                         SEQUENCE LISTING

<110>  MiRagen Therapeutics, Inc.
 
<120>  miR-29 Mimics for the Treatment of Ocular Fibrosis

<130>  MIRG-059/02WO 308934-2760

<140>  PCT/US2018/063458
<141>  2018-11-30

<150>  US 62/593,198
<151>  2017-11-30

<150>  US 62/694,936
<151>  2018-07-06

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  1
aacacuguuu acaaaugguc cua                                               23


<210>  2
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a monophosphate moiety

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  fluoro uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<400>  2
uagcaccauu ugaaaucagu guuuu                                             25


<210>  3
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<400>  3
uaaccgauuu cagauggugc uauu                                              24


<210>  4
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl uridine

<400>  4
uaaccguuua cagauggucc ua                                                22


<210>  5
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  5
uaaccguuua cagauggucc ua                                                22


<210>  6
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic first-antisense-guide strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a monophosphate moiety

<400>  6
uagcaccauc ugaaaucggu uauu                                              24


<210>  7
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic first-antisense-guide strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a monophosphate moiety

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  fluoro uridine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<400>  7
uagcaccauc ugaaaucggu uauu                                              24


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<400>  8
aacacugauu ucaaauggug cuauu                                             25


<210>  9
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  9
aacacugauu ucaaauggug cua                                               23


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  10
aacacugauu ucaaauggug cuauu                                             25


<210>  11
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  11
uaaccgauuu cagauggugc uauu                                              24


<210>  12
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  12
uaaccgauuu caaauggugc uauu                                              24


<210>  13
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<400>  13
aacacuguuu acgggugguc cua                                               23


<210>  14
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  14
aacacuguuu acgggugguc cua                                               23


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  ribonucleotide guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  ribonucleotide guanosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  ribonucleotide guanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  ribonucleotide adenosine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  15
aacacuguuu acaaaugguc cuatt                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  ribonucleotide guanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  ribonucleotide adenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  ribonucleotide guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  ribonucleotide guanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  ribonucleotide adenosine

<400>  16
ttaacacugu uuacaaaugg uccua                                             25


<210>  17
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified with a cholesterol conjugate with a 9 carbon 
       linker

<400>  17
aacacuguuu acaaaugguc cua                                               23


<210>  18
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a monophosphate moiety

<400>  18
uagcaccauu ugaaaucagu guuuu                                             25


<210>  19
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  fluoro uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<400>  19
uagcaccauu ugaaaucagu guuuu                                             25


<210>  20
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a monophosphate moiety

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  fluoro uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<400>  20
uagcaccacc cgaaaucagu guuuu                                             25


<210>  21
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand

<400>  21
uagcaccauu ugaaaucagu guuuu                                             25


<210>  22
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<400>  22
uaaccgauuu caaauggugc uauu                                              24


<210>  23
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl uridine

<400>  23
uaaccguuua caaauggucc ua                                                22


<210>  24
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  24
uaaccguuua caaauggucc ua                                                22


<210>  25
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic first-antisense-guide strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a monophosphate moiety

<400>  25
uagcaccauu ugaaaucggu uauu                                              24


<210>  26
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic first-antisense-guide strand


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  modified with a monophosphate moiety

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  fluoro uridine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<400>  26
uagcaccauu ugaaaucggu uauu                                              24


<210>  27
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic first-antisense-guide strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  fluoro uridine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<400>  27
uagcaccauc ugaaaucggu uauu                                              24


<210>  28
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  28
aacacugauu ucaaauggug cua                                               23


<210>  29
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  modified with a cholesterol conjugate with a 6 carbon 
       linker

<400>  29
aacacugauu ucaaauggug cuauu                                             25


<210>  30
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  modified with a cholesterol conjugate with a tetraethylene
       glycol moiety

<400>  30
aacacuguuu acaaaugguc cua                                               23


<210>  31
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  O-methyl uridine

<400>  31
uagcaccauu ugaaaucagu guu                                               23


<210>  32
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  O-methyl guanosine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<400>  32
uagcaccauu ugaaaucagu guuuu                                             25


<210>  33
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  O-methyl cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  O-methyl uridine

<220>
<221>  misc_feature
<222>  (23)..(25)
<223>  joined through phosphorothioate bonds

<400>  33
uagcaccauu ugaaaucagu guuuu                                             25


<210>  34
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  fluoro uridine

<400>  34
uagcaccauu ugaaaucagu guu                                               23


<210>  35
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic first-antisense-guide strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  fluoro cytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  fluoro uridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  fluoro uridine

<220>
<221>  misc_feature
<222>  (22)..(24)
<223>  joined through phosphorothioate bonds

<400>  35
uagcaccauu ugaaaucggu uauu                                              24


<210>  36

<400>  36
000

<210>  37
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<400>  37
uaaccgauuu cagauggugc ua                                                22


<210>  38
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29a mimic first-antisense-guide strand

<400>  38
uagcaccauc ugaaaucggu uauu                                              24


<210>  39
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<400>  39
aacacugauu ucaaauggug cua                                               23


<210>  40
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29b mimic first-antisense-guide strand

<400>  40
uagcaccauu ugaaaucagu guuuu                                             25


<210>  41
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic second-sense-passenger strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  O-methyl uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  O-methyl adenosine

<400>  41
uaaccgauuu caaauggugc ua                                                22


<210>  42
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR-29c mimic first-antisense-guide strand

<400>  42
uagcaccauu ugaaaucggu uauu                                              24


