                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Ryan, Michael S.
       Martin, Sherrie-Ann P.
       Jones, Morrisa C.
       Stanbro, Justin
       Bhambhani, Akhilesh
       Blue, Jeffrey Thomas
       Pixley, Heidi Joanne
       Green-Trexler, Erin, J. 
       Isopi, Lynne Anne 

 
<120> FORMULATIONS OF DENGUE VIRUS VACCINE COMPOSITIONS  


<130>  24547-WO-PCT

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  395
<212>  PRT
<213>  Dengue 1

<400>  1

Met Arg Cys Val Gly Ile Gly Ser Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asp Lys Pro Thr Leu Asp Ile Glu Leu Leu Lys Thr 
        35                  40                  45              


Glu Val Thr Asn Pro Ala Val Leu Arg Lys Leu Cys Ile Glu Ala Lys 
    50                  55                  60                  


Ile Ser Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Thr Leu Val Glu Glu Gln Asp Ala Asn Phe Val Cys Arg Arg Thr Phe 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Ile Thr Cys Ala Lys Phe Lys Cys Val Thr Lys Leu Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Tyr Glu Asn Leu Lys Tyr Ser Val Ile Val Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Ser Thr Glu His Gly Thr 
145                 150                 155                 160 


Thr Ala Thr Ile Thr Pro Gln Ala Pro Thr Ser Glu Ile Gln Leu Thr 
                165                 170                 175     


Asp Tyr Gly Ala Leu Thr Leu Asp Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Thr Met Lys Glu Lys Ser Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala 
    210                 215                 220                 


Ser Thr Ser Gln Glu Thr Trp Asn Arg Gln Asp Leu Leu Val Thr Phe 
225                 230                 235                 240 


Lys Thr Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Thr 
            260                 265                 270         


Ser Gly Thr Thr Thr Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys 
        275                 280                 285             


Met Asp Lys Leu Thr Leu Lys Gly Met Ser Tyr Val Met Cys Thr Gly 
    290                 295                 300                 


Ser Phe Lys Leu Glu Lys Glu Val Ala Glu Thr Gln His Gly Thr Val 
305                 310                 315                 320 


Leu Val Gln Ile Lys Tyr Glu Gly Thr Asp Ala Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Ser Thr Gln Asp Glu Arg Gly Val Thr Gln Asn Gly Arg Leu Ile 
            340                 345                 350         


Thr Ala Asn Pro Ile Val Thr Asp Lys Glu Lys Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Glu Ser Tyr Ile Val Ile Gly Ala Gly Glu 
    370                 375                 380                 


Lys Ala Leu Lys Leu Ser Trp Phe Lys Lys Gly 
385                 390                 395 


<210>  2
<211>  395
<212>  PRT
<213>  Dengue 2

<400>  2

Met Arg Cys Ile Gly Ile Ser Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ser Trp Val Asp Ile Val Leu Glu His Gly Ser Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Glu Ala Lys Gln Pro Ala Thr Leu Arg Lys Tyr Cys Ile Glu Ala Lys 
    50                  55                  60                  


Leu Thr Asn Thr Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Thr Leu Asn Glu Glu Gln Asp Lys Arg Phe Val Cys Lys His Ser Met 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Ile Val Thr Cys Ala Met Phe Thr Cys Lys Lys Asn Met Glu Gly Lys 
        115                 120                 125             


Ile Val Gln Pro Glu Asn Leu Glu Tyr Thr Val Val Ile Thr Pro His 
    130                 135                 140                 


Ser Gly Glu Glu His Ala Val Gly Asn Asp Thr Gly Lys His Gly Lys 
145                 150                 155                 160 


Glu Val Lys Ile Thr Pro Gln Ser Ser Ile Thr Glu Ala Glu Leu Thr 
                165                 170                 175     


Gly Tyr Gly Thr Val Thr Met Glu Cys Ser Pro Arg Thr Gly Leu Asp 
            180                 185                 190         


Phe Asn Glu Met Val Leu Leu Gln Met Lys Asp Lys Ala Trp Leu Val 
        195                 200                 205             


His Arg Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Leu Pro Gly Ala 
    210                 215                 220                 


Asp Thr Gln Gly Ser Asn Trp Ile Gln Lys Glu Thr Leu Val Thr Phe 
225                 230                 235                 240 


Lys Asn Pro His Ala Lys Lys Gln Asp Val Val Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Met 
            260                 265                 270         


Ser Ser Gly Asn Leu Leu Phe Thr Gly His Leu Lys Cys Arg Leu Arg 
        275                 280                 285             


Met Asp Lys Leu Gln Leu Lys Gly Met Ser Tyr Ser Met Cys Thr Gly 
    290                 295                 300                 


Lys Phe Lys Val Val Lys Glu Ile Ala Glu Thr Gln His Gly Thr Ile 
305                 310                 315                 320 


Val Ile Arg Val Gln Tyr Glu Gly Asp Gly Ser Pro Cys Lys Ile Pro 
                325                 330                 335     


Phe Glu Ile Met Asp Leu Glu Lys Arg His Val Leu Gly Arg Leu Ile 
            340                 345                 350         


Thr Val Asn Pro Ile Val Thr Glu Lys Asp Ser Pro Val Asn Ile Glu 
        355                 360                 365             


Ala Glu Pro Pro Phe Gly Asp Ser Tyr Ile Ile Ile Gly Val Glu Pro 
    370                 375                 380                 


Gly Gln Leu Lys Leu Asp Trp Phe Lys Lys Gly 
385                 390                 395 


<210>  3
<211>  393
<212>  PRT
<213>  Dengue 3

<400>  3

Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Leu Ser 
1               5                   10                  15      


Gly Ala Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Lys Asn Lys Pro Thr Leu Asp Ile Glu Leu Gln Lys Thr 
        35                  40                  45              


Glu Ala Thr Gln Leu Ala Thr Leu Arg Lys Leu Cys Ile Glu Gly Lys 
    50                  55                  60                  


Ile Thr Asn Ile Thr Thr Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala 
65                  70                  75                  80  


Ile Leu Pro Glu Glu Gln Asp Gln Asn Tyr Val Cys Lys His Thr Tyr 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser 
            100                 105                 110         


Leu Val Thr Cys Ala Lys Phe Gln Cys Leu Glu Ser Ile Glu Gly Lys 
        115                 120                 125             


Val Val Gln His Glu Asn Leu Lys Tyr Thr Val Ile Ile Thr Val His 
    130                 135                 140                 


Thr Gly Asp Gln His Gln Val Gly Asn Glu Thr Gln Gly Val Thr Ala 
145                 150                 155                 160 


Glu Ile Thr Pro Gln Ala Ser Thr Val Glu Ala Ile Leu Pro Glu Tyr 
                165                 170                 175     


Gly Thr Leu Gly Leu Glu Cys Ser Pro Arg Thr Gly Leu Asp Phe Asn 
            180                 185                 190         


Glu Met Ile Leu Leu Thr Met Lys Asn Lys Ala Trp Met Val His Arg 
        195                 200                 205             


Gln Trp Phe Phe Asp Leu Pro Leu Pro Trp Thr Ser Gly Ala Thr Thr 
    210                 215                 220                 


Glu Thr Pro Thr Trp Asn Arg Lys Glu Leu Leu Val Thr Phe Lys Asn 
225                 230                 235                 240 


Ala His Ala Lys Lys Gln Glu Val Val Val Leu Gly Ser Gln Glu Gly 
                245                 250                 255     


Ala Met His Thr Ala Leu Thr Gly Ala Thr Glu Ile Gln Asn Ser Gly 
            260                 265                 270         


Gly Thr Ser Ile Phe Ala Gly His Leu Lys Cys Arg Leu Lys Met Asp 
        275                 280                 285             


Lys Leu Glu Leu Lys Gly Met Ser Tyr Ala Met Cys Leu Asn Thr Phe 
    290                 295                 300                 


Val Leu Lys Lys Glu Val Ser Glu Thr Gln His Gly Thr Ile Leu Ile 
305                 310                 315                 320 


Lys Val Glu Tyr Lys Gly Glu Asp Ala Pro Cys Lys Ile Pro Phe Ser 
                325                 330                 335     


Thr Glu Asp Gly Gln Gly Lys Ala His Asn Gly Arg Leu Ile Thr Ala 
            340                 345                 350         


Asn Pro Val Val Thr Lys Lys Glu Glu Pro Val Asn Ile Glu Ala Glu 
        355                 360                 365             


Pro Pro Phe Gly Glu Ser Asn Ile Val Ile Gly Ile Gly Asp Lys Ala 
    370                 375                 380                 


Leu Lys Ile Asn Trp Tyr Lys Lys Gly 
385                 390             


<210>  4
<211>  395
<212>  PRT
<213>  Dengue 4

<400>  4

Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn 
        115                 120                 125             


Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His 
    130                 135                 140                 


Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val 
145                 150                 155                 160 


Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro 
                165                 170                 175     


Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp 
            180                 185                 190         


Phe Asn Glu Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Ala Ala Gly Ala 
    210                 215                 220                 


Asp Thr Ser Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe 
225                 230                 235                 240 


Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Ser Ala Leu Thr Gly Ala Thr Glu Val Asp Ser 
            260                 265                 270         


Gly Asp Gly Asn His Met Tyr Ala Gly His Leu Lys Cys Lys Val Arg 
        275                 280                 285             


Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly 
    290                 295                 300                 


Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr 
305                 310                 315                 320 


Val Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro 
                325                 330                 335     


Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile 
            340                 345                 350         


Ser Ser Thr Pro Phe Ala Glu Tyr Thr Asn Ser Val Thr Asn Ile Glu 
        355                 360                 365             


Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp 
    370                 375                 380                 


Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly 
385                 390                 395 


<210>  5
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEN4-80EZip

<400>  5

Met Arg Cys Val Gly Val Gly Asn Arg Asp Phe Val Glu Gly Val Ser 
1               5                   10                  15      


Gly Gly Ala Trp Val Asp Leu Val Leu Glu His Gly Gly Cys Val Thr 
            20                  25                  30          


Thr Met Ala Gln Gly Lys Pro Thr Leu Asp Phe Glu Leu Ile Lys Thr 
        35                  40                  45              


Thr Ala Lys Glu Val Ala Leu Leu Arg Thr Tyr Cys Ile Glu Ala Ser 
    50                  55                  60                  


Ile Ser Asn Ile Thr Thr Ala Thr Arg Cys Pro Thr Gln Gly Glu Pro 
65                  70                  75                  80  


Tyr Leu Lys Glu Glu Gln Asp Gln Gln Tyr Ile Cys Arg Arg Asp Val 
                85                  90                  95      


Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Gly 
            100                 105                 110         


Val Val Thr Cys Ala Lys Phe Ser Cys Ser Gly Lys Ile Thr Gly Asn 
        115                 120                 125             


Leu Val Gln Ile Glu Asn Leu Glu Tyr Thr Val Val Val Thr Val His 
    130                 135                 140                 


Asn Gly Asp Thr His Ala Val Gly Asn Asp Thr Ser Asn His Gly Val 
145                 150                 155                 160 


Thr Ala Thr Ile Thr Pro Arg Ser Pro Ser Val Glu Val Lys Leu Pro 
                165                 170                 175     


Asp Tyr Gly Glu Leu Thr Leu Asp Cys Glu Pro Arg Ser Gly Ile Asp 
            180                 185                 190         


Phe Asn Glu Met Ile Leu Met Lys Met Lys Lys Lys Thr Trp Leu Val 
        195                 200                 205             


His Lys Gln Trp Phe Leu Asp Leu Pro Leu Pro Trp Ala Ala Gly Ala 
    210                 215                 220                 


Asp Thr Ser Glu Val His Trp Asn Tyr Lys Glu Arg Met Val Thr Phe 
225                 230                 235                 240 


Lys Val Pro His Ala Lys Arg Gln Asp Val Thr Val Leu Gly Ser Gln 
                245                 250                 255     


Glu Gly Ala Met His Ser Ala Leu Thr Gly Ala Thr Glu Val Asp Ser 
            260                 265                 270         


Gly Asp Gly Asn His Met Tyr Ala Gly His Leu Lys Cys Lys Val Arg 
        275                 280                 285             


Met Glu Lys Leu Arg Ile Lys Gly Met Ser Tyr Thr Met Cys Ser Gly 
    290                 295                 300                 


Lys Phe Ser Ile Asp Lys Glu Met Ala Glu Thr Gln His Gly Thr Thr 
305                 310                 315                 320 


Val Val Lys Val Lys Tyr Glu Gly Ala Gly Ala Pro Cys Lys Val Pro 
                325                 330                 335     


Ile Glu Ile Arg Asp Val Asn Lys Glu Lys Val Val Gly Arg Ile Ile 
            340                 345                 350         


Ser Ser Thr Pro Phe Ala Glu Tyr Thr Asn Ser Val Thr Asn Ile Glu 
        355                 360                 365             


Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp 
    370                 375                 380                 


Ser Ala Leu Thr Leu His Trp Phe Arg Lys Gly Gly Gly Gly Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Thr Gly Gly Gly Ser Gly Gly Gly Ser Pro Arg Met Lys 
                405                 410                 415     


Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu 
            420                 425                 430         


Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu Arg Gly Gly 
        435                 440                 445             


Cys Gly Gly 
    450     


<210>  6
<211>  10705
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DENV1

<400>  6
aguuguuagu cuacguggac cgacaagaac aguuucgaau cggaagcuug cuuaacguag       60

uucuaacagu uuuuuauuag agagcagauc ucugaugaac aaccaacgga aaaagacggg      120

ucgaccgucu uucaauaugc ugaaacgcgc gagaaaccgc gugucaacug uuucacaguu      180

ggcgaagaga uucucaaaag gauugcuuuc aggccaagga cccaugaaau uggugauggc      240

uuuuauagca uuccuaagau uucuagccau accuccaaca gcaggaauuu uggcuagaug      300

gggcucauuc aagaagaaug gagcgaucaa aguguuacgg gguuucaaga aagaaaucuc      360

aaacauguug aacauaauga acaggaggaa aagaucugug accaugcucc ucaugcugcu      420

gcccacagcc cuggcguucc aucugaccac ccgaggggga gagccgcaca ugauaguuag      480

caagcaggaa agaggaaaau cacuuuuguu uaagaccucu gcagguguca acaugugcac      540

ccuuauugca auggauuugg gagaguuaug ugaggacaca augaccuaca aaugcccccg      600

gaucacugag acggaaccag augacguuga cuguuggugc aaugccacgg agacaugggu      660

gaccuaugga acauguucuc aaacugguga acaccgacga gacaaacguu ccgucgcacu      720

ggcaccacac guagggcuug gucuagaaac aagaaccgaa acguggaugu ccucugaagg      780

cgcuuggaaa caaauacaaa aaguggagac cugggcucug agacacccag gauucacggu      840

gauagcccuu uuucuagcac augccauagg aacauccauc acccagaaag ggaucauuuu      900

uauuuugcug augcugguaa cuccauccau ggccaugcgg ugcgugggaa uaggcaacag      960

agacuucgug gaaggacugu caggagcuac guggguggau gugguacugg agcauggaag     1020

uugcgucacu accauggcaa aagacaaacc aacacuggac auugaacucu ugaagacgga     1080

ggucacaaac ccugccgucc ugcgcaaacu gugcauugaa gcuaaaauau caaacaccac     1140

caccgauucg agauguccaa cacaaggaga agccacgcug guggaagaac aggacacgaa     1200

cuuugugugu cgacgaacgu ucguggacag aggcuggggc aaugguugug ggcuauucgg     1260

aaaagguagc uuaauaacgu gugcuaaguu uaagugugug acaaaacugg aaggaaagau     1320

aguccaauau gaaaacuuaa aauauucagu gauagucacc guacacacug gagaccagca     1380

ccaaguugga aaugagacca cagaacaugg aacaacugca accauaacac cucaagcucc     1440

cacgucggaa auacagcuga cagacuacgg agcucuaaca uuggauuguu caccuagaac     1500

agggcuagac uuuaaugaga ugguguuguu gacaauggaa aaacgaucgu ggcucgucca     1560

caaacaaugg uuucuagacu uaccacugcc uuggaccucg ggggcuucaa caucccaaga     1620

gacuuggaau agacaagacu ugcuggucac auuuaagaca gcucaugcaa aaaagcagga     1680

aguagucgua cuaggaucac aagaaggagc aaugcacacu gcguugacug gagcgacaga     1740

aauccaaacg ucuggaacga caacaauuuu ugcaggacac cugaaaugca gacuaaaaau     1800

ggauaaacug acuuuaaaag ggaugucaua uguaaugugc acagggucau ucaaguuaga     1860

gaaggaagug gcugagaccc agcauggaac uguucuagug cagguuaaau acgaaggaac     1920

agaugcacca ugcaagaucc ccuucucguc ccaagaugag aagggaguaa cccagaaugg     1980

gagauugaua acagccaacc ccauagucac ugacaaagaa aaaccaguca acauugaagc     2040

ggagccaccu uuuggugaga gcuacauugu gguaggagca ggugaaaaag cuuugaaacu     2100

aagcugguuc aagaagggaa gcaguauagg gaaaauguuu gaagcaacug cccguggagc     2160

acgaaggaug gccauccugg gagacacugc augggacuuc gguucuauag gagggguguu     2220

cacgucugug ggaaaacuga uacaccagau uuuugggacu gcguauggag uuuuguucag     2280

cgguguuucu uggaccauga agauaggaau agggauucug cugacauggc uaggauuaaa     2340

cucaaggagc acgucccuuu caaugacgug uaucgcaguu ggcaugguca cacuguaccu     2400

aggagucaug guucaggcgg acucgggaug uguaaucaac uggaaaggca gagaacucaa     2460

auguggaagc ggcauuuuug ucaccaauga aguccacacc uggacagagc aauauaaauu     2520

ccaggccgac uccccuaaga gacuaucagc ggccauuggg aaggcauggg aggagggugu     2580

guguggaauu cgaucagcca cucgucucga gaacaucaug uggaagcaaa uaucaaauga     2640

auuaaaccac aucuuacuug aaaaugacau gaaauuuaca guggucguag gagacguuag     2700

uggaaucuug gcccaaggaa agaaaaugau uaggccacaa cccauggaac acaaauacuc     2760

guggaaaagc uggggaaaag ccaaaaucau aggagcagau guacagaaua ccaccuucau     2820

caucgacggc ccaaacaccc cagaaugccc ugauaaccaa agagcaugga acauuuggga     2880

aguugaagac uauggauuug gaauuuucac gacaaacaua ugguugaaau ugcgugacuc     2940

cuacacucaa gugugugacc accggcuaau gucagcugcc aucaaggaua gcaaagcagu     3000

ccaugcugac augggguacu ggauagaaag ugaaaagaac gagacuugga aguuggcaag     3060

agccuccuuc auagaaguua agacaugcau cuggccaaaa ucccacacuc uauggagcaa     3120

uggaguccug gaaagugaga ugauaauccc aaagauauau ggaggaccaa uaucucagca     3180

caacuacaga ccaggauauu ucacacaaac agcagggccg uggcacuugg gcaaguuaga     3240

acuagauuuu gauuuaugug aagguaccac uguuguugug gaugaacauu guggaaaucg     3300

aggaccaucu cuuagaacca caacagucac aggaaagaca auccaugaau ggugcuguag     3360

aucuugcacg uuaccccccc uacguuucaa aggagaagac gggugcuggu acggcaugga     3420

aaucagacca gucaaggaga aggaagagaa ccuaguuaag ucaauggucu cugcaggguc     3480

aggagaagug gacaguuuuu cacuaggacu gcuaugcaua ucaauaauga ucgaagaggu     3540

aaugagaucc agauggagca gaaaaaugcu gaugacugga acauuggcug uguuccuccu     3600

ucucacaaug ggacaauuga cauggaauga ucugaucagg cuauguauca ugguuggagc     3660

caacgcuuca gacaagaugg ggaugggaac aacguaccua gcuuugaugg ccacuuucag     3720

aaugagacca auguucgcag ucgggcuacu guuucgcaga uuaacaucua gagaaguucu     3780

ucuucuuaca guuggauuga gucugguggc aucuguagaa cuaccaaauu ccuuagagga     3840

gcuaggggau ggacuugcaa ugggcaucau gauguugaaa uuacugacug auuuucaguc     3900

acaucagcua ugggcuaccu ugcugucuuu aacauuuguc aaaacaacuu uuucauugca     3960

cuaugcaugg aagacaaugg cuaugauacu gucaauugua ucucucuucc cuuuaugccu     4020

guccacgacu ucucaaaaaa caacauggcu uccgguguug cugggaucuc uuggaugcaa     4080

accacuaacc auguuucuua uaacagaaaa caaaaucugg ggaaggaaaa gcuggccucu     4140

caaugaagga auuauggcug uuggaauagu uagcauucuu cuaaguucac uucucaagaa     4200

ugaugugcca cuagcuggcc cacuaauagc uggaggcaug cuaauagcau guuaugucau     4260

aucuggaagc ucggccgauu uaucacugga gaaagcggcu gaggucuccu gggaagaaga     4320

agcagaacac ucuggugccu cacacaacau acuaguggag guccaagaug auggaaccau     4380

gaaaauaaag gaugaagaga gagaugacac acucaccauu cuccucaaag caacucugcu     4440

agcaaucuca gggguauacc caaugucaau accggcgacc cucuuugugu gguauuuuug     4500

gcagaaaaag aaacagagau caggagugcu augggacaca cccagcccuc cagaagugga     4560

aagagcaguc cuugaugaug gcauuuauag aauucuccaa agaggauugu ugggcagguc     4620

ucaaguagga guaggaguuu uucaagaagg cguguuccac acaauguggc acgucaccag     4680

gggagcuguc cucauguacc aagggaagag acuggaacca aguugggcca gugucaaaaa     4740

agacuugauc ucauauggag gagguuggag guuucaagga uccuggaacg cgggagaaga     4800

agugcaggug auugcuguug aaccggggaa gaaccccaaa aauguacaga cagcgccggg     4860

uaccuucaag accccugaag gcgaaguugg agccauagcu cuagacuuua aacccggcac     4920

aucuggaucu ccuaucguga acagagaggg aaaaauagua ggucuuuaug gaaauggagu     4980

ggugacaaca agugguaccu acgucagugc cauagcucaa gcuaaagcau cacaagaagg     5040

gccucuacca gagauugagg acgagguguu uaggaaaaga aacuuaacaa uaauggaccu     5100

acauccagga ucgggaaaaa caagaagaua ccuuccagcc auaguccgug aggccauaaa     5160

aagaaagcug cgcacgcuag ucuuagcucc cacaagaguu gucgcuucug aaauggcaga     5220

ggcgcucaag ggaaugccaa uaagguauca gacaacagca gugaagagug aacacacggg     5280

aaaggagaua guugaccuua ugugucacgc cacuuucacu augcgucucc ugucuccugu     5340

gagaguuccc aauuauaaua ugauuaucau ggaugaagca cauuucaccg auccagccag     5400

cauagcagcc agaggguaua ucucaacccg aguggguaug ggugaagcag cugcgauuuu     5460

caugacagcc acuccccccg gaucggugga ggccuuucca cagagcaaug caguuaucca     5520

agaugaggaa agagacauuc cugaaagauc auggaacuca ggcuaugacu ggaucacuga     5580

uuucccaggu aaaacagucu gguuuguucc aagcaucaaa ucaggaaaug acauugccaa     5640

cuguuuaaga aagaauggga aacggguggu ccaauugagc agaaaaacuu uugacacuga     5700

guaccagaaa acaaaaaaua acgacuggga cuauguuguc acaacagaca uauccgaaau     5760

gggagcaaac uuccgagccg acaggguaau agacccgagg cggugccuga aaccgguaau     5820

acuaaaagau ggcccagagc gugucauucu agccggaccg augccaguga cuguggcuag     5880

cgccgcccag aggagaggaa gaauuggaag gaaccaaaau aaggaaggcg aucaguauau     5940

uuacauggga cagccucuaa aaaaugauga ggaccacgcc cauuggacag aagcaaaaau     6000

gcuccuugac aacauaaaca caccagaagg gauuauccca gcccucuuug agccggagag     6060

agaaaagagu gcagcaauag acggggaaua cagacuacgg ggugaagcga ggaaaacguu     6120

cguggagcuc augagaagag gagaucuacc ugucuggcua uccuacaaag uugccucaga     6180

aggcuuccag uacuccgaca gaagguggug cuuugauggg gaaaggaaca accagguguu     6240

ggaggagaac auggacgugg agaucuggac aaaagaagga gaaagaaaga aacuacgacc     6300

ccgcuggcug gaugccagaa cauacucuga cccacuggcu cugcgcgaau ucaaagaguu     6360

cgcagcagga agaagaagcg ucucagguga ccuaauauua gaaauaggga aacuuccaca     6420

acauuuaacg caaagggccc agaacgccuu ggacaaucug guuauguugc acaacucuga     6480

acaaggagga aaagccuaua gacacgccau ggaagaacua ccagacacca uagaaacguu     6540

aaugcuccua gcuuugauag cugugcugac ugguggagug acguuguucu uccuaucagg     6600

aaggggucua ggaaaaacau ccauuggccu acucugcgug auugccucaa gugcacuguu     6660

auggauggcc aguguggaac cccauuggau agcggccucu aucauacugg aguucuuucu     6720

gaugguguug cuuauuccag agccggacag acagcgcacu ccacaagaca accagcuagc     6780

auacguggug auaggucugu uauucaugau auugacagug gcagccaaug agaugggauu     6840

acuggaaacc acaaagaagg accuggggau uggucaugca gcugcugaaa accaccauca     6900

ugcugcaaug cuggacguag accuacaucc agcuucagcc uggacucucu augcaguggc     6960

cacaacaauu aucacuccca ugaugagaca cacaauugaa aacacaacgg caaauauuuc     7020

ccugacagcu auugcaaacc aggcagcuau auugauggga cuugacaagg gauggccaau     7080

aucaaagaug gacauaggag uuccacuucu cgccuugggg ugcuauucuc aggugaaccc     7140

gcugacgcug acagcggcgg uauuuaugcu aguggcucau uaugccauaa uuggacccgg     7200

acugcaagca aaagcuacua gagaagcuca aaaaaggaca gcagccggaa uaaugaaaaa     7260

cccaacuguc gacgggaucg uugcaauaga uuuggacccu gugguuuacg augcaaaauu     7320

ugaaaaacag cuaggccaaa uaauguuguu gauacuuugc acaucacaga uccuccugau     7380

gcggaccaca ugggccuugu gugaauccau cacacuagcc acuggaccuc ugaccacgcu     7440

uugggaggga ucuccaggaa aauucuggaa caccacgaua gcggugucca uggcaaacau     7500

uuuuagggga aguuaucuag caggagcagg ucuggccuuu ucauuaauga aaucucuagg     7560

aggagguagg agaggcacgg gagcccaagg ggaaacacug ggagaaaaau ggaaaagaca     7620

gcuaaaccaa uugagcaagu cagaauucaa cacuuacaaa aggaguggga uuauagaggu     7680

ggauagaucu gaagccaaag agggguuaaa aagaggagaa acgacuaaac acgcaguguc     7740

gagaggaacg gccaaacuga ggugguuugu ggagaggaac cuugugaaac cagaagggaa     7800

agucauagac cucgguugug gaagaggugg cuggucauau uauugcgcug ggcugaagaa     7860

agucacagaa gugaaaggau acacgaaagg aggaccugga caugaggaac caaucccaau     7920

ggcaaccuau ggauggaacc uaguaaagcu auacuccggg aaagauguau ucuuuacacc     7980

accugagaaa ugugacaccc ucuuguguga uauuggugag uccucuccga acccaacuau     8040

agaagaagga agaacguuac guguucuaaa gaugguggaa ccauggcuca gaggaaacca     8100

auuuugcaua aaaauucuaa aucccuauau gccgagugug guagaaacuu uggagcaaau     8160

gcaaagaaaa cauggaggaa ugcuagugcg aaauccacuc ucaagaaacu ccacucauga     8220

aauguacugg guuucaugug gaacaggaaa cauuguguca gcaguaaaca ugacaucuag     8280

aaugcugcua aaucgauuca caauggcuca caggaagcca acauaugaaa gagacgugga     8340

cuuaggcgcu ggaacaagac auguggcagu agaaccagag guggccaacc uagauaucau     8400

uggccagagg auagagaaua uaaaaaauga acacaaauca acauggcauu augaugagga     8460

caauccauac aaaacauggg ccuaucaugg aucauaugag gucaagccau caggaucagc     8520

cucauccaug gucaauggug uggugagacu gcuaaccaaa ccaugggaug ucauucccau     8580

ggucacacaa auagccauga cugacaccac acccuuugga caacagaggg uguuuaaaga     8640

gaaaguugac acgcguacac caaaagcgaa acgaggcaca gcacaaauua uggaggugac     8700

agccaggugg uuaugggguu uucucucuag aaacaaaaaa cccagaaucu gcacaagaga     8760

ggaguucaca agaaaaguca ggucaaacgc agcuauugga gcaguguucg uugaugaaaa     8820

ucaauggaac ucagcaaaag aggcagugga agaugaacgg uucugggacc uugugcacag     8880

agagagggag cuucauaaac aaggaaaaug ugccacgugu gucuacaaca ugaugggaaa     8940

gagagagaaa aaauuaggag aguucggaaa ggcaaaagga agucgcgcaa uaugguacau     9000

gugguuggga gcgcgcuuuu uagaguuuga agcccuuggu uucaugaaug aagaucacug     9060

guucagcaga gagaauucac ucaguggagu ggaaggagaa ggacuccaca aacuuggaua     9120

cauacucaga gacauaucaa agauuccagg gggaaauaug uaugcagaug acacagccgg     9180

augggacaca agaauaacag aggaugaucu ucagaaugag gccaaaauca cugacaucau     9240

ggaaccugaa caugcccuau uggccacguc aaucuuuaag cuaaccuacc aaaacaaggu     9300

aguaagggug cagagaccag cgaaaaaugg aaccgugaug gaugucauau ccagacguga     9360

ccagagagga aguggacagg uuggaaccua uggcuuaaac accuucacca acauggaggc     9420

ccaacuaaua agacaaaugg agucugaggg aaucuuuuca cccagcgaau uggaaacccc     9480

aaaucuagcc gaaagagucc ucgacugguu gaaaaaacau ggcaccgaga ggcugaaaag     9540

aauggcaauc aguggagaug acuguguggu gaaaccaauu gaugacagau uugcaacagc     9600

cuuaacagcu uugaaugaca ugggaaaggu aagaaaagac auaccgcaau gggaaccuuc     9660

aaaaggaugg aaugauuggc aacaagugcc uuucuguuca caccauuucc accagcugau     9720

uaugaaggau gggagggaga uaguggugcc augccgcaac caagaugaac uuguagguag     9780

ggccagagua ucacaaggcg ccggauggag cuugagagaa acugcaugcc uaggcaaguc     9840

auaugcacaa auguggcagc ugauguacuu ccacaggaga gacuugagau uagcggcuaa     9900

ugcuaucugu ucagccguuc caguugauug ggucccaacc agccguacca ccuggucgau     9960

ccaugcccac caucaaugga ugacaacaga agacauguug ucagugugga auaggguuug    10020

gauagaggaa aacccaugga uggaggacaa gacucaugug uccaguuggg aagacguucc    10080

auaccuagga aaaagggaag aucaauggug uggaucccua auaggcuuaa cagcacgagc    10140

caccugggcc accaacauac aaguggccau aaaccaagug agaaggcuca uugggaauga    10200

gaauuaucua gacuucauga caucaaugaa gagauucaaa aacgagagug aucccgaagg    10260

ggcacucugg uaagccaacu cauucacaaa auaaaggaaa auaaaaaauc aaacaaggca    10320

agaagucagg ccggauuaag ccauagcacg guaagagcua ugcugccugu gagccccguc    10380

caaggacgua aaaugaaguc aggccgaaag ccacgguucg agcaagccgu gcugccugua    10440

gcuccaucgu ggggauguaa aaacccggga ggcugcaaac cauggaagcu guacgcaugg    10500

gguagcagac uagugguuag aggagacccc ucccaagaca caacgcagca gcggggccca    10560

agacuagagg uuagaggaga ccccccgcac aacaacaaac agcauauuga cgcugggaga    10620

gaccagagau ccugcugucu cuacagcauc auuccaggca cagaucggaa gaaaauggaa    10680

uggugcuguu gaaucaacag guucu                                          10705


<210>  7
<211>  10618
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DENV2

<400>  7
aguuguuagu cuguguggac cgacaaggac aguuccaaau cggaagcuug cuuaacacag       60

uucuaacagu uuguuugaau agagagcaga ucucuggaaa aaugaaccaa cgaaaaaagg      120

ugguuagacc accuuucaau augcugaaac gcgagagaaa ccgcguauca accccucaag      180

ggcuggugaa gagauucuca accggacuuu uuucugggaa aggacccuua cggauggugc      240

uagcauucau cacguuuuug cgaguccuuu ccaucccacc aacagcaggg auucugaaga      300

gauggggaca guugaagaaa aauaaggcca ucaagauacu gauuggauuc aggaaggaga      360

uaggccgcau gcugaacauc uugaacggga gaaaaagguc ugcaggcaug aucauuaugc      420

ugauuccaac agugauggcg uuccauuuaa ccacacguaa cggagaacca cacaugaucg      480

ucaguagaca agagaaaggg aaaagucuuc uguuuaaaac agaggauggu gugaacaugu      540

guacccucau ggccauggac cuuggugaau ugugugaaga uacaaucacg uacaaguguc      600

cucuucucag gcagaaugaa ccagaagaca uagauuguug gugcaacucu acguccacau      660

ggguaacuua ugggacgugu accaccacag gagaacacag aagagaaaaa agaucagugg      720

cacucguucc acauguggga augggacugg agacacgaac ugaaacaugg augucaucag      780

aaggggccug gaaacaugcc cagagaauug aaacuuggau cuugagacau ccaggcuuua      840

ccauaauggc agcaauccug gcauacacca uaggaacgac acauuuccaa agagcccuga      900

uuuucaucuu acugacagcu gucgcuccuu caaugacaau gcguugcaua ggaauaucaa      960

auagagacuu uguagaaggg guuucaggag gaagcugggu ugacauaguc uuagaacaug     1020

gaagcugugu gacgacgaug gcaaaaaaca aaccaacauu ggauuuugaa cugauaaaaa     1080

cagaagccaa acaaccugcc acucuaagga aguacuguau agaggcaaag cugaccaaca     1140

caacaacaga aucucgcugc ccaacacaag gagaaccuag ccuaaaugaa gagcaggaca     1200

aaagguucgu cugcaaacac uccauggugg acagaggaug gggaaaugga uguggauuau     1260

uuggaaaagg aggcauugug accugugcua uguucacaug caaaaagaac auggaaggaa     1320

aagucgugca accagaaaac uuggaauaca ccauugugau aacaccucac ucaggggaag     1380

agcaugcagu cggaaaugac acaggaaaac auggcaagga aaucaaaaua acaccacaga     1440

guuccaucac agaagcagag uugacaggcu auggcacugu cacgauggaa ugcuuuccga     1500

gaacgggccu cgacuucaau gagauggugu ugcugcaaau ggaaaauaaa gcuuggcugg     1560

ugcacaggca augguuccua gaccugccgu ugccauggcu gcccggagcg gacacacaag     1620

gaucaaauug gauacagaaa gagacauugg ucacuuucaa aaauccccau gcgaagaaac     1680

aggauguugu uguuuuggga ucccaagaag gggccaugca cacagcacuc acaggggcca     1740

cagaaaucca gaugucauca ggaaacuuac uguucacagg acaucucaag ugcaggcuga     1800

ggauggacaa acuacagcuc aaaggaaugu cauacucuau gugcacagga aaguuuaaag     1860

uugugaagga aauagcagaa acacaacaug gaacaauagu uaucagagua caauaugaag     1920

gggacgguuc uccauguaag aucccuuuug agauaaugga uuuggaaaaa agacauguuu     1980

uaggucgccu gauuacaguc aacccaaucg uaacagaaaa agauagccca gucaacauag     2040

aagcagaacc uccauucgga gacagcuaca ucaucauagg aguagagccg ggacaauuga     2100

agcucaacug guuuaagaaa ggaaguucua ucggccaaau guuugagaca acaaugaggg     2160

gagcgaagag aauggccauu uuaggugaca cagcuuggga uuuuggaucc cugggaggag     2220

uguuuacauc uauaggaaag gcucuccacc aaguuuucgg agcaaucuau ggggcugccu     2280

ucaguggggu cucauggacu augaaaaucc ucauaggagu cauuaucaca uggauaggaa     2340

ugaacucgag gaacacuuca auggcuauga cgugcauagc uguuggagga aucacucugu     2400

uucugggcuu cacaguucaa gcagacaugg guuguguggc gucauggagu gggaaagaau     2460

ugaagugugg aagcggaauu uuugugguug acaacgugca cacuuggaca gaacaguaca     2520

aauuucaacc agagucccca gcgagacuag cgucugcaau auuaaaugcc cacaaagaug     2580

gggucugugg aauuagauca accacgaggc uggaaaaugu cauguggaag caaauaacca     2640

acgagcuaaa cuauguucuc ugggaaggag gacaugaccu cacuguagug gcuggggaug     2700

ugaagggggu guugaccaaa ggcaagagag cacucacacc cccagugagu gaucugaaau     2760

auucauggaa gacaugggga aaagcaaaaa ucuucacccc agaagcaaga aauagcacau     2820

uuuuaauaga cggaccagac accucugaau gccccaauga acgaagagca uggaacucuc     2880

uugaggugga agacuaugga uuuggcaugu ucacgaccaa cauauggaug aaauuccgag     2940

aaggaaguuc agaagugugu gaccacaggu uaaugucagc ugcaauuaaa gaucagaaag     3000

cugugcaugc ugacaugggu uauuggauag agagcucaaa aaaccagacc uggcagauag     3060

agaaagcauc ucuuauugaa gugaaaacau gucuguggcc caagacccac acacugugga     3120

gcaauggagu gcuggaaagc cagaugcuca uuccaaaauc auaugcgggc ccuuuuucac     3180

agcacaauua ccgccagggc uaugccacgc aaaccguggg cccauggcac uuaggcaaau     3240

uagagauaga cuuuggagaa ugccccggaa caacagucac aauucaggag gauugugacc     3300

auagaggccc aucuuugagg accaccacug caucuggaaa acuagucacg caauggugcu     3360

gccgcuccug cacgaugccu cccuuaaggu ucuugggaga agaugggugc ugguauggga     3420

uggagauuag gcccuugagu gaaaaagaag agaacauggu caaaucacag gugacggccg     3480

gacagggcac aucagaaacu uuuucuaugg gucuguugug ccugaccuug uuuguggaag     3540

aaugcuugag gagaagaguc acuaggaaac acaugauauu aguuguggug aucacucuuu     3600

gugcuaucau ccugggaggc cucacaugga uggacuuacu acgagcccuc aucauguugg     3660

gggacacuau gucugguaga auaggaggac agauccaccu agccaucaug gcaguguuca     3720

agaugucacc aggauacgug cugggugugu uuuuaaggaa acucacuuca agagagacag     3780

cacuaauggu aauaggaaug gccaugacaa cggugcuuuc aauuccacau gaccuuaugg     3840

aacucauuga uggaauauca cugggacuaa uuuugcuaaa aauaguaaca caguuugaca     3900

acacccaagu gggaaccuua gcucuuuccu ugacuuucau aagaucaaca augccauugg     3960

ucauggcuug gaggaccauu auggcugugu uguuuguggu cacacucauu ccuuugugca     4020

ggacaagcug ucuucaaaaa cagucucauu ggguagaaau aacagcacuc auccuaggag     4080

cccaagcucu gccaguguac cuaaugacuc uuaugaaagg agccucaaga agaucuuggc     4140

cucuuaacga gggcauaaug gcuguggguu ugguuagucu cuuaggaagc gcucuuuuaa     4200

agaaugaugu cccuuuagcu ggcccaaugg uggcaggagg cuuacuucug gcggcuuacg     4260

ugaugagugg uagcucagca gaucugucac uagagaaggc cgccaacgug cagugggaug     4320

aaauggcaga cauaacaggc ucaagcccaa ucauagaagu gaagcaggau gaagauggcu     4380

cuuucuccau acgggacguc gaggaaacca auaugauaac ccuuuuggug aaacuggcac     4440

ugauaacagu gucaggucuc uaccccuugg caauuccagu cacaaugacc uuaugguaca     4500

uguggcaagu gaaaacacaa agaucaggag cccuguggga cguccccuca cccgcugcca     4560

cuaaaaaagc cgcacugucu gaaggagugu acaggaucau gcaaagaggg uuauucggga     4620

aaacucaggu uggaguaggg auacacaugg aagguguauu ucacacaaug uggcauguaa     4680

caagaggauc agugaucugc cacgagacug ggagauugga gccaucuugg gcugacguca     4740

ggaaugacau gauaucauac ggugggggau ggaggcuugg agacaaaugg gacaaagaag     4800

aagacguuca gguccucgcc auagaaccag gaaaaaaucc uaaacauguc caaacgaaac     4860

cuggccuuuu caagacccua acuggagaaa uuggagcagu aacauuagau uucaaacccg     4920

gaacgucugg uucucccauc aucaacagga aaggaaaagu caucggacuc uauggaaaug     4980

gaguaguuac caaaucaggu gauuacguca gugccauaac gcaagccgaa agaauuggag     5040

agccagauua ugaaguggau gaggacauuu uucgaaagaa aagauuaacu auaauggacu     5100

uacaccccgg agcuggaaag acaaaaagaa uucuuccauc aauagugaga gaagccuuaa     5160

aaaggaggcu acgaacuuug auuuuagcuc ccacgagagu gguggcggcc gagauggaag     5220

aggcccuacg uggacugcca auccguuauc agaccccagc ugugaaauca gaacacacag     5280

gaagagagau uguagaccuc augugucaug caaccuucac aacaagacuu uugucaucaa     5340

ccaggguucc aaauuacaac cuuauaguga uggaugaagc acauuucacc gauccuucua     5400

gugucgcggc uagaggauac aucucgacca ggguggaaau gggagaggca gcagccaucu     5460

ucaugaccgc aaccccuccc ggagcgacag aucccuuucc ccagagcaac agcccaauag     5520

aagacaucga gagggaaauu ccggaaaggu cauggaacac aggguucgac uggauaacag     5580

acuaccaagg gaaaacugug ugguuuguuc ccagcauaaa agcuggaaau gacauugcaa     5640

auuguuugag aaagucggga aagaaaguua uccaguugag uaggaaaacc uuugauacag     5700

aguauccaaa aacgaaacuc acggacuggg acuuuguggu cacuacagac auaucugaaa     5760

ugggggccaa uuuuagagcc gggagaguga uagacccuag aagaugccuc aagccaguua     5820

uccuaccaga ugggccagag agagucauuu uagcaggucc uauuccagug acuccagcaa     5880

gcgcugcuca gagaagaggg cgaauaggaa ggaacccagc acaagaagac gaccaauacg     5940

uuuucuccgg agacccacua aaaaaugaug aagaucaugc ccacuggaca gaagcaaaga     6000

ugcugcuuga caauaucuac accccagaag ggaucauucc aacauuguuu gguccggaaa     6060

gggaaaaaac ccaagccauu gauggagagu uucgccucag aggggaacaa aggaagacuu     6120

uuguggaauu aaugaggaga ggagaccuuc cgguguggcu gagcuauaag guagcuucug     6180

cuggcauuuc uuacaaagau cgggaauggu gcuucacagg ggaaagaaau aaccaaauuu     6240

uagaagaaaa cauggagguu gaaauuugga cuagagaggg agaaaagaaa aagcuaaggc     6300

caagaugguu agaugcacgu guauacgcug accccauggc uuugaaggau uucaaggagu     6360

uugccagugg aaggaagagu auaacucucg acauccuaac agagauugcc aguuugccaa     6420

cuuaccuuuc cucuagggcc aagcucgccc uugauaacau agucaugcuc cacacaacag     6480

aaagaggagg gagggccuau caacacgccc ugaacgaacu uccggaguca cuggaaacac     6540

ucaugcuugu agcuuuacua ggugcuauga cagcaggcau cuuccuguuu uucaugcaag     6600

ggaaaggaau agggaaauug ucaauggguu ugauaaccau ugcgguggcu aguggcuugc     6660

ucuggguagc agaaauucaa ccccagugga uagcggccuc aaucauacua gaguuuuuuc     6720

ucaugguacu guugauaccg gaaccagaaa aacaaaggac cccacaagac aaucaauuga     6780

ucuacgucau auugaccauu cucaccauca uuggucuaau agcagccaac gagauggggc     6840

ugauugaaaa aacaaaaacg gauuuugggu uuuaccaggu aaaaacagaa accaccaucc     6900

ucgaugugga cuugagacca gcuucagcau ggacgcucua ugcaguagcc accacaauuc     6960

ugacucccau gcugagacac accauagaaa acacgucggc caaccuaucu cuagcagcca     7020

uugccaacca ggcagccguc cuaauggggc uuggaaaagg auggccgcuc cacagaaugg     7080

accucggugu gccgcuguua gcaaugggau gcuauucuca agugaaccca auaaccuuga     7140

cagcauccuu agucaugcuu uucgugcacu augcaauaau aggcccagga uugcaggcaa     7200

aagccacaag agaggcccag aaaaggacag cugcugggau caugaaaaau cccacagugg     7260

acgggauaac aguaauagau cuagaaccaa uauccuauga cccaaaauuu gaaaagcaau     7320

uagggcaggu caugcuacua gucuugugug cuggacaacu acucuugaug agaacaacau     7380

gggcuuucug ugaagucuug acuuuggcca caggaccaau cuugaccuug ugggagggca     7440

acccgggaag guuuuggaac acgaccauag ccguauccac cgccaacauu uucaggggaa     7500

guuacuuggc gggagcugga cuggcuuuuu cacucauaaa gaaugcacaa accccuagga     7560

ggggaacugg gaccacagga gagacacugg gagagaagug gaagagacag cuaaacucau     7620

uagacagaaa agaguuugaa gaguauaaaa gaaguggaau acuagaagug gacaggacug     7680

aagccaaguc ugcccugaaa gaugggucua aaaucaagca ugcaguauca agagggucca     7740

guaagaucag auggauuguu gagagaggga ugguaaagcc aaaagggaaa guuguagauc     7800

uuggcugugg gagaggagga uggucuuauu acauggcgac acucaagaac gugacugaag     7860

ugaaagggua uacaaaagga gguccaggac augaagaacc gauucccaug gcuacuuaug     7920

guuggaauuu ggucaaacuc cauucagggg uugacguguu cuacaaaccc acagagcaag     7980

uggacacccu gcucugugau auuggggagu caucuucuaa uccaacaaua gaggaaggaa     8040

gaacauuaag aguuuugaag augguggagc cauggcucuc uucaaaaccu gaauucugca     8100

ucaaaguccu uaaccccuac augccaacag ucauagaaga gcuggagaaa cugcagagaa     8160

aacauggugg gaaccuuguc agaugcccgc uguccaggaa cuccacccau gagauguauu     8220

gggugucagg agcgucggga aacauuguga gcucugugaa cacaacauca aagauguugu     8280

ugaacagguu cacaacaagg cauaggaaac ccacuuauga gaaggacgua gaucuugggg     8340

caggaacgag aagugucucc acugaaacag aaaaaccaga caugacaauc auugggagaa     8400

ggcuucagcg auugcaagaa gagcacaaag aaaccuggca uuaugaucag gaaaacccau     8460

acagaaccug ggcguaucau ggaagcuaug aagcuccuuc gacaggcucu gcauccucca     8520

uggugaacgg ggugguaaaa cugcuaacaa aacccuggga ugugauucca auggugacuc     8580

aguuagccau gacagauaca accccuuuug ggcaacaaag aguguucaaa gagaaggugg     8640

auaccagaac accacaacca aaacccggua cacgaauggu uaugaccacg acagccaauu     8700

ggcugugggc ccuccuugga aagaagaaaa aucccagacu gugcacaagg gaagaguuca     8760

ucucaaaagu uagaucaaac gcagccauag gcgcagucuu ucaggaagaa cagggaugga     8820

caucagccag ugaagcugug aaugacagcc gguuuuggga acugguugac aaagaaaggg     8880

cccuacacca ggaagggaaa ugugaaucgu gugucuauaa caugauggga aaacgugaga     8940

aaaaguuagg agaguuuggc agagccaagg gaagccgagc aaucugguac auguggcugg     9000

gagcgcgguu ucuggaauuu gaagcccugg guuuuuugaa ugaagaucac ugguuuggca     9060

gagaaaauuc auggagugga guggaagggg aaggucugca cagauuggga uauauccugg     9120

aggagauaga caagaaggau ggagaccuaa uguaugcuga ugacacagca ggcugggaca     9180

caagaaucac ugaggaugac cuucaaaaug aggaacugau cacggaacag auggcucccc     9240

accacaagau ccuagccaaa gccauuuuca aacuaaccua ucaaaacaaa guggugaaag     9300

uccucagacc cacaccgcgg ggagcgguga uggauaucau auccaggaaa gaccaaagag     9360

guaguggaca aguuggaaca uaugguuuga acacauucac caacauggaa guucaacuca     9420

uccgccaaau ggaagcugaa ggagucauca cacaagauga caugcagaac ccaaaagggu     9480

ugaaagaaag aguugagaaa uggcugaaag aguguggugu cgacagguua aagaggaugg     9540

caaucagugg agacgauugc guggugaagc cccuagauga gagguuuggc acuucccucc     9600

ucuucuugaa cgacauggga aaggugagga aagacauucc gcagugggaa ccaucuaagg     9660

gauggaaaaa cuggcaagag guuccuuuuu gcucccacca cuuucacaag aucuuuauga     9720

aggauggccg cucacuaguu guuccaugua gaaaccagga ugaacugaua gggagagcca     9780

gaaucucgca gggagcugga uggagcuuaa gagaaacagc cugccugggc aaagcuuacg     9840

cccagaugug gucgcuuaug uacuuccaca gaagggaucu gcguuuagcc uccauggcca     9900

uaugcucagc aguuccaacg gaaugguuuc caacaagcag aacaacaugg ucaauccacg     9960

cucaucacca guggaugacc acugaagaua ugcucaaagu guggaacaga guguggauag    10020

aagacaaccc uaauaugacu gacaagacuc caguccauuc gugggaagau auaccuuacc    10080

uagggaaaag agaggauuug ugguguggau cccugauugg acuuucuucc agagccaccu    10140

gggcgaagaa cauucacacg gccauaaccc aggucaggaa ccugaucgga aaagaggaau    10200

acguggauua caugccagua augaaaagau acagugcucc uucagagagu gaaggaguuc    10260

uguaauuacc aacaacaaac accaaaggcu auugaaguca ggccacuugu gccacgguuu    10320

gagcaaaccg ugcugccugu agcuccgcca auaaugggag gcguaauaau ccccagggag    10380

gccaugcgcc acggaagcug uacgcguggc auauuggacu agcgguuaga ggagaccccu    10440

cccaucacug acaaaacgca gcaaaagggg gcccaagacu agagguuaga ggagaccccc    10500

ccaacacaaa aacagcauau ugacgcuggg aaagaccaga gauccugcug ucucugcaac    10560

aucaauccag gcacagagcg ccgcaagaug gauugguguu guugauccaa cagguucu      10618


<210>  8
<211>  10645
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DENV3

<400>  8
aguuguuagu cuacguggac cgacaagaac aguuucgacu cggaagcuug cuuaacguag       60

uacugacagu uuuuuauuag agagcagauc ucugaugaac aaccaacgga aaaagacggg      120

aaaaccgucu aucaauaugc ugaaacgcgu gagaaaccgu gugucaacug gaucacaguu      180

ggcgaagaga uucucaagag gacugcugaa cggccaagga ccaaugaaau ugguuauggc      240

guucauagcu uuccucagau uucuagccau uccaccgaca gcaggagucu uggcuagaug      300

gggaaccuuu aagaagucgg gggcuauuaa gguccugaga ggcuucaaga aggagaucuc      360

aaacaugcug agcauuauca acagacggaa aaagacaucg cucugucuca ugaugauguu      420

accagcaaca cuugcuuucc acuugacuuc acgagaugga gagccgcgca ugauuguggg      480

gaagaaugaa agaggaaaau cccuacuuuu uaagacagcc ucuggaauca acaugugcac      540

acucauagcc auggauuugg gagagaugug ugaugacacg gucaccuaca aaugcccccu      600

cauuacugaa guggagccug aagacauuga cugcuggugc aaccuuacau cgacaugggu      660

gaccuacgga acgugcaauc aagcuggaga gcacagacgc gacaaaagau cgguggcguu      720

agcuccccau gucggcaugg gacuggacac acgcacccaa accuggaugu cggcugaagg      780

agcuuggaga caggucgaga agguagagac augggccuuu aggcacccag gguucacaau      840

acuagcccua uuucuugccc auuacauagg cacuuccuug acccagaaag ugguuauuuu      900

cauacuacua augcugguca ccccauccau gacaaugaga ugcgugggag uaggaaacag      960

agauuuugug gaaggccuau caggagcuac guggguugac guggugcucg agcacggugg     1020

gugugugacu accauggcua agaacaagcc cacgcuggau auagagcucc agaagaccga     1080

ggccacccaa cuggcgaccc uaaggaaacu auguauugag ggaaaaauua ccaacguaac     1140

aaccgacuca aggugcccca cccaagggga agcgauuuua ccugaggagc aggaccagaa     1200

ccacgugugc aagcacacau acguggacag aggcugggga aacgguugug guuuguuugg     1260

caagggaagc cugguaacau gcgcgaaauu ucaauguuug gaaucaauag agggaaaagu     1320

ggugcagcau gagaaccuca aauacaccgu caucaucaca gugcacacag gagaucaaca     1380

ccagguggga aaugaaacgc agggagucac ggcugagaua acaccccagg caucaaccgu     1440

ugaagccauc uuaccugaau auggaacccu ugggcuagaa ugcucaccac ggacagguuu     1500

agauuucaau gaaaugauuu uguugacaau gaagaacaga gcauggaugg uacauagaca     1560

augguuuuuu gaccuaccuu uaccauggac aucaggagcu acaacagaaa caccaaccug     1620

gaauaagaaa gagcuucuug ugacauucaa aaacgcacau gcaaaaaagc aagaaguagu     1680

gguccuugga ucgcaagagg gagcaaugca cacagcacug acaggagcua cagagaucca     1740

aaccucagga ggcacaagua uuuuugcggg gcacuuaaaa uguagacuca agauggacaa     1800

auuggaacuc aaggggauga gcuaugcaau gugcuugaau gccuuugugu ugaagaaaga     1860

agucuccgaa acgcaacaug ggacaauacu caucaagguu gaguacaaag gggaagaugc     1920

accuugcaag auuccuuucu ccacggagga uggacaaggg aaagcccaca auggcagacu     1980

gaucacagcu aacccagugg ugaccaagaa ggaggagccu gucaauauug aggcagaacc     2040

uccuuuuggg gaaagcaaua uaguaauugg aauuggagac aaagccuuga aaauuaacug     2100

guacaagaag ggaagcucga uugggaagau guucgaggcc acugccagag gugcaaggcg     2160

cauggccauc uugggagaca cagccuggga cuuuggauca guagguggug uuuuaaauuc     2220

auuaggaaaa auggugcacc aaauauuugg aagugcuuac acagcccuau uuaguggagu     2280

cuccuggaua augaaaauug gaauaggugu ccuuuuaacc uggauagggu ugaauucaaa     2340

aaacacuagu augagcuuua gcugcauugu gauaggaauc auuacacucu aucugggagc     2400

cguggugcaa gcugacaugg ggugugucau aaacuggaaa ggcaaagaac ucaaaugugg     2460

aaguggaauu uucgucacua augaggucca caccuggaca gagcaauaca aauuucaagc     2520

agacuccccc aaaagacugg cgacagccau ugcaggcgcu ugggagaaug gagugugcgg     2580

aaucaggucg acaaccagaa uggagaaccu cuuguggaag caaauagcca augaacugaa     2640

cuacauauua ugggaaaaca acaucaaauu aacgguaguu gugggugaua uaauuggggu     2700

cuuagagcaa gggaaaagaa cacuaacacc acaacccaug gaacuaaaau auucauggaa     2760

aacaugggga aaggcgaaga uagugacagc ugaaacacaa aauuccucuu ucauaauaga     2820

ugggccaaac acaccagagu guccaagugc cucaagagca uggaaugugu gggaggugga     2880

agauuacggg uucggagucu ucacaacuaa cauauggcug aaacuccgag agauguacac     2940

ccaacuaugu gaccacaggc uaaugucggc agccguuaag gaugagaggg ccguacacgc     3000

cgacaugggc uauuggauag aaagccaaaa gaauggaagu uggaagcuag aaaaggcauc     3060

ccucauagag guaaaaaccu gcacauggcc aaaaucacac acucuuugga gcaauggugu     3120

gcuagagagu gacaugauca ucccaaagag ucuggcuggu cccauuucgc aacacaacua     3180

caggcccgga uaccacaccc aaacggcagg acccuggcac uuaggaaaau uggagcugga     3240

cuucaacuau ugugaaggaa caacaguugu caucacagaa aauuguggga caagaggccc     3300

aucacugaga acaacaacag ugucagggaa guugauacac gaaugguguu gccgcucgug     3360

uacacuuccu ccccugcgau acaugggaga agacggcugc ugguauggca uggaaauuag     3420

acccauuaau gagaaagaag agaacauggu aaagucuuua gucucagcag ggaguggaaa     3480

gguggauaac uucacaaugg gugucuugug uuuggcaauc cuuuuugaag aggugaugag     3540

aggaaaauuu gggaaaaagc acaugauugc agggguucuc uucacguuug uacuccuucu     3600

cucagggcaa auaacaugga gagacauggc gcacacacuc auaaugauug gguccaacgc     3660

cucugacaga augggaaugg gcgucacuua ccuagcauug auugcaacau uuaaaauuca     3720

gccauuuuug gcuuugggau ucuuccugag gaaacugaca ucuagagaaa auuuauuguu     3780

gggaguuggg uuggccaugg caacaacguu acaacugcca gaggacauug aacaaauggc     3840

gaauggaaua gcuuuagggc ucauggcucu uaaauuaaua acacaauuug aaacauacca     3900

acuauggacg gcauuagucu cccuaaugug uucaaauaca auuuucacgu ugacuguugc     3960

cuggagaaca gccacccuga uuuuggccgg aauuucucuu uugccagugu gccagucuuc     4020

gagcaugagg aaaacagauu ggcucccaau ggcuguggca gcuaugggag uuccaccccu     4080

accacuuuuu auuuucaguu ugaaagauac gcucaaaagg agaagcuggc cacugaauga     4140

gggggugaug gcuguuggac uugugaguau ucuagcuagu ucucuccuua ggaaugacgu     4200

gcccauggcu ggaccauuag uggcuggggg cuugcugaua gcgugcuacg ucauaacugg     4260

cacgucagca gaccucacug uagaaaaagc agcagaugug acaugggagg aagaggcuga     4320

gcaaacagga gugucccaca auuuaaugau cacaguugau gacgauggaa caaugagaau     4380

aaaagaugau gagacugaga acaucuuaac agugcuuuug aaaacagcau uacuaauagu     4440

gucaggcauu uuuccauacu ccauacccgc aacacuguug gucuggcaca cuuggcaaaa     4500

gcaaacccaa agauccggug uccuauggga cguucccagc cccccagaga cacagaaagc     4560

agaacuggaa gaagggguuu auaggaucaa gcagcaagga auuuuuggga aaacccaagu     4620

ggggguugga guacaaaaag aaggaguuuu ccacaccaug uggcacguca caagaggagc     4680

aguguugaca cacaauggga aaagacugga accaaacugg gcuagcguga aaaaagaucu     4740

gauuucauac ggaggaggau ggaaauugag ugcacaaugg caaaaaggag aggaggugca     4800

gguuauugcc guagagccug ggaagaaccc aaagaacuuu caaaccaugc caggcauuuu     4860

ccagacaaca acaggggaga uaggagcgau ugcacuggac uucaagccug gaacuucagg     4920

aucucccauc auaaacagag agggaaaggu acugggauug uauggcaaug gaguggucac     4980

aaagaauggu ggcuauguca guggaauagc acaaacaaau gcagaaccag acggaccgac     5040

accagaguug gaagaagaga uguucaaaaa gcgaaaucua accauaaugg aucuccaucc     5100

cgggucagga aagacgcgga aauaucuucc agcuauuguu agagaggcaa ucaagagacg     5160

cuuaaggacu cuaauuuugg caccaacaag gguaguugca gcugagaugg aagaagcauu     5220

gaaagggcuc ccaauaaggu aucaaacaac ugcaacaaaa ucugaacaca cagggagaga     5280

gauuguugau cuaaugugcc acgcaacguu cacaaugcgu uugcugucac cagucagggu     5340

uccaaacuac aacuugauaa uaauggauga ggcucauuuc acagacccag ccaguauagc     5400

ggcuagaggg uacauaucaa cucguguagg aaugggagag gcagccgcaa uuuucaugac     5460

agccacaccc ccuggaacag cugaugccuu uccucagagc aacgcuccaa uucaagauga     5520

agaaagagac auaccagaac gcucauggaa uucaggcaau gaauggauua ccgacuuugc     5580

cgggaagacg gugugguuug ucccuagcau caaagcugga aaugacauag caaacugcuu     5640

gcggaaaaau ggaaaaaagg ucauucaacu uaguaggaag acuuuugaca cagaauauca     5700

aaagacuaaa cuaaaugauu gggacuuugu ggugacaaca gacauuucag aaaugggagc     5760

caauuucaaa gcagacagag ugaucgaccc aagaagaugu cucaagccag ugauuuugac     5820

agacggaccc gagcgcguga uccuggcggg accaaugcca gucaccguag cgagcgcugc     5880

gcaaaggaga gggagaguug gcaggaaccc acaaaaagaa aaugaccaau acauauucau     5940

gggccagccc cucaauaaug augaagacca ugcucacugg acagaagcaa aaaugcugcu     6000

agacaacauc aacacaccag aagggaucau accagcucuc uuugaaccag aaagggagaa     6060

gucagccgcc auagacggcg aauaccgccu gaagggugag uccaggaaga ccuucgugga     6120

acucaugagg aggggugacc ucccaguuug gcuagcccau aaaguagcau cagaagggau     6180

caaauauaca gauagaaagu gguguuuuga uggagaacgc aacaaucaaa uuuuagagga     6240

gaauauggau guggaaaucu ggacaaagga aggagaaaag aaaaaauuga gaccuaggug     6300

gcuugaugcc cgcacuuauu cagaucccuu agcgcucaag gaauucaagg acuuugcggc     6360

ugguagaaag ucaauugccc uugaucuugu gacagaaaua ggaagagugc cuucacacuu     6420

agcucacaga acgagaaacg cccuggacaa ucuggugaug uugcacacgu cagaacaugg     6480

cgggagggcc uacaggcaug caguggagga acuaccagaa acaauggaaa cacucuuacu     6540

ccugggacuc augauccugu uaacaggugg agcaaugcuu uucuugauau cagguaaagg     6600

gauuggaaag acuucaauag gacucauuug uguagcugcu uccagcggua uguuauggau     6660

ggcugauguc ccacuccaau ggaucgcguc ugccauaguc cuggaguuuu uuaugauggu     6720

guuacuuaua ccagaaccag aaaagcagag aacuccccaa gacaaucaac ucgcauaugu     6780

cgugauaggc auacucacac uggcugcaau aguagcagcc aaugaaaugg gacuguugga     6840

aaccacaaag agagauuuag gaauguccaa agaaccaggu guuguuucuc caaccagcua     6900

uuuggaugug gacuugcacc cagcaucagc cuggacauug uacgcugugg ccacaacagu     6960

aauaacacca auguugagac auaccauaga gaauuccaca gcaaaugugu cccuggcagc     7020

uauagccaac caggcagugg uccugauggg uuuagacaaa ggauggccga uaucgaaaau     7080

ggacuuaggc gugccacuau uggcacuggg uuguuauuca caagugaacc cacuaacucu     7140

cacagcggca guucuccugc uagccacgca uuaugcuauu auagguccag gauugcaggc     7200

aaaagccacu cgugaagcuc aaaaaaggac agcugcugga auaaugaaga auccaacggu     7260

ggaugggaua augacaauag accuagaucc uguaauauac gauccaaaau uugaaaagca     7320

acuaggacag guuaugcucc ugguucugug ugcaguucaa cuuuuguuaa ugagaacauc     7380

augggcuuuu ugugaagcuc uaacccuagc cacaggacca auaacaacac ucugggaagg     7440

aucaccuggg aaguucugga acaccacgau agcuguuucc auggcgaaca ucuuuagagg     7500

gagcuauuua gcaggagcug ggcuugcuuu uucuaucaug aaaucaguug gaacaggaaa     7560

gagagggaca gggucacagg gugaaaccuu gggagaaaag uggaaaaaga aauugaauca     7620

auuaccccgg aaagaguuug accuuuacaa gaaauccgga aucacugaag uggauagaac     7680

agaagccaaa gaaggguuga aaagaggaga aauaacacac caugccgugu ccagaggcag     7740

cgcaaaacuu caaugguucg uggagagaaa cauggucauc cccgaaggaa gagucauaga     7800

cuuaggcugu ggaagaggag gcuggucaua uuauugugca ggacugaaaa aaguuacaga     7860

agugcgagga uacacaaaag gcggcccagg acaugaagaa ccaguaccua ugucuacaua     7920

cggauggaac auagucaagu uaaugagugg aaaggaugug uuuuaucuuc caccugaaaa     7980

gugugauacu cuauugugug acauuggaga aucuucacca agcccaacag uggaagaaag     8040

cagaaccaua agagucuuga agaugguuga accauggcua agaaauaacc aguuuugcau     8100

uaaaguauug aacccuuaca ugccaacugu gauugagcac cuagaaagac uacaaaggaa     8160

acauggagga augcuuguga gaaauccacu cucacgaaac uccacgcacg aaauguacug     8220

gauaucuaau ggcacaggca auaucguuuc uucagucaac augguaucca gauugcuacu     8280

uaacagauuc acaaugacac auaggagacc caccauagag aaagaugugg auuuaggagc     8340

ggggacccga caugucaaug cggaaccaga aacacccaac auggauguca uuggggaaag     8400

aauaagaagg aucaaggagg agcauaguuc aacauggcac uaugaugaug aaaauccuua     8460

uaaaacgugg gcuuaccaug gauccuauga aguuaaggcc acaggcucag ccuccuccau     8520

gauaaaugga gucgugaaac uccucacgaa accaugggau guggugccca uggugacaca     8580

gauggcaaug acggauacaa ccccauucgg ccagcaaagg guuuuuaaag agaaagugga     8640

caccaggaca cccagaccua ugccaggaac aagaaagguu auggagauca cagcggaaug     8700

gcuuuggaga acccugggaa ggaacaaaag acccagauua uguacgagag aggaguucac     8760

aaaaaagguc agaaccaacg cagcuauggg cgccguuuuu acagaggaga accaauggga     8820

cagugcuaga gcugcuguug aggaugaaga auucuggaaa cucguggaca gagaacguga     8880

acuccacaaa uugggcaagu guggaagcug cguuuacaac augaugggca agagagagaa     8940

gaaacuugga gaguuuggca aagcaaaagg caguagagcc auaugguaca ugugguuggg     9000

agccagauac cuugaguucg aagcacucgg auucuuaaau gaagaccauu gguucucgcg     9060

ugaaaacucu uacaguggag uagaaggaga aggacugcac aagcugggau acaucuuaag     9120

agacauuucc aagauacccg gaggagcuau guaugcugau gacacagcug guugggacac     9180

aagaauaaca gaagaugacc ugcacaauga ggaaaaaauc acacagcaaa uggacccuga     9240

acacaggcag uuagcaaacg cuauauucaa gcucacauac caaaacaaag uggucaaagu     9300

ucaacgacca acuccaaagg gcacgguaau ggacaucaua ucuaggaaag accaaagagg     9360

caguggacag gugggaacuu auggucugaa uacauucacc aacauggaag cccaguuaau     9420

cagacaaaug gaaggagaag guguguuguc gaaggcagac cucgagaacc cucaucugcu     9480

agagaagaaa guuacacaau gguuggaaac aaaaggagug gagagguuaa aaagaauggc     9540

caucagcggg gaugauugcg uggugaaacc aauugaugac agguucgcca augcccugcu     9600

ugcccugaau gacaugggaa aaguuaggaa ggacauaccu caauggcagc caucaaaggg     9660

auggcaugau uggcaacagg ucccuuucug cucccaccac uuucaugaau ugaucaugaa     9720

agauggaaga aaguugguag uucccugcag accucaggau gaauuaaucg ggagagcgag     9780

aaucucucaa ggagcaggau ggagccuuag agaaacugca ugccuaggga aagccuacgc     9840

ccaaaugugg acucucaugu acuuucacag aagagaucuu agacuagcau ccaacgccau     9900

auguucagca guaccagucc auuggguccc cacaagcaga acgacguggu cuauucaugc     9960

ucaccaucag uggaugacua cagaagacau gcuuacuguu uggaacaggg uguggauaga    10020

ggauaaucca uggauggaag acaaaacucc agucaaaacc ugggaagaug uuccauaucu    10080

agggaagaga gaagaccaau ggugcggauc acucauuggu cucacuucca gagcaaccug    10140

ggcccagaac auacuuacgg caauccaaca ggugagaagc cuuauaggca augaagaguu    10200

ucuggacuac augccuucga ugaagagauu caggaaggag gaggagucag agggagccau    10260

uugguaaacg uaggaaguga aaaagaggca aacugucagg ccaccuuaag ccacaguacg    10320

gaagaagcug ugcagccugu gagccccguc caaggacguu aaaagaagaa gucaggccca    10380

aaagccacgg uuugagcaaa ccgugcugcc uguggcuccg ucguggggac guaaaaccug    10440

ggaggcugcg acuagcgguu agaggagacc ccucccguga cacaacgcag cagcggggcc    10500

caagacuaga gguuagagga gaccccccgc aaauaaaaac agcauauuga cgcugggaga    10560

gaccagagau ccugcugucu ccucagcauc auuccaggca cagaacgcca gaaaauggaa    10620

uggugcuguu gaaucaacag guucu                                          10645


<210>  9
<211>  10618
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DENV4

<400>  9
aguuguuagu cuguguggac cgacaaggac aguuccaaau cggaagcuug cuuaacacag       60

uucuaacagu uuguuugaau agagagcaga ucucuggaaa aaugaaccaa cgaaaaaagg      120

ugguuagacc accuuucaau augcugaaac gcgagagaaa ccgcguauca accccucaag      180

gguuggugaa gagauucuca accggacuuu uuucugggaa aggacccuua cggauggugc      240

uagcauucau cacguuuuug cgaguccuuu ccaucccacc aacagcaggg auucugaaga      300

gauggggaca guugaagaaa aauaaggcca ucaagauacu gauuggauuc aggaaggaga      360

uaggccgcau gcugaacauc uugaacggga gaaaaagguc aacgauaaca uugcugugcu      420

ugauucccac cguaauggcg uuuucccuca gcacaagaga uggcgaaccc cucaugauag      480

uggcaaaaca ugaaaggggg agaccucucu uguuuaagac aacagagggg aucaacaaau      540

gcacucucau ugccauggac uugggugaaa ugugugagga cacugucacg uauaaaugcc      600

cccuacuggu caauaccgaa ccugaagaca uugauugcug gugcaaccuc acgucuaccu      660

gggucaugua ugggacaugc acccagagcg gagaacggag acgagagaag cgcucaguag      720

cuuuaacacc acauucagga augggauugg aaacaagagc ugagacaugg augucaucgg      780

aaggggcuug gaagcaugcu cagagaguag agagcuggau acucagaaac ccaggauucg      840

cgcucuuggc aggauuuaug gcuuauauga uugggcaaac aggaauccag cgaacugucu      900

ucuuuguccu aaugaugcug gucgccccau ccuacggaau gcgaugcgua ggaguaggaa      960

acagagacuu uguggaagga gucucaggug gagcaugggu cgaccuggug cuagaacaug     1020

gaggaugcgu cacaaccaug gcccagggaa aaccaaccuu ggauuuugaa cugacuaaga     1080

caacagccaa ggaaguggcu cuguuaagaa ccuauugcau ugaagccuca auaucaaaca     1140

uaacuacggc aacaagaugu ccaacgcaag gagagccuua ucugaaagag gaacaggacc     1200

aacaguacau uugccggaga gaugugguag acagagggug gggcaauggc uguggcuugu     1260

uuggaaaagg aggaguugug acaugugcga aguuuucaug uucggggaag auaacaggca     1320

auuuggucca aauugagaac cuugaauaca cagugguugu aacaguccac aauggagaca     1380

cccaugcagu aggaaaugac acauccaauc auggaguuac agccaugaua acucccaggu     1440

caccaucggu ggaagucaaa uugccggacu auggagaacu aacacucgau ugugaaccca     1500

ggucuggaau ugacuuuaau gagaugauuc ugaugaaaau gaaaaagaaa acauggcucg     1560

ugcauaagca augguuuuug gaucugccuc uuccauggac agcaggagca gacacaucag     1620

agguucacug gaauuacaaa gagagaaugg ugacauuuaa gguuccucau gccaagagac     1680

aggaugugac agugcuggga ucucaggaag gagccaugca uucugcccuc gcuggagcca     1740

cagaagugga cuccggugau ggaaaucaca uguuugcagg acaucuuaag ugcaaagucc     1800

guauggagaa auugagaauc aagggaaugu cauacacgau guguucagga aaguuuucaa     1860

uugacaaaga gauggcagaa acacagcaug ggacaacagu ggugaaaguc aaguaugaag     1920

gugcuggagc uccguguaaa guccccauag agauaagaga uguaaacaag gaaaaagugg     1980

uugggcguau caucucaucc accccuuugg cugagaauac caacagugua accaacauag     2040

aauuagaacc ccccuuuggg gacagcuaca uagugauagg uguuggaaac agcgcauuaa     2100

cacuccauug guucaggaaa gggaguucca uuggcaagau guuugagucc acauacagag     2160

gugcaaaacg aauggccauu cuaggugaaa cagcuuggga uuuugguucc guugguggac     2220

uguucacauc auugggaaag gcugugcacc agguuuuugg aaguguguau acaaccaugu     2280

uuggaggagu cucauggaug auuagaaucc uaauuggguu cuuaguguug uggauuggca     2340

cgaacucgag gaacacuuca auggcuauga cgugcauagc uguuggagga aucacucugu     2400

uucugggcuu cacaguucaa gcagacaugg guuguguggc gucauggagu gggaaagaau     2460

ugaagugugg aagcggaauu uuugugguug acaacgugca cacuuggaca gaacaguaca     2520

aauuucaacc agagucccca gcgagacuag cgucugcaau auuaaaugcc cacaaagaug     2580

gggucugugg aauuagauca accacgaggc uggaaaaugu cauguggaag caaauaacca     2640

acgagcuaaa cuauguucuc ugggaaggag gacaugaccu cacuguagug gcuggggaug     2700

ugaagggggu guugaccaaa ggcaagagag cacucacacc cccagugagu gaucugaaau     2760

auucauggaa gacaugggga aaagcaaaaa ucuucacccc agaagcaaga aauagcacau     2820

uuuuaauaga cggaccagac accucugaau gccccaauga acgaagagca uggaacucuc     2880

uugaggugga agacuaugga uuuggcaugu ucacgaccaa cauauggaug aaauuccgag     2940

aaggaaguuc agaagugugu gaccacaggu uaaugucagc ugcaauuaaa gaucagaaag     3000

cugugcaugc ugacaugggu uauuggauag agagcucaaa aaaccagacc uggcagauag     3060

agaaagcauc ucuuauugaa gugaaaacau gucuguggcc caagacccac acacugugga     3120

gcaauggagu gcuggaaagc cagaugcuca uuccaaaauc auaugcgggc ccuuuuucac     3180

agcacaauua ccgccagggc uaugccacgc aaaccguggg cccauggcac uuaggcaaau     3240

uagagauaga cuuuggagaa ugccccggaa caacagucac aauucaggag gauugugacc     3300

auagaggccc aucuuugagg accaccacug caucuggaaa acuagucacg caauggugcu     3360

gccgcuccug cacgaugccu cccuuaaggu ucuugggaga agaugggugc ugguauggga     3420

uggagauuag gcccuugagu gaaaaagaag agaacauggu caaaucacag gugacggccg     3480

gacagggcac aucagaaacu uuuucuaugg gucuguugug ccugaccuug uuuguggaag     3540

aaugcuugag gagaagaguc acuaggaaac acaugauauu aguuguggug aucacucuuu     3600

gugcuaucau ccugggaggc cucacaugga uggacuuacu acgagcccuc aucauguugg     3660

gggacacuau gucugguaga auaggaggac agauccaccu agccaucaug gcaguguuca     3720

agaugucacc aggauacgug cugggugugu uuuuaaggaa acucacuuca agagagacag     3780

cacuaauggu aauaggaaug gccaugacaa cggugcuuuc aauuccacau gaccuuaugg     3840

aacucauuga uggaauauca cugggacuaa uuuugcuaaa aauaguaaca caguuugaca     3900

acacccaagu gggaaccuua gcucuuuccu ugacuuucau aagaucaaca augccauugg     3960

ucauggcuug gaggaccauu auggcugugu uguuuguggu cacacucauu ccuuugugca     4020

ggacaagcug ucuucaaaaa cagucucauu ggguagaaau aacagcacuc auccuaggag     4080

cccaagcucu gccaguguac cuaaugacuc uuaugaaagg agccucaaga agaucuuggc     4140

cucuuaacga gggcauaaug gcuguggguu ugguuagucu cuuaggaagc gcucuuuuaa     4200

agaaugaugu cccuuuagcu ggcccaaugg uggcaggagg cuuacuucug gcggcuuacg     4260

ugaugagugg uagcucagca gaucugucac uagagaaggc cgccaacgug cagugggaug     4320

aaauggcaga cauaacaggc ucaagcccaa ucauagaagu gaagcaggau gaagauggcu     4380

cuuucuccau acgggacguc gaggaaacca auaugauaac ccuuuuggug aaacuggcac     4440

ugauaacagu gucaggucuc uaccccuugg caauuccagu cacaaugacc uuaugguaca     4500

uguggcaagu gaaaacacaa agaucaggag cccuguggga cguccccuca cccgcugcca     4560

cuaaaaaagc cgcacugucu gaaggagugu acaggaucau gcaaagaggg uuauucggga     4620

aaacucaggu uggaguaggg auacacaugg aagguguauu ucacacaaug uggcauguaa     4680

caagaggauc agugaucugc cacgagacug ggagauugga gccaucuugg gcugacguca     4740

ggaaugacau gauaucauac ggugggggau ggaggcuugg agacaaaugg gacaaagaag     4800

aagacguuca gguccucgcc auagaaccag gaaaaaaucc uaaacauguc caaacgaaac     4860

cuggccuuuu caagacccua acuggagaaa uuggagcagu aacauuagau uucaaacccg     4920

gaacgucugg uucucccauc aucaacagga aaggaaaagu caucggacuc uauggaaaug     4980

gaguaguuac caaaucaggu gauuacguca gugccauaac gcaagccgaa agaauuggag     5040

agccagauua ugaaguggau gaggacauuu uucgaaagaa aagauuaacu auaauggacu     5100

uacaccccgg agcuggaaag acaaaaagaa uucuuccauc aauagugaga gaagccuuaa     5160

aaaggaggcu acgaacuuug auuuuagcuc ccacgagagu gguggcggcc gagauggaag     5220

aggcccuacg uggacugcca auccguuauc agaccccagc ugugaaauca gaacacacag     5280

gaagagagau uguagaccuc augugucaug caaccuucac aacaagacuu uugucaucaa     5340

ccaggguucc aaauuacaac cuuauaguga uggaugaagc acauuucacc gauccuucua     5400

gugucgcggc uagaggauac aucucgacca ggguggaaau gggagaggca gcagccaucu     5460

ucaugaccgc aaccccuccc ggagcgacag aucccuuucc ccagagcaac agcccaauag     5520

aagacaucga gagggaaauu ccggaaaggu cauggaacac aggguucgac uggauaacag     5580

acuaccaagg gaaaacugug ugguuuguuc ccagcauaaa agcuggaaau gacauugcaa     5640

auuguuugag aaagucggga aagaaaguua uccaguugag uaggaaaacc uuugauacag     5700

aguauccaaa aacgaaacuc acggacuggg acuuuguggu cacuacagac auaucugaaa     5760

ugggggccaa uuuuagagcc gggagaguga uagacccuag aagaugccuc aagccaguua     5820

uccuaccaga ugggccagag agagucauuu uagcaggucc uauuccagug acuccagcaa     5880

gcgcugcuca gagaagaggg cgaauaggaa ggaacccagc acaagaagac gaccaauacg     5940

uuuucuccgg agacccacua aaaaaugaug aagaucaugc ccacuggaca gaagcaaaga     6000

ugcugcuuga caauaucuac accccagaag ggaucauucc aacauuguuu gguccggaaa     6060

gggaaaaaac ccaagccauu gauggagagu uucgccucag aggggaacaa aggaagacuu     6120

uuguggaauu aaugaggaga ggagaccuuc cgguguggcu gagcuauaag guagcuucug     6180

cuggcauuuc uuacaaagau cgggaauggu gcuucacagg ggaaagaaau aaccaaauuu     6240

uagaagaaaa cauggagguu gaaauuugga cuagagaggg agaaaagaaa aagcuaaggc     6300

caagaugguu agaugcacgu guauacgcug accccauggc uuugaaggau uucaaggagu     6360

uugccagugg aaggaagagu auaacucucg acauccuaac agagauugcc aguuugccaa     6420

cuuaccuuuc cucuagggcc aagcucgccc uugauaacau agucaugcuc cacacaacag     6480

aaagaggagg gagggccuau caacacgccc ugaacgaacu uccggaguca cuggaaacac     6540

ucaugcuugu agcuuuacua ggugcuauga cagcaggcau cuuccuguuu uucaugcaag     6600

ggaaaggaau agggaaauug ucaauggguu ugauaaccau ugcgguggcu aguggcuugc     6660

ucuggguagc agaaauucaa ccccagugga uagcggccuc aaucauacua gaguuuuuuc     6720

ucaugguacu guugauaccg gaaccagaaa aacaaaggac cccacaagac aaucaauuga     6780

ucuacgucau auugaccauu cucaccauca uuggucuaau agcagccaac gagauggggc     6840

ugauugaaaa aacaaaaacg gauuuugggu uuuaccaggu aaaaacagaa accaccaucc     6900

ucgaugugga cuugagacca gcuucagcau ggacgcucua ugcaguagcc accacaauuc     6960

ugacucccau gcugagacac accauagaaa acacgucggc caaccuaucu cuagcagcca     7020

uugccaacca ggcagccguc cuaauggggc uuggaaaagg auggccgcuc cacagaaugg     7080

accucggugu gccgcuguua gcaaugggau gcuauucuca agugaaccca auaaccuuga     7140

cagcauccuu agucaugcuu uucguccauu augcaauaau aggcccagga uugcaggcaa     7200

aagccacaag agaggcccag aaaaggacag cugcugggau caugaaaaau cccacagugg     7260

acgggauaac aguaauagau cuagaaccaa uauccuauga cccaaaauuu gaaaagcaau     7320

uagggcaggu caugcuacua gucuugugug cuggacaacu acucuugaug agaacaacau     7380

gggcuuucug ugaagucuug acuuuggcca caggaccaau cuugaccuug ugggagggca     7440

acccgggaag guuuuggaac acgaccauag ccguauccac cgccaacauu uucaggggaa     7500

guuacuuggc gggagcugga cuggcuuuuu cacucauaaa gaaugcacaa accccuagga     7560

ggggaacugg gaccacagga gagacacugg gagagaagug gaagagacag cuaaacucau     7620

uagacagaaa agaguuugaa gaguauaaaa gaaguggaau acuagaagug gacaggacug     7680

aagccaaguc ugcccugaaa gaugggucua aaaucaagca ugcaguauca agagggucca     7740

guaagaucag auggauuguu gagagaggga ugguaaagcc aaaagggaaa guuguagauc     7800

uuggcugugg gagaggagga uggucuuauu acauggcgac acucaagaac gugacugaag     7860

ugaaagggua uacaaaagga gguccaggac augaagaacc gauucccaug gcuacuuaug     7920

guuggaauuu ggucaaacuc cauucagggg uugacguguu cuacaaaccc acagagcaag     7980

uggacacccu gcucugugau auuggggagu caucuucuaa uccaacaaua gaggaaggaa     8040

gaacauuaag aguuuugaag augguggagc cauggcucuc uucaaaaccu gaauucugca     8100

ucaaaguccu uaaccccuac augccaacag ucauagaaga gcuggagaaa cugcagagaa     8160

aacauggugg gaaccuuguc agaugcccgc uguccaggaa cuccacccau gagauguauu     8220

gggugucagg agcgucggga aacauuguga gcucugugaa cacaacauca aagauguugu     8280

ugaacagguu cacaacaagg cauaggagac ccacuuauga gaaggacgua gaucuugggg     8340

caggaacgag aagugucucc acugaaacag aaaaaccaga caugacaauc auugggagaa     8400

ggcuucagcg auugcaagaa gagcacaaag aaaccuggca uuaugaucag gaaaacccau     8460

acagaaccug ggcguaucau ggaagcuaug aagcuccuuc gacaggcucu gcauccucca     8520

uggugaacgg ggugguaaaa cugcuaacaa aacccuggga ugugauucca auggugacuc     8580

aguuagccau gacagauaca accccuuuug ggcaacaaag aguguucaaa gagaaggugg     8640

auaccagaac accacaacca aaacccggua cacgaauggu uaugaccacg acagccaauu     8700

ggcugugggc ccuccuugga aagaagaaaa aucccagacu gugcacaagg gaagaguuca     8760

ucucaaaagu uagaucaaac gcagccauag gcgcagucuu ucaggaagaa cagggaugga     8820

caucagccag ugaagcugug aaugacagcc gguuuuggga acugguugac aaagaaaggg     8880

cccuacacca ggaagggaaa ugugaaucgu gugucuauaa caugauggga aaacgugaga     8940

aaaaguuagg agaguuuggc agagccaagg gaagccgagc aaucugguac auguggcugg     9000

gagcgcgguu ucuggaauuu gaagcccugg guuuuuugaa ugaagaucac ugguuuggca     9060

gagaaaauuc auggagugga guggaagggg aaggucugca cagauuggga uauauccugg     9120

aggagauaga caagaaggau ggagaccuaa uguaugcuga ugacacagca ggcugggaca     9180

caagaaucac ugaggaugac cuucaaaaug aggaacugau cacggaacag auggcucccc     9240

accacaagau ccuagccaaa gccauuuuca aacuaaccua ucaaaacaaa guggugaaag     9300

uccucagacc cacaccgcgg ggagcgguga uggauaucau auccaggaaa gaccaaagag     9360

guaguggaca aguuggaaca uaugguuuga acacauucac caacauggaa guucaacuca     9420

uccgccaaau ggaagcugaa ggagucauca cacaagauga caugcagaac ccaaaagggu     9480

ugaaagaaag aguugagaaa uggcugaaag aguguggugu cgacagguua aagaggaugg     9540

caaucagugg agacgauugc guggugaagc cccuagauga gagguuuggc acuucccucc     9600

ucuucuugaa cgacauggga aaggugagga aagacauucc gcagugggaa ccaucuaagg     9660

gauggaaaaa cuggcaagag guuccuuuuu gcucccacca cuuucacaag aucuuuauga     9720

aggauggccg cucacuaguu guuccaugua gaaaccagga ugaacugaua gggagagcca     9780

gaaucucgca gggagcugga uggagcuuaa gagaaacagc cugccugggc aaagcuuacg     9840

cccagaugug gucgcuuaug uacuuccaca gaagggaucu gcguuuagcc uccauggcca     9900

uaugcucagc aguuccaacg gaaugguuuc caacaagcag aacaacaugg ucaauccacg     9960

cucaucacca guggaugacc acugaagaua ugcucaaagu guggaacaga guguggauag    10020

aagacaaccc uaauaugacu gacaagacuc caguccauuc gugggaagau auaccuuacc    10080

uagggaaaag agaggauuug ugguguggau cccugauugg acuuucuucc agagccaccu    10140

gggcgaagaa cauucacacg gccauaaccc aggucaggaa ccugaucgga aaagaggaau    10200

acguggauua caugccagua augaaaagau acagugcucc uucagagagu gaaggaguuc    10260

uguaauuacc aacaacaaac accaaaggcu auugaaguca ggccacuugu gccacgguuu    10320

gagcaaaccg ugcugccugu agcuccgcca auaaugggag gcguaauaau ccccagggag    10380

gccaugcgcc acggaagcug uacgcguggc auauuggacu agcgguuaga ggagaccccu    10440

cccaucacug acaaaacgca gcaaaagggg gcccaagacu agagguuaga ggagaccccc    10500

ccaacacaaa aacagcauau ugacgcuggg aaagaccaga gauccugcug ucucugcaac    10560

aucaauccag gcacagagcg ccgcaagaug gauugguguu guugauccaa cagguucu      10618


