                         SEQUENCE LISTING

<110>  MEON Medical Solutions GmbH & CoKG
 
<120>  NOVEL CREATININE DEIMINASE AND USES THEROF

<130>  957-3 PCT

<150>  EP 17 209 848.2
<151>  2017-12-21

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  406
<212>  PRT
<213>  Tissierella creatinini

<400>  1

Met Met Lys Lys Phe Ile Asn Ala Lys Ile Tyr Lys Asn Asn Glu Ala 
1               5                   10                  15      


Thr Glu Ile Leu Val Glu Asp Gly Lys Ile Lys Glu Ile Gly Asn Asn 
            20                  25                  30          


Leu Ala Asp Cys Lys Glu Val Ile Asp Leu Gly Gly Lys Met Val Thr 
        35                  40                  45              


Pro Pro Tyr Val Asp Pro His Leu His Leu Asp Tyr Val Tyr Thr Leu 
    50                  55                  60                  


Ala Glu Leu Gly Lys Thr Gly Ala Gly Ser Gly Thr Leu Phe Glu Ala 
65                  70                  75                  80  


Ile Glu Met Trp Pro Val Phe Lys Lys Thr Leu Thr Val Glu Ser Val 
                85                  90                  95      


Lys Lys Leu Ala Leu Lys Gly Val Met Asp Glu Val Ser Gln Gly Val 
            100                 105                 110         


Gln His Ile Arg Thr His Ile Asp Val Thr Asp Pro Lys Phe Thr Gly 
        115                 120                 125             


Leu Lys Ala Met Leu Glu Met Lys Glu Glu Leu Lys Asp Ile Val Asp 
    130                 135                 140                 


Ile Gln Ile Val Ser Phe Pro Gln Gln Gly Met Tyr Thr Tyr Lys Gly 
145                 150                 155                 160 


Gly Arg Glu Leu Val Glu Glu Ala Leu Lys Met Gly Ala Asp Val Val 
                165                 170                 175     


Gly Gly Ile Pro His Tyr Glu Pro Ala Arg Glu Tyr Gly Glu Met Ser 
            180                 185                 190         


Val Lys Ala Thr Val Glu Leu Ala Met Lys Tyr Asp Lys Leu Ile Asp 
        195                 200                 205             


Val His Cys Asp Glu Thr Asp Asp Pro Gln Ala Arg Phe Ile Glu Leu 
    210                 215                 220                 


Leu Asn Ala Leu Val Tyr Leu Glu Gly Tyr Gly Ala Lys Thr Ser Ala 
225                 230                 235                 240 


Ser His Thr Cys Ser Phe Gly Ser Ala Asp Asp Ser Tyr Ala Tyr Arg 
                245                 250                 255     


Met Ile Asp Leu Phe Lys Lys Ser Lys Ile Asn Phe Ile Ser Asn Pro 
            260                 265                 270         


Thr Glu Asn Ala Tyr Leu Gln Gly Arg His Asp Thr Tyr Pro Lys Arg 
        275                 280                 285             


Arg Gly Leu Thr Arg Val Lys Glu Phe Met Glu His Gly Ile Asn Val 
    290                 295                 300                 


Ala Phe Ala Gln Asp Ser Ile Asn Asp Pro Trp Tyr Pro Met Gly Asn 
305                 310                 315                 320 


Gly Asn Met Met Asn Ile Leu Asp Asn Gly Ile His Leu Ala Gln Ile 
                325                 330                 335     


Met Ser Pro Gln Asp Ile Glu Lys Asp Leu Asp Leu Ile Thr Tyr Asn 
            340                 345                 350         


Gly Ala Arg Cys Leu Asn Ile Gln Asp Lys Tyr Leu Leu Glu Val Gly 
        355                 360                 365             


Lys Asp Ser Asn Phe Ile Val Leu Asn Gly Asp Ser Pro Phe Asp Val 
    370                 375                 380                 


Ile Arg Asn Arg Ala Asn Val Leu Ala Cys Val Arg Lys Gly Glu Phe 
385                 390                 395                 400 


Tyr Leu Ser Lys Asn Gln 
                405     


<210>  2
<211>  1593
<212>  DNA
<213>  Tissierella creatinini

<400>  2
ctggcattag tgttattggc tatagcaaca attttgtcaa taactgataa aaatacatta       60

acaaaagaaa aactgtaagc tattaacaat gctaaatttt taaggagtga ttttatgatg      120

aaaaagttta ttaatgcaaa gatttacaag aacaatgaag caacagaaat tttagtagaa      180

gacggtaaaa tcaaagagat tggtaataac ttagcagact gtaaagaagt aattgatcta      240

ggcggtaaaa tggttactcc accttatgta gatcctcacc tacatttaga ttatgtgtat      300

acattggctg aacttggaaa aactggtgct ggctcaggaa ctctttttga agctattgaa      360

atgtggccag tatttaaaaa gactttaact gtagaaagcg ttaaaaaact tgctcttaag      420

ggggttatgg atgaggtttc ccaaggggta caacatattc gtacacatat agatgtaact      480

gatccaaaat tcacaggtct aaaagctatg ttggaaatga aagaagaatt aaaggacata      540

gttgatatcc aaatagtatc attcccacaa caaggaatgt acacatataa gggtggacgt      600

gaattagtag aagaagcact taagatgggt gcagatgttg ttggaggaat tccgcattat      660

gaaccagcta gagaatatgg tgaaatgtct gttaaagcca cagttgaact tgctatgaaa      720

tatgataagc taatagatgt tcactgtgat gagacagatg atcctcaagc acgttttatt      780

gagctattaa atgcacttgt ttatttggaa ggttatggtg caaaaacttc agctagccat      840

acttgttcat ttggttcagc agatgattct tatgcatata gaatgataga cttattcaaa      900

aagagcaaga taaacttcat ctctaatcca actgaaaatg cgtatctaca aggccgtcat      960

gacacttatc caaagcgtcg tggattgact agagttaaag aatttatgga gcatggtatt     1020

aatgttgcat ttgcacaaga ttcaataaac gatccatggt atccaatggg taacggaaat     1080

atgatgaata tacttgacaa tggaattcat ttagctcaaa taatgtcacc acaagatata     1140

gaaaaagatt tagatttaat tacctacaat ggtgctcgtt gcctaaatat ccaagataaa     1200

tatttattag aagtaggtaa agattcaaac tttatcgttc ttaacggaga cagcccattc     1260

gatgtaataa gaaaccgtgc taatgttctt gcttgtgtta gaaaaggaga attctattta     1320

agcaaaaacc agtagaatat gatgtaaaac ttgatttagg cgtaaaatat taatatttta     1380

aaataaattc caaattaacc ccccggtggt gtaataaact ccatcggggg gttttttgtg     1440

ttccagtaga aaataaaaaa atgatataaa aatttagtag tttgaaaaac ttaaataaag     1500

aaagggcgga tttagaatga gtcaaagaga cgtattatat tcaccagatg caaagtacaa     1560

agataataag ggtaaatatg gaattgattt agg                                  1593


<210>  3
<211>  1594
<212>  DNA
<213>  Tissierella creatinini

<400>  3
ctggcattag tgttattggc tatagcaaca attttgtcaa taactgataa aaatacatta       60

acaaaagaaa aactgtaagc tattaacaat gctaaatttt taaggagtga ttttatgatg      120

aaaaagttta ttaatgcaaa gatttacaag aacaatgaag caacagaaat tttagtagaa      180

gacggtaaaa tcaaagagat tggtaataac ttagcagact gtaaagaagt aattgatcta      240

ggcggtaaaa tggttactcc accttatgta gatcctcacc tacatttaga ttatgtgtat      300

acattggctg aacttggaaa aactggtgct ggctcaggaa ctctttttga agctattgaa      360

atgtggccag tatttaaaaa gactttaact gtagaaagcg ttaaaaaact tgctcttaag      420

ggggttatgg atgaggtttc ccaaggggta caacatattc gtacacatat agatgtaact      480

gatccaaaat tcacaggtct aaaagctatg ttggaaatga aagaagaatt aaaggacata      540

gttgatatcc aaatagtatc attcccacaa caaggaatgt acacatataa gggtggacgt      600

gaattagtag aagaagcact taagatgggt gcagatgttg ttggaggaat tccgcattat      660

gaaccagcta gagaatatgg tgaaatgtct gttaaagcca cagttgaact tgctatgaaa      720

tatgataagc taatagatgt tcactgtgat gagacagatg atcctcaagc acgttttatt      780

gagctattaa atgcacttgt ttatttggaa ggttatggtg caaaaacttc agctagccat      840

acttgttcat ttggttcagc agatgattca tatgcatata gaatgataga cttattcaaa      900

aagagcaaga taaacttcat ctctaatcca actgaaaatg cgtatctaca aggccgtcat      960

gacacttatc caaagcgtcg tggattgact agagttaaag aatttatgga gcatggtatt     1020

aatgttgcat ttgcacaaga ttcaataaac gatccatggt atccaatggg taacggaaat     1080

atgatgaata tacttgacaa tggaattcat ttagctcaaa taatgtcacc acaagatata     1140

gaaaaagatt tagatttaat tacctacaat ggtgctcgtt gcctaaatat ccaagataaa     1200

tatggattag aagtaggtaa agatgcaaac tttatcgttc ttaacggaga cagcccattc     1260

gatgtaataa gaaaccgtgc taatgttctt gcttctgtta gaaaaggaga attcctattt     1320

aagcaaaaac cagtagaata tgatgtaaaa cttgatttag gcgtaaaata ttaatatttt     1380

aaaataaatt ccaaattaac cccccggtgg tgtaataaac tccatcgggg ggttttttgt     1440

gttccagtag aaaataaaaa aatgatataa aaatttagta gtttgaaaaa cttaaataaa     1500

gaaagggcgg atttagaatg agtcaaagag acgtattata ttcaccagat gcaaagtaca     1560

aagataataa gggtaaatat ggaattgatt tagg                                 1594


<210>  4
<211>  419
<212>  PRT
<213>  Tissierella creatinini

<400>  4

Met Met Lys Lys Phe Ile Asn Ala Lys Ile Tyr Lys Asn Asn Glu Ala 
1               5                   10                  15      


Thr Glu Ile Leu Val Glu Asp Gly Lys Ile Lys Glu Ile Gly Asn Asn 
            20                  25                  30          


Leu Ala Asp Cys Lys Glu Val Ile Asp Leu Gly Gly Lys Met Val Thr 
        35                  40                  45              


Pro Pro Tyr Val Asp Pro His Leu His Leu Asp Tyr Val Tyr Thr Leu 
    50                  55                  60                  


Ala Glu Leu Gly Lys Thr Gly Ala Gly Ser Gly Thr Leu Phe Glu Ala 
65                  70                  75                  80  


Ile Glu Met Trp Pro Val Phe Lys Lys Thr Leu Thr Val Glu Ser Val 
                85                  90                  95      


Lys Lys Leu Ala Leu Lys Gly Val Met Asp Glu Val Ser Gln Gly Val 
            100                 105                 110         


Gln His Ile Arg Thr His Ile Asp Val Thr Asp Pro Lys Phe Thr Gly 
        115                 120                 125             


Leu Lys Ala Met Leu Glu Met Lys Glu Glu Leu Lys Asp Ile Val Asp 
    130                 135                 140                 


Ile Gln Ile Val Ser Phe Pro Gln Gln Gly Met Tyr Thr Tyr Lys Gly 
145                 150                 155                 160 


Gly Arg Glu Leu Val Glu Glu Ala Leu Lys Met Gly Ala Asp Val Val 
                165                 170                 175     


Gly Gly Ile Pro His Tyr Glu Pro Ala Arg Glu Tyr Gly Glu Met Ser 
            180                 185                 190         


Val Lys Ala Thr Val Glu Leu Ala Met Lys Tyr Asp Lys Leu Ile Asp 
        195                 200                 205             


Val His Cys Asp Glu Thr Asp Asp Pro Gln Ala Arg Phe Ile Glu Leu 
    210                 215                 220                 


Leu Asn Ala Leu Val Tyr Leu Glu Gly Tyr Gly Ala Lys Thr Ser Ala 
225                 230                 235                 240 


Ser His Thr Cys Ser Phe Gly Ser Ala Asp Asp Ser Tyr Ala Tyr Arg 
                245                 250                 255     


Met Ile Asp Leu Phe Lys Lys Ser Lys Ile Asn Phe Ile Ser Asn Pro 
            260                 265                 270         


Thr Glu Asn Ala Tyr Leu Gln Gly Arg His Asp Thr Tyr Pro Lys Arg 
        275                 280                 285             


Arg Gly Leu Thr Arg Val Lys Glu Phe Met Glu His Gly Ile Asn Val 
    290                 295                 300                 


Ala Phe Ala Gln Asp Ser Ile Asn Asp Pro Trp Tyr Pro Met Gly Asn 
305                 310                 315                 320 


Gly Asn Met Met Asn Ile Leu Asp Asn Gly Ile His Leu Ala Gln Ile 
                325                 330                 335     


Met Ser Pro Gln Asp Ile Glu Lys Asp Leu Asp Leu Ile Thr Tyr Asn 
            340                 345                 350         


Gly Ala Arg Cys Leu Asn Ile Gln Asp Lys Tyr Gly Leu Glu Val Gly 
        355                 360                 365             


Lys Asp Ala Asn Phe Ile Val Leu Asn Gly Asp Ser Pro Phe Asp Val 
    370                 375                 380                 


Ile Arg Asn Arg Ala Asn Val Leu Ala Ser Val Arg Lys Gly Glu Phe 
385                 390                 395                 400 


Leu Phe Lys Gln Lys Pro Val Glu Tyr Asp Val Lys Leu Asp Leu Gly 
                405                 410                 415     


Val Lys Tyr 
            


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  5

Ala Ala Ala Leu Glu 
1               5   


<210>  6
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  6
gcggccgcac tcgag                                                        15


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence comprising thrombin cleavage site

<400>  7

Ser Ser Gly Leu Val Pro Arg Gly Ser His 
1               5                   10  


<210>  8
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence comprising thrombin cleavage site

<400>  8
cacagcagcg gcctggtgcc gcgcggcagc cat                                    33


