                         SEQUENCE LISTING

<110>  Koninklijke Philips N.V.
 
<120>  PRE-SURGICAL RISK STRATIFICATION BASED ON PDE4D7 EXPRESSION
       AND PRE-SURGICAL CLINICAL VARIABLES  

<130>  2017PF02734

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  7801
<212>  DNA
<213>  Homo sapiens

<400>  1
gtggtggccg cgcacccggc cgcggctgat tcattcactt caagtgccgt gcagaaggct       60

cggcaggcgg ggcgggcgtg gggccgcggc tccgggttgg ggaccgagga gatccggctg      120

tggaccagac gctcctctgc ggggcgggca cccaagcgcg ctcgccaccc cctcgccatc      180

cgctagagcc gggctcctgg actgggactc gggcccgccg cacagttgaa aagtcgcata      240

gtggtttttc cgctcgcgtc gctgtgtgaa agttggctcg ccgctctttg cacgccctcc      300

ctggaggccg acccgagacg ccaagctgga gagaccgtgc ctccccgagg ccggccgccc      360

cgcgagcaca gcctccgccc ccgttgcact gccgggctgg gcaatatgaa ggagcagccc      420

tcatgtgccg gcaccgggca tccgagcatg gcggggtatg gcaggatggc cccctttgaa      480

ctcgctagcg gacccgtgaa gcgcttgaga actgagtccc cctttccctg tctcttcgca      540

gaggaggcct accagaaact ggccagcgag accctggagg agctggactg gtgtctggac      600

cagctagaga ccctacagac caggcactcc gtcagtgaga tggcctccaa caagtttaaa      660

aggatgctta atcgggagct cacccatctc tctgaaatga gtcggtctgg aaatcaagtg      720

tcagagttta tatcaaacac attcttagat aagcaacatg aagtggaaat tccttctcca      780

actcagaagg aaaaggagaa aaagaaaaga ccaatgtctc agatcagtgg agtcaagaaa      840

ttgatgcaca gctctagtct gactaattca agtatcccaa ggtttggagt taaaactgaa      900

caagaagatg tccttgccaa ggaactagaa gatgtgaaca aatggggtct tcatgttttc      960

agaatagcag agttgtctgg taaccggccc ttgactgtta tcatgcacac catttttcag     1020

gaacgggatt tattaaaaac atttaaaatt ccagtagata ctttaattac atatcttatg     1080

actctcgaag accattacca tgctgatgtg gcctatcaca acaatatcca tgctgcagat     1140

gttgtccagt ctactcatgt gctattatct acacctgctt tggaggctgt gtttacagat     1200

ttggagattc ttgcagcaat ttttgccagt gcaatacatg atgtagatca tcctggtgtg     1260

tccaatcaat ttctgatcaa tacaaactct gaacttgcct tgatgtacaa tgattcctca     1320

gtcttagaga accatcattt ggctgtgggc tttaaattgc ttcaggaaga aaactgtgac     1380

attttccaga atttgaccaa aaaacaaaga caatctttaa ggaaaatggt cattgacatc     1440

gtacttgcaa cagatatgtc aaaacacatg aatctactgg ctgatttgaa gactatggtt     1500

gaaactaaga aagtgacaag ctctggagtt cttcttcttg ataattattc cgataggatt     1560

caggttcttc agaatatggt gcactgtgca gatctgagca acccaacaaa gcctctccag     1620

ctgtaccgcc agtggacgga ccggataatg gaggagttct tccgccaagg agaccgagag     1680

agggaacgtg gcatggagat aagccccatg tgtgacaagc acaatgcttc cgtggaaaaa     1740

tcacaggtgg gcttcataga ctatattgtt catcccctct gggagacatg ggcagacctc     1800

gtccaccctg acgcccagga tattttggac actttggagg acaatcgtga atggtaccag     1860

agcacaatcc ctcagagccc ctctcctgca cctgatgacc cagaggaggg ccggcagggt     1920

caaactgaga aattccagtt tgaactaact ttagaggaag atggtgagtc agacacggaa     1980

aaggacagtg gcagtcaagt ggaagaagac actagctgca gtgactccaa gactctttgt     2040

actcaagact cagagtctac tgaaattccc cttgatgaac aggttgaaga ggaggcagta     2100

ggggaagaag aggaaagcca gcctgaagcc tgtgtcatag atgatcgttc tcctgacacg     2160

taacagtgca aaaactttca tgcctttttt ttttttaagt agaaaaattg tttccaaagt     2220

gcatgtcaca tgccacaacc acggtcacac ctcactgtca tctgccagga cgtttgttga     2280

acaaaactga ccttgactac tcagtccagc gctcaggaat atcgtaacca gttttttcac     2340

ctccatgtca tccgagcaag gtggacatct tcacgaacag cgtttttaac aagatttcag     2400

cttggtagag ctgacaaagc agataaaatc tactccaaat tattttcaag agagtgtgac     2460

tcatcaggca gcccaaaagt ttattggact tggggtttct attccttttt atttgtttgc     2520

aatattttca gaagaaaggc attgcacaga gtgaacttaa tggacgaagc aacaaatatg     2580

tcaagaacag gacatagcac gaatctgtta ccagtaggag gaggatgagc cacagaaatt     2640

gcataatttt ctaatttcaa gtcttcctga tacatgactg aatagtgtgg ttcagtgagc     2700

tgcactgacc tctacatttt gtatgatatg taaaacagat tttttgtaga gcttactttt     2760

attattaaat gtattgaggt attatattta aaaaaaacta tgttcagaac ttcatctgcc     2820

actggttatt tttttctaag gagtaacttg caagttttca gtacaaatct gtgctacact     2880

ggataaaaat ctaatttatg aattttactt gcaccttata gttcatagca attaactgat     2940

ttgtagtgat tcattgtttg ttttatatac caatgacttc catattttaa aagagaaaaa     3000

caactttatg ttgcaggaaa ccctttttgt aagtctttat tatttacttt gcattttgtt     3060

tcactctttc cagataagca gagttgctct tcaccagtgt ttttcttcat gtgcaaagtg     3120

actatttgtt ctataatact tttatgtgtg ttatatcaaa tgtgtcttaa gcttcatgca     3180

aactcagtca tcagttcgtg ttgtctgaag caagtgggag atatataaat acccagtagc     3240

taaaatggtc agtctttttt agatgttttc ctacttagta tctcctaata acgttttgct     3300

gtgtcactag atgttcattt cacaagtgca tgtctttcta ataatccaca catttcatgc     3360

tctaataatc cacacatttc atgctcattt ttattgtttt tacagccagt tatagtaaga     3420

aaaaggtttt tccccttgtg ctgctttata atttagcgtg tgtctgaacc ttatccatgt     3480

ttgctagatg aggtcttgtc aaatatatca ctaccattgt caccggtgaa aagaaacagg     3540

tagttaagtt agggttaaca ttcatttcaa ccacgaggtt gtatatcatg actagctttt     3600

actcttggtt tacagagaaa agttaaacag ccaactaggc agtttttaag aatattaaca     3660

atatattaac aaacaccaat acaactaatc ctatttggtt ttaatgattt caccatggga     3720

ttaagaacta tatcaggaac atccctgaga aacggtttta agtgtagcaa ctactcttcc     3780

ttaatggaca gccacataac gtgtaggaag tcctttatca cttatcctcg atccataagc     3840

atatcttgca gaggggaact acttctttaa acacatggag ggaaagaaga tgatgccact     3900

ggcaccagag ggttagtact gtgatgcatc ctaaaatatt tattatattg gtaaaaattc     3960

tggttaaata aaaaattaga gatcactctt ggctgatttc agcaccagga actgtattac     4020

agttttagag attaattcct agtgtttacc tgattatagc agttggcatc atggggcatt     4080

taattctgac tttatcccca cgtcagcctt aataaagtct tctttacctt ctctatgaag     4140

actttaaagc ccaaataatc atttttcaca ttgatattca agaattgaga tagatagaag     4200

ccaaagtggg tatctgacaa gtggaaaatc aaacgtttaa gaagaattac aactctgaaa     4260

agcatttata tgtggaactt ctcaaggagc ctcctgggga ctggaaagta agtcatcagc     4320

caggcaaatg actcatgctg aagagagtcc ccatttcagt cccctgagat ctagctgatg     4380

cttagatcct ttgaaataaa aattatgtct ttataactct gatcttttac ataaagcaga     4440

agaggaatca actagttaat tgcaaggttt ctactctgtt tcctctgtaa agatcagatg     4500

gtaatctttc aaataagaaa aaaataaaga cgtatgtttg accaagtagt ttcacaagaa     4560

tatttgggaa cttgtttctt ttaattttat ttgtccctga gtgaagtcta gaaagaaagg     4620

taaagagtct agagtttatt cctctttcca aaacattctc attcctctcc tccctacact     4680

tagtatttcc cccacagagt gcctagaatc ttaataatga ataaaataaa aagcagcaat     4740

atgtcattaa caaatccaga cctgaaaggg taaagggttt ataactgcac taataaagag     4800

aggctctttt tttttcttcc agtttgttgg tttttaatgg taccgtgttg taaagatacc     4860

cactaatgga caatcaaatt gcagaaaagg ctcaatatcc aagagacagg gactaatgca     4920

ctgtacaatc tgcttatcct tgcccttctc tcttgccaaa gtgtgcttca gaaatatata     4980

ctgctttaaa aaagaataaa agaatatcct tttacaagtg gctttacatt tcctaaaatg     5040

ccataagaaa atgcaatatc tgggtactgt atggggaaaa aaatgtccaa gtttgtgtaa     5100

aaccagtgca tttcagcttg caagttactg aacacaataa tgctgtttta attttgtttt     5160

atatcagtta aaattcacaa taatgtagat agaacaaatt acagacaagg aaagaaaaaa     5220

cttgaatgaa atggatttta cagaaagctt tatgataatt tttgaatgca ttatttattt     5280

tttgtgccat gcattttttt tctcaccaaa tgaccttacc tgtaatacag tcttgtttgt     5340

ctgtttacaa ccatgtattt attgcaatgt acatactgta atgttaattg taaattatct     5400

gttcttatta aaacatcatc ccatgatggg atggtgttga tatatttgga aactcttggt     5460

gagagaatga atggtgtgta tacatactct gtacattttt cttttctcct gtaatatagt     5520

cttgtcacct tagagcttgt ttatggaaga ttcaagaaaa ctataaaata cttaaagata     5580

tataaattta aaaaaacata gctgcaggtc tttggtccca gggctgtgcc ttaactttaa     5640

ccaatatttt cttctgtttt gctgcatttg aaaggtaaca gtggagctag ggctgggcat     5700

tttacatcca ggcttttaat tgattagaat tctgccaata ggtggatttt acaaaaccac     5760

agacaacctc tgaaagattc tgagaccctt ttgagacaga agctcttaag tacttcttgc     5820

cagggagcag cactgcatgt gtgatggttg tttgccatct gttgatcagg aactacttca     5880

gctacttgca tttgattatt tccttttttt ttttttttaa ctcggaaaca caactgggga     5940

aatatattct ttcccagtga ttataaacaa tctttttctt ttttttaagt ccttttggct     6000

tctagagctc ataggaaaat ggacttgatt tgaaattgga gccagagttt actcgtgttg     6060

gttatctatt catcagcttc ctgacatgtt aagagaatac attaaagaga aaatactgtt     6120

ttttaatcct aaaatttttc ttccactaag ataaaccaaa tgtccttaca tatatgtaaa     6180

cccatctatt taaacgcaaa ggtgggttga tgtcagttta catagcagaa agcattcact     6240

atcctctaag atttgtttct gcaaaacttt cattgcttta gaattttaaa atttcacctt     6300

gtacaatggc cagcccctaa agcaggaaac atttataatg gattatatgg aaacatcctc     6360

ccagtacttg cccagccctt gaatcatgtg gcttttcagt gaaaggaaag attctttttc     6420

taggaaaaat gagcctattt tattttattt tattttattt tttgacacaa actgtagatt     6480

ttagcagccc tggcccaaag gaatttgatt acttttgttt taaacagtac aaaggggaca     6540

ctataattac aaaaacatcc ttaactgatt tgagttgttt ttatttcttt ggatatattt     6600

tcagagtggt aaattgtgtg tgagaattac aaatgattat tcttttagtg gtttcttagc     6660

ctctcttaca gcccacgggg atagtactgt acatcaatac cttcatatga aatttttata     6720

tgcaatgaaa ataaaagcat gggttgattc tgcctattta tgactcaatc ttttacaaat     6780

aaaagattat tcattttaaa ttatagttca atcagcatgt ctcttaggat actgaacgtg     6840

gttgaaatga aaggatagtg acatcataag ttagtactga tattcataac caaataaagc     6900

caacttgagt aattttgcta cattaaaaat taccaaaatt acttagatgg cctataagat     6960

taagcatggt gttttctaag caagctttga aaggggcctt ccatacttac ttaattgaat     7020

attctgggat attgaaaatt attcagatac ttgacaatta tttttggtta cctactccgc     7080

aaactacaaa gttttaagga ctcaacaata agttaatgag acacagtgtt tgctttcatg     7140

gagcttacag tctggagggg acaaaggctt aaacaatact catataatta tatatgtgat     7200

cagtacaatg aaggagctca gtggggtaaa taagcaggaa cctgaacttg atctgttccg     7260

gagggccaca gaaggcttcc ttgaggcctt gagaaagtga tttgcatctg agttctgaag     7320

gattgtaaga ggtaactagg gaaaaagttg acaggaagag gaaggggatc cagacaagaa     7380

acatttgcaa agatcttgag gcataaatga gcttgagaca tctggagaaa ctgaggaaaa     7440

gtgagagagt aggcagggcc tggagccgca gagccattgc taaccatcct gtgtgagata     7500

tcccccattc tgtagcttta ttctcataac cctgctcaat tttctttata acacttctca     7560

cagatttata tacgtgtttg tttttgttat ctgtctctcc caccagacca cagctccatg     7620

agagcaaggt ctttgcttac caatatatca ctagcactta aaactatgcc tggtacacag     7680

taggttctta atatgtgttg aatatagcca tcaaattgat attggatata attcaatctg     7740

ataagatatt ttgagatatt aaagagtttt taacttgata ccataaaaaa aaaaaaaaaa     7800

a                                                                     7801


<210>  2
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Glu Gln Pro Ser Cys Ala Gly Thr Gly His Pro Ser Met Ala 
1               5                   10                  15      


Gly Tyr Gly Arg Met Ala Pro Phe Glu Leu Ala Ser Gly Pro Val Lys 
            20                  25                  30          


Arg Leu Arg Thr Glu Ser Pro Phe Pro Cys Leu Phe Ala Glu Glu Ala 
        35                  40                  45              


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
    50                  55                  60                  


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
65                  70                  75                  80  


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
                85                  90                  95      


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
            100                 105                 110         


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
        115                 120                 125             


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
    130                 135                 140                 


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
145                 150                 155                 160 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
                165                 170                 175     


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
            180                 185                 190         


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
        195                 200                 205             


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
    210                 215                 220                 


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
225                 230                 235                 240 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
                245                 250                 255     


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
            260                 265                 270         


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
        275                 280                 285             


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
    290                 295                 300                 


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
305                 310                 315                 320 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
                325                 330                 335     


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
            340                 345                 350         


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
        355                 360                 365             


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
    370                 375                 380                 


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
385                 390                 395                 400 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
                405                 410                 415     


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
            420                 425                 430         


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
        435                 440                 445             


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
    450                 455                 460                 


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
465                 470                 475                 480 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
                485                 490                 495     


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
            500                 505                 510         


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
        515                 520                 525             


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
    530                 535                 540                 


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
545                 550                 555                 560 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
                565                 570                 575     


Val Ile Asp Asp Arg Ser Pro Asp Thr 
            580                 585 


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D1D2_forward primer

<400>  3
aatatgaagg agcagccctc a                                                 21


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D1D2_reverse primer

<400>  4
gtctcgctgg ccagtttc                                                     18


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D1D2 probe

<400>  5
catccgagca tggcggga                                                     18


<210>  6
<211>  7715
<212>  DNA
<213>  Homo sapiens

<400>  6
gtggtggccg cgcacccggc cgcggctgat tcattcactt caagtgccgt gcagaaggct       60

cggcaggcgg ggcgggcgtg gggccgcggc tccgggttgg ggaccgagga gatccggctg      120

tggaccagac gctcctctgc ggggcgggca cccaagcgcg ctcgccaccc cctcgccatc      180

cgctagagcc gggctcctgg actgggactc gggcccgccg cacagttgaa aagtcgcata      240

gtggtttttc cgctcgcgtc gctgtgtgaa agttggctcg ccgctctttg cacgccctcc      300

ctggaggccg acccgagacg ccaagctgga gagaccgtgc ctccccgagg ccggccgccc      360

cgcgagcaca gcctccgccc ccgttgcact gccgggctgg gcaatatgaa ggagcagccc      420

tcatgtgccg gcaccgggca tccgagcatg gcgggaggag gcctaccaga aactggccag      480

cgagaccctg gaggagctgg actggtgtct ggaccagcta gagaccctac agaccaggca      540

ctccgtcagt gagatggcct ccaacaagtt taaaaggatg cttaatcggg agctcaccca      600

tctctctgaa atgagtcggt ctggaaatca agtgtcagag tttatatcaa acacattctt      660

agataagcaa catgaagtgg aaattccttc tccaactcag aaggaaaagg agaaaaagaa      720

aagaccaatg tctcagatca gtggagtcaa gaaattgatg cacagctcta gtctgactaa      780

ttcaagtatc ccaaggtttg gagttaaaac tgaacaagaa gatgtccttg ccaaggaact      840

agaagatgtg aacaaatggg gtcttcatgt tttcagaata gcagagttgt ctggtaaccg      900

gcccttgact gttatcatgc acaccatttt tcaggaacgg gatttattaa aaacatttaa      960

aattccagta gatactttaa ttacatatct tatgactctc gaagaccatt accatgctga     1020

tgtggcctat cacaacaata tccatgctgc agatgttgtc cagtctactc atgtgctatt     1080

atctacacct gctttggagg ctgtgtttac agatttggag attcttgcag caatttttgc     1140

cagtgcaata catgatgtag atcatcctgg tgtgtccaat caatttctga tcaatacaaa     1200

ctctgaactt gccttgatgt acaatgattc ctcagtctta gagaaccatc atttggctgt     1260

gggctttaaa ttgcttcagg aagaaaactg tgacattttc cagaatttga ccaaaaaaca     1320

aagacaatct ttaaggaaaa tggtcattga catcgtactt gcaacagata tgtcaaaaca     1380

catgaatcta ctggctgatt tgaagactat ggttgaaact aagaaagtga caagctctgg     1440

agttcttctt cttgataatt attccgatag gattcaggtt cttcagaata tggtgcactg     1500

tgcagatctg agcaacccaa caaagcctct ccagctgtac cgccagtgga cggaccggat     1560

aatggaggag ttcttccgcc aaggagaccg agagagggaa cgtggcatgg agataagccc     1620

catgtgtgac aagcacaatg cttccgtgga aaaatcacag gtgggcttca tagactatat     1680

tgttcatccc ctctgggaga catgggcaga cctcgtccac cctgacgccc aggatatttt     1740

ggacactttg gaggacaatc gtgaatggta ccagagcaca atccctcaga gcccctctcc     1800

tgcacctgat gacccagagg agggccggca gggtcaaact gagaaattcc agtttgaact     1860

aactttagag gaagatggtg agtcagacac ggaaaaggac agtggcagtc aagtggaaga     1920

agacactagc tgcagtgact ccaagactct ttgtactcaa gactcagagt ctactgaaat     1980

tccccttgat gaacaggttg aagaggaggc agtaggggaa gaagaggaaa gccagcctga     2040

agcctgtgtc atagatgatc gttctcctga cacgtaacag tgcaaaaact ttcatgcctt     2100

tttttttttt aagtagaaaa attgtttcca aagtgcatgt cacatgccac aaccacggtc     2160

acacctcact gtcatctgcc aggacgtttg ttgaacaaaa ctgaccttga ctactcagtc     2220

cagcgctcag gaatatcgta accagttttt tcacctccat gtcatccgag caaggtggac     2280

atcttcacga acagcgtttt taacaagatt tcagcttggt agagctgaca aagcagataa     2340

aatctactcc aaattatttt caagagagtg tgactcatca ggcagcccaa aagtttattg     2400

gacttggggt ttctattcct ttttatttgt ttgcaatatt ttcagaagaa aggcattgca     2460

cagagtgaac ttaatggacg aagcaacaaa tatgtcaaga acaggacata gcacgaatct     2520

gttaccagta ggaggaggat gagccacaga aattgcataa ttttctaatt tcaagtcttc     2580

ctgatacatg actgaatagt gtggttcagt gagctgcact gacctctaca ttttgtatga     2640

tatgtaaaac agattttttg tagagcttac ttttattatt aaatgtattg aggtattata     2700

tttaaaaaaa actatgttca gaacttcatc tgccactggt tatttttttc taaggagtaa     2760

cttgcaagtt ttcagtacaa atctgtgcta cactggataa aaatctaatt tatgaatttt     2820

acttgcacct tatagttcat agcaattaac tgatttgtag tgattcattg tttgttttat     2880

ataccaatga cttccatatt ttaaaagaga aaaacaactt tatgttgcag gaaacccttt     2940

ttgtaagtct ttattattta ctttgcattt tgtttcactc tttccagata agcagagttg     3000

ctcttcacca gtgtttttct tcatgtgcaa agtgactatt tgttctataa tacttttatg     3060

tgtgttatat caaatgtgtc ttaagcttca tgcaaactca gtcatcagtt cgtgttgtct     3120

gaagcaagtg ggagatatat aaatacccag tagctaaaat ggtcagtctt ttttagatgt     3180

tttcctactt agtatctcct aataacgttt tgctgtgtca ctagatgttc atttcacaag     3240

tgcatgtctt tctaataatc cacacatttc atgctctaat aatccacaca tttcatgctc     3300

atttttattg tttttacagc cagttatagt aagaaaaagg tttttcccct tgtgctgctt     3360

tataatttag cgtgtgtctg aaccttatcc atgtttgcta gatgaggtct tgtcaaatat     3420

atcactacca ttgtcaccgg tgaaaagaaa caggtagtta agttagggtt aacattcatt     3480

tcaaccacga ggttgtatat catgactagc ttttactctt ggtttacaga gaaaagttaa     3540

acagccaact aggcagtttt taagaatatt aacaatatat taacaaacac caatacaact     3600

aatcctattt ggttttaatg atttcaccat gggattaaga actatatcag gaacatccct     3660

gagaaacggt tttaagtgta gcaactactc ttccttaatg gacagccaca taacgtgtag     3720

gaagtccttt atcacttatc ctcgatccat aagcatatct tgcagagggg aactacttct     3780

ttaaacacat ggagggaaag aagatgatgc cactggcacc agagggttag tactgtgatg     3840

catcctaaaa tatttattat attggtaaaa attctggtta aataaaaaat tagagatcac     3900

tcttggctga tttcagcacc aggaactgta ttacagtttt agagattaat tcctagtgtt     3960

tacctgatta tagcagttgg catcatgggg catttaattc tgactttatc cccacgtcag     4020

ccttaataaa gtcttcttta ccttctctat gaagacttta aagcccaaat aatcattttt     4080

cacattgata ttcaagaatt gagatagata gaagccaaag tgggtatctg acaagtggaa     4140

aatcaaacgt ttaagaagaa ttacaactct gaaaagcatt tatatgtgga acttctcaag     4200

gagcctcctg gggactggaa agtaagtcat cagccaggca aatgactcat gctgaagaga     4260

gtccccattt cagtcccctg agatctagct gatgcttaga tcctttgaaa taaaaattat     4320

gtctttataa ctctgatctt ttacataaag cagaagagga atcaactagt taattgcaag     4380

gtttctactc tgtttcctct gtaaagatca gatggtaatc tttcaaataa gaaaaaaata     4440

aagacgtatg tttgaccaag tagtttcaca agaatatttg ggaacttgtt tcttttaatt     4500

ttatttgtcc ctgagtgaag tctagaaaga aaggtaaaga gtctagagtt tattcctctt     4560

tccaaaacat tctcattcct ctcctcccta cacttagtat ttcccccaca gagtgcctag     4620

aatcttaata atgaataaaa taaaaagcag caatatgtca ttaacaaatc cagacctgaa     4680

agggtaaagg gtttataact gcactaataa agagaggctc tttttttttc ttccagtttg     4740

ttggttttta atggtaccgt gttgtaaaga tacccactaa tggacaatca aattgcagaa     4800

aaggctcaat atccaagaga cagggactaa tgcactgtac aatctgctta tccttgccct     4860

tctctcttgc caaagtgtgc ttcagaaata tatactgctt taaaaaagaa taaaagaata     4920

tccttttaca agtggcttta catttcctaa aatgccataa gaaaatgcaa tatctgggta     4980

ctgtatgggg aaaaaaatgt ccaagtttgt gtaaaaccag tgcatttcag cttgcaagtt     5040

actgaacaca ataatgctgt tttaattttg ttttatatca gttaaaattc acaataatgt     5100

agatagaaca aattacagac aaggaaagaa aaaacttgaa tgaaatggat tttacagaaa     5160

gctttatgat aatttttgaa tgcattattt attttttgtg ccatgcattt tttttctcac     5220

caaatgacct tacctgtaat acagtcttgt ttgtctgttt acaaccatgt atttattgca     5280

atgtacatac tgtaatgtta attgtaaatt atctgttctt attaaaacat catcccatga     5340

tgggatggtg ttgatatatt tggaaactct tggtgagaga atgaatggtg tgtatacata     5400

ctctgtacat ttttcttttc tcctgtaata tagtcttgtc accttagagc ttgtttatgg     5460

aagattcaag aaaactataa aatacttaaa gatatataaa tttaaaaaaa catagctgca     5520

ggtctttggt cccagggctg tgccttaact ttaaccaata ttttcttctg ttttgctgca     5580

tttgaaaggt aacagtggag ctagggctgg gcattttaca tccaggcttt taattgatta     5640

gaattctgcc aataggtgga ttttacaaaa ccacagacaa cctctgaaag attctgagac     5700

ccttttgaga cagaagctct taagtacttc ttgccaggga gcagcactgc atgtgtgatg     5760

gttgtttgcc atctgttgat caggaactac ttcagctact tgcatttgat tatttccttt     5820

tttttttttt ttaactcgga aacacaactg gggaaatata ttctttccca gtgattataa     5880

acaatctttt tctttttttt aagtcctttt ggcttctaga gctcatagga aaatggactt     5940

gatttgaaat tggagccaga gtttactcgt gttggttatc tattcatcag cttcctgaca     6000

tgttaagaga atacattaaa gagaaaatac tgttttttaa tcctaaaatt tttcttccac     6060

taagataaac caaatgtcct tacatatatg taaacccatc tatttaaacg caaaggtggg     6120

ttgatgtcag tttacatagc agaaagcatt cactatcctc taagatttgt ttctgcaaaa     6180

ctttcattgc tttagaattt taaaatttca ccttgtacaa tggccagccc ctaaagcagg     6240

aaacatttat aatggattat atggaaacat cctcccagta cttgcccagc ccttgaatca     6300

tgtggctttt cagtgaaagg aaagattctt tttctaggaa aaatgagcct attttatttt     6360

attttatttt attttttgac acaaactgta gattttagca gccctggccc aaaggaattt     6420

gattactttt gttttaaaca gtacaaaggg gacactataa ttacaaaaac atccttaact     6480

gatttgagtt gtttttattt ctttggatat attttcagag tggtaaattg tgtgtgagaa     6540

ttacaaatga ttattctttt agtggtttct tagcctctct tacagcccac ggggatagta     6600

ctgtacatca ataccttcat atgaaatttt tatatgcaat gaaaataaaa gcatgggttg     6660

attctgccta tttatgactc aatcttttac aaataaaaga ttattcattt taaattatag     6720

ttcaatcagc atgtctctta ggatactgaa cgtggttgaa atgaaaggat agtgacatca     6780

taagttagta ctgatattca taaccaaata aagccaactt gagtaatttt gctacattaa     6840

aaattaccaa aattacttag atggcctata agattaagca tggtgttttc taagcaagct     6900

ttgaaagggg ccttccatac ttacttaatt gaatattctg ggatattgaa aattattcag     6960

atacttgaca attatttttg gttacctact ccgcaaacta caaagtttta aggactcaac     7020

aataagttaa tgagacacag tgtttgcttt catggagctt acagtctgga ggggacaaag     7080

gcttaaacaa tactcatata attatatatg tgatcagtac aatgaaggag ctcagtgggg     7140

taaataagca ggaacctgaa cttgatctgt tccggagggc cacagaaggc ttccttgagg     7200

ccttgagaaa gtgatttgca tctgagttct gaaggattgt aagaggtaac tagggaaaaa     7260

gttgacagga agaggaaggg gatccagaca agaaacattt gcaaagatct tgaggcataa     7320

atgagcttga gacatctgga gaaactgagg aaaagtgaga gagtaggcag ggcctggagc     7380

cgcagagcca ttgctaacca tcctgtgtga gatatccccc attctgtagc tttattctca     7440

taaccctgct caattttctt tataacactt ctcacagatt tatatacgtg tttgtttttg     7500

ttatctgtct ctcccaccag accacagctc catgagagca aggtctttgc ttaccaatat     7560

atcactagca cttaaaacta tgcctggtac acagtaggtt cttaatatgt gttgaatata     7620

gccatcaaat tgatattgga tataattcaa tctgataaga tattttgaga tattaaagag     7680

tttttaactt gataccataa aaaaaaaaaa aaaaa                                7715


<210>  7
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
1               5                   10                  15      


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser 
            20                  25                  30          


Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr 
        35                  40                  45              


Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly 
    50                  55                  60                  


Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro 
65                  70                  75                  80  


Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu 
                85                  90                  95      


Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu 
            100                 105                 110         


Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu 
        115                 120                 125             


Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr 
    130                 135                 140                 


Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His 
145                 150                 155                 160 


Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu 
                165                 170                 175     


Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala 
            180                 185                 190         


Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser 
        195                 200                 205             


Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn 
    210                 215                 220                 


Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln 
                245                 250                 255     


Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp 
            260                 265                 270         


Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu 
        275                 280                 285             


Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser 
    290                 295                 300                 


Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser 
305                 310                 315                 320 


Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile 
                325                 330                 335     


Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met 
            340                 345                 350         


Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser 
        355                 360                 365             


Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp 
    370                 375                 380                 


Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu 
385                 390                 395                 400 


Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro 
                405                 410                 415     


Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe 
            420                 425                 430         


Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys 
        435                 440                 445             


Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys 
    450                 455                 460                 


Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu 
465                 470                 475                 480 


Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu 
                485                 490                 495     


Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            500                 505         


<210>  8
<211>  7783
<212>  DNA
<213>  Homo sapiens

<400>  8
aatacttgtt gcaataattg cccacgatag ctgctcaaac aagagagttg gaattcatct       60

gtaaaaatca ctacatgtaa cgtaggagac aagaaaaata ttaatgacag aagatctgcg      120

aacatgatgc acgtgaataa ttttcccttt agaaggcatt cctggatatg ttttgatgtg      180

gacaatggca catctgcggg acggagtccc ttggatccca tgaccagccc aggatccggg      240

ctaattctcc aagcaaattt tgtccacagt caacgacggg agtccttcct gtatcgatcc      300

gacagcgatt atgacctctc tccaaagtct atgtcccgga actcctccat tgccagtgat      360

atacacggag atgacttgat tgtgactcca tttgctcagg tcttggccag tctgcgaact      420

gtacgaaaca actttgctgc attaactaat ttgcaagatc gagcacctag caaaagatca      480

cccatgtgca accaaccatc catcaacaaa gccaccataa cagaggaggc ctaccagaaa      540

ctggccagcg agaccctgga ggagctggac tggtgtctgg accagctaga gaccctacag      600

accaggcact ccgtcagtga gatggcctcc aacaagttta aaaggatgct taatcgggag      660

ctcacccatc tctctgaaat gagtcggtct ggaaatcaag tgtcagagtt tatatcaaac      720

acattcttag ataagcaaca tgaagtggaa attccttctc caactcagaa ggaaaaggag      780

aaaaagaaaa gaccaatgtc tcagatcagt ggagtcaaga aattgatgca cagctctagt      840

ctgactaatt caagtatccc aaggtttgga gttaaaactg aacaagaaga tgtccttgcc      900

aaggaactag aagatgtgaa caaatggggt cttcatgttt tcagaatagc agagttgtct      960

ggtaaccggc ccttgactgt tatcatgcac accatttttc aggaacggga tttattaaaa     1020

acatttaaaa ttccagtaga tactttaatt acatatctta tgactctcga agaccattac     1080

catgctgatg tggcctatca caacaatatc catgctgcag atgttgtcca gtctactcat     1140

gtgctattat ctacacctgc tttggaggct gtgtttacag atttggagat tcttgcagca     1200

atttttgcca gtgcaataca tgatgtagat catcctggtg tgtccaatca atttctgatc     1260

aatacaaact ctgaacttgc cttgatgtac aatgattcct cagtcttaga gaaccatcat     1320

ttggctgtgg gctttaaatt gcttcaggaa gaaaactgtg acattttcca gaatttgacc     1380

aaaaaacaaa gacaatcttt aaggaaaatg gtcattgaca tcgtacttgc aacagatatg     1440

tcaaaacaca tgaatctact ggctgatttg aagactatgg ttgaaactaa gaaagtgaca     1500

agctctggag ttcttcttct tgataattat tccgatagga ttcaggttct tcagaatatg     1560

gtgcactgtg cagatctgag caacccaaca aagcctctcc agctgtaccg ccagtggacg     1620

gaccggataa tggaggagtt cttccgccaa ggagaccgag agagggaacg tggcatggag     1680

ataagcccca tgtgtgacaa gcacaatgct tccgtggaaa aatcacaggt gggcttcata     1740

gactatattg ttcatcccct ctgggagaca tgggcagacc tcgtccaccc tgacgcccag     1800

gatattttgg acactttgga ggacaatcgt gaatggtacc agagcacaat ccctcagagc     1860

ccctctcctg cacctgatga cccagaggag ggccggcagg gtcaaactga gaaattccag     1920

tttgaactaa ctttagagga agatggtgag tcagacacgg aaaaggacag tggcagtcaa     1980

gtggaagaag acactagctg cagtgactcc aagactcttt gtactcaaga ctcagagtct     2040

actgaaattc cccttgatga acaggttgaa gaggaggcag taggggaaga agaggaaagc     2100

cagcctgaag cctgtgtcat agatgatcgt tctcctgaca cgtaacagtg caaaaacttt     2160

catgcctttt ttttttttaa gtagaaaaat tgtttccaaa gtgcatgtca catgccacaa     2220

ccacggtcac acctcactgt catctgccag gacgtttgtt gaacaaaact gaccttgact     2280

actcagtcca gcgctcagga atatcgtaac cagttttttc acctccatgt catccgagca     2340

aggtggacat cttcacgaac agcgttttta acaagatttc agcttggtag agctgacaaa     2400

gcagataaaa tctactccaa attattttca agagagtgtg actcatcagg cagcccaaaa     2460

gtttattgga cttggggttt ctattccttt ttatttgttt gcaatatttt cagaagaaag     2520

gcattgcaca gagtgaactt aatggacgaa gcaacaaata tgtcaagaac aggacatagc     2580

acgaatctgt taccagtagg aggaggatga gccacagaaa ttgcataatt ttctaatttc     2640

aagtcttcct gatacatgac tgaatagtgt ggttcagtga gctgcactga cctctacatt     2700

ttgtatgata tgtaaaacag attttttgta gagcttactt ttattattaa atgtattgag     2760

gtattatatt taaaaaaaac tatgttcaga acttcatctg ccactggtta tttttttcta     2820

aggagtaact tgcaagtttt cagtacaaat ctgtgctaca ctggataaaa atctaattta     2880

tgaattttac ttgcacctta tagttcatag caattaactg atttgtagtg attcattgtt     2940

tgttttatat accaatgact tccatatttt aaaagagaaa aacaacttta tgttgcagga     3000

aacccttttt gtaagtcttt attatttact ttgcattttg tttcactctt tccagataag     3060

cagagttgct cttcaccagt gtttttcttc atgtgcaaag tgactatttg ttctataata     3120

cttttatgtg tgttatatca aatgtgtctt aagcttcatg caaactcagt catcagttcg     3180

tgttgtctga agcaagtggg agatatataa atacccagta gctaaaatgg tcagtctttt     3240

ttagatgttt tcctacttag tatctcctaa taacgttttg ctgtgtcact agatgttcat     3300

ttcacaagtg catgtctttc taataatcca cacatttcat gctctaataa tccacacatt     3360

tcatgctcat ttttattgtt tttacagcca gttatagtaa gaaaaaggtt tttccccttg     3420

tgctgcttta taatttagcg tgtgtctgaa ccttatccat gtttgctaga tgaggtcttg     3480

tcaaatatat cactaccatt gtcaccggtg aaaagaaaca ggtagttaag ttagggttaa     3540

cattcatttc aaccacgagg ttgtatatca tgactagctt ttactcttgg tttacagaga     3600

aaagttaaac agccaactag gcagttttta agaatattaa caatatatta acaaacacca     3660

atacaactaa tcctatttgg ttttaatgat ttcaccatgg gattaagaac tatatcagga     3720

acatccctga gaaacggttt taagtgtagc aactactctt ccttaatgga cagccacata     3780

acgtgtagga agtcctttat cacttatcct cgatccataa gcatatcttg cagaggggaa     3840

ctacttcttt aaacacatgg agggaaagaa gatgatgcca ctggcaccag agggttagta     3900

ctgtgatgca tcctaaaata tttattatat tggtaaaaat tctggttaaa taaaaaatta     3960

gagatcactc ttggctgatt tcagcaccag gaactgtatt acagttttag agattaattc     4020

ctagtgttta cctgattata gcagttggca tcatggggca tttaattctg actttatccc     4080

cacgtcagcc ttaataaagt cttctttacc ttctctatga agactttaaa gcccaaataa     4140

tcatttttca cattgatatt caagaattga gatagataga agccaaagtg ggtatctgac     4200

aagtggaaaa tcaaacgttt aagaagaatt acaactctga aaagcattta tatgtggaac     4260

ttctcaagga gcctcctggg gactggaaag taagtcatca gccaggcaaa tgactcatgc     4320

tgaagagagt ccccatttca gtcccctgag atctagctga tgcttagatc ctttgaaata     4380

aaaattatgt ctttataact ctgatctttt acataaagca gaagaggaat caactagtta     4440

attgcaaggt ttctactctg tttcctctgt aaagatcaga tggtaatctt tcaaataaga     4500

aaaaaataaa gacgtatgtt tgaccaagta gtttcacaag aatatttggg aacttgtttc     4560

ttttaatttt atttgtccct gagtgaagtc tagaaagaaa ggtaaagagt ctagagttta     4620

ttcctctttc caaaacattc tcattcctct cctccctaca cttagtattt cccccacaga     4680

gtgcctagaa tcttaataat gaataaaata aaaagcagca atatgtcatt aacaaatcca     4740

gacctgaaag ggtaaagggt ttataactgc actaataaag agaggctctt tttttttctt     4800

ccagtttgtt ggtttttaat ggtaccgtgt tgtaaagata cccactaatg gacaatcaaa     4860

ttgcagaaaa ggctcaatat ccaagagaca gggactaatg cactgtacaa tctgcttatc     4920

cttgcccttc tctcttgcca aagtgtgctt cagaaatata tactgcttta aaaaagaata     4980

aaagaatatc cttttacaag tggctttaca tttcctaaaa tgccataaga aaatgcaata     5040

tctgggtact gtatggggaa aaaaatgtcc aagtttgtgt aaaaccagtg catttcagct     5100

tgcaagttac tgaacacaat aatgctgttt taattttgtt ttatatcagt taaaattcac     5160

aataatgtag atagaacaaa ttacagacaa ggaaagaaaa aacttgaatg aaatggattt     5220

tacagaaagc tttatgataa tttttgaatg cattatttat tttttgtgcc atgcattttt     5280

tttctcacca aatgacctta cctgtaatac agtcttgttt gtctgtttac aaccatgtat     5340

ttattgcaat gtacatactg taatgttaat tgtaaattat ctgttcttat taaaacatca     5400

tcccatgatg ggatggtgtt gatatatttg gaaactcttg gtgagagaat gaatggtgtg     5460

tatacatact ctgtacattt ttcttttctc ctgtaatata gtcttgtcac cttagagctt     5520

gtttatggaa gattcaagaa aactataaaa tacttaaaga tatataaatt taaaaaaaca     5580

tagctgcagg tctttggtcc cagggctgtg ccttaacttt aaccaatatt ttcttctgtt     5640

ttgctgcatt tgaaaggtaa cagtggagct agggctgggc attttacatc caggctttta     5700

attgattaga attctgccaa taggtggatt ttacaaaacc acagacaacc tctgaaagat     5760

tctgagaccc ttttgagaca gaagctctta agtacttctt gccagggagc agcactgcat     5820

gtgtgatggt tgtttgccat ctgttgatca ggaactactt cagctacttg catttgatta     5880

tttccttttt tttttttttt aactcggaaa cacaactggg gaaatatatt ctttcccagt     5940

gattataaac aatctttttc ttttttttaa gtccttttgg cttctagagc tcataggaaa     6000

atggacttga tttgaaattg gagccagagt ttactcgtgt tggttatcta ttcatcagct     6060

tcctgacatg ttaagagaat acattaaaga gaaaatactg ttttttaatc ctaaaatttt     6120

tcttccacta agataaacca aatgtcctta catatatgta aacccatcta tttaaacgca     6180

aaggtgggtt gatgtcagtt tacatagcag aaagcattca ctatcctcta agatttgttt     6240

ctgcaaaact ttcattgctt tagaatttta aaatttcacc ttgtacaatg gccagcccct     6300

aaagcaggaa acatttataa tggattatat ggaaacatcc tcccagtact tgcccagccc     6360

ttgaatcatg tggcttttca gtgaaaggaa agattctttt tctaggaaaa atgagcctat     6420

tttattttat tttattttat tttttgacac aaactgtaga ttttagcagc cctggcccaa     6480

aggaatttga ttacttttgt tttaaacagt acaaagggga cactataatt acaaaaacat     6540

ccttaactga tttgagttgt ttttatttct ttggatatat tttcagagtg gtaaattgtg     6600

tgtgagaatt acaaatgatt attcttttag tggtttctta gcctctctta cagcccacgg     6660

ggatagtact gtacatcaat accttcatat gaaattttta tatgcaatga aaataaaagc     6720

atgggttgat tctgcctatt tatgactcaa tcttttacaa ataaaagatt attcatttta     6780

aattatagtt caatcagcat gtctcttagg atactgaacg tggttgaaat gaaaggatag     6840

tgacatcata agttagtact gatattcata accaaataaa gccaacttga gtaattttgc     6900

tacattaaaa attaccaaaa ttacttagat ggcctataag attaagcatg gtgttttcta     6960

agcaagcttt gaaaggggcc ttccatactt acttaattga atattctggg atattgaaaa     7020

ttattcagat acttgacaat tatttttggt tacctactcc gcaaactaca aagttttaag     7080

gactcaacaa taagttaatg agacacagtg tttgctttca tggagcttac agtctggagg     7140

ggacaaaggc ttaaacaata ctcatataat tatatatgtg atcagtacaa tgaaggagct     7200

cagtggggta aataagcagg aacctgaact tgatctgttc cggagggcca cagaaggctt     7260

ccttgaggcc ttgagaaagt gatttgcatc tgagttctga aggattgtaa gaggtaacta     7320

gggaaaaagt tgacaggaag aggaagggga tccagacaag aaacatttgc aaagatcttg     7380

aggcataaat gagcttgaga catctggaga aactgaggaa aagtgagaga gtaggcaggg     7440

cctggagccg cagagccatt gctaaccatc ctgtgtgaga tatcccccat tctgtagctt     7500

tattctcata accctgctca attttcttta taacacttct cacagattta tatacgtgtt     7560

tgtttttgtt atctgtctct cccaccagac cacagctcca tgagagcaag gtctttgctt     7620

accaatatat cactagcact taaaactatg cctggtacac agtaggttct taatatgtgt     7680

tgaatatagc catcaaattg atattggata taattcaatc tgataagata ttttgagata     7740

ttaaagagtt tttaacttga taccataaaa aaaaaaaaaa aaa                       7783


<210>  9
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Met His Val Asn Asn Phe Pro Phe Arg Arg His Ser Trp Ile Cys 
1               5                   10                  15      


Phe Asp Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro 
            20                  25                  30          


Met Thr Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His 
        35                  40                  45              


Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp 
    50                  55                  60                  


Leu Ser Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile 
65                  70                  75                  80  


His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser 
                85                  90                  95      


Leu Arg Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp 
            100                 105                 110         


Arg Ala Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn 
        115                 120                 125             


Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr 
    130                 135                 140                 


Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr 
145                 150                 155                 160 


Arg His Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu 
                165                 170                 175     


Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln 
            180                 185                 190         


Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val 
        195                 200                 205             


Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro 
    210                 215                 220                 


Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp 
                245                 250                 255     


Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val 
            260                 265                 270         


Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met 
        275                 280                 285             


His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro 
    290                 295                 300                 


Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His 
305                 310                 315                 320 


Ala Asp Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln 
                325                 330                 335     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr 
            340                 345                 350         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val 
        355                 360                 365             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    370                 375                 380                 


Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu 
385                 390                 395                 400 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln 
                405                 410                 415     


Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp 
            420                 425                 430         


Ile Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp 
        435                 440                 445             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    450                 455                 460                 


Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val 
465                 470                 475                 480 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg 
                485                 490                 495     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg 
            500                 505                 510         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn 
        515                 520                 525             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    530                 535                 540                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp 
545                 550                 555                 560 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile 
                565                 570                 575     


Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln 
            580                 585                 590         


Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly 
        595                 600                 605             


Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr 
    610                 615                 620                 


Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr 
625                 630                 635                 640 


Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu 
                645                 650                 655     


Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp 
            660                 665                 670         


Thr 
    


<210>  10
<211>  8240
<212>  DNA
<213>  Homo sapiens

<400>  10
cccctctcgg tagccctgag gctctggcgc cttcaagtga gaagctaagc accagcctct       60

gctgggctgc agaagcggcg gcggcggcag cagcagcagc agcatcagga aggcgctcgg      120

gccagcgcgg tgaacccggg ctgggcagca ggtcgcggag ccgcgagcca ggatggaggc      180

agagggcagc agcgcgccgg cccgggcggg cagcggagag ggcagcgaca gcgccggcgg      240

ggccacgctc aaagccccca agcatctctg gaggcacgag cagcaccacc agtacccgct      300

ccggcagccc cagttccgcc tcctgcatcc ccatcaccac ctgcccccgc cgccgccacc      360

ctcgccccag ccccagcccc agtgtccgct acagccgccg ccgccgcccc ccctgccgcc      420

gcccccgccg ccgcccgggg ctgcccgcgg ccgctacgcc tcgagcgggg ccaccggccg      480

cgtccggcat cgcggctact cggacaccga gcgctacctg tactgtcgcg ccatggaccg      540

cacctcctac gcggtggaga ccggccaccg gcccggcctg aagaaatcca ggatgtcctg      600

gccctcctcg ttccagggac tcaggcgttt tgatgtggac aatggcacat ctgcgggacg      660

gagtcccttg gatcccatga ccagcccagg atccgggcta attctccaag caaattttgt      720

ccacagtcaa cgacgggagt ccttcctgta tcgatccgac agcgattatg acctctctcc      780

aaagtctatg tcccggaact cctccattgc cagtgatata cacggagatg acttgattgt      840

gactccattt gctcaggtct tggccagtct gcgaactgta cgaaacaact ttgctgcatt      900

aactaatttg caagatcgag cacctagcaa aagatcaccc atgtgcaacc aaccatccat      960

caacaaagcc accataacag aggaggccta ccagaaactg gccagcgaga ccctggagga     1020

gctggactgg tgtctggacc agctagagac cctacagacc aggcactccg tcagtgagat     1080

ggcctccaac aagtttaaaa ggatgcttaa tcgggagctc acccatctct ctgaaatgag     1140

tcggtctgga aatcaagtgt cagagtttat atcaaacaca ttcttagata agcaacatga     1200

agtggaaatt ccttctccaa ctcagaagga aaaggagaaa aagaaaagac caatgtctca     1260

gatcagtgga gtcaagaaat tgatgcacag ctctagtctg actaattcaa gtatcccaag     1320

gtttggagtt aaaactgaac aagaagatgt ccttgccaag gaactagaag atgtgaacaa     1380

atggggtctt catgttttca gaatagcaga gttgtctggt aaccggccct tgactgttat     1440

catgcacacc atttttcagg aacgggattt attaaaaaca tttaaaattc cagtagatac     1500

tttaattaca tatcttatga ctctcgaaga ccattaccat gctgatgtgg cctatcacaa     1560

caatatccat gctgcagatg ttgtccagtc tactcatgtg ctattatcta cacctgcttt     1620

ggaggctgtg tttacagatt tggagattct tgcagcaatt tttgccagtg caatacatga     1680

tgtagatcat cctggtgtgt ccaatcaatt tctgatcaat acaaactctg aacttgcctt     1740

gatgtacaat gattcctcag tcttagagaa ccatcatttg gctgtgggct ttaaattgct     1800

tcaggaagaa aactgtgaca ttttccagaa tttgaccaaa aaacaaagac aatctttaag     1860

gaaaatggtc attgacatcg tacttgcaac agatatgtca aaacacatga atctactggc     1920

tgatttgaag actatggttg aaactaagaa agtgacaagc tctggagttc ttcttcttga     1980

taattattcc gataggattc aggttcttca gaatatggtg cactgtgcag atctgagcaa     2040

cccaacaaag cctctccagc tgtaccgcca gtggacggac cggataatgg aggagttctt     2100

ccgccaagga gaccgagaga gggaacgtgg catggagata agccccatgt gtgacaagca     2160

caatgcttcc gtggaaaaat cacaggtggg cttcatagac tatattgttc atcccctctg     2220

ggagacatgg gcagacctcg tccaccctga cgcccaggat attttggaca ctttggagga     2280

caatcgtgaa tggtaccaga gcacaatccc tcagagcccc tctcctgcac ctgatgaccc     2340

agaggagggc cggcagggtc aaactgagaa attccagttt gaactaactt tagaggaaga     2400

tggtgagtca gacacggaaa aggacagtgg cagtcaagtg gaagaagaca ctagctgcag     2460

tgactccaag actctttgta ctcaagactc agagtctact gaaattcccc ttgatgaaca     2520

ggttgaagag gaggcagtag gggaagaaga ggaaagccag cctgaagcct gtgtcataga     2580

tgatcgttct cctgacacgt aacagtgcaa aaactttcat gccttttttt tttttaagta     2640

gaaaaattgt ttccaaagtg catgtcacat gccacaacca cggtcacacc tcactgtcat     2700

ctgccaggac gtttgttgaa caaaactgac cttgactact cagtccagcg ctcaggaata     2760

tcgtaaccag ttttttcacc tccatgtcat ccgagcaagg tggacatctt cacgaacagc     2820

gtttttaaca agatttcagc ttggtagagc tgacaaagca gataaaatct actccaaatt     2880

attttcaaga gagtgtgact catcaggcag cccaaaagtt tattggactt ggggtttcta     2940

ttccttttta tttgtttgca atattttcag aagaaaggca ttgcacagag tgaacttaat     3000

ggacgaagca acaaatatgt caagaacagg acatagcacg aatctgttac cagtaggagg     3060

aggatgagcc acagaaattg cataattttc taatttcaag tcttcctgat acatgactga     3120

atagtgtggt tcagtgagct gcactgacct ctacattttg tatgatatgt aaaacagatt     3180

ttttgtagag cttactttta ttattaaatg tattgaggta ttatatttaa aaaaaactat     3240

gttcagaact tcatctgcca ctggttattt ttttctaagg agtaacttgc aagttttcag     3300

tacaaatctg tgctacactg gataaaaatc taatttatga attttacttg caccttatag     3360

ttcatagcaa ttaactgatt tgtagtgatt cattgtttgt tttatatacc aatgacttcc     3420

atattttaaa agagaaaaac aactttatgt tgcaggaaac cctttttgta agtctttatt     3480

atttactttg cattttgttt cactctttcc agataagcag agttgctctt caccagtgtt     3540

tttcttcatg tgcaaagtga ctatttgttc tataatactt ttatgtgtgt tatatcaaat     3600

gtgtcttaag cttcatgcaa actcagtcat cagttcgtgt tgtctgaagc aagtgggaga     3660

tatataaata cccagtagct aaaatggtca gtctttttta gatgttttcc tacttagtat     3720

ctcctaataa cgttttgctg tgtcactaga tgttcatttc acaagtgcat gtctttctaa     3780

taatccacac atttcatgct ctaataatcc acacatttca tgctcatttt tattgttttt     3840

acagccagtt atagtaagaa aaaggttttt ccccttgtgc tgctttataa tttagcgtgt     3900

gtctgaacct tatccatgtt tgctagatga ggtcttgtca aatatatcac taccattgtc     3960

accggtgaaa agaaacaggt agttaagtta gggttaacat tcatttcaac cacgaggttg     4020

tatatcatga ctagctttta ctcttggttt acagagaaaa gttaaacagc caactaggca     4080

gtttttaaga atattaacaa tatattaaca aacaccaata caactaatcc tatttggttt     4140

taatgatttc accatgggat taagaactat atcaggaaca tccctgagaa acggttttaa     4200

gtgtagcaac tactcttcct taatggacag ccacataacg tgtaggaagt cctttatcac     4260

ttatcctcga tccataagca tatcttgcag aggggaacta cttctttaaa cacatggagg     4320

gaaagaagat gatgccactg gcaccagagg gttagtactg tgatgcatcc taaaatattt     4380

attatattgg taaaaattct ggttaaataa aaaattagag atcactcttg gctgatttca     4440

gcaccaggaa ctgtattaca gttttagaga ttaattccta gtgtttacct gattatagca     4500

gttggcatca tggggcattt aattctgact ttatccccac gtcagcctta ataaagtctt     4560

ctttaccttc tctatgaaga ctttaaagcc caaataatca tttttcacat tgatattcaa     4620

gaattgagat agatagaagc caaagtgggt atctgacaag tggaaaatca aacgtttaag     4680

aagaattaca actctgaaaa gcatttatat gtggaacttc tcaaggagcc tcctggggac     4740

tggaaagtaa gtcatcagcc aggcaaatga ctcatgctga agagagtccc catttcagtc     4800

ccctgagatc tagctgatgc ttagatcctt tgaaataaaa attatgtctt tataactctg     4860

atcttttaca taaagcagaa gaggaatcaa ctagttaatt gcaaggtttc tactctgttt     4920

cctctgtaaa gatcagatgg taatctttca aataagaaaa aaataaagac gtatgtttga     4980

ccaagtagtt tcacaagaat atttgggaac ttgtttcttt taattttatt tgtccctgag     5040

tgaagtctag aaagaaaggt aaagagtcta gagtttattc ctctttccaa aacattctca     5100

ttcctctcct ccctacactt agtatttccc ccacagagtg cctagaatct taataatgaa     5160

taaaataaaa agcagcaata tgtcattaac aaatccagac ctgaaagggt aaagggttta     5220

taactgcact aataaagaga ggctcttttt ttttcttcca gtttgttggt ttttaatggt     5280

accgtgttgt aaagataccc actaatggac aatcaaattg cagaaaaggc tcaatatcca     5340

agagacaggg actaatgcac tgtacaatct gcttatcctt gcccttctct cttgccaaag     5400

tgtgcttcag aaatatatac tgctttaaaa aagaataaaa gaatatcctt ttacaagtgg     5460

ctttacattt cctaaaatgc cataagaaaa tgcaatatct gggtactgta tggggaaaaa     5520

aatgtccaag tttgtgtaaa accagtgcat ttcagcttgc aagttactga acacaataat     5580

gctgttttaa ttttgtttta tatcagttaa aattcacaat aatgtagata gaacaaatta     5640

cagacaagga aagaaaaaac ttgaatgaaa tggattttac agaaagcttt atgataattt     5700

ttgaatgcat tatttatttt ttgtgccatg catttttttt ctcaccaaat gaccttacct     5760

gtaatacagt cttgtttgtc tgtttacaac catgtattta ttgcaatgta catactgtaa     5820

tgttaattgt aaattatctg ttcttattaa aacatcatcc catgatggga tggtgttgat     5880

atatttggaa actcttggtg agagaatgaa tggtgtgtat acatactctg tacatttttc     5940

ttttctcctg taatatagtc ttgtcacctt agagcttgtt tatggaagat tcaagaaaac     6000

tataaaatac ttaaagatat ataaatttaa aaaaacatag ctgcaggtct ttggtcccag     6060

ggctgtgcct taactttaac caatattttc ttctgttttg ctgcatttga aaggtaacag     6120

tggagctagg gctgggcatt ttacatccag gcttttaatt gattagaatt ctgccaatag     6180

gtggatttta caaaaccaca gacaacctct gaaagattct gagacccttt tgagacagaa     6240

gctcttaagt acttcttgcc agggagcagc actgcatgtg tgatggttgt ttgccatctg     6300

ttgatcagga actacttcag ctacttgcat ttgattattt cctttttttt tttttttaac     6360

tcggaaacac aactggggaa atatattctt tcccagtgat tataaacaat ctttttcttt     6420

tttttaagtc cttttggctt ctagagctca taggaaaatg gacttgattt gaaattggag     6480

ccagagttta ctcgtgttgg ttatctattc atcagcttcc tgacatgtta agagaataca     6540

ttaaagagaa aatactgttt tttaatccta aaatttttct tccactaaga taaaccaaat     6600

gtccttacat atatgtaaac ccatctattt aaacgcaaag gtgggttgat gtcagtttac     6660

atagcagaaa gcattcacta tcctctaaga tttgtttctg caaaactttc attgctttag     6720

aattttaaaa tttcaccttg tacaatggcc agcccctaaa gcaggaaaca tttataatgg     6780

attatatgga aacatcctcc cagtacttgc ccagcccttg aatcatgtgg cttttcagtg     6840

aaaggaaaga ttctttttct aggaaaaatg agcctatttt attttatttt attttatttt     6900

ttgacacaaa ctgtagattt tagcagccct ggcccaaagg aatttgatta cttttgtttt     6960

aaacagtaca aaggggacac tataattaca aaaacatcct taactgattt gagttgtttt     7020

tatttctttg gatatatttt cagagtggta aattgtgtgt gagaattaca aatgattatt     7080

cttttagtgg tttcttagcc tctcttacag cccacgggga tagtactgta catcaatacc     7140

ttcatatgaa atttttatat gcaatgaaaa taaaagcatg ggttgattct gcctatttat     7200

gactcaatct tttacaaata aaagattatt cattttaaat tatagttcaa tcagcatgtc     7260

tcttaggata ctgaacgtgg ttgaaatgaa aggatagtga catcataagt tagtactgat     7320

attcataacc aaataaagcc aacttgagta attttgctac attaaaaatt accaaaatta     7380

cttagatggc ctataagatt aagcatggtg ttttctaagc aagctttgaa aggggccttc     7440

catacttact taattgaata ttctgggata ttgaaaatta ttcagatact tgacaattat     7500

ttttggttac ctactccgca aactacaaag ttttaaggac tcaacaataa gttaatgaga     7560

cacagtgttt gctttcatgg agcttacagt ctggagggga caaaggctta aacaatactc     7620

atataattat atatgtgatc agtacaatga aggagctcag tggggtaaat aagcaggaac     7680

ctgaacttga tctgttccgg agggccacag aaggcttcct tgaggccttg agaaagtgat     7740

ttgcatctga gttctgaagg attgtaagag gtaactaggg aaaaagttga caggaagagg     7800

aaggggatcc agacaagaaa catttgcaaa gatcttgagg cataaatgag cttgagacat     7860

ctggagaaac tgaggaaaag tgagagagta ggcagggcct ggagccgcag agccattgct     7920

aaccatcctg tgtgagatat cccccattct gtagctttat tctcataacc ctgctcaatt     7980

ttctttataa cacttctcac agatttatat acgtgtttgt ttttgttatc tgtctctccc     8040

accagaccac agctccatga gagcaaggtc tttgcttacc aatatatcac tagcacttaa     8100

aactatgcct ggtacacagt aggttcttaa tatgtgttga atatagccat caaattgata     8160

ttggatataa ttcaatctga taagatattt tgagatatta aagagttttt aacttgatac     8220

cataaaaaaa aaaaaaaaaa                                                 8240


<210>  11
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Ala Glu Gly Ser Ser Ala Pro Ala Arg Ala Gly Ser Gly Glu 
1               5                   10                  15      


Gly Ser Asp Ser Ala Gly Gly Ala Thr Leu Lys Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg His Glu Gln His His Gln Tyr Pro Leu Arg Gln Pro Gln Phe 
        35                  40                  45              


Arg Leu Leu His Pro His His His Leu Pro Pro Pro Pro Pro Pro Ser 
    50                  55                  60                  


Pro Gln Pro Gln Pro Gln Cys Pro Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Pro Pro Pro Pro Gly Ala Ala Arg Gly Arg Tyr Ala 
                85                  90                  95      


Ser Ser Gly Ala Thr Gly Arg Val Arg His Arg Gly Tyr Ser Asp Thr 
            100                 105                 110         


Glu Arg Tyr Leu Tyr Cys Arg Ala Met Asp Arg Thr Ser Tyr Ala Val 
        115                 120                 125             


Glu Thr Gly His Arg Pro Gly Leu Lys Lys Ser Arg Met Ser Trp Pro 
    130                 135                 140                 


Ser Ser Phe Gln Gly Leu Arg Arg Phe Asp Val Asp Asn Gly Thr Ser 
145                 150                 155                 160 


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
                165                 170                 175     


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
            180                 185                 190         


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
        195                 200                 205             


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
    210                 215                 220                 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
225                 230                 235                 240 


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
                245                 250                 255     


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
            260                 265                 270         


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
        275                 280                 285             


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
    290                 295                 300                 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
305                 310                 315                 320 


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
                325                 330                 335     


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
            340                 345                 350         


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
        355                 360                 365             


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
    370                 375                 380                 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
385                 390                 395                 400 


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
                405                 410                 415     


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
            420                 425                 430         


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
        435                 440                 445             


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
    450                 455                 460                 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
465                 470                 475                 480 


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
                485                 490                 495     


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
            500                 505                 510         


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
        515                 520                 525             


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
    530                 535                 540                 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
545                 550                 555                 560 


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
                565                 570                 575     


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
            580                 585                 590         


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
        595                 600                 605             


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
    610                 615                 620                 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
625                 630                 635                 640 


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
                645                 650                 655     


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
            660                 665                 670         


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
        675                 680                 685             


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
    690                 695                 700                 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
705                 710                 715                 720 


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
                725                 730                 735     


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
            740                 745                 750         


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
        755                 760                 765             


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
    770                 775                 780                 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
785                 790                 795                 800 


Val Ile Asp Asp Arg Ser Pro Asp Thr 
                805                 


<210>  12
<211>  7979
<212>  DNA
<213>  Homo sapiens

<400>  12
cagcagcagg ctcagacctg cttccctgga catttccggg accgtgagcg agggaaccac       60

gttgccctgg attcttgcca gctgtacaaa gttgaccagg aaaatggctc agcagacaag      120

cccggacact ttaacagtac ctgaagtgga taatccgcat tgtccaaacc cgtggctgaa      180

cgaagacctt gtgaaatcct tgcgagaaaa cctgttgcag catgagaagt ccaagacagc      240

gaggaaatcg gtttctccca agctctctcc agtgatctct ccgagaaatt cccccaggct      300

tctgcgcaga atgcttctca gcagcaacat ccccaaacag cggcgtttca cggtggcaca      360

tacatgtttt gatgtggaca atggcacatc tgcgggacgg agtcccttgg atcccatgac      420

cagcccagga tccgggctaa ttctccaagc aaattttgtc cacagtcaac gacgggagtc      480

cttcctgtat cgatccgaca gcgattatga cctctctcca aagtctatgt cccggaactc      540

ctccattgcc agtgatatac acggagatga cttgattgtg actccatttg ctcaggtctt      600

ggccagtctg cgaactgtac gaaacaactt tgctgcatta actaatttgc aagatcgagc      660

acctagcaaa agatcaccca tgtgcaacca accatccatc aacaaagcca ccataacaga      720

ggaggcctac cagaaactgg ccagcgagac cctggaggag ctggactggt gtctggacca      780

gctagagacc ctacagacca ggcactccgt cagtgagatg gcctccaaca agtttaaaag      840

gatgcttaat cgggagctca cccatctctc tgaaatgagt cggtctggaa atcaagtgtc      900

agagtttata tcaaacacat tcttagataa gcaacatgaa gtggaaattc cttctccaac      960

tcagaaggaa aaggagaaaa agaaaagacc aatgtctcag atcagtggag tcaagaaatt     1020

gatgcacagc tctagtctga ctaattcaag tatcccaagg tttggagtta aaactgaaca     1080

agaagatgtc cttgccaagg aactagaaga tgtgaacaaa tggggtcttc atgttttcag     1140

aatagcagag ttgtctggta accggccctt gactgttatc atgcacacca tttttcagga     1200

acgggattta ttaaaaacat ttaaaattcc agtagatact ttaattacat atcttatgac     1260

tctcgaagac cattaccatg ctgatgtggc ctatcacaac aatatccatg ctgcagatgt     1320

tgtccagtct actcatgtgc tattatctac acctgctttg gaggctgtgt ttacagattt     1380

ggagattctt gcagcaattt ttgccagtgc aatacatgat gtagatcatc ctggtgtgtc     1440

caatcaattt ctgatcaata caaactctga acttgccttg atgtacaatg attcctcagt     1500

cttagagaac catcatttgg ctgtgggctt taaattgctt caggaagaaa actgtgacat     1560

tttccagaat ttgaccaaaa aacaaagaca atctttaagg aaaatggtca ttgacatcgt     1620

acttgcaaca gatatgtcaa aacacatgaa tctactggct gatttgaaga ctatggttga     1680

aactaagaaa gtgacaagct ctggagttct tcttcttgat aattattccg ataggattca     1740

ggttcttcag aatatggtgc actgtgcaga tctgagcaac ccaacaaagc ctctccagct     1800

gtaccgccag tggacggacc ggataatgga ggagttcttc cgccaaggag accgagagag     1860

ggaacgtggc atggagataa gccccatgtg tgacaagcac aatgcttccg tggaaaaatc     1920

acaggtgggc ttcatagact atattgttca tcccctctgg gagacatggg cagacctcgt     1980

ccaccctgac gcccaggata ttttggacac tttggaggac aatcgtgaat ggtaccagag     2040

cacaatccct cagagcccct ctcctgcacc tgatgaccca gaggagggcc ggcagggtca     2100

aactgagaaa ttccagtttg aactaacttt agaggaagat ggtgagtcag acacggaaaa     2160

ggacagtggc agtcaagtgg aagaagacac tagctgcagt gactccaaga ctctttgtac     2220

tcaagactca gagtctactg aaattcccct tgatgaacag gttgaagagg aggcagtagg     2280

ggaagaagag gaaagccagc ctgaagcctg tgtcatagat gatcgttctc ctgacacgta     2340

acagtgcaaa aactttcatg cctttttttt ttttaagtag aaaaattgtt tccaaagtgc     2400

atgtcacatg ccacaaccac ggtcacacct cactgtcatc tgccaggacg tttgttgaac     2460

aaaactgacc ttgactactc agtccagcgc tcaggaatat cgtaaccagt tttttcacct     2520

ccatgtcatc cgagcaaggt ggacatcttc acgaacagcg tttttaacaa gatttcagct     2580

tggtagagct gacaaagcag ataaaatcta ctccaaatta ttttcaagag agtgtgactc     2640

atcaggcagc ccaaaagttt attggacttg gggtttctat tcctttttat ttgtttgcaa     2700

tattttcaga agaaaggcat tgcacagagt gaacttaatg gacgaagcaa caaatatgtc     2760

aagaacagga catagcacga atctgttacc agtaggagga ggatgagcca cagaaattgc     2820

ataattttct aatttcaagt cttcctgata catgactgaa tagtgtggtt cagtgagctg     2880

cactgacctc tacattttgt atgatatgta aaacagattt tttgtagagc ttacttttat     2940

tattaaatgt attgaggtat tatatttaaa aaaaactatg ttcagaactt catctgccac     3000

tggttatttt tttctaagga gtaacttgca agttttcagt acaaatctgt gctacactgg     3060

ataaaaatct aatttatgaa ttttacttgc accttatagt tcatagcaat taactgattt     3120

gtagtgattc attgtttgtt ttatatacca atgacttcca tattttaaaa gagaaaaaca     3180

actttatgtt gcaggaaacc ctttttgtaa gtctttatta tttactttgc attttgtttc     3240

actctttcca gataagcaga gttgctcttc accagtgttt ttcttcatgt gcaaagtgac     3300

tatttgttct ataatacttt tatgtgtgtt atatcaaatg tgtcttaagc ttcatgcaaa     3360

ctcagtcatc agttcgtgtt gtctgaagca agtgggagat atataaatac ccagtagcta     3420

aaatggtcag tcttttttag atgttttcct acttagtatc tcctaataac gttttgctgt     3480

gtcactagat gttcatttca caagtgcatg tctttctaat aatccacaca tttcatgctc     3540

taataatcca cacatttcat gctcattttt attgttttta cagccagtta tagtaagaaa     3600

aaggtttttc cccttgtgct gctttataat ttagcgtgtg tctgaacctt atccatgttt     3660

gctagatgag gtcttgtcaa atatatcact accattgtca ccggtgaaaa gaaacaggta     3720

gttaagttag ggttaacatt catttcaacc acgaggttgt atatcatgac tagcttttac     3780

tcttggttta cagagaaaag ttaaacagcc aactaggcag tttttaagaa tattaacaat     3840

atattaacaa acaccaatac aactaatcct atttggtttt aatgatttca ccatgggatt     3900

aagaactata tcaggaacat ccctgagaaa cggttttaag tgtagcaact actcttcctt     3960

aatggacagc cacataacgt gtaggaagtc ctttatcact tatcctcgat ccataagcat     4020

atcttgcaga ggggaactac ttctttaaac acatggaggg aaagaagatg atgccactgg     4080

caccagaggg ttagtactgt gatgcatcct aaaatattta ttatattggt aaaaattctg     4140

gttaaataaa aaattagaga tcactcttgg ctgatttcag caccaggaac tgtattacag     4200

ttttagagat taattcctag tgtttacctg attatagcag ttggcatcat ggggcattta     4260

attctgactt tatccccacg tcagccttaa taaagtcttc tttaccttct ctatgaagac     4320

tttaaagccc aaataatcat ttttcacatt gatattcaag aattgagata gatagaagcc     4380

aaagtgggta tctgacaagt ggaaaatcaa acgtttaaga agaattacaa ctctgaaaag     4440

catttatatg tggaacttct caaggagcct cctggggact ggaaagtaag tcatcagcca     4500

ggcaaatgac tcatgctgaa gagagtcccc atttcagtcc cctgagatct agctgatgct     4560

tagatccttt gaaataaaaa ttatgtcttt ataactctga tcttttacat aaagcagaag     4620

aggaatcaac tagttaattg caaggtttct actctgtttc ctctgtaaag atcagatggt     4680

aatctttcaa ataagaaaaa aataaagacg tatgtttgac caagtagttt cacaagaata     4740

tttgggaact tgtttctttt aattttattt gtccctgagt gaagtctaga aagaaaggta     4800

aagagtctag agtttattcc tctttccaaa acattctcat tcctctcctc cctacactta     4860

gtatttcccc cacagagtgc ctagaatctt aataatgaat aaaataaaaa gcagcaatat     4920

gtcattaaca aatccagacc tgaaagggta aagggtttat aactgcacta ataaagagag     4980

gctctttttt tttcttccag tttgttggtt tttaatggta ccgtgttgta aagataccca     5040

ctaatggaca atcaaattgc agaaaaggct caatatccaa gagacaggga ctaatgcact     5100

gtacaatctg cttatccttg cccttctctc ttgccaaagt gtgcttcaga aatatatact     5160

gctttaaaaa agaataaaag aatatccttt tacaagtggc tttacatttc ctaaaatgcc     5220

ataagaaaat gcaatatctg ggtactgtat ggggaaaaaa atgtccaagt ttgtgtaaaa     5280

ccagtgcatt tcagcttgca agttactgaa cacaataatg ctgttttaat tttgttttat     5340

atcagttaaa attcacaata atgtagatag aacaaattac agacaaggaa agaaaaaact     5400

tgaatgaaat ggattttaca gaaagcttta tgataatttt tgaatgcatt atttattttt     5460

tgtgccatgc attttttttc tcaccaaatg accttacctg taatacagtc ttgtttgtct     5520

gtttacaacc atgtatttat tgcaatgtac atactgtaat gttaattgta aattatctgt     5580

tcttattaaa acatcatccc atgatgggat ggtgttgata tatttggaaa ctcttggtga     5640

gagaatgaat ggtgtgtata catactctgt acatttttct tttctcctgt aatatagtct     5700

tgtcacctta gagcttgttt atggaagatt caagaaaact ataaaatact taaagatata     5760

taaatttaaa aaaacatagc tgcaggtctt tggtcccagg gctgtgcctt aactttaacc     5820

aatattttct tctgttttgc tgcatttgaa aggtaacagt ggagctaggg ctgggcattt     5880

tacatccagg cttttaattg attagaattc tgccaatagg tggattttac aaaaccacag     5940

acaacctctg aaagattctg agaccctttt gagacagaag ctcttaagta cttcttgcca     6000

gggagcagca ctgcatgtgt gatggttgtt tgccatctgt tgatcaggaa ctacttcagc     6060

tacttgcatt tgattatttc cttttttttt ttttttaact cggaaacaca actggggaaa     6120

tatattcttt cccagtgatt ataaacaatc tttttctttt ttttaagtcc ttttggcttc     6180

tagagctcat aggaaaatgg acttgatttg aaattggagc cagagtttac tcgtgttggt     6240

tatctattca tcagcttcct gacatgttaa gagaatacat taaagagaaa atactgtttt     6300

ttaatcctaa aatttttctt ccactaagat aaaccaaatg tccttacata tatgtaaacc     6360

catctattta aacgcaaagg tgggttgatg tcagtttaca tagcagaaag cattcactat     6420

cctctaagat ttgtttctgc aaaactttca ttgctttaga attttaaaat ttcaccttgt     6480

acaatggcca gcccctaaag caggaaacat ttataatgga ttatatggaa acatcctccc     6540

agtacttgcc cagcccttga atcatgtggc ttttcagtga aaggaaagat tctttttcta     6600

ggaaaaatga gcctatttta ttttatttta ttttattttt tgacacaaac tgtagatttt     6660

agcagccctg gcccaaagga atttgattac ttttgtttta aacagtacaa aggggacact     6720

ataattacaa aaacatcctt aactgatttg agttgttttt atttctttgg atatattttc     6780

agagtggtaa attgtgtgtg agaattacaa atgattattc ttttagtggt ttcttagcct     6840

ctcttacagc ccacggggat agtactgtac atcaatacct tcatatgaaa tttttatatg     6900

caatgaaaat aaaagcatgg gttgattctg cctatttatg actcaatctt ttacaaataa     6960

aagattattc attttaaatt atagttcaat cagcatgtct cttaggatac tgaacgtggt     7020

tgaaatgaaa ggatagtgac atcataagtt agtactgata ttcataacca aataaagcca     7080

acttgagtaa ttttgctaca ttaaaaatta ccaaaattac ttagatggcc tataagatta     7140

agcatggtgt tttctaagca agctttgaaa ggggccttcc atacttactt aattgaatat     7200

tctgggatat tgaaaattat tcagatactt gacaattatt tttggttacc tactccgcaa     7260

actacaaagt tttaaggact caacaataag ttaatgagac acagtgtttg ctttcatgga     7320

gcttacagtc tggaggggac aaaggcttaa acaatactca tataattata tatgtgatca     7380

gtacaatgaa ggagctcagt ggggtaaata agcaggaacc tgaacttgat ctgttccgga     7440

gggccacaga aggcttcctt gaggccttga gaaagtgatt tgcatctgag ttctgaagga     7500

ttgtaagagg taactaggga aaaagttgac aggaagagga aggggatcca gacaagaaac     7560

atttgcaaag atcttgaggc ataaatgagc ttgagacatc tggagaaact gaggaaaagt     7620

gagagagtag gcagggcctg gagccgcaga gccattgcta accatcctgt gtgagatatc     7680

ccccattctg tagctttatt ctcataaccc tgctcaattt tctttataac acttctcaca     7740

gatttatata cgtgtttgtt tttgttatct gtctctccca ccagaccaca gctccatgag     7800

agcaaggtct ttgcttacca atatatcact agcacttaaa actatgcctg gtacacagta     7860

ggttcttaat atgtgttgaa tatagccatc aaattgatat tggatataat tcaatctgat     7920

aagatatttt gagatattaa agagttttta acttgatacc ataaaaaaaa aaaaaaaaa      7979


<210>  13
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
        195                 200                 205             


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
    210                 215                 220                 


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
225                 230                 235                 240 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
                245                 250                 255     


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
            260                 265                 270         


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
        275                 280                 285             


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
    290                 295                 300                 


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
305                 310                 315                 320 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
                325                 330                 335     


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
            340                 345                 350         


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
        355                 360                 365             


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
    370                 375                 380                 


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
385                 390                 395                 400 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
                405                 410                 415     


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
            420                 425                 430         


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
        435                 440                 445             


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
    450                 455                 460                 


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
465                 470                 475                 480 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
                485                 490                 495     


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
            500                 505                 510         


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
        515                 520                 525             


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
    530                 535                 540                 


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
545                 550                 555                 560 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
                565                 570                 575     


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
            580                 585                 590         


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
        595                 600                 605             


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
    610                 615                 620                 


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
625                 630                 635                 640 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
                645                 650                 655     


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
            660                 665                 670         


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
        675                 680                 685             


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
    690                 695                 700                 


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
705                 710                 715                 720 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
                725                 730                 735     


Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745 


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D5_forward primer

<400>  14
gcttctcagc agcaacatc                                                    19


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D5_reverse primer

<400>  15
tgccattgtc cacatcaaaa                                                   20


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D5 probe

<400>  16
acagcggcgt ttcacggtgg caca                                              24


<210>  17
<211>  7591
<212>  DNA
<213>  Homo sapiens

<400>  17
agttccttat ttggtagctt ttgacaggac tagcctttct tgcaactaag catcttgaca       60

tacattattc attaagccct ggagctcggg agagaaagat gcagaccctt agatctttag      120

atattccttt atcacgtgga ttttctttat tcagaatagt tgctgaattt tgtgccattc      180

tggagtctta caaatggcat gtattcgatg ggaagacggc tggatgggat ttaatgcgag      240

gctttcttat gtatacttaa ttaccaaaaa tctttaaaaa ctcatactct gcgtggcttg      300

tggaggttgt taaagtgtcg agattttgaa gctaaataca ttttagagct tactatatat      360

atacatatat atatatatac atataatcaa tcaaaaatgc ctgaagcaaa ctatttactg      420

tcagtgtctt ggggctacat aaagtttaaa aggatgctta atcgggagct cacccatctc      480

tctgaaatga gtcggtctgg aaatcaagtg tcagagttta tatcaaacac attcttagat      540

aagcaacatg aagtggaaat tccttctcca actcagaagg aaaaggagaa aaagaaaaga      600

ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca gctctagtct gactaattca      660

agtatcccaa ggtttggagt taaaactgaa caagaagatg tccttgccaa ggaactagaa      720

gatgtgaaca aatggggtct tcatgttttc agaatagcag agttgtctgg taaccggccc      780

ttgactgtta tcatgcacac catttttcag gaacgggatt tattaaaaac atttaaaatt      840

ccagtagata ctttaattac atatcttatg actctcgaag accattacca tgctgatgtg      900

gcctatcaca acaatatcca tgctgcagat gttgtccagt ctactcatgt gctattatct      960

acacctgctt tggaggctgt gtttacagat ttggagattc ttgcagcaat ttttgccagt     1020

gcaatacatg atgtagatca tcctggtgtg tccaatcaat ttctgatcaa tacaaactct     1080

gaacttgcct tgatgtacaa tgattcctca gtcttagaga accatcattt ggctgtgggc     1140

tttaaattgc ttcaggaaga aaactgtgac attttccaga atttgaccaa aaaacaaaga     1200

caatctttaa ggaaaatggt cattgacatc gtacttgcaa cagatatgtc aaaacacatg     1260

aatctactgg ctgatttgaa gactatggtt gaaactaaga aagtgacaag ctctggagtt     1320

cttcttcttg ataattattc cgataggatt caggttcttc agaatatggt gcactgtgca     1380

gatctgagca acccaacaaa gcctctccag ctgtaccgcc agtggacgga ccggataatg     1440

gaggagttct tccgccaagg agaccgagag agggaacgtg gcatggagat aagccccatg     1500

tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg gcttcataga ctatattgtt     1560

catcccctct gggagacatg ggcagacctc gtccaccctg acgcccagga tattttggac     1620

actttggagg acaatcgtga atggtaccag agcacaatcc ctcagagccc ctctcctgca     1680

cctgatgacc cagaggaggg ccggcagggt caaactgaga aattccagtt tgaactaact     1740

ttagaggaag atggtgagtc agacacggaa aaggacagtg gcagtcaagt ggaagaagac     1800

actagctgca gtgactccaa gactctttgt actcaagact cagagtctac tgaaattccc     1860

cttgatgaac aggttgaaga ggaggcagta ggggaagaag aggaaagcca gcctgaagcc     1920

tgtgtcatag atgatcgttc tcctgacacg taacagtgca aaaactttca tgcctttttt     1980

ttttttaagt agaaaaattg tttccaaagt gcatgtcaca tgccacaacc acggtcacac     2040

ctcactgtca tctgccagga cgtttgttga acaaaactga ccttgactac tcagtccagc     2100

gctcaggaat atcgtaacca gttttttcac ctccatgtca tccgagcaag gtggacatct     2160

tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc     2220

tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact     2280

tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga     2340

gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta     2400

ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga     2460

tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg     2520

taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta     2580

aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg     2640

caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt     2700

gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac     2760

caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt     2820

aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct     2880

tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatact tttatgtgtg     2940

ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca tcagttcgtg ttgtctgaag     3000

caagtgggag atatataaat acccagtagc taaaatggtc agtctttttt agatgttttc     3060

ctacttagta tctcctaata acgttttgct gtgtcactag atgttcattt cacaagtgca     3120

tgtctttcta ataatccaca catttcatgc tctaataatc cacacatttc atgctcattt     3180

ttattgtttt tacagccagt tatagtaaga aaaaggtttt tccccttgtg ctgctttata     3240

atttagcgtg tgtctgaacc ttatccatgt ttgctagatg aggtcttgtc aaatatatca     3300

ctaccattgt caccggtgaa aagaaacagg tagttaagtt agggttaaca ttcatttcaa     3360

ccacgaggtt gtatatcatg actagctttt actcttggtt tacagagaaa agttaaacag     3420

ccaactaggc agtttttaag aatattaaca atatattaac aaacaccaat acaactaatc     3480

ctatttggtt ttaatgattt caccatggga ttaagaacta tatcaggaac atccctgaga     3540

aacggtttta agtgtagcaa ctactcttcc ttaatggaca gccacataac gtgtaggaag     3600

tcctttatca cttatcctcg atccataagc atatcttgca gaggggaact acttctttaa     3660

acacatggag ggaaagaaga tgatgccact ggcaccagag ggttagtact gtgatgcatc     3720

ctaaaatatt tattatattg gtaaaaattc tggttaaata aaaaattaga gatcactctt     3780

ggctgatttc agcaccagga actgtattac agttttagag attaattcct agtgtttacc     3840

tgattatagc agttggcatc atggggcatt taattctgac tttatcccca cgtcagcctt     3900

aataaagtct tctttacctt ctctatgaag actttaaagc ccaaataatc atttttcaca     3960

ttgatattca agaattgaga tagatagaag ccaaagtggg tatctgacaa gtggaaaatc     4020

aaacgtttaa gaagaattac aactctgaaa agcatttata tgtggaactt ctcaaggagc     4080

ctcctgggga ctggaaagta agtcatcagc caggcaaatg actcatgctg aagagagtcc     4140

ccatttcagt cccctgagat ctagctgatg cttagatcct ttgaaataaa aattatgtct     4200

ttataactct gatcttttac ataaagcaga agaggaatca actagttaat tgcaaggttt     4260

ctactctgtt tcctctgtaa agatcagatg gtaatctttc aaataagaaa aaaataaaga     4320

cgtatgtttg accaagtagt ttcacaagaa tatttgggaa cttgtttctt ttaattttat     4380

ttgtccctga gtgaagtcta gaaagaaagg taaagagtct agagtttatt cctctttcca     4440

aaacattctc attcctctcc tccctacact tagtatttcc cccacagagt gcctagaatc     4500

ttaataatga ataaaataaa aagcagcaat atgtcattaa caaatccaga cctgaaaggg     4560

taaagggttt ataactgcac taataaagag aggctctttt tttttcttcc agtttgttgg     4620

tttttaatgg taccgtgttg taaagatacc cactaatgga caatcaaatt gcagaaaagg     4680

ctcaatatcc aagagacagg gactaatgca ctgtacaatc tgcttatcct tgcccttctc     4740

tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa aaagaataaa agaatatcct     4800

tttacaagtg gctttacatt tcctaaaatg ccataagaaa atgcaatatc tgggtactgt     4860

atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca tttcagcttg caagttactg     4920

aacacaataa tgctgtttta attttgtttt atatcagtta aaattcacaa taatgtagat     4980

agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa atggatttta cagaaagctt     5040

tatgataatt tttgaatgca ttatttattt tttgtgccat gcattttttt tctcaccaaa     5100

tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa ccatgtattt attgcaatgt     5160

acatactgta atgttaattg taaattatct gttcttatta aaacatcatc ccatgatggg     5220

atggtgttga tatatttgga aactcttggt gagagaatga atggtgtgta tacatactct     5280

gtacattttt cttttctcct gtaatatagt cttgtcacct tagagcttgt ttatggaaga     5340

ttcaagaaaa ctataaaata cttaaagata tataaattta aaaaaacata gctgcaggtc     5400

tttggtccca gggctgtgcc ttaactttaa ccaatatttt cttctgtttt gctgcatttg     5460

aaaggtaaca gtggagctag ggctgggcat tttacatcca ggcttttaat tgattagaat     5520

tctgccaata ggtggatttt acaaaaccac agacaacctc tgaaagattc tgagaccctt     5580

ttgagacaga agctcttaag tacttcttgc cagggagcag cactgcatgt gtgatggttg     5640

tttgccatct gttgatcagg aactacttca gctacttgca tttgattatt tccttttttt     5700

ttttttttaa ctcggaaaca caactgggga aatatattct ttcccagtga ttataaacaa     5760

tctttttctt ttttttaagt ccttttggct tctagagctc ataggaaaat ggacttgatt     5820

tgaaattgga gccagagttt actcgtgttg gttatctatt catcagcttc ctgacatgtt     5880

aagagaatac attaaagaga aaatactgtt ttttaatcct aaaatttttc ttccactaag     5940

ataaaccaaa tgtccttaca tatatgtaaa cccatctatt taaacgcaaa ggtgggttga     6000

tgtcagttta catagcagaa agcattcact atcctctaag atttgtttct gcaaaacttt     6060

cattgcttta gaattttaaa atttcacctt gtacaatggc cagcccctaa agcaggaaac     6120

atttataatg gattatatgg aaacatcctc ccagtacttg cccagccctt gaatcatgtg     6180

gcttttcagt gaaaggaaag attctttttc taggaaaaat gagcctattt tattttattt     6240

tattttattt tttgacacaa actgtagatt ttagcagccc tggcccaaag gaatttgatt     6300

acttttgttt taaacagtac aaaggggaca ctataattac aaaaacatcc ttaactgatt     6360

tgagttgttt ttatttcttt ggatatattt tcagagtggt aaattgtgtg tgagaattac     6420

aaatgattat tcttttagtg gtttcttagc ctctcttaca gcccacgggg atagtactgt     6480

acatcaatac cttcatatga aatttttata tgcaatgaaa ataaaagcat gggttgattc     6540

tgcctattta tgactcaatc ttttacaaat aaaagattat tcattttaaa ttatagttca     6600

atcagcatgt ctcttaggat actgaacgtg gttgaaatga aaggatagtg acatcataag     6660

ttagtactga tattcataac caaataaagc caacttgagt aattttgcta cattaaaaat     6720

taccaaaatt acttagatgg cctataagat taagcatggt gttttctaag caagctttga     6780

aaggggcctt ccatacttac ttaattgaat attctgggat attgaaaatt attcagatac     6840

ttgacaatta tttttggtta cctactccgc aaactacaaa gttttaagga ctcaacaata     6900

agttaatgag acacagtgtt tgctttcatg gagcttacag tctggagggg acaaaggctt     6960

aaacaatact catataatta tatatgtgat cagtacaatg aaggagctca gtggggtaaa     7020

taagcaggaa cctgaacttg atctgttccg gagggccaca gaaggcttcc ttgaggcctt     7080

gagaaagtga tttgcatctg agttctgaag gattgtaaga ggtaactagg gaaaaagttg     7140

acaggaagag gaaggggatc cagacaagaa acatttgcaa agatcttgag gcataaatga     7200

gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt aggcagggcc tggagccgca     7260

gagccattgc taaccatcct gtgtgagata tcccccattc tgtagcttta ttctcataac     7320

cctgctcaat tttctttata acacttctca cagatttata tacgtgtttg tttttgttat     7380

ctgtctctcc caccagacca cagctccatg agagcaaggt ctttgcttac caatatatca     7440

ctagcactta aaactatgcc tggtacacag taggttctta atatgtgttg aatatagcca     7500

tcaaattgat attggatata attcaatctg ataagatatt ttgagatatt aaagagtttt     7560

taacttgata ccataaaaaa aaaaaaaaaa a                                    7591


<210>  18
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Glu Ala Asn Tyr Leu Leu Ser Val Ser Trp Gly Tyr Ile Lys 
1               5                   10                  15      


Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser 
            20                  25                  30          


Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp 
        35                  40                  45              


Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu 
    50                  55                  60                  


Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met 
65                  70                  75                  80  


His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys 
                85                  90                  95      


Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys 
            100                 105                 110         


Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro 
        115                 120                 125             


Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys 
    130                 135                 140                 


Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu 
145                 150                 155                 160 


Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His Ala 
                165                 170                 175     


Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu 
            180                 185                 190         


Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser 
        195                 200                 205             


Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile 
    210                 215                 220                 


Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu 
225                 230                 235                 240 


Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn 
                245                 250                 255     


Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg 
            260                 265                 270         


Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His Met 
        275                 280                 285             


Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr 
    290                 295                 300                 


Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val 
305                 310                 315                 320 


Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro 
                325                 330                 335     


Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe 
            340                 345                 350         


Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met 
        355                 360                 365             


Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile 
    370                 375                 380                 


Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His 
385                 390                 395                 400 


Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp 
                405                 410                 415     


Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro 
            420                 425                 430         


Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr 
        435                 440                 445             


Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln 
    450                 455                 460                 


Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln 
465                 470                 475                 480 


Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu 
                485                 490                 495     


Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp 
            500                 505                 510         


Asp Arg Ser Pro Asp Thr 
        515             


<210>  19
<211>  8130
<212>  DNA
<213>  Homo sapiens

<400>  19
agattatagc ccagcgtacg agaagcacga gtcctatagt tggcgtaccc tgaggcctgc       60

cagttcctgc cttaatgcat atgtagtcgt aattgagttc tgacacggcc ttggatgttt      120

ctgtcctaaa tagctgacat tgcatcttca agactgtcat tccagttggc ttttgagtgg      180

atacgtgcag tgagatcatt gacactggaa acactagttc ccattttaat tacttaaaac      240

accacgatga aaagaaatac ctgtgatttg ctttctcgga gcaaaagtgc ctctgaggaa      300

acactacatt ccagtaatga agaggaagac cctttccgcg gaatggaacc ctatcttgtc      360

cggagacttt catgtcgcaa tattcagctt ccccctctcg ccttcagaca gttggaacaa      420

gctgacttga aaagtgaatc agagaacatt caacgaccaa ccagcctccc cctgaagatt      480

ctgccgctga ttgctatcac ttctgcagaa tccagtggtt ttgatgtgga caatggcaca      540

tctgcgggac ggagtccctt ggatcccatg accagcccag gatccgggct aattctccaa      600

gcaaattttg tccacagtca acgacgggag tccttcctgt atcgatccga cagcgattat      660

gacctctctc caaagtctat gtcccggaac tcctccattg ccagtgatat acacggagat      720

gacttgattg tgactccatt tgctcaggtc ttggccagtc tgcgaactgt acgaaacaac      780

tttgctgcat taactaattt gcaagatcga gcacctagca aaagatcacc catgtgcaac      840

caaccatcca tcaacaaagc caccataaca gaggaggcct accagaaact ggccagcgag      900

accctggagg agctggactg gtgtctggac cagctagaga ccctacagac caggcactcc      960

gtcagtgaga tggcctccaa caagtttaaa aggatgctta atcgggagct cacccatctc     1020

tctgaaatga gtcggtctgg aaatcaagtg tcagagttta tatcaaacac attcttagat     1080

aagcaacatg aagtggaaat tccttctcca actcagaagg aaaaggagaa aaagaaaaga     1140

ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca gctctagtct gactaattca     1200

agtatcccaa ggtttggagt taaaactgaa caagaagatg tccttgccaa ggaactagaa     1260

gatgtgaaca aatggggtct tcatgttttc agaatagcag agttgtctgg taaccggccc     1320

ttgactgtta tcatgcacac catttttcag gaacgggatt tattaaaaac atttaaaatt     1380

ccagtagata ctttaattac atatcttatg actctcgaag accattacca tgctgatgtg     1440

gcctatcaca acaatatcca tgctgcagat gttgtccagt ctactcatgt gctattatct     1500

acacctgctt tggaggctgt gtttacagat ttggagattc ttgcagcaat ttttgccagt     1560

gcaatacatg atgtagatca tcctggtgtg tccaatcaat ttctgatcaa tacaaactct     1620

gaacttgcct tgatgtacaa tgattcctca gtcttagaga accatcattt ggctgtgggc     1680

tttaaattgc ttcaggaaga aaactgtgac attttccaga atttgaccaa aaaacaaaga     1740

caatctttaa ggaaaatggt cattgacatc gtacttgcaa cagatatgtc aaaacacatg     1800

aatctactgg ctgatttgaa gactatggtt gaaactaaga aagtgacaag ctctggagtt     1860

cttcttcttg ataattattc cgataggatt caggttcttc agaatatggt gcactgtgca     1920

gatctgagca acccaacaaa gcctctccag ctgtaccgcc agtggacgga ccggataatg     1980

gaggagttct tccgccaagg agaccgagag agggaacgtg gcatggagat aagccccatg     2040

tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg gcttcataga ctatattgtt     2100

catcccctct gggagacatg ggcagacctc gtccaccctg acgcccagga tattttggac     2160

actttggagg acaatcgtga atggtaccag agcacaatcc ctcagagccc ctctcctgca     2220

cctgatgacc cagaggaggg ccggcagggt caaactgaga aattccagtt tgaactaact     2280

ttagaggaag atggtgagtc agacacggaa aaggacagtg gcagtcaagt ggaagaagac     2340

actagctgca gtgactccaa gactctttgt actcaagact cagagtctac tgaaattccc     2400

cttgatgaac aggttgaaga ggaggcagta ggggaagaag aggaaagcca gcctgaagcc     2460

tgtgtcatag atgatcgttc tcctgacacg taacagtgca aaaactttca tgcctttttt     2520

ttttttaagt agaaaaattg tttccaaagt gcatgtcaca tgccacaacc acggtcacac     2580

ctcactgtca tctgccagga cgtttgttga acaaaactga ccttgactac tcagtccagc     2640

gctcaggaat atcgtaacca gttttttcac ctccatgtca tccgagcaag gtggacatct     2700

tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc     2760

tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact     2820

tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga     2880

gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta     2940

ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga     3000

tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg     3060

taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta     3120

aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg     3180

caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt     3240

gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac     3300

caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt     3360

aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct     3420

tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatact tttatgtgtg     3480

ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca tcagttcgtg ttgtctgaag     3540

caagtgggag atatataaat acccagtagc taaaatggtc agtctttttt agatgttttc     3600

ctacttagta tctcctaata acgttttgct gtgtcactag atgttcattt cacaagtgca     3660

tgtctttcta ataatccaca catttcatgc tctaataatc cacacatttc atgctcattt     3720

ttattgtttt tacagccagt tatagtaaga aaaaggtttt tccccttgtg ctgctttata     3780

atttagcgtg tgtctgaacc ttatccatgt ttgctagatg aggtcttgtc aaatatatca     3840

ctaccattgt caccggtgaa aagaaacagg tagttaagtt agggttaaca ttcatttcaa     3900

ccacgaggtt gtatatcatg actagctttt actcttggtt tacagagaaa agttaaacag     3960

ccaactaggc agtttttaag aatattaaca atatattaac aaacaccaat acaactaatc     4020

ctatttggtt ttaatgattt caccatggga ttaagaacta tatcaggaac atccctgaga     4080

aacggtttta agtgtagcaa ctactcttcc ttaatggaca gccacataac gtgtaggaag     4140

tcctttatca cttatcctcg atccataagc atatcttgca gaggggaact acttctttaa     4200

acacatggag ggaaagaaga tgatgccact ggcaccagag ggttagtact gtgatgcatc     4260

ctaaaatatt tattatattg gtaaaaattc tggttaaata aaaaattaga gatcactctt     4320

ggctgatttc agcaccagga actgtattac agttttagag attaattcct agtgtttacc     4380

tgattatagc agttggcatc atggggcatt taattctgac tttatcccca cgtcagcctt     4440

aataaagtct tctttacctt ctctatgaag actttaaagc ccaaataatc atttttcaca     4500

ttgatattca agaattgaga tagatagaag ccaaagtggg tatctgacaa gtggaaaatc     4560

aaacgtttaa gaagaattac aactctgaaa agcatttata tgtggaactt ctcaaggagc     4620

ctcctgggga ctggaaagta agtcatcagc caggcaaatg actcatgctg aagagagtcc     4680

ccatttcagt cccctgagat ctagctgatg cttagatcct ttgaaataaa aattatgtct     4740

ttataactct gatcttttac ataaagcaga agaggaatca actagttaat tgcaaggttt     4800

ctactctgtt tcctctgtaa agatcagatg gtaatctttc aaataagaaa aaaataaaga     4860

cgtatgtttg accaagtagt ttcacaagaa tatttgggaa cttgtttctt ttaattttat     4920

ttgtccctga gtgaagtcta gaaagaaagg taaagagtct agagtttatt cctctttcca     4980

aaacattctc attcctctcc tccctacact tagtatttcc cccacagagt gcctagaatc     5040

ttaataatga ataaaataaa aagcagcaat atgtcattaa caaatccaga cctgaaaggg     5100

taaagggttt ataactgcac taataaagag aggctctttt tttttcttcc agtttgttgg     5160

tttttaatgg taccgtgttg taaagatacc cactaatgga caatcaaatt gcagaaaagg     5220

ctcaatatcc aagagacagg gactaatgca ctgtacaatc tgcttatcct tgcccttctc     5280

tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa aaagaataaa agaatatcct     5340

tttacaagtg gctttacatt tcctaaaatg ccataagaaa atgcaatatc tgggtactgt     5400

atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca tttcagcttg caagttactg     5460

aacacaataa tgctgtttta attttgtttt atatcagtta aaattcacaa taatgtagat     5520

agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa atggatttta cagaaagctt     5580

tatgataatt tttgaatgca ttatttattt tttgtgccat gcattttttt tctcaccaaa     5640

tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa ccatgtattt attgcaatgt     5700

acatactgta atgttaattg taaattatct gttcttatta aaacatcatc ccatgatggg     5760

atggtgttga tatatttgga aactcttggt gagagaatga atggtgtgta tacatactct     5820

gtacattttt cttttctcct gtaatatagt cttgtcacct tagagcttgt ttatggaaga     5880

ttcaagaaaa ctataaaata cttaaagata tataaattta aaaaaacata gctgcaggtc     5940

tttggtccca gggctgtgcc ttaactttaa ccaatatttt cttctgtttt gctgcatttg     6000

aaaggtaaca gtggagctag ggctgggcat tttacatcca ggcttttaat tgattagaat     6060

tctgccaata ggtggatttt acaaaaccac agacaacctc tgaaagattc tgagaccctt     6120

ttgagacaga agctcttaag tacttcttgc cagggagcag cactgcatgt gtgatggttg     6180

tttgccatct gttgatcagg aactacttca gctacttgca tttgattatt tccttttttt     6240

ttttttttaa ctcggaaaca caactgggga aatatattct ttcccagtga ttataaacaa     6300

tctttttctt ttttttaagt ccttttggct tctagagctc ataggaaaat ggacttgatt     6360

tgaaattgga gccagagttt actcgtgttg gttatctatt catcagcttc ctgacatgtt     6420

aagagaatac attaaagaga aaatactgtt ttttaatcct aaaatttttc ttccactaag     6480

ataaaccaaa tgtccttaca tatatgtaaa cccatctatt taaacgcaaa ggtgggttga     6540

tgtcagttta catagcagaa agcattcact atcctctaag atttgtttct gcaaaacttt     6600

cattgcttta gaattttaaa atttcacctt gtacaatggc cagcccctaa agcaggaaac     6660

atttataatg gattatatgg aaacatcctc ccagtacttg cccagccctt gaatcatgtg     6720

gcttttcagt gaaaggaaag attctttttc taggaaaaat gagcctattt tattttattt     6780

tattttattt tttgacacaa actgtagatt ttagcagccc tggcccaaag gaatttgatt     6840

acttttgttt taaacagtac aaaggggaca ctataattac aaaaacatcc ttaactgatt     6900

tgagttgttt ttatttcttt ggatatattt tcagagtggt aaattgtgtg tgagaattac     6960

aaatgattat tcttttagtg gtttcttagc ctctcttaca gcccacgggg atagtactgt     7020

acatcaatac cttcatatga aatttttata tgcaatgaaa ataaaagcat gggttgattc     7080

tgcctattta tgactcaatc ttttacaaat aaaagattat tcattttaaa ttatagttca     7140

atcagcatgt ctcttaggat actgaacgtg gttgaaatga aaggatagtg acatcataag     7200

ttagtactga tattcataac caaataaagc caacttgagt aattttgcta cattaaaaat     7260

taccaaaatt acttagatgg cctataagat taagcatggt gttttctaag caagctttga     7320

aaggggcctt ccatacttac ttaattgaat attctgggat attgaaaatt attcagatac     7380

ttgacaatta tttttggtta cctactccgc aaactacaaa gttttaagga ctcaacaata     7440

agttaatgag acacagtgtt tgctttcatg gagcttacag tctggagggg acaaaggctt     7500

aaacaatact catataatta tatatgtgat cagtacaatg aaggagctca gtggggtaaa     7560

taagcaggaa cctgaacttg atctgttccg gagggccaca gaaggcttcc ttgaggcctt     7620

gagaaagtga tttgcatctg agttctgaag gattgtaaga ggtaactagg gaaaaagttg     7680

acaggaagag gaaggggatc cagacaagaa acatttgcaa agatcttgag gcataaatga     7740

gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt aggcagggcc tggagccgca     7800

gagccattgc taaccatcct gtgtgagata tcccccattc tgtagcttta ttctcataac     7860

cctgctcaat tttctttata acacttctca cagatttata tacgtgtttg tttttgttat     7920

ctgtctctcc caccagacca cagctccatg agagcaaggt ctttgcttac caatatatca     7980

ctagcactta aaactatgcc tggtacacag taggttctta atatgtgttg aatatagcca     8040

tcaaattgat attggatata attcaatctg ataagatatt ttgagatatt aaagagtttt     8100

taacttgata ccataaaaaa aaaaaaaaaa                                      8130


<210>  20
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Arg Asn Thr Cys Asp Leu Leu Ser Arg Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Glu Thr Leu His Ser Ser Asn Glu Glu Glu Asp Pro Phe Arg Gly 
            20                  25                  30          


Met Glu Pro Tyr Leu Val Arg Arg Leu Ser Cys Arg Asn Ile Gln Leu 
        35                  40                  45              


Pro Pro Leu Ala Phe Arg Gln Leu Glu Gln Ala Asp Leu Lys Ser Glu 
    50                  55                  60                  


Ser Glu Asn Ile Gln Arg Pro Thr Ser Leu Pro Leu Lys Ile Leu Pro 
65                  70                  75                  80  


Leu Ile Ala Ile Thr Ser Ala Glu Ser Ser Gly Phe Asp Val Asp Asn 
                85                  90                  95      


Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly 
            100                 105                 110         


Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu 
        115                 120                 125             


Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser 
    130                 135                 140                 


Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
145                 150                 155                 160 


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
                165                 170                 175     


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
            180                 185                 190         


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
        195                 200                 205             


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
    210                 215                 220                 


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
225                 230                 235                 240 


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
                245                 250                 255     


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
            260                 265                 270         


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
        275                 280                 285             


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
    290                 295                 300                 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
305                 310                 315                 320 


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
                325                 330                 335     


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
            340                 345                 350         


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
        355                 360                 365             


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
385                 390                 395                 400 


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
                405                 410                 415     


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
            420                 425                 430         


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
        435                 440                 445             


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
    450                 455                 460                 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
465                 470                 475                 480 


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
                485                 490                 495     


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
            500                 505                 510         


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
        515                 520                 525             


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
    530                 535                 540                 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
545                 550                 555                 560 


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
                565                 570                 575     


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
            580                 585                 590         


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
        595                 600                 605             


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
    610                 615                 620                 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
625                 630                 635                 640 


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
                645                 650                 655     


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
            660                 665                 670         


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
        675                 680                 685             


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
    690                 695                 700                 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
                725                 730                 735     


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745             


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7_forward primer

<400>  21
gaacattcaa cgaccaacca                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7_reverse primer

<400>  22
tgccattgtc cacatcaaaa                                                   20


<210>  23
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7 probe

<400>  23
ctgccgctga ttgctatcac ttctgca                                           27


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7 Forward Primer 2

<400>  24
cgctgattgc tatcacttct gc                                                22


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7 Reverse primer

<400>  25
gtcgttgact gtggacaaaa tttg                                              24


<210>  26
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7 Probe 2

<400>  26
ttcccttgga tcccatgacc agcccataag ggaa                                   34


<210>  27
<211>  8130
<212>  DNA
<213>  Homo sapiens

<400>  27
agattatagc ccagcgtacg agaagcacga gtcctatagt tggcgtaccc tgaggcctgc       60

cagttcctgc cttaatgcat atgtagtcgt aattgagttc tgacacggcc ttggatgttt      120

ctgtcctaaa tagctgacat tgcatcttca agactgtcat tccagttggc ttttgagtgg      180

atacgtgcag tgagatcatt gacactggaa acactagttc ccattttaat tacttaaaac      240

accacgatga aaagaaatac ctgtgatttg ctttctcgga gcaaaagtgc ctctgaggaa      300

acactacatt ccagtaatga agaggaagac cctttccgcg gaatggaacc ctatcttgtc      360

cggagacttt catgtcgcaa tattcagctt ccccctctcg ccttcagaca gttggaacaa      420

gctgacttga aaagtgaatc agagaacatt caacgaccaa ccagcctccc cctgaagatt      480

ctgccgctga ttgctatcac ttctgcagaa tccagtggtt ttgatgtgga caatggcaca      540

tctgcgggac ggagtccctt ggatcccatg accagcccag gatccgggct aattctccaa      600

gcaaattttg tccacagtca acgacgggag tccttcctgt atcgatccga cagcgattat      660

gacctctctc caaagtctat gtcccggaac tcctccattg ccagtgatat acacggagat      720

gacttgattg tgactccatt tgctcaggtc ttggccagtc tgcgaactgt acgaaacaac      780

tttgctgcat taactaattt gcaagatcga gcacctagca aaagatcacc catgtgcaac      840

caaccatcca tcaacaaagc caccataaca gaggaggcct accagaaact ggccagcgag      900

accctggagg agctggactg gtgtctggac cagctagaga ccctacagac caggcactcc      960

gtcagtgaga tggcctccaa caagtttaaa aggatgctta atcgggagct cacccatctc     1020

tctgaaatga gtcggtctgg aaatcaagtg tcagagttta tatcaaacac attcttagat     1080

aagcaacatg aagtggaaat tccttctcca actcagaagg aaaaggagaa aaagaaaaga     1140

ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca gctctagtct gactaattca     1200

agtatcccaa ggtttggagt taaaactgaa caagaagatg tccttgccaa ggaactagaa     1260

gatgtgaaca aatggggtct tcatgttttc agaatagcag agttgtctgg taaccggccc     1320

ttgactgtta tcatgcacac catttttcag gaacgggatt tattaaaaac atttaaaatt     1380

ccagtagata ctttaattac atatcttatg actctcgaag accattacca tgctgatgtg     1440

gcctatcaca acaatatcca tgctgcagat gttgtccagt ctactcatgt gctattatct     1500

acacctgctt tggaggctgt gtttacagat ttggagattc ttgcagcaat ttttgccagt     1560

gcaatacatg atgtagatca tcctggtgtg tccaatcaat ttctgatcaa tacaaactct     1620

gaacttgcct tgatgtacaa tgattcctca gtcttagaga accatcattt ggctgtgggc     1680

tttaaattgc ttcaggaaga aaactgtgac attttccaga atttgaccaa aaaacaaaga     1740

caatctttaa ggaaaatggt cattgacatc gtacttgcaa cagatatgtc aaaacacatg     1800

aatctactgg ctgatttgaa gactatggtt gaaactaaga aagtgacaag ctctggagtt     1860

cttcttcttg ataattattc cgataggatt caggttcttc agaatatggt gcactgtgca     1920

gatctgagca acccaacaaa gcctctccag ctgtaccgcc agtggacgga ccggataatg     1980

gaggagttct tccgccaagg agaccgagag agggaacgtg gcatggagat aagccccatg     2040

tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg gcttcataga ctatattgtt     2100

catcccctct gggagacatg ggcagacctc gtccaccctg acgcccagga tattttggac     2160

actttggagg acaatcgtga atggtaccag agcacaatcc ctcagagccc ctctcctgca     2220

cctgatgacc cagaggaggg ccggcagggt caaactgaga aattccagtt tgaactaact     2280

ttagaggaag atggtgagtc agacacggaa aaggacagtg gcagtcaagt ggaagaagac     2340

actagctgca gtgactccaa gactctttgt actcaagact cagagtctac tgaaattccc     2400

cttgatgaac aggttgaaga ggaggcagta ggggaagaag aggaaagcca gcctgaagcc     2460

tgtgtcatag atgatcgttc tcctgacacg taacagtgca aaaactttca tgcctttttt     2520

ttttttaagt agaaaaattg tttccaaagt gcatgtcaca tgccacaacc acggtcacac     2580

ctcactgtca tctgccagga cgtttgttga acaaaactga ccttgactac tcagtccagc     2640

gctcaggaat atcgtaacca gttttttcac ctccatgtca tccgagcaag gtggacatct     2700

tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc     2760

tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact     2820

tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga     2880

gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta     2940

ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga     3000

tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg     3060

taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta     3120

aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg     3180

caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt     3240

gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac     3300

caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt     3360

aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct     3420

tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatact tttatgtgtg     3480

ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca tcagttcgtg ttgtctgaag     3540

caagtgggag atatataaat acccagtagc taaaatggtc agtctttttt agatgttttc     3600

ctacttagta tctcctaata acgttttgct gtgtcactag atgttcattt cacaagtgca     3660

tgtctttcta ataatccaca catttcatgc tctaataatc cacacatttc atgctcattt     3720

ttattgtttt tacagccagt tatagtaaga aaaaggtttt tccccttgtg ctgctttata     3780

atttagcgtg tgtctgaacc ttatccatgt ttgctagatg aggtcttgtc aaatatatca     3840

ctaccattgt caccggtgaa aagaaacagg tagttaagtt agggttaaca ttcatttcaa     3900

ccacgaggtt gtatatcatg actagctttt actcttggtt tacagagaaa agttaaacag     3960

ccaactaggc agtttttaag aatattaaca atatattaac aaacaccaat acaactaatc     4020

ctatttggtt ttaatgattt caccatggga ttaagaacta tatcaggaac atccctgaga     4080

aacggtttta agtgtagcaa ctactcttcc ttaatggaca gccacataac gtgtaggaag     4140

tcctttatca cttatcctcg atccataagc atatcttgca gaggggaact acttctttaa     4200

acacatggag ggaaagaaga tgatgccact ggcaccagag ggttagtact gtgatgcatc     4260

ctaaaatatt tattatattg gtaaaaattc tggttaaata aaaaattaga gatcactctt     4320

ggctgatttc agcaccagga actgtattac agttttagag attaattcct agtgtttacc     4380

tgattatagc agttggcatc atggggcatt taattctgac tttatcccca cgtcagcctt     4440

aataaagtct tctttacctt ctctatgaag actttaaagc ccaaataatc atttttcaca     4500

ttgatattca agaattgaga tagatagaag ccaaagtggg tatctgacaa gtggaaaatc     4560

aaacgtttaa gaagaattac aactctgaaa agcatttata tgtggaactt ctcaaggagc     4620

ctcctgggga ctggaaagta agtcatcagc caggcaaatg actcatgctg aagagagtcc     4680

ccatttcagt cccctgagat ctagctgatg cttagatcct ttgaaataaa aattatgtct     4740

ttataactct gatcttttac ataaagcaga agaggaatca actagttaat tgcaaggttt     4800

ctactctgtt tcctctgtaa agatcagatg gtaatctttc aaataagaaa aaaataaaga     4860

cgtatgtttg accaagtagt ttcacaagaa tatttgggaa cttgtttctt ttaattttat     4920

ttgtccctga gtgaagtcta gaaagaaagg taaagagtct agagtttatt cctctttcca     4980

aaacattctc attcctctcc tccctacact tagtatttcc cccacagagt gcctagaatc     5040

ttaataatga ataaaataaa aagcagcaat atgtcattaa caaatccaga cctgaaaggg     5100

taaagggttt ataactgcac taataaagag aggctctttt tttttcttcc agtttgttgg     5160

tttttaatgg taccgtgttg taaagatacc cactaatgga caatcaaatt gcagaaaagg     5220

ctcaatatcc aagagacagg gactaatgca ctgtacaatc tgcttatcct tgcccttctc     5280

tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa aaagaataaa agaatatcct     5340

tttacaagtg gctttacatt tcctaaaatg ccataagaaa atgcaatatc tgggtactgt     5400

atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca tttcagcttg caagttactg     5460

aacacaataa tgctgtttta attttgtttt atatcagtta aaattcacaa taatgtagat     5520

agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa atggatttta cagaaagctt     5580

tatgataatt tttgaatgca ttatttattt tttgtgccat gcattttttt tctcaccaaa     5640

tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa ccatgtattt attgcaatgt     5700

acatactgta atgttaattg taaattatct gttcttatta aaacatcatc ccatgatggg     5760

atggtgttga tatatttgga aactcttggt gagagaatga atggtgtgta tacatactct     5820

gtacattttt cttttctcct gtaatatagt cttgtcacct tagagcttgt ttatggaaga     5880

ttcaagaaaa ctataaaata cttaaagata tataaattta aaaaaacata gctgcaggtc     5940

tttggtccca gggctgtgcc ttaactttaa ccaatatttt cttctgtttt gctgcatttg     6000

aaaggtaaca gtggagctag ggctgggcat tttacatcca ggcttttaat tgattagaat     6060

tctgccaata ggtggatttt acaaaaccac agacaacctc tgaaagattc tgagaccctt     6120

ttgagacaga agctcttaag tacttcttgc cagggagcag cactgcatgt gtgatggttg     6180

tttgccatct gttgatcagg aactacttca gctacttgca tttgattatt tccttttttt     6240

ttttttttaa ctcggaaaca caactgggga aatatattct ttcccagtga ttataaacaa     6300

tctttttctt ttttttaagt ccttttggct tctagagctc ataggaaaat ggacttgatt     6360

tgaaattgga gccagagttt actcgtgttg gttatctatt catcagcttc ctgacatgtt     6420

aagagaatac attaaagaga aaatactgtt ttttaatcct aaaatttttc ttccactaag     6480

ataaaccaaa tgtccttaca tatatgtaaa cccatctatt taaacgcaaa ggtgggttga     6540

tgtcagttta catagcagaa agcattcact atcctctaag atttgtttct gcaaaacttt     6600

cattgcttta gaattttaaa atttcacctt gtacaatggc cagcccctaa agcaggaaac     6660

atttataatg gattatatgg aaacatcctc ccagtacttg cccagccctt gaatcatgtg     6720

gcttttcagt gaaaggaaag attctttttc taggaaaaat gagcctattt tattttattt     6780

tattttattt tttgacacaa actgtagatt ttagcagccc tggcccaaag gaatttgatt     6840

acttttgttt taaacagtac aaaggggaca ctataattac aaaaacatcc ttaactgatt     6900

tgagttgttt ttatttcttt ggatatattt tcagagtggt aaattgtgtg tgagaattac     6960

aaatgattat tcttttagtg gtttcttagc ctctcttaca gcccacgggg atagtactgt     7020

acatcaatac cttcatatga aatttttata tgcaatgaaa ataaaagcat gggttgattc     7080

tgcctattta tgactcaatc ttttacaaat aaaagattat tcattttaaa ttatagttca     7140

atcagcatgt ctcttaggat actgaacgtg gttgaaatga aaggatagtg acatcataag     7200

ttagtactga tattcataac caaataaagc caacttgagt aattttgcta cattaaaaat     7260

taccaaaatt acttagatgg cctataagat taagcatggt gttttctaag caagctttga     7320

aaggggcctt ccatacttac ttaattgaat attctgggat attgaaaatt attcagatac     7380

ttgacaatta tttttggtta cctactccgc aaactacaaa gttttaagga ctcaacaata     7440

agttaatgag acacagtgtt tgctttcatg gagcttacag tctggagggg acaaaggctt     7500

aaacaatact catataatta tatatgtgat cagtacaatg aaggagctca gtggggtaaa     7560

taagcaggaa cctgaacttg atctgttccg gagggccaca gaaggcttcc ttgaggcctt     7620

gagaaagtga tttgcatctg agttctgaag gattgtaaga ggtaactagg gaaaaagttg     7680

acaggaagag gaaggggatc cagacaagaa acatttgcaa agatcttgag gcataaatga     7740

gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt aggcagggcc tggagccgca     7800

gagccattgc taaccatcct gtgtgagata tcccccattc tgtagcttta ttctcataac     7860

cctgctcaat tttctttata acacttctca cagatttata tacgtgtttg tttttgttat     7920

ctgtctctcc caccagacca cagctccatg agagcaaggt ctttgcttac caatatatca     7980

ctagcactta aaactatgcc tggtacacag taggttctta atatgtgttg aatatagcca     8040

tcaaattgat attggatata attcaatctg ataagatatt ttgagatatt aaagagtttt     8100

taacttgata ccataaaaaa aaaaaaaaaa                                      8130


<210>  28
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Phe Val Trp Asp Pro Leu Gly Ala Thr Val Pro Gly Pro Ser 
1               5                   10                  15      


Thr Arg Ala Lys Ser Arg Leu Arg Phe Ser Lys Ser Tyr Ser Phe Asp 
            20                  25                  30          


Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr 
        35                  40                  45              


Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln 
    50                  55                  60                  


Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser 
65                  70                  75                  80  


Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly 
                85                  90                  95      


Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg 
            100                 105                 110         


Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala 
        115                 120                 125             


Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala 
    130                 135                 140                 


Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu 
145                 150                 155                 160 


Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His 
                165                 170                 175     


Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg 
            180                 185                 190         


Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser 
        195                 200                 205             


Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile 
    210                 215                 220                 


Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser 
225                 230                 235                 240 


Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn 
                245                 250                 255     


Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu 
            260                 265                 270         


Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg 
        275                 280                 285             


Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr 
    290                 295                 300                 


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp 
305                 310                 315                 320 


Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp 
                325                 330                 335     


Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr 
            340                 345                 350         


His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
        355                 360                 365             


Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His 
    370                 375                 380                 


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
385                 390                 395                 400 


Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val 
                405                 410                 415     


Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu 
            420                 425                 430         


Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val 
        435                 440                 445             


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
    450                 455                 460                 


Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu 
465                 470                 475                 480 


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys 
                485                 490                 495     


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp 
            500                 505                 510         


Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg 
        515                 520                 525             


Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser 
    530                 535                 540                 


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu 
545                 550                 555                 560 


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu 
                565                 570                 575     


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln 
            580                 585                 590         


Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln 
        595                 600                 605             


Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser 
    610                 615                 620                 


Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys 
625                 630                 635                 640 


Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile 
                645                 650                 655     


Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu 
            660                 665                 670         


Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
        675                 680                 685         


<210>  29
<211>  8395
<212>  DNA
<213>  Homo sapiens

<400>  29
ttctcactgc cctgcggtgt tttgaactgc cttcttacag acgtcataca gcccttgagg       60

aatagtttct gcctggtgag attgaatgat agttctcatt cacaaaaccc tggattctaa      120

gcagggacac acagaaatta ctttcgcagg taaatcagcc cacccagcca aagtgtggag      180

agatttgttc cttggctgac ttctttgctc cacggagagg agtgttttcc tgtgcttgcc      240

ctgaaatgga acttccttga cagctctccc gtgttacagt acctcccggt cattttcttt      300

ttctctctct ctacctgcgc tcttcgagtg tcagaaacct ttaaagctgt tactatggaa      360

ttgcaaaaaa gagatcaagt gactctttca ctatgctggt ttcccttgtg acccagatga      420

agaatcaatt cagaattcag ttcctccctt ggcattgcaa gacacagaag aaactgtcac      480

ttcctaacag cctagtactg gagtaaattc agtatgaagg aagaaagcgc tcctgcgtgt      540

tagaaccttg cccatgagct ggaccgagga caggagatgg actccaggaa aattggattt      600

cttcaagcag cctcccttgg aaatggaata tctttaaaat cttctttgca gaaagacagt      660

tagaatgtat taatcagaat agttgaagac ttattttcct ttttattttt tttcaaaatg      720

agcattatta tgaagccaag atcccgatct acaagttccc taaggactgc agaggcagtt      780

tgttttgatg tggacaatgg cacatctgcg ggacggagtc ccttggatcc catgaccagc      840

ccaggatccg ggctaattct ccaagcaaat tttgtccaca gtcaacgacg ggagtccttc      900

ctgtatcgat ccgacagcga ttatgacctc tctccaaagt ctatgtcccg gaactcctcc      960

attgccagtg atatacacgg agatgacttg attgtgactc catttgctca ggtcttggcc     1020

agtctgcgaa ctgtacgaaa caactttgct gcattaacta atttgcaaga tcgagcacct     1080

agcaaaagat cacccatgtg caaccaacca tccatcaaca aagccaccat aacagaggag     1140

gcctaccaga aactggccag cgagaccctg gaggagctgg actggtgtct ggaccagcta     1200

gagaccctac agaccaggca ctccgtcagt gagatggcct ccaacaagtt taaaaggatg     1260

cttaatcggg agctcaccca tctctctgaa atgagtcggt ctggaaatca agtgtcagag     1320

tttatatcaa acacattctt agataagcaa catgaagtgg aaattccttc tccaactcag     1380

aaggaaaagg agaaaaagaa aagaccaatg tctcagatca gtggagtcaa gaaattgatg     1440

cacagctcta gtctgactaa ttcaagtatc ccaaggtttg gagttaaaac tgaacaagaa     1500

gatgtccttg ccaaggaact agaagatgtg aacaaatggg gtcttcatgt tttcagaata     1560

gcagagttgt ctggtaaccg gcccttgact gttatcatgc acaccatttt tcaggaacgg     1620

gatttattaa aaacatttaa aattccagta gatactttaa ttacatatct tatgactctc     1680

gaagaccatt accatgctga tgtggcctat cacaacaata tccatgctgc agatgttgtc     1740

cagtctactc atgtgctatt atctacacct gctttggagg ctgtgtttac agatttggag     1800

attcttgcag caatttttgc cagtgcaata catgatgtag atcatcctgg tgtgtccaat     1860

caatttctga tcaatacaaa ctctgaactt gccttgatgt acaatgattc ctcagtctta     1920

gagaaccatc atttggctgt gggctttaaa ttgcttcagg aagaaaactg tgacattttc     1980

cagaatttga ccaaaaaaca aagacaatct ttaaggaaaa tggtcattga catcgtactt     2040

gcaacagata tgtcaaaaca catgaatcta ctggctgatt tgaagactat ggttgaaact     2100

aagaaagtga caagctctgg agttcttctt cttgataatt attccgatag gattcaggtt     2160

cttcagaata tggtgcactg tgcagatctg agcaacccaa caaagcctct ccagctgtac     2220

cgccagtgga cggaccggat aatggaggag ttcttccgcc aaggagaccg agagagggaa     2280

cgtggcatgg agataagccc catgtgtgac aagcacaatg cttccgtgga aaaatcacag     2340

gtgggcttca tagactatat tgttcatccc ctctgggaga catgggcaga cctcgtccac     2400

cctgacgccc aggatatttt ggacactttg gaggacaatc gtgaatggta ccagagcaca     2460

atccctcaga gcccctctcc tgcacctgat gacccagagg agggccggca gggtcaaact     2520

gagaaattcc agtttgaact aactttagag gaagatggtg agtcagacac ggaaaaggac     2580

agtggcagtc aagtggaaga agacactagc tgcagtgact ccaagactct ttgtactcaa     2640

gactcagagt ctactgaaat tccccttgat gaacaggttg aagaggaggc agtaggggaa     2700

gaagaggaaa gccagcctga agcctgtgtc atagatgatc gttctcctga cacgtaacag     2760

tgcaaaaact ttcatgcctt tttttttttt aagtagaaaa attgtttcca aagtgcatgt     2820

cacatgccac aaccacggtc acacctcact gtcatctgcc aggacgtttg ttgaacaaaa     2880

ctgaccttga ctactcagtc cagcgctcag gaatatcgta accagttttt tcacctccat     2940

gtcatccgag caaggtggac atcttcacga acagcgtttt taacaagatt tcagcttggt     3000

agagctgaca aagcagataa aatctactcc aaattatttt caagagagtg tgactcatca     3060

ggcagcccaa aagtttattg gacttggggt ttctattcct ttttatttgt ttgcaatatt     3120

ttcagaagaa aggcattgca cagagtgaac ttaatggacg aagcaacaaa tatgtcaaga     3180

acaggacata gcacgaatct gttaccagta ggaggaggat gagccacaga aattgcataa     3240

ttttctaatt tcaagtcttc ctgatacatg actgaatagt gtggttcagt gagctgcact     3300

gacctctaca ttttgtatga tatgtaaaac agattttttg tagagcttac ttttattatt     3360

aaatgtattg aggtattata tttaaaaaaa actatgttca gaacttcatc tgccactggt     3420

tatttttttc taaggagtaa cttgcaagtt ttcagtacaa atctgtgcta cactggataa     3480

aaatctaatt tatgaatttt acttgcacct tatagttcat agcaattaac tgatttgtag     3540

tgattcattg tttgttttat ataccaatga cttccatatt ttaaaagaga aaaacaactt     3600

tatgttgcag gaaacccttt ttgtaagtct ttattattta ctttgcattt tgtttcactc     3660

tttccagata agcagagttg ctcttcacca gtgtttttct tcatgtgcaa agtgactatt     3720

tgttctataa tacttttatg tgtgttatat caaatgtgtc ttaagcttca tgcaaactca     3780

gtcatcagtt cgtgttgtct gaagcaagtg ggagatatat aaatacccag tagctaaaat     3840

ggtcagtctt ttttagatgt tttcctactt agtatctcct aataacgttt tgctgtgtca     3900

ctagatgttc atttcacaag tgcatgtctt tctaataatc cacacatttc atgctctaat     3960

aatccacaca tttcatgctc atttttattg tttttacagc cagttatagt aagaaaaagg     4020

tttttcccct tgtgctgctt tataatttag cgtgtgtctg aaccttatcc atgtttgcta     4080

gatgaggtct tgtcaaatat atcactacca ttgtcaccgg tgaaaagaaa caggtagtta     4140

agttagggtt aacattcatt tcaaccacga ggttgtatat catgactagc ttttactctt     4200

ggtttacaga gaaaagttaa acagccaact aggcagtttt taagaatatt aacaatatat     4260

taacaaacac caatacaact aatcctattt ggttttaatg atttcaccat gggattaaga     4320

actatatcag gaacatccct gagaaacggt tttaagtgta gcaactactc ttccttaatg     4380

gacagccaca taacgtgtag gaagtccttt atcacttatc ctcgatccat aagcatatct     4440

tgcagagggg aactacttct ttaaacacat ggagggaaag aagatgatgc cactggcacc     4500

agagggttag tactgtgatg catcctaaaa tatttattat attggtaaaa attctggtta     4560

aataaaaaat tagagatcac tcttggctga tttcagcacc aggaactgta ttacagtttt     4620

agagattaat tcctagtgtt tacctgatta tagcagttgg catcatgggg catttaattc     4680

tgactttatc cccacgtcag ccttaataaa gtcttcttta ccttctctat gaagacttta     4740

aagcccaaat aatcattttt cacattgata ttcaagaatt gagatagata gaagccaaag     4800

tgggtatctg acaagtggaa aatcaaacgt ttaagaagaa ttacaactct gaaaagcatt     4860

tatatgtgga acttctcaag gagcctcctg gggactggaa agtaagtcat cagccaggca     4920

aatgactcat gctgaagaga gtccccattt cagtcccctg agatctagct gatgcttaga     4980

tcctttgaaa taaaaattat gtctttataa ctctgatctt ttacataaag cagaagagga     5040

atcaactagt taattgcaag gtttctactc tgtttcctct gtaaagatca gatggtaatc     5100

tttcaaataa gaaaaaaata aagacgtatg tttgaccaag tagtttcaca agaatatttg     5160

ggaacttgtt tcttttaatt ttatttgtcc ctgagtgaag tctagaaaga aaggtaaaga     5220

gtctagagtt tattcctctt tccaaaacat tctcattcct ctcctcccta cacttagtat     5280

ttcccccaca gagtgcctag aatcttaata atgaataaaa taaaaagcag caatatgtca     5340

ttaacaaatc cagacctgaa agggtaaagg gtttataact gcactaataa agagaggctc     5400

tttttttttc ttccagtttg ttggttttta atggtaccgt gttgtaaaga tacccactaa     5460

tggacaatca aattgcagaa aaggctcaat atccaagaga cagggactaa tgcactgtac     5520

aatctgctta tccttgccct tctctcttgc caaagtgtgc ttcagaaata tatactgctt     5580

taaaaaagaa taaaagaata tccttttaca agtggcttta catttcctaa aatgccataa     5640

gaaaatgcaa tatctgggta ctgtatgggg aaaaaaatgt ccaagtttgt gtaaaaccag     5700

tgcatttcag cttgcaagtt actgaacaca ataatgctgt tttaattttg ttttatatca     5760

gttaaaattc acaataatgt agatagaaca aattacagac aaggaaagaa aaaacttgaa     5820

tgaaatggat tttacagaaa gctttatgat aatttttgaa tgcattattt attttttgtg     5880

ccatgcattt tttttctcac caaatgacct tacctgtaat acagtcttgt ttgtctgttt     5940

acaaccatgt atttattgca atgtacatac tgtaatgtta attgtaaatt atctgttctt     6000

attaaaacat catcccatga tgggatggtg ttgatatatt tggaaactct tggtgagaga     6060

atgaatggtg tgtatacata ctctgtacat ttttcttttc tcctgtaata tagtcttgtc     6120

accttagagc ttgtttatgg aagattcaag aaaactataa aatacttaaa gatatataaa     6180

tttaaaaaaa catagctgca ggtctttggt cccagggctg tgccttaact ttaaccaata     6240

ttttcttctg ttttgctgca tttgaaaggt aacagtggag ctagggctgg gcattttaca     6300

tccaggcttt taattgatta gaattctgcc aataggtgga ttttacaaaa ccacagacaa     6360

cctctgaaag attctgagac ccttttgaga cagaagctct taagtacttc ttgccaggga     6420

gcagcactgc atgtgtgatg gttgtttgcc atctgttgat caggaactac ttcagctact     6480

tgcatttgat tatttccttt tttttttttt ttaactcgga aacacaactg gggaaatata     6540

ttctttccca gtgattataa acaatctttt tctttttttt aagtcctttt ggcttctaga     6600

gctcatagga aaatggactt gatttgaaat tggagccaga gtttactcgt gttggttatc     6660

tattcatcag cttcctgaca tgttaagaga atacattaaa gagaaaatac tgttttttaa     6720

tcctaaaatt tttcttccac taagataaac caaatgtcct tacatatatg taaacccatc     6780

tatttaaacg caaaggtggg ttgatgtcag tttacatagc agaaagcatt cactatcctc     6840

taagatttgt ttctgcaaaa ctttcattgc tttagaattt taaaatttca ccttgtacaa     6900

tggccagccc ctaaagcagg aaacatttat aatggattat atggaaacat cctcccagta     6960

cttgcccagc ccttgaatca tgtggctttt cagtgaaagg aaagattctt tttctaggaa     7020

aaatgagcct attttatttt attttatttt attttttgac acaaactgta gattttagca     7080

gccctggccc aaaggaattt gattactttt gttttaaaca gtacaaaggg gacactataa     7140

ttacaaaaac atccttaact gatttgagtt gtttttattt ctttggatat attttcagag     7200

tggtaaattg tgtgtgagaa ttacaaatga ttattctttt agtggtttct tagcctctct     7260

tacagcccac ggggatagta ctgtacatca ataccttcat atgaaatttt tatatgcaat     7320

gaaaataaaa gcatgggttg attctgccta tttatgactc aatcttttac aaataaaaga     7380

ttattcattt taaattatag ttcaatcagc atgtctctta ggatactgaa cgtggttgaa     7440

atgaaaggat agtgacatca taagttagta ctgatattca taaccaaata aagccaactt     7500

gagtaatttt gctacattaa aaattaccaa aattacttag atggcctata agattaagca     7560

tggtgttttc taagcaagct ttgaaagggg ccttccatac ttacttaatt gaatattctg     7620

ggatattgaa aattattcag atacttgaca attatttttg gttacctact ccgcaaacta     7680

caaagtttta aggactcaac aataagttaa tgagacacag tgtttgcttt catggagctt     7740

acagtctgga ggggacaaag gcttaaacaa tactcatata attatatatg tgatcagtac     7800

aatgaaggag ctcagtgggg taaataagca ggaacctgaa cttgatctgt tccggagggc     7860

cacagaaggc ttccttgagg ccttgagaaa gtgatttgca tctgagttct gaaggattgt     7920

aagaggtaac tagggaaaaa gttgacagga agaggaaggg gatccagaca agaaacattt     7980

gcaaagatct tgaggcataa atgagcttga gacatctgga gaaactgagg aaaagtgaga     8040

gagtaggcag ggcctggagc cgcagagcca ttgctaacca tcctgtgtga gatatccccc     8100

attctgtagc tttattctca taaccctgct caattttctt tataacactt ctcacagatt     8160

tatatacgtg tttgtttttg ttatctgtct ctcccaccag accacagctc catgagagca     8220

aggtctttgc ttaccaatat atcactagca cttaaaacta tgcctggtac acagtaggtt     8280

cttaatatgt gttgaatata gccatcaaat tgatattgga tataattcaa tctgataaga     8340

tattttgaga tattaaagag tttttaactt gataccataa aaaaaaaaaa aaaaa          8395


<210>  30
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Ile Ile Met Lys Pro Arg Ser Arg Ser Thr Ser Ser Leu Arg 
1               5                   10                  15      


Thr Ala Glu Ala Val Cys Phe Asp Val Asp Asn Gly Thr Ser Ala Gly 
            20                  25                  30          


Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu Ile Leu 
        35                  40                  45              


Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg 
    50                  55                  60                  


Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg Asn Ser 
65                  70                  75                  80  


Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr Pro Phe 
                85                  90                  95      


Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe Ala Ala 
            100                 105                 110         


Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro Met Cys 
        115                 120                 125             


Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln 
    130                 135                 140                 


Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln 
145                 150                 155                 160 


Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala Ser Asn 
                165                 170                 175     


Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met 
            180                 185                 190         


Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu 
        195                 200                 205             


Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys 
    210                 215                 220                 


Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu 
225                 230                 235                 240 


Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val 
                245                 250                 255     


Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn 
            260                 265                 270         


Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg 
        275                 280                 285             


Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu 
    290                 295                 300                 


Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr 
305                 310                 315                 320 


Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His 
                325                 330                 335     


Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala 
            340                 345                 350         


Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala 
        355                 360                 365             


Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu 
    370                 375                 380                 


Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val 
385                 390                 395                 400 


Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu 
                405                 410                 415     


Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu 
            420                 425                 430         


Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His 
        435                 440                 445             


Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val 
    450                 455                 460                 


Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln 
465                 470                 475                 480 


Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys 
                485                 490                 495     


Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe 
            500                 505                 510         


Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro 
        515                 520                 525             


Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe 
    530                 535                 540                 


Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val 
545                 550                 555                 560 


His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu 
                565                 570                 575     


Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp 
            580                 585                 590         


Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu 
        595                 600                 605             


Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser 
    610                 615                 620                 


Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr 
625                 630                 635                 640 


Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu 
                645                 650                 655     


Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile 
            660                 665                 670         


Asp Asp Arg Ser Pro Asp Thr 
        675                 


<210>  31
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D9_forward primer

<400>  31
atgagcatta ttatgaagcc aagatc                                            26


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D9_reverse primer

<400>  32
gtgccattgt ccacatcaaa ac                                                22


<210>  33
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D9 probe

<400>  33
ctacaagttc cctaaggact gcagagg                                           27


<210>  34
<211>  1435
<212>  DNA
<213>  Homo sapiens

<400>  34
ggcggggcct gcttctcctc agcttcaggc ggctgcgacg agccctcagg cgaacctctc       60

ggctttcccg cgcggcgccg cctcttgctg cgcctccgcc tcctcctctg ctccgccacc      120

ggcttcctcc tcctgagcag tcagcccgcg cgccggccgg ctccgttatg gcgacccgca      180

gccctggcgt cgtgattagt gatgatgaac caggttatga ccttgattta ttttgcatac      240

ctaatcatta tgctgaggat ttggaaaggg tgtttattcc tcatggacta attatggaca      300

ggactgaacg tcttgctcga gatgtgatga aggagatggg aggccatcac attgtagccc      360

tctgtgtgct caaggggggc tataaattct ttgctgacct gctggattac atcaaagcac      420

tgaatagaaa tagtgataga tccattccta tgactgtaga ttttatcaga ctgaagagct      480

attgtaatga ccagtcaaca ggggacataa aagtaattgg tggagatgat ctctcaactt      540

taactggaaa gaatgtcttg attgtggaag atataattga cactggcaaa acaatgcaga      600

ctttgctttc cttggtcagg cagtataatc caaagatggt caaggtcgca agcttgctgg      660

tgaaaaggac cccacgaagt gttggatata agccagactt tgttggattt gaaattccag      720

acaagtttgt tgtaggatat gcccttgact ataatgaata cttcagggat ttgaatcatg      780

tttgtgtcat tagtgaaact ggaaaagcaa aatacaaagc ctaagatgag agttcaagtt      840

gagtttggaa acatctggag tcctattgac atcgccagta aaattatcaa tgttctagtt      900

ctgtggccat ctgcttagta gagctttttg catgtatctt ctaagaattt tatctgtttt      960

gtactttaga aatgtcagtt gctgcattcc taaactgttt atttgcacta tgagcctata     1020

gactatcagt tccctttggg cggattgttg tttaacttgt aaatgaaaaa attctcttaa     1080

accacagcac tattgagtga aacattgaac tcatatctgt aagaaataaa gagaagatat     1140

attagttttt taattggtat tttaattttt atatatgcag gaaagaatag aagtgattga     1200

atattgttaa ttataccacc gtgtgttaga aaagtaagaa gcagtcaatt ttcacatcaa     1260

agacagcatc taagaagttt tgttctgtcc tggaattatt ttagtagtgt ttcagtaatg     1320

ttgactgtat tttccaactt gttcaaatta ttaccagtga atctttgtca gcagttccct     1380

tttaaatgca aatcaataaa ttcccaaaaa tttaaaaaaa aaaaaaaaaa aaaaa          1435


<210>  35
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly 
1               5                   10                  15      


Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu 
            20                  25                  30          


Glu Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg 
        35                  40                  45              


Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala 
    50                  55                  60                  


Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp 
65                  70                  75                  80  


Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr 
                85                  90                  95      


Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly 
            100                 105                 110         


Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys 
        115                 120                 125             


Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln 
    130                 135                 140                 


Thr Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val 
145                 150                 155                 160 


Ala Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro 
                165                 170                 175     


Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala 
            180                 185                 190         


Leu Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile 
        195                 200                 205             


Ser Glu Thr Gly Lys Ala Lys Tyr Lys Ala 
    210                 215             


<210>  36
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT1_forward primer

<400>  36
gaggatttgg aaagggtgtt tatt                                              24


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT1_reverse primer

<400>  37
acagagggct acaatgtgat g                                                 21


<210>  38
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT1 probe

<400>  38
acgtcttgct cgagatgtga tgaagg                                            26


<210>  39
<211>  1771
<212>  DNA
<213>  Homo sapiens

<400>  39
ggcggccagg ccgggcgcgg agtgggcgcg cggggccgga ggaggggcca gcgaccgcgg       60

caccgcctgt gcccgcccgc ccctccgcag ccgctactta agaggctcca gcgccggccc      120

cgccctagtg cgttacttac ctcgactctt agcttgtcgg ggacggtaac cgggacccgg      180

tgtctgctcc tgtcgccttc gcctcctaat ccctagccac tatgcgtgag tgcatctcca      240

tccacgttgg ccaggctggt gtccagattg gcaatgcctg ctgggagctc tactgcctgg      300

aacacggcat ccagcccgat ggccagatgc caagtgacaa gaccattggg ggaggagatg      360

actccttcaa caccttcttc agtgagacgg gcgctggcaa gcacgtgccc cgggctgtgt      420

ttgtagactt ggaacccaca gtcattgatg aagttcgcac tggcacctac cgccagctct      480

tccaccctga gcagctcatc acaggcaagg aagatgctgc caataactat gcccgagggc      540

actacaccat tggcaaggag atcattgacc ttgtgttgga ccgaattcgc aagctggctg      600

accagtgcac cggtcttcag ggcttcttgg ttttccacag ctttggtggg ggaactggtt      660

ctgggttcac ctccctgctc atggaacgtc tctcagttga ttatggcaag aagtccaagc      720

tggagttctc catttaccca gcaccccagg tttccacagc tgtagttgag ccctacaact      780

ccatcctcac cacccacacc accctggagc actctgattg tgccttcatg gtagacaatg      840

aggccatcta tgacatctgt cgtagaaacc tcgatatcga gcgcccaacc tacactaacc      900

ttaaccgcct tattagccag attgtgtcct ccatcactgc ttccctgaga tttgatggag      960

ccctgaatgt tgacctgaca gaattccaga ccaacctggt gccctacccc cgcatccact     1020

tccctctggc cacatatgcc cctgtcatct ctgctgagaa agcctaccat gaacagcttt     1080

ctgtagcaga gatcaccaat gcttgctttg agccagccaa ccagatggtg aaatgtgacc     1140

ctcgccatgg taaatacatg gcttgctgcc tgttgtaccg tggtgacgtg gttcccaaag     1200

atgtcaatgc tgccattgcc accatcaaaa ccaagcgcag catccagttt gtggattggt     1260

gccccactgg cttcaaggtt ggcatcaact accagcctcc cactgtggtg cctggtggag     1320

acctggccaa ggtacagaga gctgtgtgca tgctgagcaa caccacagcc attgctgagg     1380

cctgggctcg cctggaccac aagtttgacc tgatgtatgc caagcgtgcc tttgttcact     1440

ggtacgtggg tgaggggatg gaggaaggcg agttttcaga ggcccgtgaa gatatggctg     1500

cccttgagaa ggattatgag gaggttggtg tggattctgt tgaaggagag ggtgaggaag     1560

aaggagagga atactaatta tccattcctt ttggccctgc agcatgtcat gctcccagaa     1620

tttcagcttc agcttaactg acagacgtta aagctttctg gttagattgt tttcacttgg     1680

tgatcatgtc ttttccatgt gtacctgtaa tatttttcca tcatatctca aagtaaagtc     1740

attaacatca aaaaaaaaaa aaaaaaaaaa a                                    1771


<210>  40
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TUBA1B_forward primer

<400>  41
tgactccttc aacaccttct tc                                                22


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TUBA1B_reverse primer

<400>  42
tgccagtgcg aacttcat                                                     18


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TUBA1B probe

<400>  43
ccgggctgtg tttgtagact tgga                                              24


<210>  44
<211>  5416
<212>  DNA
<213>  Homo sapiens

<400>  44
agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc agagagagaa       60

gatcgggggg ctgaaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg      120

ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga      180

aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag      240

ggtcgcaagc gcagccacaa ccagctgcaa atcaggctct tgcagctggg actcactcca      300

gccctgtccc aggatctata ggagttgcag gccgttccca ggacgacgct atggtggact      360

acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtgga ggaggcggct      420

ataataatag caaacatcga tggcctactg gggataacat tcatgcagaa catcaggtgc      480

gttccatgga tgaactgaat catgattttc aagcacttgc tctggaggga agagcgatgg      540

gagagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac      600

caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt      660

cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg      720

aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg      780

agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa      840

gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt acgtttgatg      900

gagataagct aggagatttg aaggaggagg gtgatgtgat ggacaagacc aatggtttac      960

cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc     1020

agaactctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag     1080

cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc     1140

agagtgtccc cttggacccc atggaacatg tgggcatgga gcctcttcag tttgattatt     1200

caggcacgca ggtacctgtg gactcagcag cagcaactgt gggacttttt gactacaatt     1260

ctcaacaaca gctgttccaa agacctaatg cgcttgctgt ccagcagttg acagctgctc     1320

agcagcagca gtatgcactg gcagctgctc atcagccgca catcggttta gctcccgctg     1380

cgtttgtccc caatccatac atcatcagcg ctgctccccc agggacggac ccctacacag     1440

ctggattggc tgcagcagcg acactaggcc cagctgtggt ccctcaccag tattatggag     1500

ttactccctg gggagtctac cctgccagtc ttttccagca gcaagctgcc gctgccgctg     1560

cagcaactaa ttcagctaat caacagacca ccccacaggc tcagcaagga cagcagcagg     1620

ttctccgtgg aggagccagc caacgtcctt tgaccccaaa ccagaaccag cagggacagc     1680

aaacggatcc ccttgtggca gctgcagcag tgaattctgc ccttgcattt ggacaaggtc     1740

tggcagcagg catgccaggt tatccggtgt tggctcctgc tgcttactat gaccaaactg     1800

gtgcccttgt agtgaatgca ggcgcgagaa atggtcttgg agctcctgtt cgacttgtag     1860

ctcctgcccc agtcatcatt agttcctcag ctgcacaagc agctgttgca gcagccgcag     1920

cttcagcaaa tggagcagct ggtggtcttg ctggaacaac aaatggacca tttcgccctt     1980

taggaacaca gcagcctcag ccccagcccc agcagcagcc caataacaac ctggcatcca     2040

gttctttcta cggcaacaac tctctgaaca gcaattcaca gagcagctcc ctcttctccc     2100

agggctctgc ccagcctgcc aacacatcct tgggattcgg aagtagcagt tctctcggcg     2160

ccaccctggg atccgccctt ggagggtttg gaacagcagt tgcaaactcc aacactggca     2220

gtggctcccg ccgtgactcc ctgactggca gcagtgacct ttataagagg acatcgagca     2280

gcttgacccc cattggacac agtttttata acggccttag cttttcctcc tctcctggac     2340

ccgtgggcat gcctctccct agtcagggac caggacattc acagacacca cctccttccc     2400

tctcttcaca tggatcctct tcaagcttaa acctgggagg actcacgaat ggcagtggaa     2460

gatacatctc tgctgctcca ggcgctgaag ccaagtaccg cagtgcaagc agcgcctcca     2520

gcctcttcag cccgagcagc actcttttct cttcctctcg tttgcgatat ggaatgtctg     2580

atgtcatgcc ttctggcagg agcaggcttt tggaagattt tcgaaacaac cggtacccca     2640

atttacaact gcgggagatt gctggacata taatggaatt ttcccaagac cagcatgggt     2700

ccagattcat tcagctgaaa ctggagcgtg ccacaccagc tgagcgccag cttgtcttca     2760

atgaaatcct ccaggctgcc taccaactca tggtggatgt gtttggtaat tacgtcattc     2820

agaagttctt tgaatttggc agtcttgaac agaagctggc tttggcagaa cggattcgag     2880

gccacgtcct gtcattggca ctacagatgt atggctgccg tgttatccag aaagctcttg     2940

agtttattcc ttcagaccag caggtaatta atgagatggt tcgggaacta gatggccatg     3000

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     3060

tacagcccca gtctttgcaa tttatcatcg atgcgtttaa gggacaggta tttgccttat     3120

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     3180

agacactccc tattttagag gagcttcacc agcacacaga gcagcttgta caggatcaat     3240

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     3300

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     3360

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgatgagg     3420

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     3480

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     3540

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     3600

tggccaagct ggagaagtac tacatgaaga acggtgttga cttagggccc atctgtggcc     3660

cccctaatgg tatcatctga ggcagtgtca cccgctgttc cctcattccc gctgacctca     3720

ctggcccact ggcaaatcca accagcaacc agaaatgttc tagtgtagag tctgagacgg     3780

gcaagtggtt gctccaggat tactccctcc tccaaaaaag gaatcaaatc cacgagtgga     3840

aaagcctttg taaatttaat tttattacac ataacatgta ctattttttt taattgacta     3900

attgccctgc tgttttactg gtgtatagga tacttgtaca taggtaacca atgtacatgg     3960

gaggccacat attttgttca ctgttgtatc tatatttcac atgtggaaac tttcagggtg     4020

gttggtttaa caaaaaaaaa aagctttaaa aaaaaaagaa aaaaaggaaa aggtttttag     4080

ctcatttgcc tggccggcaa gttttgcaaa tagctcttcc ccacctcctc attttagtaa     4140

aaaacaaaca aaaacaaaaa aacctgagaa gtttgaattg tagttaaatg accccaaact     4200

ggcatttaac actgtttata aaaaatatat atatatatat atatatatat aatgaaaaag     4260

gtttcagagt tgctaaagct tcagtttgtg acattaagtt tatgaaattc taaaaaatgc     4320

cttttttgga gactatatta tgctgaagaa ggctgttcgt gaggaggaga tgcgagcacc     4380

cagaacgtct tttgaggctg ggcgggtgtg attgtttact gcctactgga tttttttcta     4440

ttaacattga aaggtaaaat ctgattattt agcatgagaa aaaaaaatcc aactctgctt     4500

ttggtcttgc ttctataaat atatagtgta tacttggtgt agactttgca tatatacaaa     4560

tttgtagtat tttcttgttt tgatgtctaa tctgtatcta taatgtaccc tagtagtcga     4620

acatactttt gattgtacaa ttgtacattt gtatacctgt aatgtaaatg tggagaagtt     4680

tgaatcaaca taaacacgtt ttttggtaag aaaagagaat tagccagccc tgtgcattca     4740

gtgtatattc tcacctttta tggtcgtagc atatagtgtt gtatattgta aattgtaatt     4800

tcaaccagaa gtaaattttt ttcttttgaa ggaataaatg ttctttatac agcctagtta     4860

atgtttaaaa agaaaaaaat agcttggttt tatttgtcat ctagtctcaa gtatagcgag     4920

attctttcta aatgttattc aagattgagt tctcactagt gtttttttaa tcctaaaaaa     4980

gtaatgtttt gattttgtga cagtcaaaag gacgtgcaaa agtctagcct tgcccgagct     5040

ttccttacaa tcagagcccc tctcaccttg taaagtgtga atcgcccttc ccttttgtac     5100

agaagatgaa ctgtattttg cattttgtct acttgtaagt gaatgtaaca tactgtcaat     5160

tttccttgtt tgaatataga attgtaacac tacacggtgt acatttccag agccttgtgt     5220

atatttccaa tgaacttttt tgcaagcaca cttgtaacca tatgtgtata attaacaaac     5280

ctgtgtatgc ttatgcctgg gcaactattt tttgtaactc ttgtgtagat tgtctctaaa     5340

caatgtgtga tctttatttt gaaaaataca gaactttgga atctgaaaaa aaaaaaaaaa     5400

aaaaaaaaaa aaaaaa                                                     5416


<210>  45
<211>  5410
<212>  DNA
<213>  Homo sapiens

<400>  45
agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc agagagagaa       60

gatcgggggg ctgaaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg      120

ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga      180

aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag      240

ggtcgcaagc gcagccacaa ccagctgcaa atcaggctct tgcagctggg actcactcca      300

gccctgtccc aggatctata ggagttgcag gccgttccca ggacgacgct atggtggact      360

acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtgga ggaggcggct      420

ataataatag caaacatcga tggcctactg gggataacat tcatgcagaa catcaggtgc      480

gttccatgga tgaactgaat catgattttc aagcacttgc tctggaggga agagcgatgg      540

gagagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac      600

caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt      660

cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg      720

aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg      780

agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa      840

gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt acgtttgatg      900

gagataagct aggagatttg aaggaggagg gtgatgtgat ggacaagacc aatggtttac      960

cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc     1020

agaactctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag     1080

cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc     1140

agagtgtccc cttggacccc atggaacatg tgggcatgga gcctcttcag tttgattatt     1200

caggcacgca ggtacctgtg gactcagcag cagcaactgt gggacttttt gactacaatt     1260

ctcaacaaca gctgttccaa agacctaatg cgcttgctgt ccagcagttg acagctgctc     1320

agcagcagca gtatgcactg gcagctgctc atcagccgca catcggttta gctcccgctg     1380

cgtttgtccc caatccatac atcatcagcg ctgctccccc agggacggac ccctacacag     1440

ctggattggc tgcagcagcg acactaggcc cagctgtggt ccctcaccag tattatggag     1500

ttactccctg gggagtctac cctgccagtc ttttccagca gcaagctgcc gctgccgctg     1560

cagcaactaa ttcagctaat caacagacca ccccacaggc tcagcaagga cagcagcagg     1620

ttctccgtgg aggagccagc caacgtcctt tgaccccaaa ccagaaccag cagggacagc     1680

aaacggatcc ccttgtggca gctgcagcag tgaattctgc ccttgcattt ggacaaggtc     1740

tggcagcagg catgccaggt tatccggtgt tggctcctgc tgcttactat gaccaaactg     1800

gtgcccttgt agtgaatgca ggcgcgagaa atggtcttgg agctcctgtt cgacttgtag     1860

ctcctgcccc agtcatcatt agttcctcag ctgcacaagc agctgttgca gcagccgcag     1920

cttcagcaaa tggagcagct ggtggtcttg ctggaacaac aaatggacca tttcgccctt     1980

taggaacaca gcagcctcag ccccagcccc agcagcagcc caataacaac ctggcatcca     2040

gttctttcta cggcaacaac tctctgaaca gcaattcaca gagcagctcc ctcttctccc     2100

agggctctgc ccagcctgcc aacacatcct tgggattcgg aagtagcagt tctctcggcg     2160

ccaccctggg atccgccctt ggagggtttg gaacagcagt tgcaaactcc aacactggca     2220

gtggctcccg ccgtgactcc ctgactggca gcagtgacct ttataagagg acatcgagca     2280

gcttgacccc cattggacac agtttttata acggccttag cttttcctcc tctcctggac     2340

ccgtgggcat gcctctccct agtcagggac caggacattc acagacacca cctccttccc     2400

tctcttcaca tggatcctct tcaagcttaa acctgggagg actcacgaat ggcagtggaa     2460

gatacatctc tgctgctcca ggcgctgaag ccaagtaccg cagtgcaagc agcgcctcca     2520

gcctcttcag cccgagcagc actcttttct cttcctctcg tttgcgatat ggaatgtctg     2580

atgtcatgcc ttctggcagg agcaggcttt tggaagattt tcgaaacaac cggtacccca     2640

atttacaact gcgggagatt gctggacata taatggaatt ttcccaagac cagcatgggt     2700

ccagattcat tcagctgaaa ctggagcgtg ccacaccagc tgagcgccag cttgtcttca     2760

atgaaatcct ccaggctgcc taccaactca tggtggatgt gtttggtaat tacgtcattc     2820

agaagttctt tgaatttggc agtcttgaac agaagctggc tttggcagaa cggattcgag     2880

gccacgtcct gtcattggca ctacagatgt atggctgccg tgttatccag aaagctcttg     2940

agtttattcc ttcagaccag cagaatgaga tggttcggga actagatggc catgtcttga     3000

agtgtgtgaa agatcagaat ggcaatcacg tggttcagaa atgcattgaa tgtgtacagc     3060

cccagtcttt gcaatttatc atcgatgcgt ttaagggaca ggtatttgcc ttatccacac     3120

atccttatgg ctgccgagtg attcagagaa tcctggagca ctgtctccct gaccagacac     3180

tccctatttt agaggagctt caccagcaca cagagcagct tgtacaggat caatatggaa     3240

attatgtaat ccaacatgta ctggagcacg gtcgtcctga ggataaaagc aaaattgtag     3300

cagaaatccg aggcaatgta cttgtattga gtcagcacaa atttgcaagc aatgttgtgg     3360

agaagtgtgt tactcacgcc tcacgtacgg agcgcgctgt gctcatcgat gaggtgtgca     3420

ccatgaacga cggtccccac agtgccttat acaccatgat gaaggaccag tatgccaact     3480

acgtggtcca gaagatgatt gacgtggcgg agccaggcca gcggaagatc gtcatgcata     3540

agatccggcc ccacatcgca actcttcgta agtacaccta tggcaagcac attctggcca     3600

agctggagaa gtactacatg aagaacggtg ttgacttagg gcccatctgt ggccccccta     3660

atggtatcat ctgaggcagt gtcacccgct gttccctcat tcccgctgac ctcactggcc     3720

cactggcaaa tccaaccagc aaccagaaat gttctagtgt agagtctgag acgggcaagt     3780

ggttgctcca ggattactcc ctcctccaaa aaaggaatca aatccacgag tggaaaagcc     3840

tttgtaaatt taattttatt acacataaca tgtactattt tttttaattg actaattgcc     3900

ctgctgtttt actggtgtat aggatacttg tacataggta accaatgtac atgggaggcc     3960

acatattttg ttcactgttg tatctatatt tcacatgtgg aaactttcag ggtggttggt     4020

ttaacaaaaa aaaaaagctt taaaaaaaaa agaaaaaaag gaaaaggttt ttagctcatt     4080

tgcctggccg gcaagttttg caaatagctc ttccccacct cctcatttta gtaaaaaaca     4140

aacaaaaaca aaaaaacctg agaagtttga attgtagtta aatgacccca aactggcatt     4200

taacactgtt tataaaaaat atatatatat atatatatat atataatgaa aaaggtttca     4260

gagttgctaa agcttcagtt tgtgacatta agtttatgaa attctaaaaa atgccttttt     4320

tggagactat attatgctga agaaggctgt tcgtgaggag gagatgcgag cacccagaac     4380

gtcttttgag gctgggcggg tgtgattgtt tactgcctac tggatttttt tctattaaca     4440

ttgaaaggta aaatctgatt atttagcatg agaaaaaaaa atccaactct gcttttggtc     4500

ttgcttctat aaatatatag tgtatacttg gtgtagactt tgcatatata caaatttgta     4560

gtattttctt gttttgatgt ctaatctgta tctataatgt accctagtag tcgaacatac     4620

ttttgattgt acaattgtac atttgtatac ctgtaatgta aatgtggaga agtttgaatc     4680

aacataaaca cgttttttgg taagaaaaga gaattagcca gccctgtgca ttcagtgtat     4740

attctcacct tttatggtcg tagcatatag tgttgtatat tgtaaattgt aatttcaacc     4800

agaagtaaat ttttttcttt tgaaggaata aatgttcttt atacagccta gttaatgttt     4860

aaaaagaaaa aaatagcttg gttttatttg tcatctagtc tcaagtatag cgagattctt     4920

tctaaatgtt attcaagatt gagttctcac tagtgttttt ttaatcctaa aaaagtaatg     4980

ttttgatttt gtgacagtca aaaggacgtg caaaagtcta gccttgcccg agctttcctt     5040

acaatcagag cccctctcac cttgtaaagt gtgaatcgcc cttccctttt gtacagaaga     5100

tgaactgtat tttgcatttt gtctacttgt aagtgaatgt aacatactgt caattttcct     5160

tgtttgaata tagaattgta acactacacg gtgtacattt ccagagcctt gtgtatattt     5220

ccaatgaact tttttgcaag cacacttgta accatatgtg tataattaac aaacctgtgt     5280

atgcttatgc ctgggcaact attttttgta actcttgtgt agattgtctc taaacaatgt     5340

gtgatcttta ttttgaaaaa tacagaactt tggaatctga aaaaaaaaaa aaaaaaaaaa     5400

aaaaaaaaaa                                                            5410


<210>  46
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Val Ala Cys Val Leu Lys Arg Lys Ala Val Leu Trp Gln Asp 
1               5                   10                  15      


Ser Phe Ser Pro His Leu Lys His His Pro Gln Glu Pro Ala Asn Pro 
            20                  25                  30          


Asn Met Pro Val Val Leu Thr Ser Gly Thr Gly Ser Gln Ala Gln Pro 
        35                  40                  45              


Gln Pro Ala Ala Asn Gln Ala Leu Ala Ala Gly Thr His Ser Ser Pro 
    50                  55                  60                  


Val Pro Gly Ser Ile Gly Val Ala Gly Arg Ser Gln Asp Asp Ala Met 
65                  70                  75                  80  


Val Asp Tyr Phe Phe Gln Arg Gln His Gly Glu Gln Leu Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Tyr Asn Asn Ser Lys His Arg Trp Pro Thr 
            100                 105                 110         


Gly Asp Asn Ile His Ala Glu His Gln Val Arg Ser Met Asp Glu Leu 
        115                 120                 125             


Asn His Asp Phe Gln Ala Leu Ala Leu Glu Gly Arg Ala Met Gly Glu 
    130                 135                 140                 


Gln Leu Leu Pro Gly Lys Lys Phe Trp Glu Thr Asp Glu Ser Ser Lys 
145                 150                 155                 160 


Asp Gly Pro Lys Gly Ile Phe Leu Gly Asp Gln Trp Arg Asp Ser Ala 
                165                 170                 175     


Trp Gly Thr Ser Asp His Ser Val Ser Gln Pro Ile Met Val Gln Arg 
            180                 185                 190         


Arg Pro Gly Gln Ser Phe His Val Asn Ser Glu Val Asn Ser Val Leu 
        195                 200                 205             


Ser Pro Arg Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu Tyr 
    210                 215                 220                 


Val Leu Ser Ser Ser Pro Gly Asp Ser Cys Leu Arg Lys Gly Gly Phe 
225                 230                 235                 240 


Gly Pro Arg Asp Ala Asp Ser Asp Glu Asn Asp Lys Gly Glu Lys Lys 
                245                 250                 255     


Asn Lys Gly Thr Phe Asp Gly Asp Lys Leu Gly Asp Leu Lys Glu Glu 
            260                 265                 270         


Gly Asp Val Met Asp Lys Thr Asn Gly Leu Pro Val Gln Asn Gly Ile 
        275                 280                 285             


Asp Ala Asp Val Lys Asp Phe Ser Arg Thr Pro Gly Asn Cys Gln Asn 
    290                 295                 300                 


Ser Ala Asn Glu Val Asp Leu Leu Gly Pro Asn Gln Asn Gly Ser Glu 
305                 310                 315                 320 


Gly Leu Ala Gln Leu Thr Ser Thr Asn Gly Ala Lys Pro Val Glu Asp 
                325                 330                 335     


Phe Ser Asn Met Glu Ser Gln Ser Val Pro Leu Asp Pro Met Glu His 
            340                 345                 350         


Val Gly Met Glu Pro Leu Gln Phe Asp Tyr Ser Gly Thr Gln Val Pro 
        355                 360                 365             


Val Asp Ser Ala Ala Ala Thr Val Gly Leu Phe Asp Tyr Asn Ser Gln 
    370                 375                 380                 


Gln Gln Leu Phe Gln Arg Pro Asn Ala Leu Ala Val Gln Gln Leu Thr 
385                 390                 395                 400 


Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala Ala His Gln Pro His 
                405                 410                 415     


Ile Gly Leu Ala Pro Ala Ala Phe Val Pro Asn Pro Tyr Ile Ile Ser 
            420                 425                 430         


Ala Ala Pro Pro Gly Thr Asp Pro Tyr Thr Ala Gly Leu Ala Ala Ala 
        435                 440                 445             


Ala Thr Leu Gly Pro Ala Val Val Pro His Gln Tyr Tyr Gly Val Thr 
    450                 455                 460                 


Pro Trp Gly Val Tyr Pro Ala Ser Leu Phe Gln Gln Gln Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Thr Asn Ser Ala Asn Gln Gln Thr Thr Pro Gln Ala 
                485                 490                 495     


Gln Gln Gly Gln Gln Gln Val Leu Arg Gly Gly Ala Ser Gln Arg Pro 
            500                 505                 510         


Leu Thr Pro Asn Gln Asn Gln Gln Gly Gln Gln Thr Asp Pro Leu Val 
        515                 520                 525             


Ala Ala Ala Ala Val Asn Ser Ala Leu Ala Phe Gly Gln Gly Leu Ala 
    530                 535                 540                 


Ala Gly Met Pro Gly Tyr Pro Val Leu Ala Pro Ala Ala Tyr Tyr Asp 
545                 550                 555                 560 


Gln Thr Gly Ala Leu Val Val Asn Ala Gly Ala Arg Asn Gly Leu Gly 
                565                 570                 575     


Ala Pro Val Arg Leu Val Ala Pro Ala Pro Val Ile Ile Ser Ser Ser 
            580                 585                 590         


Ala Ala Gln Ala Ala Val Ala Ala Ala Ala Ala Ser Ala Asn Gly Ala 
        595                 600                 605             


Ala Gly Gly Leu Ala Gly Thr Thr Asn Gly Pro Phe Arg Pro Leu Gly 
    610                 615                 620                 


Thr Gln Gln Pro Gln Pro Gln Pro Gln Gln Gln Pro Asn Asn Asn Leu 
625                 630                 635                 640 


Ala Ser Ser Ser Phe Tyr Gly Asn Asn Ser Leu Asn Ser Asn Ser Gln 
                645                 650                 655     


Ser Ser Ser Leu Phe Ser Gln Gly Ser Ala Gln Pro Ala Asn Thr Ser 
            660                 665                 670         


Leu Gly Phe Gly Ser Ser Ser Ser Leu Gly Ala Thr Leu Gly Ser Ala 
        675                 680                 685             


Leu Gly Gly Phe Gly Thr Ala Val Ala Asn Ser Asn Thr Gly Ser Gly 
    690                 695                 700                 


Ser Arg Arg Asp Ser Leu Thr Gly Ser Ser Asp Leu Tyr Lys Arg Thr 
705                 710                 715                 720 


Ser Ser Ser Leu Thr Pro Ile Gly His Ser Phe Tyr Asn Gly Leu Ser 
                725                 730                 735     


Phe Ser Ser Ser Pro Gly Pro Val Gly Met Pro Leu Pro Ser Gln Gly 
            740                 745                 750         


Pro Gly His Ser Gln Thr Pro Pro Pro Ser Leu Ser Ser His Gly Ser 
        755                 760                 765             


Ser Ser Ser Leu Asn Leu Gly Gly Leu Thr Asn Gly Ser Gly Arg Tyr 
    770                 775                 780                 


Ile Ser Ala Ala Pro Gly Ala Glu Ala Lys Tyr Arg Ser Ala Ser Ser 
785                 790                 795                 800 


Ala Ser Ser Leu Phe Ser Pro Ser Ser Thr Leu Phe Ser Ser Ser Arg 
                805                 810                 815     


Leu Arg Tyr Gly Met Ser Asp Val Met Pro Ser Gly Arg Ser Arg Leu 
            820                 825                 830         


Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu 
        835                 840                 845             


Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg 
    850                 855                 860                 


Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
865                 870                 875                 880 


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
                885                 890                 895     


Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu 
            900                 905                 910         


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
        915                 920                 925             


Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe 
    930                 935                 940                 


Ile Pro Ser Asp Gln Gln Val Ile Asn Glu Met Val Arg Glu Leu Asp 
945                 950                 955                 960 


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
                965                 970                 975     


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
            980                 985                 990         


Asp Ala Phe Lys Gly Gln Val Phe  Ala Leu Ser Thr His  Pro Tyr Gly 
        995                 1000                 1005             


Cys Arg  Val Ile Gln Arg Ile  Leu Glu His Cys Leu  Pro Asp Gln 
    1010                 1015                 1020             


Thr Leu  Pro Ile Leu Glu Glu  Leu His Gln His Thr  Glu Gln Leu 
    1025                 1030                 1035             


Val Gln  Asp Gln Tyr Gly Asn  Tyr Val Ile Gln His  Val Leu Glu 
    1040                 1045                 1050             


His Gly  Arg Pro Glu Asp Lys  Ser Lys Ile Val Ala  Glu Ile Arg 
    1055                 1060                 1065             


Gly Asn  Val Leu Val Leu Ser  Gln His Lys Phe Ala  Ser Asn Val 
    1070                 1075                 1080             


Val Glu  Lys Cys Val Thr His  Ala Ser Arg Thr Glu  Arg Ala Val 
    1085                 1090                 1095             


Leu Ile  Asp Glu Val Cys Thr  Met Asn Asp Gly Pro  His Ser Ala 
    1100                 1105                 1110             


Leu Tyr  Thr Met Met Lys Asp  Gln Tyr Ala Asn Tyr  Val Val Gln 
    1115                 1120                 1125             


Lys Met  Ile Asp Val Ala Glu  Pro Gly Gln Arg Lys  Ile Val Met 
    1130                 1135                 1140             


His Lys  Ile Arg Pro His Ile  Ala Thr Leu Arg Lys  Tyr Thr Tyr 
    1145                 1150                 1155             


Gly Lys  His Ile Leu Ala Lys  Leu Glu Lys Tyr Tyr  Met Lys Asn 
    1160                 1165                 1170             


Gly Val  Asp Leu Gly Pro Ile  Cys Gly Pro Pro Asn  Gly Ile Ile 
    1175                 1180                 1185             


<210>  47
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Val Ala Cys Val Leu Lys Arg Lys Ala Val Leu Trp Gln Asp 
1               5                   10                  15      


Ser Phe Ser Pro His Leu Lys His His Pro Gln Glu Pro Ala Asn Pro 
            20                  25                  30          


Asn Met Pro Val Val Leu Thr Ser Gly Thr Gly Ser Gln Ala Gln Pro 
        35                  40                  45              


Gln Pro Ala Ala Asn Gln Ala Leu Ala Ala Gly Thr His Ser Ser Pro 
    50                  55                  60                  


Val Pro Gly Ser Ile Gly Val Ala Gly Arg Ser Gln Asp Asp Ala Met 
65                  70                  75                  80  


Val Asp Tyr Phe Phe Gln Arg Gln His Gly Glu Gln Leu Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Tyr Asn Asn Ser Lys His Arg Trp Pro Thr 
            100                 105                 110         


Gly Asp Asn Ile His Ala Glu His Gln Val Arg Ser Met Asp Glu Leu 
        115                 120                 125             


Asn His Asp Phe Gln Ala Leu Ala Leu Glu Gly Arg Ala Met Gly Glu 
    130                 135                 140                 


Gln Leu Leu Pro Gly Lys Lys Phe Trp Glu Thr Asp Glu Ser Ser Lys 
145                 150                 155                 160 


Asp Gly Pro Lys Gly Ile Phe Leu Gly Asp Gln Trp Arg Asp Ser Ala 
                165                 170                 175     


Trp Gly Thr Ser Asp His Ser Val Ser Gln Pro Ile Met Val Gln Arg 
            180                 185                 190         


Arg Pro Gly Gln Ser Phe His Val Asn Ser Glu Val Asn Ser Val Leu 
        195                 200                 205             


Ser Pro Arg Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu Tyr 
    210                 215                 220                 


Val Leu Ser Ser Ser Pro Gly Asp Ser Cys Leu Arg Lys Gly Gly Phe 
225                 230                 235                 240 


Gly Pro Arg Asp Ala Asp Ser Asp Glu Asn Asp Lys Gly Glu Lys Lys 
                245                 250                 255     


Asn Lys Gly Thr Phe Asp Gly Asp Lys Leu Gly Asp Leu Lys Glu Glu 
            260                 265                 270         


Gly Asp Val Met Asp Lys Thr Asn Gly Leu Pro Val Gln Asn Gly Ile 
        275                 280                 285             


Asp Ala Asp Val Lys Asp Phe Ser Arg Thr Pro Gly Asn Cys Gln Asn 
    290                 295                 300                 


Ser Ala Asn Glu Val Asp Leu Leu Gly Pro Asn Gln Asn Gly Ser Glu 
305                 310                 315                 320 


Gly Leu Ala Gln Leu Thr Ser Thr Asn Gly Ala Lys Pro Val Glu Asp 
                325                 330                 335     


Phe Ser Asn Met Glu Ser Gln Ser Val Pro Leu Asp Pro Met Glu His 
            340                 345                 350         


Val Gly Met Glu Pro Leu Gln Phe Asp Tyr Ser Gly Thr Gln Val Pro 
        355                 360                 365             


Val Asp Ser Ala Ala Ala Thr Val Gly Leu Phe Asp Tyr Asn Ser Gln 
    370                 375                 380                 


Gln Gln Leu Phe Gln Arg Pro Asn Ala Leu Ala Val Gln Gln Leu Thr 
385                 390                 395                 400 


Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala Ala His Gln Pro His 
                405                 410                 415     


Ile Gly Leu Ala Pro Ala Ala Phe Val Pro Asn Pro Tyr Ile Ile Ser 
            420                 425                 430         


Ala Ala Pro Pro Gly Thr Asp Pro Tyr Thr Ala Gly Leu Ala Ala Ala 
        435                 440                 445             


Ala Thr Leu Gly Pro Ala Val Val Pro His Gln Tyr Tyr Gly Val Thr 
    450                 455                 460                 


Pro Trp Gly Val Tyr Pro Ala Ser Leu Phe Gln Gln Gln Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Thr Asn Ser Ala Asn Gln Gln Thr Thr Pro Gln Ala 
                485                 490                 495     


Gln Gln Gly Gln Gln Gln Val Leu Arg Gly Gly Ala Ser Gln Arg Pro 
            500                 505                 510         


Leu Thr Pro Asn Gln Asn Gln Gln Gly Gln Gln Thr Asp Pro Leu Val 
        515                 520                 525             


Ala Ala Ala Ala Val Asn Ser Ala Leu Ala Phe Gly Gln Gly Leu Ala 
    530                 535                 540                 


Ala Gly Met Pro Gly Tyr Pro Val Leu Ala Pro Ala Ala Tyr Tyr Asp 
545                 550                 555                 560 


Gln Thr Gly Ala Leu Val Val Asn Ala Gly Ala Arg Asn Gly Leu Gly 
                565                 570                 575     


Ala Pro Val Arg Leu Val Ala Pro Ala Pro Val Ile Ile Ser Ser Ser 
            580                 585                 590         


Ala Ala Gln Ala Ala Val Ala Ala Ala Ala Ala Ser Ala Asn Gly Ala 
        595                 600                 605             


Ala Gly Gly Leu Ala Gly Thr Thr Asn Gly Pro Phe Arg Pro Leu Gly 
    610                 615                 620                 


Thr Gln Gln Pro Gln Pro Gln Pro Gln Gln Gln Pro Asn Asn Asn Leu 
625                 630                 635                 640 


Ala Ser Ser Ser Phe Tyr Gly Asn Asn Ser Leu Asn Ser Asn Ser Gln 
                645                 650                 655     


Ser Ser Ser Leu Phe Ser Gln Gly Ser Ala Gln Pro Ala Asn Thr Ser 
            660                 665                 670         


Leu Gly Phe Gly Ser Ser Ser Ser Leu Gly Ala Thr Leu Gly Ser Ala 
        675                 680                 685             


Leu Gly Gly Phe Gly Thr Ala Val Ala Asn Ser Asn Thr Gly Ser Gly 
    690                 695                 700                 


Ser Arg Arg Asp Ser Leu Thr Gly Ser Ser Asp Leu Tyr Lys Arg Thr 
705                 710                 715                 720 


Ser Ser Ser Leu Thr Pro Ile Gly His Ser Phe Tyr Asn Gly Leu Ser 
                725                 730                 735     


Phe Ser Ser Ser Pro Gly Pro Val Gly Met Pro Leu Pro Ser Gln Gly 
            740                 745                 750         


Pro Gly His Ser Gln Thr Pro Pro Pro Ser Leu Ser Ser His Gly Ser 
        755                 760                 765             


Ser Ser Ser Leu Asn Leu Gly Gly Leu Thr Asn Gly Ser Gly Arg Tyr 
    770                 775                 780                 


Ile Ser Ala Ala Pro Gly Ala Glu Ala Lys Tyr Arg Ser Ala Ser Ser 
785                 790                 795                 800 


Ala Ser Ser Leu Phe Ser Pro Ser Ser Thr Leu Phe Ser Ser Ser Arg 
                805                 810                 815     


Leu Arg Tyr Gly Met Ser Asp Val Met Pro Ser Gly Arg Ser Arg Leu 
            820                 825                 830         


Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu 
        835                 840                 845             


Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg 
    850                 855                 860                 


Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
865                 870                 875                 880 


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
                885                 890                 895     


Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu 
            900                 905                 910         


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
        915                 920                 925             


Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe 
    930                 935                 940                 


Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His 
945                 950                 955                 960 


Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys 
                965                 970                 975     


Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala 
            980                 985                 990         


Phe Lys Gly Gln Val Phe Ala Leu  Ser Thr His Pro Tyr  Gly Cys Arg 
        995                 1000                 1005             


Val Ile  Gln Arg Ile Leu Glu  His Cys Leu Pro Asp  Gln Thr Leu 
    1010                 1015                 1020             


Pro Ile  Leu Glu Glu Leu His  Gln His Thr Glu Gln  Leu Val Gln 
    1025                 1030                 1035             


Asp Gln  Tyr Gly Asn Tyr Val  Ile Gln His Val Leu  Glu His Gly 
    1040                 1045                 1050             


Arg Pro  Glu Asp Lys Ser Lys  Ile Val Ala Glu Ile  Arg Gly Asn 
    1055                 1060                 1065             


Val Leu  Val Leu Ser Gln His  Lys Phe Ala Ser Asn  Val Val Glu 
    1070                 1075                 1080             


Lys Cys  Val Thr His Ala Ser  Arg Thr Glu Arg Ala  Val Leu Ile 
    1085                 1090                 1095             


Asp Glu  Val Cys Thr Met Asn  Asp Gly Pro His Ser  Ala Leu Tyr 
    1100                 1105                 1110             


Thr Met  Met Lys Asp Gln Tyr  Ala Asn Tyr Val Val  Gln Lys Met 
    1115                 1120                 1125             


Ile Asp  Val Ala Glu Pro Gly  Gln Arg Lys Ile Val  Met His Lys 
    1130                 1135                 1140             


Ile Arg  Pro His Ile Ala Thr  Leu Arg Lys Tyr Thr  Tyr Gly Lys 
    1145                 1150                 1155             


His Ile  Leu Ala Lys Leu Glu  Lys Tyr Tyr Met Lys  Asn Gly Val 
    1160                 1165                 1170             


Asp Leu  Gly Pro Ile Cys Gly  Pro Pro Asn Gly Ile  Ile 
    1175                 1180                 1185     


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PUM1_forward primer

<400>  48
gccagcttgt cttcaatgaa at                                                22


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PUM1_reverse primer

<400>  49
caaagccagc ttctgttcaa g                                                 21


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PUM1 probe

<400>  50
atccaccatg agttggtagg cagc                                              24


<210>  51
<211>  1921
<212>  DNA
<213>  Homo sapiens

<400>  51
ggcggaagtg acattatcaa cgcgcgccag gggttcagtg aggtcgggca ggttcgctgt       60

ggcgggcgcc tgggccgccg gctgtttaac ttcgcttccg ctggcccata gtgatctttg      120

cagtgaccca gcatcactgt ttcttggcgt gtgaagataa cccaaggaat tgaggaagtt      180

gctgagaaga gtgtgctgga gatgctctag gaaaaaattg aatagtgaga cgagttccag      240

cgcaagggtt tctggtttgc caagaagaaa gtgaacatca tggatcagaa caacagcctg      300

ccaccttacg ctcagggctt ggcctcccct cagggtgcca tgactcccgg aatccctatc      360

tttagtccaa tgatgcctta tggcactgga ctgaccccac agcctattca gaacaccaat      420

agtctgtcta ttttggaaga gcaacaaagg cagcagcagc aacaacaaca gcagcagcag      480

cagcagcagc agcaacagca acagcagcag cagcagcagc agcagcagca gcagcagcag      540

cagcagcagc agcagcagca acaggcagtg gcagctgcag ccgttcagca gtcaacgtcc      600

cagcaggcaa cacagggaac ctcaggccag gcaccacagc tcttccactc acagactctc      660

acaactgcac ccttgccggg caccactcca ctgtatccct cccccatgac tcccatgacc      720

cccatcactc ctgccacgcc agcttcggag agttctggga ttgtaccgca gctgcaaaat      780

attgtatcca cagtgaatct tggttgtaaa cttgacctaa agaccattgc acttcgtgcc      840

cgaaacgccg aatataatcc caagcggttt gctgcggtaa tcatgaggat aagagagcca      900

cgaaccacgg cactgatttt cagttctggg aaaatggtgt gcacaggagc caagagtgaa      960

gaacagtcca gactggcagc aagaaaatat gctagagttg tacagaagtt gggttttcca     1020

gctaagttct tggacttcaa gattcagaat atggtgggga gctgtgatgt gaagtttcct     1080

ataaggttag aaggccttgt gctcacccac caacaattta gtagttatga gccagagtta     1140

tttcctggtt taatctacag aatgatcaaa cccagaattg ttctccttat ttttgtttct     1200

ggaaaagttg tattaacagg tgctaaagtc agagcagaaa tttatgaagc atttgaaaac     1260

atctacccta ttctaaaggg attcaggaag acgacgtaat ggctctcatg tacccttgcc     1320

tcccccaccc ccttcttttt ttttttttaa acaaatcagt ttgttttggt acctttaaat     1380

ggtggtgttg tgagaagatg gatgttgagt tgcagggtgt ggcaccaggt gatgcccttc     1440

tgtaagtgcc caccgcggga tgccgggaag gggcattatt tgtgcactga gaacaccgcg     1500

cagcgtgact gtgagttgct cataccgtgc tgctatctgg gcagcgctgc ccatttattt     1560

atatgtagat tttaaacact gctgttgaca agttggtttg agggagaaaa ctttaagtgt     1620

taaagccacc tctataattg attggacttt ttaattttaa tgtttttccc catgaaccac     1680

agtttttata tttctaccag aaaagtaaaa atctttttta aaagtgttgt ttttctaatt     1740

tataactcct aggggttatt tctgtgccag acacattcca cctctccagt attgcaggac     1800

agaatatatg tgttaatgaa aatgaatggc tgtacatatt tttttctttc ttcagagtac     1860

tctgtacaat aaatgcagtt tataaaagtg ttagattgtt gttaaaaaaa aaaaaaaaaa     1920

a                                                                     1921


<210>  52
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Asp Gln Asn Asn Ser Leu Pro Pro Tyr Ala Gln Gly Leu Ala Ser 
1               5                   10                  15      


Pro Gln Gly Ala Met Thr Pro Gly Ile Pro Ile Phe Ser Pro Met Met 
            20                  25                  30          


Pro Tyr Gly Thr Gly Leu Thr Pro Gln Pro Ile Gln Asn Thr Asn Ser 
        35                  40                  45              


Leu Ser Ile Leu Glu Glu Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
                85                  90                  95      


Val Ala Ala Ala Ala Val Gln Gln Ser Thr Ser Gln Gln Ala Thr Gln 
            100                 105                 110         


Gly Thr Ser Gly Gln Ala Pro Gln Leu Phe His Ser Gln Thr Leu Thr 
        115                 120                 125             


Thr Ala Pro Leu Pro Gly Thr Thr Pro Leu Tyr Pro Ser Pro Met Thr 
    130                 135                 140                 


Pro Met Thr Pro Ile Thr Pro Ala Thr Pro Ala Ser Glu Ser Ser Gly 
145                 150                 155                 160 


Ile Val Pro Gln Leu Gln Asn Ile Val Ser Thr Val Asn Leu Gly Cys 
                165                 170                 175     


Lys Leu Asp Leu Lys Thr Ile Ala Leu Arg Ala Arg Asn Ala Glu Tyr 
            180                 185                 190         


Asn Pro Lys Arg Phe Ala Ala Val Ile Met Arg Ile Arg Glu Pro Arg 
        195                 200                 205             


Thr Thr Ala Leu Ile Phe Ser Ser Gly Lys Met Val Cys Thr Gly Ala 
    210                 215                 220                 


Lys Ser Glu Glu Gln Ser Arg Leu Ala Ala Arg Lys Tyr Ala Arg Val 
225                 230                 235                 240 


Val Gln Lys Leu Gly Phe Pro Ala Lys Phe Leu Asp Phe Lys Ile Gln 
                245                 250                 255     


Asn Met Val Gly Ser Cys Asp Val Lys Phe Pro Ile Arg Leu Glu Gly 
            260                 265                 270         


Leu Val Leu Thr His Gln Gln Phe Ser Ser Tyr Glu Pro Glu Leu Phe 
        275                 280                 285             


Pro Gly Leu Ile Tyr Arg Met Ile Lys Pro Arg Ile Val Leu Leu Ile 
    290                 295                 300                 


Phe Val Ser Gly Lys Val Val Leu Thr Gly Ala Lys Val Arg Ala Glu 
305                 310                 315                 320 


Ile Tyr Glu Ala Phe Glu Asn Ile Tyr Pro Ile Leu Lys Gly Phe Arg 
                325                 330                 335     


Lys Thr Thr 
            


<210>  53
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP_forward primer

<400>  53
gccaagaaga aagtgaacat cat                                               23


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP_reverse primer

<400>  54
atagggattc cgggagtcat                                                   20


<210>  55
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP probe

<400>  55
tcagaacaac agcctgccac ctta                                              24


<210>  56
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  56
accgccgaga ccgcgtccgc cccgcgagca cagagcctcg cctttgccga tccgccgccc       60

gtccacaccc gccgccagct caccatggat gatgatatcg ccgcgctcgt cgtcgacaac      120

ggctccggca tgtgcaaggc cggcttcgcg ggcgacgatg ccccccgggc cgtcttcccc      180

tccatcgtgg ggcgccccag gcaccagggc gtgatggtgg gcatgggtca gaaggattcc      240

tatgtgggcg acgaggccca gagcaagaga ggcatcctca ccctgaagta ccccatcgag      300

cacggcatcg tcaccaactg ggacgacatg gagaaaatct ggcaccacac cttctacaat      360

gagctgcgtg tggctcccga ggagcacccc gtgctgctga ccgaggcccc cctgaacccc      420

aaggccaacc gcgagaagat gacccagatc atgtttgaga ccttcaacac cccagccatg      480

tacgttgcta tccaggctgt gctatccctg tacgcctctg gccgtaccac tggcatcgtg      540

atggactccg gtgacggggt cacccacact gtgcccatct acgaggggta tgccctcccc      600

catgccatcc tgcgtctgga cctggctggc cgggacctga ctgactacct catgaagatc      660

ctcaccgagc gcggctacag cttcaccacc acggccgagc gggaaatcgt gcgtgacatt      720

aaggagaagc tgtgctacgt cgccctggac ttcgagcaag agatggccac ggctgcttcc      780

agctcctccc tggagaagag ctacgagctg cctgacggcc aggtcatcac cattggcaat      840

gagcggttcc gctgccctga ggcactcttc cagccttcct tcctgggcat ggagtcctgt      900

ggcatccacg aaactacctt caactccatc atgaagtgtg acgtggacat ccgcaaagac      960

ctgtacgcca acacagtgct gtctggcggc accaccatgt accctggcat tgccgacagg     1020

atgcagaagg agatcactgc cctggcaccc agcacaatga agatcaagat cattgctcct     1080

cctgagcgca agtactccgt gtggatcggc ggctccatcc tggcctcgct gtccaccttc     1140

cagcagatgt ggatcagcaa gcaggagtat gacgagtccg gcccctccat cgtccaccgc     1200

aaatgcttct aggcggacta tgacttagtt gcgttacacc ctttcttgac aaaacctaac     1260

ttgcgcagaa aacaagatga gattggcatg gctttatttg ttttttttgt tttgttttgg     1320

tttttttttt ttttttggct tgactcagga tttaaaaact ggaacggtga aggtgacagc     1380

agtcggttgg agcgagcatc ccccaaagtt cacaatgtgg ccgaggactt tgattgcaca     1440

ttgttgtttt tttaatagtc attccaaata tgagatgcgt tgttacagga agtcccttgc     1500

catcctaaaa gccaccccac ttctctctaa ggagaatggc ccagtcctct cccaagtcca     1560

cacaggggag gtgatagcat tgctttcgtg taaattatgt aatgcaaaat ttttttaatc     1620

ttcgccttaa tactttttta ttttgtttta ttttgaatga tgagccttcg tgccccccct     1680

tccccctttt ttgtccccca acttgagatg tatgaaggct tttggtctcc ctgggagtgg     1740

gtggaggcag ccagggctta cctgtacact gacttgagac cagttgaata aaagtgcaca     1800

ccttaaaaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1852


<210>  57
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB_forward primer

<400>  58
ccaaccgcga gaagatga                                                     18


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB_reverse primer

<400>  59
ccagaggcgt acagggatag                                                   20


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB probe

<400>  60
ccatgtacgt tgctatccag gct                                               23


<210>  61
<211>  1229
<212>  DNA
<213>  Homo sapiens

<400>  61
gtctgacggg cgatggcgca gccaatagac aggagcgcta tccgcggttt ctgattggct       60

actttgttcg cattataaaa ggcacgcgcg ggcgcgaggc ccttctctcg ccaggcgtcc      120

tcgtggaagt gacatcgtct ttaaaccctg cgtggcaatc cctgacgcac cgccgtgatg      180

cccagggaag acagggcgac ctggaagtcc aactacttcc ttaagatcat ccaactattg      240

gatgattatc cgaaatgttt cattgtggga gcagacaatg tgggctccaa gcagatgcag      300

cagatccgca tgtcccttcg cgggaaggct gtggtgctga tgggcaagaa caccatgatg      360

cgcaaggcca tccgagggca cctggaaaac aacccagctc tggagaaact gctgcctcat      420

atccggggga atgtgggctt tgtgttcacc aaggaggacc tcactgagat cagggacatg      480

ttgctggcca ataaggtgcc agctgctgcc cgtgctggtg ccattgcccc atgtgaagtc      540

actgtgccag cccagaacac tggtctcggg cccgagaaga cctccttttt ccaggcttta      600

ggtatcacca ctaaaatctc caggggcacc attgaaatcc tgagtgatgt gcagctgatc      660

aagactggag acaaagtggg agccagcgaa gccacgctgc tgaacatgct caacatctcc      720

cccttctcct ttgggctggt catccagcag gtgttcgaca atggcagcat ctacaaccct      780

gaagtgcttg atatcacaga ggaaactctg cattctcgct tcctggaggg tgtccgcaat      840

gttgccagtg tctgtctgca gattggctac ccaactgttg catcagtacc ccattctatc      900

atcaacgggt acaaacgagt cctggccttg tctgtggaga cggattacac cttcccactt      960

gctgaaaagg tcaaggcctt cttggctgat ccatctgcct ttgtggctgc tgcccctgtg     1020

gctgctgcca ccacagctgc tcctgctgct gctgcagccc cagctaaggt tgaagccaag     1080

gaagagtcgg aggagtcgga cgaggatatg ggatttggtc tctttgacta atcaccaaaa     1140

agcaaccaac ttagccagtt ttatttgcaa aacaaggaaa taaaggctta cttctttaaa     1200

aagtaaaaaa aaaaaaaaaa aaaaaaaaa                                       1229


<210>  62
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys 
1               5                   10                  15      


Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys Cys Phe Ile Val Gly Ala 
            20                  25                  30          


Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg 
        35                  40                  45              


Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala 
    50                  55                  60                  


Ile Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys Leu Leu Pro 
65                  70                  75                  80  


His Ile Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu Asp Leu Thr 
                85                  90                  95      


Glu Ile Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg 
            100                 105                 110         


Ala Gly Ala Ile Ala Pro Cys Glu Val Thr Val Pro Ala Gln Asn Thr 
        115                 120                 125             


Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr 
    130                 135                 140                 


Thr Lys Ile Ser Arg Gly Thr Ile Glu Ile Leu Ser Asp Val Gln Leu 
145                 150                 155                 160 


Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu Asn 
                165                 170                 175     


Met Leu Asn Ile Ser Pro Phe Ser Phe Gly Leu Val Ile Gln Gln Val 
            180                 185                 190         


Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile Thr Glu 
        195                 200                 205             


Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn Val Ala Ser 
    210                 215                 220                 


Val Cys Leu Gln Ile Gly Tyr Pro Thr Val Ala Ser Val Pro His Ser 
225                 230                 235                 240 


Ile Ile Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val Glu Thr Asp 
                245                 250                 255     


Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu Ala Asp Pro 
            260                 265                 270         


Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala 
        275                 280                 285             


Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser 
    290                 295                 300                 


Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp 
305                 310                 315         


<210>  63
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys 
1               5                   10                  15      


Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys Cys Phe Ile Val Gly Ala 
            20                  25                  30          


Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg 
        35                  40                  45              


Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala 
    50                  55                  60                  


Ile Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys Leu Leu Pro 
65                  70                  75                  80  


His Ile Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu Asp Leu Thr 
                85                  90                  95      


Glu Ile Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg 
            100                 105                 110         


Ala Gly Ala Ile Ala Pro Cys Glu Val Thr Val Pro Ala Gln Asn Thr 
        115                 120                 125             


Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr 
    130                 135                 140                 


Thr Lys Ile Ser Arg Gly Thr Ile Glu Ile Leu Ser Asp Val Gln Leu 
145                 150                 155                 160 


Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu Asn 
                165                 170                 175     


Met Leu Asn Ile Ser Pro Phe Ser Phe Gly Leu Val Ile Gln Gln Val 
            180                 185                 190         


Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile Thr Glu 
        195                 200                 205             


Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn Val Ala Ser 
    210                 215                 220                 


Val Cys Leu Gln Ile Gly Tyr Pro Thr Val Ala Ser Val Pro His Ser 
225                 230                 235                 240 


Ile Ile Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val Glu Thr Asp 
                245                 250                 255     


Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu Ala Asp Pro 
            260                 265                 270         


Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala 
        275                 280                 285             


Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser 
    290                 295                 300                 


Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp 
305                 310                 315         


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPLP0_forward primer

<400>  64
taaaccctgc gtggcaat                                                     18


<210>  65
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPLP0_reverse primer

<400>  65
acatttcgga taatcatcca atagttg                                           27


<210>  66
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPLP0 probe

<400>  66
aagtagttgg acttccaggt cgcc                                              24


<210>  67
<211>  2458
<212>  DNA
<213>  Homo sapiens

<400>  67
cagaagaagg cagcgcccaa ggcgcatgcg cagcggtcac tcccgctgta tattaaggcg       60

ccggcgatcg cggcctgagg ctgctcccgg acaagggcaa cgagcgtttc gtttggactt      120

ctcgacttga gtgcccgcct ccttcgccgc cgcctctgca gtcctcagcg cagttatgcc      180

cagttcttcc cgctgtgggg acacgaccac ggaggaatcc ttgcttcagg gactcgggac      240

cctgctggac cccttcctcg ggtttagggg atgtggggac caggagaaag tcaggatccc      300

taagagtctt ccctgcctgg atggatgagt ggcttcttct ccacctagat tctttccaca      360

ggagccagca tacttcctga acatggagag tgttgttcgc cgctgcccat tcttatcccg      420

agtcccccag gcctttctgc agaaagcagg caaatctctg ttgttctatg cccaaaactg      480

ccccaagatg atggaagttg gggccaagcc agcccctcgg gcattgtcca ctgcagcagt      540

acactaccaa cagatcaaag aaacccctcc ggccagtgag aaagacaaaa ctgctaaggc      600

caaggtccaa cagactcctg atggatccca gcagagtcca gatggcacac agcttccgtc      660

tggacacccc ttgcctgcca caagccaggg cactgcaagc aaatgccctt tcctggcagc      720

acagatgaat cagagaggca gcagtgtctt ctgcaaagcc agtcttgagc ttcaggagga      780

tgtgcaggaa atgaatgccg tgaggaaaga ggttgctgaa acctcagcag gccccagtgt      840

ggttagtgtg aaaaccgatg gaggggatcc cagtggactg ctgaagaact tccaggacat      900

catgcaaaag caaagaccag aaagagtgtc tcatcttctt caagataact tgccaaaatc      960

tgtttccact tttcagtatg atcgtttctt tgagaaaaaa attgatgaga aaaagaatga     1020

ccacacctat cgagttttta aaactgtgaa ccggcgagca cacatcttcc ccatggcaga     1080

tgactattca gactccctca tcaccaaaaa gcaagtgtca gtctggtgca gtaatgacta     1140

cctaggaatg agtcgccacc cacgggtgtg tggggcagtt atggacactt tgaaacaaca     1200

tggtgctggg gcaggtggta ctagaaatat ttctggaact agtaaattcc atgtggactt     1260

agagcgggag ctggcagacc tccatgggaa agatgccgca ctcttgtttt cctcgtgctt     1320

tgtggccaat gactcaaccc tcttcaccct ggctaagatg atgccaggct gtgagattta     1380

ctctgattct gggaaccatg cctccatgat ccaagggatt cgaaacagcc gagtgccaaa     1440

gtacatcttc cgccacaatg atgtcagcca cctcagagaa ctgctgcaaa gatctgaccc     1500

ctcagtcccc aagattgtgg catttgaaac tgtccattca atggatgggg cggtgtgccc     1560

actggaagag ctgtgtgatg tggcccatga gtttggagca atcaccttcg tggatgaggt     1620

ccacgcagtg gggctttatg gggctcgagg cggagggatt ggggatcggg atggagtcat     1680

gccaaaaatg gacatcattt ctggaacact tggcaaagcc tttggttgtg ttggagggta     1740

catcgccagc acgagttctc tgattgacac cgtacggtcc tatgctgctg gcttcatctt     1800

caccacctct ctgccaccca tgctgctggc tggagccctg gagtctgtgc ggatcctgaa     1860

gagcgctgag ggacgggtgc ttcgccgcca gcaccagcgc aacgtcaaac tcatgagaca     1920

gatgctaatg gatgccggcc tccctgttgt ccactgcccc agccacatca tccctgtgcg     1980

ggttgcagat gctgctaaaa acacagaagt ctgtgatgaa ctaatgagca gacataacat     2040

ctacgtgcaa gcaatcaatt accctacggt gccccgggga gaagagctcc tacggattgc     2100

ccccacccct caccacacac cccagatgat gaactacttc cttgagaatc tgctagtcac     2160

atggaagcaa gtggggctgg aactgaagcc tcattcctca gctgagtgca acttctgcag     2220

gaggccactg cattttgaag tgatgagtga aagagagaag tcctatttct caggcttgag     2280

caagttggta tctgctcagg cctgagcatg acctcaatta tttcacttaa ccccaggcca     2340

ttatcatatc cagatggtct tcagagttgt ctttatatgt gaattaagtt atattaaatt     2400

ttaatctata gtaaaaacat agtcctggaa ataaattctt gcttaaatgg tgaaaaaa       2458


<210>  68
<211>  2281
<212>  DNA
<213>  Homo sapiens

<400>  68
cagaagaagg cagcgcccaa ggcgcatgcg cagcggtcac tcccgctgta tattaaggcg       60

ccggcgatcg cggcctgagg ctgctcccgg acaagggcaa cgagcgtttc gtttggactt      120

ctcgacttga gtgcccgcct ccttcgccgc cgcctctgca gtcctcagcg cagtctttcc      180

acaggagcca gcatacttcc tgaacatgga gagtgttgtt cgccgctgcc cattcttatc      240

ccgagtcccc caggcctttc tgcagaaagc aggcaaatct ctgttgttct atgcccaaaa      300

ctgccccaag atgatggaag ttggggccaa gccagcccct cgggcattgt ccactgcagc      360

agtacactac caacagatca aagaaacccc tccggccagt gagaaagaca aaactgctaa      420

ggccaaggtc caacagactc ctgatggatc ccagcagagt ccagatggca cacagcttcc      480

gtctggacac cccttgcctg ccacaagcca gggcactgca agcaaatgcc ctttcctggc      540

agcacagatg aatcagagag gcagcagtgt cttctgcaaa gccagtcttg agcttcagga      600

ggatgtgcag gaaatgaatg ccgtgaggaa agaggttgct gaaacctcag caggccccag      660

tgtggttagt gtgaaaaccg atggagggga tcccagtgga ctgctgaaga acttccagga      720

catcatgcaa aagcaaagac cagaaagagt gtctcatctt cttcaagata acttgccaaa      780

atctgtttcc acttttcagt atgatcgttt ctttgagaaa aaaattgatg agaaaaagaa      840

tgaccacacc tatcgagttt ttaaaactgt gaaccggcga gcacacatct tccccatggc      900

agatgactat tcagactccc tcatcaccaa aaagcaagtg tcagtctggt gcagtaatga      960

ctacctagga atgagtcgcc acccacgggt gtgtggggca gttatggaca ctttgaaaca     1020

acatggtgct ggggcaggtg gtactagaaa tatttctgga actagtaaat tccatgtgga     1080

cttagagcgg gagctggcag acctccatgg gaaagatgcc gcactcttgt tttcctcgtg     1140

ctttgtggcc aatgactcaa ccctcttcac cctggctaag atgatgccag gctgtgagat     1200

ttactctgat tctgggaacc atgcctccat gatccaaggg attcgaaaca gccgagtgcc     1260

aaagtacatc ttccgccaca atgatgtcag ccacctcaga gaactgctgc aaagatctga     1320

cccctcagtc cccaagattg tggcatttga aactgtccat tcaatggatg gggcggtgtg     1380

cccactggaa gagctgtgtg atgtggccca tgagtttgga gcaatcacct tcgtggatga     1440

ggtccacgca gtggggcttt atggggctcg aggcggaggg attggggatc gggatggagt     1500

catgccaaaa atggacatca tttctggaac acttggcaaa gcctttggtt gtgttggagg     1560

gtacatcgcc agcacgagtt ctctgattga caccgtacgg tcctatgctg ctggcttcat     1620

cttcaccacc tctctgccac ccatgctgct ggctggagcc ctggagtctg tgcggatcct     1680

gaagagcgct gagggacggg tgcttcgccg ccagcaccag cgcaacgtca aactcatgag     1740

acagatgcta atggatgccg gcctccctgt tgtccactgc cccagccaca tcatccctgt     1800

gcgggttgca gatgctgcta aaaacacaga agtctgtgat gaactaatga gcagacataa     1860

catctacgtg caagcaatca attaccctac ggtgccccgg ggagaagagc tcctacggat     1920

tgcccccacc cctcaccaca caccccagat gatgaactac ttccttgaga atctgctagt     1980

cacatggaag caagtggggc tggaactgaa gcctcattcc tcagctgagt gcaacttctg     2040

caggaggcca ctgcattttg aagtgatgag tgaaagagag aagtcctatt tctcaggctt     2100

gagcaagttg gtatctgctc aggcctgagc atgacctcaa ttatttcact taaccccagg     2160

ccattatcat atccagatgg tcttcagagt tgtctttata tgtgaattaa gttatattaa     2220

attttaatct atagtaaaaa catagtcctg gaaataaatt cttgcttaaa tggtgaaaaa     2280

a                                                                     2281


<210>  69
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
1               5                   10                  15      


Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
            20                  25                  30          


Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
        35                  40                  45              


Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
    50                  55                  60                  


Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
65                  70                  75                  80  


Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                85                  90                  95      


Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
            100                 105                 110         


Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
        115                 120                 125             


Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
    130                 135                 140                 


Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
145                 150                 155                 160 


Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                165                 170                 175     


Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
            180                 185                 190         


Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
        195                 200                 205             


Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
    210                 215                 220                 


Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
225                 230                 235                 240 


Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                245                 250                 255     


Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
            260                 265                 270         


His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
        275                 280                 285             


Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
    290                 295                 300                 


Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
305                 310                 315                 320 


Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                325                 330                 335     


Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
            340                 345                 350         


Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
        355                 360                 365             


Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
    370                 375                 380                 


His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
385                 390                 395                 400 


Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                405                 410                 415     


Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
            420                 425                 430         


Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
        435                 440                 445             


Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
    450                 455                 460                 


Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
465                 470                 475                 480 


Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                485                 490                 495     


Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
            500                 505                 510         


Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
        515                 520                 525             


Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
    530                 535                 540                 


Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
545                 550                 555                 560 


Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                565                 570                 575     


His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
            580                 585                 590         


Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
        595                 600                 605             


Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
    610                 615                 620                 


Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
625                 630                 635                 640 


<210>  70
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
1               5                   10                  15      


Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
            20                  25                  30          


Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
        35                  40                  45              


Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
    50                  55                  60                  


Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
65                  70                  75                  80  


Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                85                  90                  95      


Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
            100                 105                 110         


Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
        115                 120                 125             


Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
    130                 135                 140                 


Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
145                 150                 155                 160 


Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                165                 170                 175     


Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
            180                 185                 190         


Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
        195                 200                 205             


Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
    210                 215                 220                 


Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
225                 230                 235                 240 


Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                245                 250                 255     


Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
            260                 265                 270         


His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
        275                 280                 285             


Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
    290                 295                 300                 


Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
305                 310                 315                 320 


Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                325                 330                 335     


Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
            340                 345                 350         


Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
        355                 360                 365             


Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
    370                 375                 380                 


His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
385                 390                 395                 400 


Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                405                 410                 415     


Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
            420                 425                 430         


Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
        435                 440                 445             


Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
    450                 455                 460                 


Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
465                 470                 475                 480 


Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                485                 490                 495     


Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
            500                 505                 510         


Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
        515                 520                 525             


Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
    530                 535                 540                 


Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
545                 550                 555                 560 


Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                565                 570                 575     


His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
            580                 585                 590         


Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
        595                 600                 605             


Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
    610                 615                 620                 


Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
625                 630                 635                 640 


<210>  71
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALAS-1_forward primer

<400>  71
agccacatca tccctgt                                                      17


<210>  72
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALAS-1_reverse primer

<400>  72
cgtagatgtt atgtctgctc at                                                22


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALAS-1 probe

<400>  73
tttagcagca tctgcaaccc gc                                                22

