                         SEQUENCE LISTING

<110>  Yale University
       Bennett, Anton
       Ellman, Jonathan
       Jamali, Haya
       Anderson, Karen  S
       Lolis, Elias
       Hoyer, Denton
 
<120>  Compounds and Compositions for Treating Fibrosis

<130>  047162-7106WO1(00798)

<150>  US 62/607,110
<151>  2017-12-18

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MOD
<222>  (1)..(1)
<223>  N-terminus derivatived with FITC-AHA 
       [5-(fluorescein-amido)hexylacrylic acid]

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  1

Asp Glu Leu Thr Gly Tyr Val Ala Thr Arg 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminus derivatived with FITC-AHA 
       [5-(fluorescein-amido)hexylacrylic acid]

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  2

Asp Glu Leu Thr Gly Tyr Val Ala Thr Arg 
1               5                   10  


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Nle

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  PHOSPHORYLATION

<400>  3

Asp Asp Glu Xaa Tyr Gly Tyr Val Ala Thr Arg 
1               5                   10      


<210>  4
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Pro Ser Pro Leu Asp Asp Arg Val Val Val Ala Leu Ser Arg 
1               5                   10                  15      


Pro Val Arg Pro Gln Asp Leu Asn Leu Cys Leu Asp Ser Ser Tyr Leu 
            20                  25                  30          


Gly Ser Ala Asn Pro Gly Ser Asn Ser His Pro Pro Val Ile Ala Thr 
        35                  40                  45              


Thr Val Val Ser Leu Lys Ala Ala Asn Leu Thr Tyr Met Pro Ser Ser 
    50                  55                  60                  


Ser Gly Ser Ala Arg Ser Leu Asn Cys Gly Cys Ser Ser Ala Ser Cys 
65                  70                  75                  80  


Cys Thr Val Ala Thr Tyr Asp Lys Asp Asn Gln Ala Gln Thr Gln Ala 
                85                  90                  95      


Ile Ala Ala Gly Thr Thr Thr Thr Ala Ile Gly Thr Ser Thr Thr Cys 
            100                 105                 110         


Pro Ala Asn Gln Met Val Asn Asn Asn Glu Asn Thr Gly Ser Leu Ser 
        115                 120                 125             


Pro Ser Ser Gly Val Gly Ser Pro Val Ser Gly Thr Pro Lys Gln Leu 
    130                 135                 140                 


Ala Ser Ile Lys Ile Ile Tyr Pro Asn Asp Leu Ala Lys Lys Met Thr 
145                 150                 155                 160 


Lys Cys Ser Lys Ser His Leu Pro Ser Gln Gly Pro Val Ile Ile Asp 
                165                 170                 175     


Cys Arg Pro Phe Met Glu Tyr Asn Lys Ser His Ile Gln Gly Ala Val 
            180                 185                 190         


His Ile Asn Cys Ala Asp Lys Ile Ser Arg Arg Arg Leu Gln Gln Gly 
        195                 200                 205             


Lys Ile Thr Val Leu Asp Leu Ile Ser Cys Arg Glu Gly Lys Asp Ser 
    210                 215                 220                 


Phe Lys Arg Ile Phe Ser Lys Glu Ile Ile Val Tyr Asp Glu Asn Thr 
225                 230                 235                 240 


Asn Glu Pro Ser Arg Val Met Pro Ser Gln Pro Leu His Ile Val Leu 
                245                 250                 255     


Glu Ser Leu Lys Arg Glu Gly Lys Glu Pro Leu Val Leu Lys Gly Gly 
            260                 265                 270         


Leu Ser Ser Phe Lys Gln Asn His Glu Asn Leu Cys Asp Asn Ser Leu 
        275                 280                 285             


Gln Leu Gln Glu Cys Arg Glu Val Gly Gly Gly Ala Ser Ala Ala Ser 
    290                 295                 300                 


Ser Leu Leu Pro Gln Pro Ile Pro Thr Thr Pro Asp Ile Glu Asn Ala 
305                 310                 315                 320 


Glu Leu Thr Pro Ile Leu Pro Phe Leu Phe Leu Gly Asn Glu Gln Asp 
                325                 330                 335     


Ala Gln Asp Leu Asp Thr Met Gln Arg Leu Asn Ile Gly Tyr Val Ile 
            340                 345                 350         


Asn Val Thr Thr His Leu Pro Leu Tyr His Tyr Glu Lys Gly Leu Phe 
        355                 360                 365             


Asn Tyr Lys Arg Leu Pro Ala Thr Asp Ser Asn Lys Gln Asn Leu Arg 
    370                 375                 380                 


Gln Tyr Phe Glu Glu Ala Phe Glu Phe Ile Glu Glu Ala His Gln Cys 
385                 390                 395                 400 


Gly Lys Gly Leu Leu Ile His Cys Gln Ala Gly Val Ser Arg Ser Ala 
                405                 410                 415     


Thr Ile Val Ile Ala Tyr Leu Met Lys His Thr Arg Met Thr Met Thr 
            420                 425                 430         


Asp Ala Tyr Lys Phe Val Lys Gly Lys Arg Pro Ile Ile Ser Pro Asn 
        435                 440                 445             


Leu Asn Phe Met Gly Gln Leu Leu Glu Phe Glu Glu Asp Leu Asn Asn 
    450                 455                 460                 


Gly Val Thr Pro Arg Ile Leu Thr Pro Lys Leu Met Gly Val Glu Thr 
465                 470                 475                 480 


Val Val 
        


