                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  REGULATION OF MUTANT TERT BY BRAF V600E/MAP KINASE PATHWAY 
       THROUGH FOS/GABP IN HUMAN CANCER

<130>  P15106-02

<150>  62/609,587
<151>  2017-12-22

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-F

<400>  1
gtccgaggtg tccctgagta                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-R

<400>  2
cagggcctcg tcttctacag                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH-F

<400>  3
tgcaccacca actgcttagc                                                   20


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH-R

<400>  4
ggcatggact gtggtcatga g                                                 21


<210>  5
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPA-F

<400>  5
ggggtaccac tgaccggcca aaggttag                                          28


<210>  6
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPA-R

<400>  6
ccctcgagtc ggaggggagc ttgaacta                                          28


<210>  7
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-F

<400>  7
ggggtacctc cttccgtctc ccaggatt                                          28


<210>  8
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-R

<400>  8
ccctcgagaa tccccaccga aaagtccc                                          28


<210>  9
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-F

<400>  9
cgacgcgtgg ctcccagtgg attcgc                                            26


<210>  10
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-R

<400>  10
ccgctcgagc ctcgcggtag tggctg                                            26


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-T232A-F

<400>  11
ccagaggttg ccgccccgga gtctg                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-T232A-R

<400>  12
cagactccgg ggcggcaacc tctgg                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-T325A-F

<400>  13
gagcccctgt gcgctccggt ggtca                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-T325A-R

<400>  14
tgaccaccgg agcgcacagg ggctc                                             25


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-T331A-F

<400>  15
ggtggtcacc tgtgctccca gctgcac                                           27


<210>  16
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-T331A-R

<400>  16
gtgcagctgg gagcacaggt gaccacc                                           27


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-S374A-F

<400>  17
gactcgctca gcgcacccac gctgc                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FOS-S374A-R

<400>  18
gcagcgtggg tgcgctgagc gagtc                                             25


<210>  19
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BRAF-A1799T-F

<400>  19
attttggtct agctacagtg aaatctcgat ggagtgg                                37


<210>  20
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BRAF-A1799T-R

<400>  20
ccactccatc gagatttcac tgtagctaga ccaaaat                                37


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-C228T-F

<400>  21
ggcccagccc cttccgggcc ctc                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-C228T-R

<400>  22
gagggcccgg aaggggctgg gcc                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-250T-F

<400>  23
ccgtcccgac cccttccggg tcc                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-C250T-R

<400>  24
ggacccggaa ggggtcggga cgg                                               23


<210>  25
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-FOS-binding-mut-F

<400>  25
ggatgctggg agctagactc actcgcaca                                         29


<210>  26
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-FOS-binding-mut-R

<400>  26
tgtgcgagtg agtctagctc ccagcatcc                                         29


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-MUC-binding-mut-F

<400>  27
ctcactcgca cacgatgtgt ccctccg                                           27


<210>  28
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-MYC-binding-mut-R

<400>  28
cggagggaca catcgtgtgc gagtgag                                           27


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-F

<400>  29
ggattcgcgg gcacagac                                                     18


<210>  30
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TERT-R

<400>  30
gggagcgcgc ggcatcg                                                      17


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-F

<400>  31
aaagattccg cactctccgt                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GABPB-R

<400>  32
aatccccacc gaaaagtccc                                                   20


<210>  33
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  33
tacagtgaaa t                                                            11


<210>  34
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  34
tacagagaaa t                                                            11


<210>  35
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  35
cttgactcac tcgcacacca tgtgtc                                            26


<210>  36
<211>  380
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(380)
<223>  Human c-Fos amino acid sequence (Uniprot P01100-1)

<400>  36

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


