn Ala Lys Lys Ala Ala Ala His Tyr 
225                 230                 235                 240 


Lys Cys Met Leu Phe Ser Ser Gly Thr Val Gln Leu Thr Thr Thr Ser 
                245                 250                 255     


Arg Ala Glu Phe Gly Asp Phe Asp Ile Lys Thr Val Leu Gln Glu Ile 
            260                 265                 270         


Lys Arg Gly Lys Arg Met Lys Cys Thr Leu Cys Ser Gln Pro Gly Ala 
        275                 280                 285             


Thr Ile Gly Cys Glu Ile Lys Ala Cys Val Lys Thr Tyr His Tyr His 
    290                 295                 300                 


Cys Gly Val Gln Asp Lys Ala Lys Tyr Ile Glu Asn Met Ser Arg Gly 
305                 310                 315                 320 


Ile Tyr Lys Leu Tyr Cys Lys Asn His Ser Gly Asn Asp Glu Arg Asp 
                325                 330                 335     


Glu Glu Asp Glu Glu Arg Glu Ser Lys Ser Arg Gly Lys Val Glu Ile 
            340                 345                 350         


Asp Gln Gln Gln Leu Thr Gln Gln Gln Leu Asn Gly Asn 
        355                 360                 365 


<210>  23
<211>  7056
<212>  DNA
<213>  Homo sapiens

<400>  23
cacacccacg gcagacacgc acgcacccgg gcgccgaagg gaaagccgcg tctcgccctc       60

ccgccccgcc gtcggtcctg tctcagtccc tcagcagagc gggaaagcgg aggccggagc      120

cgtgacctct gaccccgtgg ttatgcggag ccgccgcatt ccttagcgat cgcggggcag      180

ccgccgctgc cgccgtgggc gactgacgca gcgcgggcgc gtggagccgc cgccgcccct      240

cccccaccgc cgctctcgcg ccagccggtc cccgcgtgcc cgccccttct ccccggccgc      300

acccgagacc tcgcgcgccg ccgctgccac gcgccccccc caccgccgcc gccgccccag      360

ccccgcgcca ccgccccagc ccgcccagcc cggaggtccc gcgtggagct gccgccgccg      420

ccggggagaa ggatgaagga caaacagaag aagaagaagg agcgcacgtg ggccgaggcc      480

gcgcgcctgg tattagaaaa ctactcggat gctccaatga caccaaaaca gattctgcag      540

gtcatagagg cagaaggact aaaggaaatg agaagtggga cttcccctct cgcatgcctc      600

aatgctatgc tacattccaa ttcaagagga ggagaggggt tgttttataa actgcctggc      660

cgaatcagcc ttttcacgct caagaaggat gccctgcagt ggtctcgcca tccagctaca      720

gtggagggag aggagccaga ggacacggct gatgtggaga gctgtgggtc taatgaagcc      780

agcactgtga gtggtgaaaa cgatgtatct cttgatgaaa catcttcgaa cgcatcctgt      840

tctacagaat ctcagagtcg acctctttcc aatcccaggg acagctacag agcttcctca      900

caggcgaaca aacaaaagaa aaagactggg gtgatgctgc ctcgagttgt cctgactcct      960

ctgaaggtaa acggggccca cgtggaatct gcatcagggt tctcgggctg ccacgccgat     1020

ggcgagagcg gcagcccgtc cagcagcagc agcggctctc tggccctggg cagcgctgct     1080

attcgtggcc aggccgaggt cacccaggac cctgccccgc tcctgagagg cttccggaag     1140

ccagccacag gtcaaatgaa gcgcaacaga ggggaagaaa tagattttga gacacctggg     1200

tccattcttg tcaacaccaa cctccgtgcc ctgatcaact ctcggacctt ccatgcctta     1260

ccatcacact tccagcagca gctcctcttc ctcctgcctg aagtagacag acaggtgggg     1320

acggatggcc tgttgcgtct cagcagcagt gcactaaata acgagttttt tacccatgcg     1380

gctcagagct ggcgggagcg cctggctgat ggtgaattta ctcatgagat gcaagtcagg     1440

atacgacagg aaatggagaa ggaaaagaag gtggaacaat ggaaagaaaa gttctttgaa     1500

gactactatg gacagaagct gggtttgacc aaagaagagt cattgcagca gaacgtgggc     1560

caggaggagg ctgaaatcaa aagtggcttg tgtgtcccag gagaatcagt gcgtatacag     1620

cgtggtccag ccacccgaca gcgagatggg cattttaaga aacgctctcg gccagatctc     1680

cgaaccagag ccagaaggaa tctgtacaaa aaacaggagt cagaacaagc aggggttgct     1740

aaggatgcaa aatctgtggc ctcagatgtt cccctctaca aggatgggga ggctaagact     1800

gacccagcag ggctgagcag tccccatctg ccaggcacat cctctgcagc acccgacctg     1860

gagggtcccg aattcccagt tgagtctgtg gcttctcgga tccaggctga gccagacaac     1920

ttggcacgtg cctctgcatc tccagacaga attcctagcc tgcctcagga aactgtggat     1980

caggaaccca aggatcagaa gaggaaatcc tttgagcagg cggcctctgc atcctttccc     2040

gaaaagaagc cccggcttga agatcgtcag tcctttcgta acacaattga aagtgttcac     2100

accgaaaagc cacagcccac taaagaggag cccaaagtcc cgcccatccg gattcaactt     2160

tcacgtatca aaccaccctg ggtggttaaa ggtcagccca cttaccagat atgcccccgg     2220

atcatcccca ccacggagtc ctcctgccgg ggttggactg gcgccaggac cctcgcagac     2280

attaaagccc gtgctctgca ggtccgaggg gcgagaggtc accactgcca tagagaggcg     2340

gccaccactg ccatcggagg ggggggtggc ccgggtggag gtggcggcgg ggccaccgat     2400

gagggaggtg gcagaggcag cagcagtggt gatggtggtg aggcctgtgg ccaccctgag     2460

cccaggggag gcccgagcac ccctggaaag tgtacgtcag atctacagcg aacacaacta     2520

ctgccgcctt atcctctaaa tggggagcat acccaggccg gaactgccat gtccagagct     2580

aggagagagg acctgccttc tctgagaaag gaggaaagct gcctactaca gagggctaca     2640

gttggactca cagatgggct aggagatgcc tcccaactcc ccgttgctcc cactggggac     2700

cagccatgcc aggccttgcc cctactgtcc tcccaaacct cagtagctga gagattagtg     2760

gagcagcctc agttgcatcc ggatgttaga actgaatgtg agtctggcac cacttcctgg     2820

gaaagtgatg atgaggagca aggacccacc gttcctgcag acaatggtcc cattccgtct     2880

ctagtgggag atgatacatt agagaaagga actggccaag ctcttgacag tcatcccact     2940

atgaaggatc ctgtaaatgt gacccccagt tccacacctg aatcctcacc gactgattgc     3000

ctgcagaaca gagcatttga tgacgaatta gggcttggtg gctcatgccc tcctatgagg     3060

gaaagtgata ctagacaaga aaacttgaaa accaaggctc tcgtttctaa cagttctttg     3120

cattggatac ccatcccatc gaatgatgag gtagtgaaac agcccaaacc agaatccaga     3180

gaacacatac catctgttga gccccaggtt ggagaggagt gggagaaagc tgctcccacc     3240

cctcctgcat tgcctgggga tttgacagct gaggagggtc tagatcctct tgacagcctt     3300

acttcactct ggactgtgcc atctcgagga ggcagtgaca gcaatggcag ttactgtcaa     3360

caggtggaca ttgaaaagct gaaaatcaac ggagactctg aagcactgag tcctcacggt     3420

gagtccacgg atacagcctc tgactttgaa ggtcacctca cggaggacag cagtgaggct     3480

gacactagag aagctgcagt gacaaaggga tcttcggtgg acaaggatga gaaacccaat     3540

tggaaccaat ctgccccact gtccaaggtg aatggtgaca tgcgtctggt tacaaggaca     3600

gatgggatgg ttgctcctca gagctgggtg tctcgagtat gtgcggtccg ccaaaagatc     3660

ccagattccc tactgctggc cagtactgag taccagccaa gagccgtgtg cctgtccatg     3720

cctgggtcct cagtggaggc cactaaccca cttgtgatgc agttgctgca gggtagcttg     3780

cccctagaga aggttcttcc accagcccac gatgacagca tgtcagaatc cccacaagta     3840

ccacttacaa aagaccagag ccatggctcg ctacgcatgg gatctttaca tggtcttgga     3900

aaaaacagtg gcatggttga tggaagcagc cccagttctt taagggcttt gaaggagcct     3960

cttctgccag atagctgtga aacaggcact ggtcttgcca ggattgaggc cacccaggct     4020

cctggagcac cccaaaagaa ttgcaaggca gtcccaagtt ttgactccct ccatccagtg     4080

acaaatccca ttacatcctc taggaaactg gaagaaatgg attccaaaga gcagttctct     4140

tcctttagtt gtgaagatca gaaggaagtc cgtgctatgt cacaggacag taattcaaat     4200

gctgctccag gaaagagccc aggagatctt actacctcga gaacacctcg tttctcatct     4260

ccaaatgtga tctcctttgg tccagagcag acaggtcggg ccctgggtga tcagagcaat     4320

gttacaggcc aagggaagaa gctttttggc tctgggaatg tggctgcaac ccttcagcgc     4380

cccaggcctg cggacccgat gcctcttcct gctgagatcc ctccagtttt tcccagtggg     4440

aagttgggac caagcacaaa ctccatgtct ggtggggtac agactccaag ggaagactgg     4500

gctccaaagc cacatgcctt tgttggcagc gtcaagaatg agaagacttt tgtggggggt     4560

cctcttaagg caaatgccga gaacaggaaa gctactgggc atagtcccct ggaactggtg     4620

ggtcacttgg aagggatgcc ctttgtcatg gacttgccct tctggaaatt accccgagag     4680

ccagggaagg ggctcagtga gcctctggag ccttcttctc tcccctccca actcagcatc     4740

aagcaggcat tttatgggaa gctttctaaa ctccaactga gttccaccag ctttaattat     4800

tcctctagct ctcccacctt tcccaaaggc cttgctggaa gtgtggtgca gctgagccac     4860

aaagcaaact ttggtgcgag ccacagtgca tcactttcct tgcaaatgtt cactgacagc     4920

agcacggtgg aaagcatctc gctccagtgt gcgtgcagcc tgaaagccat gatcatgtgc     4980

caaggctgcg gtgcgttctg tcacgatgac tgtattggac cctcaaagct ctgtgtattg     5040

tgccttgtgg tgagataata aattatggcc atgggaaaca ttgtatattt agtgtgtgta     5100

ttttgataat gattgatctt aaatctgtat acagaatatc attgatataa tactctttag     5160

gcaggagcac tcttgccttc ccccaaaatt tacactgcta aagccctctg tcacttggcg     5220

acccttctgg tcttgctgga ggggtttcct gggtataacc cattgggctg cccaaggcca     5280

gccagcctga gctctcctgc aagacagagc ctgatgtggc acggagtggg gttgcggggg     5340

gtggggggac tgcctgactc ccagagggac ttgaaactga agcaagaagg ttgcattctc     5400

caccaaggga gttaacctac ctgaactaag tagaaatgcc agtcttccac taccccctcc     5460

ctgccatctt ttcttctgct actttgggga gttgatggcc aggaaagaag ccagcacagg     5520

gttaaagtaa ctcctggcat tgcccaccag ggggctggtg cacctgctga cctcagggtc     5580

acagttgagt catttgccag ttgacggagc aagtttgacc ttggttctgt tgctgaagca     5640

aatttggaac ttttctgtct cagtgtgatc cactaaccca caggatcatt tggaaccttg     5700

aatagctctg cttggacaat ggggttgggg aatagggttg tctttcctat gaaaatgcca     5760

tctgtagacc ttgtgagtca gccgtccaga tgtttgcagg tgaattcctc tgcttgacat     5820

cctccctgtc actttggacc ctatgggagt gggcatctcc acgcacctgt gtatgtgaaa     5880

gtcattttac atttcaaagc agtgtgtgtt tcttattttt atatttttaa ctctttattc     5940

ttggatgtat aaagtgaact ttttggcttc tgtaagtatg ctctatgcac ctctaatgtt     6000

ttatcatgta tttatatgtt gtacacagta ctggctgatt ctgtaaatgg atgtattgta     6060

cagagaacat gaacgtctct tcctaatttt acatcttcag catcattgca ttaaagtggt     6120

gtaatctcct tctctacatc tgttgtcaga gccactgagt gctgtgctgc tcgacgtgag     6180

ggtgaaatga ttgacttgtg acctgccagg ttgcccgatg ccctgttggg tcaccggctg     6240

gacctgctgc agcctgcaga gccacagtca gcctgcccac atgccaccga gcaaacgcat     6300

cttgcttttc acatctctcc tcctacagcc ttaatggctg cttgctgcca tatgtgacaa     6360

atcaccacca ccagtgttaa gtgcttctgg attcatgggt gagttccctg ggcagccccc     6420

aggaaggcct tccagatctg gctccagggt caccacctgt cacagcaata cctgggacca     6480

tgctctcctg ggactgtgag gctccttttg acgtactttt gacatcaggc aggtttggga     6540

agaaacaaag ccatgcctgc tcctgcctct ctcccaacat gtttccagca agtagatgcc     6600

cctgtgtgtg ttttcccttg ccttgtttcc tgccttatat cttgtatttc gacttattac     6660

agagttgagg gttcttgctt aatttagatc aagtataaaa tttgtatgac ttcaagtctc     6720

attttatctg aaaggttttt ttctcattta atctgatgtg gcattttcgt catctgaagc     6780

atgagtgaca agttgggaat gatgtggtga tttagaatgc agtattggcc aagtccaagt     6840

tgtcaactta agcgtctgtt taccaaagac cgggaacagg ggcccaaaca tgtccagtcc     6900

tcttcttccc tctgctggaa cctttgggga cactcaaggg tacagtttga cactgatctg     6960

gtccatgagg ctgcccagag aaagcactgc ttctgtatgt ctcttgtggt attggaacaa     7020

taaacccgta caacctgcaa aaaaaaaaaa aaaaaa                               7056


<210>  24
<211>  1541
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg Thr Trp Ala Glu Ala 
1               5                   10                  15      


Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala Pro Met Thr Pro Lys 
            20                  25                  30          


Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys Glu Met Arg Ser 
        35                  40                  45              


Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser 
    50                  55                  60                  


Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Leu Lys Lys Asp Ala Leu Gln Trp Ser Arg His Pro Ala Thr 
                85                  90                  95      


Val Glu Gly Glu Glu Pro Glu Asp Thr Ala Asp Val Glu Ser Cys Gly 
            100                 105                 110         


Ser Asn Glu Ala Ser Thr Val Ser Gly Glu Asn Asp Val Ser Leu Asp 
        115                 120                 125             


Glu Thr Ser Ser Asn Ala Ser Cys Ser Thr Glu Ser Gln Ser Arg Pro 
    130                 135                 140                 


Leu Ser Asn Pro Arg Asp Ser Tyr Arg Ala Ser Ser Gln Ala Asn Lys 
145                 150                 155                 160 


Gln Lys Lys Lys Thr Gly Val Met Leu Pro Arg Val Val Leu Thr Pro 
                165                 170                 175     


Leu Lys Val Asn Gly Ala His Val Glu Ser Ala Ser Gly Phe Ser Gly 
            180                 185                 190         


Cys His Ala Asp Gly Glu Ser Gly Ser Pro Ser Ser Ser Ser Ser Gly 
        195                 200                 205             


Ser Leu Ala Leu Gly Ser Ala Ala Ile Arg Gly Gln Ala Glu Val Thr 
    210                 215                 220                 


Gln Asp Pro Ala Pro Leu Leu Arg Gly Phe Arg Lys Pro Ala Thr Gly 
225                 230                 235                 240 


Gln Met Lys Arg Asn Arg Gly Glu Glu Ile Asp Phe Glu Thr Pro Gly 
                245                 250                 255     


Ser Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn Ser Arg Thr 
            260                 265                 270         


Phe His Ala Leu Pro Ser His Phe Gln Gln Gln Leu Leu Phe Leu Leu 
        275                 280                 285             


Pro Glu Val Asp Arg Gln Val Gly Thr Asp Gly Leu Leu Arg Leu Ser 
    290                 295                 300                 


Ser Ser Ala Leu Asn Asn Glu Phe Phe Thr His Ala Ala Gln Ser Trp 
305                 310                 315                 320 


Arg Glu Arg Leu Ala Asp Gly Glu Phe Thr His Glu Met Gln Val Arg 
                325                 330                 335     


Ile Arg Gln Glu Met Glu Lys Glu Lys Lys Val Glu Gln Trp Lys Glu 
            340                 345                 350         


Lys Phe Phe Glu Asp Tyr Tyr Gly Gln Lys Leu Gly Leu Thr Lys Glu 
        355                 360                 365             


Glu Ser Leu Gln Gln Asn Val Gly Gln Glu Glu Ala Glu Ile Lys Ser 
    370                 375                 380                 


Gly Leu Cys Val Pro Gly Glu Ser Val Arg Ile Gln Arg Gly Pro Ala 
385                 390                 395                 400 


Thr Arg Gln Arg Asp Gly His Phe Lys Lys Arg Ser Arg Pro Asp Leu 
                405                 410                 415     


Arg Thr Arg Ala Arg Arg Asn Leu Tyr Lys Lys Gln Glu Ser Glu Gln 
            420                 425                 430         


Ala Gly Val Ala Lys Asp Ala Lys Ser Val Ala Ser Asp Val Pro Leu 
        435                 440                 445             


Tyr Lys Asp Gly Glu Ala Lys Thr Asp Pro Ala Gly Leu Ser Ser Pro 
    450                 455                 460                 


His Leu Pro Gly Thr Ser Ser Ala Ala Pro Asp Leu Glu Gly Pro Glu 
465                 470                 475                 480 


Phe Pro Val Glu Ser Val Ala Ser Arg Ile Gln Ala Glu Pro Asp Asn 
                485                 490                 495     


Leu Ala Arg Ala Ser Ala Ser Pro Asp Arg Ile Pro Ser Leu Pro Gln 
            500                 505                 510         


Glu Thr Val Asp Gln Glu Pro Lys Asp Gln Lys Arg Lys Ser Phe Glu 
        515                 520                 525             


Gln Ala Ala Ser Ala Ser Phe Pro Glu Lys Lys Pro Arg Leu Glu Asp 
    530                 535                 540                 


Arg Gln Ser Phe Arg Asn Thr Ile Glu Ser Val His Thr Glu Lys Pro 
545                 550                 555                 560 


Gln Pro Thr Lys Glu Glu Pro Lys Val Pro Pro Ile Arg Ile Gln Leu 
                565                 570                 575     


Ser Arg Ile Lys Pro Pro Trp Val Val Lys Gly Gln Pro Thr Tyr Gln 
            580                 585                 590         


Ile Cys Pro Arg Ile Ile Pro Thr Thr Glu Ser Ser Cys Arg Gly Trp 
        595                 600                 605             


Thr Gly Ala Arg Thr Leu Ala Asp Ile Lys Ala Arg Ala Leu Gln Val 
    610                 615                 620                 


Arg Gly Ala Arg Gly His His Cys His Arg Glu Ala Ala Thr Thr Ala 
625                 630                 635                 640 


Ile Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Ala Thr Asp 
                645                 650                 655     


Glu Gly Gly Gly Arg Gly Ser Ser Ser Gly Asp Gly Gly Glu Ala Cys 
            660                 665                 670         


Gly His Pro Glu Pro Arg Gly Gly Pro Ser Thr Pro Gly Lys Cys Thr 
        675                 680                 685             


Ser Asp Leu Gln Arg Thr Gln Leu Leu Pro Pro Tyr Pro Leu Asn Gly 
    690                 695                 700                 


Glu His Thr Gln Ala Gly Thr Ala Met Ser Arg Ala Arg Arg Glu Asp 
705                 710                 715                 720 


Leu Pro Ser Leu Arg Lys Glu Glu Ser Cys Leu Leu Gln Arg Ala Thr 
                725                 730                 735     


Val Gly Leu Thr Asp Gly Leu Gly Asp Ala Ser Gln Leu Pro Val Ala 
            740                 745                 750         


Pro Thr Gly Asp Gln Pro Cys Gln Ala Leu Pro Leu Leu Ser Ser Gln 
        755                 760                 765             


Thr Ser Val Ala Glu Arg Leu Val Glu Gln Pro Gln Leu His Pro Asp 
    770                 775                 780                 


Val Arg Thr Glu Cys Glu Ser Gly Thr Thr Ser Trp Glu Ser Asp Asp 
785                 790                 795                 800 


Glu Glu Gln Gly Pro Thr Val Pro Ala Asp Asn Gly Pro Ile Pro Ser 
                805                 810                 815     


Leu Val Gly Asp Asp Thr Leu Glu Lys Gly Thr Gly Gln Ala Leu Asp 
            820                 825                 830         


Ser His Pro Thr Met Lys Asp Pro Val Asn Val Thr Pro Ser Ser Thr 
        835                 840                 845             


Pro Glu Ser Ser Pro Thr Asp Cys Leu Gln Asn Arg Ala Phe Asp Asp 
    850                 855                 860                 


Glu Leu Gly Leu Gly Gly Ser Cys Pro Pro Met Arg Glu Ser Asp Thr 
865                 870                 875                 880 


Arg Gln Glu Asn Leu Lys Thr Lys Ala Leu Val Ser Asn Ser Ser Leu 
                885                 890                 895     


His Trp Ile Pro Ile Pro Ser Asn Asp Glu Val Val Lys Gln Pro Lys 
            900                 905                 910         


Pro Glu Ser Arg Glu His Ile Pro Ser Val Glu Pro Gln Val Gly Glu 
        915                 920                 925             


Glu Trp Glu Lys Ala Ala Pro Thr Pro Pro Ala Leu Pro Gly Asp Leu 
    930                 935                 940                 


Thr Ala Glu Glu Gly Leu Asp Pro Leu Asp Ser Leu Thr Ser Leu Trp 
945                 950                 955                 960 


Thr Val Pro Ser Arg Gly Gly Ser Asp Ser Asn Gly Ser Tyr Cys Gln 
                965                 970                 975     


Gln Val Asp Ile Glu Lys Leu Lys Ile Asn Gly Asp Ser Glu Ala Leu 
            980                 985                 990         


Ser Pro His Gly Glu Ser Thr Asp  Thr Ala Ser Asp Phe  Glu Gly His 
        995                 1000                 1005             


Leu Thr  Glu Asp Ser Ser Glu  Ala Asp Thr Arg Glu  Ala Ala Val 
    1010                 1015                 1020             


Thr Lys  Gly Ser Ser Val Asp  Lys Asp Glu Lys Pro  Asn Trp Asn 
    1025                 1030                 1035             


Gln Ser  Ala Pro Leu Ser Lys  Val Asn Gly Asp Met  Arg Leu Val 
    1040                 1045                 1050             


Thr Arg  Thr Asp Gly Met Val  Ala Pro Gln Ser Trp  Val Ser Arg 
    1055                 1060                 1065             


Val Cys  Ala Val Arg Gln Lys  Ile Pro Asp Ser Leu  Leu Leu Ala 
    1070                 1075                 1080             


Ser Thr  Glu Tyr Gln Pro Arg  Ala Val Cys Leu Ser  Met Pro Gly 
    1085                 1090                 1095             


Ser Ser  Val Glu Ala Thr Asn  Pro Leu Val Met Gln  Leu Leu Gln 
    1100                 1105                 1110             


Gly Ser  Leu Pro Leu Glu Lys  Val Leu Pro Pro Ala  His Asp Asp 
    1115                 1120                 1125             


Ser Met  Ser Glu Ser Pro Gln  Val Pro Leu Thr Lys  Asp Gln Ser 
    1130                 1135                 1140             


His Gly  Ser Leu Arg Met Gly  Ser Leu His Gly Leu  Gly Lys Asn 
    1145                 1150                 1155             


Ser Gly  Met Val Asp Gly Ser  Ser Pro Ser Ser Leu  Arg Ala Leu 
    1160                 1165                 1170             


Lys Glu  Pro Leu Leu Pro Asp  Ser Cys Glu Thr Gly  Thr Gly Leu 
    1175                 1180                 1185             


Ala Arg  Ile Glu Ala Thr Gln  Ala Pro Gly Ala Pro  Gln Lys Asn 
    1190                 1195                 1200             


Cys Lys  Ala Val Pro Ser Phe  Asp Ser Leu His Pro  Val Thr Asn 
    1205                 1210                 1215             


Pro Ile  Thr Ser Ser Arg Lys  Leu Glu Glu Met Asp  Ser Lys Glu 
    1220                 1225                 1230             


Gln Phe  Ser Ser Phe Ser Cys  Glu Asp Gln Lys Glu  Val Arg Ala 
    1235                 1240                 1245             


Met Ser  Gln Asp Ser Asn Ser  Asn Ala Ala Pro Gly  Lys Ser Pro 
    1250                 1255                 1260             


Gly Asp  Leu Thr Thr Ser Arg  Thr Pro Arg Phe Ser  Ser Pro Asn 
    1265                 1270                 1275             


Val Ile  Ser Phe Gly Pro Glu  Gln Thr Gly Arg Ala  Leu Gly Asp 
    1280                 1285                 1290             


Gln Ser  Asn Val Thr Gly Gln  Gly Lys Lys Leu Phe  Gly Ser Gly 
    1295                 1300                 1305             


Asn Val  Ala Ala Thr Leu Gln  Arg Pro Arg Pro Ala  Asp Pro Met 
    1310                 1315                 1320             


Pro Leu  Pro Ala Glu Ile Pro  Pro Val Phe Pro Ser  Gly Lys Leu 
    1325                 1330                 1335             


Gly Pro  Ser Thr Asn Ser Met  Ser Gly Gly Val Gln  Thr Pro Arg 
    1340                 1345                 1350             


Glu Asp  Trp Ala Pro Lys Pro  His Ala Phe Val Gly  Ser Val Lys 
    1355                 1360                 1365             


Asn Glu  Lys Thr Phe Val Gly  Gly Pro Leu Lys Ala  Asn Ala Glu 
    1370                 1375                 1380             


Asn Arg  Lys Ala Thr Gly His  Ser Pro Leu Glu Leu  Val Gly His 
    1385                 1390                 1395             


Leu Glu  Gly Met Pro Phe Val  Met Asp Leu Pro Phe  Trp Lys Leu 
    1400                 1405                 1410             


Pro Arg  Glu Pro Gly Lys Gly  Leu Ser Glu Pro Leu  Glu Pro Ser 
    1415                 1420                 1425             


Ser Leu  Pro Ser Gln Leu Ser  Ile Lys Gln Ala Phe  Tyr Gly Lys 
    1430                 1435                 1440             


Leu Ser  Lys Leu Gln Leu Ser  Ser Thr Ser Phe Asn  Tyr Ser Ser 
    1445                 1450                 1455             


Ser Ser  Pro Thr Phe Pro Lys  Gly Leu Ala Gly Ser  Val Val Gln 
    1460                 1465                 1470             


Leu Ser  His Lys Ala Asn Phe  Gly Ala Ser His Ser  Ala Ser Leu 
    1475                 1480                 1485             


Ser Leu  Gln Met Phe Thr Asp  Ser Ser Thr Val Glu  Ser Ile Ser 
    1490                 1495                 1500             


Leu Gln  Cys Ala Cys Ser Leu  Lys Ala Met Ile Met  Cys Gln Gly 
    1505                 1510                 1515             


Cys Gly  Ala Phe Cys His Asp  Asp Cys Ile Gly Pro  Ser Lys Leu 
    1520                 1525                 1530             


Cys Val  Leu Cys Leu Val Val  Arg 
    1535                 1540     


