                         SEQUENCE LISTING

<110>  Universit de Strasbourg et al
 
<120>  PEPTIDES FOR TREATMENT AND PREVENTION OF NONALCOHOLIC FATTY LIVER
        DISEASE AND FIBROSIS

<130>  B2637PC

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Val Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210>  2
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  2

Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met 
1               5                   10                  15      


Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys Ile Leu 
            20                  25                  30          


Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr Met Val 
        35                  40                  45              


Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu Thr Gln 
    50                  55                  60                  


Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val Met Glu 
65                  70                  75                  80  


Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val Gly Lys 
                85                  90                  95      


Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser Ile Gly 
            100                 105                 110         


Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu 
        115                 120                 125             


Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala Asp Phe 
    130                 135                 140                 


Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg Thr Phe 
145                 150                 155                 160 


Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr Gln Pro 
                165                 170                 175     


Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu Tyr Glu 
            180                 185                 190         


Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp Glu Leu 
        195                 200                 205             


Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser Leu Ser 
    210                 215                 220                 


Lys Glu Ala Val Ser Val Cys Lys Gly Leu Met Thr Lys His Pro Ala 
225                 230                 235                 240 


Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg Glu His 
                245                 250                 255     


Ala 
    


<210>  3
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  segment of kinase domain of alphaPKC

<400>  3

Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala 
1               5                   10          


<210>  4
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  segment of kinase domain of alphaPKC

<400>  4

Leu Met Tyr His Ile Gln Gln Val 
1               5               


<210>  5
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  segment of kinase domain of alphaPKC

<400>  5

Pro Glu Ile Ile 
1               


<210>  6
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  segment of kinase domain of alphaPKC

<400>  6

Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu Tyr Glu Met Leu Ala 
1               5                   10                  15      


<210>  7
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  segment of kinase domain of alphaPKC

<400>  7

Glu Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu 
1               5                   10          


<210>  8
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  segment of kinase domain of alphaPKC

<400>  8

Gly Glu Arg Asp Val Arg Glu 
1               5           


<210>  9
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except R, M and P

<400>  9

Val Glu Cys Thr Xaa Val Glu Lys Arg Val Leu Ala 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<400>  10

Val Glu Cys Thr Met Val Glu Lys Xaa Val Leu Ala 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<400>  11

Val Glu Cys Thr Xaa Val Glu Lys Xaa Val Leu Ala 
1               5                   10          


<210>  12
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid except M, P and R

<400>  12

Leu Xaa Tyr His Ile Gln Gln Val 
1               5               


<210>  13
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is any amino acid except M, P and R

<400>  13

Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu Tyr Glu Xaa Leu Ala 
1               5                   10                  15      


<210>  14
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is any amino acid except M, P and R

<400>  14

Glu Asp Glu Asp Glu Leu Phe Gln Ser Ile Xaa Glu 
1               5                   10          


<210>  15
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid except M, P and R

<400>  15

Gly Glu Xaa Asp Val Arg Glu 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid except M, P and R

<400>  16

Gly Glu Arg Asp Val Xaa Glu 
1               5           


<210>  17
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid except M, P and R

<400>  17

Gly Glu Xaa Asp Val Xaa Glu 
1               5           


<210>  18
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid except M, P and R

<400>  18

Xaa Glu Ile Ile 
1               


<210>  19
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC

<400>  19

Val Glu Cys Thr Thr Val Glu Lys Glu Val Leu Ala 
1               5                   10          


<210>  20
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  Xaa is any amino acid except M, P and R

<400>  20

Val Glu Cys Thr Xaa Val Glu Lys Xaa Val Leu Ala Leu Leu Asp Lys 
1               5                   10                  15      


Xaa Xaa Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  21
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  Xaa is any amino acid except M, P and R

<400>  21

Val Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys 
1               5                   10                  15      


Xaa Xaa Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  22
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except M, P and R

<400>  22

Val Glu Cys Thr Xaa Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys 
1               5                   10                  15      


Pro Pro Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  23
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<400>  23

Val Glu Cys Thr Met Val Glu Lys Xaa Val Leu Ala Leu Leu Asp Lys 
1               5                   10                  15      


Pro Pro Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  24
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  24

Val Glu Cys Thr Met Xaa Glu Lys Arg Val Leu Ala Xaa 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  25

Val Glu Cys Thr Xaa Xaa Glu Lys Arg Val Leu Ala Xaa 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  26

Val Glu Cys Thr Met Xaa Glu Lys Xaa Val Leu Ala Xaa 
1               5                   10              


<210>  27
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  27

Val Glu Cys Thr Xaa Xaa Glu Lys Xaa Val Leu Ala Xaa 
1               5                   10              


<210>  28
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  Xaa is any amino acid except M, P and R

<400>  28

Val Glu Cys Thr Xaa Xaa Glu Lys Xaa Val Leu Ala Xaa Leu Asp Lys 
1               5                   10                  15      


Xaa Xaa Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  29
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (17)..(18)
<223>  Xaa is any amino acid except M, P and R

<400>  29

Val Glu Cys Thr Met Xaa Glu Lys Arg Val Leu Ala Xaa Leu Asp Lys 
1               5                   10                  15      


Xaa Xaa Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  30
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  30

Val Glu Cys Thr Xaa Xaa Glu Lys Arg Val Leu Ala Xaa Leu Asp Lys 
1               5                   10                  15      


Pro Pro Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  31
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid except M, P and R

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  31

Val Glu Cys Thr Met Xaa Glu Lys Xaa Val Leu Ala Xaa Leu Asp Lys 
1               5                   10                  15      


Pro Pro Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  32
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  mutated segment of kinase domain of alphaPKC

<400>  32

Val Glu Cys Thr Thr Arg Glu Lys Glu Val Leu Ala Ser Leu Asp Lys 
1               5                   10                  15      


Ala Ala Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  33
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  protein transduction domain

<400>  33

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  34
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  protein transduction domain

<400>  34

Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro 
1               5                   10                  15  


<210>  35
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  penetratin peptide

<400>  35

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  36
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  HIV-tat

<400>  36

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  37
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  37
tgctttggtt tctgggactt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>   primer

<400>  38
gctctagccg aacacgaatc                                                   20


<210>  39
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  39
tggacaaagt agacggagtg tc                                                22


<210>  40
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  40
tagcaaggcc tgtcccatac                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  41
tgagaacttg ccaccgtatg                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  42
ggcaggtagg cccctatatc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  43
gtttcatccg ggtcttcatc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  44
gtgtctgtgc cctcgaaaat                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  45
aagttctctg cctcccgatt                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  46
caaagcgttg ctggaagttt                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  47
tcgattccct cctacactgc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  48
ttggtggtac tggctcatca                                                   20


<210>  49
<211>  25
<212>  PRT
<213>  ARTIFICIAL

<220>
<223>  Stapled peptide sequence A


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  49

Val Glu Cys Thr Met Xaa Glu Lys Arg Val Leu Ala Xaa Leu Asp Lys 
1               5                   10                  15      


Pro Pro Phe Leu Thr Gln Leu His Ser 
            20                  25  


<210>  50
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Stapled peptide sequence B


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is any amino acid derivative suitable for stapling

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is any amino acid derivative suitable for stapling

<400>  50

Ser Xaa Cys Lys Gly Leu Met Thr Xaa His Pro Ala Lys Arg Leu Gly 
1               5                   10                  15      


Cys Gly Pro Glu Gly 
            20      


<210>  51
<211>  26
<212>  PRT
<213>  artificial

<220>
<223>  Scrambled peptide sequence A

<400>  51

Lys Glu Val Pro Val Asp Thr Cys His Leu Thr Leu Met Leu Leu Phe 
1               5                   10                  15      


Arg Ser Val Ala Leu Lys Gln His Pro Glu 
            20                  25      


<210>  52
<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Scrambled peptide sequence B

<400>  52

Ser Ala Glu Cys Lys Gly Arg His Gly Thr Pro Pro Gly Lys Leu Met 
1               5                   10                  15      


Ile Cys Lys Gly Leu 
            20      


