                         SEQUENCE LISTING

<110>  SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE 
       ACADEMY OF SCIENCES
 
<120>  METHODS AND COMPOSITIONS FOR TNBC STRATIFICATION AND TREATMENT

<130>  179879  1PCWO

<160>  31    

<170>  PatentIn version 3.3

<210>  1
<211>  121
<212>  PRT
<213>  GS2(Homo sapiens)

<400>  1

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Ile Thr 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gly Ile Ile Val Val Ser Asp Pro Val Arg Pro Ser Ile Asn Tyr 
    50                  55                  60                  


Ala Asp Phe Val Asp Gly Arg Phe Ser Val Ser Arg Asp Asn Ile Glu 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Ala Val Thr Ser Asp His Arg Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  129
<212>  PRT
<213>  GS4(Homo sapiens)

<400>  2

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Ile Thr Gly Asp Asn 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Tyr Thr Ala Thr Gly Ser Thr Tyr Tyr Thr Glu Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Ile Leu Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Asp Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Thr Asn Asn Arg Tyr Pro Trp Gly Gly Cys Pro Leu Tyr 
            100                 105                 110         


Glu Asp Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  3
<211>  129
<212>  PRT
<213>  GS5(Homo sapiens)

<400>  3

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Ile Thr Gly Asp Asn 
            20                  25                  30          


Cys Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile His Thr Ala Thr Asp Ser Thr Tyr Tyr Thr Glu Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Ile Leu Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Asp Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Thr Asn Asn Arg Tyr Pro Trp Gly Gly Cys Pro Leu Tyr 
            100                 105                 110         


Glu Asp Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  4
<211>  8
<212>  PRT
<213>  CDR1 of GS2(Homo sapiens)

<400>  4

Gly Ser Thr Phe Ser Ile Thr Thr 
1               5               


<210>  5
<211>  7
<212>  PRT
<213>  CDR2 of GS2(Homo sapiens)

<400>  5

Ile Ile Val Val Ser Asp Pro 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  CDR3 of GS2(Homo sapiens)

<400>  6

Val Thr Ser Asp His Arg Gly Tyr 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  CDR1 of GS4 or GS5(Homo sapiens)

<400>  7

Gly Asp Ile Thr Gly Asp Asn Cys 
1               5               


<210>  8
<211>  7
<212>  PRT
<213>  CDR2 of GS4(Homo sapiens)

<400>  8

Ile Tyr Thr Ala Thr Gly Ser 
1               5           


<210>  9
<211>  7
<212>  PRT
<213>  CDR2 of GS5(Homo sapiens)

<400>  9

Ile His Thr Ala Thr Asp Ser 
1               5           


<210>  10
<211>  20
<212>  PRT
<213>  CDR3 of GS4 or GS5(Homo sapiens)

<400>  10

Pro Thr Asn Asn Arg Tyr Pro Trp Gly Gly Cys Pro Leu Tyr Glu Asp 
1               5                   10                  15      


Ala Tyr Asn Tyr 
            20  


<210>  11
<211>  140
<212>  PRT
<213>  HD13-H, heavy chain(Homo sapiens)

<400>  11

Pro Leu Leu Phe Thr Pro Val Ala Lys Ala Gln Val Gln Leu Val Gln 
1               5                   10                  15      


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
            20                  25                  30          


Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg 
        35                  40                  45              


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile 
    50                  55                  60                  


Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile 
65                  70                  75                  80  


Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
                85                  90                  95      


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr Met Gly Asn Gly 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140 


<210>  12
<211>  160
<212>  PRT
<213>  HD21-H, heavy chain(Homo sapiens)

<400>  12

Glu Asn Lys Val Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu 
1               5                   10                  15      


Leu Phe Thr Pro Val Ala Lys Ala Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala 
        35                  40                  45              


Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly 
65                  70                  75                  80  


Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala 
                85                  90                  95      


Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Ser Ser Gly Trp 
        115                 120                 125             


Tyr Gly Leu Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


<210>  13
<211>  140
<212>  PRT
<213>  HD44-H, heavy chain(Homo sapiens)

<400>  13

Ala Leu Leu Pro Leu Leu Phe Thr Pro Val Ala Lys Ala Gln Val Gln 
1               5                   10                  15      


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
            20                  25                  30          


Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
        35                  40                  45              


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile 
    50                  55                  60                  


Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg 
65                  70                  75                  80  


Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                85                  90                  95      


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
            100                 105                 110         


Ala Val Tyr Tyr Asp Ser Ser Gly His Phe Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140 


<210>  14
<211>  140
<212>  PRT
<213>  HD58-H, heavy chain(Homo sapiens)

<400>  14

Leu Leu Phe Thr Pro Val Ala Lys Ala Gln Val Gln Leu Val Gln Ser 
1               5                   10                  15      


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
            20                  25                  30          


Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe 
    50                  55                  60                  


Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr 
65                  70                  75                  80  


Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg 
                85                  90                  95      


Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Ser Ser Gly Ile Phe 
            100                 105                 110         


Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140 


<210>  15
<211>  160
<212>  PRT
<213>  HD61-H, heavy chain(Homo sapiens)

<400>  15

His Gly Glu Asn Lys Val Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu 
1               5                   10                  15      


Pro Leu Leu Phe Thr Pro Val Ala Lys Ala Gln Val Gln Leu Val Gln 
            20                  25                  30          


Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys 
        35                  40                  45              


Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile 
65                  70                  75                  80  


Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile 
                85                  90                  95      


Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
            100                 105                 110         


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Phe Ser Asn Asp 
        115                 120                 125             


Val Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Met Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


<210>  16
<211>  140
<212>  PRT
<213>  Consensus sequence of heavy chains(Homo sapiens)

<400>  16

Ala Leu Leu Pro Leu Leu Phe Thr Pro Val Ala Lys Ala Gln Val Gln 
1               5                   10                  15      


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys 
            20                  25                  30          


Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
        35                  40                  45              


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile 
    50                  55                  60                  


Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg 
65                  70                  75                  80  


Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu 
                85                  90                  95      


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 
            100                 105                 110         


Tyr Tyr Gly Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140 


<210>  17
<211>  140
<212>  PRT
<213>  HD13-L, light chain(Homo sapiens)

<400>  17

Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met 
1               5                   10                  15      


Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
            20                  25                  30          


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn 
        35                  40                  45              


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu 
    50                  55                  60                  


Ile Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                85                  90                  95      


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Phe Pro 
            100                 105                 110         


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140 


<210>  18
<211>  140
<212>  PRT
<213>  HD21-L, light chain(Homo sapiens)

<400>  18

Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala 
1               5                   10                  15      


Glu Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
            20                  25                  30          


Gln Arg Ala Thr Leu Ala Cys Arg Ala Ser Glu Thr Val Ser Val Asn 
        35                  40                  45              


Tyr Leu Ala Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu 
    50                  55                  60                  


Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Arg Leu Glu 
                85                  90                  95      


Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Tyr Ala Ala Ser Pro 
            100                 105                 110         


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140 


<210>  19
<211>  140
<212>  PRT
<213>  HD44-L, light chain(Homo sapiens)

<400>  19

Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met 
1               5                   10                  15      


Ala Val Ile Trp Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
            20                  25                  30          


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr 
        35                  40                  45              


Ser Ser Asn Asn Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Val Gly 
    50                  55                  60                  


Gln Pro Pro Lys Pro Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu 
                85                  90                  95      


Thr Val Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu 
            100                 105                 110         


Gln Tyr Tyr Arg Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140 


<210>  20
<211>  140
<212>  PRT
<213>  HD58-L, light chain(Homo sapiens)

<400>  20

Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met Ala 
1               5                   10                  15      


Glu Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
            20                  25                  30          


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Asp Ile Ser Thr Trp 
        35                  40                  45              


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
    50                  55                  60                  


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Phe Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
                85                  90                  95      


Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala His Ser Phe Pro Leu 
            100                 105                 110         


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
        115                 120                 125             


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140 


<210>  21
<211>  140
<212>  PRT
<213>  HD61-L, light chain(Homo sapiens)

<400>  21

Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met 
1               5                   10                  15      


Ala Asp Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
            20                  25                  30          


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ser Ser 
        35                  40                  45              


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
    50                  55                  60                  


Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Leu Tyr Thr Tyr 
            100                 105                 110         


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140 


<210>  22
<211>  135
<212>  PRT
<213>  Consensus sequence of light chains(Homo sapiens)

<400>  22

Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln Pro Ala Met 
1               5                   10                  15      


Ala Asp Ile Val Met Thr Gln Ser Pro Thr Leu Ser Leu Ser Val Gly 
            20                  25                  30          


Asp Arg Ala Thr Ile Thr Cys Arg Ala Ser Ser Val Ser Tyr Leu Ala 
        35                  40                  45              


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr Ala 
    50                  55                  60                  


Ser Thr Arg Glu Ser Gly Val Pro Arg Phe Ser Gly Ser Gly Ser Gly 
65                  70                  75                  80  


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
                85                  90                  95      


Thr Tyr Tyr Cys Gln Gln Tyr Ser Phe Pro Leu Thr Phe Gly Gln Gly 
            100                 105                 110         


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Pro Ser Asp Glu 
    130                 135 


<210>  23
<211>  21
<212>  DNA
<213>  hPROCR-shRNA-1(Homo sapiens)

<400>  23
gcagcagctc aatgcctaca a                                               21


<210>  24
<211>  21
<212>  DNA
<213>  hPROCR-shRNA-3(Homo sapiens)

<400>  24
tggcctccaa agacttcata t                                               21


<210>  25
<211>  20
<212>  DNA
<213>  hPROCR activation sgRNA(Homo sapiens)

<400>  25
tcctgccggc gctgactcag                                                 20


<210>  26
<211>  20
<212>  DNA
<213>  hPROCR suppression sgRNA(Homo sapiens)

<400>  26
cagactccgc ccctcccaga                                                 20


<210>  27
<211>  21
<212>  DNA
<213>  shRNA sequences-PROCR(Homo sapiens)

<400>  27
gcagcagctc aatgcctaca a                                               21


<210>  28
<211>  21
<212>  DNA
<213>  shRNA sequences-F2R(Homo sapiens)

<400>  28
cccggtcatt tcttctcagg a                                               21


<210>  29
<211>  21
<212>  DNA
<213>  shRNA sequences-IGF-1R(Homo sapiens)

<400>  29
gcggtgtcca ataactacat t                                               21


<210>  30
<211>  21
<212>  DNA
<213>  shRNA sequences-EGFR(Homo sapiens)

<400>  30
cgcaaagtgt gtaacggaat a                                               21


<210>  31
<211>  20
<212>  DNA
<213>  sgRNAs sequence for PROCR activation(Homo sapiens)

<400>  31
tcctgccggc gctgactcag                                                 20


