                         SEQUENCE LISTING

<110>  CSL Limited
 
<120>  Use of a FXIIa-inhibitor in the treatment of renal fibrosis and/or chronic kidney disease	

<130>  2017_P003_A274

<150>  EP 17207595.4
<151>  2017-12-15

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of wild-type Infestin-4

<400>  1

Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn Tyr Val Pro Val Cys 
1               5                   10                  15      


Gly Ser Asp Gly Lys Thr Tyr Gly Asn Pro Cys Met Leu Asn Cys Ala 
            20                  25                  30          


Ala Gln Thr Lys Val Pro Gly Leu Lys Leu Val His Glu Gly Arg Cys 
        35                  40                  45              


<210>  2
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of wild-type SPINK-1

<400>  2

Asp Ser Leu Gly Arg Glu Ala Lys Cys Tyr Asn Glu Leu Asn Gly Cys 
1               5                   10                  15      


Thr Lys Ile Tyr Asp Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Pro 
            20                  25                  30          


Asn Glu Cys Val Leu Cys Phe Glu Asn Arg Lys Arg Gln Thr Ser Ile 
        35                  40                  45              


Leu Ile Gln Lys Ser Gly Pro Cys 
    50                  55      


<210>  3
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINK-1 mutant K1

<400>  3

Asp Ser Leu Gly Arg Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn 
1               5                   10                  15      


Tyr Val Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Pro Asn Glu Cys 
            20                  25                  30          


Val Leu Cys Phe Glu Asn Arg Lys Arg Gln Thr Ser Ile Leu Ile Gln 
        35                  40                  45              


Lys Ser Gly Pro Cys 
    50              


<210>  4
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINK-1 mutant K2

<400>  4

Asp Ser Leu Gly Arg Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn 
1               5                   10                  15      


Tyr Val Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Gly Asn Glu Cys 
            20                  25                  30          


Met Leu Cys Ala Glu Asn Arg Lys Arg Gln Thr Ser Ile Leu Ile Gln 
        35                  40                  45              


Lys Glu Gly Pro Cys 
    50              


<210>  5
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPINK-1 mutant K3

<400>  5

Asp Ser Leu Gly Arg Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn 
1               5                   10                  15      


Tyr Val Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Gly Asn Glu Cys 
            20                  25                  30          


Met Leu Asn Cys Ala Glu Asn Arg Lys Arg Gln Thr Ser Ile Leu Ile 
        35                  40                  45              


Gln Lys Glu Gly Pro Cys 
    50                  


<210>  6
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VH of an anti-FXII antibody

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  7
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VL of an anti-FXII antibody

<400>  7

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VH CDR1 of an anti-FXII antibody

<400>  8

Lys Tyr Ile Met Gln 
1               5   


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VH CDR2 of an anti-FXII antibody

<400>  9

Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VH CDR2 of an anti-FXII antibody


<220>
<221>  X
<222>  (3)..(3)
<223>  R or N or D

<220>
<221>  X
<222>  (4)..(4)
<223>  P or V or I or M

<220>
<221>  X
<222>  (5)..(5)
<223>  S or P or A

<220>
<221>  X
<222>  (6)..(6)
<223>  G or L or V or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  X
<222>  (8)..(8)
<223>  G or S

<400>  10

Gly Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VH CDR3 of an anti-FXII antibody

<400>  11

Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VH CDR3 of an anti-FXII antibody


<220>
<221>  X
<222>  (9)..(9)
<223>  I or M or V

<220>
<221>  X
<222>  (10)..(10)
<223>  S or K

<220>
<221>  X
<222>  (11)..(11)
<223>  P or K or T or H

<220>
<221>  X
<222>  (12)..(12)
<223>  H or N or G or Q

<400>  12

Ala Leu Pro Arg Ser Gly Tyr Leu Xaa Xaa Xaa Xaa Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VL CDR1 of an anti-FXII antibody

<400>  13

Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Tyr Val Tyr 
1               5                   10              


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VL CDR2 of an anti-FXII antibody

<400>  14

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VL CDR3 of an anti-FXII antibody

<400>  15

Ala Ala Trp Asp Ala Ser Leu Arg Gly Val 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VL CDR3 of an anti-FXII antibody


<220>
<221>  X
<222>  (2)..(2)
<223>  A or S

<220>
<221>  X
<222>  (4)..(4)
<223>  D or Y or E or T or W or S

<220>
<221>  X
<222>  (5)..(5)
<223>  A or N or I or L or V or P or Q or E

<220>
<221>  X
<222>  (6)..(6)
<223>  S or D or P or E or Q or R

<220>
<221>  X
<222>  (7)..(7)
<223>  L or V

<220>
<221>  X
<222>  (9)..(9)
<223>  G or L or K

<220>
<221>  X
<222>  (10)..(10)
<223>  V or A or D or T or M or G

<400>  16

Ala Xaa Trp Xaa Xaa Xaa Xaa Arg Xaa Xaa 
1               5                   10  


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence from a VL CDR1 of an anti-FXII antibody

<400>  17

Ser Gly Ser Ser Glu Met Thr Val His His Tyr Val Tyr 
1               5                   10              


<210>  18
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence from the VH of anti-FXII antibody gVR115

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Ile Pro Thr Lys Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  19
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence from the VL of anti-FXII antibody gVR115

<400>  19

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  20
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence from the heavy chain of anti-FXII antibody gVR115

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Ile Pro Thr Lys Gly Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
    130                 135                 140                 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
        195                 200                 205             


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455     


<210>  21
<211>  215
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence from the light chain of anti-FXII antibody gVR115

<400>  21

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  22
<211>  615
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence of a human Factor XII

<400>  22

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  23
<211>  609
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence of a mature form of human albumin

<400>  23

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of an Infestin-4 variant

<400>  24

Val Arg Asn Pro Cys Ala Cys Phe Arg Asn Tyr Val 
1               5                   10          


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of an Infestin-4 variant

<400>  25

Asp Ser Leu Gly Arg Glu Val Arg Asn Pro Cys Ala 
1               5                   10          


